CN114452533A - Neural stimulator and neural stimulation system - Google Patents
Neural stimulator and neural stimulation system Download PDFInfo
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- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
- A61N1/36128—Control systems
- A61N1/36135—Control systems using physiological parameters
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Abstract
The application provides a neurostimulator and neurostimulation system, neurostimulator sets up in the patient is internal, neurostimulator includes: an electrode module comprising a plurality of acquisition contacts, each acquisition contact for sensing and outputting an electrical signal of the patient; a control module for receiving the electrical signal and outputting a selection signal; the selection module is used for selecting at least two of the plurality of acquisition contacts according to the selection signal so as to enable the selected acquisition contacts to be conducted with the control module. This application makes different collection contacts can both input the selection module through the circuit through setting up the selection module, and can both be selected alone, and the circuit between selection module and the control module can multiplex, and the control module's that needs is small in port quantity in the signal of telecommunication is gathered.
Description
Technical Field
The present application relates to the field of implantable medical devices, and more particularly, to a neurostimulator and a neurostimulation system.
Background
In the implantable medical device, the nerve stimulator can effectively control the symptoms of functional diseases and mental diseases by releasing stimulation signals to a patient.
However, in the prior art, the housing of the nerve stimulator is generally used as a fixed acquisition reference point, and after the nerve stimulator is implanted into a human body, the acquisition contact cannot move randomly. The controller needs a plurality of interfaces to connect each acquisition contact, and the number of lines between a plurality of ports of the controller and the acquisition contacts is large, so that faults are easy to occur.
Disclosure of Invention
An object of this application is to provide neural stimulator and neural stimulation system, and neural stimulator makes the collection contact of difference input to selection module and can both be selected alone through setting up selection module, has solved the problem that needs occupy too many control module ports in neural stimulator's the signal of telecommunication collection process.
The purpose of the application is realized by adopting the following technical scheme:
the present application provides a neurostimulator, the neurostimulator sets up in the patient, neurostimulator includes: an electrode module comprising a plurality of acquisition contacts, each acquisition contact for sensing and outputting an electrical signal of the patient; a control module for receiving the electrical signal and outputting a selection signal; the selection module is used for selecting at least two of the plurality of acquisition contacts according to the selection signal so as to enable the selected acquisition contacts to be conducted with the control module.
The technical scheme has the beneficial effects that: through the selection signal of the control module, different acquisition contacts can be selected, different forms of calculation such as difference can be carried out on a plurality of electric signals of different acquisition contacts, the calculation of the plurality of electric signals of the selected acquisition contacts is favorable for reducing the interference of noise signals, and useful signals are extracted. Multiple groups of different acquisition contacts can be selected for multiple calculations to obtain accurate physiological states of the patient near the different acquisition contacts.
From this, neural stimulator makes the different collection contacts can both be inputed to the selection module through the circuit through setting up the selection module, and can both be selected alone, and the circuit between selection module and the control module can multiplex, and required and the control module's that occupies port is small in quantity, has reduced neural stimulator's trouble number of times, has reduced the maintenance cost from this, has prolonged neural stimulator's life.
In some optional embodiments, the electrode module comprises at least one electrode lead, each of the electrode leads comprising a plurality of acquisition contacts for sensing the electrical signal; the selection module comprises selection units which are not less than the number of the electrode leads, and each selection unit is used for selecting one of the acquisition contacts according to a selection signal of the controller so as to enable the selected acquisition contact to be conducted with the control module.
The technical scheme has the beneficial effects that: the selection unit is used for connecting the acquisition contact of the electrode lead with the control module, so that the volume and the weight of the control module are reduced, the cost of the control module is saved, and the popularization in the nerve stimulator is facilitated. When the number of the selection units is more than 1, the number of lines and ports required by each selection unit of the selection module is small; for electronic components requiring more ports, the cost of the electronic components increases sharply with the number of the ports, for example, a 32-port chip is several times the price of a 16-port chip, and therefore, the cost of a single selection unit can be greatly reduced by adopting a plurality of selection units without affecting the overall performance of the selection module.
In addition, when some selection units are in fault, other selection units are not affected, and the stability of the overall structure of the nerve stimulator is improved. The nerve stimulator is implanted in a patient and is essential for relieving the pain of the patient, especially for partial addicts, depression patients or manic patients, if the selection module is provided with only one selection unit, when the selection unit fails, the whole nerve stimulator cannot work normally, and the patient can make irrational behaviors because the patient cannot be treated, such as relapse of the addicts, self-disability or even suicide of the depression patients, injury of the manic patients and the like.
In some optional embodiments, the selection unit comprises a control terminal, a plurality of input terminals, and an output terminal; each input end of the selection unit is electrically connected with one acquisition contact of the electrode lead respectively; the control end of the selection unit is electrically connected with the control module to obtain the selection signal; and the output end of the selection unit selects one of the plurality of acquisition contacts of the electrode lead according to the selection signal so as to enable the selected acquisition contact to be conducted with the control module.
The technical scheme has the beneficial effects that: the control end of the selection unit receives the selection signal, so that the selected acquisition contact is conducted with the control module, and a doctor can select the electric signal of any acquisition contact.
In some optional embodiments, the control module is further configured to control at least one of the electrode leads to electrically stimulate tissue of the patient.
The technical scheme has the beneficial effects that: the electrode lead can also realize the electrical stimulation to the tissue of the patient, and the electrical signal is collected under the condition, so that the collected data is more accurate.
In some optional embodiments, the control module includes an acquisition control unit for outputting the selection signal and a stimulation control unit for controlling the electrode leads to electrically stimulate the tissue of the patient.
The technical scheme has the beneficial effects that: the signal acquisition and stimulation release functions are distinguished through the acquisition control unit and the stimulation control unit and are respectively used for the acquisition and stimulation functions of the nerve stimulator, and the intelligent degree is higher.
In some optional embodiments, the control module further includes a signal amplifying unit, the signal amplifying unit is disposed between the electrode module and the collecting control unit, and the signal amplifying unit is configured to amplify the electrical signal collected by the selected collecting contact.
The technical scheme has the beneficial effects that: through the amplification of the signal amplification unit to the signal of telecommunication, the voltage range after the amplification can be fit for more follow-up circuit processing, has more follow-up circuits can be selected to realize more combinations on the circuit structure, is favorable to improving the precision that the neural stimulator was gathered to the signal of telecommunication.
In some optional embodiments, the control module further includes a filtering unit, the filtering unit is disposed between the amplifying unit and the collecting control unit, and the filtering unit is configured to filter an interference signal in the electrical signal of the selected collecting contact.
The technical scheme has the beneficial effects that: through setting up the filtering unit, can realize interfering signal's filtering among the signal of telecommunication, improve the quality of the signal of telecommunication of gathering, and then guarantee that control module has higher SNR when handling the signal of telecommunication.
In some optional embodiments, the control module further includes an analog-to-digital conversion unit, and the analog-to-digital conversion unit is configured to perform analog-to-digital conversion on the electrical signal of the selected acquisition contact to convert the electrical signal into electroencephalogram data.
The technical scheme has the beneficial effects that: the electric signal of the selected acquisition contact is converted into a digital signal which can be stored and operated by a program through the high-speed sampling of the analog-to-digital conversion unit. The digital signal converted by the analog-to-digital conversion unit is more beneficial to subsequent comparison compared with the electric signal.
In some optional embodiments, the neurostimulator further comprises a wireless communication module, the controller is further used for establishing wireless communication connection with the external programmer through the wireless communication module, and the controller is further used for outputting electroencephalogram acquisition data; the external program controller is used for receiving the electroencephalogram acquisition data.
The technical scheme has the beneficial effects that: can establish neural stimulator and external programme-controlled wireless connection through wireless communication module, need set up communication line between neural stimulator and the external controller for wired connection, can reduce the rejection that the patient was implanted to communication line, improve patient's use and experience.
The present application further provides a neurostimulation system comprising the neurostimulator of any of the above.
The technical scheme has the beneficial effects that: the neurostimulation system can more accurately acquire the real-time state of the brain treatment area of the patient, so that a doctor can make a more effective electrostimulation treatment scheme for the patient.
In some alternative embodiments, the electrode module includes at least one electrode lead, and the control module is further configured to control the at least one electrode lead to electrically stimulate tissue of the patient.
The technical scheme has the beneficial effects that: the doctor can acquire the electric signals through the acquisition contact of the electrode lead in a targeted manner according to the treatment needs of the patient, so that a better auxiliary treatment effect is achieved for the patient; the electrical signals can be acquired through at least one electrode lead under the condition that the brain region can be electrically stimulated, and the acquired data are more accurate.
Drawings
The present application is further described below with reference to the drawings and examples.
Fig. 1 is a schematic structural diagram of a neurostimulator provided by an embodiment of the present application;
FIG. 2 is a schematic structural diagram of another neurostimulator provided by embodiments of the present application;
FIG. 3 is a schematic structural diagram of an electrode lead according to an embodiment of the present disclosure;
FIG. 4 is a schematic structural diagram of another electrode lead provided in the embodiments of the present application;
FIG. 5 is a schematic structural diagram of a selecting unit provided in an embodiment of the present application;
FIG. 6 is a schematic structural diagram of a control module provided in an embodiment of the present application;
FIG. 7 is a schematic structural diagram of another control module provided in an embodiment of the present application;
FIG. 8 is a schematic structural diagram of another control module provided in the embodiments of the present application;
FIG. 9 is a schematic structural diagram of yet another neurostimulator provided by embodiments of the present application;
fig. 10 is a schematic structural diagram of a neurostimulation system provided by an embodiment of the application.
In the figure: 10. a neurostimulation system; 100. a nerve stimulator; 110. a control module; 111. an acquisition control unit; 112. a stimulation control unit; 113. an amplifying unit; 114. a filtering unit; 115. an analog-to-digital conversion unit; 120. a selection module; 121. a selection unit; 130. an electrode module; 131. an electrode lead; 140. a wireless communication module; 200. an external program controller.
Detailed Description
In order to make the technical solutions better understood by those skilled in the art, the technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only partial embodiments of the present application, but not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Referring to fig. 1 and 2, an embodiment of the present application provides a neurostimulator 100, wherein the neurostimulator 100 is arranged in a patient, and the neurostimulator 100 comprises an electrode module 130, a control module 110 and a selection module 120.
The electrode module 130 includes a plurality of acquisition contacts, each of which is used to sense and output an electrical signal of the patient. Herein, the electrical signal refers to a bioelectric signal since the neurostimulator is implanted in the patient. The electrical signal may be at least one of a cortical electrical signal (Ecog), a Local Field Potential (LFP) signal, an action potential (Spike) signal of the patient's brain. The collecting contact may be at least one of a micro-electrode or a macro-electrode disposed on the electrode module 130.
The electrode module 130 can be a stimulation electrode which is used for being implanted into a human body and can collect an electric signal, which is disclosed in chinese patent CN 113599695A; the electrode module 130 can also be a nerve electrical signal collecting and functional electrical stimulation electrode implanted in human tissue as disclosed in chinese patent CN 110975136A. The present application is not limited thereto.
The control module 110 is configured to receive the electrical signal and output a selection signal. The control module 110 may include a memory unit and a processor unit, and the size, shape and location of the control module 110 are not limited herein. The control functions of the control module 110 may be implemented by an MPU, MCU, DSP, FPGA, or any combination thereof. The control module 110 may be a module including an electrical stimulation circuit applied to brain stimulation as disclosed in chinese patent CN111346297A, or including an acquisition circuit applied to DBS as disclosed in chinese patent CN111323637A, which is not limited in this application.
The selection module 120 is configured to select at least two of the plurality of acquisition contacts according to the selection signal, so that the selected acquisition contacts are conducted with the control module 110. The selection module 120 may include an existing data selector, through which one or more specific signals among the plurality of input signals are output.
Through the selection signal of the control module 110, different acquisition contacts can be selected, different forms of calculation such as difference can be performed on a plurality of electric signals of different acquisition contacts, the calculation of the plurality of electric signals of the selected acquisition contacts is helpful for reducing the interference of noise signals, and useful signals are extracted. Multiple groups of different acquisition contacts can be selected for multiple calculations to obtain accurate physiological states of the patient near the different acquisition contacts.
Therefore, the selection signal of the control module 110 acts on the selection module 120, so that different acquisition contacts of the electrode module 130 can be selected, and the electric signal obtained from the selection contacts is more reasonable. And obtaining data results of different electric signals so that a doctor can know and compare the real-time situation of the brain area of the patient, and the electric stimulation treatment scheme made by the doctor for the patient is more effective. The neural stimulator 100 is provided with the selection module 120, so that different acquisition contacts can be input into the selection module 120 through lines and can be selected independently, the lines between the selection module 120 and the control module 110 can be multiplexed, the number of required ports of the control module 100 is small, the number of times of faults of the neural stimulator 100 is reduced, the maintenance cost is reduced, and the service life of the neural stimulator 100 is prolonged.
In some embodiments, the electrode module 130 may include at least one electrode lead 131, each of the electrode leads 131 including a plurality of collecting contacts for sensing the electrical signal. The selection module 120 includes no less than the number of the electrode wires 131 of the selection units 121, and each of the selection units 121 is configured to select one of the plurality of acquisition contacts according to a selection signal of the controller so as to make the selected acquisition contact and the control module 110 conductive.
Referring to fig. 3, in one particular application, a physician uses neurostimulator 100 to treat a patient for an addictive disorder. The doctor implants an electrode lead 131 in a deep brain region of an inner sac forelimb of a patient, and twelve acquisition contacts are arranged on the electrode lead 131 and used for sensing a plurality of electric signals near the inner sac forelimb. The neurostimulator 100 is provided with two selection units 121, the two selection units 121 may select at least two of the plurality of acquisition contacts according to the selection signal of the control module 110, for example, the acquisition contact (i) and the acquisition contact (c), or the acquisition contact (c) and the acquisition contact (r) may be selected, so that the selected acquisition contact is conducted with the control module 110, and the selected acquisition contact may transmit the acquired electrical signal to the control module 110. In this particular application, only two ports of the control module need be used to receive the electrical signal of the selection module.
Referring to fig. 4, in another specific application, a physician implants a first electrode lead 131 in the area of the patient's left inner capsular forelimb, the first electrode lead 131 including a collection contact (r) to
Implanting a second electrode lead 131 in the right inner capsule forelimb region of the patient, the second electrode lead 131 including a collection contact
To
The acquisition contacts are used to sense a plurality of electrical signals near the inner bladder forelimb. The neurostimulator 100 is provided with four selection units 121, and each electrode lead 131 corresponds to two selectionsThe cell 121 is selected. At least two of the plurality of collecting contacts can be selected according to the selection signal of the control module 110, for example, the collecting contact (r) and the collecting contact (c), or the collecting contact (r) and the collecting contact (c) can be selected
So that the selected collection contact is conducted with the control module 110, not only can the collection of the single-side electric signals be realized, but also the electric signals of the collection contacts of the left and right brains can be collected selectively at the same time. In this specific application, only four ports of the control module need to be used for receiving the electrical signals of the selection module.
In addition, the individual electrode leads 131 shown in fig. 3 and 4 each include 12 collection contacts, and in some other examples, the number of collection contacts may be different. In addition, while the collection contacts shown in fig. 3 and 4 are shown as being arranged in-line on the electrode wire 131, in some other examples, the collection contacts may be arranged in a ring, alternating arrangement, or any other desired arrangement on the electrode wire 131. In addition, the electrode lead 131 may also be configured in any other shape, such as a spiral shape, a ring shape, or the like. The collecting contacts may also be in the form of electrode pads or the like, for example in the form of a split electrode as disclosed in chinese patent CN 112604159A.
The electric signals can be acquired through the acquisition contact of the electrode lead 131 in a targeted manner according to the treatment requirements of doctors on patients, so that a better auxiliary treatment effect is achieved on the patients.
Because the number of the ports of the control module 110 is limited, the control module 110 with multiple ports is selected, on one hand, the size and the weight of the control module are increased, bad application experience is brought to a patient, and on the other hand, the control module with multiple ports is high in cost and is not beneficial to popularization and application of the neurostimulator.
Therefore, the selection unit is used for conducting the acquisition contact of the electrode lead and the control module 110, so that the volume and the weight of the control module 110 can be reduced, the cost of the control module 110 is saved, and the popularization in the nerve stimulator is facilitated. The selection unit 121 is used for connecting the acquisition contact of the electrode lead with the control module 110, so that the volume and the weight of the control module 110 are reduced, the cost of the control module 110 is saved, and the popularization of the nerve stimulator is facilitated. When the number of the selection units 121 is greater than 1, the number of lines and ports required and occupied by each selection unit 121 of the selection module 120 is small; for electronic components requiring more ports, the cost increases sharply as the number of ports increases, for example, a 32-port chip is several times the price of a 16-port chip, and therefore, the cost of a single selection unit 121 can be greatly reduced by using a plurality of selection units 121 without affecting the overall performance of the selection module 120.
In addition, when some of the selection units 121 fail, other selection units 120 are not affected, and the stability of the overall structure of the neurostimulator 100 is improved. The neurostimulator 100 is implanted in a patient and is necessary for relieving the pain of the patient, especially for partial addicts, depressed patients or manic patients, if the selection module 120 is provided with only one selection unit 121, when the selection unit 121 fails, the whole neurostimulator 100 cannot work normally, and the patient may take irrational behaviors due to no treatment, such as relapse of the addicts, self-disability or even suicide of the depressed patients, injury of the manic patients to others, and the like.
Referring to fig. 5, in some embodiments, the selection unit 121 may include a control terminal, a plurality of input terminals, and an output terminal. Each input terminal of the selection unit 121 is electrically connected to one of the collection contacts of the electrode wires 131. The control end of the selection unit 121 is electrically connected to the control module 110 to obtain the selection signal. The output end of the selection unit 121 selects one of the plurality of collecting contacts of the electrode wire 131 according to the selection signal, so that the selected collecting contact is conducted with the control module 110.
The control module 110 may be connected to the control terminal of the selection unit 121 by an I2C (Inter-Integrated Circuit) bus. The I2C bus is a two-wire or four-wire serial bus, the I2C bus can realize master-slave communication only by at least one data wire and one clock wire, and the bus interface is integrated in the chip without special interface circuit. Therefore, the I2C bus simplifies the wiring of a hardware circuit PCB, reduces the system cost and improves the system reliability. The I2C bus can be easily standardized and modular for easy reuse by users. In addition, under the condition that additional hardware is not needed, master-slave communication between the control module 110 and the plurality of selection units 121 can be realized through the I2C bus, so that the number of the control module 110 ports and the selection units 121 ports is reduced, and the cost is further saved.
Therefore, the control end of the selection unit 121 receives the selection signal, so that the selected acquisition contact is conducted with the control module 110, and the doctor can select the electric signal of any acquisition contact.
Referring to fig. 6, in some embodiments, the control module 110 may also be configured to control at least one of the electrode leads 131 to electrically stimulate the patient's tissue. The electrode leads 131 may be provided with a plurality of stimulation contacts that electrically stimulate the patient's tissue. The tissue of the patient may be a brain tissue, a spinal nerve tissue, or other human tissue of the patient.
In one particular application, one or more of the contacts of the electrode lead 131 may serve as both acquisition and stimulation contacts, e.g., acquisition and stimulation of one contact may be performed in a time-shared manner, with acquisition occurring first and stimulation occurring thereafter, and then repeated one or more times. In another specific application, some of the contacts may act as acquisition contacts for acquiring electrical signals of the brain region with which they are in contact; while other contacts may act as stimulation contacts for applying electrical stimulation signals to the brain region with which they are in contact. Wherein the collection contacts and stimulation contacts may be arranged in pairs or groups, each stimulation contact corresponding to at least one collection contact.
Thus, the electrode lead 131 also allows for electrical stimulation of the patient's tissue, in which case electrical signals are collected, and the collected data is more accurate.
Specifically, the control module 110 may include an acquisition control unit 111 and a stimulation control unit 112, where the acquisition control unit 111 is configured to output the selection signal, and the stimulation control unit 112 is configured to control the electrode lead 131 to electrically stimulate the tissue of the patient.
Therefore, the acquisition control unit 111 and the stimulation control unit 112 distinguish the signal acquisition function from the stimulation release function, and are respectively used for the acquisition and stimulation functions of the neurostimulator 100, so that the degree of intelligence is high.
Referring to fig. 7, specifically, the control module 110 may further include a signal amplifying unit 113, where the signal amplifying unit 113 is disposed between the electrode module 130 and the collecting control unit 111, and the signal amplifying unit 113 is configured to amplify the electrical signal collected by the selected collecting contact.
The signal amplification unit 113 may have a variable amplification gain or a fixed amplification gain to amplify an electric signal having a small amplitude (for example, a level of 5 μ V to 100 μ V). Because the frequency of the electric signal is concentrated in 0.5 Hz-100 Hz, the amplitude is only 5 muV-100 muV, the electric signal is a very weak biological signal, and the selection surface of a subsequent processing circuit is narrow. Therefore, by amplifying the electrical signal through the signal amplifying unit 113, the amplified voltage range can be suitable for more subsequent circuit processing, and more subsequent circuits can be selected, so that more combinations on the circuit structure can be realized, and the improvement of the accuracy of the electrical signal acquisition by the neural stimulator 100 is facilitated. The subsequent circuits may be signal isolation, signal amplification, signal filtering, sample/hold circuit, signal analog-to-digital conversion circuit, etc.
Specifically, the control module 110 may further include a filtering unit 114, where the filtering unit 114 is disposed between the amplifying unit 113 and the collecting control unit 111, and the filtering unit 114 is configured to filter an interference signal in the electrical signal of the selected collecting contact. Referring to fig. 8, in some embodiments, the filtering unit 114 may be disposed between the signal amplifying unit 113 and the acquisition control unit 111, and the degree of distinction between the electrical signal amplified by the signal amplifying unit 113 and the interference signal is higher, so that the filtering unit 114 has a better effect of filtering the interference signal. The interference signal may be power frequency interference, radiation noise, power noise, etc.
Therefore, by arranging the filtering unit 114, the interference signals in the electrical signals can be filtered, the quality of the collected electrical signals is improved, and the control module 110 is ensured to have a higher signal-to-noise ratio when processing the electrical signals.
Referring to fig. 9, specifically, the control module 110 may further include an analog-to-digital conversion unit 115, where the analog-to-digital conversion unit 115 is configured to perform analog-to-digital conversion on the electrical signal of the selected acquisition contact to convert the electrical signal into electroencephalogram data. The electrical signal is an analog signal, and the electrical signal of the selected acquisition contact is sampled at a high speed by the analog-to-digital conversion unit 115 and converted into a digital signal which can be stored and operated by a program. Thus, the digital signal converted by the analog-to-digital conversion unit 115 is more advantageous for subsequent comparison than the electric signal.
Referring to fig. 10, in some embodiments, the neurostimulator 100 may further comprise a wireless communication module 140, the controller is further configured to establish a wireless communication connection with the external programmer 200 through the wireless communication module 140, and the controller is further configured to output electroencephalogram acquisition data; the external program controller 200 is used for receiving the electroencephalogram acquisition data.
Wherein, the wireless communication module 140 may include one or more of a 4G communication unit, a 5G communication unit, a WIFI communication unit, a near field communication unit, a WiGig communication unit, a bluetooth communication unit, a ZigBee communication unit, a microwave communication unit, a satellite communication unit, and an atmospheric laser communication unit. Compared with wired communication, the wireless communication module 140 has longer communication distance, is not limited by wires, has certain mobility, can communicate through wireless connection in a mobile state, and has lower cost.
Therefore, wireless connection between the nerve stimulator 100 and external program control can be established through the wireless communication module 140, and compared with the wired connection that a communication line needs to be arranged between the nerve stimulator 100 and an external controller, rejection of a patient to the implantation of the communication line can be reduced, and the use experience of the patient is improved.
Referring to fig. 10, the present application further provides a neurostimulation system 10 including the neurostimulator 100 of any of the above.
The neurostimulator 100 is used in the neurostimulation system 10, and different acquisition contacts can be selected through the selection signal of the control module 110 of the neurostimulator 100, so as to obtain data results of different electric signals, thereby facilitating comparison and knowing the real-time condition of the brain region of the patient by a doctor. Thus, neurostimulation system 10 can more accurately obtain the real-time status of the treatment area of the brain of the patient, so that the physician can formulate a more effective electrical stimulation treatment plan for the patient.
In some embodiments, the electrode module 130 includes at least one electrode lead 131, and the control module 110 is further configured to control the at least one electrode lead 131 to electrically stimulate the tissue of the patient.
Therefore, a doctor can acquire the electric signals through the acquisition contact of the electrode lead 131 in a targeted manner according to the treatment needs of the patient, so that a better auxiliary treatment effect is achieved for the patient; the electrical signals are collected through the at least one electrode wire 131 under the condition that the brain region can be electrically stimulated, and the collected data are more accurate.
It should be noted that the terms "first," "second," and the like in the description and claims of the present application and in the above-described drawings are configured to distinguish similar objects and are not necessarily configured to describe a particular order or sequence. It is to be understood that the data so used is interchangeable under appropriate circumstances such that the embodiments of the application described herein are capable of operation in sequences other than those illustrated or described herein. Furthermore, the terms "comprises," "comprising," and "having," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, article, or apparatus that comprises a list of steps or elements is not necessarily limited to those steps or elements expressly listed, but may include other steps or elements not expressly listed or inherent to such process, method, article, or apparatus.
When an element is referred to as being "on" or "on," "connected to" or "coupled to" another element, it can be directly on, connected or coupled to the other element or intervening elements may be present. However, when an element is referred to as being "directly on," "directly connected to" or "directly coupled to" another element, there are no intervening elements present. For purposes of this disclosure, the term "connected" may refer to physically, electrically, etc., and may or may not have intermediate components.
While the present application is described in terms of various aspects, including exemplary embodiments, the principles of the invention should not be limited to the disclosed embodiments, but are also intended to cover various modifications, equivalents, and alternatives falling within the spirit and scope of the invention as defined by the appended claims.
Claims (11)
1. A neurostimulator disposed in a patient, the neurostimulator comprising:
an electrode module comprising a plurality of acquisition contacts, each acquisition contact for sensing and outputting an electrical signal of the patient;
a control module for receiving the electrical signal and outputting a selection signal;
the selection module is used for selecting at least two of the plurality of acquisition contacts according to the selection signal so as to enable the selected acquisition contacts to be conducted with the control module.
2. The neurostimulator of claim 1, wherein the electrode module comprises at least one electrode lead, each of the electrode leads comprising a plurality of acquisition contacts for sensing the electrical signal;
the selection module comprises selection units which are not less than the number of the electrode leads, and each selection unit is used for selecting one of the plurality of acquisition contacts according to a selection signal of the controller so as to enable the selected acquisition contact to be conducted with the control module.
3. The neurostimulator according to claim 2, wherein the selection unit comprises a control terminal, a plurality of input terminals and an output terminal;
each input end of the selection unit is electrically connected with one acquisition contact of the electrode lead respectively;
the control end of the selection unit is electrically connected with the control module to obtain the selection signal;
and the output end of the selection unit selects one of the plurality of acquisition contacts of the electrode lead according to the selection signal so as to enable the selected acquisition contact to be conducted with the control module.
4. The neurostimulator of claim 2, wherein the control module is further configured for controlling at least one of the electrode leads to electrically stimulate tissue of the patient.
5. The neurostimulator according to claim 4, wherein the control module comprises an acquisition control unit and a stimulation control unit, the acquisition control unit is used for outputting the selection signal, and the stimulation control unit is used for controlling the electrode leads to electrically stimulate the tissues of the patient.
6. The neurostimulator of claim 5, wherein the control module further comprises a signal amplification unit disposed between the electrode module and the acquisition control unit, the signal amplification unit configured to amplify the electrical signals acquired by the selected acquisition contact.
7. The neurostimulator according to claim 6, wherein the control module further comprises a filtering unit, the filtering unit is arranged between the amplifying unit and the acquisition control unit, and the filtering unit is used for filtering out interference signals in the electric signals of the selected acquisition contacts.
8. The neurostimulator of claim 4, wherein the control module further comprises an analog-to-digital conversion unit for analog-to-digital converting the electrical signal of the selected acquisition contact to convert the electrical signal into brain electrical data.
9. The neurostimulator of claim 1, further comprising a wireless communication module, wherein the controller is further configured for establishing a wireless communication connection with an external programmer via the wireless communication module, and wherein the controller is further configured for outputting electroencephalogram acquisition data;
the external program controller is used for receiving the electroencephalogram acquisition data.
10. A neurostimulation system comprising a neurostimulator of any of claims 1 to 9.
11. The neurostimulation system of claim 10, wherein the electrode module comprises at least one electrode lead, and wherein the control module is further configured for controlling the at least one electrode lead to electrically stimulate the tissue of the patient.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210125512.5A CN114452533A (en) | 2022-02-10 | 2022-02-10 | Neural stimulator and neural stimulation system |
| PCT/CN2023/074654 WO2023151538A1 (en) | 2022-02-10 | 2023-02-06 | Nerve stimulator and nerve stimulation system |
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| CN202210125512.5A CN114452533A (en) | 2022-02-10 | 2022-02-10 | Neural stimulator and neural stimulation system |
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| WO (1) | WO2023151538A1 (en) |
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| WO2023151538A1 (en) * | 2022-02-10 | 2023-08-17 | 苏州景昱医疗器械有限公司 | Nerve stimulator and nerve stimulation system |
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| CN102247137B (en) * | 2010-05-19 | 2013-06-19 | 中国科学院电子学研究所 | Microelectrode array-based multichannel neural information detection system |
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| CN114452533A (en) * | 2022-02-10 | 2022-05-10 | 苏州景昱医疗器械有限公司 | Neural stimulator and neural stimulation system |
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