CN114590475B - Liquid storage release device - Google Patents
Liquid storage release device Download PDFInfo
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- CN114590475B CN114590475B CN202011429848.8A CN202011429848A CN114590475B CN 114590475 B CN114590475 B CN 114590475B CN 202011429848 A CN202011429848 A CN 202011429848A CN 114590475 B CN114590475 B CN 114590475B
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- RVTZCBVAJQQJTK-UHFFFAOYSA-N oxygen(2-);zirconium(4+) Chemical compound [O-2].[O-2].[Zr+4] RVTZCBVAJQQJTK-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D25/00—Details of other kinds or types of rigid or semi-rigid containers
- B65D25/38—Devices for discharging contents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
- B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
- B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
- B65D81/18—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents providing specific environment for contents, e.g. temperature above or below ambient
Abstract
The embodiment of the disclosure provides a liquid storage release device, which belongs to the field of biochips. The liquid storage release device provided by the embodiment of the disclosure comprises a liquid storage cavity and a fever reducing structure. The liquid storage cavity is provided with a liquid outlet, the liquid outlet can be blocked by a blocking structure, and the blocking structure is made of a thermosensitive material and can be heated and melted; the heating structure is arranged opposite to the liquid outlet, and the heating structure can enable the plugging structure to be melted during operation so as to release liquid in the liquid storage cavity. Because the plugging structure adopts thermosensitive material to make, when consequently needing to release liquid, heating structure work makes the plugging structure melt to liquid in the stock solution cavity can flow from the leakage fluid dram, with the sample contact with react, the stock solution release device that this disclosed embodiment provided can save liquid and automatic release liquid, and simple structure, the operation is safe.
Description
Technical Field
The invention belongs to the technical field of biochips, and particularly relates to a liquid storage and release device.
Background
At present, most biological reactions in biological detection chips require the participation of a liquid, and the liquid can provide a stable and dynamic reaction environment for biological molecules. In most biological reactions, the liquid as the reaction reagent is contacted with the sample before detection, so that a liquid storage and release device is needed to realize automatic release of the reaction reagent.
In the prior art, the device for realizing the liquid storage release has a complex structure or has the problems of potential safety hazard and the like, and is difficult to realize application.
Disclosure of Invention
The embodiment of the disclosure aims to at least solve one of the technical problems in the prior art, and provides a liquid storage release device which can automatically release liquid and has a simple and safe structure.
The technical scheme that solves this disclosure embodiment technical problem adoption is a stock solution release, includes:
the liquid storage cavity is provided with a liquid outlet, the liquid outlet can be blocked by a blocking structure, and the blocking structure is made of a heat-sensitive material and can be heated and melted;
the heating structure is arranged opposite to the liquid outlet, and the heating structure can enable the plugging structure to be melted when working so as to release liquid in the liquid storage cavity.
According to the liquid storage release device, liquid is prestored in the liquid storage cavity, the liquid outlet of the liquid storage cavity is sealed by the plugging structure to store the liquid, and the plugging structure is made of a heat-sensitive material, so that the plugging structure is heated and melted when the heating structure works, the liquid in the liquid storage cavity can flow out of the liquid outlet and is contacted with a sample to react.
In some examples, further comprising: the plugging structure is arranged at the liquid outlet so as to plug the liquid outlet, and is made of a heat-sensitive material and can be heated and melted.
In some examples, the heating structure includes: the substrate is sequentially arranged on the electrode layer, the heat release layer and the insulating layer on one side of the substrate, which is close to the liquid storage cavity; the electrode layer comprises a first electrode and a second electrode, the first electrode and the second electrode are both connected with the heat release layer, and the first electrode and the second electrode are respectively connected with the anode and the cathode of an external power supply so as to form a current loop to enable the heat release layer to release heat to melt the plugging structure;
the heating structure further includes a first opening penetrating the substrate, the insulating layer, and the heat release layer; the orthographic projection of the liquid drain on the substrate is at least partially overlapped with the first opening, and the orthographic projections of the first electrode and the second electrode on the substrate are not overlapped with the first opening.
In some examples, the heating structure is detachably connected to the drain port of the liquid storage chamber through a first opening thereof.
In some examples, further comprising: the flow guiding structure is arranged at one side of the heating structure, which is away from the liquid storage cavity; at least one first slot and at least one second slot which are communicated are arranged on one side, close to the heating structure, of the flow guiding structure, and the width of the second slot is smaller than that of the first slot;
each of the at least one first slot extends to an edge of the flow guiding structure, and an orthographic projection of the liquid drain port on the flow guiding structure at least partially overlaps with the at least one first slot.
In some examples, the flow directing structure includes a plurality of spaced apart defining portions, any two adjacent defining portions defining one of the first slot or the second slot.
In some examples, the flow directing structure has a circular slot; the limiting parts are sector limiting parts, and the central angles corresponding to the sector limiting parts are the same; the plurality of sector limiting parts are arranged in the circular groove, the circle center corresponding to each sector limiting part coincides with the circle center of the circular groove, and the radius of each sector limiting part is smaller than the radius of the circular groove.
In some examples, the reservoir chamber includes a main chamber, a drain channel, and a connecting channel in communication, the connecting channel connected between the main chamber and the drain channel; the opening of the liquid discharge channel, which is away from the main chamber, is used as the liquid discharge port; wherein,
the main chamber and the liquid discharge channel are cylindrical, and the caliber of the liquid discharge channel is smaller than that of the main chamber; the caliber of the connecting channel gradually decreases from the main chamber to the direction of the liquid discharge channel.
In some examples, the connecting channel is a rounded connecting channel.
In some examples, the liquid storage chamber comprises a main chamber and a cover plate, the liquid drain is arranged at one end of the main chamber, and the cover plate covers the other end of the main chamber; the cover plate is provided with an exhaust port;
the reservoir release device further includes a waterproof membrane covering the vent for preventing external moisture from entering the main chamber and preventing liquid in the main chamber from volatilizing.
Drawings
FIG. 1 is a schematic diagram of an embodiment of a reservoir delivery device provided in accordance with an embodiment of the present disclosure;
FIG. 2 is a schematic diagram of one embodiment of a reservoir chamber of a reservoir release device provided in accordance with embodiments of the present disclosure;
FIG. 3 is a schematic view (front view) of one embodiment of a reservoir chamber of a reservoir release device provided in an embodiment of the present disclosure;
FIG. 4 is a schematic diagram of one embodiment of a heating structure of a reservoir releasing apparatus provided in an embodiment of the present disclosure;
FIG. 5 is a schematic structural view of an embodiment of a diversion structure of a liquid storage and release device according to an embodiment of the present disclosure;
fig. 6 is a schematic structural view of another embodiment of a diversion structure of a liquid storage and release device according to an embodiment of the disclosure;
fig. 7 is a schematic diagram illustrating a positional relationship of an embodiment of a diversion structure of a liquid storage and release device according to an embodiment of the disclosure;
FIG. 8 is a schematic view of another embodiment of a reservoir delivery device provided in accordance with an embodiment of the present disclosure;
fig. 9 is a schematic structural view (connection state) of another embodiment of a liquid storage release device according to an embodiment of the present disclosure.
Detailed Description
The present invention will be described in further detail below with reference to the drawings and detailed description for the purpose of better understanding of the technical solution of the present invention to those skilled in the art.
The shapes and sizes of the various components in the drawings are not to scale, but are merely intended to facilitate an understanding of the contents of the embodiments of the present invention.
Unless defined otherwise, technical or scientific terms used in this disclosure should be given the ordinary meaning as understood by one of ordinary skill in the art to which this disclosure belongs. The terms "first," "second," and the like, as used in this disclosure, do not denote any order, quantity, or importance, but rather are used to distinguish one element from another. Likewise, the terms "a," "an," or "the" and similar terms do not denote a limitation of quantity, but rather denote the presence of at least one. The word "comprising" or "comprises", and the like, means that elements or items preceding the word are included in the element or item listed after the word and equivalents thereof, but does not exclude other elements or items. The terms "connected" or "connected," and the like, are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "upper", "lower", "left", "right", etc. are used merely to indicate relative positional relationships, which may also be changed when the absolute position of the object to be described is changed.
As shown in fig. 1-4, embodiments of the present disclosure provide a reservoir release device that includes a reservoir chamber 1 and a heating structure 2.
Specifically, the liquid storage chamber 1 is used for storing a liquid, which may be a liquid reagent commonly used in chemistry or medicine, such as pure water, a buffer solution, a detection solution, and the like, without limitation. The liquid storage cavity 1 is provided with a liquid outlet 1a, and the liquid outlet 1a can be blocked by a blocking structure 4, so that liquid is sealed and stored. The plugging structure 4 may be made of a heat sensitive material, so that the plugging structure 4 can be melted by heat. The heating structure 2 is arranged opposite to the liquid outlet 1a of the liquid storage chamber 1, that is, the heating structure 2 is arranged close to the liquid outlet 1a of the liquid storage chamber 1, and the heating structure 2 can enable the plugging structure 4 to be melted in operation, so that when the liquid in the liquid storage chamber 1 needs to be released, the heating structure 2 works to enable the plugging structure 4 to be heated and melted, and then the liquid in the liquid storage chamber 1 can be released, and the liquid is discharged from the liquid outlet 1a to be contacted with a sample for reaction. In the liquid storage release device provided by the embodiment of the disclosure, the liquid (for example, a reagent) to be stored can be introduced into the liquid storage chamber 1 through the liquid outlet 1a, a certain volume of liquid is stored in the liquid storage chamber 1 in advance and is sealed by the plugging structure 4 to realize long-term storage, and when detection is needed, the heating structure 2 is only required to work so as to enable the plugging structure 4 to be melted, and the liquid can be released to react with a sample, so that a fresh sample can be collected, and the liquid storage release device has a simple structure and is safe to operate.
In some examples, the liquid storage chamber 1 may be made of various shapes of housing, or a cavity may be made in a single piece of material, and the cavity forms the liquid storage space of the liquid storage chamber 1. The material of the liquid storage chamber 1 may include various materials, such as polymethyl methacrylate (Plymethyl Methacrylate, PMMA), polycarbonate (PC), and the like, without limitation.
In some examples, the drain port 1a may be disposed at any position of the liquid storage chamber 1, for example, at a side of the liquid storage chamber 1 adjacent to the heating structure 2 in the extending direction, and may be other positions. The liquid discharge port 1a is provided below the liquid storage chamber 1. The shape of the liquid discharge port 1a may include a circle, a square, a triangle, etc., without limitation. The size of the liquid discharge port 1a may be various, for example, if the liquid discharge port 1a is a circular liquid discharge port, the caliber of the liquid discharge port 1a may be between [1,3] mm, and is not limited herein.
In some examples, referring to fig. 2 and 3, the plugging structure 4 may be part of a liquid storage release device provided in the embodiments of the present disclosure, and is preset at the liquid outlet 1a of the liquid storage chamber 1, or various heat-sensitive materials may be selected as the plugging structure 4 to seal the liquid outlet 1a of the liquid storage chamber 1, and if the plugging structure 4 is part of the liquid storage release device, the plugging structure 4 is arranged at the liquid outlet 1a of the liquid storage chamber 1, and specifically, the plugging structure 4 covers the liquid outlet 1a to plug the liquid outlet 1a. The shape of the blocking structure 4 may be set according to the shape of the liquid outlet 1a, so that the blocking structure 4 can be inserted into the liquid outlet 1a to block the liquid outlet 1a. The plugging structure 4 is made of a heat sensitive material which is capable of melting after being heated. The heat-sensitive material forming the plugging structure 4 is solid in the environment of normal temperature (for example, below 45 ℃) and can be melted into liquid after being heated to a certain temperature (for example, above 45 ℃), and the heat-sensitive material does not react with the liquid stored in the liquid storage chamber 1, so that the influence on the purity of the liquid after the plugging structure 4 is melted can be avoided. Also, in some embodiments, the density of the heat sensitive material forming the plugging structure 4 may be less than the density of the liquid stored in the liquid storage chamber 1, so that the plugging structure 4 melted into a liquid state can float up to the side of the liquid storage chamber 1 facing away from the liquid drain port 1a due to the low density. The heat-sensitive material forming the plugging structure 4 may include various materials, for example, paraffin is solid in the normal temperature environment, the liquid outlet 1a of the plugging column is plugged, if the liquid needs to be released, the heating structure 2 heats, the paraffin is melted into liquid, because the density of the paraffin is lower, the melted paraffin floats up to one side of the liquid storage chamber 1, which is away from the liquid outlet 1a, due to the effect of the density, and the liquid storage chamber 1 is away from the heating structure 2, so that the temperature is lower, the melted paraffin floats up and then is condensed into solid, the paraffin does not react with the liquid, so that the liquid in the liquid storage chamber 1 is discharged from the liquid outlet 1a, the paraffin condensed into solid is retained in the liquid storage chamber 1, and the paraffin cannot flow out of the liquid outlet 1a, so that the paraffin is prevented from blocking the liquid outlet 1a, and the paraffin can be prevented from polluting the liquid. Of course, the plugging structure 4 may be made of other heat sensitive materials, which is not limited herein.
In some examples, referring to fig. 1 and 4, in the liquid storage release device provided in the embodiment of the present disclosure, the heating structure 2 may include a substrate 21, and an electrode layer 22, a heat release layer 23, and an insulating layer 24 sequentially disposed on a side of the substrate 21 near the liquid storage chamber 1, the electrode layer 22 may be disposed on a side of the substrate 1 near the liquid storage chamber 1, the electrode layer 22 may include a first electrode 221 and a second electrode 222, the first electrode 221 is connected to the heat release layer 23, the second electrode 222 is also connected to the heat release layer 23, one of the first electrode 221 and the second electrode 222 is connected to a positive electrode of an external power source, and the other is connected to a negative electrode of the external power source, so that the first electrode 221, the heat release layer 23, the second electrode 222, and the external power source form a current loop, and current is applied to the heat release layer 23 releases heat (joule heat) to melt the blocking structure 4 to release liquid.
And, with continued reference to fig. 1 and 4, in order to enable the liquid to flow out, the heating structure 2 may further include a first opening 2a, where the first opening 2a penetrates through the substrate 21, the insulating layer 22 and the heat release layer 23, and an orthographic projection of the first electrode 221 in the electrode layer 22 on the substrate 21 does not overlap with the first opening 2a, and an orthographic projection of the second electrode 222 in the electrode layer 22 on the substrate 21 also does not overlap with the first opening 2 a. The first opening 2a is disposed opposite to the liquid outlet 1a of the liquid storage chamber 1, that is, the orthographic projection of the liquid outlet 1a on the substrate 21 is at least partially overlapped with the first opening 2a, so that the liquid can flow out from the liquid outlet 1a to the first opening 2a, and then the solution flowing into the holding sample from the first opening 2a reacts with the sample.
In some examples, with continued reference to fig. 1 and 4, the heat release layer 23 may be selected to have a thermoelectric effect, i.e., a material capable of converting a substantial portion of electrical energy into thermal energy, e.g., the material of the heat release layer 23 may include at least one of indium tin oxide, nichrome, iron-chromium-aluminum alloy, barium titanate ceramic, silicon carbide, lanthanum chromate, zirconium oxide, and molybdenum disilicide, each of which converts electrical energy into thermal energy upon conduction, releasing a substantial amount of heat to melt the plugging structure 4. The material of the heat release layer 23 is exemplified by indium tin oxide, but the present invention is not limited thereto.
In some examples, with continued reference to fig. 1 and 4, in the liquid release device provided in the embodiments of the present disclosure, since the plugging structure 4 melted into a liquid state floats up to the upper portion of the liquid storage chamber 1 to be condensed into a solid, the heat release layer 23 can control the amount of heat released by the plugging structure 4 while releasing heat, so that the released heat only melts the plugging structure 4, but the temperature of the liquid on the side of the liquid storage chamber 1 facing away from the liquid drain port 1a is not too high, so that the material of the plugging structure 4 cannot be condensed into a solid. In some examples, the heat release layer 23 may be provided in a coverage area according to the required heat, for example, referring to fig. 4, the heat release layer 23 is ring-shaped and provided around only the periphery of the first opening 2a, not to cover the entire substrate 1. Specifically, the orthographic projection of the heat release layer 23 on the substrate 1 surrounds the first opening 2a, does not overlap with the first opening 2a, and overlaps with the orthographic projections of the first electrode 221 and the second electrode 222 on the substrate 1, but does not completely cover the first electrode 221 and the second electrode 222, so that the heat released by the heat release layer 23 only affects the blocking structure 4 at the liquid outlet 1a above the first opening 2a, and the temperature of the liquid on the side of the liquid storage chamber 1 facing away from the liquid outlet 1a is not excessively high.
In some examples, the first electrode 221 and the second electrode 222 of the electrode layer 22 may be strip-shaped electrodes respectively disposed at two sides of the first opening 2a and overlapped with the pattern of the heat release layer 23, and of course, the first electrode 221 and the second electrode 22 may also be electrodes of other shapes, which are not limited herein.
In some examples, an insulating layer 24 is provided on the side of the electrode layer 22 adjacent to the reservoir chamber 1, the insulating layer 24 being capable of protecting the patterned structure of the heat-emitting layer 23 and the electrode layer 22. The material of the insulating layer 24 may include various materials, such as silicon oxide (e.g., silicon dioxide) or silicon nitride (e.g., silicon nitride), but may be other insulating materials, which are not limited herein.
In some examples, the insulating layer 24 may have a first via hole (not shown) and a second via hole (not shown) therein, and the heating structure 2 may further include a first connection line (not shown) and a second connection line (not shown) therein, one end of the first connection line being connected to the first electrode 221 through the first via hole, the other end of the first connection line being connected to an anode (or a cathode) of an external power source, and similarly, one end of the second connection line being connected to the second electrode 222 through the second via hole, the other end of the second connection line being connected to a cathode (or an anode) of an external voltage. Of course, the first electrode 221 and the second electrode 222 may be connected to an external power source in other manners, which is not limited herein.
In some examples, the substrate 21 may include various types of substrates, such as a glass substrate, a quartz substrate, and the like, as long as a metal or non-metal material can be made on the substrate 21 by a sputtering process or the like, which is not limited herein.
In some examples, as shown in fig. 1, the first opening 2a of the heating structure 2 and the liquid outlet 1a of the liquid storage chamber 1 may be coaxially disposed and fixedly connected, for example, by bonding with optical adhesive (OCA adhesive). Or, the heating structure 2 may be detachably connected to the liquid outlet 1a of the liquid storage chamber 1 at the first opening 2a, for example, a clamping seat is disposed in a peripheral area of the first opening 2a, a buckle adapted to the clamping seat is disposed in a peripheral area of the liquid outlet 1a, and the heating structure 2 is detachably connected to the liquid storage chamber 1 through the detachment of the clamping seat and the buckle.
In some examples, referring to fig. 2 and 3, the liquid storage chamber 1 may include a main chamber 11, a liquid discharge channel 13 and a connection channel 12 which are communicated, the connection channel 12 is connected between the main chamber 11 and the liquid discharge channel 13, specifically, a second end opening of the main chamber 11 is close to a first end opening of the connection channel 12 compared to a first end opening of the main chamber 11, and the second end opening of the main chamber 11 is tightly connected with the first end opening of the connection channel 12, so that a caliber of the second end opening of the main chamber 11 is the same as a caliber of the first end opening of the connection channel 12; the first end opening of the liquid discharge channel 13 is close to the second end opening of the connecting channel 12 compared with the second end opening of the liquid discharge channel 13, and the first end opening of the liquid discharge channel 13 is tightly connected with the second end opening of the connecting channel 12, so that the caliber of the first end opening of the liquid discharge channel 13 is the same as that of the second end opening of the connecting channel 12; the second end opening of the drain passage 13 (i.e., the opening facing away from the main chamber 11) serves as the drain port 1a. Wherein, the main chamber 11 and the liquid discharge channel 13 are both cylindrical cavities, the caliber of the liquid discharge channel 13 is smaller than that of the main chamber 11, the connecting channel 12 is used as a transition channel between the liquid discharge channel 13 and the main chamber 11, the caliber of the connecting channel 12 gradually decreases from the caliber of the main chamber 11 to the caliber of the liquid discharge channel 13, and the extending direction of the wall surface of the connecting channel 12 and the extending direction of the wall surface of the main chamber 11 have a certain angle, so that liquid can be discharged from the liquid discharge port 1a along the inclined wall surface of the connecting channel 12, thereby reducing the residual of liquid.
In some examples, referring to fig. 2 and 3, the connection channel 12 is a rounded connection channel, that is, the connection channel 12 is prevented from being an arc surface, and the bending direction is away from the inside of the cavity of the liquid storage chamber 1, so that the main chamber 11 can be smoothly transited to the liquid discharge channel 13, and because the connection channel 12 is a rounded connection channel, the cavity of the liquid storage chamber 1 formed by connecting the main chamber 11, the connection channel 12 and the liquid discharge channel 13 is not easy to remain at the corner of the liquid, so that the main chamber 11 can be smoothly transited to the liquid discharge channel 13, thereby reducing the liquid remaining in the cavity of the liquid storage chamber 1 and reducing the waste of the liquid.
In some examples, referring to fig. 2 and 3, the liquid storage chamber 1 includes a main chamber 11 and a cover plate 14, specifically, the liquid storage chamber 1 may include the main chamber 11, a liquid discharge channel 13, a connection channel 12, and the cover plate 14 that are in communication, the liquid discharge port 1a is disposed at one end of the main chamber 11 (specifically, may be disposed at an end of the liquid discharge channel 13 facing away from the main chamber 11), while the other end of the main chamber 11 is open, and the cover plate 14 covers the other end of the main chamber 11. When liquid needs to be stored, the liquid outlet 1a can be sealed by the plugging structure 4, then the cover plate 14 is opened, the liquid is led into the main chamber 11, and then the cover plate 14 is covered to seal the main chamber 11. Further, the cover plate 14 may be provided with the air outlet 1b, and the liquid storage release device may further include a waterproof film 5, the waterproof film 5 covering the air outlet, the waterproof film 5 being capable of preventing external moisture from entering the main chamber 11, and preventing liquid in the main chamber 11 from volatilizing, and being capable of balancing the air pressure inside and outside the main chamber 11. Specifically, the waterproof membrane 5 may be disposed on the side of the cover plate 14 facing away from the main chamber 11, so as to facilitate disassembly; it may be provided on the side of the cover plate 15 close to the main chamber 11 to reduce the probability of the waterproofing membrane 5 falling off.
Alternatively, the waterproof membrane 5 may be made of various types of materials, such as polytetrafluoroethylene, but may be other materials, without limitation.
Alternatively, the main chamber 11 and the cover 14 may be integrally formed, so that the liquid to be stored may be injected from the vent 1b, and the waterproof film 5 may be provided on the vent 1b, which is not limited herein.
In some examples, referring to fig. 5-8, the liquid storage release device provided in the embodiments of the present disclosure further includes a flow guiding structure 3, where the flow guiding structure 3 is disposed on a side of the heating structure 2 facing away from the liquid storage chamber 1, and the flow guiding structure 3 is used to guide the released liquid into a container containing a sample. The side of the flow guiding structure 3 near the heating structure 2 is provided with at least one first slot 31 and at least one second slot 32 which are communicated, each first slot 31 in the at least one first slot 31 extends to the edge of the flow guiding structure 3, the orthographic projection of the liquid outlet 1a of the liquid storage structure 1 on the flow guiding structure 3 is at least partially overlapped with the at least one first slot 31, the orthographic projection of the first opening 2a of the heating structure 2 on the flow guiding structure 3 is also at least partially overlapped with the at least one first slot 31, so that after the liquid is released, the liquid flows from the liquid outlet 1a to the first opening 2a, flows into the first slot 31 from the edge of the flow guiding structure 3 along the extending direction of the first slot 31, and flows into a container containing a sample. The width of the second slot 32 is smaller than that of the first slot 31, so that the liquid flows onto the flow guiding structure 3, and the first slot 31 forms a capillary flow channel to have capillary action. When the liquid needs to be released, the heating structure 2 heats to enable the plugging structure 4 to be melted into a liquid state, and most of the material of the plugging structure 4 in the liquid state can rise to the upper part of the liquid storage cavity 1 due to the floating force and is condensed into a solid state due to the temperature reduction in the rising process, and stays in the liquid storage cavity 1. However, there may be a small portion of the material of the plugging structure 4 in a liquid state adhered to the liquid outlet 1a and flushed into the first slot 31 of the flow guiding structure 3 by the first opening 2a along with the released liquid, so as to cause slot blocking, but since the flow guiding structure 3 is further provided with the second slot 32, the second slot 32 is communicated with the first slot 31, the second slot 32 is a capillary flow channel, the material of the plugging structure 4 in a liquid state flowing into the first slot 31 can be preferentially sucked into the second slot 32 with a narrower state due to capillary action, and the number of the second slots 32 can be set according to the volume of the material of the plugging structure 4 flowing into the flow guiding structure 3, so that the material of the plugging structure 4 can be prevented from blocking the first slot 31, and the liquid cannot flow out.
In some examples, the width of the first slot 31 is [1,2] millimeters, the depth of the first slot 31 is [1,2] millimeters, and/or the width of the second slot 32 is [0.1, 1) millimeters, and the depth of the second slot 31 is [0.1, 1) millimeters. Of course, the width and depth of the first slot 31 and the width and depth of the second slot 32 may be other values, and may specifically be set according to the volume and type of the liquid, and the volume and type of the material of the plugging structure 4 are not limited herein.
In some examples, the number of the first slots 31 may be one or more, and if the number of the first slots 31 is one, the container containing the sample may be disposed at the end of the first slots 31 extending to the edge of the flow guiding structure 3; if the number of the first grooves 32 is plural, the caliber of the container containing the sample may be larger than the size of the entire flow guiding structure 3, and be disposed below the flow guiding structure 3, so that the liquid flowing out of the plural first grooves 32 can flow into the container. The number of second grooves 32 may also be one or more, and may be specifically set according to the volume of the material flowing into the blocking structure 4 of the flow guiding structure 3. In fig. 5, the air guiding structure 3 is provided with a first slot 31 and two second slots 32 as an example.
In some examples, the shapes of the first slot 31 and the second slot 32 may not be limited, for example, the first slot 31 and/or the second slot 32 may be rectangular, circular, annular, etc., and the first slot 31 and the second slot 32 may be an integral slot or may be defined by a plurality of defining portions. For example, referring to fig. 6, the flow guiding structure 3 may include a plurality of defining portions 031 arranged at intervals, and any two adjacent defining portions 031 define one first slot 31 or second slot 32.
In some examples, the defining portions 031 may be of various shapes, such as rectangular, circular, fan-shaped, etc., with continued reference to fig. 6, the flow guiding structure 3 has one circular slot 032, and the defining portions 031 are fan-shaped defining portions, and the central angles corresponding to each fan-shaped defining portion are the same, that is, the arc lengths of the arc edges of the defining portions 031 are also the same. A plurality of sector-shaped limiting parts (namely limiting parts 031) are arranged in the circular slot 032, the corresponding circle center of each sector-shaped limiting part coincides with the circle center of the circular slot 032, the radius of each sector-shaped limiting part is smaller than that of the circular slot, and the edges of two adjacent sector-shaped limiting parts define a first slot 31 or a second slot 32.
Specifically, referring to fig. 7, in order to show the positional relationship between the circular groove 032 and the fan-shaped defining portion 031, fig. 7 shows only a diagram in which one of the fan-shaped defining portions 031 is disposed in the circular groove 032, and other defining portions 031 are disposed in the same manner as the defining portion 031. The fan-shaped limiting part 031 comprises a short arc side 031a, a long arc side 031b and two sides 031c extending along the radial direction, the first ends of the two sides 031c are respectively connected to two sides of the short arc side 031a, the second ends of the two sides 031c are respectively connected to two sides of the long arc side 031b, the corresponding circle center of the fan-shaped limiting part 031 is coincident with the circle center of the circular slot 032 (as shown by the circle center 0 in fig. 7), therefore, the extending direction of the sides of the fan-shaped limiting part 031 (i.e. the extending direction of the radius R1 of the fan-shaped limiting part) is coincident with the extending direction of the radius R2 of the circular slot 032, the length of the radius R1 of the fan-shaped limiting part 031 is smaller than the radius R2 of the circular slot 032, and therefore the long arc side 031b of the fan-shaped limiting part 031 is close to the circular edge of the circular slot 032, the circle center of the fan-shaped limiting part 031b is a certain distance from the circle edge of the circular slot 032, and the fan-shaped limiting part 031b is arranged along the first circle center of the circular slot 031b, the plurality of the fan-shaped limiting parts 031 are adjacent to the first circle slot 031b and the circular slot 031 is defined between the first circle slot and the circular slot 031, and the second circle slot 031 is defined between the circle slot-shaped side 031 is defined by the circle center of the circle slot-shaped side 031. One end of the second slot 32 is communicated with the round hole slot 313, the other end of the second slot 32 is communicated with the annular slot 312, and the extending direction of the second slot 32 is the radial direction of the round slot 032, namely, a plurality of second slots 32 are radially arranged in the round slot 032 along each radius of the round slot 032, the linear type slot 311, the annular slot 312 and the round hole slot 313 form a first slot 31, one end of the linear type slot 311 extends to the edge of the flow guiding structure 3, the other end of the linear type slot 311 is communicated with the annular slot 312 through the annular slot 312, and then extends to the round hole slot 313 to be communicated with the round hole slot 313. In this embodiment, referring to fig. 8 and 9, the orthographic projection of the liquid outlet 1a of the liquid storage structure 1 on the guiding structure 3 at least partially overlaps with the round hole sub-slot 313, the orthographic projection of the first opening 2a of the heating structure 2 on the guiding structure also at least partially overlaps with the round hole sub-slot 313, and in some examples, the round hole sub-slot 313, the liquid outlet 1a and the first opening 2a may be coaxially disposed. Thus, referring to fig. 9, the liquid outlet 1a of the liquid storage structure 1 is connected with the first opening 2a of the heating structure 2, the first opening 2a of the heating structure 2 is connected with the round hole slot 313 of the first slot 31 of the flow guiding structure 3, when the liquid needs to be released, the heat release layer 23 of the heating structure 3 conducts electricity and releases heat, so that the blocking structure 4 at the liquid outlet 1a is melted into a liquid state, and the liquid in the liquid storage chamber 1 flows into the round hole slot 313 from the liquid outlet 1a through the first opening 2a and flows out of the flow guiding structure 3 through the linear type slot 311. The material of the plugging structure 4 in a liquid state floats up above the liquid storage chamber 1 to be condensed into solid, and remains in the liquid storage chamber 1, and a small part of the material possibly rushes into the round hole sub-slot 313 along with the liquid from the liquid outlet 1a and the first opening 2a, and the periphery of the round hole sub-slot 313 is provided with the communicated second slot 32, so that the material of the plugging structure 4 in a liquid state can be preferentially sucked into the second slot 32 under the capillary action, and the plurality of radially arranged second slots 32 can absorb the material of the plugging structure 4 in all liquid states to the maximum extent, so that the liquid is not influenced to flow into the linear sub-slot 311 from the round hole sub-slot 313 of the first slot 31 and then flow out, thereby preventing the plugging structure 4 from blocking the first slot 31, and improving the reliability of the liquid releasing device provided by the embodiments of the disclosure.
Of course, the number, shape and arrangement of the first slots 31 and the second slots 32 of the flow guiding structure 3 may be other manners, which are not limited herein.
It is to be understood that the above embodiments are merely illustrative of the application of the principles of the present invention, but not in limitation thereof. Various modifications and improvements may be made by those skilled in the art without departing from the spirit and substance of the invention, and are also considered to be within the scope of the invention.
Claims (10)
1. A reservoir delivery device, comprising:
the liquid storage cavity is provided with a liquid outlet, the liquid outlet can be blocked by a blocking structure, and the blocking structure is made of a heat-sensitive material and can be heated and melted;
the heating structure is arranged opposite to the liquid outlet, and can enable the plugging structure to be melted when in operation so as to release liquid in the liquid storage cavity;
the flow guiding structure is arranged at one side of the heating structure, which is away from the liquid storage cavity; at least one first slot and at least one second slot which are communicated are arranged on one side, close to the heating structure, of the flow guiding structure, and the width of the second slot is smaller than that of the first slot; and the orthographic projection of the liquid outlet on the flow guiding structure is at least partially overlapped with the at least one first slot.
2. The reservoir delivery device of claim 1, further comprising: the plugging structure is arranged at the liquid outlet so as to plug the liquid outlet, and is made of a heat-sensitive material and can be heated and melted.
3. The reservoir delivery device of claim 1, wherein the heating structure comprises: the substrate is sequentially arranged on the electrode layer, the heat release layer and the insulating layer on one side of the substrate, which is close to the liquid storage cavity; the electrode layer comprises a first electrode and a second electrode, the first electrode and the second electrode are both connected with the heat release layer, and the first electrode and the second electrode are respectively connected with the anode and the cathode of an external power supply so as to form a current loop to enable the heat release layer to release heat to melt the plugging structure; the heating structure further includes a first opening penetrating the substrate, the insulating layer, and the heat release layer; the orthographic projection of the liquid drain on the substrate is at least partially overlapped with the first opening, and the orthographic projections of the first electrode and the second electrode on the substrate are not overlapped with the first opening.
4. A reservoir release device as defined in claim 3, wherein the heating structure is detachably connected to the drain port of the reservoir chamber through the first opening thereof.
5. The fluid reservoir delivery apparatus of any of claims 1-4, wherein each of the at least one first slot extends to an edge of the flow directing structure.
6. The fluid reservoir delivery apparatus of claim 5, wherein the flow directing structure comprises a plurality of spaced apart defining portions, any two adjacent defining portions defining one of the first slot or the second slot.
7. The fluid reservoir delivery device of claim 6, wherein the flow directing structure has a circular slot; the limiting parts are sector limiting parts, and the central angles corresponding to the sector limiting parts are the same; the plurality of sector limiting parts are arranged in the circular groove, the circle center corresponding to each sector limiting part coincides with the circle center of the circular groove, and the radius of each sector limiting part is smaller than the radius of the circular groove.
8. The liquid storage release device according to claim 1, wherein the liquid storage chamber includes a main chamber, a liquid discharge passage, and a connection passage that are communicated, the connection passage being connected between the main chamber and the liquid discharge passage; the opening of the liquid discharge channel, which is away from the main chamber, is used as the liquid discharge port; wherein,
the main chamber and the liquid discharge channel are cylindrical, and the caliber of the liquid discharge channel is smaller than that of the main chamber; the caliber of the connecting channel gradually decreases from the main chamber to the direction of the liquid discharge channel.
9. The reservoir delivery device of claim 8, wherein the connecting channel is a rounded connecting channel.
10. The liquid storage release device according to claim 1, wherein the liquid storage chamber includes a main chamber and a cover plate, the liquid discharge port is provided at one end of the main chamber, and the cover plate covers the other end of the main chamber; the cover plate is provided with an exhaust port;
the reservoir release device further includes a waterproof membrane covering the vent for preventing external moisture from entering the main chamber and preventing liquid in the main chamber from volatilizing.
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