CN114558068A - 一种祛头屑治顽癣瘙痒的膏剂制备技术 - Google Patents
一种祛头屑治顽癣瘙痒的膏剂制备技术 Download PDFInfo
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- CN114558068A CN114558068A CN202210257309.3A CN202210257309A CN114558068A CN 114558068 A CN114558068 A CN 114558068A CN 202210257309 A CN202210257309 A CN 202210257309A CN 114558068 A CN114558068 A CN 114558068A
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Abstract
本发明提供一种祛头屑治顽癣瘙痒的膏剂制备技术，涉及祛头屑洗发用品技术领域。该祛头屑治顽癣瘙痒的膏剂，按重量份计，其由如下原材料组成：苦参90‑110份、地肤子10‑30份、蛇床子10‑30份、花椒5‑15份、土槿皮20‑40份、白鲜皮10‑30份、硫磺40‑60份、酮康唑5‑15份、医用煤焦油5‑15份、甲基纤维素3‑8份、海藻酸钠0.5‑1.5份、麦芽糊精3‑8份、尼泊尔金0.5‑1.5份、香精1‑3份、色素0.5‑1.5份、去离子水70‑90份，所述膏剂呈液体膏状。本发明提供一种祛头屑治顽癣瘙痒的膏剂制备技术，该膏剂使用的原料容易采购、制作方法简单、成本低、容易掌握，并且去屑效率更高，去屑起效时间更早，止痒效果更加显著，能够直接进行使用，或者用作生产化妆品日化类祛除头屑的洗发类产品的原料进行使用，使用非常舒适。
Description
技术领域
本发明涉及祛头屑洗发用品技术领域，具体为一种祛头屑治顽癣瘙痒的膏剂制备技术。
背景技术
随着生活节奏的加快，生活压力的增加以及环境污染问题的日趋严重，使得现代人的脱发、头发枯黄等头发疾病的发病率越来越高，在我国成人人群中有3亿多典型的脱发患者、白发早衰患者，脱发和白发都是病理现象，需要尽早治疗，同时脱发人群数量以每年15％左右的速度增长，而且脱发人群正趋向年轻化，脱发不仅严重影响人们正常的工作和生活，还严重摧残患者的心理健康，给工作、生活和社交活动等造成大小不等的影响。
头屑是指头皮角质层细胞以白色或灰色鳞屑形式的异常脱落，这种脱落的鳞屑即为头皮屑，头屑产生的原因通常分为生理性和病理性，生理性头屑是我们皮肤、头皮、表皮细胞不停地新陈代谢产生的，头皮光滑，通常看不到明显的脱屑。病理性脱屑则是头皮上皮细胞过度增生，引起的临床上一系列的疾病，头皮屑出现时，常常伴有头皮炎症和头皮瘙痒等症状，如果不采取恰当的方法针对性的治疗，该病可能会周期性、复发性或持续性的发生，严重时可导致头皮毛囊损伤，形成永久性脱发。
为了消除头屑，市面上有一些去屑剂产品，常见的有去油脂产品、抗菌产品和细胞生长抑制剂，这些去屑剂在使用初期效果明显，但停用或长期使用后头屑容易再生，常常表现出耐药性，究其原因是化学去屑仅停留在表面清洁，不能彻底根除头屑，反而使化学成分残留在头皮上，造成头皮受到进一步的刺激和伤害。
发明内容
（一）解决的技术问题
针对现有技术的不足，本发明提供了一种祛头屑治顽癣瘙痒的膏剂制备技术，解决了市面上常见的去屑剂在使用初期效果明显，但停用或长期使用后头屑容易再生，常常表现出耐药性，究其原因是化学去屑仅停留在表面清洁，不能彻底根除头屑，反而使化学成分残留在头皮上，造成头皮受到进一步的刺激和伤害的问题。
（二）技术方案
为实现以上目的，本发明通过以下技术方案予以实现：一种祛头屑治顽癣瘙痒的膏剂，按重量份计，其由如下原材料组成：苦参90-110份、地肤子10-30份、蛇床子10-30份、花椒5-15份、土槿皮20-40份、白鲜皮10-30份、硫磺40-60份、酮康唑5-15份、医用煤焦油5-15份、甲基纤维素3-8份、海藻酸钠0.5-1.5份、麦芽糊精3-8份、尼泊尔金0.5-1.5份、香精1-3份、色素0.5-1.5份、去离子水70-90份，所述膏剂呈液体膏状。
优选的，按重量份计，其由如下原材料组成：苦参90份、地肤子10份、蛇床子10份、花椒5份、土槿皮20份、白鲜皮10份、硫磺40份、酮康唑5份、医用煤焦油5份、甲基纤维素3份、海藻酸钠0.5份、麦芽糊精3份、尼泊尔金0.5份、香精1份、色素0.5份、去离子水70份，所述膏剂呈液体膏状。
优选的，按重量份计，其由如下原材料组成：苦参100份、地肤子20份、蛇床子20份、花椒10份、土槿皮30份、白鲜皮20份、硫磺50份、酮康唑10份、医用煤焦油10份、甲基纤维素5份、海藻酸钠1份、麦芽糊精5份、尼泊尔金1份、香精2份、色素1份、去离子水80份，所述膏剂呈液体膏状。
优选的，按重量份计，其由如下原材料组成：苦参95份、地肤子15份、蛇床子15份、花椒8份、土槿皮25份、白鲜皮15份、硫磺45份、酮康唑9份、医用煤焦油11份、甲基纤维素6份、海藻酸钠0.8份、麦芽糊精6份、尼泊尔金0.8份、香精1.5份、色素0.7份、去离子水85份，所述膏剂呈液体膏状。
优选的，按重量份计，其由如下原材料组成：苦参110份、地肤子30份、蛇床子30份、花椒15份、土槿皮40份、白鲜皮30份、硫磺60份、酮康唑15份、医用煤焦油15份、甲基纤维素8份、海藻酸钠1.5份、麦芽糊精8份、尼泊尔金1.5份、香精3份、色素1.5份、去离子水90份，所述膏剂呈液体膏状。
优选的，所述香精为玫瑰香精、桃花香精、茉莉香精、苹果香精、薰衣草香精中的一种或多种。
优选的，所述色素的颜色为蓝色、红色、黄色或粉色。
优选的，该祛头屑治顽癣瘙痒的膏剂制备方法，其特征在于，包括以下步骤：
S1.先将白鲜皮、地肤子、蛇床子、花椒、硫磺粉碎过100目筛；
S2.再将苦参、土槿皮加水煎煮两次，并合并煎液，浓缩至稠膏状；
S3.再加入酮康唑、医用煤焦油、甲基纤维素、海藻酸钠、麦芽糊精、尼泊尔金以及上述的粉碎物并混合均匀，即得到该祛头屑治顽癣瘙痒的膏剂；
S4.最后对制备的膏剂进行称重、定量内外包装即可。
（三）有益效果
本发明提供了一种祛头屑治顽癣瘙痒的膏剂制备技术。具备以下有益效果：
1、本发明提供了一种祛头屑治顽癣瘙痒的膏剂制备技术，该膏剂使用的原料容易采购、制作方法简单、成本低、容易掌握，并且去屑效率更高，去屑起效时间更早，止痒效果更加显著，使用非常舒适。
2、本发明提供了一种祛头屑治顽癣瘙痒的膏剂制备技术，该膏剂具有杀菌、消炎作用，能够有效促进头部血液循环，抑制细菌在头皮表面滋生，有效消除头皮炎症，并且能够维持头皮细胞的柔软和湿润，促进头皮新陈代谢，具有良好的抗炎、舒缓肌肤的作用，兼具一定的控油效果，可减少头皮分泌过多皮脂，抑制细菌的繁殖，从而可持续改善脱发、去头皮屑、去头油等症状，具有气味芬芳，湿洗后头发顺滑不毛躁的特点。
3、本发明提供了一种祛头屑治顽癣瘙痒的膏剂制备技术，能够直接进行使用，或者用作生产化妆品日化类祛除头屑的洗发类产品的原料进行使用，使用非常方便。
具体实施方式
下面将对本发明实施例中的技术方案进行清楚、完整地描述，显然，所描述的实施例仅仅是本发明一部分实施例，而不是全部的实施例。基于本发明中的实施例，本领域普通技术人员在没有做出创造性劳动前提下所获得的所有其他实施例，都属于本发明保护的范围。
实施例1：
本发明实施例提供一种祛头屑治顽癣瘙痒的膏剂，按重量份计，其由如下原材料组成：苦参90份、地肤子10份、蛇床子10份、花椒5份、土槿皮20份、白鲜皮10份、硫磺40份、酮康唑5份、医用煤焦油5份、甲基纤维素3份、海藻酸钠0.5份、麦芽糊精3份、尼泊尔金0.5份、香精1份、色素0.5份、去离子水70份，所述膏剂呈液体膏状。
该祛头屑治顽癣瘙痒的膏剂制备方法，包括以下步骤：
S1.先将白鲜皮、地肤子、蛇床子、花椒、硫磺粉碎过100目筛；
S2.再将苦参、土槿皮加水煎煮两次，并合并煎液，浓缩至稠膏状；
S3.再加入酮康唑、医用煤焦油、甲基纤维素、海藻酸钠、麦芽糊精、尼泊尔金以及上述的粉碎物并混合均匀，即得到该祛头屑治顽癣瘙痒的膏剂；
S4.最后对制备的膏剂进行称重、定量内外包装即可。
实施例2：
本发明实施例提供一种祛头屑治顽癣瘙痒的膏剂，按重量份计，其由如下原材料组成：苦参100份、地肤子20份、蛇床子20份、花椒10份、土槿皮30份、白鲜皮20份、硫磺50份、酮康唑10份、医用煤焦油10份、甲基纤维素5份、海藻酸钠1份、麦芽糊精5份、尼泊尔金1份、香精2份、色素1份、去离子水80份，所述膏剂呈液体膏状。
祛头屑治顽癣瘙痒的膏剂的制备方法与实施例1相同。
实施例3：
本发明实施例提供一种祛头屑治顽癣瘙痒的膏剂，按重量份计，其由如下原材料组成：苦参95份、地肤子15份、蛇床子15份、花椒8份、土槿皮25份、白鲜皮15份、硫磺45份、酮康唑9份、医用煤焦油11份、甲基纤维素6份、海藻酸钠0.8份、麦芽糊精6份、尼泊尔金0.8份、香精1.5份、色素0.7份、去离子水85份，所述膏剂呈液体膏状。
祛头屑治顽癣瘙痒的膏剂的制备方法与实施例1相同。
实施例4：
本发明实施例提供一种祛头屑治顽癣瘙痒的膏剂，按重量份计，其由如下原材料组成：苦参110份、地肤子30份、蛇床子30份、花椒15份、土槿皮40份、白鲜皮30份、硫磺60份、酮康唑15份、医用煤焦油15份、甲基纤维素8份、海藻酸钠1.5份、麦芽糊精8份、尼泊尔金1.5份、香精3份、色素1.5份、去离子水90份，所述膏剂呈液体膏状。
祛头屑治顽癣瘙痒的膏剂的制备方法与实施例1相同。
一、刺激性检测
对实施例1～4制得的膏剂进行取样，将其适用涂于100个年龄在18～50岁的志愿者的手背上，观察30min，看其是否出现红肿、起疹、起泡等过敏现象。
观察结果表明：在30min内所有志愿者均未出现任何过敏现象，说明该祛头屑治顽癣瘙痒的膏剂温和无刺激，不会对皮肤产生刺激及过敏问题。
二、去头屑效果
选取存在头屑及头皮瘙痒问题的志愿者400名，随机分为7组，每组100名，分别使用实施例1～4制得的膏剂，使用后对膏剂的去屑止痒效果进行评价。
去屑效果根据头屑的多少和大小来评分，止痒效果根据头痒开始的时间和头痒的程度来评分。评价周期为4周，评价采用5分制，5分为最高分，1分为最低分，分数越高代表效果越好。评价结果见下表1。
表1 去屑止痒性能测试结果
| 项目 | 清洁度 | 柔顺度 | 保湿性 | 去屑性 | 泡沫丰富度 |
| 实施例1 | 4.95 | 4.94 | 4.94 | 4.93 | 4.94 |
| 实施例2 | 4.96 | 4.96 | 4.95 | 4.97 | 4.96 |
| 实施例3 | 4.94 | 4.93 | 4.92 | 4.91 | 4.93 |
| 实施例4 | 4.91 | 4.92 | 4.91 | 4.90 | 4.91 |
从表1的结果可以看出，实施例2的祛头屑治顽癣瘙痒的膏剂的去屑止痒效果明显更好，该膏剂中采用的天然提取物中各组分间存在协同作用，采用合适的原料配比制作的膏剂去头屑效果更显著。
三、抑菌效果
分别测试实施例1～4制得的膏剂的抑菌性能，菌种由中国皮肤病研究院提供。测试方法：采用抑菌环法进行抑菌效果检测，所用菌株为糠秕马拉色标准菌株(Malasseziafurfur ATCC 44344)，所用培养基为Leeming&Notman琼脂培养基，测试结果参见下表2。
表2 去屑止痒性能测试结果
| 项目 | 细菌直径 |
| 实施例1 | 19.3 |
| 实施例2 | 15.8 |
| 实施例3 | 18.1 |
| 实施例4 | 14.3 |
从表2的抑菌效果可以看出，实施例1～4的洗发膏对马拉色菌均具有较好的抑制效果，且原料配比中的质量越大，对马拉色菌的抑制效果越好，并且天然提取物中各组分复配会产生协同作用，对马拉色菌的抑制效果更显著。
尽管已经示出和描述了本发明的实施例，对于本领域的普通技术人员而言，可以理解在不脱离本发明的原理和精神的情况下可以对这些实施例进行多种变化、修改、替换和变型，本发明的范围由所附权利要求及其等同物限定。
Claims (8)
1.一种祛头屑治顽癣瘙痒的膏剂，其特征在于，按重量份计，其由如下原材料组成：苦参90-110份、地肤子10-30份、蛇床子10-30份、花椒5-15份、土槿皮20-40份、白鲜皮10-30份、硫磺40-60份、酮康唑5-15份、医用煤焦油5-15份、甲基纤维素3-8份、海藻酸钠0.5-1.5份、麦芽糊精3-8份、尼泊尔金0.5-1.5份、香精1-3份、色素0.5-1.5份、去离子水70-90份，所述膏剂呈液体膏状。
2.根据权利要求1所述的一种祛头屑治顽癣瘙痒的膏剂，其特征在于，按重量份计，其由如下原材料组成：苦参90份、地肤子10份、蛇床子10份、花椒5份、土槿皮20份、白鲜皮10份、硫磺40份、酮康唑5份、医用煤焦油5份、甲基纤维素3份、海藻酸钠0.5份、麦芽糊精3份、尼泊尔金0.5份、香精1份、色素0.5份、去离子水70份，所述膏剂呈液体膏状。
3.根据权利要求1所述的一种祛头屑治顽癣瘙痒的膏剂，其特征在于，按重量份计，其由如下原材料组成：苦参100份、地肤子20份、蛇床子20份、花椒10份、土槿皮30份、白鲜皮20份、硫磺50份、酮康唑10份、医用煤焦油10份、甲基纤维素5份、海藻酸钠1份、麦芽糊精5份、尼泊尔金1份、香精2份、色素1份、去离子水80份，所述膏剂呈液体膏状。
4.根据权利要求1所述的一种祛头屑治顽癣瘙痒的膏剂，其特征在于，按重量份计，其由如下原材料组成：苦参95份、地肤子15份、蛇床子15份、花椒8份、土槿皮25份、白鲜皮15份、硫磺45份、酮康唑9份、医用煤焦油11份、甲基纤维素6份、海藻酸钠0.8份、麦芽糊精6份、尼泊尔金0.8份、香精1.5份、色素0.7份、去离子水85份，所述膏剂呈液体膏状。
5.根据权利要求1所述的一种祛头屑治顽癣瘙痒的膏剂，其特征在于，按重量份计，其由如下原材料组成：苦参110份、地肤子30份、蛇床子30份、花椒15份、土槿皮40份、白鲜皮30份、硫磺60份、酮康唑15份、医用煤焦油15份、甲基纤维素8份、海藻酸钠1.5份、麦芽糊精8份、尼泊尔金1.5份、香精3份、色素1.5份、去离子水90份，所述膏剂呈液体膏状。
6.根据权利要求1所述的一种祛头屑治顽癣瘙痒的膏剂，其特征在于，所述香精为玫瑰香精、桃花香精、茉莉香精、苹果香精、薰衣草香精中的一种或多种。
7.根据权利要求1所述的一种祛头屑治顽癣瘙痒的膏剂，其特征在于，所述色素的颜色为蓝色、红色、黄色或粉色。
8.根据权利要求1～7任一项所述的祛头屑治顽癣瘙痒的膏剂制备方法，其特征在于，包括以下步骤：
S1.先将白鲜皮、地肤子、蛇床子、花椒、硫磺粉碎过100目筛；
S2.再将苦参、土槿皮加水煎煮两次，并合并煎液，浓缩至稠膏状；
S3.再加入酮康唑、医用煤焦油、甲基纤维素、海藻酸钠、麦芽糊精、尼泊尔金以及上述的粉碎物并混合均匀，即得到该祛头屑治顽癣瘙痒的膏剂；
S4.最后对制备的膏剂进行称重、定量内外包装即可。
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| WO2024052756A1 (en) * | 2022-09-09 | 2024-03-14 | Crodarom | Use of an extract of sichuan pepper for a skin treatment and a composition suitable for this use. |
| FR3139466A1 (fr) * | 2022-09-09 | 2024-03-15 | Crodarom | Utilisation d’un extrait de poivrier de Sichuan pour un traitement cutané et une composition adaptée à cette utilisation. |
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