CN108904550A - A kind of G. lucidum spores Softgel and preparation method thereof - Google Patents
A kind of G. lucidum spores Softgel and preparation method thereof Download PDFInfo
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- CN108904550A CN108904550A CN201810793574.7A CN201810793574A CN108904550A CN 108904550 A CN108904550 A CN 108904550A CN 201810793574 A CN201810793574 A CN 201810793574A CN 108904550 A CN108904550 A CN 108904550A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
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Abstract
The invention discloses a kind of G. lucidum spores Softgels and preparation method thereof, the present invention using ganoderma lucidum spore oil be primary raw material as content, softgel shell is made using gelatin, purified water, glycerol as auxiliary material, by pelleting, the operation such as be formed, wash ball, drying, pick ball, packaging, a kind of G. lucidum spores Softgel is prepared.Beneficial effect is：The present invention is using the ganoderma lucidum spore oil naturally extracted, ganoderma lucidum spore oil is the oily lipid extracted from the Reishi sporule of broken wall by supercritical carbon dioxide extraction technology, with antitumor, enhancing be immune and the multiple biological activities such as liver protecting, it is synthetically prepared using material without side-effects, harmful substance is not added in preparation process, for preparation process fully according to national standard, health is harmless, and immunity can be improved after taking.
Description
Technical field
The present invention relates to pharmaceutical manufacturing fields, more particularly to a kind of G. lucidum spores Softgel and preparation method thereof.
Background technique
Ganoderma lucidum spore oil is the oil extracted from the Reishi sporule of broken wall by supercritical carbon dioxide extraction technology
Shape lipid has antitumor, enhancing immune and the multiple biological activities such as liver protecting, with the tempo increase of life and work,
Social majority of populations come into sub-health state, but very insufficient for the investment of own health maintenance aspect, now such as
More chemical element is added in modern most of health medicines, although body immunity can be improved, also there are many pairs to make
With the present invention is synthetically prepared, in preparation process not using the ganoderma lucidum spore oil naturally extracted using material without side-effects
Harmful substance is added, for preparation process fully according to national standard, health is harmless, improves immunity after taking.
Summary of the invention
The object of the invention is that providing a kind of G. lucidum spores Softgel and its preparation to solve the above-mentioned problems
Immunity of human body itself can be improved in method, the present invention after usage.
The present invention is achieved through the following technical solutions above-mentioned purpose：
A kind of G. lucidum spores Softgel, the bulk pharmaceutical chemicals including following weight,
Ganoderma lucidum spore oil：150-250 parts；
Gelatin：50-70 parts；
Purified water：50-60 parts
Glycerol：20-30 parts.
Preferably, the G. lucidum spores Softgel, the bulk pharmaceutical chemicals including following weight,
Ganoderma lucidum spore oil：200 parts；
Gelatin：60 parts；
Purified water：54 parts
Glycerol：27 parts.
The preparation method of G. lucidum spores Softgel, includes the following steps：
It is spare as content feed liquid to weigh required ganoderma lucidum spore oil by formula for step 1；
Step 2 weighs glycerol, in purified water additionization glue tank by formula rate, and gelatin is added in heating, and stirring dissolves,
Degassing is vacuumized, is sieved with 100 mesh sieve, glue is injected to keep the temperature in insulation barrel and is placed, and visual examination bubble-free, as capsule shells material
Liquid is spare；
Content feed liquid and capsule shells feed liquid are carried out pelleting operation by pelleting device by step 3；
Sizing is dried to the material completed after pelleting is processed in step 4；
Step 5 carries out the capsule after completion patterning process to wash ball processing；
Processing is dried in step 6, the capsule washed after ball processing to completion；
Step 7 carries out the capsule completed after drying is processed to pick ball operation, and then dress operation is wrapped inside to capsule；
Step 8 carries out outer packing operation in production clean area to the Packaging Bottle for completing inner packing, and then to completion outsourcing
The capsule of dress operation carries out warehousing finished products.
Preferably, the temperature of the mixing glycerol heating of step 2 is 70 DEG C -80 DEG C.
Preferably, the vacuum outgas pressure of the mixing glycerol of step 2 is 0.06Mpa-0.08Mpa.
Preferably, the particle of the mixing glycerol of step 2 is less than 150 microns.
Preferably, temperature is 55 DEG C -65 DEG C in the insulation barrel of the mixing glycerol of step 2.
Preferably, the pelleting operation that step 3 carries out is limited in 0.5g to the weight of pill.
Preferably, drying temperature when patterning process is dried in step 4 is controlled at 18 DEG C -26 DEG C, and relative humidity controls
In 30%-40%.
It preferably, is -36 hours 24 hours to the drying time that the capsule of step 6 carries out, 24 DEG C -28 of dry temperature
DEG C, relative humidity 20%-30%.
Preferably, the bottling operation of step 7 is 60/bottle, and inner packing plastic bottle should meet《The medicinal height of oral administration solid
Density polyethylene bottle》(YBB00122002) standard requirements
Compared with the existing technology, advantages of the present invention is as follows：
1, the present invention carries out medicine preparation as raw material using natural material, pollution-free；
2, preparation process is implemented in strict accordance with national standard；
3, preparation process does not add any harmful substance, avoids the secondary injury to human body.
Specific embodiment
The present invention is further illustrated combined with specific embodiments below, but the invention is not limited to these to implement
Example.
Embodiment 1：
A kind of preparation method of G. lucidum spores Softgel：Include the following steps：
Composition of raw materials：Ganoderma lucidum spore oil：200 parts；Gelatin：60 parts；Purified water：54 parts of glycerol：27 parts；
It is spare as content feed liquid that required ganoderma lucidum spore oil is weighed by formula, is weighed glycerol by formula rate, is purified
In water additionization glue tank, 72 DEG C are heated to, gelatin is added, stirring dissolves, and vacuumizing degassing pressure is 0.062Mpa, crosses 100 mesh
Glue is injected to keep the temperature in insulation barrel and be placed by sieve, and holding temperature is 56 DEG C, spare as capsule shells feed liquid, by content feed liquid
Pelleting operation is carried out by pelleting device with capsule shells feed liquid, pelleting process control content is 0.5g, is processed to pelleting is completed
Sizing is dried in material later, and drying time is 26 hours, 25 DEG C of dry temperature, and relative humidity 24% is fixed to completing
Capsule after type processing carries out washing ball processing, and processing is dried in the capsule washed after ball processing to completion, to completion drying
Capsule after processing carries out picking ball operation, and then dress operation is wrapped inside to capsule, and bottling quantity is 60/bottle, to completion
The Packaging Bottle of inner packing carries out outer packing operation in production clean area, and then carries out finished product to the capsule for completing outer packing operation and enter
Library.
Embodiment 2：
A kind of preparation method of G. lucidum spores Softgel：Include the following steps：
Composition of raw materials：Ganoderma lucidum spore oil：210 parts；Gelatin：58 parts；Purified water：51 parts of glycerol：21 parts；
It is spare as content feed liquid that required ganoderma lucidum spore oil is weighed by formula, is weighed glycerol by formula rate, is purified
In water additionization glue tank, 70 DEG C are heated to, gelatin is added, stirring dissolves, and vacuumizing degassing pressure is 0.068Mpa, crosses 100 mesh
Glue is injected to keep the temperature in insulation barrel and be placed by sieve, and holding temperature is 58 DEG C, spare as capsule shells feed liquid, by content feed liquid
Pelleting operation is carried out by pelleting device with capsule shells feed liquid, pelleting process control content is 0.5g, is processed to pelleting is completed
Sizing is dried in material later, and drying time is 35 hours, 28 DEG C of dry temperature, and relative humidity 30% is fixed to completing
Capsule after type processing carries out washing ball processing, and processing is dried in the capsule washed after ball processing to completion, to completion drying
Capsule after processing carries out picking ball operation, and then dress operation is wrapped inside to capsule, and bottling quantity is 60/bottle, to completion
The Packaging Bottle of inner packing carries out outer packing operation in production clean area, and then carries out finished product to the capsule for completing outer packing operation and enter
Library.
Embodiment 3：
A kind of preparation method of G. lucidum spores Softgel：Include the following steps：
Composition of raw materials：Ganoderma lucidum spore oil：215 parts；Gelatin：56 parts；Purified water：59 parts of glycerol：25 parts；
It is spare as content feed liquid that required ganoderma lucidum spore oil is weighed by formula, is weighed glycerol by formula rate, is purified
In water additionization glue tank, 74 DEG C are heated to, gelatin is added, stirring dissolves, and vacuumizing degassing pressure is 0.08Mpa, crosses 100 mesh
Glue is injected to keep the temperature in insulation barrel and be placed by sieve, and holding temperature is 65 DEG C, spare as capsule shells feed liquid, by content feed liquid
Pelleting operation is carried out by pelleting device with capsule shells feed liquid, pelleting process control content is 0.5g, is processed to pelleting is completed
Sizing is dried in material later, and drying time is 27 hours, 26 DEG C of dry temperature, and relative humidity 22% is fixed to completing
Capsule after type processing carries out washing ball processing, and processing is dried in the capsule washed after ball processing to completion, to completion drying
Capsule after processing carries out picking ball operation, and then dress operation is wrapped inside to capsule, and bottling quantity is 60/bottle, to completion
The Packaging Bottle of inner packing carries out outer packing operation in production clean area, and then carries out finished product to the capsule for completing outer packing operation and enter
Library.
Embodiment 4：
A kind of preparation method of G. lucidum spores Softgel：Include the following steps：
Composition of raw materials：Ganoderma lucidum spore oil：220 parts；Gelatin：56 parts；Purified water：58 parts of glycerol：24 parts；
It is spare as content feed liquid that required ganoderma lucidum spore oil is weighed by formula, is weighed glycerol by formula rate, is purified
In water additionization glue tank, 80 DEG C are heated to, gelatin is added, stirring dissolves, and vacuumizing degassing pressure is 0.074Mpa, crosses 100 mesh
Glue is injected to keep the temperature in insulation barrel and be placed by sieve, and holding temperature is 62 DEG C, spare as capsule shells feed liquid, by content feed liquid
Pelleting operation is carried out by pelleting device with capsule shells feed liquid, pelleting process control content is 0.5g, is processed to pelleting is completed
Sizing is dried in material later, and drying time is 25 hours, 27 DEG C of dry temperature, and relative humidity 21% is fixed to completing
Capsule after type processing carries out washing ball processing, and processing is dried in the capsule washed after ball processing to completion, to completion drying
Capsule after processing carries out picking ball operation, and then dress operation is wrapped inside to capsule, and bottling quantity is 60/bottle, to completion
The Packaging Bottle of inner packing carries out outer packing operation in production clean area, and then carries out finished product to the capsule for completing outer packing operation and enter
Library.
Embodiment 5：
A kind of preparation method of G. lucidum spores Softgel：Include the following steps：
Composition of raw materials：Ganoderma lucidum spore oil：232 parts；Gelatin：54 parts；Purified water：52 parts of glycerol：27 parts；
It is spare as content feed liquid that required ganoderma lucidum spore oil is weighed by formula, is weighed glycerol by formula rate, is purified
In water additionization glue tank, 73 DEG C are heated to, gelatin is added, stirring dissolves, and vacuumizing degassing pressure is 0.07Mpa, crosses 100 mesh
Glue is injected to keep the temperature in insulation barrel and be placed by sieve, and holding temperature is 64 DEG C, spare as capsule shells feed liquid, by content feed liquid
Pelleting operation is carried out by pelleting device with capsule shells feed liquid, pelleting process control content is 0.5g, is processed to pelleting is completed
Sizing is dried in material later, and drying time is 36 hours, 24 DEG C of dry temperature, and relative humidity 23% is fixed to completing
Capsule after type processing carries out washing ball processing, and processing is dried in the capsule washed after ball processing to completion, to completion drying
Capsule after processing carries out picking ball operation, and then dress operation is wrapped inside to capsule, and bottling quantity is 60/bottle, to completion
The Packaging Bottle of inner packing carries out outer packing operation in production clean area, and then carries out finished product to the capsule for completing outer packing operation and enter
Library.
Embodiment 6：
A kind of preparation method of G. lucidum spores Softgel：Include the following steps：
Composition of raw materials：Ganoderma lucidum spore oil：248 parts；Gelatin：52 parts；Purified water：53 parts of glycerol：22 parts；
It is spare as content feed liquid that required ganoderma lucidum spore oil is weighed by formula, is weighed glycerol by formula rate, is purified
In water additionization glue tank, 79 DEG C are heated to, gelatin is added, stirring dissolves, and vacuumizing degassing pressure is 0.064Mpa, crosses 100 mesh
Glue is injected to keep the temperature in insulation barrel and be placed by sieve, and holding temperature is 58 DEG C, spare as capsule shells feed liquid, by content feed liquid
Pelleting operation is carried out by pelleting device with capsule shells feed liquid, pelleting process control content is 0.5g, is processed to pelleting is completed
Sizing is dried in material later, and drying time is 28 hours, 26 DEG C of dry temperature, and relative humidity 28% is fixed to completing
Capsule after type processing carries out washing ball processing, and processing is dried in the capsule washed after ball processing to completion, to completion drying
Capsule after processing carries out picking ball operation, and then dress operation is wrapped inside to capsule, and bottling quantity is 60/bottle, to completion
The Packaging Bottle of inner packing carries out outer packing operation in production clean area, and then carries out finished product to the capsule for completing outer packing operation and enter
Library.
The basic principles, main features and advantages of the invention have been shown and described above.The technical staff of the industry should
Understand, the present invention is not limited to the above embodiments, and the above embodiments and description only describe originals of the invention
Reason, without departing from the spirit and scope of the present invention, various changes and improvements may be made to the invention, these changes and improvements
It all fall within the protetion scope of the claimed invention.
Claims (11)
1. a kind of G. lucidum spores Softgel, it is characterised in that：Bulk pharmaceutical chemicals including following weight,
Ganoderma lucidum spore oil：150-250 parts；
Gelatin：50-70 parts；
Purified water：50-60 parts
Glycerol：20-30 parts.
2. a kind of G. lucidum spores Softgel according to claim 1, it is characterised in that：Including following weight
Bulk pharmaceutical chemicals,
Ganoderma lucidum spore oil：200 parts；
Gelatin：60 parts；
Purified water：54 parts
Glycerol：27 parts.
3. the preparation method of G. lucidum spores Softgel as described in claim any one of 1-2, which is characterized in that including following step
Suddenly：
It is spare as content feed liquid to weigh required ganoderma lucidum spore oil by formula for step 1；
Step 2 weighs glycerol, in purified water additionization glue tank by formula rate, and gelatin is added in heating, and stirring dissolves, and takes out true
Sky degassing, sieves with 100 mesh sieve, and glue is injected to keep the temperature in insulation barrel and is placed, and visual examination bubble-free, standby as capsule shells feed liquid
With；
Content feed liquid and capsule shells feed liquid are carried out pelleting operation by pelleting device by step 3；
Sizing is dried to the material completed after pelleting is processed in step 4；
Step 5 carries out the capsule after completion patterning process to wash ball processing；
Processing is dried in step 6, the capsule washed after ball processing to completion；
Step 7 carries out the capsule completed after drying is processed to pick ball operation, and then dress operation is wrapped inside to capsule；
Step 8 carries out outer packing operation in production clean area to the Packaging Bottle for completing inner packing, and then grasps to outer packing is completed
The capsule of work carries out warehousing finished products.
4. the preparation method of G. lucidum spores Softgel as claimed in claim 3, it is characterised in that：The mixing glycerol of step 2
The temperature of heating is 70 DEG C -80 DEG C.
5. the preparation method of G. lucidum spores Softgel as claimed in claim 3, it is characterised in that：The mixing glycerol of step 2
Vacuum outgas pressure be 0.06Mpa-0.08Mpa.
6. the preparation method of G. lucidum spores Softgel as claimed in claim 3, it is characterised in that：The mixing glycerol of step 2
Particle less than 150 microns.
7. the preparation method of G. lucidum spores Softgel as claimed in claim 3, it is characterised in that：The mixing glycerol of step 2
Insulation barrel in temperature be 55 DEG C -65 DEG C.
8. the preparation method of G. lucidum spores Softgel as claimed in claim 3, it is characterised in that：The pelleting that step 3 carries out
Operation is limited in 0.5g to the weight of pill.
9. the preparation method of G. lucidum spores Softgel as claimed in claim 3, it is characterised in that：Step 4 is dried fixed
At 18 DEG C -26 DEG C, relative humidity is controlled in 30%-40% for drying temperature control when type is processed.
10. the preparation method of G. lucidum spores Softgel as claimed in claim 3, it is characterised in that：To the capsule of step 6
The drying time of progress is -36 hours 24 hours, 24 DEG C -28 DEG C of dry temperature, relative humidity 20%-30%.
11. the preparation method of G. lucidum spores Softgel as claimed in claim 3, it is characterised in that：The bottling of step 7 is grasped
As 60/bottle, inner packing plastic bottle should meet《Oral stable medicinal polythene bottle with high density》(YBB00122002) standard
It is required that.
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| CN201810793574.7A CN108904550A (en) | 2018-07-19 | 2018-07-19 | A kind of G. lucidum spores Softgel and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109645530A (en) * | 2019-01-09 | 2019-04-19 | 安徽亳药千草国药股份有限公司 | It is a kind of for the encapsulating machine of Se-rich lucid ganoderma spore oil to be perfused |
| CN110663914A (en) * | 2019-10-28 | 2020-01-10 | 珠海经济特区天然药物研究所有限公司 | Food for assisting in regulating blood sugar and preparation method thereof |
| CN111686090A (en) * | 2020-06-17 | 2020-09-22 | 福建省神六保健食品有限公司 | Spirulina-ganoderma spore oil soft capsule and processing technology thereof |
| CN114533559A (en) * | 2022-04-12 | 2022-05-27 | 康道生物（南通）有限公司 | Method and equipment for preparing soft capsule |
| CN114601162A (en) * | 2022-03-22 | 2022-06-10 | 康道生物（南通）有限公司 | Method and equipment for preparing ganoderma lucidum spore oil lycopene self-emulsifying soft capsules |
| CN115251389A (en) * | 2022-06-23 | 2022-11-01 | 南昌蜂芝缘健康科技有限公司 | Ganoderma lucidum spore oil sea-buckthorn soft capsule and preparation method thereof |
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| CN104083409A (en) * | 2014-06-17 | 2014-10-08 | 湖北绿特欣生物科技股份有限公司 | Preparation method of Mythic Fungus spore oil and its softgel |
| CN105832778A (en) * | 2016-04-28 | 2016-08-10 | 上海春芝堂生物制品有限公司 | Ganoderma lucidum spore oil composite preparation and preparing method thereof |
| CN106490603A (en) * | 2016-11-08 | 2017-03-15 | 赵伟 | G. lucidum spores Softgel and preparation method thereof |
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2018
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Patent Citations (3)
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| CN104083409A (en) * | 2014-06-17 | 2014-10-08 | 湖北绿特欣生物科技股份有限公司 | Preparation method of Mythic Fungus spore oil and its softgel |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109645530A (en) * | 2019-01-09 | 2019-04-19 | 安徽亳药千草国药股份有限公司 | It is a kind of for the encapsulating machine of Se-rich lucid ganoderma spore oil to be perfused |
| CN110663914A (en) * | 2019-10-28 | 2020-01-10 | 珠海经济特区天然药物研究所有限公司 | Food for assisting in regulating blood sugar and preparation method thereof |
| CN111686090A (en) * | 2020-06-17 | 2020-09-22 | 福建省神六保健食品有限公司 | Spirulina-ganoderma spore oil soft capsule and processing technology thereof |
| CN114601162A (en) * | 2022-03-22 | 2022-06-10 | 康道生物（南通）有限公司 | Method and equipment for preparing ganoderma lucidum spore oil lycopene self-emulsifying soft capsules |
| CN114533559A (en) * | 2022-04-12 | 2022-05-27 | 康道生物（南通）有限公司 | Method and equipment for preparing soft capsule |
| CN115251389A (en) * | 2022-06-23 | 2022-11-01 | 南昌蜂芝缘健康科技有限公司 | Ganoderma lucidum spore oil sea-buckthorn soft capsule and preparation method thereof |
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Application publication date: 20181130 |