CN114533559A - Method and equipment for preparing soft capsule - Google Patents
Method and equipment for preparing soft capsule Download PDFInfo
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- CN114533559A CN114533559A CN202210380034.2A CN202210380034A CN114533559A CN 114533559 A CN114533559 A CN 114533559A CN 202210380034 A CN202210380034 A CN 202210380034A CN 114533559 A CN114533559 A CN 114533559A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/078—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of wafers or cachets
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Abstract
The invention discloses a method for preparing soft capsules, which comprises the following steps: preparing glue solution, namely coating the prepared glue solution on a rubber wheel and cooling the glue solution into rubber; preparing a chemical solution according to actual needs, and supplying the chemical solution to the spray body; providing the rubber on the rolling die, and simultaneously heating the spray body to spray the liquid medicine; shaping, cooling and shaping the soft capsule; cleaning, namely cleaning the soft capsules by using non-woven fabrics; drying, namely drying by a roller dryer; collecting soft capsules; and (6) recovering the rubber net. The invention has the following technical effects: the quality of the soft capsule is improved by the whole-process integrated treatment.
Description
Technical Field
The invention belongs to the field of soft capsule preparation, and particularly relates to a method and equipment for preparing a soft capsule.
Background
Because of its many advantages, soft capsules are widely used in the pharmaceutical industry, and although the manufacturing method is always improved, the quality problem of soft capsules still remains endlessly.
Typical soft capsules are made as follows:
CN114081836A an intelligent soft capsule production device,
CN215841750U A defoaming device for soft capsule production,
CN215852186U A conveying mechanism for soft capsule production line,
CN114053243A A Enzalutamide soft capsule and its preparation method,
CN114028357A A soft capsule of pulullan polysaccharide and its preparation method,
CN113975361A A Chinese medicinal soft capsule containing oleum Amomi and its preparation method,
however, the existing capsules have defects in pressing, shaping, cleaning and drying, so that the quality of the produced finished products also has problems, and the cited patent documents can not solve the problems well.
Disclosure of Invention
In view of the above technical problems, the present invention provides a method and an apparatus for manufacturing a soft capsule, which can solve the problems in the prior art.
In order to solve the technical problems, the technical scheme of the invention is as follows:
a method for preparing soft capsules comprises the following steps:
preparing glue solution, namely coating the prepared glue solution on a rubber wheel and cooling the glue solution into rubber;
preparing a chemical solution according to actual needs, and supplying the chemical solution to the spray body;
providing the rubber on the rolling die, and simultaneously heating the spray body to spray the liquid medicine;
shaping, cooling and shaping the soft capsule;
cleaning, namely cleaning the soft capsules by using non-woven fabrics;
drying, namely drying by a roller dryer;
collecting soft capsules;
and (6) recovering the rubber net.
Further, the glue solution is formed by heating and stirring gelatin, glycerin and water.
Further, the liquid medicine contains ganoderma lucidum spore oil.
Further, the shaping adopts an air cooling type.
Further, the cleaning is performed by using ethanol.
Further, the cleaning is carried out by adopting a pill wiping machine.
Further, the drying adopts a tray type drying mode.
Further, the drying adopts a rolling cage type drying mode.
Further, the recovered rubber net is added into the preparation of the rubber solution in proportion.
The invention has the following technical effects: the quality of the soft capsule is improved by the whole-process integrated treatment.
Drawings
FIG. 1 is a flow chart of the preparation of the soft capsule of the present invention;
FIG. 2 is a schematic view showing the construction of the soft capsule manufacturing apparatus of the present invention;
FIG. 3 is a partial cross-sectional view of the pellet-forming apparatus of the present invention;
FIG. 4 is an enlarged view of portion A of FIG. 2 of the present invention;
FIG. 5 is an enlarged view of portion B of FIG. 2 in accordance with the present invention;
FIG. 6 is a schematic view of the structure of the roll platen of the present invention;
FIG. 7 is a cross-sectional view of the roll platen of the present invention (embodiment one);
FIG. 8 is a sectional view of the roll platen of the present invention (example II);
FIG. 9 is a schematic view and a partial enlarged view of the roller die supporting roller according to the present invention;
FIG. 10 is a front view of a roll platen according to a second embodiment of the present invention;
FIG. 11 is a rear view of the roll platen according to the second embodiment of the present invention;
FIG. 12 is an exploded view of a third embodiment of the present invention;
FIG. 13 is a schematic view of the process for forming the soft capsule of the present invention;
in the figure, a rubber sheet supply device 1, a liquid medicine supply device 2, a spray body 3, a pellet press shaping device 4, a conveying device 5, an air suction fan 6, an exhaust fan 7, an upper support roller 8, a lower support roller 9, a rolling die chain plate 10, a support rod 11, a shaping fan 12, a driving motor 13, a driving gear 14, a driven gear 15, a transmission chain 16, a cleaning head 17, a balancing weight 18 (with a large mass), a rolling die pressing plate 19, a forming part 20, a containing cavity 20.1, a pressing die 20.2, a connecting end 21, a first connecting end 21.1, a second connecting end 21.2, a groove 22, a through hole 23, a first through hole 23.1, a second through hole 23.2, a roller body 24, a convex strip 25, a connecting shaft 26, a containing groove 27, a fixed end 28 and a soft capsule 29 are shown.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
In the description of the present invention, it is to be understood that the terms "center", "length", "width", "thickness", "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", "axial", "circumferential", and the like, indicate orientations and positional relationships based on those shown in the drawings, and are used merely for convenience of description and for simplicity of description, and do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, should not be considered as limiting the present invention.
In the present invention, unless otherwise expressly specified or limited, the terms "disposed," "mounted," "connected," and "fixed" are to be construed broadly and may, for example, be fixedly connected or detachably connected; may be a mechanical connection; may be directly connected or indirectly connected through an intermediate. The specific meanings of the above terms in the present invention can be understood by those skilled in the art according to specific situations.
Furthermore, the terms "first", "second", etc. are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature.
The invention discloses a method and equipment for preparing soft capsules, as shown in figure 1, the method for preparing the soft capsules comprises the following steps:
step 1: preparing glue solution, namely coating the prepared glue solution on a rubber wheel and cooling the glue solution into rubber;
step 2: preparing a chemical solution according to actual needs, and supplying the chemical solution to the spray body;
and step 3: providing the rubber on the rolling die, and simultaneously heating the spray body to spray the liquid medicine;
and 4, step 4: shaping, cooling and shaping the soft capsule;
and 5: cleaning, namely cleaning the soft capsules by using non-woven fabrics;
step 6: drying, namely drying by a roller dryer;
and 7: collecting soft capsules;
and 8: and (6) recovering the rubber net.
The glue solution is formed by heating and stirring gelatin, glycerin, water and other required substances (belonging to the mode in the prior art); the liquid medicine contains ganoderma lucidum spore oil, lycopene, an emulsifier and an auxiliary emulsifier, and the liquid medicine comprises the following components in a volume ratio of 4: 5: 1, an emulsifier and a co-emulsifier, wherein the mixed oil phase comprises a mixture of 1: lycopene and ganoderma spore oil of 7.6. Wherein the emulsifier is caprylic/capric polyethylene glycol glyceride, and the co-emulsifier is PEG-400. The shaping adopts an air cooling type; the cleaning is carried out by adopting ethanol or a pill wiping machine; and the drying adopts a tray type drying mode or a rolling cage type drying mode.
The soft capsule manufacturing equipment comprises a rubber supply device 1, a liquid medicine supply device 2, a spray body 3, a pellet press shaping device 4, a conveying device 5, a cleaning device and a drying device, wherein all the devices are fixedly arranged on a support frame and are not shown in the figure.
As shown in fig. 2, a schematic view of a part of the apparatus of the manufacturing apparatus of the present invention is shown (the support frame is omitted); as shown in fig. 2 and 3, the pellet press-setting device 4 has a casing, and an air suction fan 6 is provided on a front side surface of the casing, and the air suction fan 6 is used for blowing low-temperature air into the casing; an exhaust fan 7 is disposed at the rear side of the housing, and the exhaust fan 7 is used for exhausting the air inside the housing to the outside.
As shown in fig. 3, two sets of rolling dies are symmetrically arranged inside the housing, and the soft capsule 29 is formed by pressing the two sets of rolling dies on the inner side of the upper end. The rolling die is provided with an upper supporting roller 8 supported on the upper part of the shell and a lower supporting roller 9 supported on the lower part of the shell, and the upper supporting roller 8 and the lower supporting roller 9 are identical in structure and are provided with roller bodies 24. Go up on supporting roller 8 and the lower supporting roller 9 around being equipped with the rolling die link joint 10, the inside of casing is provided with a plurality of setting fans 12 through bracing piece 11, setting fan 12 sets up the inboard at every group rolling die, and all towards the inboard rolling die link joint 10 blast air for set soft capsule 29 on the rolling die link joint 10.
As shown in fig. 3 and 4, the rolling die chain plate 10 is composed of a plurality of rolling die units, and soft capsules 29 are formed on the rolling die units in mutual pressing mode.
In one embodiment, as shown in fig. 6 and 7, the rolling die unit has a rolling die pressing plate 19, a forming part 20 is provided on the front side of the rolling die pressing plate 19, the rolling die units are pressed against each other, and soft capsules 29 are formed in the forming part 20. The upper end and the lower end of the rolling die pressing plate 19 are provided with connecting ends 21 (as shown in fig. 6), and the rear side surface of the rolling die pressing plate 19 is provided with a groove 22 for positioning. (in another embodiment, as shown in fig. 8, 10 and 11, the bottom of the forming part 20 may be further opened with a through hole 23, when the through hole 23 is opened, the effect and speed of shaping the shaping fan 12 can be improved). The outside of the roll body 24 of the upper supporting roll 8 and the lower supporting roll 9 is provided with a raised line 25 matched with the groove 22, the connecting end 21 comprises a first connecting end 21.1 and a second connecting end 21.2, and the rolling die units are connected end to end with each other through a connecting shaft 26.
In another embodiment, as shown in fig. 12, a containing cavity 20.1 is formed on the front side surface of the rolling die pressing plate 19, a first through hole 23.1 is opened at the bottom of the containing cavity 20.1, the containing cavity 20.1 is used for containing a pressing die 20.2, a second through hole 23.2 corresponding to the first through hole 23.1 is opened at the bottom of the pressing die 20.2, the rolling die units are connected end to end with each other through a connecting shaft 26, a containing groove 27 is opened at the edge of the containing cavity 20.1, and a fixing end 28 fixed in the containing groove 27 is arranged on the pressing die 20.2. Each forming part is detachably arranged, so that the forming parts can be replaced when damaged, the service life of the roller body is prolonged, and the forming effect and speed of the forming fan 12 can be improved.
As shown in fig. 3 and 5, a driving motor 13 is fixed on the outer side of the left and right sides of the housing, a driving gear 14 and a plurality of driven gears 15 are fixed on the inner side of the left and right sides of the housing, a driving chain 16 is wound on the driving gear 14 and the driven gears 15, a driving shaft of the driving motor 13 passes through the housing to be connected with the driving gear 14, the driving force is transmitted to the driven gears 15 under the action of the driving chain 16, a cleaning head 17 is arranged on each of the driving gear 14 and the driven gears 15, a counterweight block 18 is arranged on one side of the end of the cleaning head 17, when the driving motor 13 is turned on, the cleaning head 17 can rotate to clean the roller die, and because the counterweight block is arranged on one side, the head of the cleaning head 17 is in a swinging state during cleaning, both the inner side and the outer side of the chain plate of the forming part 20 on the roller die 10 can be cleaned, the oscillation can enhance the cleaning effect.
It is important to emphasize that the traditional rolling die is designed into a chain structure, not only for the purpose of making each die part on the rolling die independent, but also for replacement and maintenance; and most importantly, the chain type rolling die can be shaped before falling to the conveying device 5, so that collision is avoided or reduced, the forming effect of the soft capsules 29 is improved, and the quality of the soft capsules 29 is further improved. Fig. 12 shows the process of the chain-structured roll-forming of the present invention, and the soft capsules 29 are not completely formed at the position P1 as shown in fig. 12, and thus are not shown. Because the two pairs of rolling die units are in a pressing relationship, the pelleting process of the pair of rolling die units is started from the position P1 to the position P7, and the dropping of the soft capsules 29 is finished. Starting from the position P2, the soft capsule 29 is formed, and due to the pressing, the soft capsule 29, which is circular, is lowered a small distance inside when the soft capsule 29 is opened at the P3 position (the position of the roller mold unit just leaving the upper support roller 8) by a distance d1 on the lower side as shown in the enlarged view; the return at position P4, i.e. the reduction in distance d1, will lift softgel 29 upwards, whereby softgel 29 will move a small distance inside; in the position P5 (which is the position of the roller die unit just before entering the lower supporting roller 9), the upper side is opened by a distance d2 as shown in the enlarged view, and the soft capsule 29 is pushed inside; therefore, demolding is realized, the demolding effect is improved, and the shaping fan can achieve a good shaping effect (the shaping effect of increasing the through holes is better) in the process. The soft capsule 29 should not move too far inside, which could result in the surface of the soft capsule being damaged by the uncommitted shape.
Be the chain structure with the setting of suppression softgel device, change moulding-die that not only can be convenient, like fig. 12, the softgel that preliminary suppression is can have on the chain to reciprocate moreover, combines the fan, improves the effect of setting and drawing of patterns, has solved among the prior art setting and the not good problem of drawing of patterns effect.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the invention.
Claims (9)
1. A method for preparing soft capsules is characterized by comprising the following steps: the preparation method of the soft capsule comprises the following steps:
preparing glue solution, namely coating the prepared glue solution on a rubber wheel and cooling the glue solution into rubber;
preparing a chemical solution according to actual needs, and supplying the chemical solution to the spray body;
providing the rubber on the rolling die, and simultaneously heating the spray body to spray the liquid medicine;
shaping, cooling and shaping the soft capsule;
cleaning, namely cleaning the soft capsules by using non-woven fabrics;
drying, namely drying by a roller dryer;
collecting soft capsules;
and (6) recovering the rubber net.
2. The method for preparing a soft capsule according to claim 1, wherein: the glue solution is formed by heating and stirring gelatin, glycerin and water.
3. The method for preparing a soft capsule according to claim 1, wherein: the liquid medicine contains Ganoderma spore oil.
4. The method for preparing a soft capsule according to claim 1, wherein: the shaping adopts an air cooling type.
5. The method for preparing a soft capsule according to claim 1, wherein: the cleaning is performed by using ethanol.
6. The method for preparing a soft capsule according to claim 1, wherein: the cleaning is carried out by adopting a pill wiping machine.
7. The method for preparing a soft capsule according to claim 1, wherein: the drying adopts a tray type drying mode.
8. The method for preparing a soft capsule according to claim 1, wherein: the drying adopts a rolling cage type drying mode.
9. The method for preparing a soft capsule according to claim 1, wherein: the recovered rubber net is added into the preparation of the rubber solution according to a proportion.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210380034.2A CN114533559B (en) | 2022-04-12 | 2022-04-12 | Method and equipment for preparing soft capsules |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210380034.2A CN114533559B (en) | 2022-04-12 | 2022-04-12 | Method and equipment for preparing soft capsules |
Publications (2)
| Publication Number | Publication Date |
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| CN114533559A true CN114533559A (en) | 2022-05-27 |
| CN114533559B CN114533559B (en) | 2023-04-21 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN202210380034.2A Active CN114533559B (en) | 2022-04-12 | 2022-04-12 | Method and equipment for preparing soft capsules |
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523652A (en) * | 2014-12-25 | 2015-04-22 | 新疆大学 | Method for producing lycopene soft capsule |
| CN206198308U (en) * | 2016-07-18 | 2017-05-31 | 浙江亚利大胶丸有限公司 | A kind of capsule press |
| CN108904550A (en) * | 2018-07-19 | 2018-11-30 | 深圳极醇健康产业股份有限公司 | A kind of G. lucidum spores Softgel and preparation method thereof |
| CN210494627U (en) * | 2018-12-27 | 2020-05-12 | 杭州百芮生物科技有限公司 | Production equipment for soft capsules with rubber recycled |
| CN211535679U (en) * | 2019-08-05 | 2020-09-22 | 华润三九（南昌）药业有限公司 | Soft capsule machine |
| CN114081836A (en) * | 2022-01-21 | 2022-02-25 | 江苏如东高新生物科技有限公司 | Soft capsule intelligent production equipment |
-
2022
- 2022-04-12 CN CN202210380034.2A patent/CN114533559B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104523652A (en) * | 2014-12-25 | 2015-04-22 | 新疆大学 | Method for producing lycopene soft capsule |
| CN206198308U (en) * | 2016-07-18 | 2017-05-31 | 浙江亚利大胶丸有限公司 | A kind of capsule press |
| CN108904550A (en) * | 2018-07-19 | 2018-11-30 | 深圳极醇健康产业股份有限公司 | A kind of G. lucidum spores Softgel and preparation method thereof |
| CN210494627U (en) * | 2018-12-27 | 2020-05-12 | 杭州百芮生物科技有限公司 | Production equipment for soft capsules with rubber recycled |
| CN211535679U (en) * | 2019-08-05 | 2020-09-22 | 华润三九（南昌）药业有限公司 | Soft capsule machine |
| CN114081836A (en) * | 2022-01-21 | 2022-02-25 | 江苏如东高新生物科技有限公司 | Soft capsule intelligent production equipment |
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| CN114533559B (en) | 2023-04-21 |
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