CN114527114A - Magnetic separation washs mixing equipment - Google Patents
Magnetic separation washs mixing equipment Download PDFInfo
- Publication number
- CN114527114A CN114527114A CN202210151205.4A CN202210151205A CN114527114A CN 114527114 A CN114527114 A CN 114527114A CN 202210151205 A CN202210151205 A CN 202210151205A CN 114527114 A CN114527114 A CN 114527114A
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- China
- Prior art keywords
- waste liquid
- magnet
- liquid needle
- magnetic separation
- mounting seat
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/28—Moving reactors, e.g. rotary drums
- B01J19/285—Shaking or vibrating reactors; reactions under the influence of low-frequency vibrations or pulsations
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B08—CLEANING
- B08B—CLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
- B08B13/00—Accessories or details of general applicability for machines or apparatus for cleaning
Abstract
The invention relates to magnetic separation cleaning and uniformly mixing equipment which comprises a magnetic separation disc assembly, wherein the magnetic separation disc assembly comprises a first magnet mounting position and a second magnet mounting position which are opposite in position, magnets are arranged on the first magnet mounting position and the second magnet mounting position respectively, a reaction cup processing position is formed between the first magnet mounting position and the second magnet mounting position, and the reaction cup and the magnets generate magnetic attraction after entering the reaction cup processing position. The invention has novel conception and unique effect, can improve the adsorption effect by adopting double-sided adsorption, further improves the stability of adsorption and the stability of a loss rate measurement result, avoids adverse effects caused by magnetization by adopting a non-magnetic material to prepare the waste liquid needle, has good effect by arranging the blending device to correspond to the blending treatment of the reaction cup, and provides an adjustable structure aiming at the arrangement of the waste liquid needle so as to realize the adjustment of the installation position of the waste liquid needle.
Description
Technical Field
The invention relates to the technical field of medical equipment, in particular to magnetic separation cleaning and uniformly mixing equipment.
Background
At present, a magnetic separation, cleaning and uniformly mixing device is often used on a chemiluminescence immunoassay analyzer.
The magnetic particle composite is a carrier for the effective luminescence signal to be measured.
Magnetic separation is a technique for separating such an effective signal carrier to be measured from other reaction liquids.
The main magnetic separation method at present is a magnetic bead adsorption cleaning separation mode. In the process of cleaning and separating, the reaction liquid is often required to be fully mixed, so that a better cleaning effect is achieved, and accurate test data is obtained.
The existing magnetic separation cleaning and mixing device has the following defects:
1. in a magnetic field adsorption mode, most instruments use a single-side adsorption mode, and although the magnetic bead adsorption function is also realized, the adsorption stability and the loss rate are unstable;
2. a cleaning and blending mode is adopted, a blending linkage mode is frequently adopted, but errors in processing, manufacturing and assembling may exist in the same instrument, so that the blending rotating speed at a single position cannot be adjusted;
3. 316L or 304 stainless steel needles are adopted in most instruments, the treated stainless steel can reach weak magnetism, but the magnetism is reversible, and certain magnetism can be recovered during subsequent use, so that great influence and obstruction are generated on magnetic adsorption;
4. the whole process of magnetic separation cleaning and uniform mixing has relatively high processing and manufacturing requirements, and has simple, adjustable and stable assembly structure for ensuring consistency and stability aiming at the arrangement of the waste liquid needle.
Disclosure of Invention
In view of the problems of insufficient stability and inaccurate loss rate confirmation in the adsorption process caused by the fact that most of the single-side adsorption modes are used together, the invention provides magnetic separation, cleaning and uniform mixing equipment to design a double-side adsorption structure, so that the stability in the adsorption process is higher, the loss rate is more accurately measured, and the loss rate is smaller.
The invention is realized by the following technical scheme:
the utility model provides a magnetic separation washs mixing equipment, includes the magnetic separation dish subassembly, the magnetic separation dish subassembly includes that the relative first magnet of position is settled the position and the position is settled to second magnet, first magnet is settled the position and is all provided with magnet with the position is settled to second magnet, first magnet is settled and is set and second magnet and settle and form reaction cup processing position between the position, and reaction cup gets into behind the reaction cup processing position with magnet produces magnetism and inhales the effect.
By adopting the technical scheme, the magnetic separation disc assembly is used for carrying out magnetic separation treatment on substances in the reaction cup.
The first magnet mounting position and the second magnet mounting position are used for oppositely arranging two magnets, and a magnetic field is formed through the magnets, so that double-sided adsorption is formed to adsorb substances in the reaction cup.
The reaction cup processing position is used for reaction cup entering. When the reaction cup enters the reaction cup processing position, the adsorption reaction is further conveniently generated under the action of the magnetic field.
In this scheme, adopt two-sided absorption, can promote adsorption effect, and then promote the stability of absorbent stability and loss rate testing result.
In some embodiments, the number of the first magnet installation positions and the second magnet installation positions is plural.
In the preferred embodiment, a plurality of first magnet mounting positions and second magnet mounting positions are provided, and magnets are incorporated to form a magnetic field and further to accommodate the treatment of a plurality of cuvettes.
In some embodiments, the magnetic separation disc assembly includes a first magnet mount and a second magnet mount, the first magnet mounting location being disposed on the first magnet mount, and the second magnet mounting location being disposed on the second magnet mount.
In the preferred embodiment, two magnet mounting seats are provided to respectively correspond to the first magnet mounting position and the second magnet mounting position, so that a stable installation structure can be formed.
In some embodiments, the reaction cup further comprises a waste liquid needle for extracting waste liquid from the reaction cup, and the waste liquid needle is made of nonmagnetic materials.
Based on the adoption of 316L or 304 stainless steel needles in most instruments, the treated stainless steel can reach weak magnetism, but the magnetism is reversible, and certain magnetism can be recovered during subsequent use, so that the defects of larger influence and obstruction on magnetic adsorption are generated. In the preferred embodiment, a non-magnetic material is used.
In some embodiments, the waste needle is made of non-magnetic steel or/and titanium alloy.
In the preferred embodiment, materials are specifically provided that are suitable for use in the manufacture of waste needles having non-magnetic properties.
In some embodiments, the mixing device further comprises a mixing mechanism for shaking the reaction cups to achieve mixing, wherein the mixing mechanism corresponds to the reaction cup processing position, and the mixing mechanism comprises a connecting piece for connecting to the reaction cups and a power device for outputting mixing.
The blending linkage mode is frequently used, but because the same instrument possibly has errors of processing, manufacturing and assembling, the blending rotating speed at a single position cannot be adjusted. In the preferred embodiment, a kneading device corresponding to the processing position of the cuvette is provided.
The power device of the blending device is used for providing power, and the connecting piece is used for being connected to the reaction cup. The power device outputs power to the connecting piece.
In some embodiments, the power device is a motor, and an output end of the motor is connected with an eccentric shaft, and the connecting piece is arranged outside the eccentric shaft.
In the preferred embodiment, a specific form of the blending device is given, namely, the power is output by a motor, and the shaking is realized by arranging an eccentric rotation mode.
In some embodiments, the connector is a tubular member for receiving a reaction cup.
In the preferred embodiment, a structural form of the connecting piece is specifically given.
In some embodiments, the reaction cup further comprises a waste liquid needle for extracting waste liquid from the reaction cup and a waste liquid needle arm for arranging the waste liquid needle, wherein a waste liquid needle mounting seat is arranged on the waste liquid needle arm, the waste liquid needle is arranged on the waste liquid needle mounting seat, and the waste liquid needle mounting seat is connected to the waste liquid needle arm in a position-adjustable manner.
Based on the whole flow of magnetic separation washing mixing, manufacturing requires relatively higher, to the setting of waste liquid needle, has the simple problem that the stable assembly structure of adjustable does benefit to the assurance of uniformity stability. In the preferred embodiment, a waste liquid needle setting structure is provided, that is, a waste liquid needle is set through the waste liquid needle mounting seat. The position of the waste liquid needle mounting seat is adjustable, so that the waste liquid needle can change relative to the position of the waste liquid needle arm.
In some embodiments, the waste needle arm is provided with two first bolt holes, the waste needle mounting seat is provided with two second bolt holes, the two second bolt holes correspond to the two first bolt holes, the diameter of each second bolt hole is larger than that of each first bolt hole, the first bolt holes and the second bolt holes are connected through bolts, so that the waste needle arm and the waste needle mounting seat are connected, and the waste needle mounting seat is connected to the waste needle arm through bolt fastening.
In the preferred embodiment, a connection structure form of the waste liquid needle arm and the waste liquid needle mounting seat is provided. Bolted connection realizes fixed the setting in first bolt hole, because second bolt hole aperture is bigger, then can realize that waste liquid needle mount pad is adjustable for the position of waste liquid needle arm. After the waste liquid needle mounting seat is adjusted in place, the bolt presses the waste liquid needle mounting seat to be fixed to the waste liquid needle arm through the fastening bolt.
Compared with the prior art, the invention has the following advantages and beneficial effects:
the invention has novel conception and unique effect, can improve the adsorption effect by adopting double-sided adsorption, further improves the stability of adsorption and the stability of a loss rate measurement result, avoids adverse effects caused by magnetization by adopting a non-magnetic material to prepare the waste liquid needle, has good effect by arranging the blending device to correspond to the blending treatment of the reaction cup, and provides an adjustable structure aiming at the arrangement of the waste liquid needle so as to realize the adjustment of the installation position of the waste liquid needle.
Drawings
In order to more clearly illustrate the technical solutions of the exemplary embodiments of the present invention, the drawings that are required to be used in the embodiments will be briefly described below, it should be understood that the following drawings only illustrate some embodiments of the present invention and therefore should not be considered as limiting the scope, and that for those skilled in the art, other related drawings can be obtained from these drawings without inventive effort. In the drawings:
FIG. 1 is a schematic structural diagram according to an embodiment of the present invention;
FIG. 2 is a schematic structural diagram of a side view in an embodiment of the present invention;
fig. 3 is a schematic view of an arrangement structure of a magnet mounting position and a mounting seat according to an embodiment of the present invention.
FIG. 4 is a schematic diagram of the blending mechanism of the embodiment of the present invention, showing the structure of the connecting member;
fig. 5 is a blending mechanism in an embodiment of the invention, and shows a schematic structural diagram of an eccentric shaft.
Reference numbers and corresponding part names in the drawings:
a frame-100;
liquid adding needle-200;
waste needle arm-300;
a magnetic separation disc assembly-400, a first magnet mounting seat-410, a second magnet mounting seat-420, a disc shell-430, a first fixing plate-440, a second fixing plate-450 and a third fixing plate-460;
waste liquid needle-500;
a blending mechanism-600, a connecting piece-610, a power device-620 and an eccentric shaft-630;
a waste liquid needle mounting seat-700;
liquid adding needle cantilever-800.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to examples and accompanying drawings, and the exemplary embodiments and descriptions thereof are only used for explaining the present invention and are not meant to limit the present invention.
Referring to fig. 1-5, a magnetic separation, cleaning and blending apparatus includes a frame 100, a liquid feeding needle 200, a magnetic separation disc assembly 400, a waste liquid needle 500, and a blending mechanism 600.
The frame 100 is used for arranging the liquid adding needle 200, the magnetic separation disc assembly 400, the waste liquid needle 500 and the blending mechanism 600.
The magnetic separation disc assembly 400 is disposed at the middle of the rack 100.
The liquid feeding needle 200 and the waste liquid needle 500 are disposed at an upper portion of the frame 100, and the liquid feeding needle 200 and the waste liquid needle 500 are also disposed above the magnetic separation disk assembly 400.
The kneading mechanism 600 is provided at the lower portion of the frame 100.
Filling needle 200 is positioned on corresponding filling needle cantilever 800. The waste needle 500 is provided to the waste needle arm 300. Filling needle arm 800 and waste needle arm 300 are then attached to frame 100.
To achieve vertical movement of fill needle 200 and waste needle 500, fill needle cantilever 800 and waste needle arm 300 are each connected to frame 100 by a linear rail mechanism.
To avoid adverse effects of magnetization, in some embodiments, the waste needle 500 is made of a non-magnetic material.
Further, to provide a specific non-magnetic material, in some embodiments, the waste needle 500 is made of non-magnetic steel or/and titanium alloy. In specific implementation, the material can also be made of other nonmagnetic materials, including metal materials, inorganic materials, organic polymer materials and the like.
The magnetic separation disk assembly 400 is used to magnetically attract the substances in the reaction cup.
In order to realize the effect of two-sided magnetism, magnetic separation dish subassembly 400 is used for magnetic separation dish subassembly 400 includes that the relative first magnet in position is installed position A and second magnet and is installed position B, first magnet is installed position A and second magnet and is installed position B and all be provided with magnet.
In this scheme, adopt two-sided absorption, can promote adsorption effect, and then promote the stability of absorbent stability and loss rate testing result.
A reaction cup processing position C is formed between the first magnet mounting position A and the second magnet mounting position B, and the reaction cup enters the reaction cup processing position C and then generates magnetic attraction with the magnet.
The first magnet mounting position A and the second magnet mounting position B are both non-physical. Thus, in some embodiments, the magnetic separation disc assembly 400 includes a first magnet mount 410 and a second magnet mount 420.
The first magnet installation position a is disposed on the first magnet installation seat 410.
The second magnet installation site B is disposed on the second magnet installation seat 420.
The first magnet mounting position A and the second magnet mounting position B are used for oppositely arranging two magnets, and a magnetic field is formed by the magnets, so that double-sided adsorption is formed to adsorb substances in the reaction cup.
The reaction cup processing position C is used for reaction cup entering. When the reaction cup enters the reaction cup processing position C, the adsorption reaction is further conveniently generated under the action of a magnetic field.
In this scheme, adopt two-sided absorption, can promote adsorption effect, and then promote the stability of absorbent stability and loss rate testing result.
In order to achieve uniform mixing of the substances in the reaction cups, in some embodiments, the mixing device further comprises a mixing mechanism 600 for shaking the reaction cups to achieve uniform mixing, and the mixing mechanism 600 corresponds to the reaction cup processing position C.
The mixing mechanism 600 comprises a connecting piece 610 for connecting to a reaction cup and a power device 620 for outputting mixing.
The blending linkage mode is frequently used, but because the same instrument possibly has errors of processing, manufacturing and assembling, the blending rotating speed at a single position cannot be adjusted. In the preferred embodiment, a kneading device 600 corresponding to the processing position of the cuvette is provided.
Further, in some embodiments, the power device 620 is a motor, and an output end of the motor is connected with an eccentric shaft 630, and the connecting member 610 is mounted outside the eccentric shaft 630.
In some embodiments, the connector 610 is a tubular member for receiving a reaction cup.
The waste liquid needle 500 is used to draw waste liquid from the reaction cup.
In some embodiments, the waste needle arm 300 is provided with a waste needle mount 700.
The waste needle 500 is installed in the waste needle installation seat 700, and the waste needle installation seat 700 is adjustably connected to the waste needle arm 300.
Further, in some embodiments, a specific adjustable connection manner is provided, two first bolt holes are provided on the waste needle arm 300, two second bolt holes are provided on the waste needle mounting seat 700, two second bolt holes correspond to two first bolt holes, the aperture of the second bolt hole is larger than that of the first bolt hole, the first bolt hole and the second bolt hole are connected through a bolt, so as to realize the connection between the waste needle arm 300 and the waste needle mounting seat 700, and the waste needle mounting seat 700 is connected to the waste needle arm 300 through a bolt fastening.
This preference provides a form of connection structure for waste needle arm 300 and waste needle mount 700. Bolted connection realizes fixed setting in first bolt hole, because second bolt hole aperture is bigger, then can realize waste liquid needle mount pad 700 for waste liquid needle arm 300's adjustable position. After the adjustment is in place, the bolts press the waste liquid needle mounting base 700 to be fixed to the waste liquid needle arm 300 by tightening the bolts.
In some embodiments, the number of the waste needles 500 is plural in order to accommodate a plurality of reaction cups. As shown in fig. 1 and 2, in one embodiment, the number of the waste needles 500 is four.
In some embodiments, in order to accommodate a plurality of reaction cups, the number of the liquid adding needles 200 is plural, as shown in fig. 1 and 2, and in one embodiment, the number of the liquid adding needles 200 is five.
In some embodiments, the magnetic separation disk assembly 400 includes a disk housing 430 for stable placement of the reaction cup. A first fixing plate 440, a second fixing plate 450 and a third fixing plate 460 for fixing a reaction cup are disposed in the tray case 430.
The first fixing plate 440, the second fixing plate 450 and the third fixing plate 460 are all provided with holes for inserting reaction cups.
In some embodiments, in order to accommodate a plurality of reaction cups, a plurality of holes are formed on each of the first, second and third fixing plates 440, 450 and 460.
In some embodiments, the mixing mechanism 600 is provided in a plurality in order to accommodate a plurality of reaction cups.
In some embodiments, the first magnet mount 410 and the second magnet mount 420 are divided into a plurality of groups, each group including a single body of the first magnet mount 410 and a single body of the first second magnet mount 420.
The single body of the first magnet mounting seat 410 and the single body of the second magnet mounting seat 420 are both arc-shaped and are arranged side by side in the radial direction.
The plurality of groups of the monomers are arranged into a circular whole.
Further, in some embodiments, the connecting member 610 extends into the space between two adjacent monomers, so that the reaction cups are directly connected by the connecting member 610 when moving, thereby realizing shaking.
Through the basic scheme and the preferred embodiments, the waste liquid needle adsorption device has the advantages that the conception is novel, the effect is unique, the adsorption effect can be improved by adopting double-sided adsorption, the stability of adsorption and the stability of a loss rate measurement result are further improved, the waste liquid needle is made of a non-magnetic material, the adverse effect caused by magnetization is avoided, the mixing device is arranged to correspond to the mixing treatment of the reaction cup, the effect is good, and an adjustable structure is provided for the arrangement of the waste liquid needle, so that the adjustment of the installation position of the waste liquid needle is realized.
The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are merely exemplary embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.
Claims (10)
1. The utility model provides a magnetic separation washs mixing equipment, includes magnetic separation dish subassembly (400), its characterized in that, magnetic separation dish subassembly (400) are including the relative first magnet of position and are installed position (A) and second magnet and install position (B), first magnet is installed position (A) and second magnet and is installed position (B) and all be provided with magnet, first magnet is installed and is formed reaction cup between position (A) and the second magnet is installed and handle position (C), and the reaction cup gets into behind reaction cup handle position (C) with magnet produces the magnetic attraction effect.
2. The magnetic separation, cleaning and blending device according to claim 1, wherein the number of the first magnet mounting positions (A) and the number of the second magnet mounting positions (B) are multiple.
3. The magnetic separation cleaning and mixing device according to claim 1 or 2, wherein the magnetic separation disc assembly (400) comprises a first magnet mounting seat (410) and a second magnet mounting seat (420), the first magnet mounting seat (A) is arranged on the first magnet mounting seat (410), and the second magnet mounting seat (B) is arranged on the second magnet mounting seat (420).
4. The magnetic separation, cleaning and blending device of claim 1, further comprising a waste liquid needle (500) for extracting waste liquid from the reaction cup, wherein the waste liquid needle (500) is made of a non-magnetic material.
5. The magnetic separation, cleaning and blending device according to claim 4, wherein the waste liquid needle (500) is made of non-magnetic steel or/and titanium alloy.
6. The magnetic separation cleaning blending device according to claim 1, further comprising a blending mechanism (600) for shaking the reaction cups to achieve blending, wherein the blending mechanism (600) corresponds to the reaction cup processing position (C), and the blending mechanism (600) comprises a connecting piece (610) for connecting to the reaction cups and a power device (620) for outputting blending.
7. The magnetic separation, cleaning and blending device according to claim 6, wherein the power device (620) is a motor, an output end of the motor is connected with an eccentric shaft (630), and the connecting piece (610) is arranged outside the eccentric shaft (630).
8. The magnetic separation, cleaning and blending device of claim 7, wherein the connector (610) is a tubular member for receiving a reaction cup.
9. The magnetic separation, cleaning and blending device according to claim 1, further comprising a waste liquid needle (500) for extracting waste liquid from the reaction cup and a waste liquid needle arm (300) for arranging the waste liquid needle (500), wherein a waste liquid needle mounting seat (700) is arranged on the waste liquid needle arm (300), the waste liquid needle (500) is arranged on the waste liquid needle mounting seat (700), and the waste liquid needle mounting seat (700) is connected to the waste liquid needle arm (300) in a position-adjustable manner.
10. The magnetic separation cleaning and mixing device according to claim 9, wherein the waste liquid needle arm (300) is provided with two first bolt holes, the waste liquid needle mounting seat (700) is provided with two second bolt holes, the two second bolt holes correspond to the two first bolt holes, the diameter of each second bolt hole is larger than that of each first bolt hole, the first bolt holes and the second bolt holes are connected through bolts to realize the connection between the waste liquid needle arm (300) and the waste liquid needle mounting seat (700), and the waste liquid needle mounting seat (700) is connected to the waste liquid needle arm (300) through bolt fastening.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210151205.4A CN114527114A (en) | 2022-02-15 | 2022-02-15 | Magnetic separation washs mixing equipment |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210151205.4A CN114527114A (en) | 2022-02-15 | 2022-02-15 | Magnetic separation washs mixing equipment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114527114A true CN114527114A (en) | 2022-05-24 |
Family
ID=81622923
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210151205.4A Pending CN114527114A (en) | 2022-02-15 | 2022-02-15 | Magnetic separation washs mixing equipment |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114527114A (en) |
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2022
- 2022-02-15 CN CN202210151205.4A patent/CN114527114A/en active Pending
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