CN114470820B - A nano-material drying system for preparation of PTX @ SN38-NMs - Google Patents
A nano-material drying system for preparation of PTX @ SN38-NMs Download PDFInfo
- Publication number
- CN114470820B CN114470820B CN202210217263.2A CN202210217263A CN114470820B CN 114470820 B CN114470820 B CN 114470820B CN 202210217263 A CN202210217263 A CN 202210217263A CN 114470820 B CN114470820 B CN 114470820B
- Authority
- CN
- China
- Prior art keywords
- filter membrane
- module
- field
- organic solvent
- capturing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Images
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/22—Evaporating by bringing a thin layer of the liquid into contact with a heated surface
- B01D1/24—Evaporating by bringing a thin layer of the liquid into contact with a heated surface to obtain dry solids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/16—Evaporating by spraying
- B01D1/18—Evaporating by spraying to obtain dry solids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/30—Accessories for evaporators ; Constructional details thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Drying Of Solid Materials (AREA)
Abstract
The invention discloses a nano material drying system for preparing PTX @ SN38-NMs, which comprises a machine body group, a warm air module, a filter membrane surface treatment module and a free particle capture module, wherein the warm air module is arranged at the central position in the machine body group, and acts on the non-interception surface of a filter membrane fixed on the upper end surface of the filter membrane by generating uniform circulating warm air, the filter membrane surface treatment module is a plurality of groups of atomizing nozzles distributed on the upper side of the interception surface of the filter membrane in a surrounding manner, and the free particle capture module is arranged right above the central position of the interception surface of the filter membrane. The invention is provided with the filter membrane surface treatment module, adopts a mode of spraying organic solvent to replace the traditional washing mode, can solve the problem of large organic solvent consumption of the traditional organic solvent washing method for drying the nano particles, and is provided with the free particle capture module, so that the nano particles in a free state in the drying process can be captured, the loss rate of the nano particles in the drying process is reduced, and the acquisition rate of the particles is improved.
Description
Technical Field
The invention relates to the field of nano material preparation, in particular to a nano material drying system for preparing PTX @ SN38-NMs.
Background
Glioma is one of the most lethal and common primary brain tumors, known to affect 0.02% of the population. Although glioblastoma is a rare tumor, its poor survival rate makes it an important health problem. Standard treatment for glioblastoma typically involves post-operative chemotherapy. However, these treatments are not considered effective in controlling the disease, resulting in survival times of less than 15 months. In addition, the resistance and toxic effects of chemotherapeutic drugs suggest that chemotherapy is insufficient to combat the disease. In addition, poor drug permeability due to physiological barriers such as the blood-brain barrier and the blood-brain tumor barrier is another important limitation in therapy. Therefore, it is highly desirable to find novel anticancer drugs with low toxicity and high efficacy for effectively treating glioblastoma.
PTX @ SN38-NMs is a novel anti-cancer drug proposed for glioma treatment, and relevant studies indicate that PTX @ SN38-NM is intravenously injected into xenografted LN229 cells. Compared with the free drug (PTX + SN 38), PTX @ SN38-NMs can significantly inhibit tumor development, prolong survival time and reduce side effects, indicating the chemotherapeutic efficiency of the drug delivery system. The particle size of PTX @ SN38-NMs is 27.97 +/-1.87 nm, and a filter is required to purify the nano material solution in the drug production process. And drying the filter paper of the filter in a hot air box to obtain PTX @ SN38-NMs, wherein the nano particles on the surface of the outer layer of the filter membrane are firstly dried along with the drying process, and the part of particles are easy to become free and float in the drying box, so that the drug loss is caused, and the yield is reduced. In addition, the preparation method of the PTX @ SN38-NMs nanoparticles is a liquid phase method, but the surface energy of the nanoparticles is very large due to quite small particle size and very large dispersity, so that the traditional drying method is very easy to cause the agglomeration phenomenon of the nanoparticles in the drying and dewatering steps in the preparation process of the liquid phase method. To this end, we propose a nanomaterial drying system for the preparation of ptx @ sn38-NMs.
Disclosure of Invention
The invention mainly aims to provide a nano material drying system for preparing PTX @ SN38-NMs, which can effectively solve the problems in the background technology.
In order to realize the purpose, the invention adopts the technical scheme that: the utility model provides a nano-material drying system for preparation of PTX @ SN38-NMs, includes organism group, warm braw module, filter membrane surface treatment module and free particle capture module, the warm braw module is installed in the central point department of organizing inside, acts on the non-surface of damming of the filter membrane of fixed up end through producing even circulation warm braw, filter membrane surface treatment module is for surrounding a plurality of groups atomizer that distribute in the surface upside that dams of filter membrane, pumps atomizer department with organic solvent pump through pump liquid equipment and infusion pipeline to evenly spray the surface that dams to the filter membrane in the drying process, free particle capture module is installed directly over the surface central point that dams of filter membrane and is put, and free particle capture module upper end is organized with the organism and is connected.
The free particle capturing module comprises a flow guiding field, an air nozzle, an angle regulator, a capturing field and a capturing plate and is used for capturing nano particles in a free state in the drying process, the flow guiding field and the capturing field are hollow cylindrical devices which are communicated with each other and are arranged in a crenellated mode, the air nozzle is uniformly distributed on the inner walls of the flow guiding field and the capturing field through the angle regulator, and the capturing plate is arranged at the connecting position of the central axis of the capturing field and a machine body group.
Further, the warm braw module includes hot plate, heat pipe, drainage cover, wind-equalizing net, workstation and mount for provide the required heat of nanometer particle stoving, the hot plate is installed in the inside lower terminal surface of organism group, heat pipe one end is connected with the hot plate, and the other end is equipped with the drainage cover, and the tip is connected with the workstation, wind-equalizing net is installed in the pipe wall department of heat pipe and workstation junction, the up end in the workstation is installed to the mount.
Furthermore, catch the board and set up for hollow inverted round platform form, and catch the board bottom surface down and be the magnetic sheet, go up the bottom surface and evenly be equipped with a plurality of hole of airing exhaust.
Further, the organic solvent is a dichloromethane solution.
Further, the operation flow of the drying system is as follows:
setting an initial drying temperature of a warm air module, conveying warm air to a workbench along a heat conduction pipe, uniformly acting on a non-interception surface of a filter membrane at a temperature lower than the boiling point of an organic solvent, pumping the organic solvent into an atomizing nozzle of a filter membrane surface treatment module through a liquid pumping device and a liquid conveying pipeline in an initial drying stage, and uniformly spraying the organic solvent onto a cut-off surface of the filter membrane in a drying process;
step two, measuring the water content of the filter membrane at intervals, and when the measured water content of the filter membrane is less than 10%, adjusting the operating temperature of the warm air module to ensure that the warm air module dries the filter membrane at a boiling point slightly lower than that of the organic solvent until the filter membrane is completely dried;
and step three, adjusting the air nozzle arranged on the inner wall of the diversion field through an angle adjuster to enable the air nozzle to perform air injection operation at a certain angle, so that stable spiral ascending air flow is formed in the diversion field, the nano particles in a free state in the diversion field are guided to the capture field, adjusting the air nozzle arranged on the inner wall of the diversion field through the angle adjuster to enable the air nozzle to perform air injection operation along the tangential direction of the inner wall of the capture field, stable annular air flow is formed in the capture field, and the nano particles in the annular air flow are adsorbed through a magnetic plate at the lower end of the capture plate.
Compared with the prior art, the invention has the following beneficial effects:
(1) The hot air module is used for providing heat required by drying the nano particles, the heating plate generates heat, the heat is conducted to the workbench through the heat conduction pipe, when hot air is transmitted to the air equalizing net, uniform and slow hot air flow is formed to act on the non-throttling surface of the filter membrane, meanwhile, a drainage cover is arranged at the joint of the heat conduction pipe and the workbench, when the temperature of the workbench rises, after the hot air is gathered, partial air flow is discharged from the drainage cover, stable hot air flow is formed, the stability of the temperature in the drying process is kept, the phenomenon that the temperature difference between the upper end surface and the lower end surface of the filter membrane is too large due to overhigh temperature is prevented, and the drying effect is improved;
(2) The filter membrane surface treatment module is arranged, the traditional washing mode is replaced by the organic solvent spraying mode, the organic solvent can be connected with the nano particles on the surface intercepted by the filter membrane in an atomizing mode, the using amount of the organic solvent can be reduced, the problem of high organic solvent consumption in the drying process of the nano particles by the traditional organic solvent washing method is solved, and meanwhile, the parameters such as the atomizing degree, the spraying amount, the spraying time period and the like of the organic solvent can be accurately controlled, so that the organic solvent is fully contacted with the nano particles, and the agglomeration phenomenon of the nano particles in the drying process is reduced;
(3) Set up free particle and catch the module, adjust the air nozzle of installing in the induced flow field inner wall through the angle regulator, make the air nozzle carry out jet-propelled operation with certain angle, thereby form stable heliciform updraft in induced flow field, and be the nano particles drainage of free state to the catch field in with induced flow field, and form stable annular air current in the catch field, the magnetic sheet through catch plate lower extreme adsorbs the nano particles in with annular air current, can catch the nano particles that are free state, reduce the loss rate of drying in-process nano particles, improve the acquisition rate of particle.
Drawings
FIG. 1 is a schematic view of the overall structure of the drying system of the present invention;
FIG. 2 is an exploded view of the heater module of the present invention;
FIG. 3 is a schematic view of the distribution structure of the air nozzles in the flow guiding field according to the present invention;
FIG. 4 is a schematic view of the distribution structure of the air nozzles in the capture field according to the present invention;
FIG. 5 is a schematic view of the structure of the capture plate of the present invention.
In the figure: 1. a body group; 2. a warm air module; 21. heating the plate; 22. a heat conducting pipe; 23. a drainage cover; 24. a wind equalizing net; 25. a work table; 26. a fixed mount; 3. a filter membrane surface treatment module; 4. a free particle capture module; 41. a flow guiding field; 42. an air nozzle; 43. an angle adjuster; 44. a field of capture; 45. a capture plate.
Detailed Description
The present invention will be further described with reference to the following detailed description, wherein the drawings are for illustrative purposes only and are not intended to be limiting, and certain features of the drawings are omitted, enlarged or reduced in size, and are not intended to represent the actual product size.
Example 1
As shown in the figures 1-2, the nano material drying system for preparing PTX @ SN38-NMs comprises a machine body group 1, a warm air module 2, a filter membrane surface treatment module 3 and a free particle capturing module 4, wherein the warm air module 2 is installed at the central position inside the machine body group 1, the non-interception surface of a filter membrane fixed on the upper end surface of the filter membrane is acted by generating uniform circulating warm air, the filter membrane surface treatment module 3 is a plurality of groups of atomizing nozzles distributed on the upper side of the interception surface of the filter membrane in a surrounding mode, an organic solvent is pumped into the atomizing nozzles through a liquid pumping device and a liquid conveying pipeline and is uniformly sprayed to the interception surface of the filter membrane in the drying process, the free particle capturing module 4 is installed right above the central position of the interception surface of the filter membrane, and the upper end of the free particle capturing module 4 is connected with the machine body group 1.
The free particle capturing module 4 comprises a flow guiding field 41, an air nozzle 42, an angle regulator 43, a capturing field 44 and a capturing plate 45, and is used for capturing nano particles in a free state in the drying process, the flow guiding field 41 and the capturing field 44 are hollow cylindrical devices which are communicated with each other and are provided with crenellations, the air nozzle 42 is uniformly distributed on the inner walls of the flow guiding field 41 and the capturing field 45 through the angle regulator 43, and the capturing plate 45 is arranged at the joint of the central axis of the capturing field 44 and the machine body group 1.
The warm air module 2 comprises a heating plate 21, a heat pipe 22, a flow guide cover 23, an air equalizing net 24, a workbench 25 and a fixing frame 26, and is used for providing heat required by drying nano particles, the heating plate 21 is installed on the lower end face of the inside of the machine body group 1, one end of the heat pipe 22 is connected with the heating plate 21, the other end of the heat pipe is provided with the flow guide cover 23, the end part of the heat pipe is connected with the workbench 25, the air equalizing net 24 is installed on the pipe wall of the joint of the heat pipe 22 and the workbench 25, and the fixing frame 26 is installed on the upper end face of the workbench 25.
By adopting the technical scheme: the warm air module that sets up is used for providing the required heat of nanometer particle stoving, produce the heat by hot plate 21, and conduct the heat to workstation 25 department through heat pipe 22, when hot-air transfer to the net 24 department of samming, form even slow hot gas flow and act on the non-throttling surface of filter membrane, thereby can carry out slow stoving with the filter membrane, be provided with flow guide cover 23 in the junction of heat pipe 22 and workstation 25 simultaneously, temperature when workstation 25 department rises, after the hot-air gathering, some air flow is discharged by flow guide cover 23, be favorable to forming stable hot gas flow, keep the stability of stoving in-process temperature, prevent that the high temperature from leading to the filter membrane about the terminal surface difference in temperature too big, improve the stoving effect.
Example 2
As shown in the figures 1-2, the nano material drying system for preparing PTX @ SN38-NMs comprises a machine body group 1, a warm air module 2, a filter membrane surface treatment module 3 and a free particle capturing module 4, wherein the warm air module 2 is installed at the central position inside the machine body group 1, the non-interception surface of a filter membrane fixed on the upper end surface of the filter membrane is acted by generating uniform circulating warm air, the filter membrane surface treatment module 3 is a plurality of groups of atomizing nozzles distributed on the upper side of the interception surface of the filter membrane in a surrounding mode, an organic solvent is pumped into the atomizing nozzles through a liquid pumping device and a liquid conveying pipeline and is uniformly sprayed to the interception surface of the filter membrane in the drying process, the free particle capturing module 4 is installed right above the central position of the interception surface of the filter membrane, and the upper end of the free particle capturing module 4 is connected with the machine body group 1.
The free particle capturing module 4 comprises a flow guiding field 41, an air nozzle 42, an angle regulator 43, a capturing field 44 and a capturing plate 45, and is used for capturing nano particles in a free state in the drying process, the flow guiding field 41 and the capturing field 44 are hollow cylindrical devices which are communicated with each other and are provided with crenellations, the air nozzle 42 is uniformly distributed on the inner walls of the flow guiding field 41 and the capturing field 45 through the angle regulator 43, and the capturing plate 45 is arranged at the joint of the central axis of the capturing field 44 and the machine body group 1. The organic solvent is a dichloromethane solution.
By adopting the technical scheme: in the process of drying the nano particles, three acting forces of nano particle surface energy, liquid tension and nano particle and liquid interface tension exist, the nano particle system forms a stable state, along with continuous volatilization of liquid in the nano particle system, under the combined action of the three acting forces, adjacent nano particle systems start to gradually shrink, after the liquid volatilizes to a certain degree, the nano particles are not filled with the liquid, the balance among the stable systems formed by the three acting forces is broken, a large number of bent liquid surfaces are formed among the particles, additional pressure generated by the bent liquid surfaces causes the shrinkage effect to generate, the adjacent particles are continuously close to each other, the initial interaction bonds among a certain number of nano particles are broken to form new bonds, the particles are aggregated into secondary particles, the surface energy of the particles is reduced, the stable state is formed again, namely the particle aggregation phenomenon, by spraying the organic solvent to the particles in the drying process, in the process of washing the particles, the organic solvent takes away part of water and replaces the water to exist among the particles, so that part of non-bridging hydroxyl groups are replaced by organic functional groups, the formation of the hydroxyl groups is avoided, on the other hand, a certain steric hindrance effect is also achieved, the distance among the particles is increased, and the agglomeration phenomenon of the particles is reduced, the arranged filter membrane surface treatment module 3 is adopted, the organic solvent is pumped into an atomizing nozzle of the filter membrane surface treatment module 3 through a liquid pumping device and a liquid conveying pipeline and is uniformly sprayed to the interception surface of the filter membrane in the drying process, so that the organic solvent can be connected with the nano particles on the interception surface of the filter membrane in an atomizing mode, the use amount of the organic solvent can be reduced, and the problem of large organic solvent consumption in the drying of the nano particles by the traditional organic solvent washing method is solved, meanwhile, parameters such as the atomization degree, the spraying amount and the spraying time period of the organic solvent can be accurately controlled, the organic solvent is in full contact with the nanoparticles, the agglomeration phenomenon of the nanoparticles in the drying process is reduced, dichloromethane is adopted as a flushing solvent, and is favorable for occupying gaps of the nanoparticles after water evaporation, so that a new stable system is formed, and the dichloromethane is an organic compound, the boiling point of the dichloromethane is 39.8 ℃, so that the drying temperature of the system can be controlled at a lower level, and the energy is saved.
Example 3
As shown in fig. 1-4, a nanomaterial drying system for ptx @ sn38-NMs preparation, comprises a machine body group 1, a warm air module 2, a filter membrane surface treatment module 3 and a free particle capture module 4, wherein the warm air module 2 is installed at the central position inside the machine body group 1, acts on the non-interception surface of the filter membrane fixed on the upper end surface thereof by generating uniform circulating warm air, the filter membrane surface treatment module 3 is a plurality of groups of atomizer nozzles distributed around the interception surface upper side of the filter membrane, an organic solvent is pumped into the atomizer nozzles through a liquid pumping device and a liquid conveying pipeline and is uniformly sprayed to the interception surface of the filter membrane in the drying process, the free particle capture module 4 is installed right above the interception surface central position of the filter membrane, and the upper end of the free particle capture module 4 is connected with the machine body group 1.
The free particle capturing module 4 comprises a flow guiding field 41, an air nozzle 42, an angle regulator 43, a capturing field 44 and a capturing plate 45 and is used for capturing nano particles in a free state in the drying process, the flow guiding field 41 and the capturing field 44 are arranged in a hollow cylindrical shape which is communicated with each other and is provided with crenellations, the air nozzle 42 is uniformly distributed on the inner walls of the flow guiding field 41 and the capturing field 45 through the angle regulator 43, and the capturing plate 45 is arranged at the joint of the central axis of the capturing field 44 and the machine body group 1.
The warm air module 2 comprises a heating plate 21, a heat conducting pipe 22, a flow guide cover 23, an air equalizing net 24, a workbench 25 and a fixing frame 26 and is used for providing heat required by drying nano particles, the heating plate 21 is installed on the inner lower end face of the machine body group 1, one end of the heat conducting pipe 22 is connected with the heating plate 21, the other end of the heat conducting pipe is provided with the flow guide cover 23, the end part of the heat conducting pipe is connected with the workbench 25, the air equalizing net 24 is installed on the pipe wall of the joint of the heat conducting pipe 22 and the workbench 25, and the fixing frame 26 is installed on the upper end face of the workbench 25. The organic solvent is a dichloromethane solution.
By adopting the technical scheme: at the earlier stage of drying operation, the filter membrane water content is higher, the evaporation of water is quicker, the agglomeration phenomenon among the particles is aggravated, the amount of the sprayed organic solvent is increased in a proper amount, the organic solvent with enough amount is filled among the particles, the occurrence of the agglomeration phenomenon is slowed down, the water content of the filter membrane is measured at intervals, the spraying amount of the organic solvent of the filter membrane surface treatment module 3 is adjusted in real time, when the water content of the measured filter membrane is less than 10%, the water content among the particles is at a lower level at the moment, the spraying amount of the organic solvent with large amount is smaller for preventing the agglomeration phenomenon among the particles, the spraying amount of the organic solvent is reduced by fixing, the running temperature of the warm air module 2 is adjusted at the same time, the filter membrane is dried by the boiling point slightly lower than the organic solvent by the warm air module 2, at the moment, the moisture among the particles is continuously evaporated, the organic solvent is also evaporated at the temperature lower than the boiling point, the boiling phenomenon can not be continuously generated, the stable new bond formed by the nano particles is prevented from being broken under the unstable state, and the physical stability among the nano particles can be favorably kept.
Example 4
As shown in fig. 1-5, a nanomaterial drying system for ptx @ sn38-NMs preparation, comprises a machine body group 1, a warm air module 2, a filter membrane surface treatment module 3 and a free particle capture module 4, wherein the warm air module 2 is installed at the central position inside the machine body group 1, acts on the non-interception surface of the filter membrane fixed on the upper end surface thereof by generating uniform circulating warm air, the filter membrane surface treatment module 3 is a plurality of groups of atomizer nozzles distributed around the interception surface upper side of the filter membrane, an organic solvent is pumped into the atomizer nozzles through a liquid pumping device and a liquid conveying pipeline and is uniformly sprayed to the interception surface of the filter membrane in the drying process, the free particle capture module 4 is installed right above the interception surface central position of the filter membrane, and the upper end of the free particle capture module 4 is connected with the machine body group 1.
The free particle capturing module 4 comprises a flow guiding field 41, an air nozzle 42, an angle regulator 43, a capturing field 44 and a capturing plate 45 and is used for capturing nano particles in a free state in the drying process, the flow guiding field 41 and the capturing field 44 are arranged in a hollow cylindrical shape which is communicated with each other and is provided with crenellations, the air nozzle 42 is uniformly distributed on the inner walls of the flow guiding field 41 and the capturing field 45 through the angle regulator 43, and the capturing plate 45 is arranged at the joint of the central axis of the capturing field 44 and the machine body group 1.
The warm air module 2 comprises a heating plate 21, a heat pipe 22, a flow guide cover 23, an air equalizing net 24, a workbench 25 and a fixing frame 26, and is used for providing heat required by drying nano particles, the heating plate 21 is installed on the lower end face of the inside of the machine body group 1, one end of the heat pipe 22 is connected with the heating plate 21, the other end of the heat pipe is provided with the flow guide cover 23, the end part of the heat pipe is connected with the workbench 25, the air equalizing net 24 is installed on the pipe wall of the joint of the heat pipe 22 and the workbench 25, and the fixing frame 26 is installed on the upper end face of the workbench 25.
By adopting the technical scheme: at the later stage of the drying operation, as the water content of the filter membrane is gradually reduced, the water content of the nanoparticles is also gradually reduced, the nanoparticle layer on the upper layer is firstly dried, in the process of forming new bonds among the nanoparticles, because a new particle system is not stable yet, and the surface energy of the particles is increased under the environment of hot air flow, part of the particles are separated from the original system and are suspended and dried in a free state, at the moment, the air nozzle 42 arranged on the inner wall of the flow guiding field 41 is adjusted through the angle adjuster 43, so that the air nozzle 42 performs air injection operation at a certain angle, a stable spiral ascending air flow is formed in the flow guiding field 41, the nanoparticles in a free state in the flow guiding field 41 are guided into the capture field 44, the air nozzle 42 arranged on the inner wall of the flow guiding field 41 is adjusted through the angle adjuster 43, the air nozzle 42 performs air injection operation along the tangential direction of the inner wall of the capture field 44, a stable annular air flow (the dotted arrow in the figure is an air flow direction), the nanoparticles in the magnetic plate-shaped air flow at the lower end of the capture plate 45 are adsorbed, the hot air flow, so that the nanoparticles flow flows out of the holes, the exhaust holes on the capture field 44, the exhaust holes, the nanoparticles are reduced, and the nanoparticles in the drying process of the nanoparticles, and the nanoparticles are obtained nanoparticles, and the nanoparticles in the free state, and the nanoparticles are reduced in the drying process of the nanoparticles.
It should be noted that, in the present invention, when the nano material drying system for ptx @ sn38-NMs preparation is used, an initial drying temperature of the warm air module 2 is set, so that the warm air is conveyed to the workbench 25 along the heat conduction pipe 22 and uniformly acts on the non-interception surface of the filter membrane at a temperature lower than the boiling point of the organic solvent, in an initial drying stage, the organic solvent is pumped into the atomizing nozzle of the filter membrane surface treatment module 3 through a liquid pumping device and a liquid conveying pipe and is uniformly sprayed to the interception surface of the filter membrane in the drying process, the water content of the filter membrane is measured at intervals, when the measured water content of the filter membrane is less than 10%, the operating temperature of the warm air module 2 is adjusted, so that the warm air module 2 dries the filter membrane to be completely dried at a temperature slightly lower than the boiling point of the organic solvent, the air nozzle 42 mounted on the inner wall of the guiding field 41 is adjusted by the angle adjuster 43, the air nozzle 42 is operated at a certain angle, so that a stable spiral rising air flow is formed in the guiding field 41, the nano particles in the guiding field 41 are captured by the air nozzle 43, and the air nozzle is mounted on the inner wall of the guiding field 44, and nano particles are captured by the magnetic field, and the air nozzle 44, and the nano particles are captured by the jet nozzle 44, and the jet nozzle is captured by the jet nozzle 44, and the jet nozzle 44, so that the magnetic particle capturing operation is stably captured in the magnetic field.
The foregoing shows and describes the general principles and broad features of the present invention and advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.
Claims (5)
1. A nano-material drying system for preparing PTX @ SN38-NMs comprises a machine body group (1), a warm air module (2), a filter membrane surface treatment module (3) and a free particle capture module (4), and is characterized in that: the warm air module (2) is arranged at the center position inside the machine body group (1), and acts on the non-interception surface of the filter membrane fixed on the upper end surface of the filter membrane by generating uniform circulating warm air, the filter membrane surface treatment module (3) is a plurality of groups of atomizing nozzles distributed on the upper side of the interception surface of the filter membrane in a surrounding manner, an organic solvent is pumped into the atomizing nozzles by pump liquid equipment and a liquid conveying pipeline and is uniformly sprayed to the interception surface of the filter membrane in the drying process, the free particle capture module (4) is arranged right above the center position of the interception surface of the filter membrane, and the upper end of the free particle capture module (4) is connected with the machine body group (1);
the free particle capturing module (4) comprises a flow guiding field (41), an air nozzle (42), an angle regulator (43), a capturing field (44) and a capturing plate (45) and is used for capturing nano particles in a free state in a drying process, the flow guiding field (41) and the capturing field (44) are arranged in a hollow cylindrical shape which is communicated with each other and is used for carrying out crenellation installation, the air nozzle (42) is uniformly distributed on the inner walls of the flow guiding field (41) and the capturing field (44) through the angle regulator (43), and the capturing plate (45) is arranged at the joint of the central axis of the capturing field (44) and the machine body group (1).
2. A nanomaterial drying system for PTX @ SN38-NMs preparation according to claim 1, characterized in that: warm braw module (2) are including hot plate (21), heat pipe (22), drainage cover (23), wind-equalizing net (24), workstation (25) and mount (26) for provide the required heat of nanometer particle stoving, terminal surface under the inside of organism group (1) is installed in hot plate (21), heat pipe (22) one end is connected with hot plate (21), and the other end is equipped with drainage cover (23), and the tip is connected with workstation (25), wind-equalizing net (24) are installed in the pipe wall department of heat pipe (22) and workstation (25) junction, mount (26) are installed in the up end of workstation (25).
3. A nano-material drying system for PTX @ SN38-NMs preparation according to claim 1, characterized in that: catch board (45) and set up for hollow inverted round platform form, and catch board (45) lower bottom surface and be the magnetic sheet, go up the bottom surface and evenly be equipped with a plurality of hole of airing exhaust.
4. A nanomaterial drying system for PTX @ SN38-NMs preparation according to claim 1, characterized in that: the organic solvent is dichloromethane solution.
5. A nanomaterial drying system for the preparation of PTX @ SN38-NMs according to any one of claims 1 to 4, characterized in that: the operation flow of the drying system is as follows:
setting an initial drying temperature of the warm air module (2), conveying warm air to a workbench (25) along a heat conduction pipe (22), uniformly acting on a non-interception surface of a filter membrane at a temperature lower than the boiling point of an organic solvent, pumping the organic solvent into an atomizing nozzle of the filter membrane surface treatment module (3) through liquid pumping equipment and a liquid conveying pipeline in an initial drying stage, and uniformly spraying the organic solvent onto an interception surface of the filter membrane in a drying process;
step two, measuring the water content of the filter membrane at intervals, and when the measured water content of the filter membrane is less than 10%, adjusting the operating temperature of the warm air module (2) to ensure that the warm air module (2) dries the filter membrane at a boiling point slightly lower than that of the organic solvent until the filter membrane is completely dried;
adjusting the air nozzle (42) arranged on the inner wall of the flow guiding field (41) through an angle adjuster (43), enabling the air nozzle (42) to perform air injection operation at a certain angle, so that stable spiral ascending air flow is formed in the flow guiding field (41), guiding the nanoparticles in the flow guiding field (41) in a free state to the capture field (44), adjusting the air nozzle (42) arranged on the inner wall of the flow guiding field (41) through the angle adjuster (43), enabling the air nozzle (42) to perform air injection operation along the tangential direction of the inner wall of the capture field (44), forming stable annular air flow in the capture field (44), and adsorbing the nanoparticles in the annular air flow through a magnetic plate at the lower end of the capture plate (45).
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210217263.2A CN114470820B (en) | 2022-03-07 | 2022-03-07 | A nano-material drying system for preparation of PTX @ SN38-NMs |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210217263.2A CN114470820B (en) | 2022-03-07 | 2022-03-07 | A nano-material drying system for preparation of PTX @ SN38-NMs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114470820A CN114470820A (en) | 2022-05-13 |
| CN114470820B true CN114470820B (en) | 2023-04-07 |
Family
ID=81485528
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210217263.2A Active CN114470820B (en) | 2022-03-07 | 2022-03-07 | A nano-material drying system for preparation of PTX @ SN38-NMs |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114470820B (en) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001334132A (en) * | 2000-05-30 | 2001-12-04 | Sumitomo Chem Co Ltd | Method and device for spray-drying |
| CN105324330A (en) * | 2013-06-19 | 2016-02-10 | 潘可士玛股份公司 | Elemental selenium nanoparticles and production method |
| CN106687110A (en) * | 2014-07-03 | 2017-05-17 | 石药集团中奇制药技术（石家庄）有限公司 | Purified therapeutic nanoparticles and preparation methods thereof |
| CN113860352A (en) * | 2021-09-25 | 2021-12-31 | 河北工程大学 | Preparation method of nano copper oxide-graphite phase carbon nitride composite material and drying device for preparation |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20160271513A1 (en) * | 2013-10-29 | 2016-09-22 | President And Fellows Of Harvard College | Drying techniques for microfluidic and other systems |
-
2022
- 2022-03-07 CN CN202210217263.2A patent/CN114470820B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001334132A (en) * | 2000-05-30 | 2001-12-04 | Sumitomo Chem Co Ltd | Method and device for spray-drying |
| CN105324330A (en) * | 2013-06-19 | 2016-02-10 | 潘可士玛股份公司 | Elemental selenium nanoparticles and production method |
| CN106687110A (en) * | 2014-07-03 | 2017-05-17 | 石药集团中奇制药技术（石家庄）有限公司 | Purified therapeutic nanoparticles and preparation methods thereof |
| CN113860352A (en) * | 2021-09-25 | 2021-12-31 | 河北工程大学 | Preparation method of nano copper oxide-graphite phase carbon nitride composite material and drying device for preparation |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114470820A (en) | 2022-05-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| WO2022218067A1 (en) | Atomizing core material, atomizing core and preparation method therefor, and electronic atomizing apparatus | |
| CN208136501U (en) | A kind of modified textile humidifier | |
| CN114470820B (en) | A nano-material drying system for preparation of PTX @ SN38-NMs | |
| CN111974012A (en) | Experimental spray dryer for environmental protection chemical production | |
| CN110791884B (en) | Device and method for preparing photo-thermal water evaporation nanofiber composite membrane | |
| CN109939455A (en) | A kind of spray drying evaporating column spiral case matching air box | |
| CN105621509B (en) | The humidification of fluidized bed enhanced water evaporation removes wet type water purification installation | |
| CN207221361U (en) | A kind of medicine extracts processing unit (plant) | |
| CN207338531U (en) | A kind of lead-acid battery curing room | |
| CN209801928U (en) | Water atomization metal powder water bath drying system | |
| CN211885420U (en) | Powder spray drying tower | |
| CN208269611U (en) | A kind of energy-saving monkshood drying unit of formula in batches | |
| CN212016756U (en) | A concentrated drying device for tea-oil camellia saponin | |
| CN208990265U (en) | A kind of spray-drying installation | |
| CN208104756U (en) | A kind of textile humidifier | |
| CN207786535U (en) | A kind of fluidized bed coating process units | |
| CN208893650U (en) | A kind of Chinese medicinal material extract spray-drying installation | |
| CN203710811U (en) | Pure dry mist filter | |
| CN206875650U (en) | Liquid gasification equipment | |
| CN209685354U (en) | High saline sewage evaporative crystallization processing unit | |
| CN208011756U (en) | A kind of low boiling oil spray nozzle | |
| CN205161702U (en) | Heat accumulating type steam generator | |
| CN202232661U (en) | Spraying machine capable of changing diameter of fog drips | |
| CN108355897B (en) | Enhanced diffusion type photocatalyst atomizer | |
| CN207451662U (en) | High concentration ammonium hydroxide stripping processing unit |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |