CN211955226U

CN211955226U - Mouth-operated oral cavity detection mechanism and corresponding intelligent oral cavity detector

Info

Publication number: CN211955226U
Application number: CN202020434260.0U
Authority: CN
Inventors: 张佩刚
Original assignee: Shanghai Relax Material Technology Co ltd
Current assignee: Shanghai Relax Material Technology Co ltd
Priority date: 2020-03-30
Filing date: 2020-03-30
Publication date: 2020-11-17
Anticipated expiration: 2030-03-30

Abstract

The utility model relates to a mouth-operated oral cavity detection mechanism and a corresponding intelligent oral cavity detector, wherein the mouth-operated oral cavity detection mechanism comprises a hollow blowpipe and a detection chip, and a first opening with the size matched with the size of the detection chip is arranged on the pipe wall of the blowpipe; the detection chip comprises a sample inlet hole, a sample inlet channel, a detection pool and a reaction module which are arranged in sequence; the detection chip is provided with a first opening, one end of the sampling hole is inserted into the blowpipe, when the intelligent oral cavity detector comprising the mouth-operated oral cavity detection mechanism is used for testing, saliva can be blown to the detection pool of the chip by adopting the power of a human body, namely blowing force, so that the detector can conveniently detect the saliva and/or breath, and the detection can be conveniently realized by adopting the detector of the mechanism. Adopt the utility model discloses a formula oral cavity detection mechanism is moved to mouth and corresponding intelligent oral cavity detector possesses with low costs, convenient to use, characteristics that the suitability is good.

Description

Mouth-operated oral cavity detection mechanism and corresponding intelligent oral cavity detector

Technical Field

The utility model relates to a medical instrument field especially relates to medical detector and micro-fluidic chip and makes technical field, specifically indicates a formula oral cavity detection mechanism and corresponding intelligent oral cavity detector are moved to mouth.

Background

In exosomes in a human body, saliva is most easily obtained, and through research, many indexes in human body breath and saliva are positively correlated with body health, and can reflect cancers, infections, systemic diseases and the like generated by the body.

However, the prior art devices for sampling saliva and breath have some drawbacks, and the specific problems are as follows:

the detection is carried out by adopting the detection equipment in the prior art, the collection is inconvenient, the process is troublesome, and the detection result is lack of comparison samples; the collection device of the breath sample has the defects of large volume, difficult sample preservation, complex subsequent sample treatment process and the like; the exosome detection device rarely has the function that the detection device can synchronously realize the integration of collection, detection and uploading of samples; and the preparation steps are complicated, the technology is complex, the price is high, the popularization is difficult, and the industrialization of the research results is difficult.

The micro-fluidic chip in the prior art generally includes two types, an active chip and a passive chip, wherein:

the active chip generally must use power such as a micro motor or a micro pump to provide a driving source for the liquid flow; the active chip (driven by the instrument) controls the position of liquid reaction by precisely controlling a reaction cavity in the chip and combining a valve device in the instrument, monitors the flowing condition of liquid in the chip in real time, and quantitatively controls the volume of a reaction sample, so that the sample quantitatively participates in immune reaction, and the accurate and controllable flow is really achieved;

the passive chip (self-driven by capillary) does not depend on external force, so that the microfluidic chip is not microfluidic in a strict sense and has no control on liquid flow.

In summary, the active chip needs to be used together with an external instrument, the equipment cost is high, and the passive chip has certain uncontrollable property.

The paper microfluidic chip of the microfluidic chip in the prior art has the problems of slow sample liquid migration speed and complex processing technology, and is mainly made of ceramic, silicon chip, glass, PET, acrylic and other materials; the micro-fluidic chip has a complex structure (the reaction cannot be accurately regulated and controlled); the processing process is completed by adopting ultrasonic waves and laser, so that multiple manual steps are required, and the equipment requirement is high; the packaging is carried out by adopting ultrasonic waves and EVA (ethylene vinyl acetate) glue, and the manual assembly steps are multiple; moreover, due to the complicated processing process, the precision difference between batches is large and the sensitivity is low; because it generally needs to be reused, it needs to be cleaned, the cleaning step and the liquid conduction cause great pollution; a plurality of liquid chambers and solid phase carriers, the overall design is complex; insufficient reaction, limited repeatability and poor accuracy; in the use, need provide power for it through equipment such as micromotor, micropump, instrument, generally need the laboratory customization, output is very low, so the cost is higher, and the price generally lies in: the micro-fluidic chip is not less than 200 yuan/piece and not more than 1200 yuan/piece.

The problems not only influence the application of innovative products such as microfluidic chips, but also influence the popularization of related products. Therefore, there is a need to develop a new microfluidic chip for biological sample collection.

SUMMERY OF THE UTILITY MODEL

The utility model aims at overcoming at least one above-mentioned prior art's shortcoming, providing a mouth of good performance, with low costs, easily operation moves formula oral cavity detection mechanism and corresponding intelligent oral cavity detector.

In order to realize above-mentioned purpose or other purposes, the utility model discloses a mouth moves formula oral cavity detection mechanism and corresponding intelligent oral cavity detector as follows:

the mouth-operated oral cavity detection mechanism is mainly characterized in that the mechanism comprises a hollow blowpipe and a detection chip;

a first opening with the size matched with that of the detection chip is arranged on the pipe wall of the blow pipe, and a through hole is formed in the blow pipe;

the detection chip comprises a sample inlet hole, a sample inlet channel, a detection pool and a reaction module which are arranged in sequence;

one end of the detection chip, which is provided with the sample injection hole, is inserted into the first opening of the blow pipe, and the sample injection hole faces the through hole.

Preferably, the detection chip is perpendicular to the pipe wall of the blow pipe, and the horizontal height of the inner wall surface of the blow pipe at the position adjacent to the first opening is the lowest.

Preferably, the outer surface of the detection chip is provided with a limiting structure for limiting the length of the detection chip inserted into the first opening of the blow pipe.

Preferably, the detection chip is provided with an exhaust hole for exhausting gas in the detection cell.

Preferably, when the detection chip is used for detecting saliva, the detection chip comprises a cover plate, a filter membrane, a substrate and a bottom plate;

the substrate is provided with a channel with a preset length to form the sample feeding channel, two ends of the channel are respectively provided with two openings, and the two openings respectively form the sample feeding hole and the detection pool;

the bottom plate is arranged on one surface of the substrate, and the reaction module is arranged between the bottom plate and the substrate and is contacted with the detection pool;

the filter membrane cover in the another side of base plate, the apron locate the filter membrane in with the one side of base plate contact, just the apron not cover the inlet hole.

Preferably, the cover plate, the filter membrane, the base plate and the bottom plate are bonded through hot melt adhesive.

Preferably, when the detection chip is a dual-function chip for simultaneously detecting saliva and breath, the reaction module comprises a liquid reaction module and a gas reaction module;

the detection chip comprises an upper cover plate, an upper substrate, a middle partition plate, a lower substrate and a lower cover plate;

the upper cover plate is provided with a channel with a preset length to form the sample feeding channel, one end of the channel is provided with a first opening to form the sample feeding hole, the upper cover plate is arranged on one surface of the upper base plate, and the upper cover plate does not cover the sample feeding hole;

the middle clapboard is arranged on one surface of the upper substrate which is not contacted with the upper cover plate, and the gas reaction module is arranged between the middle clapboard and the upper substrate and is connected with the sample feeding channel;

the lower substrate is provided with a second hole to form a detection pool, and one surface of the lower substrate, which is not contacted with the upper substrate, is attached to the middle partition plate;

the liquid reaction module is attached to one surface of the lower substrate, which is not contacted with the middle partition plate;

the lower cover plate is attached to one surface, which is not contacted with the lower substrate, of the liquid reaction module, and the lower cover plate does not cover the detection pool.

Preferably, the upper cover plate, the upper substrate, the middle partition plate, the lower substrate and the lower cover plate are bonded through hot melt adhesives.

Preferably, the reaction module is composed of a reaction reagent and/or an electrode plate;

when the reaction module is composed of the reaction reagent, a color plate is arranged on the detection chip, a display window is arranged on the detection chip, and the color change of the reaction reagent can be seen from the outside of the detection chip through the display window;

when the reaction module is composed of the electrode plates, the electrode plates are connected with the corresponding detection circuits.

Preferably, the blowing pipe is further provided with at least one reserved air outlet.

A mouth-operated oral cavity detection mechanism is mainly characterized in that the mechanism comprises a hollow blowpipe and a detection chip;

a first opening is formed in the pipe wall of the blow pipe, and a through hole is formed in the blow pipe;

the detection chip is a multi-detection index type chip and comprises a sample inlet hole, a detection shell, a sample inlet channel and at least two detection pools;

the detection shell comprises a base plate, a cover plate and a liquid guide structure insertion piece, a first containing cavity is formed after the base plate and the cover plate are closed, the liquid guide structure insertion piece is arranged on the wall surface of the detection shell, the sample inlet hole is formed in the liquid guide structure insertion piece, the liquid guide structure insertion piece is inserted into the first opening, the size of the first opening is matched with that of the liquid guide structure insertion piece, and the sample inlet hole faces the through hole;

the detection pools are mutually isolated and arranged in the first containing cavity, and each detection pool is provided with a corresponding reaction module;

the sample inlet hole is connected with each detection cell through the sample inlet channel.

Preferably, the blowpipe further comprises a first vent hole, a second vent hole is arranged on the detection shell, and the first vent hole is communicated with the second vent hole;

the detection chip also comprises a base plate with a shaft hole in the center, wherein a plurality of pairs of parabolic runners which are centrosymmetric are arranged on the base plate, a liquid storage tank is arranged in the base plate at a position close to the shaft hole, the sample inlet hole is connected with the liquid storage tank, and the detection tank is arranged in the base plate at a position far away from the shaft hole;

the base plate is also provided with flow channels matched with the detection pools in number, and the liquid storage pools are connected with the corresponding detection pools through the flow channels and the sample feeding channels in sequence;

the first containing cavity is a circular ring-shaped containing cavity, the base plate is sleeved on the mandrel on the base plate through the shaft hole, and a plurality of blades are further arranged on the base plate.

Preferably, the liquid storage tank is arranged in a second cavity in the detection shell, a liquid inlet hole is formed in the second cavity, a liquid inlet channel is further arranged in the detection shell, one end of the liquid inlet channel is connected with the sample inlet hole, and the other end of the liquid inlet channel faces the liquid inlet hole in the second cavity.

Furthermore, a conductive insertion sheet is arranged at the position, opposite to the liquid guide structure insertion sheet, of the outer side of the detection shell;

one of the blades in the basal disc is a metal blade, a metal sheet is further arranged in the detection shell, the conductive insertion sheet is connected with the metal sheet, and the metal sheet is provided with magnetic attraction after being electrified.

An intelligent oral cavity detector is mainly characterized in that the detector comprises a main body, a chip socket, a one-way air outlet valve, a man-machine interaction module, a main control module, a power supply module and a mouth-operated oral cavity detection mechanism;

the chip socket, the one-way air outlet valve, the main control module and the power supply module are all arranged on the main body, and the mouth-operated oral cavity detection mechanism is detachably arranged on the main body;

wherein, the main body is in an arc shape protruding outwards and inwards, and a wearing belt is arranged on the main body;

the blow pipe of the mouth-operated oral cavity detection mechanism is arranged on the inner side of the main body, and one end of a detection chip in the mouth-operated oral cavity detection mechanism, which is not contacted with the first opening, is inserted into the chip socket;

the power supply module is respectively connected with the main control module, the man-machine interaction module and the chip socket;

the human-computer interaction module and the chip socket are connected with the main control module.

Preferably, the detector further comprises:

the human body function signal acquisition module is connected with the main control module;

and the signal transmission module is connected with the main control module and is also connected with an external mobile terminal and/or a cloud server.

Preferably, the human body function signal acquisition module comprises an MEMS detection unit, a heart rate and blood pressure detection unit and a breath sensor detection unit, and the MEMS detection unit, the heart rate and blood pressure detection unit and the breath sensor detection unit are respectively connected with the main control module.

Preferably, the human-computer interaction module is disposed at an outer side of the main body, and the human-computer interaction module includes:

the information prompting unit and the control unit are respectively connected with the main control module.

Preferably, the detector is further provided with a box body, the box body is arranged on the inner side of the main body, and the box body is of an openable structure; the chip socket and the mouth-operated oral cavity detection mechanism are arranged in the box body, the box body is provided with a third opening, the blow pipe penetrates through the third opening, and the one-way air outlet valve is arranged in the box body.

Preferably, the main body is made of flexible materials, a breathable grid is arranged on the main body, and a filter material is further arranged at the position, where the breathable grid is sucked, of the breathable grid.

The mouth-operated oral cavity detection mechanism comprises a hollow blowpipe and a detection chip, wherein a first opening with the size matched with that of the detection chip is arranged on the pipe wall of the blowpipe; the detection chip comprises a sample inlet hole, a sample inlet channel, a detection pool and a reaction module which are arranged in sequence; one end of the detection chip, which is provided with the sample inlet hole, is inserted into the first opening of the blowpipe, when the intelligent oral cavity detector comprising the mouth-operated oral cavity detection mechanism is used for testing, the saliva can be blown to the detection pool by adopting the power of a human body, namely blowing force, so that the detector can conveniently detect the saliva and/or breath, and the equipment cost is further reduced. The intelligent oral cavity detector comprising the mouth-operated oral cavity detection mechanism is compact in structure, attractive and easy to use, can detect information in the oral cavity of a user to detect various early chronic diseases, timely stores and uploads health data of the user, is a portable, convenient, noninvasive, rapid, sensitive and accurate wearable oral cavity detector, and has great social significance, popularization value and good market application prospect.

Drawings

Fig. 1 is a schematic structural view of a mouth-activated oral cavity detecting mechanism according to an embodiment of the present invention.

Fig. 2-1 is a front view of a blow pipe in a mouth-operated oral cavity detecting mechanism according to an embodiment of the present invention.

Figure 2-2 is a top view of the torch of figure 2-1.

Fig. 2-3 are right side views of the torch of fig. 2-1.

Fig. 3-1 is a front view of a blow tube in a mouth-operated oral cavity detecting mechanism according to another embodiment of the present invention.

Figure 3-2 is a top view of the torch of figure 3-1.

Fig. 3-3 is a right side view of the torch of fig. 3-1.

Fig. 4 is a schematic structural diagram of a detection chip in the mouth-activated oral cavity detection mechanism according to an embodiment of the present invention.

Fig. 5 is a schematic structural diagram of a detection chip in a mouth-activated oral cavity detection mechanism according to another embodiment of the present invention.

Fig. 6 is a schematic diagram of a detection chip according to the present invention.

Fig. 7-1 is a schematic structural diagram of a detection chip in a mouth-activated oral cavity detection mechanism according to a third embodiment of the present invention.

Fig. 7-2 is a schematic structural view of a mouth-activated oral cavity detecting mechanism according to a third embodiment of the present invention.

Fig. 8-1 is a schematic structural diagram of the intelligent oral cavity detector of the present invention in an embodiment.

FIG. 8-2 is a left side view of the intelligent oral monitor of FIG. 8-1.

Fig. 8-3 is a schematic structural diagram of a box body in the intelligent oral cavity detector in fig. 8-1.

Fig. 8-4 is a left schematic view of the cartridge in the intelligent oral cavity detector of fig. 8-3.

Fig. 9 is a schematic circuit block diagram of an embodiment of the intelligent oral cavity detector of the present invention.

Fig. 10 is a flowchart illustrating the operation of the intelligent oral cavity detector according to an embodiment of the present invention.

Fig. 11 is a flowchart illustrating the detection process of the intelligent oral cavity detector according to an embodiment of the present invention.

Fig. 12 is a flowchart illustrating communication between the signal transmission module and an external device according to an embodiment.

Reference numerals

1-blowing a pipe; 11-a tube body; 12-a mouthpiece; 13-a first opening; 14-a second opening; 15-a third opening; 2-detecting the chip; 211-sample wells; 212-a sample introduction channel; 213-detection pool; 2141-electrode pad; 215-vent hole; 22-a cover plate; 23-a filter membrane; 24-a substrate; 25-a base plate; 31-upper cover plate; 32-an upper substrate; 33-a middle partition plate; 34-lower substrate; 35-a lower cover plate; 36-enzyme plate; 37-color plate; 4-intelligent oral cavity detector; 41-a filter material; 42-a master control module; 43-an information prompt unit; 44-box cover; 451-intermediate box; 452-two-sided box; 46-one-way gas outlet valve; 47-heart rate blood pressure detection unit; 481 — two-sided chip socket; 482-intermediate chip socket; 49-wear; 50-a chassis; 51-a cover tray; 52-a drainage structure insert; 531-first vent; 532-second vent; 533-a breather pipe; 54-a mandrel; 55-flow channel; 56-blade; 561-metal blades; 57-a base plate; 58-conductive inserts; 59-a liquid inlet channel; 60-liquid inlet hole;

Detailed Description

In order to more clearly describe the technical content of the present invention, the following further description is given with reference to specific embodiments.

The utility model provides a mouth moves formula oral cavity detection mechanism and corresponding intelligent oral cavity detector 4 with low costs, good performance, the production and use of being convenient for to not enough among the prior art.

This mouth moves formula oral cavity detection mechanism, through in the first opening 13 that is equipped with on the pipe wall that will detect chip 2 and insert blowpipe 1, through its structural feature, can just can carry out the collection of saliva and bad breath through human oral cavity power (blowing promptly) in the process, need not extra drive arrangement cooperation and use, effectively reduce equipment cost. Meanwhile, in consideration of sanitation and detection accuracy, the detection chip 2 and the blow pipe 1 are disposable products and are disposable or safely disposed by combustion.

The first opening 13 can be designed as a vertical elastic slit, and a limit protrusion can be designed on the chip, so that the two can be well connected and fixed.

In one embodiment, the detection chip 2 is a flat structure, the first opening 13 is a gap with a size corresponding to that of the detection chip 2, and an interference fit is adopted between the two, so that the detection chip 2 can be tightly combined with the blow pipe 1, the arrangement structure of the blow pipe 1 can be shown in fig. 1, in this embodiment, the blow pipe 1 comprises two parts, namely a pipe body 11 and a blow opening 12, and in other embodiments, the blow pipe 1 can also be an integrated structure. The surface of detection chip 2 be equipped with limit structure for the length that the chip inserted blowpipe 1 is just in time suitable, and this bulk object that detects chip 2 is the chip socket, and accessible chip socket carries on spacingly to the position that detects chip 2, avoids detecting chip 2 and drops from blowpipe 1, and the butt joint gap connection when realizing detecting chip 2 and inserting blowpipe 1 is fixed.

As shown in fig. 2-1 to 2-3, the detection chip 2 is perpendicular to the tube wall of the blowing tube 1, and the level of the inner wall surface of the blowing tube 1 adjacent to the first opening 13 is the lowest, so that saliva can more conveniently flow into the detection chip 2.

As shown in fig. 3-1 to 3-3, the wall of the blowing pipe 1 is further provided with two reserved air holes, namely a second opening 14 and a third opening 15, through which the air blown into the blowing pipe 1 can be transmitted to other sensors connected with the blowing pipe 1, so as to facilitate the detection of more items at the same time.

In one embodiment, the mouth-actuated oral cavity detection mechanism comprises a hollow blow pipe 1 and a detection chip 2, wherein the detection chip 2 is a microfluidic chip;

a first opening 13 with the size matched with that of the detection chip 2 is arranged on the pipe wall of the blowpipe 1, and a through hole is arranged on the blowpipe 1;

the detection chip 2 comprises a sample inlet hole 211, a sample inlet channel 212, a detection cell 213 and a reaction module which are arranged in sequence;

one end of the detection chip 2, which is provided with the sample injection hole 211, is inserted into the first opening 13 of the blow pipe 1, and the sample injection hole 211 faces the through hole.

In this embodiment, the detection chip 2 is perpendicular to the pipe wall of the torch 1, and the horizontal height of the inner wall surface of the torch 1 adjacent to the first opening 13 is the lowest.

In this embodiment, the outer surface of the detection chip 2 is provided with a limiting structure for limiting the length of the first opening 13 of the blow pipe 1 into which the detection chip 2 is inserted.

In this embodiment, the detecting chip 2 is provided with an exhaust hole 215 for exhausting the gas in the detecting cell 213.

In this embodiment, the reaction module is composed of a reaction reagent and/or an electrode sheet 2141;

when the reaction module is composed of the reaction reagent, the detection chip 2 is provided with a color plate 37 (the color plate is a color corresponding plate, and a user can correspond the color of the reaction reagent after being changed with the color on the color plate to judge the detection result), and the detection chip 2 is provided with a display window, so that the color change of the reaction reagent can be seen from the outside of the detection chip 2 through the display window, namely, a plate adjacent to the reaction module can be formed by adopting a transparent material, and an opening can also be arranged on the plate, so that a person can see the color change of the reaction module through the opening; when the reaction module is composed of the electrode pads 2141, the electrode pads 2141 are connected to corresponding detection circuits.

In this embodiment, the tube wall of the blow tube 1 is further provided with at least one reserved air outlet hole.

In this embodiment, when the detecting chip 2 is a chip for detecting saliva, the detecting chip 2 includes a cover plate 22, a filter membrane 23, a substrate 24 and a bottom plate 25; the substrate 24 is provided with a channel with a preset length to form the sample feeding channel 212, two ends of the channel are respectively provided with two openings, and the two openings respectively form the sample feeding hole 211 and the detection cell 213; the bottom plate 25 is arranged on one surface of the substrate 24, and the reaction module is arranged between the bottom plate 25 and the substrate 24 and is contacted with the detection cell 213; the filter membrane 23 covers the other surface of the substrate 24, the cover plate 22 is disposed on one surface of the filter membrane 23 that is not in contact with the substrate 24, and the cover plate 22 does not cover the sample inlet 211.

In this embodiment, the cover plate 22, the filter membrane 23, the base plate 24 and the bottom plate 25 are bonded together by hot melt adhesive.

As shown in fig. 4, in this embodiment, the detection chip 2 is composed of a cover plate 22, a filter membrane 23, a base plate 24, an electrode sheet 2141 and a bottom plate 25, and stacked and adhered in sequence, and the detection chip 2 is a paper microfluidic chip; the channel structure is thin-belt type, and the thin-belt type channel structure is formed by mutually communicating a sample inlet hole 211, a sample inlet channel 212 and a detection cell 213. In the embodiment, the paper microfluidic chip has only one detection cell 213, and the detection cell 213 is connected to a reaction module. As shown in the figure, this detection chip 2 is the vertical channel chip, and it only realizes detecting liquid (saliva), detection chip 2 in each layer sheet material stack in proper order, bond the laminating through the hot melt adhesive and constitute detection chip 2.

The detection chip 2 is of a flat structure, the detection chip 2 comprises a sample inlet hole 211, a sample inlet channel 212, a detection cell 213, an electrode plate 2141 and an exhaust hole 215, the flat sample inlet hole 211 is arranged on a vertical plane in the length direction of the chip, and two side edges of the end surface of the chip are provided with outwards-protruding objects for limiting; the sample to be detected enters the sample channel 212 from the sample inlet 211 and finally flows into the detection cell 213 with the exhaust hole 215 for detection.

In order to make the person skilled in the art better understand the test chip 2 for testing saliva alone, the following will explain the structure, manufacturing process and testing principle of the test chip 2 in the above embodiment by performing blood glucose test:

since the detecting chip 2 is a flat chip, it can be produced without using a sheet in the manufacturing process, and can be produced by using the following materials:

1. four corresponding coils were used: a substrate 24 (PET); a filtration membrane 23 (ultrafiltration membrane); cover sheet 22 (coated paper); a base plate 25 (offset paper); 2. printing electrodes on the base plate: (1) and (3) making an electrode: modifying the electrode by Ni-doped FeS2 powder; (2) counter electrode: a Pt wire electrode; (3) reference electrode: a silver/silver chloride electrode; 3. the size of the detection chip 2 is designed as follows: length: 35 mm; width: 15 mm; thickness: 0.7 mm; limiting size: 3mm isosceles triangles (in other embodiments, other sizes can be adopted according to actual needs); 4. the specific manufacturing process is as follows:

firstly, a saliva channel (i.e. a sample feeding channel 212) with the length of 15mm and the width of 2mm is cut out along the horizontal center line by a hobbing cutter on a substrate with the length of 30 mm. Then, respectively roll-cutting a liquid inlet hole (i.e. a sample inlet hole 211) with phi 5mm and a detection cell 213 with phi 5mm by taking two end points of the sample inlet channel 212 as circle centers;

and secondly, coating hot melt adhesive on the first surface of the substrate, and then compounding and adhering the substrate to the surface of the filter membrane. Then, after the surface of the cover plate 22 is coated with hot melt adhesive and cut off according to the length of 20mm, a 10mm vacancy is reserved at the sampling hole 211, and then the filter membrane is compositely adhered to the second surface of the filter membrane. Then, two exhaust holes 215 with a diameter of phi 1mm are respectively processed on the composite film and at two sides of the detection cell 213 near the saliva channel by using a roller pin (as shown in fig. 4, the chip is provided with 3 exhaust ports on the substrate, the filter membrane and the cover plate 22 in total);

and after the second surface of the substrate is coated with hot melt adhesive, reserving a 10mm vacancy at the position of the bottom plate electrode and then compositely adhering. And finally, rolling and cutting two small triangular limiting protrusions from the positions of 10mm on the two side surfaces of the liquid inlet end of the chip by adopting a hobbing cutter die, and cutting off the chips one by one according to the length of 40 mm.

[ detection instruction: the saliva to be detected enters the sample inlet channel 212 from the sample inlet hole 211 and then flows into the detection cell 213; after the saliva to be detected in the detection cell 213 is in contact reaction with the working electrode, the change of the detection cell 213 is finally caused by the oxidation of the glucose, so that the corresponding detection result can be checked. "C (B)

[ instructions for use: the detection chip 2 is inserted into the blowpipe 1 at the upper end until the two ends of the chip are limited and propped up, and is inserted into the chip socket downwards to be connected with the oral cavity detector system, then the power supply of the oral cavity detector is switched on, and the detection is started along with the system voice prompt step sequence. "C (B)

[ Filter description: the saliva contains more proteins such as digestive enzymes, the ultrafiltration layer is used for filtering high-abundance proteins and mucin in the saliva, so that the separated thin saliva, extracellular fluid and the like can penetrate through the filter layer to enter a detection area for detection. "C (B)

[ description of electrodes: the 1% Ni-doped pyrite type FeS2 enzyme-free electrochemical glucose sensor prepared in this example has a linear detection interval range: 2-16mM glucose; detection sensitivity: sensitivity was 17.67 μ A mM-1cm interference immunity: the anti-interference performance to sodium chloride, uric acid and urea is good in the detection process of glucose. The fitting equation is y-0.01767 x +0.11128, where: x and y are glucose concentration and current value respectively, and the linear correlation coefficient R2-0.99466 is the linear correlation coefficient R2-0.99466. "C (B)

[ principle description: this example uses a method of detecting saliva sugar in the oral cavity to estimate the blood glucose concentration in human blood. "C (B)

If detect other problems, the concrete constitution of response module is adjusted to adaptability (corresponding response module can adopt existing measuring module to constitute among the prior art, the utility model discloses in not innovate the response module of using in the testing process).

In the second embodiment, the structure of the mouth-activated oral cavity detecting mechanism is substantially the same as that of the mouth-activated oral cavity detecting mechanism in the above embodiments, and the difference is only that the detecting chip 2 in the mouth-activated oral cavity detecting mechanism described in this embodiment is a dual-function chip for simultaneously detecting saliva and breath, so only the difference between the two will be described in detail below, and the description of the same parts will not be repeated.

In this embodiment, the reaction module in the detection chip 2 includes a liquid reaction module and a gas reaction module;

the detection chip 2 comprises an upper cover plate 31, an upper substrate 32, a middle partition plate 33, a lower substrate 34 and a lower cover plate 35;

the upper cover plate 31 is provided with a channel with a preset length to form the sample feeding channel 212, one end of the channel is provided with a first opening to form the sample feeding hole 211, the upper cover plate 31 is arranged on one surface of the upper substrate 32, and the upper cover plate 31 does not cover the sample feeding hole 211;

the middle partition plate 33 is arranged on one surface of the upper substrate 32 which is not contacted with the upper cover plate 31, and the gas reaction module is arranged between the middle partition plate 33 and the upper substrate 32 and is connected with the sample feeding channel 212;

the lower substrate 34 is provided with a second opening to form a detection cell 213, and one surface of the lower substrate 34 and the middle partition plate 33 which is not contacted with the upper substrate 32 is attached;

the liquid reaction module is attached to one surface of the lower substrate 34, which is not in contact with the middle partition plate 33;

the lower cover plate 35 is attached to a surface of the liquid reaction module, which is not in contact with the lower substrate 34, and the lower cover plate 35 does not cover the detection cell 213.

In this embodiment, the upper cover plate 31, the upper substrate 32, the middle partition plate 33, the lower substrate 34 and the lower cover plate 35 are bonded together by hot melt adhesive.

In this embodiment, the reaction module is composed of a reaction reagent and an electrode sheet 2141;

the reaction module is provided with a color plate at one side formed by the reaction reagent, a display window is arranged at the corresponding position on the detection chip 2, and the color change of the reaction reagent can be seen from the outside of the detection chip 2 through the display window;

when the reaction module is composed of the electrode plates 2141, the electrode plates 2141 are connected to corresponding detection circuits.

In order to make the skilled person better understand the detection chip 2 for detecting several breath of saliva, the following description is provided to illustrate the structure, manufacturing process and detection principle of the detection chip 2 in the above embodiment by alcohol test:

since the detection chip 2 is also a flat chip, it can be produced without using a sheet in the manufacturing process, and can be produced by using the following materials:

1. six corresponding coils were used: an upper substrate 32(APET), a lower substrate 34(PET), an upper cover plate 31 (double-sided offset paper), a lower cover plate 35(PDMS), a middle partition plate 33 (double-sided offset paper) and a color plate (No. 2 dictionary paper);

an enzyme plate 36 (immobilized enzyme nanofiber membrane) is selected as a reaction module;

(the actual operation is not limited to the selection of the above materials, and can be adjusted according to the actual operation);

2. the electrode is printed on the middle partition plate 33: (1) a working electrode: conductive graphite; (2) reference electrode: silver/silver chloride;

3. the size of the detection chip 2 is designed as follows: length: 40 mm; width: 15 mm; thickness: 1 mm; limiting size: 3mm isosceles triangles (in other embodiments, other sizes can be adopted according to actual needs);

4. the specific manufacturing process is as follows:

firstly, an air inlet hole (i.e. a sample inlet hole 211) with the diameter of 5mm and a sample inlet channel 212 with the width of 3mm are cut on an upper base plate 32(APET) with the length of 40mm by a hobbing cutter. Coating hot melt adhesive on the surface of an upper cover plate 31 (double-sided offset paper), cutting the upper cover plate according to the length of 20mm, and laminating and adhering the upper cover plate 31 (double-sided offset paper) to the first surface of an upper substrate 32(APET) from vacant positions reserved with 10mm at two ends respectively;

secondly, after coating hot melt adhesive on the second surface of the upper substrate 32(APET), adhering the second surface to the first surface (the other end printed with two electrodes) of the middle partition plate 33 (double-sided offset paper);

and then, coating hot melt adhesive on the first surface of the lower substrate 34(PET), adhering the first surface to the second surface of the middle partition plate 33 (double-sided offset paper), and cutting an oval gap with phi 5mm, semi-circles at two ends and a center distance of 20mm on the lower substrate 34 (PET). Then spraying hot melt adhesive on the surface of the enzyme plate 36 (nanofiber membrane), and sticking oval strips with phi 4mm, semi-circles at two ends and 18mm of center distance to oval notches cut on the first surface of the lower substrate 34 (PET). At this moment, a phi 4mm multi-layer through exhaust port is processed at the inner circular arc of the middle part of the upper elliptical enzyme plate 36 (as shown in fig. 5, the chip is provided with 4 exhaust ports on the upper cover plate 31, the upper substrate 32, the middle partition plate 33 and the lower substrate 34);

spraying hot melt adhesive on the surface of the color plate (dictionary paper), covering and adhering the color plate to one side edge of the first surface of the lower cover plate 35(PDMS), spraying hot melt adhesive on the second surface of the lower cover plate 35(PDMS), cutting the color plate according to the length of 30mm, covering and adhering the color plate to the second surface of the lower substrate 34(PET) at the position 10mm away from the liquid inlet hole (namely the sample inlet hole 211);

and finally, rolling and cutting two small triangular limiting protrusions from the positions of 10mm on the two side surfaces of the liquid inlet end of the chip by using a hob, and cutting off the chip piece by piece according to the length of 40 mm.

[ instructions for use: the detection chip 2 is inserted into the blowpipe 1 at the upper end until the two ends of the chip are limited and propped against, and is inserted into the chip socket downwards to be connected with the system, then the power supply of the oral cavity detector is switched on, and the detection is started along with the voice prompt step sequence of the system. "C (B)

[ principle description: the alcohol concentration of the expired gas and the alcohol concentration of the saliva are used as alcohol intake standards, and the alcohol content in the blood and the alcohol content in the breath and the saliva are in a certain proportion in a certain range, and when the alcohol content detection device is used, the alcohol content detection device is respectively contacted with the breath and the saliva through respective channels to generate consistent results of different detection modes. The breath detection is to convert the breath into voltage, filter and amplify the voltage, measure the corresponding voltage, calculate the current generated by the measuring sensor to determine and calculate the corresponding alcohol concentration. The saliva detection is to react ethanol with alcohol dehydrogenase to generate hydrogen peroxide to enable a color developing agent (indigo) to fade, and the alcohol content in the saliva can be obtained by utilizing the fading degree, so that the alcohol content in the blood can be obtained more accurately. "C (B)

[ color plate description: in this embodiment, a "standard color chart corresponding to the immobilized enzyme nanofiber membrane" is adhered to the surface of the chip, the corresponding alcohol concentration (mg/ml) is marked below the color chart, and the user's intoxication degree is determined by the color chart at seven positions of "0, 0.05, 0.1, 0.2, 0.5, 0.8, and 1.0". "C (B)

[ color testing description: this embodiment adopts transparent PDMS diaphragm as the display window that the chip discoloured, pastes the colour chip in the top of detecting layer simultaneously to the chromogenic reaction result of alcohol detection diaphragm is detected with comparing to the observation. "C (B)

In this embodiment, the breath detection part and the saliva detection part are respectively disposed on two sides of the detection chip 2, the two sides are separated by the middle partition plate 33, and on the end face of one end of the dual-function chip, a saliva liquid inlet hole is disposed on the front side, and an air inlet hole is disposed on the back side (i.e., the sample inlet hole 211 includes a liquid inlet hole and an air inlet hole, respectively), so that the detection samples can be introduced simultaneously.

Since the detection chips 2 in the two embodiments are flat, they can be mass-produced, and the schematic diagram during mass production can participate in fig. 6 (each short line segment in the diagram represents one chip), in one embodiment, the chips are made from N kinds of coils with the same width of 250 mm, and 3 rows of 24 chips can be made from 8 coils with the length of 1 meter according to the width of each coil. The linear speed of the die cutting device designed by the embodiment is 30 m/min, so that the yield of the manufacturing method of the embodiment can be calculated as follows: 720 pieces/min. In the processing process, materials of all layers of the detection chip 2 are bonded by hot melt adhesive, and the method has the characteristic of high bonding speed.

The specific processing steps can refer to the following processing steps:

firstly, mounting a plurality of rolls of various coiled materials with equal width on a plurality of stations on a machine, respectively performing rolling cutting and gluing processing and forming; step two, cutting a plurality of functional areas on the chip base material film by adopting a hob cutter; thirdly, coating hot melt adhesive on the chip substrate film by blade coating, and respectively pressing and sticking the hot melt adhesive to form a composite layer; fourthly, in the cut fluid channel, a trace amount of reagent is sprayed out along the linear fluid channel by adopting a trace amount/spraying/dropping liquid/metering valve/sample application equipment/spray head and is injected into the paper microfluidic chip; step five, scraping and coating hot melt adhesive on the chip bottom plate, and then laminating and adhering the chip bottom plate with the composite base and the composite cover plate; and step six, cutting off the composite adhered chip coiled material piece by adopting a hob according to the length of each piece.

In the two embodiments, the manufacture and the use of the mouth-activated oral cavity detection mechanism combine the microfluidic technology, the die cutting (molding) technology, the hot melt adhesive spraying technology and the biochemical technology. The construction and application of the mouth-operated oral cavity detection mechanism introduce the function of an external force field, so that the processes of cell separation, chemical reaction and the like and the detection and analysis of biological information are automatically and efficiently and quickly carried out on the detection chip. In the using process, a saliva spitting-promoting and continuous blowing mode is adopted, the blowing force of a saliva sample and breath gas at a mouth, the gravity of saliva, the capillary permeability of paper and the pressure exerted by a chip on a microfluidic cavity under the action of centrifugal force are used for controlling the flow of microfluid and gas, so that the whole detection is efficiently and quickly realized.

In the third embodiment, the mouth-activated oral cavity detecting mechanism is different from the mouth-activated oral cavity detecting mechanisms in the two embodiments, but as can be seen from fig. 7-1 and 7-2, the mouth-activated oral cavity detecting mechanism in this embodiment still includes the hollow blowing tube 1 and the detecting chip 2, and a part of the detecting chip 2 can be inserted into the first opening in the blowing tube 1, so that saliva entering the blowing tube 1 from the through hole can well enter the detecting chip 2, and meanwhile, the detecting chip 2 has some common points with the detecting chip 2 mentioned in the two embodiments, and for the common points, description is not repeated, but some differences are described below:

as shown in fig. 7-1 and 7-2, the mechanism comprises a hollow blow pipe 1 and a detection chip 2; a first opening 13 is arranged on the pipe wall of the blow pipe 1, a through hole is arranged on the blow pipe 1, and a reserved air outlet can also be arranged on the blow pipe 1;

the detection chip 2 is a multi-detection index type chip, and the detection chip 2 comprises a sample inlet 211, a detection shell, a sample inlet channel 212 and at least two detection pools 213;

the detection shell comprises a base plate 50, a cover plate 51 and a liquid guide structure insertion piece 52, wherein a first containing cavity is formed after the base plate 50 and the cover plate 51 are closed, the liquid guide structure insertion piece 52 is arranged on the wall surface of the detection shell, the sample inlet hole 211 is arranged on the liquid guide structure insertion piece 52, the liquid guide structure insertion piece 52 is inserted into the first opening 13, the size of the first opening 13 is matched with that of the liquid guide structure insertion piece 52, and the sample inlet hole faces the through hole; the liquid guide structure inserting piece 52 can also be provided with a limiting projection for limiting the connection between the liquid guide structure inserting piece and the blow pipe 1;

each detection cell 213 is isolated from each other and arranged in the first cavity, and each detection cell 213 is provided with a corresponding reaction module;

the sample inlet 211 is connected to each of the detecting cells 213 through the sample inlet channel 212.

In this embodiment, the lance tube 1 further comprises a first vent hole 531, a second vent hole 532 is arranged on the detection housing, the first vent hole 531 is communicated with the second vent hole 532, and in this embodiment, the first vent hole 531 and the second vent hole 532 are connected through a vent pipe 533;

the detection chip 2 further comprises a base plate 57 with a shaft hole in the center, a plurality of pairs of centrosymmetric parabolic runners 55 are arranged on the base plate 57, a liquid storage tank is arranged in the base plate 57 close to the shaft hole, the sample inlet hole 211 is connected with the liquid storage tank, and the detection tank 213 is arranged in the base plate 57 far away from the shaft hole;

the base plate 57 is also provided with flow channels 55 the number of which is matched with that of the detection cells 213, and the liquid storage cells are connected with the corresponding detection cells 213 through the flow channels 55 and the sample introduction channels in sequence;

the first cavity is a circular cavity, the base plate 57 is sleeved on the mandrel 54 on the base plate 50 through the shaft hole, the base plate 57 is further provided with a plurality of blades 56 (the number of the blades is preferably more than 10), a user can blow air to the blow pipe 1, the air is blown into the first cavity through the vent pipe 533 and blown to the blades 56 to drive the base plate 57 to rotate, and accordingly saliva in the liquid storage pool flows into each detection pool 213 along the parabolic flow channel 55.

The liquid storage tank is arranged in the second accommodating cavity in the detection shell, the volume of the second accommodating cavity can be slightly smaller, so that the detection requirement can be met by adopting saliva as less as possible when the liquid storage tank is used, a liquid inlet hole is formed in the second accommodating cavity, a liquid inlet channel 59 is further formed in the detection shell, one end of the liquid inlet channel 59 is connected with the sample inlet hole, and the other end of the liquid inlet channel 59 faces the liquid inlet hole in the second accommodating cavity.

In this embodiment, a conductive insert 58 is disposed at a position opposite to the liquid guide structure insert outside the detection housing;

one of the blades in the base plate is a metal blade 561 which cannot be attracted by a magnetic metal sheet, a metal sheet is further arranged in the detection shell, the conductive insertion sheet 58 is connected with the metal sheet, and the metal sheet is provided with a magnetic attraction function to attract the metal blade 561 after being electrified.

This arrangement allows the blade 561 to be attracted by the blade when power is applied to the blade via the conductive insert 58 so that the inlet channel 59 is well aligned with the inlet opening and saliva can flow well into the reservoir. In this embodiment, as shown in fig. 7-2, a blade disposed opposite to the liquid inlet is provided as a metal blade 561, and the metal blade is disposed directly above the conductive insert 58, and the conductive insert 58 can be inserted into the middle chip socket 482 of the intelligent oral cavity detector. In this embodiment, the conductive insert 58 is located on the outside of the tray, and the inlet channel 59 is located on the inside of the tray and connected to the conductive insert.

The detection chip 2 is a centrifugal parabolic chip with a plurality of detection cells 213, and the active microfluidic chip with a plurality of channels and a plurality of detection cells 213, which has a centrifugal function, can be used for rapidly and simultaneously detecting a plurality of subjects.

For the sake of easy understanding, the mouth-activated oral cavity detecting mechanism mentioned in the above embodiments is described below with reference to a specific example:

1. the base plate 57 is made of acrylic material; polyvinyl chloride is used for forming the cover disc 51; bleached kraft wood pulp is used to form the chassis 50;

2. a reaction module is adopted, which can detect the following items: firstly, uric acid; ② myoglobin; ③ AIDS; fourthly, human fatigue; (in actual test, other reaction modules can be replaced according to actual requirements)

3. The size of the detection chip 2 is designed as follows: chip outer diameter: phi 5 cm; thickness of the chip: 20 mm; chip structure: a disc;

4. the specific manufacturing process is as follows:

firstly, a compression molding process is adopted to manufacture a circular chassis 50 with a mandrel 54 and an outer diameter phi of 5 cm;

secondly, an injection molding process is adopted to manufacture a circular base plate 57 with a shaft hole, 4 groups of parabolic flow channels 55 which are centrosymmetric are arranged on the surface of the base plate 57, an annular liquid storage tank is arranged at the position close to the axial center of the base plate 57, a sample injection channel 212 is arranged on the circumference of the base plate 57, a flat liquid guide structure insertion sheet 52 is injected at the upper end of the edge of the chip cover plate 51, a flat conductive insertion sheet 58 is injected at the lower end of the edge, and the conductive insertion sheet 58 is connected with a metal sheet with magnetism after electrification. 4 detection cells 213 are arranged on the side surface of the disc of the base disc 57; the reagents (i.e. the reaction modules formed by the reaction reagents) in the detection cell 213 are all stored in a freeze-drying or air-drying manner, and sealed by a transparent plastic cover with a buckle, N wind blades 56 (only 2 blades are drawn in the figure) which are close to the shell and are above the pick-up blade are arranged on the circumference of the base plate 57, and a metal blade 561 is arranged at the far end of the liquid inlet hole. The circular base plate 57 is then mounted on the mandrel 54 of the circular base plate 50 and locked with double nuts (so that the base plate 57 can easily and freely rotate on the mandrel 54). And finally, coating the ultralow-temperature hot melt adhesive on the outer edge of the injection-molded transparent chassis 50, and then sleeving and bonding the injection-molded transparent chassis with the circular cover disc 51 through an arc.

[ instructions for use: firstly, the flat liquid guide structure insertion piece 52 at the upper end of the chip cover disc 51 of the embodiment is inserted into the blow pipe 1 until the circumference of the chip is propped, then the flat conductive insertion piece 58 at the lower end is inserted into the lower chip socket, then the power supply of the using device is switched on, the detector device is shaken to ensure that the blade with the metal sheet at the edge of the chip generates magnetism after being electrified and attracts the metal blade to the position corresponding to the metal sheet in the chip so as to ensure the accurate butt joint of the sample inlet and the sample inlet channel, and then the system can start detection by voice prompt step by step. After the sample enters the liquid storage tank of the chip along with the sample injection, the centrifugal blowing channel on the edge of the blowing pipe blows air, the N fan blades 56 on the edge of the base plate 57 on the chip are blown by the air to rotate rapidly to generate centrifugal force, so that the sample injection in the liquid storage tank flows into each detection tank 213 along the parabolic flow channel 55, and the reagent which is lyophilized or air-dried is rapidly mixed by the sample injection to generate a detection result after chemical change. "C (B)

[ description of liquid flow: in the chip of this embodiment, the sample inlet 211 vertically arranged outside the circumference of the cover disc 51, the liquid inlet channel arranged inside the cover disc 51, the liquid inlet hole arranged on the base disc 57 and the annular liquid storage tank arranged on the side surface of the base disc 57 are communicated; and the outlet of the reservoir is connected to the inlet of the detection cell 213 via a spiral flow channel 55. "C (B)

[ principle description: the utility model discloses a centrifugal detection device can realize utilizing the liquid stream to drive the liquid stream in radial (centrifugal force), tangential (euler force), the control of normal direction (gravity) to single or multinomial survey, has huge advantage in integrating the miniflow chip that height, size are little, material and structure are complicated. "C (B)

The blow pipe 1 mentioned in the above embodiments may be a plastic blow pipe 1, which is a cylindrical plastic pipe with a through hole at one end and a closed hollow end, and the two side surfaces of the closed end of the plastic pipe are provided with vent holes, and a diversion outlet with a transverse gap (i.e. a first opening 13) is arranged below the through hole end. The detection chip 2 is a mouth-operated chip (self-driven by manpower), and when in use, the flow and reaction of a sample in the micro-fluidic chip are automatically controlled by means of human body power.

The following table 1 shows the main differences between the detection chip 2 of the mouth-actuated oral cavity mechanism of the present invention and the active (passive) microfluidic chip of the prior art:

TABLE 1

From last table 1 compare the centering not difficult discovery the utility model provides a detection chip sees from the aspect of material, structure and processing technology, its with low costs and preparation are simple and convenient, need not complicated peripheral equipment, the loss of process step when can saving good many detections, still can reduce the waste of good many accessories and auxiliary materials, more can avoid being surveyed the pollution of sample testing in-process to the realization is detected active control and the fast flow of sample, has fine price/performance ratio. The problem that the 'active chip' must use micro-motor or micro-pump to provide driving source for liquid flow can be eliminated, and the purpose of disposable, low-cost and portable analysis can be carried out in real sense, and the principle is as follows:

the chip is vertically arranged on the blowpipe 1, and saliva is powered by gravity and blowing force and quickly falls into the detection pool; meanwhile, the saliva is dropped and rapidly rotated and thrown by gravity, blowing force and centrifugal force; the saliva flies to the liquid inlet hole and enters the detection pool by blowing pressure; the saliva and breath to be measured in the chip are all about 37 degrees (body temperature) and are isolated from the outside by the shell of the detector.

The mouth-activated oral cavity detection mechanism in the above embodiments is used as a part of an oral cavity detector in actual use, when the mouth-activated oral cavity detection mechanism in any of the above embodiments is applied to the intelligent oral cavity detector 4 for use, the intelligent oral cavity detector 4 further includes a main body, a chip socket, a one-way air outlet valve 46, a human-computer interaction module, a main control module 42 and a power module, and the specific structure thereof can be shown in fig. 8-1 and 8-2, the intelligent oral cavity detector 4 is a wearable device, and the selected chips are small-sized and portable chips;

the chip socket, the one-way air outlet valve 46, the main control module 42 and the power supply module are all arranged on the main body, and the mouth-operated oral cavity detection mechanism is detachably arranged on the main body;

wherein, the main body is convex and concave arc, and the main body is provided with a wearing belt 49, and the wearing belt 49 is connected with the two sides of the main body;

in this embodiment, the main body may be formed by an outer convex and inner concave arc-shaped shell made of liquid silica gel,

the blow pipe 1 of the mouth-operated oral cavity detection mechanism is arranged on the inner side of the main body, and one end of a detection chip in the mouth-operated oral cavity detection mechanism, which is not contacted with the first opening 13, is inserted into the chip socket;

the power supply module is respectively connected with the main control module 42, the human-computer interaction module and the chip socket;

the human-computer interaction module and the chip socket are connected with the main control module 42.

In this embodiment, the mouth-operated oral cavity detection mechanism is arranged in the middle of the main body, and the blow pipe 1 and the detection chip in the mouth-operated oral cavity detection mechanism are disposable articles, so that the mouth-operated oral cavity detection mechanism is mounted on the intelligent oral cavity detector 4 when in use, and can be taken down from the intelligent oral cavity detector 4 when not in use or after the detection is finished.

The main control module 42 is used as a signal processing module to process signals of each module in the intelligent oral cavity detector 4 and perform centralized management on the modules, the STM32F103CBT6 single chip microcomputer of ST company is adopted in the embodiment to form main components of the main control module, the main components are 32-bit single chip microcomputers, the internal resources are rich, the use requirement of the system is met, 48-pin SOP packaging is adopted, the size is relatively small, and the main control module is a microcomputer module.

The microcomputer module comprises a signal acquisition circuit, a digital-to-analog conversion circuit, a signal processing circuit and a signal output circuit. The signal acquisition circuit is used for acquiring detection data of the detection module; the digital-to-analog conversion circuit performs digital-to-analog conversion on data acquired by the signal acquisition circuit, transmits the data to the signal processing circuit for analysis, and converts an analysis result into visual data through the signal output circuit and outputs the visual data to the signal display module, the mobile terminal and the cloud server on the detector.

In addition, the main control module can also comprise a USB interface, and in practical use, the microcomputer module can be arranged in the theme, and the USB interface is arranged on the outer surface of the main body.

The power module can be composed of one or more power supply units of graphene solid-state thin-film batteries, Na-CO2 batteries, porous nickel fluoride thin-film batteries, ultrathin flexible battery FLCB batteries, paper battery units, solid rechargeable batteries and the like.

In this embodiment, the detecting apparatus further includes:

the signal transmission module is connected with the main control module and is also connected with an external mobile terminal and/or a cloud server.

The oral cavity detector is characterized in that the external mobile terminal is internally provided with a WeChat applet data communication or a WeChat public number data communication, data collected by a detection chip and a human body function signal acquisition module in the oral cavity detector can be transmitted to the mobile terminal and a cloud server through a signal transmission module, corresponding data can be transmitted to the main control module at the same time, the main control module controls an information prompt unit 43 in the human-computer interaction module to display the data, and the display module can be directly installed on the main body or can perform data interaction with the main control module in the main body through a wired and wireless transmission method.

In this embodiment, the collected information can be displayed on the signal display module, the mobile terminal and other devices; meanwhile, operation records and monitored voltage and current change data can be uploaded to the cloud server through the mobile terminal and recorded.

In this embodiment, the signal detection function module is composed of a detection chip in the mouth-operated oral cavity detection mechanism, an MEMS detection unit in the human body function signal acquisition module, a heart rate and blood pressure detection unit 47, and an oral cavity sensor detection unit.

In an embodiment, the schematic diagram of the circuit modules of the intelligent oral cavity detector 4 can be seen in fig. 9, which illustrates a circuit connection relationship among some of the major modules of the intelligent oral cavity detector 4, and includes a main controller (STM32F103CBT6) in the main control module, a power module, a display subunit, a key input subunit, a heart rate and blood pressure detection unit 47, an MEMS detection unit, a detection chip (which is a microfluidic chip), and an oral cavity sensor detection unit, and it can be seen from the drawing that the power module, the display subunit (which may be formed by an OLED display unit), the key input subunit, the heart rate and blood pressure detection unit 47, the MEMS detection unit, the detection chip, and the oral cavity sensor detection unit are all connected to the main controller; the MEMS detection unit is used for realizing temperature and humidity, air pressure detection and VOS breath detection, the detection chip can be used for detecting saliva sugar, alcohol, uric acid and myoglobin, and the breath sensor detection unit is used for realizing comprehensive breath detection.

The key input subunit and the OLED display unit (display subunit) provide a man-machine interaction interface, and the graphical representation can be selected and various measurements can be started through key operation. Adopt 64X 48 dot matrix OLED display screen as the display element, its advantage lies in that the power consumption is lower, and small to adopt I2C bus communication mode, it is few to occupy the singlechip bus, is fit for using on this embodiment wearable equipment.

In this embodiment, the breath sensor detection unit may be constituted by an acetone detection sensor and an isoprene gas sensor.

In this embodiment, when the detection chip in the mouth-activated oral cavity detection mechanism described in the above embodiments is used in the intelligent oral cavity detector 4, the detection chip cooperates with the main controller (STM32F103CBT6), the power module, and the human-computer interaction module to implement corresponding detection, and when the reaction module is composed of the electrode sheet 2141, the purpose of measuring the detected sample is achieved by designing a voltage scanning and transmitting circuit, a constant potential circuit, and a micro-current detection circuit required for the test.

Because the detection system only needs to display Chinese (English) welcome words, voltage data, units, disease characteristic prompts and the like, the detection system can work at +5V voltage by adopting a character type OLED micro display screen. The functions to be completed are as follows: thereby obtain required voltage signal through the real-time gauze mask scanning voltage circuit of SPI interface, gather the current signal after the processing through the AD conversion chip of 12C interface.

The power supply voltage of the STM32F103CBT6 chip in the intelligent oral cavity detector 4 is 3.3V, and the ASM1117-3.3V chip is used for realizing the conversion from 5V to 3.3V. The frequency of the crystal oscillator used was 8.0 Mhz.

The heart rate and blood pressure detecting unit 47 can be respectively composed of a heart rate detecting chip and a blood pressure detecting chip,

the heart rate detection chip can be formed by a MAX30102 chip, and the MAX30102 chip is a module of an integrated heart rate monitor and a pulse oximeter biosensor. It integrates multiple LEDs, photodetectors, optics, and low noise electronic circuits with ambient light rejection. The power consumption of this kind of pulse blood oxygen and heart rate monitoring integrated sensor module is extremely low, and perfect system scheme effectively saves space, simplifies the design flow of smart mobile phone and wearable equipment. The MAX30102 uses a 1.8V power supply and a separate 5.0V power supply for internal LEDs, standard I2C compliant communication interface. The standby current is zero through the software turn-off module, and the power supply can be always maintained in a power supply state.

The MAX30102 has different working modes, can work in a blood oxygen mode and a heart rate mode, and is internally provided with a FIFO (first in first out) which can store up to 32 sampling data, so that the processor does not need to read the chip data after each sampling, but reads the data when the FIFO is full.

The blood pressure detection chip can be formed by an MPXV5050GP piezoelectric sensor produced by Freecal company, and can be placed at a position close to the cheek on the inner side of a main body, so that the pressure of the blood of the facial artery on the blood vessel wall can be directly converted into an output electric signal.

The signal acquisition module in the intelligent oral cavity detector 4 is electrically connected with the signal display module, the signal processing module, the wireless signal transmission module and the power supply module; the detector is connected with the mobile terminal and the cloud server through a wireless network.

In this embodiment, the detecting apparatus is further provided with a box body, the box body is arranged on the inner side of the main body, and the box body is of an openable structure; the chip socket and the mouth-operated oral cavity detection mechanism are arranged in the box body, the box body is provided with a third opening, the blow pipe 1 penetrates through the third opening, and the one-way air outlet valve 46 is arranged in the box body.

In this embodiment, the human body function signal acquisition module includes an MEMS detection unit, a heart rate and blood pressure detection unit 47 and an oral cavity sensor detection unit, and the MEMS detection unit, the heart rate and blood pressure detection unit 47 and the oral cavity sensor detection unit are respectively connected to the main control module.

In this embodiment, the box comprises three parts, namely a middle box body 451 and two side box bodies 452, the mouth-activated oral cavity detecting mechanism is arranged in the middle box body 451, the MEMS detection unit and the breath sensor detection unit are respectively arranged in the box bodies 452 on the two sides, namely, the two air outlets are respectively arranged at the left side and the right side of the mouth-operated oral cavity detection mechanism, two reserved air outlets are arranged on the pipe wall of the blowing pipe 1, the air outlets can be led to the box bodies 452 at the two sides through the two reserved air outlets, the MEMS detection unit and the breath sensor detection unit can perform the detection function together with the detection chip, and the sensors can be arranged in a box body considering that the detection environment is higher, particularly, the box bodies 452 at the two sides are provided with the air permeable grids and filled with water absorbing filter materials, thereby avoiding the conditions of humidity and the like from influencing the performance of the sensor, the structure can be seen from fig. 8-3 and 8-4, which are schematic diagrams of the box body in which the mouth-activated oral cavity detecting mechanism is placed.

Through the airtight connection of the box body, the design of filtering with water vapor and arranging the one-way air outlet valve 46, the problem that the existing MEMS sensor fails due to water vapor invasion and plastic silica gel vapor adsorption can be effectively solved.

The box body can be made of ABS materials and is embedded in the inner side of the main body of the intelligent oral cavity detector 4, the main body of the intelligent oral cavity detector 4 is an arc-shaped shell, the shape of the box body is matched with that of the main body, a closed arc-shaped box cover 44 which is convex and concave and is elliptical and arc-shaped up and down and a detachable box body which is connected with three buckles at the left, the middle and the right below are arranged, the box cover 44 is hinged on the box body at the lower part, the center at the lower part of the box cover 44 is exposed, the lower parts at the left and the right sides are provided with breathable grids and filled with water-absorbing filter materials, and a circular plastic; the upper part of the box body is hinged and communicated with the box cover 44, the middle part is open front and back, the left side and the right side are respectively and independently sealed, and the box body is provided with one-way air outlet valves 46 in opposite directions, and the three parts of the box body are respectively provided with a special circuit socket, namely a middle chip socket 482 and two side chip sockets 48 which are respectively used for being matched with a detection chip, an MEMS detection unit and an oral air sensor detection unit in the mouth-operated oral cavity detection mechanism to work.

In practical use, the mouth-activated oral cavity detection mechanism can be a saliva detection device for detecting RNA, DNA, enzymes, antigens, antibodies and hormones;

the MEMS detection unit and the breath sensor detection unit can respectively form a temperature, humidity, TVOC, carbon dioxide, alcohol and carbon 13 detection submodule arranged on the left side of the intelligent oral cavity detector 4 and a plurality of chronic diseases and early cancer (a plurality of) marker detection submodule arranged on the right side of the intelligent oral cavity detector 4.

In this embodiment, a bosch BME680 sensor is selected to form a MEMS detection unit, which is a four-in-one MEMS sensor.

Referring to fig. 10, the working flow of the intelligent oral cavity detector 4 in this embodiment can be seen, when the intelligent oral cavity detector 4 executes a full acquisition mode, the design of the main controller adopts a modular hierarchical programming concept, which is mainly divided into a bottom driver and a top application (the corresponding program is a program in the prior art), and the bottom driver mainly includes: simulating I2C bus equipment drive, OLED liquid crystal module drive, AD conversion program, SMBus drive program, the top program mainly includes: blood pressure extraction program, body temperature, humidity, air pressure, VOS comprehensive breath data reading and converting program, saliva sugar, alcohol conversion and the like. The vital sign parameter data supported by the using device is collected and transmitted to the external connection equipment through the Bluetooth module.

Referring to fig. 11, after the power is turned on, the system is initialized, and then a major cycle is started, wherein basic data of a human body needs to be acquired, converted and displayed in the major cycle (data of the body temperature, the oral cavity humidity, the oral cavity air pressure and the VOS integrated breath can be directly read through a bosch BME680 sensor interface function), blood pressure data needs to be read through an I2C bus, and other health data needs to be acquired by reading sampling data of a detection chip (i.e., a microfluidic chip) in a mouth-operated oral cavity detection mechanism.

Meanwhile, the read sampling data has interference and fluctuation, so the data processing is needed to extract the instant blood pressure value of the human body. The micro-fluidic chip detection system of the embodiment starts measurement only when needed and is controlled by a key.

The microfluidic chip of this example is provided for a single use only. When a user installs the microfluidic chip on the blow tube 1, installs the blow tube 1 and connects the chip circuit, the user presses the button to start the detection.

When a user detects the alcohol concentration, the control module of the system samples the gas in the alcohol sensor only when the expiratory pressure in the chip reaches a certain value, so that the effectiveness and the accuracy of sampling are guaranteed.

In other embodiments, the human body function signal acquisition module may be formed by one or a combination of multiple sensors of an MEMS conductive gas sensor, a nano-film, a graphene biosensor, an electrochemical sensor, a skin myoelectric activity sensor, a temperature and humidity sensor, and a multifunctional composite sensor.

In this embodiment, the human-computer interaction module includes: the information prompting unit and the control unit are respectively connected with the main control module.

The information prompt unit can be composed of a display subunit and a voice playing subunit,

the display subunit can be composed of any one of a sirocco paper display screen unit, an AMOLED or OLED touch display screen unit and an MEMS interactive projection unit;

the voice playing subunit comprises a voice output subunit which is composed of a micro loudspeaker; the control unit comprises a key input subunit and a voice input subunit; the key input subunit comprises a menu key, a power on/off key and the like;

the voice recognition subunit consists of a voice acquisition module, a voice pre-stage processing module, a voice training module, a voice recognition module, a voice prompt module and an output recognition module which are connected in sequence.

The working principle of the man-machine interaction module and the wireless communication module forming the signal transmission module in the embodiment is as follows:

the voltage number obtained by the detection circuit in the detection system is designed to be displayed by an OLED display screen and transmitted to the mobile terminal in real time for an operator to check and record (after the user is controlled to operate according to the voice prompt of the system, the system prompts the detected concentration of the saliva sugar/alcohol). In the period of data exchange, a standard voice prompt set by a system and a method for generating an instruction by a user to answer are adopted, and then human-computer interaction is realized through a wireless module and a display module, and data transmission and storage are realized through the wireless module.

The wireless communication module can be a core component formed by an nRF24L01 chip, and a simple resistor, a capacitor and a crystal oscillator are matched at the periphery of the wireless communication module, so that a simple PCB antenna is drawn to form a wireless communication scheme.

In specific implementation, the Bluetooth module can be adopted to form a signal transmission module, and the Bluetooth module is adopted to realize data exchange with external equipment with an embedded Bluetooth function. In order to reduce the volume of the system, lighten the mass of the system and reduce the power consumption, the Bluetooth module adopts a Class-2 design scheme, USB output is realized, the transmission distance is 10m, and the requirement of the system can be met by supporting a Bluetooth 2.0 version protocol. The Bluetooth module is formed by a BC417413 chip of CSR company. The front-end radio frequency band pass filter selects MDR771F-CSR-T, and the balun adopts HHM-1517 of TDK company to complete the conversion between the differential radio frequency signal of the system and the input and output signals of the antenna. The detection result can be transmitted to the mobile terminal and the electronic health record of the patient in real time, and each nursing center can be ensured to obtain important information immediately.

The process of the communication between the signal transmission module and the external device can be seen in fig. 12, and the external device (i.e., the external mobile terminal) can remotely control the device used in the embodiment to work in a full collection mode, so that various physiological indexes collected by the device can be stored on a terminal display screen in real time and can be conveniently checked later. If necessary, the acquired data can be sent to a remote doctor through a wireless network and an Intemet network, so that remote monitoring is realized. When the key physiological index of the user is smaller than or larger than a certain critical point, the external equipment can send the acquired data and the GPS information to a preset emergency contact person in a short message mode and dial the number, so that the emergency contact person can know the physical condition of the user at the first time, and can take rescue measures in time, the life safety of the wearer is protected, and the external equipment is suitable for the person suffering from the sudden disease.

To overcome the main disturbances of the present detection system: power supply and electrochemical noise, this embodiment introduces software filtering processing algorithm (by modifying the parameters, writing related programs to achieve the effect of noise elimination). And filtering sharp pulses and long-duration interference in the input signal by adopting a depolarization average filtering algorithm so as to enable data transition to be smooth.

In this embodiment, the main body is made of a flexible material, the main body is provided with an air permeable grid, the air permeable grid is further provided with a filter material 41 at a position where air is sucked, the filter material 41 can be made of an air filter material and an activated carbon filter material, wherein the activated carbon filter material can be directly placed through the arrangement of an inner grid and an outer grid, and both the activated carbon filter material and the air filter material can be made into a film shape and arranged in the main body.

The comfort of wearing the device is considered, and meanwhile, the processing of the vital sign data cannot be influenced. Therefore, the circuit board adopted in the utility model is composed of flexible circuit boards.

The intelligent oral cavity detector 4 in the above embodiment is a detection product developed for personal physical examination, and is a head-wearing detection-purpose device which is safe, reliable and convenient to wear. By collecting oral information and recording the change condition of the related resistance in real time, the colorful voice training software can facilitate the study, operation and use of the vast users. The health data can be displayed through the display screen, the health data of the user can be known in real time through the mobile terminal (or the tablet personal computer), and information such as sub-health state, early cancer and the like of the user can be collected. The detected data is transmitted in a Bluetooth mode.

After the Bluetooth device on the intelligent oral cavity detector 4 is associated with software on the mobile terminal, the detection data can also be transmitted to the computer terminal of the doctor. After professional data analysis and diagnosis are completed by a doctor according to data collected by the detector, more related common knowledge about diseases is obtained through interaction with an expert, a detailed disease treatment and suggestion report is fed back to a mobile phone of a user, and after the Bluetooth is matched with the mobile phone, the doctor can realize near-remote uninterrupted tracking and monitoring of subsequent rehabilitation progress of the patient through the intelligent oral detector 4 in the technical scheme of the application, and find potential risk factors and dynamically evaluate the curative effect of a medicament in time, namely the intelligent oral detector 4 can be combined with the cloud technology, upload and store the data to the cloud end of a tri-hospital which is used for on-line combined medical treatment through a Bluetooth lamp device, so that personal health data is established, the health data of the user can be conveniently inquired by the doctor and other users allowed to access, the health condition and the trend of the user can be visually shown, and the user can be, provides health analysis and health promotion suggestions, and achieves better effects of preventing and monitoring chronic diseases. And the data and the diagrams can be shared in a cloud, can be quickly derived when a doctor is hospitalized, and can be used for making detailed reference for diagnosis of the doctor. The detector communicates with the APP and the hospital of a user through a Bluetooth device, and a medical service closed-loop ecological chain of detection, treatment, rehabilitation and monitoring is formed. And a set of specially designed mobile phone APP software can form a complete intelligent medical detection system.

The bluetooth device on the intelligent oral cavity detector 4 also uploads and stores data to the health service system on the network big data platform. The health data service system carries out statistical extraction on efficiency management, health management, personal preference life and work behaviors and the like of a user through collection, sorting, filtering, judgment, analysis, feedback and the like, provides intervention suggestions to a certain extent, and enables big data to serve individuals better.

In the embodiment, the detection chip in the mouth-operated oral cavity detection mechanism precisely integrates the functions of sample collection, enzymatic conversion, electrochemical analysis, mobile phone signal storage, data processing and the like into a miniaturized biosensor system. In the corresponding embodiment, the detection method combining electrochemistry and detection reagent is adopted, the wiring terminal of the detection electrode is communicated with an external power supply, and the reaction end is close to the independent sample feeding channel 212. After the sample to be detected in the sample feeding channel 212 contacts and reacts with a reaction reagent or an electrode, color change is generated after the reaction of the reagent, or resistance on a chip circuit changes, and the change is detected by a voltage signal amplifying circuit, so that a corresponding voltage pulse signal is generated to obtain a corresponding detection result.

The mouth-operated oral cavity detection mechanism mentioned in the above embodiments can detect various early chronic diseases by inserting the detection chip into the first opening 13 arranged on the tube wall of the blow tube 1 and matching with the corresponding intelligent oral cavity detector 4, and can detect various early chronic diseases by information in the oral cavity of a user, and can detect through human oral cavity power (namely air blowing) in the using process without matching with additional driving equipment, and the detection chip and the blow tube 1 are disposable products, so that the mouth-operated oral cavity detection mechanism is cleaner, prevents cross infection, is more sanitary, and has lower cost.

The utility model has unique structure, can directly collect the saliva and the breath, creates an integrated micro-fluidic chip (namely a mouth-operated oral cavity detection mechanism) originally, adopts the vertical input of the chip, the saliva blowing pipe 1, the breath blowing and the centrifugal mixing, and can better collect the saliva and the breath; the detection chip for screening multiple chronic diseases and early cancers by adopting N chips can adopt a disposable chip and a reusable chip to meet different requirements, and adopts the sanitary non-invasive detection of a disposable saliva (breath) blowpipe 1, so that the detection chip is more sanitary; and the cost is low, the purchase is easy, and the paper chip is adopted, so that the paper chip can be safely treated by combustion after being used, and the environment is protected.

To sum up, the utility model provides a but mouth moves formula oral cavity detection mechanism automated mass production, production efficiency is high, the processing cost is low, production quality is more stable and do not relate to precision finishing, makes the work that originally needs to be accomplished in a laboratory can be accomplished on a chip, has simplified the manufacturing process of micro-fluidic chip moreover greatly and greatly reduced micro-fluidic chip's cost of manufacture, all obtains the effect of ideal in the aspects such as sensitivity, the degree of accuracy, test linearity and test that detect.

The micro-electrode micro-fluidic chip is matched with other parts in an intelligent oral cavity detector for use, information in the oral cavity of a user can be simply controlled and detected through a user mobile terminal and a voice recognition function to detect various early chronic diseases, health data of the user can be stored and uploaded in time, when the micro-electrode micro-fluidic chip is used, the health state of the user can be analyzed and judged by using the micro-fluidic chip and related sensors, the paper micro-fluidic chip has the characteristics of low cost, simple structure, no need of external drive, flow only depending on self-chromatographic force, rapid flow by adopting blowing pressure and centrifugal force generated by blowing, and faster flow of saliva caused by blowing force of the user, solves many defects of the traditional micro-fluidic chip, and has the characteristics of non-wound rapidness, sensitivity, accuracy, portability, convenience and; the method is simple to operate, a user can directly input saliva and breath samples without professional staff to quickly obtain a diagnosis result, information is uploaded to a mobile phone and a remote monitoring center, and a professional doctor guides health care or treatment, so that the method has substantial significance for timely discovery and treatment of the diseases of the object in the specific place, can be used by people for a long time, is simple, convenient, efficient and low in cost, and is suitable for large-scale popularization and application.

The utility model discloses an among mouth formula oral cavity detection mechanism and corresponding intelligent oral cavity detector technical scheme, each functional module and the modular unit that wherein include all can correspond to specific hardware circuit in the integrated circuit structure, consequently only relate to the improvement of specific hardware circuit, and the hardware part is not only the carrier that belongs to execution control software or computer program, consequently solves corresponding technical problem and obtains corresponding technological effect and also does not relate to the application of any control software or computer program, that is to say, the utility model discloses only utilize the improvement in the aspect of the hardware circuit structure that these modules and units relate to can solve the technical problem that will solve to obtain corresponding technological effect, and need not assist and can realize corresponding function with specific control software or computer program.

In this specification, the invention has been described with reference to specific embodiments thereof. It will, however, be evident that various modifications and changes may be made thereto without departing from the broader spirit and scope of the invention. The specification and drawings are, accordingly, to be regarded in an illustrative rather than a restrictive sense.

Claims

1. A mouth-operated oral cavity detection mechanism is characterized in that the mechanism comprises a hollow blowpipe and a detection chip;

2. The mouth-actuated oral cavity detecting mechanism according to claim 1, wherein said detecting chip is perpendicular to a tube wall of said blow tube, and a horizontal height of an inner wall surface of said blow tube at a position adjacent to said first opening is lowest.

3. The mouth-actuated oral cavity detecting mechanism as claimed in claim 1, wherein the outer surface of said detecting chip is provided with a limiting structure for limiting the length of the first opening of said blowing tube into which said detecting chip is inserted.

4. The mouth-activated oral cavity detecting mechanism of claim 1, wherein the detecting chip is provided with an exhaust hole for exhausting the gas in the detecting cell.

5. The mouth-activated oral cavity detecting mechanism of claim 1,

when the detection chip is used for detecting saliva, the detection chip comprises a cover plate, a filter membrane, a base plate and a bottom plate;

6. The mouth-activated oral cavity detecting mechanism of claim 5, wherein the cover plate, the filter membrane, the base plate and the bottom plate are bonded together by a hot melt adhesive.

7. The mouth-activated oral cavity detecting mechanism of claim 1,

when the detection chip is a dual-function chip for simultaneously detecting saliva and breath, the reaction module comprises a liquid reaction module and a gas reaction module;

8. The mouth-activated oral cavity detecting mechanism of claim 7,

the upper cover plate, the upper substrate, the middle partition plate, the lower substrate and the lower cover plate are bonded through hot melt adhesive.

9. The oral cavity detecting mechanism of any one of claims 1 to 8, wherein the reaction module is composed of a reaction reagent and/or an electrode sheet;

10. A mouth-activated oral cavity detecting mechanism as claimed in any one of claims 1 to 8, wherein the blowing tube is further provided with at least one pre-existing air outlet.

11. A mouth-operated oral cavity detection mechanism is characterized in that the mechanism comprises a hollow blowpipe and a detection chip; a first opening is formed in the pipe wall of the blow pipe, and a through hole is formed in the blow pipe;

12. The mouth-activated oral cavity detecting mechanism of claim 11,

the blowpipe also comprises a first vent hole, a second vent hole is arranged on the detection shell, and the first vent hole is communicated with the second vent hole;

13. The mouth-actuated oral cavity detecting mechanism according to claim 12, wherein the liquid reservoir is disposed in a second cavity of the detecting housing, the second cavity is provided with a liquid inlet hole, the detecting housing is further provided with a liquid inlet channel, one end of the liquid inlet channel is connected to the sample inlet hole, and the other end of the liquid inlet channel faces the liquid inlet hole of the second cavity.

14. The oral cavity of claim 13, wherein the outer side of the detection housing is provided with a conductive insert at a position opposite to the insert of the drainage structure;

15. An intelligent oral cavity detector, which is characterized by comprising a main body, a chip socket, a one-way air outlet valve, a man-machine interaction module, a main control module, a power supply module and a mouth-operated oral cavity detection mechanism as claimed in any one of claims 1 to 14;

16. The intelligent oral monitor of claim 15, wherein the monitor further comprises:

17. The intelligent oral cavity detector according to claim 16, wherein the human body function signal acquisition module comprises a heart rate blood pressure detection unit, an MEMS detection unit and an oral cavity sensor detection unit, and the heart rate blood pressure detection unit, the MEMS detection unit and the oral cavity sensor detection unit are respectively connected to the main control module.

18. The intelligent oral monitor of claim 15, wherein the human-computer interaction module is disposed outside the main body, and the human-computer interaction module comprises:

19. The intelligent oral cavity detector according to claim 15, wherein a box is further provided in the detector, the box is provided inside the main body, and the box is of an openable and closable structure; the chip socket and the mouth-operated oral cavity detection mechanism are arranged in the box body, the box body is provided with a third opening, the blow pipe penetrates through the third opening, and the one-way air outlet valve is arranged in the box body.

20. The intelligent oral cavity detector as claimed in claim 15, wherein the main body is made of flexible material, and the main body is provided with an air permeable mesh, and the air permeable mesh is further provided with a filter material at a position where the air is sucked.