CN114456437A - Polydopamine coating modified antibacterial polyurethane dressing and preparation method and application thereof - Google Patents
Polydopamine coating modified antibacterial polyurethane dressing and preparation method and application thereof Download PDFInfo
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- 239000004814 polyurethane Substances 0.000 title claims abstract description 66
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 63
- 229920001690 polydopamine Polymers 0.000 title claims abstract description 49
- 239000011248 coating agent Substances 0.000 title claims abstract description 45
- 238000000576 coating method Methods 0.000 title claims abstract description 45
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 239000000243 solution Substances 0.000 claims abstract description 51
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 claims abstract description 34
- 239000007983 Tris buffer Substances 0.000 claims abstract description 29
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 claims abstract description 28
- PSBDWGZCVUAZQS-UHFFFAOYSA-N (dimethylsulfonio)acetate Chemical compound C[S+](C)CC([O-])=O PSBDWGZCVUAZQS-UHFFFAOYSA-N 0.000 claims abstract description 19
- CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims abstract description 19
- 229940117986 sulfobetaine Drugs 0.000 claims abstract description 19
- 229960003638 dopamine Drugs 0.000 claims abstract description 17
- 238000002156 mixing Methods 0.000 claims abstract description 15
- 229910000366 copper(II) sulfate Inorganic materials 0.000 claims abstract description 14
- 238000001035 drying Methods 0.000 claims abstract description 12
- 239000000463 material Substances 0.000 claims abstract description 9
- 238000000034 method Methods 0.000 claims description 5
- 230000000845 anti-microbial effect Effects 0.000 claims description 3
- 239000000758 substrate Substances 0.000 claims description 2
- 238000002635 electroconvulsive therapy Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 abstract description 6
- 238000012986 modification Methods 0.000 abstract description 6
- 238000006243 chemical reaction Methods 0.000 abstract description 5
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 abstract description 2
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 abstract 1
- 229960003237 betaine Drugs 0.000 abstract 1
- -1 betaine methacrylate ester Chemical class 0.000 abstract 1
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/36—After-treatment
- C08J9/365—Coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J9/00—Working-up of macromolecular substances to porous or cellular articles or materials; After-treatment thereof
- C08J9/36—After-treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
- A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
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- C08J2375/00—Characterised by the use of polyureas or polyurethanes; Derivatives of such polymers
- C08J2375/04—Polyurethanes
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J2479/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing nitrogen with or without oxygen, or carbon only, not provided for in groups C08J2461/00 - C08J2477/00
- C08J2479/04—Polycondensates having nitrogen-containing heterocyclic rings in the main chain; Polyhydrazides; Polyamide acids or similar polyimide precursors
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Abstract
The invention discloses a polydopamine coating modified antibacterial polyurethane dressing and a preparation method and application thereof, wherein the preparation method comprises the following steps: mixing dopamine, sulfobetaine methacrylate and H2O2And CuSO4Sequentially adding the three components into a Tris solution, and uniformly mixing to obtain a codeposition solution; and immersing the sponge base material in the codeposition solution, oscillating, taking out and drying to constant weight to obtain the polydopamine coating modified antibacterial polyurethane dressing. The invention passes CuSO4/H2O2Initiating dopamine and sulphoneThe betaine methacrylate ester generates codeposition reaction and carries out codeposition modification on the polyurethane sponge, so that the prepared polyurethane dressing shows broad-spectrum, long-acting and stable antibacterial performance.
Description
Technical Field
The invention relates to the technical field of medical materials, in particular to an antibacterial polyurethane dressing modified by a polydopamine coating, and a preparation method and application thereof.
Background
At present, the development of science and technology continuously improves the requirements of people on medical dressings, traditional dressings such as gauze and cotton are easy to breed bacteria, wound exudate and dry dermal tissues are easy to form crusts together to prevent epithelialization, and meanwhile, the wound is easy to adhere to the dressings and can cause secondary trauma to patients when dressing change is uncovered, so that the novel wound dressing is very important.
The foam type polyurethane medical dressing is suitable for a wound granulation formation stage, can absorb redundant wound exudate, can obstruct external foreign matters and partial bacteria, protects exposed nerve endings and relieves pain. Meanwhile, the foam dressing keeps moist, so that dry scab formed by excessive evaporation of wound exudate is avoided, secondary mechanical injury cannot be generated during dressing change, and the wound healing is facilitated. The wound has more bacterial species, common pathogenic bacteria comprise staphylococcus, streptococcus, escherichia coli and the like, and the wound is characterized in that: the same pathogenic bacteria can cause several different pyogenic infections, such as furuncle, carbuncle, abscess, wound infection and the like caused by staphylococcus aureus, and the different pathogenic bacteria can cause the same disease, such as acute cellulitis soft tissue abscess wound infection and the like caused by staphylococcus aureus, streptococcus and escherichia coli, which all show the common characteristics of pyogenic inflammation, namely red, swelling, heat, pain and dysfunction, and have commonality in prevention and treatment. The existing antibacterial dressing is mainly produced by blending an antibacterial agent and raw materials, has an antibacterial effect, but most of the existing antibacterial dressings cannot realize long-acting bacteriostasis, and have narrow antibacterial range and poor effect. It is therefore desirable to provide a new antimicrobial dressing that addresses the above-mentioned problems of the prior art.
Disclosure of Invention
The invention aims to provide an antibacterial polyurethane dressing modified by a polydopamine coating, and a preparation method and application thereof, and aims to solve the problems of short bacteriostatic time-effect, narrow antibacterial range and poor effect of the existing antibacterial dressing.
In order to solve the above technical problem, a first solution provided by the present invention is: antibacterial polyurethane modified by polydopamine coatingThe preparation method of the ester dressing comprises the following steps: mixing dopamine, sulfobetaine methacrylate and H2O2And CuSO4Sequentially adding the three components into a Tris solution, and uniformly mixing to obtain a codeposition solution; and immersing the sponge base material in the codeposition solution, oscillating, taking out and drying to constant weight to obtain the polydopamine coating modified antibacterial polyurethane dressing.
Preferably, the mass fraction of Tris in the Tris solution is 0.5-0.8%, and Tris, dopamine, sulfobetaine methacrylate and H2O2、CuSO4The mass ratio of (A) to (B) is 6: (1-10): (5-50): (1-5): (0.1 to 3).
More preferably, the mass fraction of Tris in the Tris solution is 0.6%.
Preferably, the sponge substrate is an unmodified polyurethane sponge.
Preferably, the specific steps of the shaking treatment are as follows: and (3) oscillating the sponge base material immersed in the codeposition solution in an air oscillator for 5-9 days.
Preferably, the drying temperature is 50-60 ℃.
In order to solve the above technical problem, a second solution provided by the present invention is: the antibacterial polyurethane dressing modified by the polydopamine coating is prepared by the preparation method of the antibacterial polyurethane dressing modified by the polydopamine coating in the first solution. The antibacterial polyurethane dressing modified by the polydopamine coating is applied as a medical dressing.
The invention has the beneficial effects that: different from the condition of the prior art, the invention provides an antibacterial polyurethane dressing modified by a polydopamine coating, and a preparation method and application thereof, wherein CuSO is used for modifying the polydopamine coating4/H2O2The dopamine and the sulfobetaine methacrylate are initiated to generate codeposition reaction, and the polyurethane sponge is subjected to codeposition modification, so that the prepared polyurethane dressing has broad-spectrum, long-acting and stable antibacterial performance.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention.
For the first solution provided by the invention, the preparation method of the polydopamine coating modified antibacterial polyurethane dressing comprises the following steps:
(1) mixing dopamine, sulfobetaine methacrylate and H2O2And CuSO4And sequentially adding the three substances into a Tris solution, and uniformly mixing to obtain a codeposition solution. In the step, the mass fraction of Tris in the Tris solution is 0.5-0.8%, and preferably, the mass fraction of Tris in the Tris solution is 0.6%; tris, dopamine, sulfobetaine methacrylate, H2O2、CuSO4The mass ratio of (A) to (B) is 6: (1-10): (5-50): (1-5): (0.1 to 3).
(2) And immersing the sponge base material in the codeposition solution, oscillating, taking out and drying to constant weight to obtain the polydopamine coating modified antibacterial polyurethane dressing. In the step, the sponge base material is unmodified polyurethane sponge, the sponge base material is immersed in the codeposition solution and is vibrated in an air oscillator for 5-9 days, and the sponge base material is fully modified; and after oscillation, drying in an oven at 50-60 ℃ to constant weight to obtain the poly dopamine coating modified antibacterial polyurethane dressing.
For the second solution provided by the present invention, the antibacterial polyurethane dressing modified by the polydopamine coating is prepared by the preparation method of the antibacterial polyurethane dressing modified by the polydopamine coating in the first solution, so that the antibacterial polyurethane dressings modified by the polydopamine coating in the two solutions are consistent in physical and chemical properties; the antibacterial polyurethane dressing modified by the polydopamine coating is applied as a medical dressing.
Further, the mechanism and advantages of the polydopamine coating modified antibacterial polyurethane dressing of the present invention are elaborated:
1) the invention passes CuSO4/H2O2Initiating the co-deposition reaction of dopamine and sulfobetaine methacrylate to generate polydopamine (PDA for short) and sulfobetaine methacrylate (PSBMA for short), and carrying out the co-deposition modification on the polyurethane sponge. Wherein, the copper ions with proper concentration can promote the polymerization of dopamine and sulfobetaine methacrylate and provide good antibacterial property; the poly sulfobetaine methacrylate generated by the reaction has positive charges and negative charges, can be strongly combined with water molecules through electrostatic induced hydration, shows high resistance to nonspecific protein adsorption, can effectively avoid bacterial adhesion, thereby preventing a biofilm formed by bacteria and showing strong antibacterial performance; the generated polydopamine and the poly sulfobetaine methacrylate have good deposition effect, so that the modified polyurethane surface has long-acting and stable antibacterial performance.
2) Different from the traditional blending, the invention adopts a codeposition method to carry out antibacterial modification on the polyurethane sponge, is a novel antibacterial modification method, and the codeposition solution can be repeatedly used, thereby obviously improving the utilization rate of raw materials.
The polydopamine coating modified antibacterial polyurethane dressing of the present invention is analyzed by the following test through specific examples.
Example 1
In this example, the preparation steps of the antibacterial polyurethane dressing modified by the polydopamine coating are as follows:
(1) adding 500ml water into 3g Tris to prepare Tris solution, and sequentially adding 0.5g dopamine, 3g sulfobetaine methacrylate and 0.5ml H2O2And 0.3g of CuSO4And uniformly mixing to obtain a codeposition solution.
(2) And (3) placing a piece of common polyurethane sponge with the thickness of 5cm by 0.5cm into the codeposition solution, oscillating for 5 days in an air oscillator, taking out, and drying in an oven at 50 ℃ to constant weight to obtain the polydopamine coating modified antibacterial polyurethane dressing.
Example 2
In this example, the preparation steps of the antibacterial polyurethane dressing modified by the polydopamine coating are as follows:
(1) adding 500ml water into 3g Tris to prepare Tris solution, and sequentially adding 2g dopamine, 25g sulfobetaine methacrylate and 0.5ml H2O2And 1.5g of CuSO4And uniformly mixing to obtain a codeposition solution.
(2) And (3) placing a piece of common polyurethane sponge with the thickness of 5cm by 0.5cm into the codeposition solution, oscillating for 5 days in an air oscillator, taking out, and drying in an oven at 50 ℃ to constant weight to obtain the polydopamine coating modified antibacterial polyurethane dressing.
Example 3
In this example, the preparation steps of the antibacterial polyurethane dressing modified by the polydopamine coating are as follows:
(1) adding 500ml water into 3g Tris to prepare Tris solution, and sequentially adding 0.5g dopamine, 25g sulfobetaine methacrylate and 1ml H2O2And 1g of CuSO4And uniformly mixing to obtain a codeposition solution.
(2) And (3) placing a piece of common polyurethane sponge with the thickness of 5cm by 0.5cm into the codeposition solution, oscillating for 5 days in an air oscillator, taking out, and drying in an oven at 50 ℃ to constant weight to obtain the polydopamine coating modified antibacterial polyurethane dressing.
Example 4
In this example, the preparation steps of the antibacterial polyurethane dressing modified by the polydopamine coating are as follows:
(1) adding 500ml water into 3g Tris to prepare Tris solution, and sequentially adding 1g dopamine, 15g sulfobetaine methacrylate and 1ml H2O2And 0.6g of CuSO4And uniformly mixing to obtain a codeposition solution.
(2) And (3) placing a piece of common polyurethane sponge with the thickness of 5cm by 0.5cm into the codeposition solution, oscillating for 5 days in an air oscillator, taking out, and drying in an oven at 50 ℃ to constant weight to obtain the polydopamine coating modified antibacterial polyurethane dressing.
Example 5
In this example, the preparation steps of the antibacterial polyurethane dressing modified by the polydopamine coating are as follows:
(1) adding 500ml water into 3g Tris to prepare Tris solution, and sequentially adding 1g dopamine, 15g sulfobetaine methacrylate and 1ml H2O2And 0.625g CuSO4And uniformly mixing to obtain a codeposition solution.
(2) And (3) placing a piece of common polyurethane sponge with the thickness of 5cm by 0.5cm into the codeposition solution, oscillating the common polyurethane sponge in an air oscillator for 10 days, taking out the common polyurethane sponge, and drying the common polyurethane sponge in an oven at 50 ℃ to constant weight to obtain the polydopamine coating modified antibacterial polyurethane dressing.
Comparative example 1
In this comparative example, an unmodified, commonly commercially available polyurethane sponge dressing (cefazepril) was selected.
Test 1 cytotoxicity test
The polydopamine coating modified antibacterial polyurethane dressing prepared in the above examples 1 to 5 is subjected to cytotoxicity test, and the specific test steps are as follows: firstly, extracting a sample leaching solution, immersing a sterilized sample into 1mL of DMEM medium, and keeping the sample at 37 ℃ for 24 hours; then, the medium was sterilized by filtration using a sterile filter (pore size: 0.22 μm); subsequently, fibroblasts were seeded into each well of a 96-well plate and incubated at 37 ℃ for 24 hours; then replacing the culture medium with 500. mu.L of the leaching solution or the original culture medium containing 10% fetal calf serum; after 24 hours, the medium was changed to 100 μ L of the original medium containing 10 μ L of CCK8 solution, followed by incubation at 37 ℃ for 2 hours; finally, the OD value at a wavelength of 450nm was measured using a microplate reader, and the cell survival rate was calculated. The test results are shown in table 1, and it can be seen that the cell survival rate is maintained at more than 85% under the action of the dressings prepared in examples 1 to 5, which proves that the dressing can be applied as a medical dressing.
TABLE 1 cytotoxicity assays
| Example 1 | Example 2 | Example 3 | Example 4 | Example 5 | |
| Cell viability/% | 86％ | 89％ | 92％ | 91％ | 89％ |
Test 2 antimicrobial Property test
The antibacterial test is performed on the polydopamine coating modified antibacterial polyurethane dressing prepared in the above examples 1-5, and the antibacterial test adopts gram-negative bacteria (escherichia coli) and gram-positive bacteria (staphylococcus aureus) to evaluate model biological dirt of the antibacterial performance of the membrane, and the test steps are as follows: first, a membrane sample (1cm × 1cm) was placed in a petri dish and sterilized with ultraviolet light for 30 minutes; then, 300. mu.l of cell concentration 2X 10 was added to the membrane surface6CFU/ml bacterial solution, and at 37 degrees C were incubated for 24 hours. After incubation, the bacteria were removed from the membrane surface and transferred to 50 ml PBS solution (pH 7.4); then, the bacterial solution was spread on an agar plate and cultured at 37 ℃ for another 24 hours; finally, bacterial colonies were counted and the antibacterial rate was calculated. In the test process, the bacterial inhibition rates of the strains after 24h, 48h and 72h are respectively recorded and calculated, and the results are shown in Table 2It can be seen that, under the action of the dressings prepared in examples 1-5, even after 72 hours, the bacteriostasis rate of the prepared dressings to the tested strains can be maintained above 80%, while the bacteriostasis rate of comparative example 1 is obviously reduced and is far lower than the bacteriostasis level of examples 1-5, so that the prepared dressings are proved to have long-acting and stable antibacterial capability.
TABLE 2 antibacterial Properties test
Different from the condition of the prior art, the invention provides an antibacterial polyurethane dressing modified by a polydopamine coating, and a preparation method and application thereof, wherein CuSO is used for modifying the polydopamine coating4/H2O2The dopamine and the sulfobetaine methacrylate are initiated to generate codeposition reaction, and the polyurethane sponge is subjected to codeposition modification, so that the prepared polyurethane dressing has broad-spectrum, long-acting and stable antibacterial performance.
It should be noted that the above embodiments belong to the same inventive concept, and the description of each embodiment has a different emphasis, and reference may be made to the description in other embodiments where the description in individual embodiments is not detailed.
The above-mentioned embodiments only express the embodiments of the present invention, and the description thereof is more specific and detailed, but not construed as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (8)
1. A preparation method of an antibacterial polyurethane dressing modified by a polydopamine coating is characterized by comprising the following steps:
mixing dopamine, sulfobetaine methacrylate and H2O2And CuSO4Sequentially adding the three components into a Tris solution, and uniformly mixing to obtain a codeposition solution;
and immersing the sponge base material in the codeposition solution, vibrating, taking out and drying to constant weight to obtain the polydopamine coating modified antibacterial polyurethane dressing.
2. The method for preparing the polydopamine coating modified antibacterial polyurethane dressing according to claim 1, wherein the mass fraction of Tris in the Tris solution is 0.5-0.8%, and the Tris, dopamine, sulfobetaine methacrylate and H are2O2、CuSO4The mass ratio of (A) to (B) is 6: (1-10): (5-50): (1-5): (0.1 to 3).
3. The method for preparing the polydopamine coating modified antibacterial polyurethane dressing of claim 2, wherein the mass fraction of Tris in the Tris solution is 0.6%.
4. The method for preparing the polydopamine coating modified antibacterial polyurethane dressing according to claim 1, wherein the sponge substrate is unmodified polyurethane sponge.
5. The preparation method of the polydopamine coating modified antibacterial polyurethane dressing according to claim 1, wherein the shock treatment comprises the following specific steps: and oscillating the sponge base material immersed in the codeposition solution in an air oscillator for 5-9 days.
6. The preparation method of the polydopamine coating modified antibacterial polyurethane dressing according to claim 1, wherein the drying temperature is 50-60 ℃.
7. The antibacterial polyurethane dressing modified by the polydopamine coating is characterized by being prepared by the preparation method of the antibacterial polyurethane dressing modified by the polydopamine coating according to any one of claims 1-7.
8. Use of the polydopamine coating modified antimicrobial polyurethane dressing as claimed in claim 7 as a medical dressing.
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| CN104194023A (en) * | 2014-08-12 | 2014-12-10 | 东南大学 | Dopamine-based method for improving surface hydrophilicity and biocompatibility of medical polyurethane material |
| CN107987578A (en) * | 2017-12-08 | 2018-05-04 | 山东交通学院 | A kind of preparation method of the surface coating products with antifouling sterilizing function |
| CN109912826A (en) * | 2019-03-25 | 2019-06-21 | 中国科学院兰州化学物理研究所 | A kind of surface modification has the biomaterial and preparation method thereof of hydrophilic lubrication coating |
| CN112717207A (en) * | 2020-12-15 | 2021-04-30 | 山东大学 | Long-acting antibacterial multifunctional coating based on bionic dopamine and preparation method and application thereof |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104194023A (en) * | 2014-08-12 | 2014-12-10 | 东南大学 | Dopamine-based method for improving surface hydrophilicity and biocompatibility of medical polyurethane material |
| CN107987578A (en) * | 2017-12-08 | 2018-05-04 | 山东交通学院 | A kind of preparation method of the surface coating products with antifouling sterilizing function |
| CN109912826A (en) * | 2019-03-25 | 2019-06-21 | 中国科学院兰州化学物理研究所 | A kind of surface modification has the biomaterial and preparation method thereof of hydrophilic lubrication coating |
| CN112717207A (en) * | 2020-12-15 | 2021-04-30 | 山东大学 | Long-acting antibacterial multifunctional coating based on bionic dopamine and preparation method and application thereof |
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