CN114469188A - Flexible body surface sweat collecting device - Google Patents
Flexible body surface sweat collecting device Download PDFInfo
- Publication number
- CN114469188A CN114469188A CN202210096857.2A CN202210096857A CN114469188A CN 114469188 A CN114469188 A CN 114469188A CN 202210096857 A CN202210096857 A CN 202210096857A CN 114469188 A CN114469188 A CN 114469188A
- Authority
- CN
- China
- Prior art keywords
- sweat
- collection
- layer
- collecting
- skin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004243 sweat Anatomy 0.000 title claims abstract description 79
- 239000010410 layer Substances 0.000 claims abstract description 44
- 239000011241 protective layer Substances 0.000 claims abstract description 11
- 210000003491 skin Anatomy 0.000 claims description 10
- 239000000463 material Substances 0.000 claims description 5
- 210000000438 stratum basale Anatomy 0.000 claims description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 229920000742 Cotton Polymers 0.000 claims description 2
- 229920000728 polyester Polymers 0.000 claims description 2
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 239000012141 concentrate Substances 0.000 claims 1
- 239000004744 fabric Substances 0.000 claims 1
- 239000000758 substrate Substances 0.000 abstract description 8
- 230000010354 integration Effects 0.000 abstract 1
- 230000002045 lasting effect Effects 0.000 abstract 1
- 238000011161 development Methods 0.000 description 5
- 238000010147 laser engraving Methods 0.000 description 4
- 229910021592 Copper(II) chloride Inorganic materials 0.000 description 2
- 238000013461 design Methods 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000014509 gene expression Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 201000003883 Cystic fibrosis Diseases 0.000 description 1
- 239000004677 Nylon Substances 0.000 description 1
- 239000004642 Polyimide Substances 0.000 description 1
- 239000002390 adhesive tape Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 238000003255 drug test Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003792 electrolyte Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000005556 hormone Substances 0.000 description 1
- 229940088597 hormone Drugs 0.000 description 1
- 239000002207 metabolite Substances 0.000 description 1
- 238000012544 monitoring process Methods 0.000 description 1
- 229920001778 nylon Polymers 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920001721 polyimide Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 229920006395 saturated elastomer Polymers 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000004088 simulation Methods 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
- A61B10/0045—Devices for taking samples of body liquids
- A61B10/0064—Devices for taking samples of body liquids for taking sweat or sebum samples
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/14507—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood
- A61B5/14517—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue specially adapted for measuring characteristics of body fluids other than blood for sweat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
- A61B5/1468—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means
- A61B5/1477—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using chemical or electrochemical methods, e.g. by polarographic means non-invasive
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Surgery (AREA)
- Pathology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Optics & Photonics (AREA)
- Biophysics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Measuring And Recording Apparatus For Diagnosis (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention relates to a flexible body surface sweat collecting device which comprises a substrate layer, a collecting layer and a protective layer which are sequentially stacked from bottom to top. The basal layer is provided with a collecting hole for collecting sweat from the surface of the skin; the collecting layer consists of a collecting point, a flow guide channel and a sweat concentration area, wherein the collecting point is arranged above the corresponding collecting hole of the basal layer; the protective layer is provided with an output port, and the output port is arranged above the sweat concentration area during setting. When the sweat collecting and taking device is used, the sweat collecting and taking device is attached to the surface of skin, and sweat is collected, conveyed, enriched and flowed out through the collecting hole, the collecting point, the flow guide channel, the sweat concentrating area and the output port. The device can carry out high-efficient, quick and lasting collection to skin sweat, and simple structure, low cost, easy integration have fine application prospect in wearable biosensing device field.
Description
One, the technical field
The invention relates to a patch type skin sweat collecting device.
Second, background Art
Sweat is rich in biomolecules such as proteins, hormones, electrolytes and metabolites, and the information of the existence state of the biomolecules is closely related to human health. Meanwhile, the sweat sensor has become a development hotspot in the field of human body biochemical sensors because sweat has the advantages of continuous secretion, non-invasive collection, no biological pollution and the like. With the rapid development of the flexible smart wearable sensing field, various wearable sweat biosensors have been proposed and used for monitoring of human physiological states and diagnosis of diseases, such as cystic fibrosis disease screening, drug testing of athletes, and the like.
However, the development of wearable sweat biosensors is still in the laboratory model stage, and no mature and stable wearable sweat biosensor is available on the market. One of the difficulties in commercialization development is the lack of an effective sweat collection device. In the existing wearable sweat biosensor design, a biosensing interface is generally directly attached to the skin surface for sweat detection, which requires a large amount of local sweat (to cover the whole sensing interface), so an iontophoresis sweat device is generally required to be configured. However, iontophoresis sweating is likely to cause discomfort to human body, and direct attachment of the biosensing interface to the skin is likely to cause interface contamination, unstable test, and the like, so that development of a skin-friendly efficient sweat collection device is urgently needed.
The invention provides a flexible body surface sweat collecting device which effectively improves the sweat collecting efficiency by designing a multi-point concentration type sweat collecting mode of 'collecting point → flow guide channel → sweat concentration area', has simple preparation process and low cost, and has great application prospect in wearable sweat biosensors.
Third, the invention
The invention aims to provide a flexible body surface sweat collecting device, which can realize the efficient collection of sweat on the surface of human skin.
The invention is realized by the following technical scheme:
a flexible body surface sweat collecting device comprises a substrate layer, a collecting layer and a protective layer (figure 1) which are sequentially stacked from bottom to top: the basal layer is provided with a collecting hole for collecting sweat from the surface of the skin; the collecting layer consists of a collecting point, a flow guide channel and a sweat concentration area, and the collecting point is correspondingly arranged above the collecting hole of the substrate layer during setting; the protective layer is provided with an output port which is arranged above the sweat concentration area of the collection layer; during the use device passes through the stratum basale and pastes in the skin surface, and sweat is gathered, is carried, enrichment and outflow through collection hole, collection point, water conservancy diversion passageway, sweat concentration district and delivery outlet realization.
The substrate layer is made of a flexible material which is skin-friendly and has two sticky sides, one side is used for being attached to the skin, and the other side is used for fixing the collecting layer.
The substrate layer is provided with a plurality of collecting holes, and the number, distribution, shape and size of the collecting holes correspond to those of the collecting points on the collecting layer.
The collecting layer is made of super-hydrophilic flexible material, and can be one of filter paper, chromatographic paper, fiber, polyester cotton and the like.
The collecting points on the collecting layer are uniformly distributed on the flow guide channel and are connected with the sweat concentration area through the flow guide channel.
The collecting layer is provided with a plurality of flow guide channels which are distributed on the periphery of the sweat concentration area in a criss-cross mode.
Compared with the prior art, the invention has the following beneficial effects:
(1) the sweat collecting and fetching device adopts a multi-point collecting type sweat collecting and fetching strategy of 'collecting point → flow guide channel → sweat concentration area', and can efficiently collect and fetch skin sweat.
(2) The sweat collecting device can be prepared by commercialized filter paper, nylon, medical double-sided adhesive tape and other materials, and has the advantages of ingenious design, simple process and low cost.
(3) The sweat collecting and taking device can continuously collect sweat on each part of a body, can be flexibly combined with the electrochemical sensing chip, and develops the wearable sweat biosensor.
Description of the drawings
FIG. 1 is a schematic view of a flexible body surface sweat collection device according to the present invention;
FIG. 2 is a drawing showing an acquisition layer prepared by laser engraving.
FIG. 3 shows the solution collection effect of the flexible body surface sweat collection device at different time periods.
Fig. 4 is a wearable sweat biosensor device integrated based on a flexible body surface sweat collection device.
Fifth, detailed description of the invention
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are exemplary of the invention, are intended to be illustrative of the invention, and are not intended to limit the invention.
The flexible body surface sweat collecting device consists of a substrate layer, a collecting layer and a protective layer (figure 1), wherein the substrate layer and the protective layer are prepared from commercial medical polyimide double-sided films, and the collecting layer is prepared from filter paper.
The collecting layer utilizes CO2-laser engraving preparation (fig. 2), comprising: a rectangular configuration of sweat concentration zones (9 and 18mm in length and width, respectively); a plurality of flow guide channels which are criss-cross and surround the periphery of the sweat concentration area, and the width of each flow guide channel is 0.6 mm; 96 collection points which are uniformly distributed on the flow guide channel comprise 72 semicircular collection points and 24 circular collection points, the diameter of each collection point is 3mm, and the collection points are connected with a sweat concentration area through the flow guide channel.
The basal layer is provided with a collecting hole which utilizes CO2And preparing by a laser engraving method, wherein the number, distribution, shape and size of the collecting holes correspond to the collecting points on the collecting layer one by one.
The protective layer is provided with an output port which utilizes CO2Laser engraving, the position, shape and size of the outlet opening corresponding to the sweat concentration area on the collection layer.
The flexible body surface sweat collection and collection device is formed by stacking a basal layer, a collection and collection layer and a protective layer from bottom to top in sequence, ensures that all collection points are arranged on a collection hole of the basal layer in a one-to-one correspondence manner when the collection and collection layer is arranged, and ensures that an output port is arranged in a sweat concentration area when the protective layer is arranged.
The flexible body surface sweat collection device prepared by the embodiment carries out sweat collection simulation experiment on 96 point samples: the positions of 72 points correspond to 72 semicircular collection points on the collection layer, each point having 1 μ L of CuCl2A solution; another 24 spot locations correspond to 24 circular collection spots on the collection layer, each spot having 2 μ L of CuCl2And (3) solution. The results show that trapping 25s allowed the sweat concentration region to be saturated with solution (fig. 3).
The flexible body surface sweat collection device prepared by the embodiment can be combined with a flexible electrochemical sensing chip, integrates a wearable sweat biosensor device (figure 4), and continuously senses and detects human sweat. The assembly of the flexible body surface sweat collecting device and the flexible electrochemical sensing chip is completed by arranging the flexible electrochemical sensing chip between the substrate layer and the collecting layer, and the electrochemical sensing interface is ensured to be arranged below a sweat concentration area of the collecting layer and to be in close contact with the sweat concentration area.
The apparatus embodiments described above are illustrative only, the terms and expressions employed are used as terms of description and not of limitation, and there is no intention in the use of such terms and expressions of excluding any equivalents of the features shown and described or portions thereof.
Claims (5)
1. The utility model provides a device is got to flexible body surface sweat collection, its characterized in that it includes from down and the stratum basale, the collection of range upon range of setting in proper order and gets layer and protective layer, there is the collection hole on the stratum basale for collect the sweat from the skin surface, the layer is got by the collection and some, water conservancy diversion passageway and sweat are concentrated the district and are constituted, and the collection point is arranged in the collection hole top that the stratum basale corresponds in the collection point during setting, there is the delivery outlet on the protective layer, and the delivery outlet is arranged in the collection and is got the sweat of layer and concentrate the district top during setting, and the device is pasted in the skin surface through the stratum basale during use, and the sweat is gathered, is carried, enrichment and is flowed through collection hole, collection point, water conservancy diversion passageway, sweat concentration district, delivery outlet realization.
2. A sweat collection device according to claim 1, wherein said base layer is made of a skin-friendly flexible material having a plurality of collection wells therein, the number, distribution, shape and size of the collection wells corresponding to the collection points on the collection layer.
3. A sweat collection device according to claim 1, wherein said collection layer is made of a super hydrophilic flexible material, which may be one of filter paper, chromatography paper, fabric, polyester cotton, and the like.
4. A sweat collection device according to claim 1, wherein the collection points on said collection layer are evenly distributed across the flow channel and connected to a sweat collection area by the flow channel.
5. A sweat collection device according to claim 1, wherein said collection layer has a plurality of flow channels extending transversely across the periphery of the sweat collection region.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210096857.2A CN114469188A (en) | 2022-01-26 | 2022-01-26 | Flexible body surface sweat collecting device |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210096857.2A CN114469188A (en) | 2022-01-26 | 2022-01-26 | Flexible body surface sweat collecting device |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114469188A true CN114469188A (en) | 2022-05-13 |
Family
ID=81476075
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210096857.2A Pending CN114469188A (en) | 2022-01-26 | 2022-01-26 | Flexible body surface sweat collecting device |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114469188A (en) |
-
2022
- 2022-01-26 CN CN202210096857.2A patent/CN114469188A/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2432452C (en) | Analyte measurement | |
| CN112494037B (en) | Wearable cloth-based electrochemical sweat sensing device and method | |
| CN104768457A (en) | Diagnostic device and method for sensing hydration state of mammalian subject | |
| WO2018067412A1 (en) | Method and systems for a sensor patch with embedded microfluidics for monitoring of fluid biomarkers | |
| CN108553102A (en) | A kind of flexible extensible multichannel convex surface myoelectricity pole and preparation method thereof | |
| CN209644909U (en) | Tissue fluid extraction element | |
| CN111007124B (en) | Sensor for sweat detection and preparation method thereof | |
| TW202000135A (en) | Flexible ultra low profile transcutaneous continuous monitoring sensor | |
| CN111568474A (en) | Paper-pasted sweat sensor with sweat collection and collection structure | |
| WO2018167508A1 (en) | A monitoring device | |
| CN114469188A (en) | Flexible body surface sweat collecting device | |
| CN211955226U (en) | Mouth-operated oral cavity detection mechanism and corresponding intelligent oral cavity detector | |
| CN113520381A (en) | Differential admittance type microfluidic channel for measuring sweating rate | |
| CN208693290U (en) | A kind of flexible extensible multichannel convex surface myoelectricity pole | |
| Asadi et al. | A review on wearable sensors for sodium detection in human sweat | |
| CN115919304A (en) | SMD wearable metabolite detection device | |
| CN113598760B (en) | Biological monitoring device | |
| CN113680403B (en) | Microfluidic chip for sweat continuous sampling and constant-speed shunt and working method thereof | |
| CN114113266A (en) | Sensing device for analyzing sweat marker | |
| CN200975990Y (en) | Liquid detection test piece | |
| Yulianti et al. | Sweat sensing in wearable sensor: A review of the future non-invasive technology for real-time health monitoring system | |
| CN219126451U (en) | Sweat collecting bag for sole of animal | |
| CN118319299A (en) | Flexible wearable double-channel sweat sensing device and preparation method thereof | |
| CN114557694B (en) | Noninvasive subcutaneous tissue fluid extraction-detection device and extraction-detection method | |
| CN219089303U (en) | Wearable flexible patch for detecting sweat glucose and PH value |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication |