CN114487455A - In-vitro diagnostic instrument and control method thereof - Google Patents
In-vitro diagnostic instrument and control method thereof Download PDFInfo
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- CN114487455A CN114487455A CN202210135573.XA CN202210135573A CN114487455A CN 114487455 A CN114487455 A CN 114487455A CN 202210135573 A CN202210135573 A CN 202210135573A CN 114487455 A CN114487455 A CN 114487455A
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- card
- pressure valve
- reagent card
- vitro diagnostic
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/00584—Control arrangements for automatic analysers
Abstract
The invention discloses an in vitro diagnostic apparatus and a control method thereof, wherein the in vitro diagnostic apparatus comprises a card inserting device and a pressure valve device; the card inserting device is provided with an inserting groove for inserting a reagent card; the pressure valve device comprises at least one pressure valve piece, each pressure valve piece is movably arranged in the card inserting device in a penetrating mode, and the pressure valve pieces can stretch into the insertion groove to be abutted to the reagent card. The scheme that this external diagnostic instrument and control method provided wears to locate through the activity of pressure valve member the plug-in card device, and the pressure valve member can stretch into the inserting groove of plug-in card device in order to offset with the reagent card, so that press the relative inserting device of valve member to when stretching into this inserting groove, press the covering rete that the valve member can extrude on the reagent card, the flow passage hole that the reagent card can be laminated to the covering rete after extrusion deformation, can be with the runner shutoff of this reagent card in order to break off the intercommunication, so, can realize independently opening or the disconnection of each runner of accurate control through each pressure valve member, thereby realize opening or the disconnection of each runner of accurate control.
Description
Technical Field
The invention belongs to the technical field of medical instruments, and particularly relates to an in-vitro diagnostic instrument and a control method thereof.
Background
In the field of in vitro diagnostic detection technology, a reagent card is inserted into a sample to be detected and a reagent, and the sample is detected by placing the reagent card in an in vitro diagnostic detection analyzer. When blood samples of different projects need to be detected, the reagent card is provided with different flow channels, and each flow channel can correspondingly detect the blood samples of one project. However, the conventional reagent card is generally fixed inside an in vitro diagnostic apparatus for detection, and it is difficult to individually and accurately control the opening or the disconnection of each flow channel of the reagent card, which affects the detection efficiency and the detection effect.
Disclosure of Invention
The invention aims to provide an in-vitro diagnostic instrument which is used for overcoming the defect that the opening or the disconnection of each flow channel of a reagent card is difficult to be independently and accurately controlled in the detection process of the reagent card integrated with multiple flow channels in the prior art, so that the detection efficiency and the detection effect are influenced.
The technical scheme is as follows:
the in-vitro diagnostic instrument comprises a card inserting device and a pressure valve device; the card inserting device is provided with an inserting groove for inserting a reagent card; the pressure valve device comprises at least one pressure valve, each pressure valve movably penetrates through the card inserting device, and the pressure valves can extend into the inserting grooves to abut against the reagent cards.
In one embodiment, the pressure valve means further comprises a pressure valve body and at least one first actuating means; press the valve body at least part to arrange in the inserting groove, press the valve body with press a swing joint, a drive arrangement with press a one-to-one setting, and each a drive arrangement can drive one press the valve relatively press the valve body to move to stretching into the inserting groove.
In one embodiment, the output end of the first driving device is at least partially arranged opposite to the valve pressing member, and the output end of the first driving device can move to press against the valve pressing member.
In one embodiment, the pressure valve device further comprises a first resilient member; the pressure valve part is provided with a blocking part, the first elastic part is arranged between the blocking part and the pressure valve body, and the acting force of the first elastic part on the pressure valve part is opposite to that of the first driving device.
In one embodiment, the pressure valve body is provided with at least one through connecting hole, and the connecting holes are arranged in the pressure valve body in an array structure; the connecting hole with press the valve member one-to-one setting, just press the valve member activity to wear to locate in the connecting hole.
In one embodiment, at least one sensing element for sensing liquid flow is further arranged at one end of the pressure valve body close to the insertion groove, and the sensing element is embedded in the pressure valve body.
In one embodiment, the pressure valve means further comprises first heating means; first heating device includes first heating film and first heat-conducting plate, first heat-conducting plate with press the valve body to be close to the one end of inserting groove is connected, first heating film set up in first heat-conducting plate is close to press one side of valve body.
In one embodiment, the in-vitro diagnostic apparatus further comprises a stirring device connected with the pressure valve device;
the stirring device comprises a power assembly and an acting piece, the power assembly can drive the acting piece to move, a driving force for covering at least part of the region of the insertion groove can be formed when the acting piece moves, and the driving force is used for driving a driven piece located in the covered region to move.
In one embodiment, the power assembly comprises a rotating device, a conversion assembly and a movable piece;
the output end of the rotating device is connected with the conversion component, the moving part is connected with the conversion component, and the rotating device drives the moving part to reciprocate along the linear direction through the conversion component; the action piece is arranged on the moving piece.
In one embodiment, the conversion assembly comprises a cam and a guide assembly; the output end of the rotating device is connected with the cam, the moving part is meshed with the cam and movably arranged on the guide assembly, and the rotating device drives the cam to rotate and can drive the moving part to move linearly along the guide assembly.
In one embodiment, the conversion component further comprises a second elastic component, the movable component is connected with the guide component through the second elastic component, and the movable component is always in meshing transmission with the cam under the action of the second elastic component.
In one embodiment, the acting element is a magnetic element capable of generating a magnetic attraction force or a magnetic repulsion force for attracting or repelling the driven element, and the magnetic attraction force or the magnetic repulsion force is the driving force.
In one embodiment, the card plug-in device comprises a card plug-in main body and a first positioning component and a second positioning component which are movably connected with the card plug-in main body;
the card inserting main body is provided with the inserting groove; the first positioning assembly can at least partially extend into the insertion groove to perform primary positioning on the reagent card inserted into the insertion groove, and the second positioning assembly can at least partially extend into the insertion groove to perform secondary positioning on the reagent card inserted into the insertion groove.
In one embodiment, the first positioning component comprises a first positioning piece, and the first positioning piece is arranged on the card insertion main body and elastically extends into the insertion groove along the front surface of the card insertion main body; the second positioning assembly comprises a pressing and clamping assembly and a second positioning piece, the pressing and clamping assembly is movably arranged on the back face of the card inserting main body, and the second positioning piece is arranged on one side, close to the insertion groove, of the pressing and clamping assembly.
In one embodiment, the first positioning element further includes a third positioning element, and the third positioning element is disposed on the card insertion body and elastically extends into the insertion slot along a side surface of the card insertion body.
In one embodiment, the second positioning assembly further comprises a second driving device, and the second driving device drives the card pressing assembly to move back and forth towards or away from the inserting slot.
In one embodiment, the clamping component comprises a clamping plate and a second heating device; the output end of the second driving device is connected with the card pressing plate, and the second heating device is arranged on one side, facing the inserting groove, of the card pressing plate.
In one embodiment, the second heating device comprises a second heating film and a second heat-conducting plate, the second heat-conducting plate is connected with the card pressing plate, and the second heating film is arranged on one side, close to the card pressing plate, of the second heat-conducting plate.
In one embodiment, the in vitro diagnostic apparatus further comprises a suction power source; the pressure cardboard still has at least one inlet channel, inlet channel has the inlet end and gives vent to anger the end, the inlet end at least part stretches out the pressure cardboard and towards the inserting groove, just the inlet end stretches out the end that presses the cardboard is the loop configuration, the inlet end is used for sealing the intercommunication with the gas pocket of reagent card, give vent to anger the end with the power source intercommunication of bleeding.
In one embodiment, the pressure clamping plate is also provided with at least one pressure detection hole; the in-vitro diagnostic instrument further comprises a first pressure sensor and a sealing ring, and the first pressure sensor is arranged in the pressure detection hole in a sealing mode through the sealing ring.
In one embodiment, the insertion groove comprises a first insertion groove and a second insertion groove which are communicated with each other; the in-vitro diagnostic instrument further comprises an identification module and a reading module, wherein the identification module and the reading module are arranged on the card inserting device, the identification module is used for identifying the inserting state of the first slot, and the reading module is used for reading the information of the reagent card inserted into the second slot.
In one embodiment, the card insertion device includes a card insertion body, a notch is further formed in a top end of the card insertion body, the first slot and the second slot are vertically formed in the card insertion body, the notch, the first slot and the second slot are sequentially communicated, the identification module is disposed at a position of the card insertion body corresponding to the first slot, and the reading module is disposed at a position of the card insertion body corresponding to the first slot or the second slot.
In one embodiment, the in-vitro diagnostic apparatus further comprises an air source device, the air source device comprises a tank body and an air path system, the tank body is provided with a first cavity and a second cavity, the second cavity is controlled by the air path system to be communicated with the first cavity, the first cavity is used for being communicated with a flow channel of a reagent card for air supply, and the volume of the first cavity is larger than that of the second cavity.
In one embodiment, the air path system comprises a main air path, a branch air path and a one-way valve; the first cavity and the second cavity are respectively pressurized through the main gas circuit external gas generating device, the first cavity and the second cavity are communicated through the gas distributing circuit, and the one-way valve is arranged on the gas distributing circuit so that gas can enter the first cavity from the second cavity.
A control method of an in-vitro diagnostic apparatus, the control method being based on the in-vitro diagnostic apparatus as described above, comprising the steps of:
inserting a reagent card into an insertion slot of the card insertion device, the reagent card having at least one flow channel covered by a cover film layer;
controlling at least one pressure valve part of the pressure valve device to move relative to the inserting and clamping device until the pressure valve part extends into the inserting and clamping groove or extends out of the inserting and clamping groove; the pressure valve piece extends into the insertion groove and abuts against the reagent card, and a covering film layer of the reagent card is extruded to seal the flow channel; the pressure valve piece extends out of the insertion groove and then is separated from the reagent card, and the flow channel is communicated.
The technical scheme provided by the invention has the following advantages and effects:
this external diagnostic instrument wears to locate through pressing the valve part activity the plug-in card device, and the valve part that presses can stretch into the inserting groove to the plug-in card device in order to offset with the reagent card, so that press the relative plug-in card device of valve part to when stretching into this inserting groove, press the valve part this moment and can extrude the cover rete on the reagent card, cover the rete and can laminate the flow passage hole of reagent card after extrusion deformation, can be with the runner shutoff of this reagent card in order to break off the intercommunication, so, can realize independently opening or breaking of each runner of accurate control through each pressure valve part, thereby realize opening or breaking off of each runner of accurate control.
Drawings
The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the invention and, together with the description, serve to explain the principles and effects of the invention.
Unless otherwise specified or defined, the same reference numerals in different figures refer to the same or similar features, and different reference numerals may be used for the same or similar features.
FIG. 1 is a schematic perspective view of an in vitro diagnostic apparatus according to an embodiment of the present invention;
FIG. 2 is a schematic view of an assembled structure of a detecting mechanism of the in-vitro diagnostic apparatus of FIG. 1;
FIG. 3 is a schematic view of an angled assembly of the pressure valve assembly and the card insertion assembly;
FIG. 4 is a schematic longitudinal cross-sectional view of the pressure valve assembly and card insertion assembly mounting structure of FIG. 3;
FIG. 5 is a schematic view of an alternate angle of assembly of the pressure valve apparatus and paddle card apparatus of FIG. 3;
fig. 6 is a cross-sectional structural diagram of the card insertion device of fig. 5;
fig. 7 is an exploded view of the card insertion device of fig. 5;
FIG. 8 is an exploded view of the card hopper mounting member;
FIG. 9 is an exploded view of the card pressing assembly of the card insertion device;
FIG. 10 is an exploded view of a second driving device of the card pressing assembly;
FIG. 11 is a cross-sectional view of the card press body of the card press assembly;
FIG. 12 is another cross-sectional structural view of the card press body of the card press assembly;
FIG. 13 is a front view of the press-clamping plate;
fig. 14 is a schematic perspective view of a pressure valve device;
FIG. 15 is an exploded view of a portion of the structure of the pressure valve assembly of FIG. 14;
fig. 16 is a schematic view of the valve means and card means of fig. 3 in an unassembled state;
FIG. 17 is a schematic cross-sectional view showing a partial structure of the pressure valve device of FIG. 13;
FIG. 18 is a schematic cross-sectional view of a stirring device;
FIG. 19 is an exploded view of the stirring device;
fig. 20 is an exploded view schematically showing another partial structure of the pressure valve device of fig. 14;
FIG. 21 is a schematic view of the mounting structure of the first driving device;
FIG. 22 is a schematic perspective view of the air supply assembly;
FIG. 23 is an exploded view of the gas supply assembly;
FIG. 24 is a schematic longitudinal sectional view of the can body;
FIG. 25 is a schematic view of the connection structure of the air passage system;
FIG. 26 is a schematic view showing the state where the in-vitro diagnostic apparatus is inserted with a reagent card;
FIG. 27 is a schematic front view of a reagent card;
FIG. 28 is a schematic view of the back side of the reagent card;
fig. 29 is an exploded view of the reagent card.
Description of reference numerals:
100. an in vitro diagnostic instrument;
10. a detection mechanism;
1. a pressure valve means; 11. a pressure valve body; 111. a valve body; 112. a valve cover member; 113. connecting holes; 12. pressing the valve piece; 121. a blocking member; 13. a first elastic member; 14. an inductive element; 15. a first heating device; 151. a first heating film; 152. a first heat-conducting plate; 153. a floating connection member; 154. connecting columns; 155. a limiting part; 156. an elastic portion; 157. a second temperature sensing member; 16. a first driving device; 17. driving the fixed seat; 171. an opto-coupler sensor; 18. driving a pressure head;
2. a card insertion device; 21. a card insertion main body; 211. inserting grooves; 2111. a first slot; 2112. a second slot; 212. a base plate; 213. a top plate; 214. a side plate; 22. a first positioning assembly; 221. a first positioning member; 222. a third positioning member; 223. an elastic mounting member; 2231. a spring fastener; 2232. a third elastic member; 2233. the spring clip mounting base body; 224. a locking member; 225. pressing the clamping strip; 23. a second positioning assembly; 231. pressing the card assembly; 2311. pressing the clamping plate; 2312. a second heating film; 2313. a second heat-conducting plate; 2314. a first temperature sensing member; 2315. an intake passage; 2316. a first pressure sensor; 2317. a seal ring; 2318. an air extraction channel; 2319. a pressure detection hole; 232. a second positioning member; 233. a second driving device; 234. a linear guide; 24. a covering component; 241. a rotating plate; 242. a rotating shaft; 243. mounting a plate; 244. a tension spring; 245. e-shaped clamp springs; 25. an identification module; 251. an infrared radiation module; 252. an infrared receiving module; 26. a reading module; 27. a status indicator light;
3. a stirring device; 31. a rotating device; 32. a conversion component; 321. a cam; 322. a guide assembly; 3221. a guide member; 3222. a slider; 323. a second elastic member; 33. a movable member; 34. an acting element; 35. a driven wheel; 36. a mounting seat;
4. an air supply device; 41. a tank body; 411. a first chamber; 412. a second chamber; 413. a first open end; 414. a second open end; 415. a first end cap; 4151. a first annular groove; 416. a second end cap; 417. a first seal member; 418. a second seal member; 42. a gas path system; 421. a main gas path; 422. gas path distribution; 423. a one-way valve; 424. a first pressure relief air passage; 425. a first on-off valve; 426. a first speed regulating valve; 427. a second pressure relief air passage; 428. a second on-off valve; 429. a second speed regulating valve; 431. a third pressure relief air path; 432. a third on-off valve; 433. a fourth pressure relief air path; 434. a fourth switching valve; 435. a second pressure sensor; 436. a fifth on-off valve; 437. a third pressure sensor; 438. and a sixth switching valve.
5. A mounting frame; 51. a touch screen; 52. a printer; 53. a frame body; 54. a first layer body; 55. a second layer; 6. a plunger pump;
200. a reagent card; 210. a reagent chamber; 220. a flow channel; 230. a flow passage hole; 240. covering the film layer; 300. a blood collection tube; 310. a blood tube rack; 320. and (4) inserting a pipeline.
Detailed Description
In order to facilitate an understanding of the invention, specific embodiments thereof will be described in more detail below with reference to the accompanying drawings.
Unless specifically stated or otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In the case of combining the technical solutions of the present invention in a realistic scenario, all technical and scientific terms used herein may also have meanings corresponding to the purpose of achieving the technical solutions of the present invention.
As used herein, unless otherwise specified or defined, "first" and "second" … are used merely for name differentiation and do not denote any particular quantity or order.
As used herein, the term "and/or" includes any and all combinations of one or more of the associated listed items, unless specified or otherwise defined.
It will be understood that when an element is referred to as being "secured to" another element, it can be directly secured to the other element or intervening elements may also be present; when an element is referred to as being "connected" to another element, it can be directly connected to the other element or intervening elements may also be present; when an element is referred to as being "mounted on" another element, it can be directly mounted on the other element or intervening elements may also be present. When an element is referred to as being "on" another element, it can be directly on the other element or intervening elements may also be present.
The in vitro diagnostic apparatus 100 can be used for testing blood samples for different items, and in this embodiment, the in vitro diagnostic apparatus 100 can be used for testing blood coagulation, thrombus formation, and the like. Further, as shown in fig. 27 to fig. 29, the reagent card 200 of the present embodiment has a covering film 240, the reagent card 200 has a reagent cavity 210, a flow channel 220, a flow channel hole 230, a card fixing hole, and the like, and the covering film 240 is disposed on the reagent card 200 and covers the reagent cavity 210, the flow channel 220, the flow channel hole 230, the card fixing hole, and the like; it should be further noted that the flow channel 220 of the reagent card 200 is formed by matching a hole channel opened on the front surface of the reagent card 200 with a hole channel opened on the back surface of the reagent card 200, and each of the flow channel hole 230, the reagent cavity 210 and the fixing hole may be correspondingly disposed on the flow channel 220 on the front surface or the back surface of the reagent card 200. As shown in fig. 1 to 29, the in-vitro diagnostic apparatus 100 is integrated with a card insertion device 2, a pressure valve device 1, a stirring device 3, an air source device 4, a control system, etc., and the components can be automatically controlled by the control system to form automatic detection.
Specifically, as shown in fig. 1 and fig. 2, each component of the in-vitro diagnostic apparatus 100 may be integrated on one mounting frame 5, the mounting frame 5 may be an open structure, or in other embodiments, the mounting frame 5 may form a cavity by providing a mounting bottom plate, a front mounting plate, a left mounting plate, a right mounting plate, an upper fixing plate, and a back cover plate, where a mounting position for mounting each component is formed in the cavity, and the mounting frame 5 may protect internal core components and hardware thereof, so as to avoid being influenced by an external environment during a detection process performed in the mounting frame 5. The mount 5 may be provided with a touch panel 51, a printer 52, and the like, and is not particularly limited.
The present embodiment provides an in vitro diagnostic apparatus 100, as shown in fig. 3 to 29, the in vitro diagnostic apparatus 100 includes a card insertion device 2 and a pressure valve device 1; the card insertion device 2 has an insertion slot 211 for inserting the reagent card 200; it should be noted that the reagent card 200 inserted into the insertion slot 211 has a plurality of flow paths 220, and each flow path 220 can perform a test item, so that a plurality of tests of different items can be integrated into one reagent card 200. The pressure valve device 1 comprises at least one pressure valve 12, each pressure valve 12 is movably arranged in the card inserting device 2 in a penetrating way, and the pressure valve 12 can extend into the insertion groove 211 to be propped against the reagent card 200. It can be understood that, press valve member 12 to move to stretching into this inserting groove 211 relatively to plug-in card device 2, press valve member 12 this moment can extrude the covering rete 240 on the reagent card 200, cover rete 240 can laminate the runner hole 230 of reagent card 200 after extrusion deformation, can be with the runner 220 shutoff of this reagent card 200 with the disconnection intercommunication to can realize the independent opening or the disconnection of each runner 220 of accurate control through each pressure valve member 12.
In summary, the in vitro diagnostic apparatus 100 movably penetrates the card insertion device 2 through the pressure valve member 12, and the pressure valve member 12 can extend into the insertion groove 211 of the card insertion device 2 to abut against the reagent card 200, so that when the pressure valve member 12 moves relative to the card insertion device 2 to extend into the insertion groove 211, the pressure valve member 12 can extrude the covering film 240 on the reagent card 200, the covering film 240 can be attached to the channel hole 230 of the reagent card 200 after being extruded and deformed, and the channel 220 of the reagent card 200 can be plugged to disconnect the connection, so that the independent opening or the disconnection of each channel 220 can be accurately controlled through each pressure valve member 12, and the opening or the disconnection of each channel 220 can be accurately controlled.
In some embodiments, as shown in fig. 5 to 13, the card insertion apparatus 2 includes a card insertion body 21, and a first positioning component 22 and a second positioning component 23 movably connected to the card insertion body 21; the card insertion body 21 has an insertion groove 211; specifically, in this embodiment, the card insertion main body 21 includes a bottom plate 212, a top plate 213 and three side plates 214, the bottom plate 212 and the top plate 213 are disposed opposite to each other, the bottom plate 212 and the top plate 213 are connected by the three side plates 214, and the bottom plate 212, the top plate 213 and the three side plates 214 enclose a slot 211 having a window, wherein the window is located at a front position of the reagent card 200 after the slot 211 is inserted into the reagent card 200. It should be further noted that the reagent card 200 has a flow channel 220, a reagent chamber 210, etc. disposed on the front surface thereof, and the reagent card 200 has a card-fixing hole, etc. for positioning on the back surface thereof.
The first positioning member 22 is at least partially inserted into the insertion groove 211 to primarily position the reagent card 200 inserted into the insertion groove 211, and the second positioning member 23 is at least partially inserted into the insertion groove 211 to secondarily position the reagent card 200 inserted into the insertion groove 211. It can be understood that, all set up in plug-in card main part 21 through first locating component 22 and second locating component 23 activity, consequently can stretch into inserting groove 211 through first locating component 22 in advance and carry out initial positioning to the reagent card 200 that is located in inserting groove 211, after initial positioning is accomplished, rethread second locating component 23 stretches into inserting groove 211 and carries out secondary positioning to reagent card 200, so that this reagent card 200 can form dual location through first locating component 22 and the cooperation of second locating component 23, the mode of dual location can make reagent card 200 insert and be located in inserting groove 211 accurately, and can make reagent card 200 firmly be fixed in the preset position of inserting groove 211, thereby improve stability and the accuracy that reagent card 200 inserted.
In some embodiments, as shown in fig. 6, the first positioning component 22 includes a first positioning member 221, the first positioning member 221 is disposed on the card main body 21 and elastically extends into the insertion slot 211 along the front surface of the card main body 21; it can be understood that the front of the card insertion main body 21 corresponds to the front of the reagent card 200, the back of the card insertion main body 21 corresponds to the back of the reagent card 200, the first positioning member 221 elastically extends into the insertion groove 211 towards the front of the card insertion main body 21, and can perform initial positioning in the Y-axis direction on the reagent card 200 inserted into the insertion groove 211, wherein the first positioning member 221 may be a ball plunger, and specifically may be disposed on the left and right sides of the window of the insertion groove 211 through two pressing bars 225, the ball plunger is disposed on the pressing bars 225 and elastically extends into the insertion groove 211, and the ball plunger can elastically press the front of the reagent card 200. The X-axis direction, the Y-axis direction, and the Z-axis direction of the reagent card 200 correspond to three directions of the three-dimensional space of the reagent card 200, wherein the X-axis direction corresponds to the longitudinal direction of the reagent card 200, the Y-axis direction corresponds to the width direction of the reagent card 200, and the Z-axis direction corresponds to the height direction of the reagent card 200. The second positioning assembly 23 includes a card pressing assembly 231 and a second positioning member 232, the card pressing assembly 231 is movably disposed on the back of the card inserting main body 21, and the second positioning member 232 is disposed on one side of the card pressing assembly 231 close to the inserting slot 211. It can be understood that, after the first positioning component 22 initially positions the reagent card 200, a margin is left between the reagent card 200 and the insertion groove 211, the card pressing component 231 moves toward the back of the reagent card 200, the second positioning component 232 on the card pressing component 231 is inserted into the corresponding card positioning hole on the back of the reagent card 200, at this time, the second positioning component 232 performs secondary positioning on the reagent card 200, and the first positioning component 221 is matched to extend the reagent card 200 into the insertion groove 211 in the front direction, so that the reagent card 200 can be doubly positioned in the front and back directions, and the reagent card 200 is accurately inserted into and positioned in the insertion groove 211.
In some embodiments, as shown in fig. 6, the first positioning assembly 22 further includes a third positioning element 222, and the third positioning element 222 is disposed on the card insertion body 21 and elastically extends into the insertion slot 211 along a side surface of the card insertion body 21. It can be understood that the side surface of the card insertion body 21 corresponds to the side surface of the reagent card 200, and the third positioning member 222 elastically extends into the insertion groove 211 towards the side surface of the card insertion body 21, so as to perform the initial positioning in the X-axis direction on the reagent card 200 inserted into the insertion groove 211; specifically, the third positioning element 222 may be a compression roller, which facilitates the smooth insertion of the reagent card 200 into the insertion groove 211 and can elastically extend into the insertion groove 211 to position the reagent card 200 in the X-axis direction. Therefore, the first positioning member 221 and the third positioning member 222 are engaged with each other, so that the reagent card 200 can be initially positioned in the insertion slot 211 in the longitudinal direction and the width direction, and the reagent card 200 can be fixed in the insertion slot 211 by the first positioning member 221 and the third positioning member 222 abutting against the front surface and the side surface of the reagent card 200, thereby effectively preventing the reagent card 200 from moving relative to the insertion slot 211.
In some embodiments, as shown in fig. 6-8, first positioning assembly 22 further includes a resilient mount 223 and a retaining member 224; elastic mounting member 223 sets up in the tank bottom of inserting groove 211, and retaining member 224 sets up in the position that plug-in card main part 21 is located between the groove top of elastic mounting member 223 and inserting groove 211, and elastic mounting member 223 is used for driving reagent card 200 and moves to retaining member 224 locking reagent card 200 towards the groove top direction of inserting groove 211. It can be understood that, an external force is applied to the reagent card 200, so that the reagent card 200 is inserted into the insertion groove 211 and the bottom end of the reagent card 200 abuts against the bottom of the insertion groove 211, the reagent card 200 compresses the elastic mounting member 223, and then the external force is removed, and the elastic mounting member 223 can drive the reagent card 200 to move to a preset position in the direction of the top of the insertion groove 211 in the process of recovering the state, that is, the reagent card 200 is driven by the elastic mounting member 223 to perform Z-axis direction adjustment, and at this time, the locking member 224 locks and positions the reagent card 200. Therefore, through the cooperation of resilient mounting spare 223 and retaining member 224, can carry out the adjustment and the location of Z axle direction to reagent card 200 to through the cooperation of first locator 221 and third locator 222, can carry out X axle direction, Y axle direction and Z axle direction to reagent card 200 and fix a position and adjust, make reagent card 200 tentatively fix a position and be fixed in inserting groove 211. In addition, the elastic mounting member 223 may be provided with an in-position sensor, through which the control system senses the insertion state of the reagent card 200 after the initial positioning of the reagent card 200 is completed.
Specifically, in this embodiment, the locking member 224 is an elastic self-locking bar for locking with the locking hole of the reagent card 200 in a matching manner, when the reagent card 200 is inserted into the insertion slot 211, the reagent card 200 presses the elastic self-locking bar, the elastic self-locking bar is compressed and retracts into the card insertion body 21, when the reagent card 200 moves upward under the driving of the elastic mounting member 223, and the locking hole of the reagent card 200 moves to correspond to the elastic self-locking bar, the elastic self-locking bar resets and extends into the locking hole of the reagent card 200 to perform positioning and locking of the reagent card 200, so as to prevent the reagent card 200 from moving upward, and complete positioning of the reagent card 200 in the Z-axis direction. In addition, the elastic mounting member 223 includes a latch mounting base 2233, a latch 2231 and a third elastic member 2232, the latch 2231 is elastically mounted on the latch mounting base 2233 by the third elastic member 2232, and the latch mounting base 2233 is disposed on the bottom of the slot 211, so that the latch 2231 can have elastic performance in the Z-axis direction.
In some embodiments, as shown in fig. 6 and 10, the second positioning assembly 23 further includes a second driving device 233, and the second driving device 233 drives the card pressing assembly 231 to move back and forth in a direction approaching or separating from the insertion slot 211. It can be understood that, by automatically driving the card pressing member 231 to approach or separate from the back surface of the reagent card 200 by the second driving device 233, the card pressing member 231 can be precisely and tightly fitted to the back surface of the reagent card 200, and the second positioning member 232 can be properly inserted into the card fixing hole on the back surface of the reagent card 200. It should be noted that the second driving device 233 is located outside the side plate 214 of the card insertion main body 21 opposite to the window, the card pressing component 231 is located in the insertion groove 211, and the second driving device 233 located outside the insertion groove 211 is inserted into the side plate 214 through a connecting rod to be connected with the card pressing component 231, so that the card pressing component 231 can move smoothly in the insertion groove 211 along the Y-axis direction of the reagent card 200, so as to adapt to the limited space in the insertion groove 211 and avoid mutual interference among the components. The second driving device 233 may be a device capable of driving the clamping unit 231 to move linearly, such as an electric cylinder or a servomotor screw structure, and is not particularly limited herein.
It should be noted that, a photoelectric stop block is further disposed on the card pressing assembly 231, a card pressing reset photoelectric switch and a card withdrawing self-locking photoelectric switch are disposed at a position of the card inserting main body 21 corresponding to a stroke range of the card pressing assembly 231, the card pressing reset photoelectric switch is located between the insertion groove 211 and the card withdrawing self-locking photoelectric switch, and when the card pressing assembly 231 moves to the photoelectric stop block and passes through the card pressing reset photoelectric switch, the second positioning element 232 of the card pressing assembly 231 is disengaged from the reagent card 200 at this time; the card pressing component 231 continues to move backwards, the photoelectric stop block moves to a position where the photoelectric stop block passes through the card withdrawing self-locking photoelectric switch, the card pressing component 231 stops moving, the elastic self-locking rod retreats to separate from the reagent card 200 at the moment, the elastic mounting part 223 resets, and the reagent card 200 moves upwards along the Z-axis direction to pop up.
In some embodiments, as shown in fig. 6 and 9, in order to enable the card pressing member 231 to reciprocate smoothly in a straight line in the output end operation direction of the second driving device 233, the second positioning member 23 further includes a straight guide 234, one end of the straight guide 234 is disposed on the card pressing member 231, and the other end is movably disposed on the card insertion body 21, so that the card pressing member 231 can move in a straight line in the output end movement direction of the second driving device 233. Specifically, in this embodiment, the linear guide 234 may include a linear bearing and a guide shaft, a guide hole is formed in the card insertion main body 21 along the moving direction of the output end of the second driving device 233, the linear bearing is vertically inserted into the guide hole, and one end of the guide shaft passes through the linear bearing and then is fixedly connected to the card pressing assembly 231. It can be appreciated that the guide shaft can slide within the linear bearing and ensure that the guide shaft can move linearly through the action of the linear bearing, thereby ensuring that the card pressing assembly 231 can move linearly.
In some embodiments, the end of the second positioning element 232 away from the card pressing element 231 is a convex arc structure or a slant structure; specifically, the second positioning member 232 may be a positioning pin. The end of the second positioning member 232 forms a convex arc structure or an inclined plane structure, so that the second positioning member 232 can be adaptively adjusted in the process of inserting the reagent card 200 into the card fixing hole, the second positioning member 232 can accurately and smoothly slide into the card fixing hole, and can slide out of the card fixing hole under the action of external force, and the reagent card positioning device has good mechanical in-place touch feeling.
In some embodiments, as shown in fig. 5 and 7, the card-insertion body 21 further has a slot communicating with the insertion slot 211, and the card-insertion device 2 further includes a cover assembly 24 movably connected to the card-insertion body 21, the cover assembly 24 being capable of moving to close or open the slot. It can be understood that, the notch of the card insertion main body 21 is used for inserting the reagent card 200, and the notch is specifically disposed at the top plate 213 of the card insertion main body 21, wherein when the reagent card 200 is not inserted into the notch, the cover assembly 24 covers the notch to enable the notch to be in a closed state, and when the notch needs to be inserted into the reagent card 200, the cover assembly 24 moves relative to the notch to open the notch, so that the reagent card 200 is inserted into the notch, and foreign matters such as dust can be effectively prevented from entering the insertion groove 211. In the present embodiment, the closing assembly 24 includes a rotating plate 241, a rotating shaft 242, a tension spring 244 and two mounting plates 243; the two mounting plates 243 are correspondingly arranged at the two opposite sides of the card inserting body 21 corresponding to the notches, the mounting plates 243 are provided with sliding grooves, two ends of the rotating shaft 242 are respectively arranged in the sliding grooves of the two mounting plates 243, the rotating plate 241 is rotatably arranged on the mounting plates 243 through the rotating shaft 242 and covers the notches, two ends of the tension spring 244 are respectively abutted against the rotating shaft 242 and the card inserting body 21, when the reagent card 200 is inserted into the inserting groove 211, the rotating plate 241 is driven to rotate along the sliding grooves towards the direction of the inserting groove 211, so that the notches are opened, the reagent card 200 is conveniently inserted, at the moment, the tension spring 244 is in a compression state, when the reagent card 200 is pulled out, the tension spring 244 drives the rotating plate 241 to reversely rotate along the sliding grooves in the process of recovering the self state, and finally the rotating plate 241 seals the notches, therefore, the rotating plate 241 can be in a closed state when no reagent card 200 is inserted through the rotating plate 241, the rotating shaft 242, the tension spring 244 and the two mounting plates 243, after being pulled out, the reagent card 200 can automatically reset, and foreign matters such as dust are effectively prevented from entering the inside of the inserting groove 211. In addition, an E-shaped clamp spring 245 is disposed at the end of the mounting plate 243 of the rotating shaft 242 to limit the axial movement of the rotating shaft 242 and prevent the tension spring 244 from being disengaged from the rotating shaft 242.
In some embodiments, as shown in fig. 9, the card pressing assembly 231 comprises a card pressing plate 2311 and a second heating device; the output end of the second driving device 233 is connected to the card pressing plate 2311, and the second heating device is disposed on one side of the card pressing plate 2311 facing the inserting groove 211. It can be understood that when the second driving device 233 drives the pressure-sensitive plate 2311 to move to extend into the back surface of the reagent card 200, the second heating device can heat the back surface of the reagent card 200, so as to satisfy the environmental temperature condition detected by the reagent card 200. Specifically, in the present embodiment, the second heating device includes a second heating film 2312 and a second heat-conducting plate 2313, the second heat-conducting plate 2313 is connected to one end of the card pressing plate 2311 away from the second driving device 233, and the second heating film 2312 is disposed on one side of the second heat-conducting plate 2313 close to the card pressing plate 2311. Specifically, in the embodiment, the second heating film 2312 is attached to the second heat conduction plate 2313, so that the heat of the second heating film 2312 can be sufficiently conducted to the second heat conduction plate 2313. It can be appreciated that the second heat conductive plate 2313 is used to form a bonded state with the reagent card 200 and to conduct heat of the second heating film 2312 to uniformly heat the reagent card 200.
In some embodiments, as shown in fig. 9, a side of the second heat conductive plate 2313 remote from the second heating film 2312 is provided with a first temperature sensing member 2314. It can be understood that, the temperature of the reagent card 200 is sensed in real time by the first temperature sensing part 2314, the heating temperature of the reagent card 200 can be accurately controlled, and the influence on the detection effect caused by the overhigh or overlow temperature of the reagent card 200 is effectively avoided.
In some embodiments, as shown in fig. 7, 11 and 13, the in-vitro diagnostic apparatus 100 further comprises a suction power source, the clamping plate 2311 further has at least one air inlet channel 2315, the air inlet channel 2315 has an air inlet end and an air outlet end, the air inlet end of the air inlet channel 2315 at least partially extends out of the clamping plate 2311 and faces the insertion groove 211, the end of the air inlet end extending out of the clamping plate 2311 is in a ring structure, the air inlet end is used for being in sealed communication with the air hole of the reagent card 200, and the air outlet end is in communication with the suction power source. The back surface of the reagent card 200 may be provided with a cover film layer 240, and the cover film layer 240 may cover air holes, card fixing holes, and the like of the reagent card 200. During operation, the annular structure of the air inlet channel 2315 abuts against the cover film of the reagent card 200 corresponding to the air hole, so that the cover film seals the air hole of the reagent card 200, an effective sealing environment is formed for the reagent card 200, the air tightness is good, the processing precision of the air inlet channel 2315 can be reduced, and the sealing performance of each air hole can be ensured by arranging the air inlet channels 2315 on the pressure card 2311 under the condition that the reagent card 200 needs to be subjected to porous sealing. Specifically, the suction power source may be a plunger pump 6, a peristaltic pump, or the like, and is not particularly limited herein.
It can be understood that the air suction power source communicates with the air holes of the reagent card 200 through the air inlet channel 2315, when the card pressing plate 2311 is attached to the reagent card 200, the air inlet channel 2315 on the card pressing plate 2311 is aligned with the air holes of the reagent card 200, and the air suction operation can be performed on the inside of the reagent card 200 by starting the air suction power source to form a negative pressure environment in the reagent card 200. It should be further noted that each flow channel 220 of the reagent card 200 is correspondingly provided with an air hole, and each air hole is correspondingly provided with an air inlet channel 2315, so that each flow channel 220 can be independently pumped by an air pumping power source, so that each flow channel 220 forms an independent negative pressure state according to the requirement of the detection item.
In some embodiments, the in vitro diagnostic apparatus 100 further comprises a valve island arrangement through which a source of suction power is controlled to communicate with the air intake channel 2315. Specifically, the valve island device comprises a valve island body, a negative pressure detection element and at least one first valve switch, wherein the valve island body is provided with at least one first gas channel, and the first gas channel and the air inlet channel 2315 are arranged in a one-to-one correspondence manner and are controlled and communicated through the first valve switch; the first gas channel is communicated with the air suction power source, and the negative pressure detection element is arranged in the first gas channel. It can be understood that, by controlling the air suction power source to communicate with the air inlet channel 2315 through the valve island device, the reagent card 200 can be independently air-sucked through the respective flow channels 220 by starting the air suction power source, and whether the air leakage condition exists can be sensed through the negative pressure detecting element.
In some embodiments, as shown in fig. 2 and 13, the source of suction power is a plunger pump 6. The pressing and clamping plate 2311 is further provided with an air suction channel 2318 used for being communicated with an air suction hole of the reagent card 200, the plunger pump 6 is communicated with the air suction channel 2318, when the pressing and clamping plate 2311 is attached to the reagent card 200, the air suction channel 2318 on the pressing and clamping plate 2311 is aligned with the air suction hole of the reagent card 200, and the air suction operation can be carried out on the reagent card 200 by starting the plunger pump 6 and the pressure discharge reset operation can be carried out on the plunger pump 6.
In some embodiments, as shown in fig. 12 and 13, the pressure card 2311 is further provided with at least one pressure detection hole 2319; the in-vitro diagnostic apparatus 100 further comprises a first pressure sensor 2316 and a sealing ring 2317, wherein the first pressure sensor 2316 is hermetically arranged in the pressure detection hole 2319 through the sealing ring 2317. Specifically, in the present embodiment, two sealing rings 2317 are provided, and the two sealing rings 2317 are tightly attached to the inverted conical surface of the first pressure sensor 2316, so that the sealing performance of the first pressure sensor 2316 in the pressure detection hole 2319 can be realized, and the pressure condition in the reagent card 200 can be detected by the first pressure sensor 2316.
In some embodiments, as shown in fig. 14 to 21, the pressure valve device 1 further comprises a pressure valve body 11 and at least one first actuating device 16; the pressure valve body 11 is at least partially disposed in the insertion groove 211. The pressure valve body 11 is movably connected with the pressure valve piece 12; specifically, in this embodiment, the pressure valve body 11 is correspondingly disposed at the window position of the insertion groove 211, so that the pressure valve member 12 can extend into the insertion groove 211 to abut against the flow channel hole 230 of the reagent card 200. The first driving devices 16 are disposed corresponding to the valve pressing members 12, and each of the first driving devices 16 can drive one of the valve pressing members 12 to move relative to the valve pressing body 11 to extend into the insertion groove 211. It can be understood that, each pressure valve 12 can be controlled by one first driving device 16, and therefore, the pressure valve 12 and the flow passage holes 230 can be arranged in a one-to-one correspondence manner, so that the flow passage hole 230 of each flow passage 220 can be controlled to be opened or disconnected by one pressure valve 12, different pressure valve 12 can be controlled by different first driving devices 16 to block different flow passages 220, thereby accurately controlling the opening or the disconnection of each flow passage 220, effectively avoiding reagent leakage in the disconnected flow passage 220, and effectively avoiding the influence on the detection efficiency and the detection effect. Specifically, the first driving device 16 may be a device capable of driving the valve member 12 to move linearly, such as an electric cylinder or a linear motor, and is not particularly limited herein. Specifically, the first driving device 16 may be a device capable of driving the valve member 12 to move linearly, such as an electric cylinder or a linear motor, and is not particularly limited herein.
In some embodiments, as shown in fig. 14, the output end of the first actuating device 16 is at least partially disposed opposite the valve member 12, and the output end of the first actuating device 16 is movable to press against the valve member 12. It should be noted that the output end of the first driving device 16 may be only partially configured to be disposed opposite the end of the pressure valve member 12, or the output end of the first driving device 16 may be entirely disposed opposite the end of the pressure valve member 12. It can be understood that, the output end of the first driving device 16 and the pressure valve element 12 are arranged independently, and at least part of the output end of the first driving device 16 is arranged opposite to the pressure valve element 12, so that the first driving device 16 can move towards one end close to the pressure valve element 12 through its output end after being started and press against the pressure valve element 12, so as to drive the pressure valve element 12 to move relative to the pressure valve body 11 to extend out of the pressure valve body 11, and at this time, the other end face of the pressure valve element 12 far away from the first driving device 16 can press the covering film 240 on the reagent card 200. Therefore, at least part of the output end of the first driving device 16 is arranged opposite to the pressure valve 12, so that the pressure valve 12 can be driven to move to disconnect the flow channel 220 through the first driving device 16, the output end of the first driving device 16 is in surface-to-surface contact with the pressure valve 12, the output end of the first driving device 16 and the pressure valve 12 do not need to be precisely aligned and coaxially arranged, the position precision requirement and the processing precision requirement are reduced, and the phenomenon that each first driving device 16 is jammed during working can be effectively avoided.
In some embodiments, as shown in fig. 14, 20 and 21, the pressure valve device 1 may be provided with driving holders 17, each array of the first driving devices 16 is disposed on the driving holders 17, and the output end of the first driving device 16 may be provided with a driving ram 18, and specifically, the end of the driving ram 18 may movably abut against the pressure valve member 12, so as to increase the corresponding areas of the first driving device 16 and the pressure valve member 12. Specifically, in this embodiment, when the first driving device 16, such as a linear motor, is assembled, the linear motor is installed in the driving fixing seat 17 from top to bottom, the roller in the driving fixing seat 17 is reset by the spring, so that the linear motor is pressed forward, and the driving ram 18 is installed at the output shaft end of the linear motor from front to back, so that each group of linear motors and the driving ram 18 can be ensured to be in the same assembly state, and the assembly at the later stage is facilitated; still be provided with opto-coupler sensor 171 on the drive fixing base 17 to make drive pressure head 18 and opto-coupler sensor 171 be in parallel state, so, press the linear electric motor on the valve device 1 to correspond the setting according to pressing valve member 12, each linear electric motor can realize independent control, detects initial position through opto-coupler sensor 171, and the accurate motion of control linear electric motor step number realization motor.
In some embodiments, as shown in fig. 4 and 15, the pressure valve device 1 further comprises a first elastic member 13; the valve pressing member 12 is provided with a stopper 121, the first elastic member 13 is provided between the stopper 121 and the valve pressing body 11, and the force of the first elastic member 13 acting on the valve pressing member 12 is opposite to the force of the first driving means 16. It can be understood that, after the first driving device 16 drives the pressure valve member 12 to extend relative to the pressure valve body 11 to complete the operation of extruding the covering film layer 240 of the reagent card 200, the first driving device 16 moves in a reverse direction to release the output end of the pressure valve member 12 from the pressure valve member 12, at this time, the pressure valve member 12 retracts in a reverse direction relative to the pressure valve body 11 under the action of the first elastic member 13 to restore to the original position, the pressure valve member 12 leaves the covering film layer 240 of the reagent card 200, and the covering film layer 240 restores to the original state to enable the blocked flow channel 220 to form a communication state. Therefore, the first driving device 16 and the first elastic member 13 are matched to control the pressure valve member 12, so that the pressure valve member 12 can smoothly reciprocate to quickly control the opening or the disconnection of the flow channel 220 of the reagent card 200, and the reagent card has the characteristics of simple structure and convenience in control.
In some embodiments, as shown in fig. 15, the pressure valve member 12 is provided with an annular blocking member 121 along the circumferential direction thereof, the first elastic member 13 is sleeved on the pressure valve member 12, and opposite ends of the first elastic member 13 abut against the blocking member 121 and the pressure valve body 11, respectively. It can be understood that, the first elastic element 13 is sleeved on the pressure valve element 12 and abuts between the blocking element 121 and the pressure valve body 11, on one hand, the compactness of the structure can be improved, and on the other hand, the first elastic element 13 can also reduce the impact force of the pressure valve element 12 on the covering film layer 240, thereby effectively preventing the covering film layer 240 from being punctured, and improving the service life of the first driving device 16. In the present embodiment, the first elastic element 13 may be a spring or other element with elastic property, and is not limited herein.
In some embodiments, as shown in fig. 14, the pressure valve body 11 is provided with at least one through connection hole 113, and the connection holes 113 are arranged in the pressure valve body 11 in an array structure; the connection holes 113 are provided in one-to-one correspondence with the pressure valve members 12, and the pressure valve members 12 are movably inserted into the connection holes 113. It can be understood that, in this embodiment, through pressing the connecting hole 113 that valve member 12 activity wore to locate and press valve body 11, connecting hole 113 can form guide effect to pressing valve member 12, thereby can make pressing valve member 12 carry out orientation and sharp reciprocating motion along connecting hole 113 under the drive of first drive arrangement 16 and first elastic component 13, in order to effectively avoid pressing valve member 12 to press valve body 11 reverse retraction in order to resume position time position relative to the position to take place great skew, thereby can avoid pressing valve member 12 and the output of first drive arrangement 16 to take place the skew and influence the drive effect, so that press valve member 12 can accurate motion to correspond with runner hole 230 of reagent card 200.
Specifically, in this embodiment, as shown in fig. 15, the pressure valve body 11 includes a valve body 111 and a valve cover 112, the valve cover 112 covers the valve body 111 to form a cavity, the valve cover 112 and the valve body 111 are both provided with the connection hole 113, the pressure valve 12 is inserted into the cavity through the connection hole 113, wherein the blocking member 121 of the pressure valve 12 is received in the cavity, the first elastic member 13 is also disposed in the cavity and sleeved on the pressure valve 12, the first driving device 16 is disposed at an end of the pressure valve 12 close to the valve body 111, and the reagent card 200 is disposed at an end of the pressure valve 12 close to the valve cover 112, so that the first driving device 16 and the first elastic member 13 cooperate to drive the end of the pressure valve 12 to extend out of the valve cover 112 to press the covering film 240 of the reagent card 200, or to retract the pressure valve 12 into the cavity to leave the covering film 240 of the reagent card 200. Further, it should be noted that the radial area of the stopper 121 is larger than the radial area of the connecting hole 113, so as to prevent the pressure valve member 12 from coming off the pressure valve body 11 through the connecting hole 113.
In some embodiments, as shown in fig. 14, at least one sensing element 14 is further disposed at one end of the pressure valve body 11 close to the insertion groove 211, and the sensing element 14 is embedded in the pressure valve body 11. It can be understood that, by arranging the sensing element 14 at one end of the pressure valve body 11 close to the insertion groove 211, the sensing element 14 can sense the flowing state and flow rate of the liquid in the flow channel 220 of the reagent card 200, thereby realizing the state detection and accurate quantification of the liquid in each flow channel 220 of the reagent card 200. Specifically, in the present embodiment, the sensing element 14 may be a liquid level sensor, and of course, in other embodiments, the sensing element 14 may also be other elements capable of sensing the state and accurate quantitative amount of the liquid in each flow channel 220, which is not limited herein.
In some embodiments, as shown in fig. 15 and 17, the pressure valve device 1 further comprises a first heating device 15; the first heating device 15 includes a first heating film 151 and a first heat-conducting plate 152, the first heat-conducting plate 152 is connected with the one end that presses the valve body 11 to be close to the inserting groove 211, and the first heating film 151 is disposed on the one side that the first heat-conducting plate 152 is close to the valve body 11. Specifically, in the present embodiment, the first heating film 151 is attached to the first heat conducting plate 152, so that the heat of the first heating film 151 can be sufficiently conducted to the first heat conducting plate 152. As can be appreciated, the first heat conductive plate 152 is used to form a coupled state with the reagent card 200 and to conduct heat of the first heating film 151 to uniformly heat the reagent card 200; note that the first heat conduction plate 152 has a step at an edge thereof. Further, the first heat conduction plate 152 is used for being attached to the front surface of the reagent card 200, and the second heat conduction plate 2313 of the card pressing assembly 231 is used for being attached to the back surface of the reagent card 200, so that the first heating film 151 of the pressure valve device 1 and the second heating film 2312 of the card inserting device 2 are matched to be disposed on the front surface and the back surface of the reagent card 200, so that the whole reagent card 200 can be uniformly heated. Specifically, the pressure valve body 11 may be provided with a second temperature sensing member 157 for sensing the heating temperature of the first heating film 151 in real time.
In some embodiments, as shown in fig. 4, 15 and 17, the first heating device 15 further comprises a floating connection 153; the first heat conduction plate 152 is floatingly mounted on the pressure valve body 11 in the movable extending direction of the pressure valve member 12 by the floating connection member 153. It is understood that the first heat conduction plate 152 is mounted on the pressure valve body 11 through the floating connection member 153 so that the first heat conduction plate 152 has floating performance with respect to the pressure valve body 11, and the first heat conduction plate 152 can move with respect to the pressure valve body 11 in the movable extending direction of the pressure valve member 12. After the pressure valve device 1 is assembled to the card insertion device 2, the first heat conduction plate 152 can keep the first heat conduction plate 152 and the reagent card 200 in a bonding state during operation through the floating performance of the first heat conduction plate 152, so that the heating efficiency is ensured. Specifically, in this embodiment, the edge of the first heat conducting plate 152 has a step, the step of the first heat conducting plate 152 abuts against the edge of the window of the card inserting main body 21 located in the inserting groove 211, the middle portion of the first heat conducting plate 152 extends into the window of the inserting groove 211, after the reagent card 200 is preliminarily positioned by the first positioning component 22, the reagent card 200 can only move in the Y direction, and then the card pressing component 231 extends out to insert the second positioning component 232 into the card positioning hole of the reagent card 200, so as to drive the reagent card 200 to press the first positioning component 221 and move towards the first heat conducting plate 152, so that the reagent card 200 presses the first heat conducting plate 152, the floating performance of the first heat conducting plate 152 can adapt to the moving distance of the reagent card 200, so that the first heat conducting plate 152 and the second heat conducting plate 2313 can both maintain the bonding state with the reagent card 200 during the operation, thereby ensuring the heating efficiency.
In some embodiments, as shown in fig. 15 and 17, one end of the pressure valve body 11 close to the insertion groove 211 is provided with the cavity recessed along the movable extending direction of the pressure valve member 12; the floating connection member 153 includes a connection post 154, a position-limiting portion 155 and an elastic portion 156; the connecting column 154 is vertically arranged in the cavity, a via hole is formed in the first heat conducting plate 152, the first heat conducting plate 152 is movably sleeved on the position, between the bottom wall of the cavity and the limiting part 155, of the connecting column 154, and an elastic part 156 is further arranged at the position, between the bottom wall of the cavity and the limiting part 155, of the connecting column 154 and used for enabling the first heat conducting plate 152 after moving to recover to the original position. It is understood that the first heat-conducting plate 152 is disposed in the cavity by the coupling posts 154 and the elastic portions 156, and the first heat-conducting plate 152 at least partially extends out of the cavity, so that the first heat-conducting plate 152 can adapt to the secondary positioning operation of the card pressing assembly 231 according to its own floating performance, so that the first heat-conducting plate 152 and the second heat-conducting plate 2313 are closely attached to the front and back surfaces of the reagent card 200.
In some embodiments, as shown in fig. 15, 18 and 19, the in vitro diagnostic apparatus 100 further comprises a stirring device 3 connected to the pressure valve device 1; the stirring device 3 comprises a power assembly and an acting element 34, wherein the power assembly can drive the acting element 34 to move, when the acting element 34 moves, a driving force for covering at least a partial area of the insertion groove 211 can be formed, and the driving force is used for driving a driven element positioned in the covered area to move. It should be noted that the acting element 34 can drive the driven element to move by the driving force formed by itself, wherein the driven element may not contact with the acting element 34, that is, the driven element only needs to be located in the coverage area of the driving force of the acting element 34, the driving force of the acting element 34 can drive the driven element located in the coverage area, so that the driven element can be placed inside the object to be stirred, and the stirring operation is performed by the driving of the external acting element 34. Specifically in this embodiment, the driven piece is packaged in reagent chamber 210 of reagent card 200, treat that it flows into reagent chamber 210 back to detect sample and reagent through runner 220, power component drives action piece 34 motion, because action piece 34 can form the drive power that has the coverage area, can drive the driven piece that is located reagent chamber 210 through the drive power of self in the action piece 34 motion process and move and form the stirring function, action piece 34 need not to stretch into in the reagent chamber 210 and can treat and detect sample and reagent and mix the stirring, consequently can the rational utilization space form the stirring function, and has simple structure, stirring effect is good, stir efficient characteristics.
In some embodiments, the power assembly includes a rotating device 31, a conversion assembly 32, and a moveable member 33; the output end of the rotating device 31 is connected with the conversion component 32, the movable piece 33 is connected with the conversion component 32, and the rotating device 31 drives the movable piece 33 to reciprocate along the linear direction through the conversion component 32; an acting member 34 is provided on the movable member 33. It can be understood that, by connecting the conversion component 32 to the rotating device 31 and the moving element 33 respectively, the conversion component 32 can convert the rotating motion of the rotating device 31 into a linear motion, so as to drive the moving element 33 to form a linear reciprocating motion, and therefore, the rotating device 31 can only provide a unidirectional rotating motion to enable the moving element 33 to form a linear reciprocating motion, and the rotating device 31 does not need to be switched between forward rotation and reverse rotation repeatedly, thereby prolonging the service life of the rotating device 31.
In some embodiments, as shown in fig. 19, the conversion assembly 32 includes a cam 321 and a guide assembly 322; the output end of the rotating device 31 is connected with the cam 321, the movable member 33 is engaged with the cam 321, the movable member 33 is movably disposed on the guide component 322, and the rotating device 31 can drive the movable member 33 to linearly move along the guide component 322 when driving the cam 321 to rotate; it should be noted that, during the rotation of the cam 321 driven by the rotating device 31, the movable element 33 is always engaged with the cam 321. It can be understood that, since the cam 321 has a convex angle, the rotating device 31 drives the cam 321 to rotate, so as to drive the movable element 33 engaged with the cam 321 to move, and the movable element 33 can move linearly along the guide element 322 under the engagement transmission of the cam 321 and the guidance of the guide element 322, so that the rotating motion of the rotating device 31 can form the linear motion of the movable element 33 through the cooperation of the cam 321 and the guide element 322, and the structure is simple. In addition, in other embodiments, the conversion component 32 may also drive the movable component 33 to move linearly through other components, for example, a groove extending along the extending direction of the guide component 322 is formed on the conversion component 32, and the movable component 33 forms a linear motion along the groove and the guide component 322 under the guidance of the guide component 322, which is not limited herein.
In some embodiments, the conversion component 32 further includes a second elastic component 323, the movable component 33 is connected with the guide component 322 through the second elastic component 323, and the movable component 33 is always engaged with the cam 321 to drive under the action of the second elastic component 323. Specifically, a first end of the movable member 33 is engaged with the cam 321, and a second end of the movable member 33 is connected to the guide element 322 through the second elastic element 323. It can be understood that when the lobe of the cam 321 gradually rotates away from the movable element 33, the movable element 33 always engages with the cam 321 during the rotation of the cam 321 by the acting force of the second elastic element 323, and the movable element 33 is driven by the acting force of the second elastic element 323 to move along the guide element 322 following the rotation of the cam 321. Therefore, the cam 321 and the movable member 33 can always be in a state of abutting and meshing by the action of the second elastic member 323, and the influence of the gap between the cam 321 and the movable member 33 on the transmission effect is avoided.
In some embodiments, as shown in fig. 19, the guide assembly 322 includes a guide 3221 and a slider 3222; the guide member 3221 is disposed along a moving direction of the movable member 33, the movable member 33 is disposed on the sliding member 3222, and the sliding member 3222 is slidably disposed on the guide member 3221; specifically, in this embodiment, the guiding element 3221 may be a guiding shaft, the sliding element 3222 may be a bearing, the bearing is movably sleeved on the guiding shaft, the moving element 33 is disposed on the bearing, the moving element 33 is slidably disposed on the guiding shaft through the bearing, and the bearing can improve wear resistance and prolong service life. As can be understood, the guide member 3221 and the slider 3222 are slidably engaged with each other, so that the movable element 33 can smoothly slide back and forth along the direction of the guide member 3221, and the smoothness and linearity of the movement of the movable element 33 are improved. Of course, in other embodiments, the guiding element 322 may be other components capable of guiding the linear motion of the movable element 33, such as a linear sliding platform, and the like, and is not limited herein.
In some embodiments, the moveable member 33 is provided with a driven wheel 35, and the moveable member 33 is provided with the driven wheel 35 engaging with the cam 321. In this embodiment, the driven wheel 35 may be a bearing, and the movable element 33 is engaged with the cam 321 through the bearing, so that the bearing can improve wear resistance and prolong service life. It can be understood that the movable member 33 is disposed by engaging the driven wheel 35 with the cam 321, so that the position accuracy between the movable member 33 and the cam 321 can be reduced, and the movable member 33 can be rotated by the cam 321 without aligning the movable member 33 with the cam 321. In addition, it should be noted that the first end of the movable element 33 may also be directly provided with an arc-shaped or semicircular structure, so as to form an engagement transmission structure with the cam 321 directly through the movable element 33.
In some embodiments, the acting element 34 is a magnetic element capable of generating a magnetic attraction or repulsion that attracts or repels the driven element, and the magnetic attraction or repulsion is a driving force. The passive member may be a magnet or a magnetic member having magnetism that can form a magnetic attraction force or a magnetic repulsion force with the magnetic member. It can be understood that the passive component having magnetism or capable of being magnetized is disposed inside the object to be stirred, such as the reagent chamber 210 enclosed in the reagent card 200, and the passive component can be driven to move by the acting component 34 having magnetism during the moving process, so as to effectively stir the sample to be detected and the reagent in the reagent chamber 210. It should be noted that the acting element 34 may also drive the driven element to move through other acting manners, and is not limited herein.
In some embodiments, there are at least two magnetic members, each magnetic member having the same magnetism and being spaced apart from each other along the extension of the moving direction of the movable member 33. The magnetic parts are arranged, the magnetic parts are matched to form a large action range, the driving force and the coverage range for driving the driven part can be increased, and the driven part in the packaging state can be driven to move through the magnetic parts.
In some embodiments, as shown in fig. 19, the stirring device 3 further includes a mounting seat 36, the rotating device 31, the converting assembly 32, the movable member 33 and the acting element 34 are all disposed on the mounting seat 36, the mounting seat 36 is disposed on the pressure valve body 11, wherein the rotating device 31 is disposed on one side of the pressure valve body 11 away from the insertion slot 211, a clearance hole is opened on the pressure valve body 11, and the acting element 34 is inserted into the clearance hole and can reciprocate in the clearance hole, so that the driving force formed by the acting element 34 is not interfered by the pressure valve body 11. It can be understood that, by integrating the rotating device 31, the converting component 32, the moving component 33 and the acting component 34 on the mounting seat 36, the structure compactness of the stirring device 3 can be improved, so that the components are integrated into a whole for convenient installation and assembly. In addition, in the present embodiment, the rotating device 31 is disposed along the Y direction, and the movable element 33 is disposed along the X direction, so that the structural integration can be further improved, and the structural space can be saved.
In some embodiments, as shown in fig. 5 and 6, the docking bay 211 includes a first slot 2111 and a second slot 2112 in communication with each other; the in-vitro diagnostic apparatus 100 further includes an identification module 25 and a reading module 26 disposed on the card insertion device 2, wherein the identification module 25 is used for identifying the insertion status of the first slot 2111, and the reading module 26 is used for reading the information of the reagent card 200 inserted into the second slot 2112. The first slot 2111 is used for inserting a blood collection tube 300, the second slot 2112 is used for inserting a reagent card 200, the reagent card 200 is provided with a plurality of flow channels 220, and the first slot 2111 and the second slot 2112 in a communicating state can communicate the blood collection tube 300 inserted into the first slot 2111 with the flow channel 220 of the reagent card 200 inserted into the second slot 2112, so that a blood sample of the blood collection tube 300 can flow into the flow channel 220 of the reagent card 200 to perform blood sample detection. It can be understood that, by setting the identification module 25 and the reading module 26 on the card insertion body 21, the specific position of the blood collection tube 300 inserted into the first slot 2111 can be identified by the identification module 25, so that the communication state of the blood collection tube 300 and the corresponding flow channel 220 of the reagent card 200 can be automatically obtained, the corresponding flow channel 220 is controlled to perform the detection operation, meanwhile, the information of the reagent card 200 is read by the reading module 26, the specific type and other related information of the reagent card 200 can be obtained, the problems of errors occurring at the position where the blood sample enters the flow channel 220 and errors of the information of the reagent card 200 can be effectively avoided, and the detection effect and the detection process are effectively prevented from being influenced.
In some embodiments, the card insertion main body 21 is vertically provided with a first slot 2111 and a second slot 2112, and the slot, the first slot 2111 and the second slot 2112 are sequentially communicated, where the first slot 2111 and the second slot 2112 may be an integrated slot structure, and are distinguished only according to different insertion objects, or the first slot 2111 and the second slot 2112 may also be a split slot structure, which is not limited herein. The identification module 25 is disposed at a position of the card insertion body 21 corresponding to the first slot 2111, and the reading module 26 is disposed at a position of the card insertion body 21 corresponding to the first slot 2111 or the second slot 2112. Specifically, in this embodiment, the reagent card 200 can be connected by a blood tube rack 310, wherein the blood tube rack 310 is provided with a plurality of insertion tubes 320 respectively communicated with the flow channels 220 of the reagent card 200, and each insertion tube 320 is used for inserting a blood collection tube 300; when detection is needed, the reagent card 200 is inserted into the second slot 2112 through the notch, the blood vessel holder 310 is inserted into the first slot 2111, the blood collection tube 300 is inserted into the insertion tube 320, and a blood sample of the blood collection tube 300 can enter the flow channel 220 of the reagent card 200 through the insertion tube 320, so that the blood collection tube 300 can be stably inserted into the preset position of the first slot 2111 through the blood vessel holder 310, and the insertion of the reagent card 200 is not interfered, and the conduction operation between the inserted blood collection tube 300 and the reagent card 200 is not influenced. In which the type information of the reagent card 200 can be provided in the reagent card 200 or in the blood vessel holder 310, it is possible to read the information of the reagent card 200 inserted into the second slot 2112 by providing the reading module 26 in a position of the insertion card main body 21 corresponding to the first slot 2111 or the second slot 2112.
In some embodiments, as shown in fig. 5, the identification module 25 includes an infrared radiation module 251 and an infrared reception module 252 disposed on the card insertion device 2, and the infrared radiation module 251 and the infrared reception module 252 are located at two opposite sides of the first slot 2111. It should be noted that, in this embodiment, the blood vessel frame 310 is provided with a plurality of insertion pipes 320 respectively communicated with the flow channels 220 of the reagent cards 200, and the wall of the blood vessel frame 310 corresponding to each insertion pipe 320 is provided with two opposite through holes, the infrared radiation module 251 and the infrared receiving module 252 are provided corresponding to the through holes, so that when the blood vessel frame 310 is not inserted with the blood sampling tube 300, the infrared rays emitted from the infrared radiation module 251 can pass through the through holes and then be received by the infrared receiving module 252, when the blood vessel frame 310 is inserted with the blood sampling tube 300, the infrared rays emitted from the infrared radiation module 251 are shielded by the blood sampling tube 300, at this time, the infrared receiving module 252 cannot receive the infrared rays emitted from the infrared radiation module 251, and therefore, whether the blood sampling tube 300 is inserted into the first slot 2111 in place or not can be determined through the information received by the infrared receiving module 252, and the specific position of the blood sampling tube 300 inserted into the first slot 2111, therefore, the communication between the blood collection tube 300 and the flow channel 220 of the reagent card 200 can be accurately obtained, so as to control the corresponding flow channel 220 to perform the detection operation.
In some embodiments, as shown in fig. 5, the identification module 25 is provided in a plurality, and each identification module 25 is spaced along the length direction of the first slot 2111. A plurality of identification modules 25 are provided, a plurality of identification modules 251 are provided corresponding to the infrared radiation modules 251, the infrared radiation modules 251 are provided at intervals along the longitudinal direction of the first slot 2111, a plurality of infrared reception modules 252 are provided, and the infrared reception modules 252 and the infrared radiation modules 251 are provided in one-to-one correspondence. Understandably, the plurality of infrared radiation modules 251 and the plurality of infrared reception modules 252 cooperate to form a plurality of identification modules 25, which can identify the blood collection tubes 300 inserted into the first slot 2111 at various positions; specifically, in this embodiment, a plurality of insertion tubes 320 are disposed on the blood vessel frame 310, each insertion tube 320 corresponds to one infrared radiation module 251 and one infrared receiving module 252, so as to identify whether the corresponding insertion tube 320 is inserted into the blood collection tube 300 in real time according to the corresponding identification module 25, thereby effectively and timely identifying the condition that each insertion tube 320 is inserted into the blood collection tube 300, and avoiding omission.
In some embodiments, as shown in fig. 5, the read module 26 includes an NFC read module located on one side of the first slot 2111 or the second slot 2112 and configured to identify the NFC tag of the reagent card 200 inserted into the second slot 2112. It can be understood that when the reagent card 200 is inserted into the second slot 2112, the NFC tag is driven to approach the NFC reading module, and when the NFC tag reaches the reading area of the NFC reading module, the NFC reading module can quickly and accurately read the NFC tag and feed back the NFC tag to the control system, so that the relevant information such as the type of the reagent card 200 inserted into the second slot 2112 can be quickly identified. Therefore, the NFC reading module can read the NFC tag of the reagent card 200 inserted into the second slot 2112 in a close range, and has the characteristics of close distance, high bandwidth, low energy consumption and high security. In other embodiments, the reading module 26 may also read information of the reagent card 200 by using a reading technology such as RFID, and is not particularly limited herein.
In some embodiments, as shown in fig. 5, the card insertion device 2 is provided with an indication device for indicating the insertion state of the first slot 2111. It can be understood that the indicating device can indicate the position of the blood collection tube 300 inserted into any one of the insertion tubes 320 through the display mode or the trigger mode, so that the operator can insert the blood collection tube 300 into the specified insertion tube 320 of the first slot 2111 quickly and accurately according to the indication, and errors can be prevented. Specifically, in this embodiment, the indicating device includes a plurality of status indicating lamps 27, and the status indicating lamps 27 are disposed in one-to-one correspondence with the identification modules 25. It can be understood that, the status indicator lamp 27 corresponding to the flow channel 220 to be detected changes, and the corresponding blood collection tube 300 is inserted into the insertion pipeline 320 corresponding to the blood vessel frame 310 to communicate with the corresponding flow channel 220 of the reagent card 200, so that an operator can accurately insert the blood collection tube 300 into the specified insertion pipeline 320, and intuitively and quickly obtain the condition that the specific flow channel 220 of the reagent card 200 flows into the blood sample, thereby effectively avoiding the occurrence of errors.
In some embodiments, as shown in fig. 22 to 25, the in-vitro diagnostic apparatus 100 further includes an air supply device 4, the air supply device 4 includes a tank 41 and an air path system 42, the tank 41 has a first cavity 411 and a second cavity 412, the second cavity 412 is controlled by the air path system 42 to communicate with the first cavity 411 and enable air to enter the first cavity 411 from the second cavity 412, and the first cavity 411 is used for communicating with the flow channel 220 of the reagent card 200 for supplying air. In this embodiment, the pressure in the second chamber 412 of the can 41 is higher than the pressure in the first chamber 411 of the can 41, and the pressure in the first chamber 411 of the can 41 is constant to form a constant pressure chamber; it should be noted that the first chamber 411 forming a constant pressure chamber means that the pressure output value in the first chamber 411 is kept substantially constant, but small fluctuation of the output value is allowed within the error tolerance range of the instrument, specifically, the pressure values in the first chamber 411 and the second chamber 412 can be set within the range (<4500PA) in a self-defined manner, in one embodiment, the pressure value in the second chamber 412 is 2600PA, and the pressure value in the first chamber 411 is (1300 ± 10 PA). It can be understood that, when the air supply device 4 is used to supply air to the flow channel 220 of the reagent card 200, the second chamber 412 controls the air supply system 42 to supplement air pressure to the first chamber 411 so as to maintain a dynamic constant pressure state in the first chamber 411, and a constant pressure can be applied to the blood sample through the first chamber 411 to perform the detection of the phase transition process of the blood sample.
In some embodiments, the first chamber 411 is also in controlled communication with the flow channel 220 of the reagent card 200 via a valve island arrangement; the valve island device further comprises a second valve switch, the valve island body is provided with at least one second gas channel, the second gas channel and the flow channel 220 of the reagent card 200 are arranged in a one-to-one correspondence mode and are communicated in a control mode through the second valve switch, and the second gas channel is communicated with the first cavity 411. It can be understood that the control of the first cavity 411 to communicate with the flow channel 220 through the valve island device can perform independent pressurization operations on each flow channel 220 of the reagent card 200, and can sense the pressure state in the flow channel 220 through the first pressure sensor 2316. As can be seen from the above, the valve island device can independently control operations such as air suction, air intake, and air admission of the reagent card 200 by integrating a plurality of gas channels and valve switching members, has a fast response speed, does not affect each other, and has a compact structure.
In some embodiments, as shown in fig. 24, the volume of the first chamber 411 is larger than that of the second chamber 412, so that the first chamber 411 of the tank 41 can be supplemented with pressure through the second chamber 412, and the first chamber 411 has a larger spatial buffer pressure, so that the fluctuation in the first chamber 411 in the processes of air inlet and air outlet is smaller, and a stable constant pressure state is formed. Therefore, the air source device 4 has the characteristics of simple and compact structure and good constant pressure performance.
In some embodiments, the ratio of the volume of the first chamber 411 to the volume of the second chamber 412 is in the range of 2-4: 1. Specifically, the ratio of the volume of the first chamber 411 to the volume of the second chamber 412 may range from (2:1), 2.5:1, 3:1, 3.5:1, 4:1, etc., and is not particularly limited herein. It can be understood that the volume ratio of the first chamber 411 to the second chamber 412 can ensure that the first chamber 411 is at a better constant pressure stability within this range, and can be quickly adjusted to a preset pressure value when the first chamber 411 is at a pressure value lower or higher than the preset pressure value, so as to reduce the pressure fluctuation of the first chamber 411.
In some embodiments, as shown in fig. 23, the position of the can 41 corresponding to the first chamber 411 has a first open end 413, and the position of the can 41 corresponding to the second chamber 412 has a second open end 414; the gas supply means 4 further comprises a first end cap 415 and a second end cap 416; the first end cap 415 is sealingly attached to the canister 41 at a location corresponding to the first open end 413 and the second end cap 416 is sealingly attached to the canister 41 at a location corresponding to the second open end 414. It should be noted that, in this embodiment, the tank 41 includes four connecting plates and partitions, the four connecting plates surround to form the tank 41 having open ends at left and right ends, the partitions are vertically inserted into the tank 41 to partition the tank 41 into a first cavity 411 and a second cavity 412, the open end corresponding to the left side of the tank 41 is the above-mentioned first open end 413, the open end corresponding to the right side of the tank 41 is the above-mentioned second open end 414, the first open end 413 is hermetically connected by a first end cap 415, so that the first end cap 415, the four connecting plates, and the partitions cooperate to form the first cavity 411 in a sealed state, and the second end cap 416, the four connecting plates, and the partitions cooperate to form the second cavity 412 in a sealed state. Therefore, the first end cover 415 and the second end cover 416 are matched with each other, so that the first sealed cavity 411 and the second sealed cavity 412 can be formed on the one hand, and the non-integrated sealing structure of the tank 41 can facilitate assembly of all parts of the air source device 4, reduce assembly difficulty and facilitate disassembly, assembly and maintenance. Of course, in other embodiments, the tank 41 may be an integrated sealing structure, and is not limited herein.
In some embodiments, as shown in fig. 23, the air source device 4 further includes a first sealing member 417, a first annular groove 4151 adapted to the first open end 413 is formed on a side of the first end cap 415 close to the tank 41, and the first open end 413 is sealingly inserted into the first annular groove 4151 through the first sealing member 417; and/or the gas source device 4 further comprises a second sealing member 418, a second annular groove adapted to the second open end 414 is formed in one side of the second end cover 416 close to the tank 41, and the second open end 414 is hermetically inserted into the second annular groove through the second sealing member 418. As can be understood, the first open end 413 of the can 41 is connected to the first annular groove 4151 of the first end cap 415 in a sealing manner through the first sealing member 417, and the second open end 414 is connected to the second annular groove of the second end cap 416 in a sealing manner through the second sealing member 418, so that the distance between the first end cap 415 and the second end cap 416 and the can 41 can be controlled by size, the compression range of the first sealing member 417 and the second sealing member 418 can be effectively ensured to be about 20%, the assembly difficulty can be effectively reduced, and good air tightness can be ensured.
In some embodiments, the canister 41 is a plastic canister. In this embodiment, the tank 41 may be made of plastic materials such as polyoxymethylene resin and polyamide fiber, and the influence of the ambient temperature on the pressure values in the first chamber 411 and the second chamber 412 of the tank 41 can be effectively avoided.
In some embodiments, as shown in fig. 22 and 25, pneumatic system 42 includes a main pneumatic circuit 421, a branch pneumatic circuit 422, and a check valve 423; first chamber 411 and second chamber 412 are respectively through the external gas generator of main gas circuit 421 pressure boost, and first chamber 411 and second chamber 412 are through dividing gas circuit 422 intercommunication, and check valve 423 sets up on dividing gas circuit 422 so that gas can get into first chamber 411 from second chamber 412. It can be understood that, the first chamber 411 and the second chamber 412 may be respectively externally connected with an air supply device through a main air path 421, when the air supply device 4 is just started to perform an initial air intake process, the first chamber 411 and the second chamber 412 may both be rapidly pressurized to an air pressure range near a preset value through the main air path 421, then the opening of the air distribution path 422 is controlled by the check valve 423, the second chamber 412 supplies air and supplements pressure to the first chamber 411 through the air distribution path 422 to maintain a dynamic constant pressure state in the first chamber 411, and the second chamber 412 supplements pressure through the main air path 421. Therefore, the first cavity 411 is pressurized rapidly through the external air supply device of the main air passage 421, and the first cavity 411 is pressurized by being communicated with the second cavity 412 through the air passage 422, so that the first cavity 411 can be pressurized rapidly to a preset constant pressure state, and can be in a dynamic constant pressure state for a long time, and the constant pressure stability of the first cavity 411 is improved.
In some embodiments, as shown in fig. 25, pneumatic circuit 42 further includes a first pressure relief pneumatic circuit 424, a first switching valve 425, and a first speed valve 426; the first chamber 411 is controlled to communicate with the first pressure relief air passage 424 through a first switching valve 425, wherein the first switching valve 425 may be a solenoid valve, and a first speed regulating valve 426 is disposed in the first pressure relief air passage 424. It can be understood that, when the pressure in the first chamber 411 exceeds the preset range, the first switch valve 425 may be opened, so that the pressure in the first chamber 411 is discharged through the first pressure relief air passage 424, and the flow rate of the first pressure relief air passage 424 is adjusted through the first speed regulating valve 426, so as to implement slow pressure relief in the first chamber 411, and ensure a dynamic constant pressure state in the first chamber 411.
In some embodiments, as shown in fig. 25, the air circuit system 42 further includes a second pressure relief air circuit 427, a second switch valve 428, and a second speed valve 429; the second chamber 412 is controlled to communicate with a second pressure relief air path 427 by a second switching valve 428, wherein the second switching valve 428 may be a solenoid valve, and a second speed regulating valve 429 is disposed in the second pressure relief air path 427. It can be understood that, when the pressure in the second chamber 412 exceeds the preset range, the second on-off valve 428 may be opened to discharge the pressure in the second chamber 412 through the second pressure relief air path 427, and the flow rate of the second pressure relief air path 427 is adjusted through the second speed regulating valve 429, so as to realize slow pressure relief in the second chamber 412, reduce the flow rate of the make-up air in the second chamber 412, and further ensure the pressure fluctuation in the first chamber 411; therefore, through the mutual cooperation of first speed control valve 426 and second speed control valve 429, can effectively guarantee the constant voltage stability in first chamber 411, effectively guarantee that can be in dynamic constant voltage state for a long time in first chamber 411.
In some embodiments, as shown in fig. 25, the air path system 42 further includes a third pressure relief air path 431 and a third on-off valve 432, and the third pressure relief air path 431 is controlled to communicate with the first cavity 411 through the third on-off valve 432; it can be understood that after the air supply device 4 finishes supplying air, the third on/off valve 432 can control the third pressure relief air path 431 to communicate with the first cavity 411, so as to achieve rapid pressure relief in the first cavity 411. And/or, the air path system 42 further includes a fourth pressure relief air path 433 and a fourth switch valve 434, and the fourth pressure relief air path 433 is controlled by the fourth switch valve 434 to be communicated with the second chamber 412; it can be understood that after the air supply device 4 completes supplying air, the fourth switch valve 434 can control the fourth pressure relief air path 433 to communicate with the second chamber 412, so as to achieve rapid pressure relief in the second chamber 412. The third switching valve 432 and the fourth switching valve 434 may be switches that can be automatically opened and closed, such as solenoid valves.
In some embodiments, as shown in fig. 25, the air path system 42 further includes a second pressure sensor 435 and a fifth switch valve 436, and the second pressure sensor 435 is controlled to communicate with the first chamber 411 through the fifth switch valve 436. It is understood that the second pressure sensor 435 can be enabled to achieve the air-to-air correction in the first chamber 411 by controlling the second pressure sensor 435 to communicate with the first chamber 411 through the fifth switch valve 436, and the fifth switch valve 436 is in a normally closed state. And/or, the air passage system 42 further comprises a third pressure sensor 437 and a sixth switching valve 438, wherein the third pressure sensor 437 is controlled to communicate with the second chamber 412 through the sixth switching valve 438; it will be appreciated that the third pressure sensor 437 is enabled to achieve empty calibration in the second chamber 412 by controlling the third pressure sensor 437 to communicate with the second chamber 412 via a sixth switching valve 438, the sixth switching valve 438 being normally closed, wherein the fifth switching valve 436 and the sixth switching valve 438 may each be solenoid valves. Therefore, the second pressure sensor 435 and the third pressure sensor 437 are matched with each other, so that the first chamber 411 and the second chamber 412 can be corrected to be empty, and the consistency of the initial states of the first chamber 411 and the second chamber 412 is ensured. In addition, the air source device 4 further includes a circuit board disposed on the tank 41, and the circuit board is used for controlling the operation of the air path system 42, so as to maintain the pressure state in the first chamber 411 and the second chamber 412 within a preset range. In addition, this air supply unit 4 still includes the absolute pressure sensor that sets up on the circuit board, and this absolute pressure sensor is used for sensing the altitude and the ambient temperature that this air supply unit 4 is located, can make this air supply unit 4 carry out the air correction to first chamber 411 and second chamber 412 automatically according to the position that self is located, further guarantees the uniformity of first chamber 411 and the initial condition of second chamber 412.
In some embodiments, as shown in fig. 2 and 26, the in-vitro diagnostic apparatus 100 includes at least two detection mechanisms 10 independently disposed, each detection mechanism 10 being disposed side by side; each detection mechanism 10 comprises the pressure valve device 1, the card-inserting device 2, the stirring device 3 and the air source device 4. It can be understood that, the card inserting device 2 of each detecting mechanism 10 can be inserted with one reagent card 200, and is matched with the plurality of flow channels 220 of the reagent card 200, so that a plurality of detecting items can be integrated in one in vitro diagnostic apparatus 100, and each flow channel 220 of one reagent card 200 can be independently detected, so that a plurality of samples can be independently and simultaneously detected in one in vitro diagnostic apparatus 100, the operation is simple, the detecting efficiency can be effectively improved, and high-throughput detection can be realized.
In some embodiments, as shown in fig. 2, two detection mechanisms 10 are provided, two detection mechanisms 10 are arranged side by side in a first direction, and the pressure valve device 1 and the air source part are respectively provided on opposite sides of the card insertion device 2 in a second direction. Specifically, in this embodiment, two detection mechanisms 10 are all disposed on the mounting bracket 5, wherein the two detection mechanisms 10 are arranged on the mounting bracket 5 along the X-axis direction, the X-axis direction is the first direction, the pressure valve device 1, the card insertion device 2, and the air source device 4 are disposed on the mounting bracket 5 along the Y-axis direction of the mounting bracket 5, the Y-axis direction is the second direction, so as to integrate the two detection mechanisms 10 on one mounting bracket 5, thereby improving the compactness of the overall structure, effectively avoiding the mutual interference between each component between the detection mechanisms 10, and being matched with the four flow channels 220 of the reagent card 200, therefore, the in-vitro diagnostic apparatus 100 can simultaneously and independently realize the detection operation of eight samples, and further improving the detection efficiency.
In some embodiments, as shown in fig. 2, the mounting frame 5 includes a frame 53, and a first layer 54 and a second layer 55 disposed on the frame 53, the first layer 54 is disposed above the second layer 55, the detecting mechanism 10 is disposed on the first layer 54, and the plunger pump 6 is disposed on the second layer 55. It can be understood that the frame body 53 forms a layered structure, so that the detection mechanism 10 and the plunger pump 6 can be arranged correspondingly, the air suction operation of the plunger pump 6 to the reagent card 200 is facilitated, and the structural compactness is further improved.
The present embodiment further provides a control method of the in-vitro diagnostic apparatus 100, the control method is based on the in-vitro diagnostic apparatus 100, and includes the following steps:
inserting a reagent card 200 into a docking bay 211 of said card insertion device 2, the reagent card 200 having at least one flow channel 220 covered by a cover film 240;
at least one pressure valve member 12 of the pressure control valve device 1 moves relative to the card insertion device 2 to extend into the insertion groove 211 or extend out of the insertion groove 211; the pressure valve 12 extends into the insertion groove 211 and abuts against the reagent card 200, and presses the covering film 240 of the reagent card 200 to close the flow channel 220; the valve member 12 is separated from the reagent card 200 after extending out of the insertion groove 211, and the flow path 220 is in a communication state. It can be understood that, this external diagnostic apparatus 100 wears to locate card device 2 through the activity of pressure valve member 12, and pressure valve member 12 can stretch into the inserting groove 211 of card device 2 in order to offset with reagent card 200, so that when pressure valve member 12 moves to stretching into this inserting groove 211 relatively to card device 2, pressure valve member 12 can extrude the covering rete 240 on the reagent card 200 this moment, covering rete 240 can laminate the runner hole 230 of reagent card 200 after extrusion deformation, can be with the runner 220 shutoff of this reagent card 200 with the disconnection intercommunication, so, can realize independently opening or the disconnection of each runner 220 of accurate control through each pressure valve member 12, thereby realize the opening or the disconnection of each runner 220 of accurate control.
The in-vitro diagnostic apparatus 100 of one embodiment is briefly described below for the detection of thrombus elasticity patterns:
for easy understanding, when the in-vitro diagnostic apparatus 100 is used for detecting a thrombus elasticity pattern, the in-vitro diagnostic apparatus 100 is a thrombus elastogram detection device, and the detection principle of the thrombus elastogram detection device is as follows: by applying constant pressure to the blood sample, for example, applying constant pressure once every certain period of time, as the blood sample is gradually coagulated from a liquid state to a solid state in the sample placement area, the pressure applied during the phase transition of the blood sample is gradually reduced, so that a detection curve can be obtained by converting the change trend of the pressure in the sample placement area along with time according to the change condition of an output pressure signal, and the detection curve can represent the phase transition process of the blood sample. Specifically, when the in vitro diagnostic apparatus 100 is a thromboelastogram detection device, the thromboelastogram detection device includes a card insertion device 2, a pressure valve device 1, a stirring device 3, an air source device 4, and a valve island device. The card inserting device 2 is used for inserting a reagent card 200 to be detected, the pressure valve device 1 is used for controlling the opening or the disconnection of a flow channel 220 of the reagent card 200, the stirring device 3 is used for fully stirring a sample to be detected and a reagent which are introduced into the reagent card 200, the air source device 4 is used for applying constant pressure to the sample to be detected, the valve island device is used for controlling the air suction or pressurization operation of the reagent card 200, and the steps can be automatically controlled through the control system to form automatic detection.
The in vitro diagnostic apparatus 100 is a thrombelastogram detection device, and the detection process when used for detecting the thrombelastogram is as follows:
after the reagent card 200 is connected with the blood vessel rack 310, at this time, each flow channel 220 of the reagent card 200 is communicated with each plugging pipeline 320 of the blood vessel rack 310; the reagent card 200 is placed downwards above the insertion groove 211, the direction of the reagent card 200 is adjusted, the reagent card 200 is pressed downwards, the reagent card 200 and the blood vessel rack 310 push the rotating plate 241 to be opened and inserted into the insertion groove 211, at the moment, the reagent card 200 enters the second insertion groove 2112, the blood vessel rack 310 enters the first insertion groove 2111, the first positioning piece 221 elastically extends into the second insertion groove 2112 along the front face of the reagent card 200, the third positioning piece 222 elastically extends into the second insertion groove 2112 along the side face of the reagent card 200, and the reagent card 200 is initially positioned in the Y-axis direction and the X-axis direction.
The reagent card 200 is inserted into the bottom of the second slot 2112 and compresses the elastic mounting member 223, the external force is removed, the elastic mounting member 223 resets to drive the reagent card 200 to move upward until the locking hole of the reagent card 200 is opposite to the elastic self-locking rod, the elastic self-locking rod extends out and is inserted into the locking hole of the reagent card 200, the initial positioning of the reagent card 200 in the Z-axis direction is completed, and at this time, the in-place sensor can detect that the reagent card 200 is inserted.
The NFC reading module reads the NFC tag corresponding to the reagent card 200, obtains the type of the reagent card 200, and displays the type on the touch screen 51.
The second driving device 233 pushes the card pressing component 231 to move along the back of the reagent card 200 to extend into the second slot 2112, the second positioning component 232 on the card pressing component 231 is inserted into the corresponding card fixing hole on the back of the reagent card 200, and at this time, the second positioning component 232 performs secondary positioning on the reagent card 200, and cooperates with the first positioning component 221 to extend the reagent card 200 into the second slot 2112 in the front direction, so that the reagent card 200 can be positioned and locked in the front and back directions.
Inserting the blood collection tube 300 into the insertion tube 320 of the blood vessel holder 310, lighting the status indicator lamp 27 on the identification module 25, inserting the blood collection tube 300 into the corresponding insertion tube 320 to communicate with the flow channel 220 corresponding to the reagent card 200 according to the indication of the status indicator lamp 27, and determining whether the blood collection tube 300 is placed at the corresponding position according to whether the infrared ray emitted from the identification module 25 is blocked by the blood collection tube 300;
after the reagent card 200 is positioned, locked and identified, the second heating device of the card pressing assembly 231 and the first heating device 15 of the pressure valve device 1 heat the reagent card 200 together, the temperature in the second slot 2112 is rapidly increased to 37 +/-0.5 ℃ under the control of the first temperature sensing piece 2314, the temperature increase time is about 1min, and when the temperature reaches, the temperature is continuously controlled to 37 +/-0.2 ℃.
The air inlet channel 2315 of the pressure card plate 2311 extrudes the covering film layer 240 on the reagent card 200 to plug the corresponding air hole of the reagent card 200 to form a sealing state, the pressure valve device 1 plugs the flow passage hole 230 of the reagent card 200 through the pressure valve 12 to enable the flow passage 220 to form a plugging state, at the moment, air in the reagent card 200 is pumped through the plunger pump 6 to enable the reagent card 200 to form a negative pressure environment, and whether the gas leakage condition exists is sensed through a negative pressure detection element in the valve island device.
The blood sample in the blood collection tube 300 enters the flow channel 220 of the reagent card 200 and flows into the reagent chamber 210 in which the reagent is stored in advance to be mixed, and the stirring device 3 on the pressure valve body 11 stirs and mixes the blood sample and the reagent in the reagent card 200 according to the detection flow. After stirring for 1min, the pressure valve 12 controlling the detection area of the reagent card 200 is opened, and the blood sample enters the detection area from the reagent cavity 210, and the quantitative control of the blood sample is completed through the detection of the sensing element 14.
The air in the first cavity 411 of the tank 41 is controlled by the valve island device to enter the flow channel 220 of the reagent card 200, the air inlet-air outlet process is periodically repeated, the data at the end of the detection area of the reagent card 200 is recorded by the first pressure sensor 2316 on the pressing clamp plate 2311, the blood elasticity is changed along with the blood sample blood coagulation fibrinolysis, and the pressure value in the detection area is changed along with the change. The data collected by the pressure sensor is processed by hardware and software to generate a corresponding graph, and a corresponding thrombus elastogram graph of the detected blood sample is formed.
After the test is completed, a print function can be selected on the touch panel 51, and the test report of the blood sample to be tested is printed by the printer 52 to form a record of the completion.
When the drawing description is quoted, the new characteristics are explained; in order to avoid that repeated reference to the drawings results in an insufficiently concise description, the drawings are not referred to one by one in the case of clear description of the already described features.
The above embodiments are provided to illustrate, reproduce and deduce the technical solutions of the present invention, and to fully describe the technical solutions, the objects and the effects of the present invention, so as to make the public more thoroughly and comprehensively understand the disclosure of the present invention, and not to limit the protection scope of the present invention.
The above examples are not intended to be exhaustive of the invention and there may be many other embodiments not listed. Any alterations and modifications without departing from the spirit of the invention are within the scope of the invention.
Claims (25)
1. The in-vitro diagnostic instrument is characterized by comprising a card inserting device and a pressure valve device; the card inserting device is provided with an inserting groove for inserting a reagent card; the pressure valve device comprises at least one pressure valve, each pressure valve movably penetrates through the card inserting device, and the pressure valves can extend into the inserting grooves to abut against the reagent cards.
2. The in vitro diagnostic apparatus of claim 1, wherein the pressure valve means further comprises a pressure valve body and at least one first actuating means; press the valve body at least part to arrange in the inserting groove, press the valve body with press a swing joint, a drive arrangement with press a one-to-one setting, and each a drive arrangement can drive one press the valve relatively press the valve body to move to stretching into the inserting groove.
3. The in vitro diagnostic apparatus according to claim 2, wherein the output of the first actuating device is at least partially disposed opposite the valve pressing member, the output of the first actuating device being movable to press against the valve pressing member.
4. The in vitro diagnostic apparatus of claim 3, wherein the pressure valve means further comprises a first resilient member; the pressure valve part is provided with a blocking part, the first elastic part is arranged between the blocking part and the pressure valve body, and the acting force of the first elastic part on the pressure valve part is opposite to that of the first driving device.
5. The in vitro diagnostic apparatus according to claim 2, wherein the pressure valve body is provided with at least one through connection hole, and the connection holes are arranged in the pressure valve body in an array structure; the connecting hole with press the valve member one-to-one setting, just press the valve member activity to wear to locate in the connecting hole.
6. The in vitro diagnostic apparatus according to claim 2, wherein at least one sensing element for sensing the liquid flow is further disposed at an end of the pressure valve body adjacent to the insertion groove, and the sensing element is embedded in the pressure valve body.
7. The in vitro diagnostic apparatus of claim 2, wherein the pressure valve means further comprises first heating means; first heating device includes first heating film and first heat-conducting plate, first heat-conducting plate with press the valve body to be close to the one end of inserting groove is connected, first heating film set up in first heat-conducting plate is close to press one side of valve body.
8. The in vitro diagnostic apparatus according to claim 1, further comprising a stirring device connected to the pressure valve device;
the stirring device comprises a power assembly and an acting piece, the power assembly can drive the acting piece to move, a driving force for covering at least part of the region of the insertion groove can be formed when the acting piece moves, and the driving force is used for driving a driven piece located in the covered region to move.
9. The in vitro diagnostic apparatus of claim 8, wherein the motive assembly comprises a rotating device, a converting assembly, and a movable member;
the output end of the rotating device is connected with the conversion component, the moving part is connected with the conversion component, and the rotating device drives the moving part to reciprocate along the linear direction through the conversion component; the action piece is arranged on the moving piece.
10. The in vitro diagnostic apparatus of claim 9, wherein the translation assembly comprises a cam and guide assembly; the output end of the rotating device is connected with the cam, the moving part is meshed with the cam and movably arranged on the guide assembly, and the rotating device drives the cam to rotate and can drive the moving part to move linearly along the guide assembly.
11. The in-vitro diagnostic apparatus according to claim 10, wherein the conversion component further comprises a second elastic member, the movable member is connected with the guide component through the second elastic member, and the movable member is always in meshing transmission with the cam under the action of the second elastic member.
12. The in vitro diagnostic apparatus according to claim 8, wherein the acting member is a magnetic member capable of generating a magnetic attraction force or a magnetic repulsion force for attracting or repelling the driven member, and the magnetic attraction force or the magnetic repulsion force is the driving force.
13. The in vitro diagnostic apparatus of claim 1, wherein the card insertion device comprises a card insertion body and a first positioning assembly and a second positioning assembly movably connected to the card insertion body;
the card inserting main body is provided with the inserting groove; the first positioning assembly can at least partially extend into the insertion groove to perform primary positioning on the reagent card inserted into the insertion groove, and the second positioning assembly can at least partially extend into the insertion groove to perform secondary positioning on the reagent card inserted into the insertion groove.
14. The in vitro diagnostic apparatus of claim 13, wherein the first positioning element comprises a first positioning element disposed on the card body and elastically extending into the slot along a front surface of the card body; the second positioning assembly comprises a pressing and clamping assembly and a second positioning piece, the pressing and clamping assembly is movably arranged on the back face of the card inserting main body, and the second positioning piece is arranged on one side, close to the insertion groove, of the pressing and clamping assembly.
15. The in vitro diagnostic apparatus of claim 14, wherein the first positioning element further comprises a third positioning element disposed on the card body and elastically extending into the insertion slot along a side surface of the card body.
16. The in vitro diagnostic instrument of claim 14, wherein the second positioning assembly further comprises a second driving device, and the second driving device drives the pressing and clamping assembly to move back and forth in a direction approaching or separating from the insertion slot.
17. The in vitro diagnostic apparatus of claim 16, wherein the clamping assembly comprises a clamping plate and a second heating device; the output end of the second driving device is connected with the card pressing plate, and the second heating device is arranged on one side, facing the inserting groove, of the card pressing plate.
18. The in vitro diagnostic apparatus according to claim 17, wherein the second heating device comprises a second heating film and a second heat conducting plate, the second heat conducting plate is connected with the clamping plate, and the second heating film is disposed on one side of the second heat conducting plate close to the clamping plate.
19. The in vitro diagnostic apparatus of claim 17, further comprising a source of suction power; the pressure cardboard still has at least one inlet channel, inlet channel has the inlet end and gives vent to anger the end, the inlet end at least part stretches out the pressure cardboard and towards the inserting groove, just the inlet end stretches out the end that presses the cardboard is the loop configuration, the inlet end is used for sealing the intercommunication with the gas pocket of reagent card, give vent to anger the end with the power source intercommunication of bleeding.
20. The in vitro diagnostic apparatus according to claim 17, wherein the pressure plate is further provided with at least one pressure detection hole; the in-vitro diagnostic instrument further comprises a first pressure sensor and a sealing ring, and the first pressure sensor is arranged in the pressure detection hole in a sealing mode through the sealing ring.
21. The in vitro diagnostic apparatus of claim 1, wherein the insertion slot comprises a first slot and a second slot in communication with each other; the in-vitro diagnostic instrument further comprises an identification module and a reading module, wherein the identification module and the reading module are arranged on the card inserting device, the identification module is used for identifying the inserting state of the first slot, and the reading module is used for reading the information of the reagent card inserted into the second slot.
22. The in vitro diagnostic apparatus of claim 21, wherein the card insertion device comprises a card insertion body, a slot is further formed at a top end of the card insertion body, the card insertion body vertically forms the first slot and the second slot, the first slot and the second slot are sequentially communicated, the identification module is disposed at a position of the card insertion body corresponding to the first slot, and the reading module is disposed at a position of the card insertion body corresponding to the first slot or the second slot.
23. The in-vitro diagnostic apparatus according to claim 1, further comprising an air source device, wherein the air source device comprises a tank and an air path system, the tank has a first chamber and a second chamber, the second chamber is controlled by the air path system to communicate with the first chamber, the first chamber is used for communicating with the flow channel of the reagent card for air supply, and the volume of the first chamber is larger than that of the second chamber.
24. The in vitro diagnostic instrument of claim 23, wherein the air channel system comprises a main air channel, a branch air channel, and a one-way valve; the first cavity and the second cavity are respectively pressurized through the main gas circuit external gas generating device, the first cavity and the second cavity are communicated through the gas distributing circuit, and the one-way valve is arranged on the gas distributing circuit so that gas can enter the first cavity from the second cavity.
25. Method for controlling an in-vitro diagnostic apparatus, characterized in that it is based on an in-vitro diagnostic apparatus according to any one of claims 1 to 24, comprising the following steps:
inserting a reagent card into an insertion slot of the card insertion device, the reagent card having at least one flow channel covered by a cover film layer;
controlling at least one pressure valve part of the pressure valve device to move relative to the inserting and clamping device until the pressure valve part extends into the inserting and clamping groove or extends out of the inserting and clamping groove; the pressure valve piece extends into the insertion groove and abuts against the reagent card, and a covering film layer of the reagent card is extruded to seal the flow channel; the pressure valve piece extends out of the insertion groove and then is separated from the reagent card, and the flow channel is communicated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210135573.XA CN114487455A (en) | 2022-02-14 | 2022-02-14 | In-vitro diagnostic instrument and control method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210135573.XA CN114487455A (en) | 2022-02-14 | 2022-02-14 | In-vitro diagnostic instrument and control method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114487455A true CN114487455A (en) | 2022-05-13 |
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ID=81480717
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210135573.XA Pending CN114487455A (en) | 2022-02-14 | 2022-02-14 | In-vitro diagnostic instrument and control method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114487455A (en) |
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2022
- 2022-02-14 CN CN202210135573.XA patent/CN114487455A/en active Pending
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