CN114470820A

CN114470820A - Nanomaterial drying system for PTX @ SN38-NMs preparation

Info

Publication number: CN114470820A
Application number: CN202210217263.2A
Authority: CN
Inventors: 王晓英; 万学锋; 刘夏桐
Original assignee: Zhumadian Central Hospital
Current assignee: Zhumadian Central Hospital
Priority date: 2022-03-07
Filing date: 2022-03-07
Publication date: 2022-05-13
Anticipated expiration: 2042-03-07
Also published as: CN114470820B

Abstract

The invention discloses a nano-material drying system for preparing PTX @ SN38-NMs, which comprises a machine body group, a warm air module, a filter membrane surface treatment module and a free particle capture module, wherein the warm air module is arranged at the central position inside the machine body group, and acts on the non-interception surface of a filter membrane fixed on the upper end surface of the filter membrane by generating uniform circulating warm air, the filter membrane surface treatment module is a plurality of groups of atomizing nozzles distributed on the upper side of the interception surface of the filter membrane in a surrounding manner, and the free particle capture module is arranged right above the central position of the interception surface of the filter membrane. The invention is provided with the filter membrane surface treatment module, adopts a mode of spraying organic solvent to replace the traditional washing mode, can solve the problem of large organic solvent consumption of the traditional organic solvent washing method for drying the nano particles, and is provided with the free particle capture module, so that the nano particles in a free state in the drying process can be captured, the loss rate of the nano particles in the drying process is reduced, and the acquisition rate of the particles is improved.

Description

Nano material drying system for PTX @ SN38-NMs preparation

Technical Field

The invention relates to the field of nano material preparation, in particular to a nano material drying system for PTX @ SN38-NMs preparation.

Background

Glioma is one of the most lethal and common primary brain tumors, known to affect 0.02% of the population. Although glioblastoma is a rare tumor, its poor survival rate makes it an important health problem. Standard treatment for glioblastoma typically involves post-operative chemotherapy. However, these treatments are not considered effective in controlling the disease, resulting in survival times of less than 15 months. In addition, the resistance and toxic effects of chemotherapeutic drugs suggest that chemotherapy is insufficient to combat the disease. In addition, poor drug permeability due to physiological barriers such as the blood-brain barrier and the blood-brain tumor barrier is another important limitation in therapy. Therefore, it is highly desired to find a novel anticancer drug with low toxicity and high efficacy for effectively treating glioblastoma.

PTX @ SN38-NMs is a novel anti-cancer drug proposed for glioma treatment and related studies have shown that PTX @ SN38-NM is injected intravenously into xenografted LN229 cells. Compared with the free drug (PTX + SN 38), PTX @ SN38-NMs can significantly inhibit tumor development, prolong survival time and reduce side effects, indicating the chemotherapeutic efficiency of the drug delivery system. The particle size of PTX @ SN38-NMs was 27.97. + -. 1.87nm, which required the use of filters to purify the nanomaterial solution during the drug manufacturing process. And drying the filter paper of the filter in a hot air box to obtain PTX @ SN38-NMs, wherein the nano particles on the outer layer surface of the filter membrane are firstly dried along with the drying process, and at the moment, the part of the particles are easy to become free and float in the drying box, so that the medicine loss is caused, and the yield is reduced. In addition, the preparation method of the PTX @ SN38-NMs nanoparticles is a liquid phase method, but the surface energy of the nanoparticles is very large due to the fact that the particle size of the nanoparticles is quite small and the dispersity is very large, so that the nanoparticles are easily agglomerated by a traditional drying method in a drying and water removing step in the preparation process of the liquid phase method. To this end, we propose a nanomaterial drying system for the preparation of PTX @ SN 38-NMs.

Disclosure of Invention

The invention mainly aims to provide a nano material drying system for preparing PTX @ SN38-NMs, which can effectively solve the problems in the background art.

In order to achieve the purpose, the invention adopts the technical scheme that: the utility model provides a nano-material drying system for preparation of PTX @ SN38-NMs, includes organism group, warm braw module, filter membrane surface treatment module and free particle capture module, the warm braw module is installed in organism group's inside central point and is put the department, acts on the non-surface of damming of the filter membrane of fixed up end through producing even circulation warm braw, filter membrane surface treatment module is for surrounding distribution in a plurality of groups atomizer of the surperficial upside that dams of filter membrane, pumps atomizer department with organic solvent pump through pump liquid equipment and infusion pipeline to evenly spray the surface that dams to the filter membrane in the drying process, free particle capture module installs directly over the surperficial central point that dams of filter membrane, and free particle capture module upper end is organized with the organism and is connected.

The free particle capturing module comprises a flow guiding field, an air nozzle, an angle regulator, a capturing field and a capturing plate and is used for capturing nano particles in a free state in the drying process, the flow guiding field and the capturing field are hollow cylindrical devices which are communicated with each other and are arranged in a crenellated mode, the air nozzle is uniformly distributed on the inner walls of the flow guiding field and the capturing field through the angle regulator, and the capturing plate is arranged at the connecting position of the central axis of the capturing field and a machine body group.

Further, the warm braw module includes hot plate, heat pipe, drainage cover, wind-equalizing net, workstation and mount for provide the required heat of nanometer particle stoving, the hot plate is installed in the inside lower terminal surface of organism group, heat pipe one end is connected with the hot plate, and the other end is equipped with the drainage cover, and the tip is connected with the workstation, wind-equalizing net is installed in the pipe wall department of heat pipe and workstation junction, the up end in the workstation is installed to the mount.

Furthermore, catch the board and set up for hollow inverted round platform form, and catch the board bottom surface down and be the magnetic sheet, go up the bottom surface and evenly be equipped with a plurality of hole of airing exhaust.

Further, the organic solvent is a dichloromethane solution.

Further, the operation flow of the drying system is as follows:

setting an initial drying temperature of a warm air module, conveying warm air to a workbench along a heat conduction pipe, uniformly acting on a non-interception surface of a filter membrane at a temperature lower than the boiling point of an organic solvent, pumping the organic solvent into an atomizing nozzle of a filter membrane surface treatment module through a liquid pumping device and a liquid conveying pipeline in an initial drying stage, and uniformly spraying the organic solvent onto a cut-off surface of the filter membrane in a drying process;

step two, measuring the water content of the filter membrane at intervals, and when the measured water content of the filter membrane is less than 10%, adjusting the operating temperature of the warm air module to ensure that the warm air module dries the filter membrane at a boiling point slightly lower than that of the organic solvent until the filter membrane is completely dried;

and step three, adjusting the air nozzle arranged on the inner wall of the diversion field through an angle adjuster to enable the air nozzle to perform air injection operation at a certain angle, so that stable spiral ascending air flow is formed in the diversion field, the nano particles in a free state in the diversion field are guided to the capture field, adjusting the air nozzle arranged on the inner wall of the diversion field through the angle adjuster to enable the air nozzle to perform air injection operation along the tangential direction of the inner wall of the capture field, stable annular air flow is formed in the capture field, and the nano particles in the annular air flow are adsorbed through a magnetic plate at the lower end of the capture plate.

Compared with the prior art, the invention has the following beneficial effects:

(1) the hot air module is used for providing heat required by drying the nano particles, the heating plate generates heat, the heat is conducted to the workbench through the heat conduction pipe, when hot air is transmitted to the air equalizing net, uniform and slow hot air flow is formed to act on the non-throttling surface of the filter membrane, meanwhile, a drainage cover is arranged at the joint of the heat conduction pipe and the workbench, when the temperature of the workbench rises, after the hot air is gathered, partial air flow is discharged from the drainage cover, stable hot air flow is formed, the stability of the temperature in the drying process is kept, the phenomenon that the temperature difference between the upper end surface and the lower end surface of the filter membrane is too large due to overhigh temperature is prevented, and the drying effect is improved;

(2) the filter membrane surface treatment module is arranged, the traditional washing mode is replaced by the organic solvent spraying mode, the organic solvent can be connected with the nano particles on the surface intercepted by the filter membrane in an atomizing mode, the using amount of the organic solvent can be reduced, the problem of high organic solvent consumption in the drying process of the nano particles by the traditional organic solvent washing method is solved, and meanwhile, the parameters such as the atomizing degree, the spraying amount, the spraying time period and the like of the organic solvent can be accurately controlled, so that the organic solvent is fully contacted with the nano particles, and the agglomeration phenomenon of the nano particles in the drying process is reduced;

(3) set up free particle and catch the module, adjust the air nozzle who installs in the drainage field inner wall through the angle regulator, make the air nozzle carry out the jet-propelled operation with certain angle, thereby form stable heliciform updraft in the drainage field, and be the nano particle drainage of free state to the catch field in the drainage field, and form stable annular air current in the catch field, the nano particle in with annular air current is adsorbed through the magnetic sheet of catch plate lower extreme, can catch the nano particle that is free state, reduce the loss rate of stoving in-process nano particle, improve the acquisition rate of particle.

Drawings

FIG. 1 is a schematic view of the overall structure of a drying system according to the present invention;

FIG. 2 is an exploded view of the heater module of the present invention;

FIG. 3 is a schematic view of the distribution structure of the air nozzles in the flow guiding field according to the present invention;

FIG. 4 is a schematic diagram of the distribution structure of the gas nozzles in the capture field according to the present invention;

FIG. 5 is a schematic view of the structure of the capture plate of the present invention.

In the figure: 1. a body group; 2. a warm air module; 21. heating plates; 22. a heat conduction pipe; 23. a drainage cover; 24. a wind equalizing net; 25. a work table; 26. a fixed mount; 3. a filter membrane surface treatment module; 4. a free particle capture module; 41. a flow guiding field; 42. an air nozzle; 43. an angle adjuster; 44. a field of capture; 45. a capture plate.

Detailed Description

The present invention will be further described with reference to the following detailed description, wherein the drawings are for illustrative purposes only and are not intended to be limiting, and certain features of the drawings are omitted, enlarged or reduced in size, and are not intended to represent the actual product size.

Example 1

As shown in fig. 1-2, a nanomaterial drying system for PTX @ SN38-NMs preparation comprises a machine body group 1, a warm air module 2, a filter membrane surface treatment module 3 and a free particle capturing module 4, wherein the warm air module 2 is installed at the central position inside the machine body group 1, and acts on the non-interception surface of the filter membrane fixed on the upper end surface thereof by generating uniform circulating warm air, the filter membrane surface treatment module 3 is a plurality of groups of atomizing nozzles distributed around the interception surface upper side of the filter membrane, an organic solvent is pumped into the atomizing nozzles by a liquid pumping device and a liquid conveying pipeline and is uniformly sprayed to the interception surface of the filter membrane in the drying process, the free particle capturing module 4 is installed right above the interception surface central position of the filter membrane, and the upper end of the free particle capturing module 4 is connected with the machine body group 1.

The free particle capturing module 4 comprises a flow guiding field 41, an air nozzle 42, an angle regulator 43, a capturing field 44 and a capturing plate 45, and is used for capturing nano particles in a free state in the drying process, the flow guiding field 41 and the capturing field 44 are hollow cylindrical devices which are communicated with each other and are provided with crenellations, the air nozzle 42 is uniformly distributed on the inner walls of the flow guiding field 41 and the capturing field 45 through the angle regulator 43, and the capturing plate 45 is arranged at the joint of the central axis of the capturing field 44 and the machine body group 1.

The warm air module 2 comprises a heating plate 21, a heat pipe 22, a flow guide cover 23, an air equalizing net 24, a workbench 25 and a fixing frame 26, and is used for providing heat required by drying nano particles, the heating plate 21 is installed on the lower end face of the inside of the machine body group 1, one end of the heat pipe 22 is connected with the heating plate 21, the other end of the heat pipe is provided with the flow guide cover 23, the end part of the heat pipe is connected with the workbench 25, the air equalizing net 24 is installed on the pipe wall of the joint of the heat pipe 22 and the workbench 25, and the fixing frame 26 is installed on the upper end face of the workbench 25.

By adopting the technical scheme: the warm braw module that sets up is used for providing the required heat of nanometer particle stoving, produce the heat by hot plate 21, and conduct the heat to workstation 25 department through heat pipe 22, when hot-air transfer to wind-uniforming net 24 department, form even slow hot gas flow and act on the non-throttling surface of filter membrane, thereby can slowly dry the filter membrane, be provided with drainage cover 23 in heat pipe 22 and workstation 25 junction simultaneously, temperature rise when workstation 25 department, after the hot-air gathering, some air flow is discharged by drainage cover 23, be favorable to forming stable hot gas flow, keep the stability of stoving in-process temperature, prevent that the high temperature from leading to the filter membrane about the terminal surface difference in temperature too big, improve the stoving effect.

Example 2

The free particle capturing module 4 comprises a flow guiding field 41, an air nozzle 42, an angle regulator 43, a capturing field 44 and a capturing plate 45, and is used for capturing nano particles in a free state in the drying process, the flow guiding field 41 and the capturing field 44 are hollow cylindrical devices which are communicated with each other and are provided with crenellations, the air nozzle 42 is uniformly distributed on the inner walls of the flow guiding field 41 and the capturing field 45 through the angle regulator 43, and the capturing plate 45 is arranged at the joint of the central axis of the capturing field 44 and the machine body group 1. The organic solvent is a dichloromethane solution.

By adopting the technical scheme: in the process of drying the nano particles, three acting forces of nano particle surface energy, liquid tension and nano particle and liquid interface tension exist, the nano particle system forms a stable state, along with continuous volatilization of liquid in the nano particle system, under the combined action of the three acting forces, adjacent nano particle systems start to gradually shrink, after the liquid volatilizes to a certain degree, the nano particles are not filled with the liquid, the balance among the stable systems formed by the three acting forces is broken, a large number of bent liquid surfaces are formed among the particles, additional pressure generated by the bent liquid surfaces causes the shrinkage effect to generate, the adjacent particles are continuously close to each other, the initial interaction bonds among a certain number of nano particles are broken to form new bonds, the particles are aggregated into secondary particles, the surface energy of the particles is reduced, the stable state is formed again, namely the particle aggregation phenomenon, by spraying the organic solvent to the particles in the drying process, in the process of washing the particles, the organic solvent takes away part of water and replaces the water to exist among the particles, so that part of non-bridging hydroxyl groups are replaced by organic functional groups, the formation of the hydroxyl groups is avoided, on the other hand, a certain steric hindrance effect is also achieved, the distance among the particles is increased, and the agglomeration phenomenon of the particles is reduced, the arranged filter membrane surface treatment module 3 is adopted, the organic solvent is pumped into an atomizing nozzle of the filter membrane surface treatment module 3 through a liquid pumping device and a liquid conveying pipeline and is uniformly sprayed to the interception surface of the filter membrane in the drying process, so that the organic solvent can be connected with the nano particles on the interception surface of the filter membrane in an atomizing mode, the use amount of the organic solvent can be reduced, and the problem of large organic solvent consumption in the drying of the nano particles by the traditional organic solvent washing method is solved, meanwhile, parameters such as the atomization degree, the spraying amount and the spraying time period of the organic solvent can be accurately controlled, the organic solvent is in full contact with the nanoparticles, the agglomeration phenomenon of the nanoparticles in the drying process is reduced, dichloromethane is adopted as a flushing solvent, and is favorable for occupying gaps of the nanoparticles after water evaporation, so that a new stable system is formed, and the dichloromethane is an organic compound, the boiling point of the dichloromethane is 39.8 ℃, so that the drying temperature of the system can be controlled at a lower level, and the energy is saved.

Example 3

As shown in fig. 1-4, a nanomaterial drying system for PTX @ SN38-NMs preparation comprises a machine body group 1, a warm air module 2, a filter membrane surface treatment module 3 and a free particle capturing module 4, wherein the warm air module 2 is installed at the central position inside the machine body group 1, and acts on the non-interception surface of a filter membrane fixed on the upper end surface of the filter membrane by generating uniform circulating warm air, the filter membrane surface treatment module 3 is a plurality of groups of atomizing nozzles distributed around the interception surface of the filter membrane, an organic solvent is pumped into the atomizing nozzles by a liquid pumping device and a liquid conveying pipeline and is uniformly sprayed to the interception surface of the filter membrane in a drying process, the free particle capturing module 4 is installed right above the central position of the interception surface of the filter membrane, and the upper end of the free particle capturing module 4 is connected with the machine body group 1.

The warm air module 2 comprises a heating plate 21, a heat pipe 22, a flow guide cover 23, an air equalizing net 24, a workbench 25 and a fixing frame 26, and is used for providing heat required by drying nano particles, the heating plate 21 is installed on the lower end face of the inside of the machine body group 1, one end of the heat pipe 22 is connected with the heating plate 21, the other end of the heat pipe is provided with the flow guide cover 23, the end part of the heat pipe is connected with the workbench 25, the air equalizing net 24 is installed on the pipe wall of the joint of the heat pipe 22 and the workbench 25, and the fixing frame 26 is installed on the upper end face of the workbench 25. The organic solvent is a dichloromethane solution.

By adopting the technical scheme: at the earlier stage of drying operation, the water content of the filter membrane is higher, the water evaporation is quicker, the agglomeration phenomenon among particles is aggravated, the amount of the sprayed organic solvent is increased properly, so that enough organic solvent is filled among the particles, the agglomeration phenomenon is slowed down, the water content of the filter membrane is measured at intervals, the spraying amount of the organic solvent of the filter membrane surface treatment module 3 is adjusted in real time, when the measured water content of the filter membrane is less than 10%, the water content among the particles is at a lower level, the large-amount organic solvent spraying has small effect on preventing the agglomeration phenomenon among the particles, the spraying amount of the organic solvent is reduced by fixing, the operating temperature of the warm air module 2 is adjusted at the same time, so that the warm air module 2 dries the filter membrane at a boiling point slightly lower than that of the organic solvent, at the moment, the water among the particles is continuously evaporated under the continuous action of the warm air module 2, and the organic solvent is also continuously evaporated at a temperature lower than the boiling point, and the boiling phenomenon can not occur, the stable new bond formed by the nano particles in an unstable state is prevented from being broken, and the physical stability among the particles is favorably maintained.

Example 4

As shown in fig. 1-5, a nanomaterial drying system for PTX @ SN38-NMs preparation comprises a machine body group 1, a warm air module 2, a filter membrane surface treatment module 3 and a free particle capturing module 4, wherein the warm air module 2 is installed at the central position inside the machine body group 1, and acts on the non-interception surface of the filter membrane fixed on the upper end surface thereof by generating uniform circulating warm air, the filter membrane surface treatment module 3 is a plurality of groups of atomizing nozzles distributed around the interception surface upper side of the filter membrane, an organic solvent is pumped into the atomizing nozzles by a liquid pumping device and a liquid conveying pipeline and is uniformly sprayed to the interception surface of the filter membrane in the drying process, the free particle capturing module 4 is installed right above the interception surface central position of the filter membrane, and the upper end of the free particle capturing module 4 is connected with the machine body group 1.

Catch plate 45 and set up for hollow inverted round platform form, and catch plate 45 lower bottom surface and be the magnetic sheet, go up the bottom surface and evenly be equipped with a plurality of hole of airing exhaust.

By adopting the technical scheme: at the later stage of the drying operation, the moisture content in the nanoparticles is gradually reduced along with the gradual reduction of the water content of the filter membrane, the nanoparticle layer on the upper layer is firstly dried, in the process of forming new bonds among the nanoparticles, because a new particle system is not stable yet, and the surface energy of the particles is increased under the environment of hot air flow, part of the particles are separated from the original system and are suspended and dried in a free state, at the moment, the air nozzle 42 arranged on the inner wall of the flow guiding field 41 is adjusted by the angle adjuster 43, so that the air nozzle 42 performs air injection operation at a certain angle, stable spiral ascending air flow is formed in the flow guiding field 41, the nanoparticles in the free state in the flow guiding field 41 are guided to the capturing field 44, the air nozzle 42 arranged on the inner wall of the flow guiding field 41 is adjusted by the angle adjuster 43, so that the air nozzle 42 performs air injection operation along the tangential direction of the inner wall of the capturing field 44, stable annular airflow (the dotted arrow in the figure is airflow direction) is formed in the capture field 44, the magnetic plate at the lower end of the capture plate 45 adsorbs the nanoparticles in the annular airflow, and hot airflow flows out from the exhaust holes at the upper bottom surface of the capture plate 45, so that the nanoparticles in a free state can be captured, the loss rate of the nanoparticles in the drying process is reduced, and the particle acquisition rate is improved.

It should be noted that, the present invention is a nanomaterial drying system for PTX @ SN38-NMs preparation, when in use, the initial drying temperature of the warm air module 2 is set, so that warm air is conveyed to the workbench 25 along the heat pipe 22 and uniformly acts on the non-interception surface of the filter membrane at a temperature lower than the boiling point of the organic solvent, in the initial drying stage, the organic solvent is pumped into the atomizing nozzle of the filter membrane surface treatment module 3 through the liquid pumping device and the liquid conveying pipe and uniformly sprayed to the interception surface of the filter membrane in the drying process, the water content of the filter membrane is measured at intervals, when the measured water content of the filter membrane is less than 10%, the operating temperature of the warm air module 2 is adjusted, so that the warm air module 2 dries the filter membrane to be completely dried at a temperature slightly lower than the boiling point of the organic solvent, the air nozzle 42 installed on the inner wall of the guiding flow field 41 is adjusted by the angle adjuster 43, the air nozzle 42 is used for injecting air at a certain angle, so that stable spiral ascending air flow is formed in the drainage field 41, the nano particles in a free state in the drainage field 41 are drained to the capture field 44, the air nozzle 42 arranged on the inner wall of the drainage field 41 is adjusted by the angle adjuster 43, the air nozzle 42 is used for injecting air along the tangential direction of the inner wall of the capture field 44, stable annular air flow is formed in the capture field 44, and the nano particles in the annular air flow are adsorbed by the magnetic plate at the lower end of the capture plate 45.

The foregoing shows and describes the general principles and broad features of the present invention and advantages thereof. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed. The scope of the invention is defined by the appended claims and equivalents thereof.

Claims

1. A nanometer material drying system for PTX @ SN38-NMs preparation comprises a machine body group (1), a warm air module (2), a filter membrane surface treatment module (3) and a free particle capture module (4), and is characterized in that: the hot air module (2) is arranged at the center position inside the machine body group (1), and acts on the non-interception surface of the filter membrane fixed on the upper end surface of the filter membrane by generating uniform circulating hot air, the filter membrane surface treatment module (3) is a plurality of groups of atomizing nozzles distributed on the upper side of the interception surface of the filter membrane in a surrounding manner, an organic solvent is pumped into the atomizing nozzles by pump liquid equipment and a liquid conveying pipeline and is uniformly sprayed to the interception surface of the filter membrane in the drying process, the free particle capture module (4) is arranged right above the center position of the interception surface of the filter membrane, and the upper end of the free particle capture module (4) is connected with the machine body group (1);

the free particle capturing module (4) comprises a flow guiding field (41), an air nozzle (42), an angle regulator (43), a capturing field (44) and a capturing plate (45) and is used for capturing nano particles in a free state in a drying process, the flow guiding field (41) and the capturing field (44) are arranged in a hollow cylindrical shape which is communicated with each other and is used for carrying out crenellation installation, the air nozzle (42) is uniformly distributed on the inner walls of the flow guiding field (41) and the capturing field (45) through the angle regulator (43), and the capturing plate (45) is arranged at the joint of the central axis of the capturing field (44) and the machine body group (1).

2. A nanomaterial drying system for PTX @ SN38-NMs production as claimed in claim 1 wherein: warm braw module (2) are including hot plate (21), heat pipe (22), drainage cover (23), wind-equalizing net (24), workstation (25) and mount (26) for provide the required heat of nanometer particle stoving, hot plate (21) are installed in the inside terminal surface down of organism group (1), heat pipe (22) one end is connected with hot plate (21), and the other end is equipped with drainage cover (23), and the tip is connected with workstation (25), wind-equalizing net (24) are installed in the pipe wall department of heat pipe (22) and workstation (25) junction, mount (26) are installed in the up end of workstation (25).

3. A nanomaterial drying system for PTX @ SN38-NMs production as claimed in claim 1 wherein: catch board (45) and set up for hollow inverted round platform form, and catch board (45) lower bottom surface and be the magnetic sheet, go up the bottom surface and evenly be equipped with a plurality of hole of airing exhaust.

4. A nanomaterial drying system for PTX @ SN38-NMs production as claimed in claim 1 wherein: the organic solvent is dichloromethane solution.

5. A nanomaterial drying system for the preparation of PTX @ SN38-NMs as claimed in any one of claims 1 to 4, wherein: the operation flow of the drying system is as follows:

setting an initial drying temperature of the warm air module (2), conveying warm air to a workbench (25) along a heat conduction pipe (22), uniformly acting on a non-interception surface of a filter membrane at a temperature lower than the boiling point of an organic solvent, pumping the organic solvent into an atomizing nozzle of the filter membrane surface treatment module (3) through liquid pumping equipment and a liquid conveying pipeline in an initial drying stage, and uniformly spraying the organic solvent onto an interception surface of the filter membrane in a drying process;

step two, measuring the water content of the filter membrane at intervals, and when the measured water content of the filter membrane is less than 10%, adjusting the operating temperature of the warm air module (2) to ensure that the warm air module (2) dries the filter membrane at a boiling point slightly lower than that of the organic solvent until the filter membrane is completely dried;

adjusting the air nozzle (42) arranged on the inner wall of the flow guiding field (41) through an angle adjuster (43), enabling the air nozzle (42) to perform air injection operation at a certain angle, so that stable spiral ascending air flow is formed in the flow guiding field (41), guiding the nanoparticles in the flow guiding field (41) in a free state to the capture field (44), adjusting the air nozzle (42) arranged on the inner wall of the flow guiding field (41) through the angle adjuster (43), enabling the air nozzle (42) to perform air injection operation along the tangential direction of the inner wall of the capture field (44), forming stable annular air flow in the capture field (44), and adsorbing the nanoparticles in the annular air flow through a magnetic plate at the lower end of the capture plate (45).