CN114586741A

CN114586741A - Application of GlcN in shortening of dam labor

Info

Publication number: CN114586741A
Application number: CN202210500806.1A
Authority: CN
Inventors: 冯涛; 刘彦; 肖霖力; 白佳桦; 宋玉清; 秦玉圣; 许晓玲; 孙立晨
Original assignee: Beijing Academy of Agriculture and Forestry Sciences; Beijing University of Agriculture
Current assignee: Beijing Academy of Agriculture and Forestry Sciences; Beijing University of Agriculture
Priority date: 2022-05-10
Filing date: 2022-05-10
Publication date: 2022-06-07

Abstract

The invention provides the use of GlcN for shortening the labor of dam. Specifically, glucosamine is added into feed every day in the last month of pregnant female animals and fed at a ratio of 18-30 g/head/day. The invention provides a new application of glucosamine, which is used for shortening the delivery process of female animals, shortening the delivery time of the animals, reducing the dead fetus probability formed by the death of the animals due to easy asphyxia in the delivery process and reducing the death of the fetus.

Description

Application of GlcN in shortening of dam labor

Technical Field

The invention belongs to the technical field, and particularly relates to application of GlcN in shortening the labor of female animals.

Background

The modern industrialized pig raising has extremely high production efficiency, the number of born sows is 12-16, the body consumption is large, the number of born sows is frequent, the recovery interval is short, and the physiological pressure of the sows is extremely high. If during production, long labor can lead to debilitation, easy dystocia and dystocia during delivery, the injury degree of the birth canal of the sow is aggravated, the labor can be excessively consumed due to the long labor, acidosis can occur, the intrauterine distress and even dystocia of the fetus can be caused, and the risk of cesarean section yield and production is greatly increased. How to effectively shorten the labor course is a technical problem which needs to be solved urgently.

Glucosamine (GlcN), molecular formula C₆H₁₃NO₅The natural glucosamine has the effects of repairing articular cartilage, promoting secretion of joint fluid, promoting generation of joint synovial fluid, effectively reducing friction of joint surfaces, relieving joint pain and swelling, recovering joint gaps and the like. Can stimulate the growth of chondrocytes, improve joint movement and relieve joint pain. It has good therapeutic effect on rheumatic arthritis, is a main raw material for synthesizing antibiotic and anticancer medicine, and can be used in food, cosmetics and feed additive.

Most of the time of modern sow production is in the positioning fence, which limits the activities of sows and affects physique. In addition, the batch-type timing insemination process of the sow can expect to obtain more litter size by promoting follicular development, so that the stress degree of the sow in the later stage of pregnancy is increased. These all have a negative effect on the labor of the sow during parturition, and at present, no effective relief method is disclosed.

Disclosure of Invention

In order to solve the technical problems, the invention provides a new application of glucosamine, and particularly, glucosamine is adopted to shorten the labor course of dams.

In order to achieve the purpose, the invention adopts the following technical scheme that:

a method for shortening the labor of female animals with glucosamine comprises adding glucosamine into feed during the last month of gestation of female animals, and continuously feeding until parturition.

As mentioned above, the dam is preferably an animal such as a sow, monkey, ewe, cow, etc.

In the method as described above, the female animals are preferably sows, and the amount of glucosamine fed to the sows is 18-30 g/head per day from 85 days of gestation to the day of delivery.

In the method described above, the daily supplementary feed amount is preferably 24 g/head of glucosamine.

Use of glucosamine for shortening the labor of a dam.

As mentioned above, it is preferable that glucosamine is added to the feed at a daily ratio of 18-30 g/head/day in the last month of gestational mother animal.

Preferably, the dam is a sow, and the glucosamine is supplemented to the sow at a rate of 18-30 g/head of glucosamine per day in the last month of pregnancy.

For use as described above, preferably, the last month is the beginning of day 85 of gestation in the sow.

For use as described above, preferably the amount of supplementary feeding glucosamine is 24 g/day/head.

Application of glucosamine in preparation of preparation for shortening dam production process is provided.

The invention has the beneficial effects that:

the application of the glucosamine in shortening the labor of the dam animals provided by the invention provides a new application of the glucosamine in shortening the labor of the dam animals, and the glucosamine is mainly added into feed for feeding the pregnant dam animals at 18-30 g/head/day in the last month, so that the labor time of the animals can be effectively shortened, the oxidative stress level of the pre-parturient dam animals is improved, the probability of dead fetus caused by the fact that the animals are easy to suffocate and die in the process of delivery because of staying in the birth canal is reduced, and the death rate of the fetus is reduced.

Detailed Description

The following examples are intended to further illustrate the invention but should not be construed as limiting it. Modifications and substitutions may be made thereto without departing from the spirit and scope of the invention.

Unless otherwise specified, the technical means used in the examples are conventional means well known to those skilled in the art, and unless otherwise specified, the reagents used in the present invention are analytically pure or above.

Example 1

1. Test animals and additives

The sow is a Dan-series growing binary sow, and the number of births is 3-4. Glucosamine (GlcN) selected for the test of this example was a food grade material with a purity of 99% and purchased from Zhengzhou Kangyuan chemical products Co., Ltd.

2. Sow grouping and handling

The production process of the pig farm is batch production, 1 batch is selected according to the production flow to carry out the test, the sows in the batch are randomly divided into 4 treatment groups according to the columns of the breeding house, each group of pigs is treated by 1, and the 4 treatments are respectively as follows: the control group (no GlcN added), the GlcN group at 18 g/head/day, the GlcN group at 24 g/head/day and the GlcN group at 30 g/head/day, the addition time being the last month of pregnancy (85 days of pregnancy to delivery), GlcN was added in a hopper by using a measuring cup, and simultaneously with the feed, the feed was put into a trough for feeding the sows, and the sows were fed with pellet feed for 566 pregnant sows.

3. Data collection

Transferring the sows into a gestation house in 112 days of gestation, recording the litter size and the number of dead births of the sows during delivery, and calculating the dead births rate; and the labor was recorded as the time from the start of delivery to the last expulsion of the placenta of the sow compared to the control group and the results are shown in table 1. And calculating the stillbirth rate by counting the farrowing condition of the sow, wherein the stillbirth rate is compared with the stillbirth rate by percentage compared with a control group, and the result is shown in a table 2.

And blood was collected through the auricular vein before parturition, serum was separated, the content of Malondialdehyde (MDA) and superoxide dismutase (SOD) in serum was measured using ELISA kit (shanghai hengyuan), and total antioxidant capacity (T-AOC) was measured biochemically, with the results shown in table 3.

4. Statistical analysis

Analyzing the influence of different additive treatments on the birth process of the sow by using one-way variance, wherein the data are expressed by mean +/-standard deviation, and the P value is less than 0.05 to indicate that the obvious difference exists,

TABLE 1 Effect of GlcN addition at the end of gestation on sow labor

TABLE 2 influence of GlcN addition at end of gestation on sow farrowing

Table 3 influence of GlcN addition on sow antenatal blood antioxidant index at the end of pregnancy

Note: different lower case letters in the same column indicate significant differences (P < 0.05).

From the test results, the delivery process of the sows can be shortened by adding GlcN feeding to the last month of the pregnant sows, wherein the delivery process can be shortened by 21.6 minutes and 38.4 minutes (P < 0.05) by 18 g/head/day and 30 g/head/day respectively by GlcN feeding, and the delivery process can be shortened by 49.8 minutes (P < 0.05) by 24 g/head/day; the simultaneous GlcN addition can reduce the dead-tire rate, wherein the addition of 18 g/head/day and 30 g/head/day can reduce the dead-tire rate by 2.32% and 2.07%, respectively (P > 0.05), and the addition of 24 g/head/day can reduce the dead-tire rate by 2.67% (P < 0.05). The situation of the pregnant sows that the oxygen stress is applied to the pregnant sows in the near birth process is obviously improved by adding GlcN feeding in the later period of pregnancy, wherein the 24 g/head/day GlcN addition can obviously reduce the MDA level and obviously increase the T-AOC and SOD levels (P is less than 0.05), and the 18 g/head/day and 30 g/head/day GlcN can relieve the oxygen stress to a certain extent, but the effect is not as good as that of the 24 g/head/day addition. The experimental results show that the glucosamine can obviously shorten the labor process, shorten the interval of piglet delivery, improve the oxidative stress level of the antenatal sow and reduce the stillbirth rate of the piglet caused by asphyxia death in the birth channel of the sow due to detention in the process of delivery.

Claims

1. A method for reducing the labor of female animals with glucosamine comprises adding glucosamine to the feed for the last month of the animal female animals, and continuously feeding until parturition.

2. The method of claim 1, wherein the dam is a sow, monkey, ewe, cow.

3. The method as claimed in claim 1, wherein the female animal is a sow and the amount of glucosamine fed daily is 18-30 g/head from day 85 of gestation to day of delivery of the sow.

4. The method of claim 3, wherein the daily supplementary feed amount is 24 g/head glucosamine.

5. Use of glucosamine for shortening the labor of a dam.

6. The use of claim 5, wherein the glucosamine is fed to the female animals in the last month of pregnancy by adding glucosamine to the feed at a dose of 18-30 g/head/day per day.

7. The use as claimed in claim 5, wherein the dam is a sow and the glucosamine is supplemented to the sow at 18-30 g/head per day during the last month of gestation.

8. The use of claim 7 wherein said last month is the beginning of day 85 of sow pregnancy.

9. Use according to claim 7, wherein the amount of supplementary glucosamine is 24 g/day/head.

10. Application of glucosamine in preparation of preparation for shortening dam production process is provided.