CN114504605A - Medicament-silicon dioxide composite antibacterial liquid and preparation method thereof - Google Patents
Medicament-silicon dioxide composite antibacterial liquid and preparation method thereof Download PDFInfo
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- CN114504605A CN114504605A CN202210130107.2A CN202210130107A CN114504605A CN 114504605 A CN114504605 A CN 114504605A CN 202210130107 A CN202210130107 A CN 202210130107A CN 114504605 A CN114504605 A CN 114504605A
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- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 title claims abstract description 169
- 239000007788 liquid Substances 0.000 title claims abstract description 150
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 87
- 239000000377 silicon dioxide Substances 0.000 title claims abstract description 84
- 239000002131 composite material Substances 0.000 title claims abstract description 74
- 238000002360 preparation method Methods 0.000 title claims abstract description 47
- 239000006185 dispersion Substances 0.000 claims abstract description 101
- 235000012239 silicon dioxide Nutrition 0.000 claims abstract description 46
- 239000005543 nano-size silicon particle Substances 0.000 claims abstract description 45
- 238000003756 stirring Methods 0.000 claims abstract description 35
- 239000002253 acid Substances 0.000 claims abstract description 29
- 239000003814 drug Substances 0.000 claims abstract description 29
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 23
- 238000002156 mixing Methods 0.000 claims abstract description 20
- BLUAFEHZUWYNDE-NNWCWBAJSA-N artemisinin Chemical compound C([C@](OO1)(C)O2)C[C@H]3[C@H](C)CC[C@@H]4[C@@]31[C@@H]2OC(=O)[C@@H]4C BLUAFEHZUWYNDE-NNWCWBAJSA-N 0.000 claims abstract description 19
- 229960004191 artemisinin Drugs 0.000 claims abstract description 19
- 229930101531 artemisinin Natural products 0.000 claims abstract description 19
- 241000037740 Coptis chinensis Species 0.000 claims abstract description 11
- 244000303040 Glycyrrhiza glabra Species 0.000 claims abstract description 11
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 claims abstract description 11
- 240000000691 Houttuynia cordata Species 0.000 claims abstract description 11
- 240000004534 Scutellaria baicalensis Species 0.000 claims abstract description 10
- 235000017089 Scutellaria baicalensis Nutrition 0.000 claims abstract description 10
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 10
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims abstract description 10
- 229930182490 saponin Natural products 0.000 claims abstract description 10
- 235000017709 saponins Nutrition 0.000 claims abstract description 10
- 150000007949 saponins Chemical class 0.000 claims abstract description 10
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims abstract description 9
- 235000011477 liquorice Nutrition 0.000 claims abstract description 9
- 240000001949 Taraxacum officinale Species 0.000 claims abstract 2
- 238000009210 therapy by ultrasound Methods 0.000 claims description 35
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 30
- 239000002245 particle Substances 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 9
- 241000746375 Andrographis Species 0.000 claims description 8
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 claims description 8
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 claims description 6
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 claims description 6
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 229910000147 aluminium phosphate Inorganic materials 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- QWPPOHNGKGFGJK-UHFFFAOYSA-N hypochlorous acid Chemical compound ClO QWPPOHNGKGFGJK-UHFFFAOYSA-N 0.000 claims description 3
- 241000758794 Asarum Species 0.000 claims description 2
- 235000013717 Houttuynia Nutrition 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 206010059866 Drug resistance Diseases 0.000 abstract description 10
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- 241000411851 herbal medicine Species 0.000 abstract description 8
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- 239000002085 irritant Substances 0.000 abstract description 5
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- 231100000331 toxic Toxicity 0.000 abstract description 5
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- 244000118350 Andrographis paniculata Species 0.000 abstract description 2
- 238000005303 weighing Methods 0.000 description 24
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- 229910021641 deionized water Inorganic materials 0.000 description 17
- 239000000203 mixture Substances 0.000 description 16
- 230000000052 comparative effect Effects 0.000 description 11
- 239000003242 anti bacterial agent Substances 0.000 description 10
- 241000245665 Taraxacum Species 0.000 description 8
- 239000008177 pharmaceutical agent Substances 0.000 description 8
- 238000000527 sonication Methods 0.000 description 5
- 230000001580 bacterial effect Effects 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 2
- 235000001453 Glycyrrhiza echinata Nutrition 0.000 description 2
- 235000017382 Glycyrrhiza lepidota Nutrition 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 229940088710 antibiotic agent Drugs 0.000 description 2
- 229940010454 licorice Drugs 0.000 description 2
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
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- 230000004048 modification Effects 0.000 description 1
- 239000008342 pharmaceutical dispersion Substances 0.000 description 1
- 150000003242 quaternary ammonium salts Chemical class 0.000 description 1
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
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Abstract
The invention relates to a medicament-silicon dioxide composite antibacterial liquid and a preparation method thereof. The preparation method comprises the following steps: dispersing a medicament in an acid solution to obtain a first dispersion liquid, wherein the pH value of the acid solution is 3-5, and the medicament is at least one selected from artemisinin, folium artemisiae argyi, coptis chinensis, andrographis paniculata, houttuynia cordata, liquorice, saponin, scutellaria baicalensis and dandelion; dispersing nano silicon dioxide in water to obtain a second dispersion liquid; and stirring and mixing the first dispersion liquid and the second dispersion liquid to obtain the medicament-silicon dioxide composite antibacterial liquid. The nano silicon dioxide is used as a nano antibacterial material, has the characteristics of stronger transmembrane capacity, function of inhibiting discharge, difficulty in inducing drug resistance of bacteria and the like, is prepared from natural Chinese herbal medicines, has good antibacterial effect, relatively small adverse reaction and difficulty in occurrence of drug resistance, and ensures that the composite antibacterial liquid not only has the functions of resisting bacteria and fungi, but also has the functions of resisting virus and diminishing inflammation, and the composite antibacterial liquid is mild, non-irritant, safe and free of toxic and side effects.
Description
Technical Field
The invention relates to the technical field of antibiosis, in particular to a medicament-silicon dioxide composite antibacterial liquid and a preparation method thereof.
Background
Conventional antibacterial materials such as antibiotics, quaternary ammonium salts, etc. cause resistance to microorganisms. In recent years, the problem of bacterial resistance has become more serious as a result of abuse of antibiotics. Therefore, the search for efficient, safe and drug-resistant antibacterial materials is urgent.
Disclosure of Invention
Accordingly, there is a need for an efficient, safe, and drug-resistant silica composite antibacterial solution and a method for preparing the same.
One of the purposes of the invention is to provide a preparation method of a medicament-silicon dioxide composite antibacterial liquid, which comprises the following steps:
the preparation method of the medicament-silicon dioxide composite antibacterial liquid is characterized by comprising the following steps of:
dispersing a medicament in an acid solution to obtain a first dispersion liquid, wherein the pH value of the acid solution is 3-5, and the medicament is at least one selected from artemisinin, folium artemisiae argyi, coptis chinensis, common andrographis herb, heartleaf houttuynia herb, liquorice, saponin, scutellaria baicalensis and dandelion;
dispersing nano silicon dioxide in water to obtain a second dispersion liquid;
and stirring and mixing the first dispersion liquid and the second dispersion liquid to obtain the medicament-silicon dioxide composite antibacterial liquid.
In one embodiment, the acid solution is selected from at least one of carbonic acid, silicic acid, hypochlorous acid, acetic acid, and phosphoric acid.
In one embodiment, the sonication is performed during the dispersion of the agent in the acid solution.
In one embodiment, the power of ultrasonic treatment is 200W-400W, and the frequency is 30 KHz-50 KHz.
In one embodiment, the first dispersion and the second dispersion are stirred and mixed for 3 to 6 hours.
In one embodiment, the concentration of the pharmaceutical agent in the first dispersion is 0.01mg/mL to 0.03 mg/mL.
In one embodiment, the concentration of the second dispersion is 0.25mg/mL to 0.75 mg/mL.
In one embodiment, the nano-silica has a particle size of 30nm to 60 nm.
In one embodiment, the mass ratio of the pharmaceutical agent to the nanosilica is 1: 1-1: 7.
In one embodiment, the mass ratio of the pharmaceutical agent to the nanosilica is 1: 2-1: 6.
The invention also aims to provide a medicament-silicon dioxide composite antibacterial liquid, which adopts the following scheme:
a medicament-silicon dioxide composite antibacterial liquid, which is prepared by the preparation method of any one of the embodiments.
Compared with the existing scheme, the medicament-silicon dioxide composite antibacterial liquid and the preparation method thereof have the following beneficial effects:
according to the medicament-silicon dioxide composite antibacterial liquid and the preparation method thereof, the first dispersion liquid containing the medicament and the second dispersion liquid containing the nano-silicon dioxide are stirred and mixed to obtain a composite product of the organic antibacterial agent and the inorganic antibacterial agent, and the antibacterial capability is more comprehensive and efficient. The nano silicon dioxide is used as a nano antibacterial material, has the characteristics of stronger transmembrane capacity, function of inhibiting discharge, difficulty in inducing bacterial drug resistance and the like, the medicament is selected from at least one of artemisinin, folium artemisiae argyi, coptis chinensis, common andrographis herb, houttuynia cordata, liquorice, saponin, scutellaria baicalensis and dandelion, the medicament is obtained from natural Chinese herbal medicines, the natural Chinese herbal medicines have good antibacterial action, relatively small adverse reaction and difficulty in generating drug resistance, the medicament enables the composite antibacterial liquid to have the functions of resisting bacteria and fungi and also has the functions of resisting viruses and diminishing inflammation, and the medicament-silicon dioxide composite antibacterial liquid prepared by the method is mild, non-irritant, safe and free of toxic and side effects.
Drawings
FIG. 1 is a photograph of the drug-silica composite antibacterial solution prepared in example 1.
Detailed Description
To facilitate an understanding of the invention, the invention will now be described more fully with reference to the accompanying drawings. Preferred embodiments of the present invention are shown in the drawings. This invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. Rather, these embodiments are provided so that this disclosure will be thorough and complete.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items.
The preparation method of the medicament-silicon dioxide composite antibacterial liquid provided by the embodiment of the invention comprises the following steps:
step one, dispersing a medicament into an acid solution to obtain a first dispersion liquid, wherein the pH value of the acid solution is 3-5, and the medicament is selected from at least one of artemisinin, folium artemisiae argyi, coptis chinensis, common andrographis herb, houttuynia cordata, liquorice, saponin, scutellaria baicalensis and dandelion.
And step two, dispersing the nano silicon dioxide in water to obtain a second dispersion liquid.
And step three, stirring and mixing the first dispersion liquid and the second dispersion liquid to obtain the medicament-silicon dioxide composite antibacterial liquid.
According to the preparation method of the medicament-silicon dioxide composite antibacterial liquid, the first dispersion liquid containing the medicament and the second dispersion liquid containing the nano-silicon dioxide are stirred and mixed to obtain a composite product of the organic antibacterial agent and the inorganic antibacterial agent, and the antibacterial capability is more comprehensive. The nano silicon dioxide is used as a nano antibacterial material, has the characteristics of stronger transmembrane capacity, function of inhibiting discharge, difficulty in inducing bacterial drug resistance and the like, the medicament is selected from at least one of artemisinin, folium artemisiae argyi, coptis chinensis, common andrographis herb, houttuynia cordata, liquorice, saponin, scutellaria baicalensis and dandelion, the medicament is obtained from natural Chinese herbal medicines, the natural Chinese herbal medicines have good antibacterial action, relatively small adverse reaction and difficulty in generating drug resistance, the medicament enables the composite antibacterial liquid to have the functions of resisting bacteria and fungi and also has the functions of resisting viruses and diminishing inflammation, and the medicament-silicon dioxide composite antibacterial liquid prepared by the method is mild, non-irritant, safe and free of toxic and side effects.
Wherein the folium artemisiae argyi, the coptis chinensis, the common andrographis herb, the houttuynia cordata, the scutellaria baicalensis and the dandelion are leachate used after being soaked in water for 5-8 hours at 54-56 ℃ (such as 55 ℃), and the mass ratio of the medicinal materials to the water is 2: 1-4: 1. The artemisinin, the liquorice and the saponin can be directly used.
It is understood that the first step and the second step may be to perform the first step and then perform the second step, or to perform the first step and then perform the second step.
Alternatively, the acid solution may be selected from, but not limited to, at least one of carbonic acid, silicic acid, hypochlorous acid, acetic acid, and phosphoric acid.
In one example, sonication is performed during the dispersion of the pharmaceutical agent in the acid solution. The agent is better dispersed in the acid solution by ultrasonic treatment.
In one example, the ultrasonic treatment power is 200W-400W, and the frequency is 30 KHz-50 KHz. In some specific examples, the power of the sonication is 200W, 250W, 300W, 350W, 400W, etc. In some specific examples, the frequency of the sonication is 30KHz, 35KHz, 40KHz, 45KHz, 50KHz, etc.
In one example, the first dispersion and the second dispersion are stirred and mixed for 3 to 6 hours. In some specific examples, the first dispersion and the second dispersion are mixed with stirring for 3 hours, 3.5 hours, 4 hours, 4.5 hours, 5 hours, and the like.
In one example, the concentration of the pharmaceutical agent in the first dispersion is 0.01mg/mL to 0.03 mg/mL. In some specific examples, the concentration of the pharmaceutical agent in the first dispersion is 0.01mg/mL, 0.015mg/mL, 0.02mg/mL, 0.025mg/mL, 0.03mg/mL, or the like.
In one example, the concentration of the second dispersion is 0.25mg/mL to 0.75 mg/mL. In some specific examples, the concentration of the second dispersion is 0.3mg/mL, 0.4mg/mL, 0.5mg/mL, 0.6mg/mL, 0.7mg/mL, and the like.
In one example, the nano-silica has a particle size of 30nm to 60 nm.
In one example, the mass ratio of the pharmaceutical agent to the nanosilica is 1: 1-1: 7. Further, in one example, the mass ratio of the pharmaceutical agent to the nanosilica is 1: 2-1: 6. In some specific examples, the mass ratio of the agent to the nanosilica is 1: 2, 1: 3, 1: 4, 1: 5, 1: 6, etc.
The invention also provides a medicament-silicon dioxide composite antibacterial liquid which is prepared by any one of the preparation methods.
The medicament-silicon dioxide composite antibacterial liquid is prepared by stirring and mixing the first dispersion liquid containing the medicament and the second dispersion liquid containing the nano-silicon dioxide, so that a composite product of the organic antibacterial agent and the inorganic antibacterial agent is obtained, and the antibacterial capability is more comprehensive. The nano silicon dioxide is used as a nano antibacterial material, has the characteristics of stronger transmembrane capacity, function of inhibiting discharge, difficulty in inducing bacterial drug resistance and the like, the medicament is selected from at least one of artemisinin, folium artemisiae argyi, coptis chinensis, common andrographis herb, houttuynia cordata, liquorice, saponin, scutellaria baicalensis and dandelion, is obtained from natural Chinese herbal medicines, has a good antibacterial effect, relatively small adverse reaction and difficulty in occurrence of drug resistance, and the medicament enables the composite antibacterial liquid to have the functions of resisting bacteria and fungi and also has the functions of resisting viruses and diminishing inflammation, and the medicament-silicon dioxide composite antibacterial liquid is mild, non-irritant, safe and free of toxic and side effects.
The following examples are provided to further illustrate the present invention, but the present invention is not limited to the following examples, and it should be understood that the scope of the present invention is summarized by the appended claims, and a person skilled in the art should realize that certain changes made to the embodiments of the present invention, in light of the inventive concept, are intended to be covered by the spirit and scope of the claims of the present invention.
Example 1
The embodiment provides a medicament-silicon dioxide composite antibacterial liquid and a preparation method thereof.
The preparation method of this example includes the following steps:
step 1, weighing 0.02mg of artemisinin and adding the artemisinin into 2mL of acetic acid solution, wherein the pH value of the acid solution is 4, and simultaneously carrying out ultrasonic treatment. The power of the ultrasonic instrument is 250W, the frequency is 40KHz, and the ultrasonic treatment is carried out for 5min, so as to obtain a first dispersion liquid.
And 2, weighing 0.02g of nano silicon dioxide, adding the nano silicon dioxide into 40mL of deionized water, and stirring the mixture for 25min at the rotating speed of 650rpm under the action of a magnetic stirrer to obtain a second dispersion liquid. Wherein the particle size of the nano-silica is about 50 nm.
And 3, stirring and mixing the first dispersion liquid and the second dispersion liquid for 3 hours under a magnetic stirrer to obtain the medicament-silicon dioxide composite antibacterial liquid.
Example 2
The embodiment provides a medicament-silicon dioxide composite antibacterial liquid and a preparation method thereof.
The preparation method of this example includes the following steps:
step 1, weighing 0.03mg of artemisinin and adding the artemisinin into 2mL of acetic acid solution, wherein the pH value of the acid solution is 4, and simultaneously carrying out ultrasonic treatment. The power of the ultrasonic instrument is 250W, the frequency is 40KHz, and the ultrasonic treatment is carried out for 5min, so as to obtain a first dispersion liquid.
And 2, weighing 0.02g of nano silicon dioxide, adding the nano silicon dioxide into 40mL of deionized water, and stirring the mixture for 25min at the rotating speed of 650rpm under the action of a magnetic stirrer to obtain a second dispersion liquid. Wherein the particle size of the nano-silica is about 50 nm.
And 3, stirring and mixing the first dispersion liquid and the second dispersion liquid for 3 hours under a magnetic stirrer to obtain the medicament-silicon dioxide composite antibacterial liquid.
Example 3
The embodiment provides a medicament-silicon dioxide composite antibacterial liquid and a preparation method thereof.
The preparation method of this example includes the following steps:
step 1, weighing 0.04mg of artemisinin and adding to 2mL of acetic acid solution, the pH value of the acid solution is 4, and simultaneously carrying out ultrasonic treatment. The power of the ultrasonic instrument is 250W, the frequency is 40KHz, and the ultrasonic treatment is carried out for 5min, so as to obtain a first dispersion liquid.
And 2, weighing 0.02g of nano silicon dioxide, adding the nano silicon dioxide into 40mL of deionized water, and stirring the mixture for 25min at the rotating speed of 650rpm under the action of a magnetic stirrer to obtain a second dispersion liquid. Wherein the particle size of the nano-silica is about 50 nm.
And 3, stirring and mixing the first dispersion liquid and the second dispersion liquid for 3 hours under a magnetic stirrer to obtain the medicament-silicon dioxide composite antibacterial liquid.
Example 4
The embodiment provides a medicament-silicon dioxide composite antibacterial liquid and a preparation method thereof.
The preparation method of this example includes the following steps:
step 1, weighing 0.05mg of artemisinin and adding to 2mL of acetic acid solution, the pH value of the acid solution is 4, and simultaneously carrying out ultrasonic treatment. The power of the ultrasonic instrument is 250W, the frequency is 40KHz, and the ultrasonic treatment is carried out for 5min, so as to obtain a first dispersion liquid.
And 2, weighing 0.02g of nano silicon dioxide, adding the nano silicon dioxide into 40mL of deionized water, and stirring the mixture for 25min at the rotating speed of 650rpm under the action of a magnetic stirrer to obtain a second dispersion liquid. Wherein the particle size of the nano-silica is about 50 nm.
And 3, stirring and mixing the first dispersion liquid and the second dispersion liquid for 3 hours under a magnetic stirrer to obtain the medicament-silicon dioxide composite antibacterial liquid.
Example 5
The embodiment provides a medicament-silicon dioxide composite antibacterial liquid and a preparation method thereof.
The preparation method of this example includes the following steps:
step 1, weighing 0.06mg of artemisinin and adding to 2mL of acetic acid solution, the pH value of the acid solution is 4, and simultaneously carrying out ultrasonic treatment. The power of the ultrasonic instrument is 250W, the frequency is 40KHz, and the ultrasonic treatment is carried out for 5min, so as to obtain a first dispersion liquid.
And 2, weighing 0.02g of nano silicon dioxide, adding the nano silicon dioxide into 40mL of deionized water, and stirring the mixture for 25min at the rotating speed of 650rpm under the action of a magnetic stirrer to obtain a second dispersion liquid. Wherein the particle size of the nano-silica is about 50 nm.
And 3, stirring and mixing the first dispersion liquid and the second dispersion liquid for 3 hours under a magnetic stirrer to obtain the medicament-silicon dioxide composite antibacterial liquid.
Example 6
The embodiment provides a medicament-silicon dioxide composite antibacterial liquid and a preparation method thereof.
The preparation method of this example includes the following steps:
step 1, weighing 0.02mg of houttuynia cordata, adding the houttuynia cordata into 2mL of silicic acid solution, and carrying out ultrasonic treatment while the pH value of the acid solution is 4. The power of the ultrasonic instrument is 250W, the frequency is 40KHz, and the ultrasonic treatment is carried out for 5min, so as to obtain a first dispersion liquid.
And 2, weighing 0.02g of nano silicon dioxide, adding the nano silicon dioxide into 40mL of deionized water, and stirring the mixture for 25min at the rotating speed of 650rpm under the action of a magnetic stirrer to obtain a second dispersion liquid. Wherein the particle size of the nano-silica is about 50 nm.
And 3, stirring and mixing the first dispersion liquid and the second dispersion liquid for 3 hours under a magnetic stirrer to obtain the medicament-silicon dioxide composite antibacterial liquid.
Example 7
The embodiment provides a medicament-silicon dioxide composite antibacterial liquid and a preparation method thereof.
The preparation method of this example includes the following steps:
step 1, weighing 0.02mg of folium artemisiae argyi, adding the folium artemisiae argyi into 2mL of silicic acid solution, and carrying out ultrasonic treatment while the pH value of the acid solution is 4. The power of the ultrasonic instrument is 250W, the frequency is 40KHz, and the ultrasonic treatment is carried out for 5min, so as to obtain a first dispersion liquid.
And 2, weighing 0.02g of nano silicon dioxide, adding the nano silicon dioxide into 40mL of deionized water, and stirring the mixture for 25min at the rotating speed of 650rpm under the action of a magnetic stirrer to obtain a second dispersion liquid. Wherein the particle size of the nano-silica is about 50 nm.
And 3, stirring and mixing the first dispersion liquid and the second dispersion liquid for 3 hours under a magnetic stirrer to obtain the medicament-silicon dioxide composite antibacterial liquid.
Example 8
The embodiment provides a medicament-silicon dioxide composite antibacterial liquid and a preparation method thereof.
The preparation method of this example includes the following steps:
step 1, weighing 0.02mg of coptis chinensis and adding the coptis chinensis into 2mL of silicic acid solution, wherein the pH value of the acid solution is 4, and simultaneously carrying out ultrasonic treatment. The power of the ultrasonic instrument is 250W, the frequency is 40KHz, and the ultrasonic treatment is carried out for 5min, so as to obtain a first dispersion liquid.
And 2, weighing 0.02g of nano silicon dioxide, adding the nano silicon dioxide into 40mL of deionized water, and stirring the mixture for 25min at the rotating speed of 650rpm under the action of a magnetic stirrer to obtain a second dispersion liquid. Wherein the particle size of the nano-silica is about 50 nm.
And 3, stirring and mixing the first dispersion liquid and the second dispersion liquid for 3 hours under a magnetic stirrer to obtain the medicament-silicon dioxide composite antibacterial liquid.
Example 9
The embodiment provides a medicament-silicon dioxide composite antibacterial liquid and a preparation method thereof.
The preparation method of this example includes the following steps:
step 1, 0.02mg of Andrographis paniculata Nees was weighed into 2mL of silicic acid solution, pH of the acid solution was 4, and sonication was performed simultaneously. The power of the ultrasonic instrument is 250W, the frequency is 40KHz, and the ultrasonic treatment is carried out for 5min, so as to obtain a first dispersion liquid.
And 2, weighing 0.02g of nano silicon dioxide, adding the nano silicon dioxide into 40mL of deionized water, and stirring the mixture for 25min at the rotating speed of 650rpm under the action of a magnetic stirrer to obtain a second dispersion liquid. Wherein the particle size of the nano-silica is about 50 nm.
And 3, stirring and mixing the first dispersion liquid and the second dispersion liquid for 3 hours under a magnetic stirrer to obtain the medicament-silicon dioxide composite antibacterial liquid.
Example 10
The embodiment provides a medicament-silicon dioxide composite antibacterial liquid and a preparation method thereof.
The preparation method of this example includes the following steps:
step 1, 0.02mg of dandelion was weighed into 2mL of silicic acid solution, the pH of the acid solution was 4, and ultrasonic treatment was performed at the same time. The power of the ultrasonic instrument is 250W, the frequency is 40KHz, and the ultrasonic treatment is carried out for 5min, so as to obtain a first dispersion liquid.
And 2, weighing 0.02g of nano silicon dioxide, adding the nano silicon dioxide into 40mL of deionized water, and stirring the mixture for 25min at the rotating speed of 650rpm under the action of a magnetic stirrer to obtain a second dispersion liquid. Wherein the particle size of the nano-silica is about 50 nm.
And 3, stirring and mixing the first dispersion liquid and the second dispersion liquid for 3 hours under a magnetic stirrer to obtain the medicament-silicon dioxide composite antibacterial liquid.
Example 11
The embodiment provides a medicament-silicon dioxide composite antibacterial liquid and a preparation method thereof.
The preparation method of this example includes the following steps:
step 1, 0.02mg of licorice was weighed into 2mL of carbonic acid solution, pH of the acid solution was 4, and ultrasonic treatment was performed simultaneously. The power of the ultrasonic instrument is 250W, the frequency is 40KHz, and the ultrasonic treatment is carried out for 5min, so as to obtain a first dispersion liquid.
And 2, weighing 0.02g of nano silicon dioxide, adding the nano silicon dioxide into 40mL of deionized water, and stirring the mixture for 25min at the rotating speed of 650rpm under the action of a magnetic stirrer to obtain a second dispersion liquid. Wherein the particle size of the nano-silica is about 50 nm.
And 3, stirring and mixing the first dispersion liquid and the second dispersion liquid for 3 hours under a magnetic stirrer to obtain the medicament-silicon dioxide composite antibacterial liquid.
Example 12
The embodiment provides a medicament-silicon dioxide composite antibacterial liquid and a preparation method thereof.
The preparation method of this example includes the following steps:
step 1, 0.02mg of saponin was weighed into 2mL of carbonic acid solution, the pH of the acid solution was 4, and ultrasonic treatment was performed simultaneously. The power of the ultrasonic instrument is 250W, the frequency is 40KHz, and the ultrasonic treatment is carried out for 5min, so as to obtain a first dispersion liquid.
And 2, weighing 0.02g of nano silicon dioxide, adding the nano silicon dioxide into 40mL of deionized water, and stirring the mixture for 25min at the rotating speed of 650rpm under the action of a magnetic stirrer to obtain a second dispersion liquid. Wherein the particle size of the nano-silica is about 50 nm.
And 3, stirring and mixing the first dispersion liquid and the second dispersion liquid for 3 hours under a magnetic stirrer to obtain the medicament-silicon dioxide composite antibacterial liquid.
Example 13
The embodiment provides a medicament-silicon dioxide composite antibacterial liquid and a preparation method thereof.
The preparation method of this example includes the following steps:
step 1, weighing 0.02mg of scutellaria baicalensis, adding into 2mL of carbonic acid solution, and carrying out ultrasonic treatment while the pH value of the acid solution is 4. The power of the ultrasonic instrument is 250W, the frequency is 40KHz, and the ultrasonic treatment is carried out for 5min, so as to obtain a first dispersion liquid.
And 2, weighing 0.02g of nano silicon dioxide, adding the nano silicon dioxide into 40mL of deionized water, and stirring the mixture for 25min at the rotating speed of 650rpm under the action of a magnetic stirrer to obtain a second dispersion liquid. Wherein the particle size of the nano-silica is about 50 nm.
And 3, stirring and mixing the first dispersion liquid and the second dispersion liquid for 3 hours under a magnetic stirrer to obtain the medicament-silicon dioxide composite antibacterial liquid.
Comparative example 1
The comparative example is a nano silicon dioxide dispersion, and the preparation method comprises the following steps:
0.02g of nano-silica is weighed and added into 40mL of deionized water, and the mixture is stirred for 25min at the rotating speed of 650rpm under the action of a magnetic stirrer, so that nano-silica dispersion liquid is obtained. Wherein the particle size of the nano-silica is about 50 nm.
Comparative example 2
The comparative example is a nano silicon dioxide dispersion, and the preparation method comprises the following steps:
0.04g of nano silicon dioxide is weighed and added into 40mL of deionized water, and the mixture is stirred for 25min at the rotating speed of 650rpm under the action of a magnetic stirrer, so that nano silicon dioxide dispersion liquid is obtained. Wherein the particle size of the nano-silica is about 50 nm.
Comparative example 3
The comparative example is a medicament dispersion liquid, and the preparation method comprises the following steps:
0.02mg of artemisinin was weighed into 2mL of acetic acid solution at pH 4 and sonicated. The power of the ultrasonic instrument is 250W, the frequency is 40KHz, and the ultrasonic treatment is carried out for 5min, so as to obtain the medicine dispersion liquid.
Comparative example 4
The comparative example is a pharmaceutical dispersion, the preparation method comprising the steps of:
0.02mg of licorice was weighed into 2mL of an acetic acid solution, and the pH of the acid solution was 4 while ultrasonic treatment was performed. The power of the ultrasonic instrument is 250W, the frequency is 40KHz, and the ultrasonic treatment is carried out for 5min, so as to obtain the medicine dispersion liquid.
Comparative example 5
The comparative example provides a composite antibacterial liquid, and the preparation method comprises the following steps:
step 1, weighing 0.02mg of artemisinin, adding the artemisinin into deionized water, and carrying out ultrasonic treatment simultaneously. The power of the ultrasonic instrument is 250W, the frequency is 40KHz, and the ultrasonic treatment is carried out for 5min, so as to obtain a first dispersion liquid.
And 2, weighing 0.02g of nano silicon dioxide, adding the nano silicon dioxide into 40mL of deionized water, and stirring the mixture for 25min at the rotating speed of 650rpm under the action of a magnetic stirrer to obtain a second dispersion liquid. Wherein the particle size of the nano-silica is about 50 nm.
And 3, stirring and mixing the first dispersion liquid and the second dispersion liquid for 3 hours under a magnetic stirrer to obtain the medicament-silicon dioxide composite antibacterial liquid.
The photograph of the drug-silica composite antibacterial solution obtained in example 1 is shown in fig. 1.
The products obtained in examples 1 to 13 and comparative examples 1 to 5 were subjected to an antibacterial test, and the Minimum Inhibitory Concentrations (MIC) of the products against Escherichia coli and Staphylococcus aureus were respectively tested. The test results are shown in table 1.
TABLE 1 minimum inhibitory concentrations of the product against E.coli and Staphylococcus aureus
According to the medicament-silicon dioxide composite antibacterial liquid and the preparation method thereof, the first dispersion liquid containing the medicament and the second dispersion liquid containing the nano-silicon dioxide are stirred and mixed to obtain a composite product of the organic antibacterial agent and the inorganic antibacterial agent, and the antibacterial capability is more comprehensive. The nano silicon dioxide is used as a nano antibacterial material, has the characteristics of stronger transmembrane capacity, function of inhibiting discharge, difficulty in inducing bacterial drug resistance and the like, the medicament is selected from at least one of artemisinin, folium artemisiae argyi, coptis chinensis, common andrographis herb, houttuynia cordata, liquorice, saponin, scutellaria baicalensis and dandelion, the medicament is obtained from natural Chinese herbal medicines, the natural Chinese herbal medicines have good antibacterial action, relatively small adverse reaction and difficulty in generating drug resistance, the medicament enables the composite antibacterial liquid to have the functions of resisting bacteria and fungi and also has the functions of resisting viruses and diminishing inflammation, and the medicament-silicon dioxide composite antibacterial liquid is mild, non-irritant, safe and free of toxic and side effects.
The technical features of the embodiments described above may be arbitrarily combined, and for the sake of brevity, all possible combinations of the technical features in the embodiments described above are not described, but should be considered as being within the scope of the present specification as long as there is no contradiction between the combinations of the technical features.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. The preparation method of the medicament-silicon dioxide composite antibacterial liquid is characterized by comprising the following steps of:
dispersing a medicament in an acid solution to obtain a first dispersion liquid, wherein the pH value of the acid solution is 3-5, and the medicament is at least one selected from artemisinin, folium artemisiae argyi, coptis chinensis, common andrographis herb, heartleaf houttuynia herb, liquorice, saponin, scutellaria baicalensis and dandelion;
dispersing nano silicon dioxide in water to obtain a second dispersion liquid;
and stirring and mixing the first dispersion liquid and the second dispersion liquid to obtain the medicament-silicon dioxide composite antibacterial liquid.
2. The method for preparing the agent-silica composite antibacterial solution according to claim 1, wherein the acid solution is at least one selected from the group consisting of carbonic acid, silicic acid, hypochlorous acid, acetic acid and phosphoric acid.
3. The method for preparing the agent-silica composite antibacterial liquid according to claim 1, wherein the ultrasonic treatment is performed while the agent is dispersed in the acid solution.
4. The method for preparing the medicament-silica composite antibacterial liquid according to claim 3, wherein the power of the ultrasonic treatment is 200W to 400W, and the frequency is 30KHz to 50 KHz.
5. The method for producing the agent-silica composite antibacterial liquid according to claim 1, wherein the time for stirring and mixing the first dispersion and the second dispersion is 3 to 6 hours.
6. The method for producing the drug-silica composite antibacterial liquid according to claim 1, wherein the concentration of the drug in the first dispersion is 0.01mg/mL to 0.03 mg/mL.
7. The method for preparing the drug-silica composite antibacterial solution according to claim 1, wherein the concentration of the second dispersion is 0.25mg/mL to 0.75 mg/mL.
8. The method for preparing the agent-silica composite antibacterial liquid according to claim 1, wherein the nano-silica has a particle size of 30nm to 60 nm.
9. The method for preparing the agent-silica composite antibacterial liquid according to any one of claims 1 to 8, wherein the mass ratio of the agent to the nano silica is 1: 1-1: 7.
10. The agent-silica composite antibacterial liquid, which is prepared by the preparation method according to any one of claims 1 to 9.
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