CN114470140A - Traditional Chinese medicine composition for preventing and treating gastric cancer and preparation method and application thereof - Google Patents

Traditional Chinese medicine composition for preventing and treating gastric cancer and preparation method and application thereof Download PDF

Info

Publication number
CN114470140A
CN114470140A CN202210349226.7A CN202210349226A CN114470140A CN 114470140 A CN114470140 A CN 114470140A CN 202210349226 A CN202210349226 A CN 202210349226A CN 114470140 A CN114470140 A CN 114470140A
Authority
CN
China
Prior art keywords
parts
gastric cancer
traditional chinese
chinese medicine
medicine composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN202210349226.7A
Other languages
Chinese (zh)
Other versions
CN114470140B (en
Inventor
杨倩
李佃贵
李博林
杜朋丽
杜姚
张云凤
才艳茹
赵丹阳
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hebei Provincial Hospital Of Traditional Chinese Medicine First Affiliated Hospital Of Hebei University Of Traditional Chinese Medicine
Original Assignee
Hebei Provincial Hospital Of Traditional Chinese Medicine First Affiliated Hospital Of Hebei University Of Traditional Chinese Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hebei Provincial Hospital Of Traditional Chinese Medicine First Affiliated Hospital Of Hebei University Of Traditional Chinese Medicine filed Critical Hebei Provincial Hospital Of Traditional Chinese Medicine First Affiliated Hospital Of Hebei University Of Traditional Chinese Medicine
Priority to CN202210349226.7A priority Critical patent/CN114470140B/en
Publication of CN114470140A publication Critical patent/CN114470140A/en
Application granted granted Critical
Publication of CN114470140B publication Critical patent/CN114470140B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/22—Boron compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/646—Arachnids, e.g. spiders, scorpions, ticks or mites
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/65—Amphibians, e.g. toads, frogs, salamanders or newts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/066—Clavicipitaceae
    • A61K36/068—Cordyceps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/41—Crassulaceae (Stonecrop family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
    • A61K36/704—Polygonum, e.g. knotweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/748—Oldenlandia or Hedyotis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966—Fritillaria, e.g. checker lily or mission bells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/898—Orchidaceae (Orchid family)
    • A61K36/8984—Dendrobium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9064—Amomum, e.g. round cardamom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing and treating gastric cancer and a preparation method and application thereof. The composition comprises the following raw materials: borax, radix Actinidiae chinensis, caulis et folium Vitis Viniferae, fructus Polygoni orientalis, Ficus Pumila fruit, Curcumae rhizoma, herba Hedyotidis Diffusae, periostracum Cicadae, Scorpio, Bulbus Fritillariae Thunbergii, Concha Ostreae, herba Ocimi, fructus Citri Sarcodactylis, rhizoma Pinelliae, Poria, herba Dendrobii, radix Rhodiolae and fructus Amomi rotundus. The Chinese medicinal composition has the effects of resisting cancer, preventing gastric cancer recurrence and metastasis, relieving adverse reaction of operation and radiotherapy and chemotherapy, improving life quality of patients, and prolonging life, and can be used for preparing medicine for preventing gastric cancer and medicine for treating gastric cancer.

Description

Traditional Chinese medicine composition for preventing and treating gastric cancer and preparation method and application thereof
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for preventing and treating gastric cancer and a preparation method and application thereof.
Background
Gastric cancer (gastric carcinoma) is one of the most common malignant tumors of the digestive system, seriously threatens the health level of the masses in China and brings heavy burden to families and society of patients. According to the global cancer statistics in 2018, more than 100 ten thousand new cases of gastric cancer in 2018 are counted, nearly 80 ten thousand deaths are related to the gastric cancer, and Chinese gastric cancer patients almost account for half of the world. As a country with high incidence of gastric cancer, the incidence and mortality of the gastric cancer in malignant tumors are high in the 2 nd place in China. At present, the treatment of the gastric cancer is mainly surgical resection and assisted by chemotherapy, and although western medicine treatment methods are continuously mature and various targeted medicines are continuously available, the treatment effect of the gastric cancer is still not ideal and the mortality rate is high.
Disclosure of Invention
Clinical practices prove that the traditional Chinese medicine composition has the effects of resisting cancer, preventing recurrence and metastasis of gastric cancer, relieving adverse reactions of operation and radiotherapy and chemotherapy and the like, has good curative effects on improving the life quality of patients and prolonging the life time, and can be used for preparing medicines for preventing or treating gastric cancer.
In order to achieve the purpose of the invention, the embodiment of the invention adopts the following technical scheme:
a traditional Chinese medicine composition for preventing and treating gastric cancer comprises the following raw materials in parts by weight: 1-3 parts of borax, 15-30 parts of Chinese actinidia root, 9-15 parts of amur ampelopsis stem, 10-15 parts of fructus polygoni orientalis, 10-20 parts of ficus pumila fruit, 6-9 parts of curcuma zedoary, 15-30 parts of spreading hedyotis herb, 5-8 parts of cicada flower, 3-6 parts of scorpion, 6-10 parts of thunberg fritillary bulb, 10-20 parts of oyster, 10-15 parts of basil, 3-9 parts of fingered citron, 3-9 parts of pinellia ternate, 9-15 parts of poria cocos, 6-12 parts of dendrobium nobile, 6-12 parts of rhodiola rosea and 3-6 parts of amomum cardamomum.
Clinical practice proves that the traditional Chinese medicine composition has the effects of counteracting toxic substances, softening hard masses, eliminating mass, resolving masses, reducing phlegm, dispersing swelling, tonifying qi, harmonizing stomach and nourishing yin, has the effects of resisting cancers, preventing relapse and metastasis of gastric cancer, relieving adverse reactions of operations and chemoradiotherapy and the like, has better curative effects on improving the life quality of patients and prolonging the life cycle, and can fill the defect that the effect of supplementing simple western medicine is not ideal.
In the traditional Chinese medicines of the formula:
borax is sweet, salty and cool in nature; clearing away heat, eliminating phlegm, removing toxic substance and preventing corrosion;
the Chinese actinidia root is sour, astringent and cool; clearing away heat and toxic materials, dispelling pathogenic wind, removing dampness, promoting urination, and stopping bleeding;
the wild grape vine is sweet in taste and mild in nature; clearing heat, stopping bleeding, dispelling wind-damp, preventing miscarriage;
the fructus Polygoni orientalis is salty in taste and slightly cold in nature; dispersing blood stasis, eliminating mass, removing food retention and relieving pain;
ficus pumila fruits are sweet in taste and neutral in nature; tonifying kidney, arresting spontaneous emission, promoting blood circulation, and inducing lactation;
the zedoary is pungent and bitter in flavor and warm in nature; promoting qi circulation, removing blood stasis, resolving food stagnation and relieving pain;
oldenlandia diffusa is slightly bitter and sweet in taste and cold in nature; clearing away heat and toxic materials, removing dampness, and treating stranguria;
the golden cicada fungus is sweet in taste and cold in nature; dispelling wind, clearing heat, arresting convulsion and tranquilizing;
quan Xie is pungent, mild in nature and toxic; calming endogenous wind, relieving spasm, counteracting toxic pathogen, resolving hard mass, dredging collaterals, and relieving pain;
zhejiang fritillaria is bitter in taste and cold in nature; clearing heat, resolving masses, eliminating phlegm and relieving cough;
oyster is salty in taste and slightly cold in nature; heavily tranquilize mind, pacify liver and subdue yang, soften hardness and dissipate nodulation, astringe and astringe;
basil is pungent, sweet and warm in nature; dispelling wind, relieving exterior syndrome, eliminating dampness, regulating the middle warmer, promoting qi and blood circulation, removing toxic substance, and relieving swelling;
the fingered citron is pungent, bitter and sour in taste and warm in nature; soothing liver, regulating qi, harmonizing stomach and relieving pain;
ban Xia is pungent in flavor, warm in nature and toxic; eliminating dampness and phlegm, lowering adverse qi and relieving vomiting, relieving distension and fullness and resolving masses;
poria cocos is sweet and light in flavor and mild in nature; promoting diuresis, eliminating dampness, invigorating spleen, and calming heart;
the dendrobium is sweet in taste and slightly cold in nature; benefiting stomach, promoting fluid production, nourishing yin and clearing heat;
rhodiola root is sweet and bitter in taste and mild in nature; replenishing qi, activating blood circulation, dredging collaterals and relieving asthma;
round cardamom is pungent in flavor and warm in nature; resolve dampness, relieve stuffiness, promote qi circulation, warm middle energizer, stimulate appetite and promote digestion.
In the traditional Chinese medicine composition, the oldenlandia diffusa and the borax are monarch medicines for clearing heat, removing toxicity and relieving swelling; the scorpion removes pathogenic factors from collaterals, the fructus polygoni orientalis and the rhizoma zedoariae break blood and remove stasis, the thunberg fritillary bulb and the oyster soften and dissipate stagnation, and are used as ministerial drugs; the fingered citron liver-soothing and qi-moving, the pinellia ternate, the poria cocos and the amomum cardamomum which have the functions of strengthening the spleen and reducing phlegm, and dehumidifying and resolving hard mass, the dendrobium nobile and the qi-replenishing, the actinidia root and the amur ampelopsis stem which have the functions of clearing heat, detoxicating and detumescence, and the ficus pumila fruit, the cicada flower, the basil and the rhodiola rosea which have the functions of dissipating blood stasis and relieving pain, activating blood and resisting cancer are used as assistant and guide drugs.
Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 1.5-2.5 parts of borax, 15-22 parts of Chinese actinidia root, 10-13 parts of amur ampelopsis stem, 11-13 parts of fructus polygoni orientalis, 12-17 parts of ficus pumila fruit, 7-9 parts of curcuma zedoary, 15-22 parts of spreading hedyotis herb, 5-7 parts of cordyceps sobolifera, 4-6 parts of scorpion, 8-10 parts of thunberg fritillary bulb, 12-17 parts of oyster, 11-13 parts of basil, 5-8 parts of fingered citron, 5-8 parts of pinellia ternate, 10-13 parts of poria cocos, 8-10 parts of dendrobium nobile, 8-10 parts of rhodiola rosea and 4-6 parts of amomum cardamomum.
Preferably, the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 2 parts of borax, 18 parts of Chinese actinidia root, 12 parts of amur ampelopsis stem, 12 parts of fructus polygoni orientalis, 15 parts of ficus pumila fruit, 8 parts of curcuma zedoary, 18 parts of oldenlandia diffusa, 6 parts of golden cicada flower, 5 parts of scorpion, 9 parts of thunberg fritillary bulb, 15 parts of oyster, 12 parts of basil, 6 parts of fingered citron, 6 parts of pinellia ternate, 12 parts of poria cocos, 10 parts of dendrobium, 9 parts of rhodiola rosea and 5 parts of amomum cardamomum.
Preferably, the traditional Chinese medicine composition can also be added with the following raw materials in parts by weight: 3-9 parts of buckeye seeds, 6-9 parts of edible tulip, 5-10 parts of toad skin, 5-9 parts of stiff silkworm and 6-10 parts of common camptotheca fruit.
Semen aesculi is sweet in flavor and warm in nature; regulating qi-flowing, relieving epigastric distention, regulating stomach function and relieving pain;
the edible tulip is sweet in taste, slightly pungent and cool in nature; clearing away heat and toxic materials, eliminating carbuncle, and dispersing pathogenic accumulation;
the toad skin is pungent in flavor, cold in nature and slightly toxic; clearing away heat and toxic materials, promoting diuresis and relieving flatulence;
bombyx Batryticatus is salty and pungent in flavor and neutral in nature; wind-extinguishing and spasm-stopping, wind-dispelling and pain-relieving, phlegm-resolving and mass-resolving;
the camptotheca acuminate fruits are bitter, pungent and cold in nature; clear heat and remove toxicity, dissipate nodulation and eliminate mass.
When the traditional Chinese medicine composition contains the traditional Chinese medicines, the anti-cancer and detumescence effects are further enhanced, the gastric cancer can be more effectively treated, the lump is reduced, the adverse reaction of operation and radiotherapy and chemotherapy is relieved, the tumor metastasis is avoided, or the relapse of postoperative patients is avoided, and meanwhile, the clinical symptoms and the life quality of gastric cancer patients such as stomachache, gastrectasia, anorexia and the like can be remarkably improved. Wherein, the oldenlandia diffusa and the borax are monarch drugs for clearing heat, detoxifying and reducing swelling, and the edible tulip and the toad skin are used for clearing heat, detoxifying, eliminating stagnation and reducing swelling; scorpion and batryticated silkworm are removed and enter the evil of the collateral channel, thunberg fritillary bulb, oyster are softened and dispersed, zedoary, fructus polygoni orientalis and common camptotheca fruit are used for breaking blood and removing stasis, and anticancer and dispersing stasis are used as ministerial drugs; fingered citron and Chinese buckeye fruit are used for soothing the liver and promoting the circulation of qi, pinellia tuber, tuckahoe and amomum cardamomum are used for strengthening the spleen and reducing phlegm, removing dampness and dissipating stagnation, wild grapevine and Chinese gooseberry root are used for clearing heat, detoxicating and reducing swelling, dendrobium is used for nourishing yin and tonifying qi, and rowan, thunderbolt fruit, golden cicada flower and rhodiola rosea are used as adjuvant and guiding drugs for dissipating stasis and relieving pain, and activating blood and resisting cancer.
The composition has strong effects in eliminating phlegm and resolving masses, and especially has good effect in improving symptoms of epigastric fullness and distention.
Preferably, the weight parts of the added raw materials are as follows: 5-8 parts of buckeye seeds, 8-9 parts of edible tulip, 8-10 parts of toad skin, 7-9 parts of stiff silkworm and 8-10 parts of common camptotheca fruit.
Preferably, the weight parts of the added raw materials are as follows: 6 parts of buckeye seeds, 8 parts of Indian iphigenia bulb, 9 parts of toad skin, 8 parts of stiff silkworm and 9 parts of common camptotheca fruit.
In the practical use of the traditional Chinese medicine, 1g of the traditional Chinese medicine is used as each dose, and 1-2 doses are used every day according to the state of illness.
The embodiment of the invention also provides a preparation method of the traditional Chinese medicine composition for preventing and treating gastric cancer, which specifically comprises the following operations: weighing the raw materials according to the raw material proportion of the traditional Chinese medicine composition, mixing, decocting the raw materials except the borax with water, filtering to obtain water decoction, and adding the borax into the water decoction before use.
The preparation method is simple to operate, and in practical application, the borax can be added into the water decoction before use or can be taken after being mixed with the water decoction.
Preferably, the decoction is carried out for 1-2 times, and each time lasts for 30-40 min.
The preparation method of the traditional Chinese medicine composition can also specifically comprise the following operations: weighing the raw materials according to the raw material ratio of the traditional Chinese medicine composition, decocting the raw materials except borax respectively with water, filtering, concentrating, drying, and mixing with borax to obtain the traditional Chinese medicine composition.
The product obtained by the preparation method is a dry product, is convenient to store and transport, and can be dissolved into water to a required concentration in clinical use.
Preferably, the decoction time is 30-40 min.
The preparation method of the Chinese medicinal composition can also be obtained by grinding the raw materials respectively and mixing.
The embodiment of the invention also provides application of the traditional Chinese medicine composition for preventing and treating gastric cancer in preparation of medicines for preventing recurrence and metastasis of gastric cancer.
The Chinese medicinal composition has good effect of preventing gastric cancer recurrence, and can be used for preparing medicine for preventing gastric cancer recurrence and metastasis.
The embodiment of the invention also provides application of the traditional Chinese medicine composition for preventing and treating gastric cancer in preparation of a medicine for treating gastric cancer.
The Chinese medicinal composition has definite curative effect on gastric cancer, can alleviate adverse reaction of operation and radiotherapy and chemotherapy, improve the life quality of patients, and prolong life cycle, so that the Chinese medicinal composition can be used for preparing medicaments for treating gastric cancer.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.
Example 1
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, each dosage of the traditional Chinese medicine composition is prepared from the following raw materials by weight:
2g of borax, 18g of Chinese actinidia root, 12g of amur grape vine, 12g of fructus polygoni orientalis, 15g of ficus pumila fruit, 8g of curcuma zedoary, 18g of spreading hedyotis herb, 6g of cicada flower, 5g of scorpion, 9g of thunberg fritillary bulb, 15g of oyster, 12g of basil, 6g of fingered citron, 6g of pinellia tuber, 12g of poria cocos, 10g of dendrobium, 9g of rhodiola rosea and 5g of amomum cardamomum.
The preparation method comprises the following steps:
grinding different Chinese medicinal decoction pieces respectively by grinding method, and mixing.
Example 2
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, each dosage of the traditional Chinese medicine composition is prepared from the following raw materials by weight:
1.5g of borax, 15g of Chinese actinidia root, 10g of amur ampelopsis stem, 11g of fructus polygoni orientalis, 12g of ficus pumila fruit, 7g of rhizoma zedoariae, 15g of spreading hedyotis herb, 5g of golden cicada flower, 4g of scorpion, 8g of thunberg fritillary bulb, 12g of oyster, 11g of basil, 5g of fingered citron, 5g of pinellia tuber, 10g of poria cocos, 8g of dendrobium, 8g of rhodiola rosea and 4g of amomum cardamomum.
The preparation method is the same as example 1.
Example 3
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, each dosage of the traditional Chinese medicine composition is prepared from the following raw materials by weight:
2.5g of borax, 22g of Chinese actinidia root, 13g of amur ampelopsis stem, 13g of fructus polygoni orientalis, 17g of ficus pumila fruit, 9g of rhizoma zedoariae, 22g of spreading hedyotis herb, 7g of golden cicada flower, 6g of scorpion, 10g of thunberg fritillary bulb, 17g of oyster, 13g of basil, 8g of fingered citron, 8g of pinellia tuber, 13g of poria cocos, 10g of dendrobium, 10g of rhodiola rosea and 6g of amomum cardamomum.
The preparation method is the same as example 1.
Example 4
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, each dosage of the traditional Chinese medicine composition is prepared from the following raw materials by weight:
1g of borax, 15g of Chinese actinidia root, 9g of amur grape vine, 10g of fructus polygoni orientalis, 10g of ficus pumila fruit, 6g of rhizoma zedoariae, 15g of spreading hedyotis herb, 5g of cicada flower, 3g of scorpion, 6g of thunberg fritillary bulb, 10g of oyster, 10g of basil, 3g of fingered citron, 3g of pinellia tuber, 9g of poria cocos, 6g of dendrobium, 6g of rhodiola rosea and 3g of amomum cardamomum.
The preparation method is the same as example 1.
Example 5
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, each dosage of the traditional Chinese medicine composition is prepared from the following raw materials by weight:
3g of borax, 30g of Chinese actinidia root, 15g of amur grape vine, 15g of fructus polygoni orientalis, 20g of ficus pumila fruit, 9g of rhizoma zedoariae, 30g of spreading hedyotis herb, 8g of cicada flower, 6g of scorpion, 10g of thunberg fritillary bulb, 20g of oyster, 15g of basil, 9g of fingered citron, 9g of pinellia tuber, 15g of poria cocos, 12g of dendrobium, 12g of rhodiola rosea and 6g of amomum cardamomum.
The preparation method is the same as example 1.
Example 6
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, which is prepared from the following raw materials in the same manner as in embodiment 1:
decocting the above materials except borax with 6 times of water for 40min, filtering, decocting the residue with 5 times of water for 30min, filtering, mixing filtrates, concentrating, and drying to obtain water-decocted extract. Mixing the water extract of the raw materials with borax.
Example 7
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, which is prepared from the following raw materials in the same manner as in embodiment 2:
decocting the above materials except borax with 6 times of water for 30min, filtering, decocting the residue with 5 times of water for 30min, filtering, mixing filtrates, concentrating, and drying to obtain water-decocted extract. Mixing the water extract of the raw materials with borax.
Example 8
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, which is prepared from the following raw materials in the same manner as in embodiment 3:
decocting the above materials except borax with 7 times of water for 40min, filtering, decocting the residue with 6 times of water for 40min, filtering, mixing filtrates, concentrating, and drying to obtain water-decocted extract. Mixing the water extract of the raw materials with borax.
Example 9
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, which is prepared from the following raw materials in the same way as in embodiment 1:
putting the above materials except borax in a standard Chinese medicinal decoction machine, adding 6 times of water, decocting for 40min, decocting the residue with 5 times of water for 30min, filtering, and mixing filtrates to obtain water decoction; before the application, borax is added into the water decoction, or the water decoction is used for taking the borax by mixing.
Example 10
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, which is prepared from the following raw materials in the same manner as in embodiment 2:
putting the above materials except borax in a standard Chinese medicinal decoction machine, adding 6 times of water, decocting for 30min, decocting the residue with 5 times of water for 30min, filtering, and mixing filtrates to obtain water decoction; before the application, borax is added into the water decoction, or the water decoction is used for taking the borax by mixing.
Example 11
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, which is prepared from the following raw materials in the same manner as in embodiment 3:
placing the above materials except borax in a standard Chinese medicinal decoction machine, adding 7 times of water, decocting for 40min, decocting the residue with 6 times of water for 40min, filtering, and mixing filtrates to obtain water decoction; before the application, borax is added into the water decoction, or the water decoction is used for taking the borax by mixing.
Example 12
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, each dosage of the traditional Chinese medicine composition is prepared from the following raw materials by weight:
2g of borax, 18g of Chinese actinidia root, 12g of amur grape vine, 12g of fructus polygoni orientalis, 15g of ficus pumila fruit, 8g of curcuma zedoary, 18g of spreading hedyotis herb, 6g of cicada flower, 5g of scorpion, 9g of thunberg fritillary bulb, 15g of oyster, 12g of basil, 6g of fingered citron, 6g of pinellia ternate, 12g of poria cocos, 10g of dendrobium, 9g of rhodiola rosea, 5g of amomum cardamomum, 6g of buckeye seed, 8g of edible tulip, 9g of toad skin, 8g of stiff silkworm and 9g of common camptotheca fruit.
The preparation method is the same as example 1.
Example 13
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, each dosage of the traditional Chinese medicine composition is prepared from the following raw materials by weight:
1.5g of borax, 15g of Chinese actinidia root, 10g of ampelopsis grossedentata, 11g of fructus polygoni orientalis, 12g of ficus pumila fruit, 7g of rhizoma zedoariae, 15g of spreading hedyotis herb, 5g of golden cicada flower, 4g of scorpion, 8g of thunberg fritillary bulb, 12g of oyster, 11g of basil, 5g of fingered citron, 5g of pinellia ternata, 10g of poria cocos, 8g of dendrobium, 8g of rhodiola rosea, 4g of amomum cardamomum, 5g of buckeye seed, 8g of edible tulip, 8g of toad skin, 7g of stiff silkworm and 8g of common camptotheca fruit.
The preparation method is the same as example 1.
Example 14
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, each dosage of the traditional Chinese medicine composition is prepared from the following raw materials by weight:
2.5g of borax, 22g of Chinese actinidia root, 13g of ampelopsis grossedentata, 13g of fructus polygoni orientalis, 17g of ficus pumila fruit, 9g of rhizoma zedoariae, 22g of spreading hedyotis herb, 7g of golden cicada flower, 6g of scorpion, 10g of thunberg fritillary bulb, 17g of oyster, 13g of basil, 8g of fingered citron, 8g of pinellia ternata, 13g of poria cocos, 10g of dendrobium, 10g of rhodiola rosea, 6g of amomum cardamomum, 8g of buckeye seed, 9g of edible tulip, 10g of toad skin, 9g of stiff silkworm and 10g of common camptotheca fruit.
The preparation method is the same as example 1.
Example 15
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, each dosage of the traditional Chinese medicine composition is prepared from the following raw materials by weight:
1g of borax, 15g of Chinese actinidia root, 9g of amur grape vine, 10g of fructus polygoni orientalis, 10g of ficus pumila fruit, 6g of rhizoma zedoariae, 15g of spreading hedyotis herb, 5g of golden cicada flower, 3g of scorpion, 6g of thunberg fritillary bulb, 10g of oyster, 10g of basil, 3g of fingered citron, 3g of pinellia ternate, 9g of poria cocos, 6g of dendrobium, 6g of rhodiola rosea, 3g of amomum cardamomum, 3g of buckeye seed, 6g of edible tulip, 5g of toad skin, 5g of stiff silkworm and 6g of common camptotheca fruit.
The preparation method is the same as example 1.
Example 16
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, each dosage of the traditional Chinese medicine composition is prepared from the following raw materials by weight:
3g of borax, 30g of Chinese actinidia root, 15g of ampelopsis grossedentata, 15g of fructus polygoni orientalis, 20g of ficus pumila fruit, 9g of rhizoma zedoariae, 30g of spreading hedyotis herb, 8g of cicada flower, 6g of scorpion, 10g of thunberg fritillary bulb, 20g of oyster, 15g of basil, 9g of fingered citron, 9g of pinellia ternate, 15g of poria cocos, 12g of dendrobium, 12g of rhodiola rosea, 6g of amomum cardamomum, 9g of buckeye seed, 9g of edible tulip, 10g of toad skin, 9g of stiff silkworm and 10g of common camptotheca fruit.
The preparation method is the same as example 1.
Example 17
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, which is prepared from the following raw materials in the same manner as in embodiment 12:
decocting the above materials except borax with 6 times of water for 40min, filtering, decocting the residue with 5 times of water for 30min, filtering, mixing filtrates, concentrating, and drying to obtain water-decocted extract. Mixing the water extract of the raw materials with borax.
Example 18
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, which is prepared from the following raw materials in the same manner as in embodiment 13:
decocting the above materials except borax with 6 times of water for 30min, filtering, decocting the residue with 5 times of water for 30min, filtering, mixing filtrates, concentrating, and drying to obtain water-decocted extract. Mixing the water extract of the raw materials with borax.
Example 19
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, which is prepared from the following raw materials in the same manner as in embodiment 14:
decocting the above materials except borax with 7 times of water for 40min, filtering, decocting the residue with 6 times of water for 40min, filtering, mixing filtrates, concentrating, and drying to obtain water-decocted extract. Mixing the water extract of the raw materials with borax.
Example 20
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, which is prepared from the following raw materials in the same manner as in embodiment 12:
putting the above materials except borax in a standard Chinese medicinal decoction machine, adding 6 times of water, decocting for 40min, decocting the residue with 5 times of water for 30min, filtering, and mixing filtrates to obtain water decoction; before the application, borax is added into the water decoction. For oral administration, borax may be administered with the water decoction.
Example 21
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, which is prepared from the following raw materials in the same manner as in embodiment 13:
putting the above materials except borax in a standard Chinese medicinal decoction machine, adding 6 times of water, decocting for 30min, decocting the residue with 5 times of water for 30min, filtering, and mixing filtrates to obtain water decoction; before the application, borax is added into the water decoction. For oral administration, borax may be administered with the water decoction.
Example 22
The embodiment of the invention provides a traditional Chinese medicine composition for preventing and treating gastric cancer, which is prepared from the following raw materials in the same manner as in embodiment 14:
placing the above materials except borax in a standard Chinese medicinal decoction machine, adding 7 times of water, decocting for 40min, decocting the residue with 6 times of water for 40min, filtering, and mixing filtrates to obtain water decoction; before the application, borax is added into the water decoction. For oral administration, borax may be administered with the water decoction.
Example 23
The embodiment of the invention provides a medicine for preventing relapse and metastasis of gastric cancer. The active ingredients of the medicament are the traditional Chinese medicine composition in the embodiment 1. The composition is administered orally with boiled water 2 times daily in the morning and evening.
Example 24
The embodiment of the invention provides a medicine for preventing relapse and metastasis of gastric cancer. The active ingredient of the medicament is the traditional Chinese medicine composition in the example 6. The composition is administered orally with boiled water 2 times daily in the morning and evening.
Example 25
The embodiment of the invention provides a medicine for preventing relapse and metastasis of gastric cancer. The active ingredient of the medicament is the traditional Chinese medicine composition in example 9. The application method comprises decocting Borax with water, 2 times daily, and administering in the morning and evening.
Example 26
The embodiment of the invention provides a medicine for preventing relapse and metastasis of gastric cancer. The active ingredient of the medicament is the traditional Chinese medicine composition in example 12. The composition is administered orally with boiled water 2 times daily in the morning and evening.
Example 27
The embodiment of the invention provides a medicine for preventing relapse and metastasis of gastric cancer. The active ingredient of the medicament is the traditional Chinese medicine composition in example 17. The composition is administered orally with boiled water 2 times daily in the morning and evening.
Example 28
The embodiment of the invention provides a medicine for preventing relapse and metastasis of gastric cancer. The active ingredient of the medicament is the traditional Chinese medicine composition in example 20. The application method comprises decocting Borax with water, 2 times daily, and administering in the morning and evening.
Example 29
The embodiment of the invention provides a medicine for treating gastric cancer. The active ingredients of the medicament are the traditional Chinese medicine composition in the example 1. The composition is administered orally with boiled water 2 times daily in the morning and evening.
Example 30
The embodiment of the invention provides a medicine for treating gastric cancer. The active ingredient of the medicament is the traditional Chinese medicine composition in the embodiment 6. The composition is administered orally with boiled water 2 times daily in the morning and evening.
Example 31
The embodiment of the invention provides a medicine for treating gastric cancer. The active ingredient of the medicament is the traditional Chinese medicine composition in example 9. The application method comprises decocting Borax with water, 2 times daily, and administering in the morning and evening.
Example 32
The embodiment of the invention provides a medicine for treating gastric cancer. The active ingredient of the medicament is the traditional Chinese medicine composition in example 12. The composition is administered orally with boiled water 2 times daily in the morning and evening.
Example 33
The embodiment of the invention provides a medicine for treating gastric cancer. The active ingredient of the medicament is the traditional Chinese medicine composition in example 17. The composition is administered orally with boiled water 2 times daily in the morning and evening.
Example 34
The embodiment of the invention provides a medicine for treating gastric cancer. The active ingredient of the medicament is the traditional Chinese medicine composition in example 20. The application method comprises decocting Borax with water, 2 times daily, and administering in the morning and evening.
Effect example 1
The effect example provides the statistical result of the clinical application effect of the traditional Chinese medicine composition for treating gastric cancer in the embodiment 6 of the invention.
Clinical data of postoperative chemotherapy gastric cancer patients
1. Source of case
In 2014 1-2014 12, 20 and 20 gastric cancer patients have nausea and vomiting with different degrees and 18 patients have leucopenia with different degrees, wherein the gastric cancer patients are treated by postoperative chemotherapy and treated by hospitals in traditional Chinese medicine in Hebei province, and the age of the gastric cancer patients ranges from 35 to 76 years old.
2. Method of treatment
The Chinese medicinal composition for treating gastric cancer in example 6 of the present invention was administered orally, one dose a day.
3. Results
After 7 doses of the traditional Chinese medicine composition for treating gastric cancer in example 6 of the present invention were taken, the average nausea and vomiting of 20 patients was reduced for 2.6 days (4.1 days are generally required without any medicine), and the average leukocyte recovery time was 7.8 days.
(II) clinical data of gastric cancer patients who have undergone radical surgery
1. Source of case
36 patients who have undergone radical treatment are treated in traditional Chinese medicine hospital of Hebei province in 2014 1-2014 12, and the age is 40-65 years.
2. Method of treatment
The Chinese medicinal composition for treating gastric cancer in example 6 of the present invention was administered orally, one dose a day.
3. Results
By taking 60 doses of the traditional Chinese medicine composition for treating gastric cancer in the embodiment 6 of the invention, the follow-up patients have the average survival time of 63 months and do not relapse or transfer.
Effect example 2
The effect example provides a statistical result of the clinical application effect of the traditional Chinese medicine composition for treating gastric cancer in example 17 of the present invention.
Clinical data of postoperative chemotherapy gastric cancer patients
1. Source of case
The patients with the gastric cancer treated by the chemotherapy after the operation, who visit a hospital in traditional Chinese medicine in Hebei province in 2019 and 12 months in 2019, have the age of 39-74 years, 25 patients with the gastric cancer have nausea and vomiting with different degrees in 25 cases, and have leucopenia with different degrees in 24 cases.
2. Method of treatment
The Chinese medicinal composition for treating gastric cancer in example 17 of the present invention was administered orally, one dose a day.
3. Results
After 7 doses of the traditional Chinese medicine composition for treating gastric cancer in example 17 of the present invention were taken, the average nausea and vomiting of 25 patients was reduced for 2.1 days (4.1 days are generally required without any medicine), and the average leukocyte recovery time was 7.5 days.
(II) clinical data of gastric cancer patients who have undergone radical surgery
1. Source of case
27 patients with gastric cancer who had undergone radical surgery who were hospitalized in the TCM hospital in Hebei province from 1 month to 2015 month 12, wherein the age of the patients is 45-60 years.
2. Method of treatment
The Chinese medicinal composition for treating gastric cancer in example 17 of the present invention was administered orally, one dose a day.
3. Results
By taking 30 doses of the traditional Chinese medicine composition for treating gastric cancer in the embodiment 17 of the invention, the follow-up patients have an average survival time of 64 months and do not have relapse or metastasis.
Effect example 3
The effect example provides an individual case of clinical application of the traditional Chinese medicine composition for treating gastric cancer in example 9 of the present invention.
Lie, male, 46 years old, bank clerk. The patient is diagnosed in outpatient clinic of traditional Chinese medicine for the conservative treatment of traditional Chinese medicine by radical operation treatment and chemotherapy after the patient finds that the gastric abscess is caused by 2015 physical examination, and the patient has stable illness after the visit of 5 years, wherein 90 doses of the traditional Chinese medicine composition for treating the gastric cancer in the embodiment 9 are orally taken.
Effect example 4
The effect example provides an individual case of clinical application of the traditional Chinese medicine composition for treating gastric cancer in the embodiment of the invention.
Case 1:
liu Gong, male, age 58, Shijiazhuang city, Hebei province, retired. The patient is diagnosed with the malignant tumor of the stomach in 2020, and has stable postoperative condition after the gastrectomy because the gastric cavity is full of the gastric fullness in a certain three hospitals. In 2021, the physician needs to take the treatment of the stomach cancer to improve the symptoms because of the fullness of the stomach cavity and the influence on food intake in 2 months, and then goes to the clinic of traditional Chinese medicine. After 14 doses of the traditional Chinese medicine composition in the embodiment 17 of the invention are given, the symptoms of the gastric cavity fullness of the patient are obviously improved, the general condition of the patient can be improved by adding, subtracting and recuperating the prescription for more than three months, and the gastric cavity fullness and the food intake are obviously improved.
Case 2
Sunzhi, male, 72 years old, Hebei province, and prefecture. In 2017, the patient is diagnosed as the gastric malignant tumor (signet ring cell carcinoma) in a county hospital due to the intermittent pain of the gastric cavity, the patient does not know himself, the symptoms of the patient can be improved through the conservative treatment in the county hospital, the patient is refused to perform the operation treatment by family members, and the patient is diagnosed in a traditional Chinese medicine outpatient service in order to control the disease condition in traditional Chinese medicine. After 14 doses of the traditional Chinese medicine composition in the embodiment 20 of the invention are given, the patient is in a good state, the patient is maintained for more than half a year by adding or subtracting the formula, no other discomfort is caused except intermittent epigastric pain, the patient can follow up for 1 year again, and the disease condition is stable.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents or improvements made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims (9)

1. The traditional Chinese medicine composition for preventing and treating gastric cancer is characterized by comprising the following raw materials in parts by weight: 1-3 parts of borax, 15-30 parts of Chinese actinidia root, 9-15 parts of amur ampelopsis stem, 10-15 parts of fructus polygoni orientalis, 10-20 parts of ficus pumila fruit, 6-9 parts of curcuma zedoary, 15-30 parts of spreading hedyotis herb, 5-8 parts of cicada flower, 3-6 parts of scorpion, 6-10 parts of thunberg fritillary bulb, 10-20 parts of oyster, 10-15 parts of basil, 3-9 parts of fingered citron, 3-9 parts of pinellia ternate, 9-15 parts of poria cocos, 6-12 parts of dendrobium nobile, 6-12 parts of rhodiola rosea and 3-6 parts of amomum cardamomum.
2. The traditional Chinese medicine composition for preventing and treating gastric cancer according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 1.5-2.5 parts of borax, 15-22 parts of Chinese actinidia root, 10-13 parts of amur ampelopsis stem, 11-13 parts of fructus polygoni orientalis, 12-17 parts of ficus pumila fruit, 7-9 parts of curcuma zedoary, 15-22 parts of spreading hedyotis herb, 5-7 parts of cordyceps sobolifera, 4-6 parts of scorpion, 8-10 parts of thunberg fritillary bulb, 12-17 parts of oyster, 11-13 parts of basil, 5-8 parts of fingered citron, 5-8 parts of pinellia ternate, 10-13 parts of poria cocos, 8-10 parts of dendrobium nobile, 8-10 parts of rhodiola rosea and 4-6 parts of amomum cardamomum.
3. The traditional Chinese medicine composition for preventing and treating gastric cancer according to claim 2, which is characterized by comprising the following raw materials in parts by weight: 2 parts of borax, 18 parts of Chinese actinidia root, 12 parts of amur ampelopsis stem, 12 parts of fructus polygoni orientalis, 15 parts of ficus pumila fruit, 8 parts of curcuma zedoary, 18 parts of oldenlandia diffusa, 6 parts of golden cicada flower, 5 parts of scorpion, 9 parts of thunberg fritillary bulb, 15 parts of oyster, 12 parts of basil, 6 parts of fingered citron, 6 parts of pinellia ternate, 12 parts of poria cocos, 10 parts of dendrobium, 9 parts of rhodiola rosea and 5 parts of amomum cardamomum.
4. The traditional Chinese medicine composition for preventing and treating gastric cancer according to any one of claims 1 to 3, which is characterized by further comprising the following raw materials in parts by weight: 3-9 parts of buckeye seeds, 6-9 parts of edible tulip, 5-10 parts of toad skin, 5-9 parts of stiff silkworm and 6-10 parts of common camptotheca fruit.
5. The traditional Chinese medicine composition for preventing and treating gastric cancer as claimed in claim 4, further comprising the following raw materials in parts by weight: 5-8 parts of buckeye seeds, 8-9 parts of edible tulip, 8-10 parts of toad skin, 7-9 parts of stiff silkworm and 8-10 parts of common camptotheca fruit.
6. The traditional Chinese medicine composition for preventing and treating gastric cancer as claimed in claim 5, further comprising the following raw materials in parts by weight: 6 parts of buckeye seeds, 8 parts of Indian iphigenia bulb, 9 parts of toad skin, 8 parts of stiff silkworm and 9 parts of common camptotheca fruit.
7. The preparation method of the traditional Chinese medicine composition for preventing and treating gastric cancer is characterized by comprising the following operations: weighing the raw materials according to the raw material proportion of the traditional Chinese medicine composition of any one of claims 1 to 6, mixing, decocting the raw materials except borax with water, filtering to obtain water decoction, and adding borax into the water decoction before use; or
Weighing the raw materials according to the raw material proportion of the traditional Chinese medicine composition of any one of claims 1 to 6, respectively decocting the raw materials except borax with water, filtering, concentrating, drying, and mixing with borax to obtain the traditional Chinese medicine composition; or
Weighing the raw materials according to the ratio of the raw materials of the traditional Chinese medicine composition of any one of claims 1 to 6, respectively grinding the raw materials into fine powder, and mixing the fine powder to obtain the traditional Chinese medicine composition.
8. The use of the Chinese medicinal composition for preventing and treating gastric cancer according to any one of claims 1 to 6 or the Chinese medicinal composition prepared by the preparation method according to claim 7 in the preparation of medicaments for preventing recurrence and metastasis of gastric cancer.
9. The use of the Chinese medicinal composition for preventing and treating gastric cancer according to any one of claims 1 to 6 or the Chinese medicinal composition prepared by the preparation method according to claim 7 in the preparation of medicaments for treating gastric cancer.
CN202210349226.7A 2022-04-01 2022-04-01 Traditional Chinese medicine composition for preventing and treating gastric cancer as well as preparation method and application thereof Active CN114470140B (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202210349226.7A CN114470140B (en) 2022-04-01 2022-04-01 Traditional Chinese medicine composition for preventing and treating gastric cancer as well as preparation method and application thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210349226.7A CN114470140B (en) 2022-04-01 2022-04-01 Traditional Chinese medicine composition for preventing and treating gastric cancer as well as preparation method and application thereof

Publications (2)

Publication Number Publication Date
CN114470140A true CN114470140A (en) 2022-05-13
CN114470140B CN114470140B (en) 2023-05-12

Family

ID=81488050

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202210349226.7A Active CN114470140B (en) 2022-04-01 2022-04-01 Traditional Chinese medicine composition for preventing and treating gastric cancer as well as preparation method and application thereof

Country Status (1)

Country Link
CN (1) CN114470140B (en)

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101954048A (en) * 2010-10-15 2011-01-26 胡一莉 Chinese medicinal formula for treating atrophic gastritis and precancerous lesion
CN103520653A (en) * 2013-10-25 2014-01-22 李琳 Traditional Chinese medicine composition for treating gastric cancer
CN105288462A (en) * 2015-10-24 2016-02-03 四川聚豪生物科技有限公司 Traditional Chinese medicine composition effective in gastric cancer treatment and preparation method of traditional Chinese medicine composition effective in gastric cancer treatment
CN106177806A (en) * 2016-08-25 2016-12-07 刘常生 A kind of Chinese medicine formula treating gastric cancer
CN109846992A (en) * 2017-11-30 2019-06-07 肖桂珍 A kind of seedling medicine for treating gastric cancer
CN111643637A (en) * 2020-07-06 2020-09-11 河北省中医院 Traditional Chinese medicine composition for preventing and treating chronic atrophic gastritis and gastric precancerous lesions and preparation method and application thereof

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101954048A (en) * 2010-10-15 2011-01-26 胡一莉 Chinese medicinal formula for treating atrophic gastritis and precancerous lesion
CN103520653A (en) * 2013-10-25 2014-01-22 李琳 Traditional Chinese medicine composition for treating gastric cancer
CN105288462A (en) * 2015-10-24 2016-02-03 四川聚豪生物科技有限公司 Traditional Chinese medicine composition effective in gastric cancer treatment and preparation method of traditional Chinese medicine composition effective in gastric cancer treatment
CN106177806A (en) * 2016-08-25 2016-12-07 刘常生 A kind of Chinese medicine formula treating gastric cancer
CN109846992A (en) * 2017-11-30 2019-06-07 肖桂珍 A kind of seedling medicine for treating gastric cancer
CN111643637A (en) * 2020-07-06 2020-09-11 河北省中医院 Traditional Chinese medicine composition for preventing and treating chronic atrophic gastritis and gastric precancerous lesions and preparation method and application thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
张曦文等: "花宝金运用抗癌解毒药对治疗肿瘤经验探析", 《辽宁中医杂志》 *
石芳等: "基于数据挖掘的刘启泉教授诊治胃癌临床经验研究", 《现代中西医结合杂志》 *

Also Published As

Publication number Publication date
CN114470140B (en) 2023-05-12

Similar Documents

Publication Publication Date Title
CN102327544A (en) Traditional Chinese medicinal composition for treating cancer
CN102861193B (en) Traditional Chinese medicine composition for treating gastric cancer
CN113730535A (en) Traditional Chinese medicine composition for treating lung cancer and preparation method and application of traditional Chinese medicine preparation of traditional Chinese medicine composition
CN101543616B (en) Traditional Chinese medicine composition for preventing and treating tumor and its preparation method
CN103417911B (en) Traditional Chinese medicine composition for supporting chemo-treatment
CN114470140A (en) Traditional Chinese medicine composition for preventing and treating gastric cancer and preparation method and application thereof
CN104258260B (en) A kind of saline cistanche alcohol extracting thing, preparation method and its usage
CN112168947A (en) Traditional Chinese medicine composition for treating pneumonia and preparation method thereof
CN114588240B (en) Traditional Chinese medicine composition for treating colorectal cancer and preparation method and application thereof
CN105521246A (en) Medicinal preparation for treating lung cancer and applications of medicinal preparation
CN114558101A (en) Traditional Chinese medicine composition for preventing and treating digestive tract tumor and preparation method and application thereof
CN104524277A (en) Traditional Chinese medicine mixture for treating anorexia nervosa
CN113144103B (en) Traditional Chinese medicine composition for clearing throat and application thereof
CN105396020A (en) Preparation method of pharmaceutical powder alleviating tumor patient radiotherapy reaction
CN108159232B (en) Traditional Chinese medicine preparation for reducing postoperative recurrence and metastasis of colorectal cancer and preparation method and application thereof
CN1256976C (en) Anti-cancer Chinese medicinal composition and its preparing method
CN108635498B (en) Pharmaceutical composition for treating myelodysplastic syndrome and application thereof
CN106924483B (en) Traditional Chinese medicine compound preparation for treating leukemia caused by spleen-kidney yang deficiency and preparation method thereof
CN107362296B (en) Medicine for treating benign tumor of skin and preparation method thereof
CN106822594B (en) Traditional Chinese medicine compound preparation for treating leukemia caused by excessive toxic heat and preparation method thereof
CN105456951A (en) Traditional Chinese medicine preparation for treating breast fibroadenoma and preparing method of traditional Chinese medicine preparation
CN105012642A (en) Preparation method of traditional Chinese medicine composition capable of promoting blood circulation to remove blood stasis, and stopping bleeding and relieving pain
CN113975238A (en) Calcium supplementing tablet with spleen invigorating and digestion promoting functions
CN114869987A (en) A Chinese medicinal composition for preventing and treating hepatocarcinoma
CN117860850A (en) Traditional Chinese medicine composition for improving advanced lung cancer and preparation method thereof

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant