CN114470131A - Preparation method of nano silver turmeric material applied to inhibiting novel coronavirus - Google Patents
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Abstract
The invention provides a preparation method of a nano-silver turmeric material for inhibiting novel coronavirus, which comprises the steps of heating turmeric powder, stirring, mixing with a silver nitrate solution, cooling and stirring for multiple times, reacting, centrifuging and the like to obtain a nano-silver turmeric crude extract; and after the procedures of washing, centrifuging and the like are carried out for a plurality of times, obtaining the purified nano silver turmeric composition. The nano-silver turmeric composition can be applied to inhibiting novel coronavirus and similar viruses and can be used as a drug source for preventing and treating novel coronavirus COVID-19 derived diseases in the future.
Description
Technical Field
The invention provides a preparation method of a nano-silver turmeric material for inhibiting a novel coronavirus, and relates to the technical field of preparation of a nano-silver turmeric material which can be used for inhibiting the virus and can be used for preventing and treating a novel coronavirus COVID-19 derived disease in the future.
Background
According to the Google network data, a new coronavirus (COVID-19) with high infectivity smelling color change recently is shown to have been diagnosed by 10, 11 days of 2020 in the world by 3730 million people, and up to 107 million people are infected with diseases and died, and the number is still in continuous and rapid rising.
Coronaviruses (Coronavirus [ CoV ]) are a group of RNA viruses with an outer mantle (envelope), and are named because projections resembling phaleria macrocarpa are visible under an electron microscope. Coronaviruses have become the causes of severe acute respiratory diseases, and from severe acute respiratory syndrome coronaviruses (SARS-CoV) in 2003, middle east respiratory syndrome coronaviruses (MERS-CoV) in 2013, to SARS-CoV-2 which is a pandemic that seriously endangers the world now in 2019, they were named as novel coronaviruses COVID-19 by the world health organization. This phenomenon contributes to the rapid development of resistance and vaccine failure of RNA viruses due to their high mutation rate. AIDS (AIDS) is RNA virus which is a famous human disease, and no vaccine for treating AIDS exists so far because of the high mutation property of the RNA virus.
Based on long-term research on application of nano-silver and turmeric, the inventor finds that the nano-silver combined with turmeric can inhibit viruses.
The nano silver has antibacterial effect, antifungal and antiviral properties and is widely researched as well as silver compounds, and can be used in fabrics, wound dressings and medical appliances. The nano-silver antibacterial agent shows effectiveness to gram-positive bacteria and gram-negative bacteria, and the literature records that nano-silver has good antibacterial effect to bacteria through in vitro experiments, such as methicillin-resistant staphylococcus aureus (MRSA), Escherichia coli (Escherichia coli), Pseudomonas aeruginosa (Pseudomonas aeruginosa), Vibrio cholerae (Vibrio cholerae) and Bacillus subtilis (Bacillus subtilis) to the antibacterial bacteria. The nano silver also has good bacteriostatic effect on fungi such as Aspergillus niger (Aspergillus niger) and Candida albicans (Candida albicans). The same nanosilver also exhibits excellent antiviral effects against various viruses, such as HIV (Human immunodeficiency Virus), RSV (Respiratory tract fusion Virus), Tacarib (TCRV), herpes simplex Virus of the first type (HSV-1), Monkeypox Virus (Monkeypox Virus), and Hepatitis B Virus (HBV). Therefore, the nano silver is broad-spectrum and multi-mechanism to inhibit and kill bacteria, viruses and the like, and can destroy the activities of DNA, RNA, protein and the like of the viruses by destroying the virus mantle and kill the viruses, and even if the viruses mutate, the virus killing characteristics of the nano silver are not influenced. For the nanosilver to interact effectively with the virus, the nanosilver particles need to be significantly smaller than the virus, e.g. less than 10nm, or most preferably less than 10nm, and most preferably in the range of 3nm to 7nm, as long as the virus is sufficiently covered by the nanosilver particles, the virus function will be disturbed.
As for Turmeric (the academic name of Curcuma longa L, the english name of Turmeric), Curcumin (Curcumin, the molecular formula of C21H20O6), a compound composed of elements such as carbon (C), hydrogen (H), and oxygen (O), is an active ingredient. Curcumin has been approved by the U.S. Food and Drug Administration (FDA) for over 300 clinical trials reporting beneficial protective effects of curcumin on a variety of diseases including inflammatory diseases, neurological diseases, cardiovascular diseases, pulmonary diseases, metabolic diseases, liver diseases, and cancer. However, a large number of studies have shown that turmeric and curcumin are resistant to various viruses, such as aids Virus (HIV), Influenza Virus (inflenza Virus), Herpes simplex Virus of the first and second types (Herpes simplex Virus, HSV-1 and HSV-2), Coxsackievirus (Coxsackievirus), Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), Human papilla Virus (Human papioma Virus, HPV), Japanese Encephalitis Virus (JEV) and Human T-lymphotropic Virus-type (Human T-lymphotropic Virus 1, HTLV-1), so that turmeric and curcumin have shown a large number of evidence of inhibition of various viral infections.
The nano silver and the turmeric are used for preparation, so that the nano silver and the turmeric can be applied to inhibiting novel coronavirus and similar viruses and can be used as a drug source for preventing and treating novel coronavirus COVID-19 derived diseases in the future.
Disclosure of Invention
The invention provides a preparation method of a nano-silver turmeric material for inhibiting novel coronavirus, which is mainly used for improving and lightening the impact of the novel coronavirus COVID-19 on the global human health and economy, breaking through the bottleneck of preventing and treating diseases derived from the novel coronavirus by human at present, and is a biological nano-material mainly comprising turmeric and taking nano-silver as an assistant. The medicine for inhibiting the novel coronavirus COVID-19 is designed and manufactured, so that the problem that the curcumin is unstable, is not easy to dissolve in water and is difficult to absorb by a human body is solved, the problem of biostimulation caused by independently using the nano silver is solved, a medicine source for preventing and treating diseases derived from the novel coronavirus in the future is designed and manufactured, the medicine for effectively and safely inhibiting the novel coronavirus COVID-19 is provided, the problem that the novel coronavirus cannot be completely treated by a vaccine or other related treatment schemes in the future due to the high mutation rate of the novel coronavirus at present is solved, and the global human health and economic problems caused by the novel coronavirus are further improved.
In order to achieve the above object, the specific preparation method of the present invention comprises the following steps performed in sequence:
the method comprises the following steps: mixing turmeric powder with deionized water; step two: heating to boiling; step three: cooling and stirring; step four: mixing silver nitrate solution;
step five: cooling and stirring for reaction; step six: centrifuging; step seven: taking out the supernatant; step eight: centrifuging the supernatant; step nine: collecting the precipitate to obtain crude extract of Curcuma rhizome; step ten: adding deionized water, oscillating at high speed, mixing and cleaning; step eleven: centrifuging; step twelve: collecting the precipitate;
step thirteen: repeatedly cleaning and centrifuging; fourteen steps: obtaining the purified nano-silver turmeric composition.
In a preferred embodiment, in the first step, 5 g of turmeric powder is weighed and 500 ml of deionized water is poured.
In a preferred embodiment, in the second step, the deionized water mixed with turmeric powder in the first step is heated to boiling for 5 minutes.
In a preferred embodiment, the liquid in the second step is slowly stirred after being cooled in the third step, and the temperature range is 75-85 ℃, and is preferably 85 ℃.
In a preferred embodiment, 5 ml of 1mmol silver nitrate solution is slowly added in step four while stirring in step three.
In a preferred embodiment, in the fifth step, the temperature of the liquid in the fourth step is reduced to 45-55 ℃, preferably 50 ℃, and the reaction is terminated after slowly stirring for 24 hours.
In a preferred embodiment, the precipitate impurities are removed by centrifugation at 3000rpm for 10 minutes at 4 ℃ using a high-speed centrifuge.
In a preferred embodiment, in the seventh step, the liquid after centrifugation in the sixth step is taken out, and the supernatant liquid with the impurities of the precipitate removed is taken out; in step eight, the supernatant from step seven was centrifuged at 14000rpm for 1 hour at 4 ℃ in a high speed centrifuge.
In a preferred embodiment, the precipitate is collected in the ninth step, and the precipitate is crude extract of nano silver turmeric; in the tenth step, 50 ml of deionized water is added, and the crude extract of the nano-silver turmeric is mixed and washed at high speed.
In one preferred embodiment, the crude extract of the silver nano turmeric in the eleventh step is centrifuged at 14000rpm for 1 hour at 4 ℃ in a high speed centrifuge; in the twelfth step, the precipitate in the eleventh step is collected; in the thirteenth step, washing and centrifuging are repeated for many times on the precipitate of the twelfth step at 14000rpm at 4 ℃ by using a high-speed centrifuge to remove residual silver nitrate.
Drawings
The present invention will be described in further detail with reference to the accompanying drawings and specific embodiments.
FIG. 1 is a block diagram of the process flow of the present invention
Description of the reference numerals
S1 deionized water mixed turmeric powder
S2 heating to boil
S3 stirring while cooling
S4 Mixed silver nitrate solution
S5 reaction by cooling and stirring
S6 centrifuging
S7 taking out supernatant
S8 centrifuging the supernatant
S9 collecting the precipitate to obtain crude extract of Curcuma rhizome containing nanometer silver
S10 deionized water is added for high-speed oscillation mixing cleaning
S11 centrifuging
S12 collecting the precipitate
S13 repeated washing centrifugation
S14 obtaining the purified nano-silver turmeric composition.
Detailed Description
The technical solution in the embodiments of the present invention is clearly and completely described below with reference to the drawings in the embodiments of the present invention. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention, but the present invention may be practiced in other ways than those specifically described and will be readily apparent to those of ordinary skill in the art without departing from the spirit of the present invention, and therefore the present invention is not limited to the specific embodiments disclosed below.
Referring to fig. 1, the preparation method of the nano-silver turmeric material of the present invention includes the following steps in sequence:
the method comprises the following steps: mixing turmeric powder with deionized water; step two: heating to boiling; step three: cooling and stirring; step four: mixing silver nitrate solution;
step five: cooling and stirring for reaction; step six: centrifuging; step seven: taking out the supernatant; step eight: centrifuging the supernatant; step nine: collecting the precipitate to obtain crude extract of Curcuma rhizome; step ten: adding deionized water, oscillating at high speed, mixing and cleaning; step eleven: centrifuging; step twelve: collecting the precipitate;
step thirteen: repeatedly cleaning and centrifuging; fourteen steps: obtaining the purified nano-silver turmeric composition.
Wherein, in the first step, 5 g of turmeric powder is weighed and poured into 500 ml of deionized water; in the second step, the deionized water mixed with the turmeric powder in the first step is heated to boiling, and the time after boiling is preferably 5 minutes; in the third step, the liquid in the second step is slowly stirred after being cooled, the temperature range is 75-85 ℃, and the optimal temperature is 85 ℃; in the fourth step, 5 ml of 1mmol silver nitrate solution is slowly added while stirring; in the fifth step, the temperature of the liquid in the fourth step is reduced to 45-55 ℃, the temperature is optimally 50 ℃, and the reaction is finished after the liquid is slowly stirred for 24 hours; centrifuging at 4 deg.C and 3000rpm for 10 min by using high-speed centrifuge to remove precipitate impurities; in the seventh step, taking out the liquid after centrifugation in the sixth step, and taking out the supernatant liquid with the sediment impurities removed; in the eighth step, the supernatant obtained in the seventh step is centrifuged at 14000rpm for about 1 hour at 4 ℃ by using a high-speed centrifuge; collecting precipitate in the ninth step, wherein the precipitate is the crude extract of the nano silver turmeric; adding 50 ml of deionized water into the step ten, oscillating at high speed, mixing and cleaning the crude extract of the nano-silver turmeric; in the eleventh step, the crude extract of the nano-silver turmeric is centrifuged for 1 hour at 14000rpm at 4 ℃ by using a high-speed centrifuge; in the twelfth step, the precipitate in the eleventh step is collected; in the thirteenth step, the precipitate in the twelfth step is centrifuged at 14000rpm for 1 hour at 4 ℃ in a high-speed centrifuge, and the washing and centrifuging are repeated for a plurality of times, for example, 10 times, so as to remove residual silver nitrate; finally, a fourteen step is to obtain a purified nano-Silver turmeric composition (Silver-nanocurcin).
The nanometer Silver turmeric composition (Silver-nanocurcin) can be mixed with pure water to obtain nasal spray. Or mixing with various solid or liquid to form powdery, liquid or colloidal antiviral and antibacterial products.
It should be added that the normal use of nano silver in human body is not safe. Since the human body normally ingests silver from food and water every day, the human body has a normal mechanism for dealing with metabolizing silver, with the silver content in most foods being in the range of 10-100 mug/kg. While the biological half-life of silver element in human liver varies from several days to 50 days, most of the absorbed silver will be excreted together with bile in the feces. Therefore, nano silver does not accumulate permanently in human tissue.
After the research of the inventor, the nano-Silver turmeric (Silver-nanocurcin) can be used for preventing the infection of a novel coronavirus COVID-19 in a healthy human body; the nano silver turmeric is sprayed into the nasal cavity through the nasal spray, viruses can be killed in the nasal cavity within a certain time, and the nano silver turmeric is sprayed for a plurality of times a day to enable the local part of the nasal cavity to be provided with the nano silver turmeric within a plurality of hours, so that the viruses can be killed and cells can be prevented from being infected.
The nano-Silver turmeric composition (Silver-nanocurcin) prepared by the invention can be applied to inhibiting novel coronavirus and similar viruses and serving as a drug source for preventing and treating the novel coronavirus COVID-19 derivative diseases in the future, is a biological antiviral material, is tasteless, harmless and nontoxic, has no irritation to organisms, can be applied to the cleaning, disinfecting, sterilizing and antivirus effects of conventional sanitary products of tables, masks, door handles, mobile phones, elevator keys and other articles, and can also be applied to medical disinfection, wound healing, subsequent medicine research and development applications of influenza virus, enterovirus and the like, food processing and disinfection, disinfection of fresh fruits and vegetables, disinfection of frozen foods and cosmetic sanitary operation; air sanitization can also be performed in enclosed spaces (e.g., aircraft, vehicles, ships, skyscrapers, any central air conditioning facility) to reduce the content of COVID-19 aerosol in the air, thereby reducing the speed and capacity of COVID-19 delivery.
It is to be understood that the described embodiments are merely a few embodiments of the invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Claims (10)
1. The preparation method of the nano-silver turmeric material for inhibiting the novel coronavirus is characterized by comprising the following steps in sequence: the method comprises the following steps: mixing turmeric powder with deionized water; step two: heating to boiling; step three: cooling and stirring; step four: mixing silver nitrate solution;
step five: cooling and stirring for reaction; step six: centrifuging; step seven: taking out the supernatant; step eight: centrifuging the supernatant; step nine: collecting the precipitate to obtain crude extract of Curcuma rhizome; step ten: adding deionized water, oscillating at high speed, mixing and cleaning; step eleven: centrifuging; step twelve: collecting the precipitate;
step thirteen: repeatedly cleaning and centrifuging; fourteen steps: obtaining the purified nano-silver turmeric composition.
2. The method for preparing nano-silver turmeric material for inhibiting new coronavirus according to claim 1, wherein in the first step, 5 g of turmeric powder is weighed and 500 ml of deionized water is poured.
3. The method for preparing nano-silver turmeric material for inhibiting new coronavirus according to claim 2, wherein in the second step, the deionized water mixed with turmeric powder in the first step is heated to boiling for 5 minutes.
4. The method for preparing nano-silver turmeric material for inhibiting novel coronavirus according to claim 3, wherein the liquid obtained in the second step is stirred after being cooled, and the temperature range is 75-85 ℃.
5. The method for preparing nano-silver turmeric material for inhibiting a novel coronavirus according to claim 4, wherein 5 ml of 1mmol of silver nitrate solution is added while stirring in step three in step four.
6. The method for preparing nano-silver turmeric material for inhibiting novel coronavirus according to claim 5, wherein in the fifth step, the temperature of the liquid in the fourth step is reduced to 45-55 ℃, and the reaction is terminated after stirring for 24 hours.
7. The method for preparing nano-silver turmeric material for inhibiting novel coronavirus according to claim 6, wherein the precipitate impurities are removed by centrifugation at 3000rpm for 10 minutes at 4 ℃ in the sixth step.
8. The method for preparing nano-silver turmeric material for inhibiting a novel coronavirus according to claim 7, wherein in the seventh step, a supernatant from which impurities of the precipitate have been removed is taken out from the liquid after centrifugation in the sixth step; in step eight, the supernatant from step seven was centrifuged at 14000rpm for 1 hour at 4 ℃ in a centrifuge.
9. The method for preparing nano-silver turmeric material for inhibiting new coronavirus according to claim 8, wherein the precipitate is collected in the ninth step, and the precipitate is a coarse extract of nano-silver turmeric; in the tenth step, 50 ml of deionized water is added, shaken, mixed and washed to obtain the crude extract of the nano-silver turmeric.
10. The method of preparing nano-silver turmeric material for inhibiting a novel coronavirus according to claim 9, wherein the step eleven is to centrifuge the silver nano turmeric crude extract using a centrifuge at 14000rpm for 1 hour at 4 ℃; in the twelfth step, the precipitate in the eleventh step is collected; in the thirteenth step, washing and centrifugation were repeated several times using a centrifuge at 14000rpm at 4 ℃ for the precipitate of the twelfth step to remove residual silver nitrate.
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2020
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| US20200229411A1 (en) * | 2016-08-21 | 2020-07-23 | Insectergy, Llc | Insect production systems and methods |
| CN106880593A (en) * | 2017-02-21 | 2017-06-23 | 中国医学科学院放射医学研究所 | It is a kind of while nano antibacterial agent of loading nano silvery and curcumin and preparation method and application |
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| CN111408733A (en) * | 2020-04-24 | 2020-07-14 | 安信生物科技有限公司 | Antibacterial and antiviral nano silver colloidal solution and preparation method and application thereof |
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| VIVEK KUMAR SONI: "Curcumin, a traditional spice component, can hold the promise against COVID-19?", 《EUROPEAN JOURNAL OF PHARMACOLOGY》 * |
| 向冬喜: "纳米银抗病毒作用的研究进展", 《大连医科大学学报》 * |
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Application publication date: 20220513 |