CN114470083A - Traditional Chinese medicine preparation for promoting fracture healing and preparation method thereof - Google Patents
Traditional Chinese medicine preparation for promoting fracture healing and preparation method thereof Download PDFInfo
- Publication number
- CN114470083A CN114470083A CN202210236713.2A CN202210236713A CN114470083A CN 114470083 A CN114470083 A CN 114470083A CN 202210236713 A CN202210236713 A CN 202210236713A CN 114470083 A CN114470083 A CN 114470083A
- Authority
- CN
- China
- Prior art keywords
- parts
- preparation
- traditional chinese
- fracture
- powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003814 drug Substances 0.000 title claims abstract description 77
- 208000010392 Bone Fractures Diseases 0.000 title claims abstract description 69
- 206010017076 Fracture Diseases 0.000 title claims abstract description 64
- 238000002360 preparation method Methods 0.000 title claims abstract description 42
- 230000001737 promoting effect Effects 0.000 title claims abstract description 28
- 230000035876 healing Effects 0.000 title claims abstract description 25
- 229940079593 drug Drugs 0.000 claims abstract description 35
- 240000008067 Cucumis sativus Species 0.000 claims abstract description 27
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 claims abstract description 27
- 239000000463 material Substances 0.000 claims abstract description 27
- 240000002791 Brassica napus Species 0.000 claims abstract description 20
- 235000004977 Brassica sinapistrum Nutrition 0.000 claims abstract description 20
- 239000004863 Frankincense Substances 0.000 claims abstract description 20
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims abstract description 18
- 235000006226 Areca catechu Nutrition 0.000 claims abstract description 18
- 235000003717 Boswellia sacra Nutrition 0.000 claims abstract description 18
- 240000007551 Boswellia serrata Species 0.000 claims abstract description 18
- 235000012035 Boswellia serrata Nutrition 0.000 claims abstract description 18
- 240000004824 Trimezia steyermarkii Species 0.000 claims abstract description 18
- 239000009136 dragon's blood Substances 0.000 claims abstract description 18
- 244000020518 Carthamus tinctorius Species 0.000 claims abstract description 17
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims abstract description 17
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims abstract description 17
- 241000123589 Dipsacus Species 0.000 claims abstract description 17
- 244000131316 Panax pseudoginseng Species 0.000 claims abstract description 17
- 235000003181 Panax pseudoginseng Nutrition 0.000 claims abstract description 17
- 229910052802 copper Inorganic materials 0.000 claims abstract description 17
- 239000010949 copper Substances 0.000 claims abstract description 17
- 241000213006 Angelica dahurica Species 0.000 claims abstract description 15
- 235000009847 Cucumis melo var cantalupensis Nutrition 0.000 claims abstract description 13
- 244000037364 Cinnamomum aromaticum Species 0.000 claims abstract description 7
- 235000014489 Cinnamomum aromaticum Nutrition 0.000 claims abstract description 7
- 241000208688 Eucommia Species 0.000 claims abstract description 7
- 244000235603 Acacia catechu Species 0.000 claims abstract description 6
- 240000000031 Achyranthes bidentata Species 0.000 claims abstract description 6
- 241000131329 Carabidae Species 0.000 claims abstract description 6
- 244000241257 Cucumis melo Species 0.000 claims abstract 4
- 239000000843 powder Substances 0.000 claims description 34
- 241000112528 Ligusticum striatum Species 0.000 claims description 15
- 239000002994 raw material Substances 0.000 claims description 12
- 238000000034 method Methods 0.000 claims description 11
- 238000003756 stirring Methods 0.000 claims description 8
- 239000011248 coating agent Substances 0.000 claims description 6
- 238000000576 coating method Methods 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 239000002775 capsule Substances 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 4
- 239000007788 liquid Substances 0.000 claims description 4
- 241000427159 Achyranthes Species 0.000 claims description 3
- 238000004140 cleaning Methods 0.000 claims description 3
- 238000005516 engineering process Methods 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 238000004806 packaging method and process Methods 0.000 claims description 3
- 238000003825 pressing Methods 0.000 claims description 3
- 238000007789 sealing Methods 0.000 claims description 3
- 238000007873 sieving Methods 0.000 claims description 3
- 230000001954 sterilising effect Effects 0.000 claims description 3
- 238000009210 therapy by ultrasound Methods 0.000 claims description 3
- 238000005303 weighing Methods 0.000 claims description 3
- 235000001287 Guettarda speciosa Nutrition 0.000 claims description 2
- 239000002131 composite material Substances 0.000 claims 2
- 241000125175 Angelica Species 0.000 claims 1
- 235000008216 herbs Nutrition 0.000 claims 1
- 238000010907 mechanical stirring Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 abstract description 5
- 208000024779 Comminuted Fractures Diseases 0.000 abstract description 4
- 244000189799 Asimina triloba Species 0.000 abstract description 3
- 235000006264 Asimina triloba Nutrition 0.000 abstract description 3
- 235000009467 Carica papaya Nutrition 0.000 abstract description 3
- 240000007311 Commiphora myrrha Species 0.000 abstract description 3
- 235000006965 Commiphora myrrha Nutrition 0.000 abstract description 3
- 235000007265 Myrrhis odorata Nutrition 0.000 abstract description 3
- 230000004044 response Effects 0.000 abstract description 3
- 241000212322 Levisticum officinale Species 0.000 abstract description 2
- 239000001645 levisticum officinale Substances 0.000 abstract description 2
- 229940126680 traditional chinese medicines Drugs 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 16
- 244000080767 Areca catechu Species 0.000 description 12
- 244000064895 Cucumis melo subsp melo Species 0.000 description 9
- 210000000988 bone and bone Anatomy 0.000 description 8
- 210000003414 extremity Anatomy 0.000 description 8
- 230000036407 pain Effects 0.000 description 8
- 230000009467 reduction Effects 0.000 description 8
- 230000008961 swelling Effects 0.000 description 7
- 231100000252 nontoxic Toxicity 0.000 description 6
- 230000003000 nontoxic effect Effects 0.000 description 6
- 230000000052 comparative effect Effects 0.000 description 4
- 210000001364 upper extremity Anatomy 0.000 description 4
- 208000027418 Wounds and injury Diseases 0.000 description 3
- 231100000460 acute oral toxicity Toxicity 0.000 description 3
- 230000017531 blood circulation Effects 0.000 description 3
- 230000000857 drug effect Effects 0.000 description 3
- 210000003205 muscle Anatomy 0.000 description 3
- 239000011505 plaster Substances 0.000 description 3
- 241000717739 Boswellia sacra Species 0.000 description 2
- 206010012289 Dementia Diseases 0.000 description 2
- 208000012661 Dyskinesia Diseases 0.000 description 2
- 206010016970 Foot fracture Diseases 0.000 description 2
- 206010061599 Lower limb fracture Diseases 0.000 description 2
- 206010062575 Muscle contracture Diseases 0.000 description 2
- 241001057584 Myrrha Species 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000004369 blood Anatomy 0.000 description 2
- 235000021152 breakfast Nutrition 0.000 description 2
- 208000006111 contracture Diseases 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 244000237330 gutta percha tree Species 0.000 description 2
- 238000003384 imaging method Methods 0.000 description 2
- 208000014674 injury Diseases 0.000 description 2
- 201000000585 muscular atrophy Diseases 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000009286 sanguis draxonis Substances 0.000 description 2
- 210000000582 semen Anatomy 0.000 description 2
- 239000010959 steel Substances 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 238000001291 vacuum drying Methods 0.000 description 2
- 244000061520 Angelica archangelica Species 0.000 description 1
- 206010005963 Bone formation increased Diseases 0.000 description 1
- 241001489978 Eupolyphaga Species 0.000 description 1
- 102000009123 Fibrin Human genes 0.000 description 1
- 108010073385 Fibrin Proteins 0.000 description 1
- BWGVNKXGVNDBDI-UHFFFAOYSA-N Fibrin monomer Chemical compound CNC(=O)CNC(=O)CN BWGVNKXGVNDBDI-UHFFFAOYSA-N 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 235000002710 Ilex cornuta Nutrition 0.000 description 1
- 241001310146 Ilex cornuta Species 0.000 description 1
- 206010058031 Joint adhesion Diseases 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 208000032912 Local swelling Diseases 0.000 description 1
- 241001608711 Melo Species 0.000 description 1
- 235000009811 Momordica charantia Nutrition 0.000 description 1
- 240000001910 Momordica cochinchinensis Species 0.000 description 1
- 235000009812 Momordica cochinchinensis Nutrition 0.000 description 1
- 235000018365 Momordica dioica Nutrition 0.000 description 1
- 208000006670 Multiple fractures Diseases 0.000 description 1
- 235000010326 Osmanthus heterophyllus Nutrition 0.000 description 1
- 235000003143 Panax notoginseng Nutrition 0.000 description 1
- 241000180649 Panax notoginseng Species 0.000 description 1
- 206010039203 Road traffic accident Diseases 0.000 description 1
- 208000002847 Surgical Wound Diseases 0.000 description 1
- 208000031294 Upper limb fractures Diseases 0.000 description 1
- 201000004810 Vascular dementia Diseases 0.000 description 1
- 206010052428 Wound Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 235000021270 cold food Nutrition 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 229950003499 fibrin Drugs 0.000 description 1
- 238000005469 granulation Methods 0.000 description 1
- 230000003179 granulation Effects 0.000 description 1
- 210000000281 joint capsule Anatomy 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 230000005906 menstruation Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 210000004911 serous fluid Anatomy 0.000 description 1
- 210000004872 soft tissue Anatomy 0.000 description 1
- 235000021259 spicy food Nutrition 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 210000002435 tendon Anatomy 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000017423 tissue regeneration Effects 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 231100000041 toxicology testing Toxicity 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 235000014101 wine Nutrition 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/889—Arecaceae, Palmae or Palmaceae (Palm family), e.g. date or coconut palm or palmetto
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/63—Arthropods
- A61K35/64—Insects, e.g. bees, wasps or fleas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/324—Boswellia, e.g. frankincense
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/32—Burseraceae (Frankincense family)
- A61K36/328—Commiphora, e.g. mecca myrrh or balm of Gilead
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Physical Education & Sports Medicine (AREA)
- Insects & Arthropods (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Animal Husbandry (AREA)
- Inorganic Chemistry (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine preparation for promoting fracture healing, which comprises dragon's blood, ground beetle, pseudo-ginseng, frankincense, myrrh, Chinese angelica, szechuan lovage rhizome, safflower, himalayan teasel root, native copper, raw rapeseed, muskmelon seed, cucumber seed, catechu and guiding drug, wherein the guiding drug is radix polygoni multiflori/cassia twig/eucommia bark/achyranthes bidentata and pawpaw; the traditional Chinese medicine composition has the greatest characteristics of low cost (all the used traditional Chinese medicinal materials are common medicinal materials), greatly lightening the economic burden of patients, and being proved by a large number of actual patients to have quick response, and patients with slight bone fracture can be cured within one to two treatment courses (7-14 days); patients with fracture and comminuted fracture can be cured after three to four courses of treatment (slight difference according to age), and the time for the patients to lie in bed is greatly reduced.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine preparation for promoting fracture healing and a preparation method thereof.
Background
Fracture refers to the continuous complete or partial breakdown of bone structure. It is common to children and the elderly, and occurs in the middle-aged and young. Patients often have one site fractured and a few multiple fractures. After timely and proper treatment, most patients can recover the original functions, and a few patients can leave sequelae with different degrees.
The typical manifestations of fracture patients are local deformation after injury, abnormal movement of limbs, etc., and bone rubbing sound audible when moving limbs. In addition, the wound is extremely painful, the local swelling and congestion may cause dyskinesia after injury.
The ultimate goal of treating fractures is to maximize the recovery of function of the injured limb. Therefore, in fracture treatment, three basic principles of reduction, fixation and functional exercise are very important. The reduction is to restore the fracture end which is displaced after the fracture to be normal or close to the original anatomical relationship so as to restore the support function of the skeleton. Methods of reduction include closed reduction and surgical reduction. After fracture reduction, because of instability, the fracture is easy to be relocated, so that the fracture needs to be fixed at a satisfactory position by adopting different methods to ensure that the fracture is gradually healed. Common fixation methods are: small splints, plaster bandages, external fixing supports, traction, braking and fixing and the like, and the fixing methods are called external fixing. If the fixation is performed by surgical incision with steel plate, steel needle, intramedullary needle, screw, etc., the internal fixation is called. Functional exercise: the blood circulation of tissues around the fracture is increased through the contraction of the muscle of the injured limb, the healing of the fracture is promoted, the muscular atrophy is prevented, and the joint adhesion, the joint capsule contracture and the like are prevented through the active or passive movement of the unfixed joint, so that the function of the injured limb is restored to the normal state before the fracture as soon as possible.
The affected limb of the patient is fixed for a long time, the backflow of the vein and the lymph is not smooth, the serous fluid in the joint cavity is fibrously exuded and the fibrin is deposited, the fibrous adhesion is generated, and the contracture of soft tissues around the joint is accompanied, so that the joint movement is obstructed, the complication of the muscular atrophy and the like is accompanied, and the recovery of the fracture of the patient is seriously influenced.
Therefore, the traditional Chinese medicine preparation for promoting fracture healing speed, having good treatment effect on the old and no side effect at all, and having clinical significance of the traditional Chinese medicine for treating the fracture is developed.
Disclosure of Invention
In order to solve the problems, the invention provides the traditional Chinese medicine preparation for promoting fracture healing and the preparation method thereof, which have low cost and greatly reduce the economic burden of patients. Quick action and slight bone fracture. Can be cured after one to two treatment courses. Patients with fracture and comminuted fracture can be cured after three to four courses of treatment; greatly reducing the time of the patient lying in bed.
In order to achieve the purpose, the invention adopts the technical scheme that: a traditional Chinese medicine preparation for promoting fracture healing is prepared from the following raw materials in parts by weight: 20-30 parts of dragon's blood, 25-30 parts of ground beetle, 15-20 parts of pseudo-ginseng, 12-17 parts of frankincense, 12-14 parts of powder medicine, 20-30 parts of angelica, 10-16 parts of ligusticum wallichii, 10-14 parts of safflower, 15-20 parts of dipsacus root, 30-35 parts of native copper, 12-17 parts of raw rapeseed, 50-60 parts of muskmelon seed, 55-60 parts of cucumber seed, 12-16 parts of catechu and 15-20 parts of guiding drug, wherein the guiding drug is high-yield/cassia twig/eucommia bark/achyranthes bidentatae.
Further, the feed is prepared from the following raw materials in parts by weight: 26 parts of dragon's blood, 28 parts of ground beeltle, 17 parts of pseudo-ginseng, 15 parts of frankincense, 16 parts of powder, 25 parts of Chinese angelica, 14 parts of ligusticum wallichii, 12 parts of safflower, 17 parts of dipsacus root, 33 parts of native copper, 15 parts of raw rapeseed, 55 parts of muskmelon seed, 58 parts of cucumber seed, 14 parts of catechu and 15 parts of guiding drug, wherein the guiding drug is Gaoyan/cassia twig/eucommia bark/achyranthes bidentata.
A preparation method of a traditional Chinese medicine preparation for promoting fracture healing comprises the following steps: weighing dragon's blood, ground beetle, pseudo-ginseng, frankincense, powder medicine, Chinese angelica, ligusticum wallichii, safflower, dipsacus root, native copper, raw rapeseed, muskmelon seed, cucumber seed, catechu and guiding medicine according to the weight part ratio, removing moldy Chinese medicinal materials, cleaning the Chinese medicinal materials, drying and reserving for later use;
step 2: frying the raw rapeseed, the cucumber seed and the cucumber seed treated in the step (1) to be cooked and cooling to room temperature for later use;
and step 3: respectively grinding the cleaned and dried dragon's blood, ground beeltle, pseudo-ginseng, frankincense, powder, Chinese angelica, ligusticum wallichii, safflower, dipsacus root, native copper, catechu and guiding drug in the step 1, as well as the fried and cooled raw rapeseed, cucumber seed and cucumber seed in the step 2 into powder, sieving, and respectively sealing and packaging in independent vessels;
and 4, step 4: and (4) taking the traditional Chinese medicine raw material powder out of each independent vessel in the step (3) to be mixed, and uniformly stirring to prepare mixed medicinal material powder.
Further, in step 1, all the Chinese medicinal materials are cleaned, placed into a dryer, subjected to vacuum drying at 60 ℃ for 12 hours, and then cooled to room temperature.
Further, in step 3, each Chinese medicinal material is ground by a grinder, and each Chinese medicinal material is sieved by a 120-mesh filter screen.
Further, in step 4, mechanically stirring at a stirring speed of 300r/min for 10min, and performing ultrasonic treatment by using an ultrasonic wall breaking technology to obtain mixed medicinal material powder.
Further comprises step 5, drying and sterilizing the mixed medicinal powder at high temperature, and preparing into coated tablets or capsules or oral liquid.
Further, the preparation method of the coated tablet in step 5 is as follows: pressing the mixed medicinal powder into tablet, coating with Opadry AMB coating solution with concentration of 5% at flow rate of 0.25-0.28kg/min, core temperature of 50-55 deg.C, and rotation speed of 7-9 r/min. . The invention has the beneficial effects that: 1. the combination of dragon's blood, pseudo-ginseng, frankincense, myrrh, Chinese angelica, safflower, catechu and ligusticum wallichii has the functions of relieving swelling and pain, promoting blood circulation and removing blood stasis, the combination of native copper, ground beeltle, muskmelon seed, raw rapeseed, cucumber seed and dipsacus root has the functions of relaxing muscles and tendons and setting bones, and the combination of dragon's blood, frankincense and myrrh also has the effect of promoting tissue regeneration.
2. In the invention, different guiding drugs can be adopted as auxiliary drugs according to different fracture parts to enhance the drug effect, wherein the guiding drugs for head fracture are as follows: high cost; the guiding drugs at the upper limb part are: ramulus Cinnamomi; the guiding drug for the chest and the waist is as follows: eucommia ulmoides; the leg guiding drugs are as follows: achyranthis radix; the foot guiding drugs are as follows: achyranthis radix and fructus Chaenomelis.
3. The traditional Chinese medicine composition has the greatest characteristics of low cost (all the used traditional Chinese medicinal materials are common medicinal materials), greatly lightening the economic burden of patients, and being proved by a large number of actual patients to have quick response, and patients with slight bone fracture can be cured within one to two treatment courses (7-14 days); patients with fracture and comminuted fracture can be cured after three to four courses of treatment (slight difference according to age), and the time for the patients to lie in bed is greatly reduced.
Detailed Description
The first embodiment is as follows:
the patient has head fracture, so the adopted guiding drugs are high in cost;
therefore, in the embodiment, the invention provides a traditional Chinese medicine preparation for promoting fracture healing, which is prepared from the following raw materials in parts by weight: 26 parts of dragon's blood, 28 parts of ground beeltle, 17 parts of pseudo-ginseng, 15 parts of frankincense, 16 parts of powder drug, 25 parts of Chinese angelica, 14 parts of ligusticum wallichii, 12 parts of safflower, 17 parts of dipsacus root, 33 parts of native copper, 15 parts of raw rapeseed, 55 parts of muskmelon seed, 58 parts of cucumber seed, 14 parts of catechu and 15 parts of radix stephaniae.
Meanwhile, the embodiment also provides a preparation method of the traditional Chinese medicine preparation for promoting fracture healing,
step 1: weighing dragon's blood, ground beetle, pseudo-ginseng, frankincense, powder medicine, Chinese angelica, ligusticum wallichii, safflower, dipsacus root, native copper, raw rapeseed, muskmelon seed, cucumber seed, catechu and radix polygoni multiflori in parts by weight, removing moldy Chinese medicinal materials, cleaning the Chinese medicinal materials, drying and reserving for later use; in the step 1, all the Chinese medicinal materials are cleaned and put into a dryer, vacuum drying is carried out at 60 ℃ for 12h, and then cooling is carried out to room temperature.
Step 2: frying the raw rapeseed, the cucumber seed and the cucumber seed treated in the step (1) to be cooked and cooling to room temperature for later use;
and step 3: respectively grinding the cleaned and dried dragon's blood, ground beeltle, pseudo-ginseng, frankincense, powder, Chinese angelica, szechuan lovage rhizome, safflower, dipsacus root, native copper, catechu and Chinese holly root in the step 1 and the fried and cooled raw rapeseed, cucumber seed and cucumber seed in the step 2 into powder, sieving, and respectively sealing and packaging in independent vessels; in step 3, each Chinese medicinal material is ground by a grinder, and each Chinese medicinal material is sieved by a 120-mesh filter screen.
And 4, step 4: and (4) taking the traditional Chinese medicine raw material powder out of each independent vessel in the step (3) to be mixed, and uniformly stirring to prepare mixed medicinal material powder. In step 4, mechanically stirring at a stirring speed of 300r/min for 10min, and performing ultrasonic treatment by using an ultrasonic wall breaking technology to obtain mixed medicinal material powder.
The administration method in this embodiment is:
the medicine is taken half an hour before breakfast and half an hour after supper, twice a day and 7 days as a treatment course. The medicine is taken for 1-4 courses. The treatment time is calculated according to the severity of the illness state of the patient. The slight bone fracture can be cured after one treatment course. After the single fracture is reset, the fracture can be cured after 2 treatment courses, and the fracture of the patient with more fractures and older age (more than 65 years old) can be cured after 4 treatment courses.
Contraindications are as follows: the patients are prohibited to take raw or cold food, spicy food and wine during the administration period. The diabetic patients are forbidden to use for hyperosteogeny patients, and the female patients are forbidden to use during menstruation.
Wherein sanguis Draxonis, Notoginseng radix, Olibanum, Myrrha, radix Angelicae sinensis, Carthami flos, Catechu, and rhizoma Ligustici Chuanxiong are used in combination, and have effects of relieving swelling and pain, promoting blood circulation and removing blood stasis, Pyritum, Eupolyphaga Seu Steleophaga, semen melo, semen Brassicae campestris, cucumber seed, and radix Dipsaci are used in combination to have effects of relieving rigidity of muscles and setting bone, and sanguis Draxonis, Olibanum, Myrrha are used in combination to also have effects of promoting granulation.
In the invention, different guiding drugs can be adopted as auxiliary drugs to enhance the drug effect according to different fracture parts, wherein the guiding drugs for head fracture are as follows: high cost; the guiding drugs at the upper limb part are: ramulus Cinnamomi; the guiding drug for the chest and the waist is as follows: eucommia ulmoides; the leg guiding drugs are as follows: achyranthis radix; the foot guiding drugs are as follows: achyranthis radix and fructus Chaenomelis.
The traditional Chinese medicine composition has the greatest characteristics of low cost (all the used traditional Chinese medicinal materials are common medicinal materials), greatly lightening the economic burden of patients, and being proved by a large number of actual patients to have quick response, and patients with slight bone fracture can be cured within one to two treatment courses (7-14 days); patients with fracture and comminuted fracture can be cured after three to four courses of treatment (slight difference according to age), and the time for the patients to lie in bed is greatly reduced.
Specific example 2:
the patient is the fracture of the upper limb part, so the guiding drug adopted is cassia twig;
therefore, in the embodiment, the invention provides a traditional Chinese medicine preparation for promoting fracture healing, which is prepared from the following raw materials in parts by weight: 26 parts of dragon's blood, 28 parts of ground beeltle, 17 parts of pseudo-ginseng, 15 parts of frankincense, 16 parts of powder drug, 25 parts of Chinese angelica, 14 parts of ligusticum wallichii, 12 parts of safflower, 17 parts of dipsacus root, 33 parts of native copper, 15 parts of raw rapeseed, 55 parts of muskmelon seed, 58 parts of cucumber seed, 14 parts of catechu and 15 parts of cassia twig. The specific procedure is similar to that of example 1 and will not be discussed.
Specific example 3:
the patient is the fracture of the chest and the waist, so the guiding drug is eucommia bark;
therefore, in the embodiment, the invention provides a traditional Chinese medicine preparation for promoting fracture healing, which is prepared from the following raw materials in parts by weight: 26 parts of dragon's blood, 28 parts of ground beeltle, 17 parts of pseudo-ginseng, 15 parts of frankincense, 16 parts of powder, 25 parts of Chinese angelica, 14 parts of ligusticum wallichii, 12 parts of safflower, 17 parts of dipsacus root, 33 parts of native copper, 15 parts of raw rapeseed, 55 parts of balsam pear seed, 58 parts of cucumber seed, 14 parts of catechu and 15 parts of eucommia bark. The specific preparation process is similar to that of example 1 and will not be discussed.
Specific example 4:
the patient is leg fracture, so the guiding drug adopted is achyranthes bidentata;
therefore, in the embodiment, the invention provides a traditional Chinese medicine preparation for promoting fracture healing, which is prepared from the following raw materials in parts by weight: 26 parts of dragon's blood, 28 parts of ground beeltle, 17 parts of pseudo-ginseng, 15 parts of frankincense, 16 parts of powder, 25 parts of Chinese angelica, 14 parts of ligusticum wallichii, 12 parts of safflower, 17 parts of dipsacus root, 33 parts of native copper, 15 parts of raw rapeseed, 55 parts of muskmelon seed, 58 parts of cucumber seed, 14 parts of catechu and 15 parts of achyranthes bidentata. The specific preparation process is similar to that of example 1 and will not be discussed.
Specific example 5:
the patient is the foot fracture, so the guiding drugs adopted are achyranthes and pawpaw;
therefore, in the embodiment, the invention provides a traditional Chinese medicine preparation for promoting fracture healing, which is prepared from the following raw materials in parts by weight: 26 parts of dragon's blood, 28 parts of ground beeltle, 17 parts of pseudo-ginseng, 15 parts of frankincense, 16 parts of powder, 25 parts of Chinese angelica, 14 parts of ligusticum wallichii, 12 parts of safflower, 17 parts of dipsacus root, 33 parts of native copper, 15 parts of raw rapeseed, 55 parts of muskmelon seed, 58 parts of cucumber seed, 14 parts of catechu, 8 parts of achyranthes bidentata and 8 parts of pawpaw. The specific preparation process is similar to that of example 1 and will not be discussed.
First, acute oral toxicity test
The acute oral toxicity of the traditional Chinese medicine preparation for promoting fracture healing prepared in examples 1-5 is detected by taking healthy Kunming mice with similar body weights and adopting a conventional acute toxicity test method, and the detection results are shown in table 1 as follows:
| group of | Acute oral toxicity LD50(mg/kgb. wt) |
| Example 1 | >12000 (non-toxic) |
| Example 2 | >12000 (non-toxic) |
| Example 3 | >12000 (non-toxic) |
| Example 4 | >12000 (non-toxic) |
| Example 5 | >12000 (non-toxic) |
From the results, the safety toxicological evaluation of the traditional Chinese medicine composition prepared by the invention is non-toxic, and has no toxic or side effect.
Second, clinical trial
The tests of the Chinese medicinal preparation for promoting fracture healing prepared in examples 1-5 were carried out, specifically, 150 cases of patients with bone fracture were collected, aged 18 to 50 years and divided into A, B, C, D, E groups of 30 patients each,
wherein group A is head fracture; group B refers to fracture of upper limb; group C is fracture of chest and waist; group D is leg fracture; and the group E shows foot fracture.
Wherein, the group A takes the Chinese medicinal preparation prepared in the example 1, the group B takes the Chinese medicinal preparation prepared in the comparative example 2, the group C takes the Chinese medicinal preparation prepared in the comparative example 3, the group D takes the Chinese medicinal preparation prepared in the comparative example 4, and the group E takes the Chinese medicinal preparation prepared in the comparative example 5.
The medicine is taken half an hour before breakfast and half an hour after supper, twice a day and 7 days as a treatment course. The medicine is taken for 1-4 courses. The treatment time is calculated according to the severity of the illness state of the patient.
The plaster is taken from the moment that the effect of X-ray is satisfactory after plaster fixation of a bone fracture patient, the effect is checked after 4 treatment courses, and the effect is specifically divided into effective effect, obvious effect and ineffective effect, wherein the effective effect is that the imaging shows that the bone dementia is basically formed, the fracture alignment is good, the fracture can move slightly, and the swelling and pain of the affected limb disappear; the obvious effect is that the imaging shows that the continuity of the bony vascular is formed, the alignment is good, the patient can move slightly, and the swelling and pain of the affected limb basically disappear; the ineffectiveness means no change in signs and symptoms, and the detection results are shown in table 1.
| Group of | Effective/example | Significant effects/examples | Invalid/example | Total effective rate/%) |
| Group A | 18 | 8 | 4 | 86.7 |
| Group B | 19 | 8 | 3 | 90 |
| Group C | 21 | 3 | 6 | 80 |
| Group D | 22 | 7 | 1 | 96.7 |
| Group E | 23 | 5 | 2 | 93.3 |
The data comparison in the above table shows that different guiding drugs are used as auxiliary drugs to enhance the drug effect according to the fracture part, so that the formation effect of the bone dementia can be effectively improved.
Typical cases are as follows:
case one: liu is a male, the age of 53 is 53, the left leg and the lower leg are more fractured due to traffic accidents, after reduction by doctors, the pain is relieved after the medicine is taken for three days, the swelling of the fractured part is gradually reduced, and after 7 days, the pain is eliminated and no obvious swelling exists. After two treatment courses, the fractured shank can be slightly moved. After three treatment courses, the X-ray film shows that the bone is basically formed and the fracture alignment is good.
Case two: some, male, 25 years old, playing basketball resulted in a right arm fracture. After taking the medicine for three days, the pain feeling disappears. After 7 days, the fractured arms were allowed to move slightly. After 10 days, reexamination shows that the bone is basically formed and the fracture is aligned well.
Case three: zhao, a woman in age 30, and a slippery and falling down on the road in winter, which results in a fracture of the wrist. After the medicine is taken for two days after reduction and fixation, the pain is obviously relieved, and after five days, the swelling is eliminated. After two treatment courses are finished, the formation of the vascular dementia is basically displayed on an X-ray film through reexamination, and the fracture alignment is good.
Furthermore, the composition is not limited to traditional Chinese medicine powder, and can be combined with pharmaceutically acceptable auxiliary materials to be processed according to a conventional method to prepare coated tablets, capsules or oral liquid.
Further comprises step 5, drying and sterilizing the mixed medicinal powder at high temperature, and preparing into coated tablets or capsules or oral liquid. Wherein the preparation method of the coated tablet in step 5 is as follows: pressing the mixed medicinal powder into tablet, coating with Opadry AMB coating solution with concentration of 5% at flow rate of 0.25-0.28kg/min, core temperature of 50-55 deg.C, and rotation speed of 7-9 r/min.
The above embodiments are merely illustrative of the preferred embodiments of the present invention, and not restrictive, and various changes and modifications to the technical solutions of the present invention may be made by those skilled in the art without departing from the spirit of the present invention, and the technical solutions of the present invention are intended to fall within the scope of the present invention defined by the appended claims.
Claims (8)
1. A traditional Chinese medicine preparation for promoting fracture healing is characterized in that: the composite material is prepared from the following raw materials in parts by weight: 20-30 parts of dragon's blood, 25-30 parts of ground beetle, 15-20 parts of pseudo-ginseng, 12-17 parts of frankincense, 12-14 parts of powder medicine, 20-30 parts of angelica, 10-16 parts of ligusticum wallichii, 10-14 parts of safflower, 15-20 parts of dipsacus root, 30-35 parts of native copper, 12-17 parts of raw rapeseed, 50-60 parts of muskmelon seed, 55-60 parts of cucumber seed, 12-16 parts of catechu and 15-20 parts of guiding drug, wherein the guiding drug is high-yield/cassia twig/eucommia bark/achyranthes bidentatae.
2. The traditional Chinese medicine preparation for promoting fracture healing according to claim 1, which is characterized in that: the composite material is prepared from the following raw materials in parts by mass: 26 parts of dragon's blood, 28 parts of ground beeltle, 17 parts of pseudo-ginseng, 15 parts of frankincense, 16 parts of powder, 25 parts of Chinese angelica, 14 parts of ligusticum wallichii, 12 parts of safflower, 17 parts of dipsacus root, 33 parts of native copper, 15 parts of raw rapeseed, 55 parts of muskmelon seed, 58 parts of cucumber seed, 14 parts of catechu and 15 parts of guiding drug, wherein the guiding drug is Gaoyan/cassia twig/eucommia bark/achyranthes bidentata.
3. The preparation method of the traditional Chinese medicine preparation for promoting fracture healing according to claim 1, which is characterized by comprising the following steps: step 1: weighing dragon's blood, ground beetle, pseudo-ginseng, frankincense, powder medicine, Chinese angelica, ligusticum wallichii, safflower, dipsacus root, native copper, raw rapeseed, muskmelon seed, cucumber seed, catechu and guiding medicine according to the weight part ratio, removing moldy Chinese medicinal materials, cleaning the Chinese medicinal materials, drying and reserving for later use;
step 2: frying the raw rapeseed, the cucumber seed and the cucumber seed treated in the step (1) to be cooked and cooling to room temperature for later use;
and step 3: respectively grinding the cleaned and dried dragon's blood, ground beeltle, pseudo-ginseng, frankincense, powder, Chinese angelica, ligusticum wallichii, safflower, dipsacus root, native copper, catechu and guiding drug in the step 1, as well as the fried and cooled raw rapeseed, cucumber seed and cucumber seed in the step 2 into powder, sieving, and respectively sealing and packaging in independent vessels;
and 4, step 4: and (4) taking the traditional Chinese medicine raw material powder out of each independent vessel in the step (3) to be mixed, and uniformly stirring to prepare mixed medicinal material powder.
4. The method for preparing a Chinese medicinal preparation for promoting fracture healing according to claim 3, wherein in step 1, all the Chinese medicinal herbs are cleaned, placed in a dryer, vacuum-dried at 60 ℃ for 12h, and then cooled to room temperature.
5. The method for preparing a Chinese medicinal preparation for promoting fracture healing according to claim 3, wherein in step 3, each Chinese medicinal material is ground by a grinder, and each Chinese medicinal material is sieved by a 120-mesh filter screen.
6. The preparation method of the traditional Chinese medicine preparation for promoting fracture healing as claimed in claim 3, wherein in the step 4, mechanical stirring is carried out for 10min at a stirring speed of 300r/min, and then ultrasonic treatment is carried out by adopting an ultrasonic wall breaking technology to obtain mixed medicinal material powder.
7. The method for preparing a Chinese medicinal preparation for promoting fracture healing as claimed in claim 3, further comprising step 5, drying and sterilizing the mixed medicinal powder at high temperature, and making into coated tablet, capsule or oral liquid.
8. The method for preparing a Chinese medicinal preparation for promoting fracture healing according to claim 7, wherein the coated tablet in step 5 is prepared by the following steps: pressing the mixed medicinal powder into tablet, coating with Opadry AMB coating solution with concentration of 5% at flow rate of 0.25-0.28kg/min, core temperature of 50-55 deg.C, and rotation speed of 7-9 r/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210236713.2A CN114470083A (en) | 2022-03-11 | 2022-03-11 | Traditional Chinese medicine preparation for promoting fracture healing and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210236713.2A CN114470083A (en) | 2022-03-11 | 2022-03-11 | Traditional Chinese medicine preparation for promoting fracture healing and preparation method thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114470083A true CN114470083A (en) | 2022-05-13 |
Family
ID=81486072
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210236713.2A Pending CN114470083A (en) | 2022-03-11 | 2022-03-11 | Traditional Chinese medicine preparation for promoting fracture healing and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114470083A (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1322565A (en) * | 2001-04-18 | 2001-11-21 | 魏吉村 | Fracture setting pellet |
| CN101019975A (en) * | 2007-03-14 | 2007-08-22 | 吴方忠 | Fracture treating Chinese medicine composition and its prepn |
| CN102614245A (en) * | 2011-08-25 | 2012-08-01 | 张万坤 | Externally applied Chinese medicinal composition for bonesetting |
| CN102940751A (en) * | 2012-11-06 | 2013-02-27 | 王小宇 | Dieda (Chinese Name) blood-activating dropping pill and preparation method thereof |
| CN107929469A (en) * | 2017-12-29 | 2018-04-20 | 张华丰 | A kind of Chinese medicine for treating fracture and preparation method thereof |
| CN109731059A (en) * | 2019-03-08 | 2019-05-10 | 姚俊卫 | A kind of Chinese medicine composition and preparation method thereof for treating fracture |
-
2022
- 2022-03-11 CN CN202210236713.2A patent/CN114470083A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1322565A (en) * | 2001-04-18 | 2001-11-21 | 魏吉村 | Fracture setting pellet |
| CN101019975A (en) * | 2007-03-14 | 2007-08-22 | 吴方忠 | Fracture treating Chinese medicine composition and its prepn |
| CN102614245A (en) * | 2011-08-25 | 2012-08-01 | 张万坤 | Externally applied Chinese medicinal composition for bonesetting |
| CN102940751A (en) * | 2012-11-06 | 2013-02-27 | 王小宇 | Dieda (Chinese Name) blood-activating dropping pill and preparation method thereof |
| CN107929469A (en) * | 2017-12-29 | 2018-04-20 | 张华丰 | A kind of Chinese medicine for treating fracture and preparation method thereof |
| CN109731059A (en) * | 2019-03-08 | 2019-05-10 | 姚俊卫 | A kind of Chinese medicine composition and preparation method thereof for treating fracture |
Non-Patent Citations (1)
| Title |
|---|
| 刘向前等: "《骨伤科常用中药的配伍运用》", 31 January 2007, 人民军医出版社 * |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105982976B (en) | Treat bone penetrating fluid of bone and joint diseases and preparation method thereof | |
| CN114470083A (en) | Traditional Chinese medicine preparation for promoting fracture healing and preparation method thereof | |
| CN109432309B (en) | Traditional Chinese medicine composition, external medicinal liquor, and preparation method and application thereof | |
| CN101474331A (en) | Chinese medicine plaster for dispersing swelling | |
| CN104258113B (en) | A kind of Chinese medicine composition for the treatment of cerebral hemorrhage | |
| CN110538259A (en) | Traditional Chinese medicine preparation for promoting fracture healing and preparation method thereof | |
| CN104435136B (en) | A kind of pharmaceutical composition promoting union of fracture and preparation method thereof | |
| CN104547489A (en) | Use of traditional Chinese medicine composition in preparation of medicine for treating comminuted fracture | |
| CN103536643A (en) | Chinese medicine herb preparation for enhancing bone mineral density and preparation process thereof | |
| CN107308233A (en) | Pharmaceutical composition for treating Bone and joint trauma and soft-tissue trauma | |
| CN1250245C (en) | Capsule for treating osteonecrosis and bone fracture | |
| CN103735676B (en) | A kind of compound Chinese medicinal preparation for the treatment of traumatic injury and its preparation method and application | |
| CN102091204B (en) | Traditional Chinese medicinal composition for treating traumatic injury and deep phlebitis, and preparation method and use thereof | |
| CN114377063B (en) | Traditional Chinese medicine composition for treating delayed fracture healing | |
| CN102178758A (en) | Medicament for treating peripheral nerve of diabetes | |
| CN106692873A (en) | Formula and preparation method of traditional Chinese medicine for treatimg hyperlipemia | |
| CN111329941A (en) | Traditional Chinese medicine composition for treating fracture injury and preparation and application thereof | |
| CN107468917B (en) | Traditional Chinese medicine composition for treating coronary heart disease by reducing phlegm and detoxifying and application thereof | |
| CN107281444B (en) | Analgesic pharmaceutical composition and preparation method and application thereof | |
| CN112569319A (en) | Traditional Chinese medicine composition formula and application thereof, traditional Chinese medicine preparation method and traditional Chinese medicine preparation | |
| CN104984059A (en) | External preparation for treating osteomyelitis and preparing method | |
| CN104800706A (en) | Medicine for treating fracture of femoral shaft and preparation method thereof | |
| CN105168945A (en) | External ointment for promoting fracture healing and preparation method of external ointment | |
| CN104435883A (en) | Traditional Chinese medicine preparation for treating calcaneodynia | |
| CN107496752A (en) | A kind of Chinese medicine composition for treating rheumatism bone disease and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| RJ01 | Rejection of invention patent application after publication |
Application publication date: 20220513 |
|
| RJ01 | Rejection of invention patent application after publication |