CN114555594B - 作为trmp8调节剂的取代的氮杂环 - Google Patents

作为trmp8调节剂的取代的氮杂环 Download PDF

Info

Publication number
CN114555594B
CN114555594B CN202080072667.6A CN202080072667A CN114555594B CN 114555594 B CN114555594 B CN 114555594B CN 202080072667 A CN202080072667 A CN 202080072667A CN 114555594 B CN114555594 B CN 114555594B
Authority
CN
China
Prior art keywords
imidazol
piperidin
propan
methylthio
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202080072667.6A
Other languages
English (en)
Chinese (zh)
Other versions
CN114555594A (zh
Inventor
N·科塞托阿玛尼诺
A·鲍姆伯恩
柴安
J·沙尔庞捷
C·陈
R·埃姆特
M·马塞斯
A·纳特施
C·王
周丽君
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Givaudan SA
Original Assignee
Givaudan SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Givaudan SA filed Critical Givaudan SA
Publication of CN114555594A publication Critical patent/CN114555594A/zh
Application granted granted Critical
Publication of CN114555594B publication Critical patent/CN114555594B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
    • A61K2800/24—Thermal properties
    • A61K2800/244—Endothermic; Cooling; Cooling sensation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/09—Geometrical isomers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Birds (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Hydrogenated Pyridines (AREA)
  • Steroid Compounds (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Laser Surgery Devices (AREA)
CN202080072667.6A 2019-10-17 2020-10-15 作为trmp8调节剂的取代的氮杂环 Active CN114555594B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2019111690 2019-10-17
CNPCT/CN2019/111690 2019-10-17
PCT/EP2020/079009 WO2021074281A1 (en) 2019-10-17 2020-10-15 Substituted azacyles as trmp8 modulators

Publications (2)

Publication Number Publication Date
CN114555594A CN114555594A (zh) 2022-05-27
CN114555594B true CN114555594B (zh) 2025-03-18

Family

ID=72964655

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080072667.6A Active CN114555594B (zh) 2019-10-17 2020-10-15 作为trmp8调节剂的取代的氮杂环

Country Status (10)

Country Link
US (2) US12528801B2 (enExample)
EP (1) EP4045491A1 (enExample)
JP (1) JP7778688B2 (enExample)
KR (1) KR20220085798A (enExample)
CN (1) CN114555594B (enExample)
BR (1) BR112022005289A2 (enExample)
CO (1) CO2022004130A2 (enExample)
IL (1) IL292156B2 (enExample)
MX (1) MX2022003494A (enExample)
WO (1) WO2021074281A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB202012170D0 (en) * 2020-08-05 2020-09-16 Givaudan Sa Organic compounds
GB202013383D0 (en) * 2020-08-26 2020-10-07 Givaudan Sa Process
WO2022170519A1 (en) 2021-02-09 2022-08-18 Givaudan Sa Organic compounds
GB202102676D0 (en) 2021-02-25 2021-04-14 Givaudan Sa Compositions
GB202103207D0 (en) 2021-03-08 2021-04-21 Givaudan Sa Organic compounds
GB202105661D0 (en) 2021-04-21 2021-06-02 Givaudan Sa Organic compounds
US20240238183A1 (en) 2021-05-28 2024-07-18 Firmenich Incorporated Compositions that enhance the cooling effect
CN117813077A (zh) * 2021-08-16 2024-04-02 西姆莱斯股份公司 组合物
US20250387310A1 (en) 2022-07-07 2025-12-25 Firmenich Incorporated Compositions that enhance the cooling effect
EP4554572A2 (en) 2022-07-11 2025-05-21 Symrise AG Mixtures and uses of (2e)-3-(1,3-benzodioxol-5-yl)-n-phenyl-n-(tetrahydro-3-furanyl)-2-propenamide
JP2026512978A (ja) 2022-10-27 2026-04-22 フイルメニツヒ ソシエテ アノニム フラボノイド組成物およびその使用
US20260206810A1 (en) 2022-12-22 2026-07-23 Firmenich Sa Natural sweetener compositions and uses thereof
US20260206809A1 (en) 2022-12-22 2026-07-23 Firmenich Sa Natural sweetener compositions containing alkyl lactates and uses thereof
JP2026511252A (ja) 2023-03-28 2026-04-10 フイルメニツヒ ソシエテ アノニム 味改変組成物およびその使用
EP4774272A1 (en) 2023-09-04 2026-07-15 Symrise AG Trpm8 modulators and related method for modulating trpm8 receptors
GB202315636D0 (en) 2023-10-12 2023-11-29 Givaudan Sa Composition
WO2025132323A1 (en) 2023-12-21 2025-06-26 Dsm-Firmenich Ag Compositions comprising a sunscreen active agent
WO2026052684A1 (en) 2024-09-04 2026-03-12 Givaudan Sa Flavour compositions
WO2026087386A1 (en) 2024-10-24 2026-04-30 Firmenich Sa Rosin diester compounds and uses thereof
WO2026092819A1 (en) 2024-10-28 2026-05-07 Symrise Ag Oral care compositions

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998040400A1 (en) * 1997-03-10 1998-09-17 Basf Aktiengesellschaft Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the c-terminus
WO2002036116A2 (en) * 2000-10-30 2002-05-10 Janssen Pharmaceutica N.V. Tripeptidyl peptidase inhibitors
EP3315492A1 (en) * 2015-06-23 2018-05-02 Kissei Pharmaceutical Co., Ltd. Pyrazole derivative, or pharmaceutically acceptable salt thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3988433A (en) 1973-08-10 1976-10-26 The Procter & Gamble Company Oral compositions for preventing or removing stains from teeth
US4083955A (en) 1975-04-02 1978-04-11 The Procter & Gamble Company Processes and compositions for remineralization of dental enamel
US4528180A (en) 1983-03-01 1985-07-09 Schaeffer Hans A Dental preparation, article and method for storage and delivery thereof
US4849213A (en) 1983-03-01 1989-07-18 Schaeffer Hans A Dental preparation, article and method for storage and delivery therof
US5198220A (en) 1989-11-17 1993-03-30 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
US5145666A (en) 1991-10-23 1992-09-08 The Proctor & Gamble Co. Methods of reducing plaque and gingivitis with reduced staining
US5213790A (en) 1991-10-23 1993-05-25 The Procter & Gamble Co. Methods of reducing plaque and gingivitis with reduced staining
US5281410A (en) 1991-10-23 1994-01-25 The Proctor & Gamble Company Methods of reducing plaque and gingivitis with reduced staining
US5242910A (en) 1992-10-13 1993-09-07 The Procter & Gamble Company Sustained release compositions for treating periodontal disease
HUP0500921A2 (en) 2005-10-05 2007-07-30 Richter Gedeon Nyrt Tetrazole derivatives, process for their preparation and their use
HUP0500920A2 (en) * 2005-10-05 2007-07-30 Richter Gedeon Nyrt Oxadiazole derivatives, process for their preparation and their use
GB0704163D0 (en) 2007-03-02 2007-04-11 Quest Int Serv Bv Compositions comprising a physiological coolant
EP2331499B1 (en) * 2008-08-19 2016-09-21 Janssen Pharmaceutica NV Cold menthol receptor antagonists
AU2009318056B2 (en) 2008-11-20 2014-07-24 The Procter & Gamble Company Personal care compositions providing enhanced cooling sensation
CN103201279A (zh) 2010-11-05 2013-07-10 赛诺米克斯公司 作为trpm8的调节剂有用的化合物
WO2014037340A1 (de) 2012-09-05 2014-03-13 Bayer Cropscience Ag Verwendung substituierter 2-amidobenzimidazole, 2-amidobenzoxazole und 2-amidobenzothiazole oder deren salze als wirkstoffe gegen abiotischen pflanzenstress
CN106103416B (zh) 2014-03-14 2021-03-02 拉夸里亚创药株式会社 作为trpm8拮抗剂的氮杂螺衍生物
EP3675809B1 (de) 2017-08-31 2023-09-27 Basf Se Verwendung physiologischer kühlwirkstoffe und mittel enthaltend solche wirkstoffe
EP3658109B1 (en) 2017-12-21 2022-12-07 Firmenich SA Cooling and flavor boosting compositions

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998040400A1 (en) * 1997-03-10 1998-09-17 Basf Aktiengesellschaft Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the c-terminus
WO2002036116A2 (en) * 2000-10-30 2002-05-10 Janssen Pharmaceutica N.V. Tripeptidyl peptidase inhibitors
EP3315492A1 (en) * 2015-06-23 2018-05-02 Kissei Pharmaceutical Co., Ltd. Pyrazole derivative, or pharmaceutically acceptable salt thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Rationale, Design, and Synthesis of Novel Phenyl Imidazoles as Opioid Receptor Agonists for Gastrointestinal Disorders;Henry J. Breslin等;J. Med. Chem.;第47卷(第21期);第5009–5020页，sheme 1 *
Transient Receptor Potential Melastatin 8 Channel (TRPM8) Modulation: Cool Entryway for Treating Pain and Cancer;M. Jesús Pérez de Vega等;Journal of Medicinal Chemistry;第59卷;第10006-10029页 *

Also Published As

Publication number Publication date
JP7778688B2 (ja) 2025-12-02
KR20220085798A (ko) 2022-06-22
US12528801B2 (en) 2026-01-20
JP2022552401A (ja) 2022-12-15
MX2022003494A (es) 2022-04-25
US20240132487A1 (en) 2024-04-25
EP4045491A1 (en) 2022-08-24
CN114555594A (zh) 2022-05-27
IL292156A (en) 2022-06-01
WO2021074281A1 (en) 2021-04-22
BR112022005289A2 (pt) 2022-09-20
US20260103459A1 (en) 2026-04-16
CO2022004130A2 (es) 2022-07-08
IL292156B2 (en) 2026-05-01
IL292156B1 (en) 2026-01-01

Similar Documents

Publication Publication Date Title
JP7778688B2 (ja) Ｔｒｍｐ８モジュレーターとしての置換アザシル
TW568897B (en) Aminobutanoic acid derivatives
CN116867775A (zh) 作为trpm8激活剂的有机化合物
JP7835730B2 (ja) 冷却感覚組成物
TW200902019A (en) Dicyclic heterocyclic compound
JP2025506364A (ja) 新規クーラントおよびそれを含有する調製物
CN114761385B (zh) Trpm8调节剂
CN115243764B (zh) 作为trmp8拮抗剂的杂环衍生物
RU2839995C1 (ru) Замещенные азацилы в качестве модуляторов trpm8
BR112018006563B1 (pt) Método para preparar um derivado de nmentanocarboxamida úteis como elementos sensoriais nos produtos destinados ao consumidor
WO2026052684A1 (en) Flavour compositions
EP4326711A1 (en) Compounds with cooling sensation properties
CN121568927A (zh) 作为生理清凉剂的杂环化合物

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant