CN109173047A - A kind of non-intrusion type closed loop transcranial electrical stimulation device - Google Patents
A kind of non-intrusion type closed loop transcranial electrical stimulation device Download PDFInfo
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- CN109173047A CN109173047A CN201810910152.3A CN201810910152A CN109173047A CN 109173047 A CN109173047 A CN 109173047A CN 201810910152 A CN201810910152 A CN 201810910152A CN 109173047 A CN109173047 A CN 109173047A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36014—External stimulators, e.g. with patch electrodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
- A61N1/00—Electrotherapy; Circuits therefor
- A61N1/18—Applying electric currents by contact electrodes
- A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
- A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
- A61N1/36036—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the outer, middle or inner ear
- A61N1/36038—Cochlear stimulation
- A61N1/36039—Cochlear stimulation fitting procedures
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- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Radiology & Medical Imaging (AREA)
- Otolaryngology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
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- Heart & Thoracic Surgery (AREA)
- Electrotherapy Devices (AREA)
- Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
Abstract
The invention belongs to technical field of medical equipment, specially a kind of non-intrusion type closed loop transcranial electrical stimulation device.Apparatus of the present invention include electrode cap, preamplifier, host and host computer；Electrode cap is worn in user head, includes multiple circular electrodes, the application of acquisition and electro photoluminescence for EEG signals；Preamplifier is connected by cable with electrode cap, comprising multiple selections switch and multiple amplifiers, for the acquisition of each electrode and the switching of stimulatory function and the preposition amplification of EEG signals；Host is connected by cable with preamplifier, for the acquisition of EEG signals, real-time operation, transmission and electrical transcranial stimulation signal generation；Host computer and host are wirelessly connected, the multichannel brain electric signal being recorded for receiving host and the display and the record that carry out signal；Or to the real-time parser of host download signal and Closed-loop Control Strategy.The present invention can be used for scientific experiment and rehabilitation field, carry out closed loop electro photoluminescence as feedback using multichannel brain electric signal.
Description
Technical field
The invention belongs to technical field of medical equipment, and in particular to a kind of non-intrusion type closed loop transcranial electrical stimulation device.
Background technique
Since, there are blood-brain barrier, many drug molecules can not act on brain by blood circulation system, right in human body
Alternative drug is very limited for the nervous system diseases such as Parkinson's disease, depression, autism.It is used along with long-term
After medicine as human body drug resistance and caused by curative effect reduce and drug side-effect, most of patients can not pass through cured substance.
In order to improve therapeutic effect, drug side-effect is reduced, people carry out nerveous system using the physical stimulations such as electricity, light, magnetic
The regulation of system.Special Deep brain stimulation achieves good effect in the treatment of Parkinson's disease, but brain deep electricity pierces
Sharp art needs operation of opening cranium implantable stimulation electrode and stimulation apparatus, and operation risk is larger, and indication compares limitation, is difficult to push away
Extensively into the treatment of other the nervous system diseases.
And electrical transcranial stimulation device is that electro photoluminescence is applied to patient's scalp, without operation implant electrode, therefore is had fine
Safety and replicability.But current transcranial electrical stimulation device, either still handed over through cranium through cranium direct current stimulator
Galvanic shock device belongs to open cycle system, can not adjust stimulation parameter according to the variation dynamic of patient physiological condition, can not accomplish
Accurate neuromodulation.
The present invention can acquire the multichannel physiological signal including brain electricity, myoelectricity, and pass through real-time signal analysis
Carry out closed loop adjustment effect in the electrical stimulation waveforms of patient's scalp.
Summary of the invention
The purpose of the present invention is to provide one kind can acquire including brain electricity, the multichannel physiological signal including myoelectricity and can
Realize the device of the non-intrusion type closed loop electrical transcranial stimulation based on real-time signal analysis.
Non-intrusion type closed loop transcranial electrical stimulation device provided by the invention, including electrode cap, preamplifier, host and on
Position machine；Wherein, electrode cap is directly connected by cable with preamplifier, preamplifier pass through cable directly with host phase
Even, it is wirelessly connected between host and host computer by WiFi or is directly connected to by USB cable.
The electrode cap, including elastic cap, multiple circular electrodes, a plurality of shielded wire and connection plug；Wherein, elastic force
Cap is made by soft elastic material, adjustable section, for electrode to be fixed on user head；Circular electrode is by silver/chlorine
Change silver powder to be sintered, be fixed on elastic cap according to international 10-20 brain electrode localization method, the acquisition for EEG signals
With the application of electrical transcranial stimulation；Shielded wire is made of copper core, shielded layer and insulating layer, and conducting wire is fixed on bullet by insulating materials
On power cap, each circular electrode is connected with connection plug.
The preamplifier can directly be connected with the connection plug in the electrode cap；Preamplifier includes
Multi-group electrode selection switch and amplifier；Wherein electrode selector is by circular electrode and amplifier and electrical stimulation waveforms generator
It is connected, for carrying out the switching between each electrode brain wave acquisition and electro photoluminescence function；Amplifier is put before carrying out EEG signals
Greatly, for reducing interference of the noise to signal acquisition.
The host is connected directly by cable and the preamplifier, for EEG signals acquisition, in real time
Operation, transmission and electrical transcranial stimulation signal generation；Host includes multiple filter circuits, multiple amplifiers, multiple analog-to-digital conversions
Device, microcontroller, DSP microprocessor, multiple electrical stimulation waveforms generators, WiFi communication module and usb communication module；Its
In, the filter circuit is connected with the amplifier in the preamplifier, for EEG signals to be carried out with the band of 1-100Hz
Pass filter；The amplifier is connected with the filter circuit, for carrying out second level amplification to EEG signals；The analog-to-digital conversion
Device is connected with the amplifier, for being sampled to EEG signals and being converted into digital signal；The miniature control
Device is connected with digital analog converter, DSP microprocessor, stimulus waveform generator, WiFi communication module and usb communication module, makees
Each unit operation is controlled for central processing unit；The DSP microprocessor for multichannel brain electric Signal online analysis algorithm and
The operation of Closed-loop Control Strategy；The electrical stimulation waveforms generator includes that high-speed A/D converter, isolated amplifier and selection are opened
It closes, can be controlled by the microcontroller and generate any stimulus waveform, stimulating electrode position can be by selecting switch control；Institute
WiFi communication module is stated for sending collected multichannel brain electric signal to host computer；Affiliated usb communication module be used for from
Position machine downloading multichannel brain electric Signal online analysis algorithm and Closed-loop Control Strategy.
The host computer, there are two types of connection types between microcomputer, with the host: first way is
It is wirelessly connected by WiFi, for receiving the collected multichannel brain electric signal of host and being shown and recorded；The
Two kinds of modes are by USB wired connection, for downloading multichannel brain electric Signal online analysis algorithm and Closed-loop Control Strategy
To host.
The present invention can carry out closed loop electro photoluminescence as feedback using multichannel brain electric signal；The present invention can be used for scientific experiment
With rehabilitation etc..
Detailed description of the invention
Fig. 1 is overall schematic of the present invention.
Fig. 2 is electrode cap schematic diagram of the present invention.
Fig. 3 is electrode cap distribution of electrodes figure of the present invention.
Fig. 4 is preamplifier circuit schematic diagram of the present invention.
Fig. 5 is host circuit schematic diagram of the present invention.
Fig. 6 is host moderate stimulation Wave form generator circuit schematic diagram of the present invention.
Fig. 7 is microcontroller and DSP microprocessor collaboration mode schematic diagram in this hair host.
Figure label: 1 is user, and 2 be electrode cap, and 3 be preamplifier, and 4 be host, and 5 be host computer；21 be bullet
Power cap, 22 be circular electrode, and 23 be shielded wire；31 be multiple groups selection switch, and 32 be amplifier；41 filter circuits, 42 are
Multiple amplifiers, 43 be multiple analog-digital converters, and 44 be microcontroller, and 45 be DSP microprocessor, and 46 be multiple electro photoluminescence
Waveform generator, 47 be WiFi communication module.48 be usb communication module；461 be high-speed A/D converter, and 462 be isolation amplification
Device, 463 be selection switch.
Specific embodiment
The present invention is described in further detail with reference to the accompanying drawing.
Referring to Fig. 1, brain electricity cap 2 need to be worn on the head of user 1 by when use, and electrode cap 2 and preamplifier 3 are connected
It connects, preamplifier 3 is connect with host 4, host computer 5 is connect by WiFi with host.Use can be acquired when the invention works
The multichannel scalp EEG signals of person 1, and according to multichannel brain electric Signal online analysis algorithm set in advance and closed-loop control
Strategy carries out closed loop in real time to the output waveform of electrical transcranial stimulation and adjusts, while collected original EEG signals can pass through
WiFi is sent to host computer 5 and can be shown and be recorded on host computer 5.
Referring to fig. 2, electrode cap 2 is by elastic cap 21, the multiple disk loading electrodes 22 and the shielded wire that are fixed on elastic cap 21
23 compositions, electrode cap 2 are elastic adjustable.Since electrical transcranial stimulation electric current is much larger than the size of scalp brain electricity, all conducting wires
Using shielding line to reduce the noise for coupling generation between conducting wire.The size that electrode cap 2 need to be adjusted when use, makes on electrode cap
Circular electrode close to user's scalp, and need to inject conductive paste in circular electrode 22, reduce circular electrode 22 and make
The contact impedance of user's scalp.
Referring to Fig. 3, fixed disk loading electrode 22 is distributed according to international 10-20 brain electrode location mode on electrode cap 2, disk dress
The quantity of electrode 22 includes but is not limited to 21 electrodes shown in Fig. 3.
Referring to fig. 4, preamplifier 3 includes multiple groups selection switch 31 and amplifier 32, selects switch 31 and amplifier 32
Number it is corresponding with electrode number in electrode cap 2.For each specific disk loading electrode 22, selected by corresponding selection switch
Access to selecting property amplifier 32 or the stimulus waveform generator that is directly accessed in host 3 in；When the circular electrode accesses amplifier
When, collected EEG signals are amplified device and carry out the preposition amplification of the first order, reduce influence of the noise to it；When plate-like electricity
When stimulus waveform generator is accessed in pole, the electro photoluminescence for generating stimulus waveform generator is transferred to user's scalp.
Referring to Fig. 5, host includes comprising multiple filter circuits 41, multiple amplifiers 42, multiple analog-digital converters 43, miniature
Controller 44, DSP microprocessor 45, multiple electrical stimulation waveforms generators 46, WiFi communication module 47 and usb communication module
48.The wherein number pair of the number of filter circuit 41, amplifier 42 and analog-digital converter 43 and the disk loading electrode 22 in electrode cap 2
It answers, is filtered for the scalp EEG signals to user 1, second level is amplified and sampling；Microcontroller 44 is as center control
Device processed, for controlling the work of each unit；DSP microprocessor 45 is used as arithmetic processor, real for multichannel brain electric signal
When parser and Closed-loop Control Strategy operation；Electrical stimulation waveforms generator 46 is for generating electrical transcranial stimulation waveform；WiFi
Communication module 47 is used to collected original EEG signals being sent to host computer 5；Usb communication module 48 is used for from host computer 5
Download multichannel brain electric Signal online analysis algorithm and Closed-loop Control Strategy.
Referring to Fig. 6, electrical stimulation waveforms generator 46 includes that high-speed A/D converter 461, isolated amplifier 462 and selection are opened
Close 463.Wherein high-speed A/D converter 461 is connected with microcontroller 44, for generating any stimulus waveform；Isolated amplifier
462 are connected with high-speed A/D converter, for stimulus signal to be carried out isolation amplification；Selection switch in electric stimulus generator 46
463 need to cooperate adjustment with the selection switch 31 in 3 in preamplifier, for selecting stimulating electrode.
Referring to Fig. 7, microprocessor 44 carries out Initialize installation after obtaining initiation parameter from DSP microprocessor 45,
Collected multichannel brain electric signal is transferred to DSP microprocessor 45, DSP according to fixed window length by microprocessor 44 later
Run on microprocessor 45 multichannel brain electric Signal online analysis algorithm and Closed-loop Control Strategy obtain control parameter and by its
Microprocessor 44 is sent back, the control parameter control thorn returned later by microprocessor 44 according to DSP microprocessor 45
Swash waveform generator 46 and generates response stimulus waveform.The initiation parameter includes acquisition and the selection of stimulating electrode, described
Fixation window it is long and sample rate, initiation parameter are divided in real time by the multichannel brain electric signal operated on DSP microprocessor 45
It analyses algorithm and Closed-loop Control Strategy determines.
The multichannel brain electric Signal online analysis algorithm and Closed-loop Control Strategy can be customized as needed by user.
Specific embodiment is that host computer 5 is connected by USB cable with host 4, using the software run on host computer by user oneself
The multichannel brain electric Signal online analysis algorithm and Closed-loop Control Strategy of definition are downloaded in host.
Claims (3)
1. a kind of non-intrusion type closed loop transcranial electrical stimulation device, which is characterized in that including electrode cap, preamplifier, host and
Host computer；Electrode cap is directly connected with preamplifier by cable, and preamplifier is directly connected with host by cable, main
It is wirelessly connected between machine and host computer by WiFi or is directly connected to by USB cable；Wherein:
The electrode cap, including elastic cap, multiple circular electrodes, a plurality of shielded wire and connection plug；Wherein, elastic cap by
Soft elastic material production, adjustable section, for electrode to be fixed on user head；Circular electrode is by silver/silver chlorate
It is powder sintered to form, it is fixed on elastic cap according to international 10-20 brain electrode localization method, acquisition and warp for EEG signals
The application of cranium electro photoluminescence；Shielded wire is made of copper core, shielded layer and insulating layer, and conducting wire is fixed on elastic cap by insulating materials
On, each circular electrode is connected with connection plug；
The preamplifier is directly connected with the connection plug in the electrode cap；Preamplifier includes multiple groups electricity
Pole selection switch and amplifier；Wherein, circular electrode is connected by electrode selector with amplifier and electrical stimulation waveforms generator,
For carrying out the switching between each electrode brain wave acquisition and electro photoluminescence function；EEG signals are carried out preposition amplification by amplifier, are used
In interference of the reduction noise to signal acquisition.
2. non-intrusion type closed loop transcranial electrical stimulation device according to claim 1, which is characterized in that the host leads to
Cable is crossed to be connected directly with the preamplifier；Host includes multiple filter circuits, multiple amplifiers, multiple analog-to-digital conversions
Device, microcontroller, DSP microprocessor, multiple electrical stimulation waveforms generators, WiFi communication module and usb communication module；Its
In, the filter circuit is connected with the amplifier in the preamplifier, for EEG signals to be carried out with the band of 1-100Hz
Pass filter；The amplifier is connected with the filter circuit, for carrying out second level amplification to EEG signals；The analog-to-digital conversion
Device is connected with the amplifier, for being sampled to EEG signals and being converted into digital signal；The miniature control
Device is connected with digital analog converter, DSP microprocessor, stimulus waveform generator, WiFi communication module and usb communication module, makees
Each unit operation is controlled for central processing unit；The DSP microprocessor for multichannel brain electric Signal online analysis algorithm and
The operation of Closed-loop Control Strategy；The electrical stimulation waveforms generator includes that high-speed A/D converter, isolated amplifier and selection are opened
It closes, any stimulus waveform is generated by the microcontroller control, stimulating electrode position can be by selecting switch control；It is described
WiFi communication module is used to send collected multichannel brain electric signal to host computer；The usb communication module is used for from upper
Machine downloads multichannel brain electric Signal online analysis algorithm and Closed-loop Control Strategy.
3. non-intrusion type closed loop transcranial electrical stimulation device according to claim 2, which is characterized in that the host computer is
There are two types of connection types between microcomputer, with the host: first way is to be wirelessly connected by WiFi, for connecing
It receives the collected multichannel brain electric signal of host and is shown and recorded；The second way is to pass through the wired company of USB
It connects, for multichannel brain electric Signal online analysis algorithm and Closed-loop Control Strategy to be downloaded to host.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810910152.3A CN109173047A (en) | 2018-08-10 | 2018-08-10 | A kind of non-intrusion type closed loop transcranial electrical stimulation device |
Applications Claiming Priority (1)
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|---|---|---|---|
| CN201810910152.3A CN109173047A (en) | 2018-08-10 | 2018-08-10 | A kind of non-intrusion type closed loop transcranial electrical stimulation device |
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| CN201810910152.3A Pending CN109173047A (en) | 2018-08-10 | 2018-08-10 | A kind of non-intrusion type closed loop transcranial electrical stimulation device |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110368577A (en) * | 2019-07-03 | 2019-10-25 | 天津大学 | Programmable flexibility electrical transcranial stimulation and brain wave acquisition integrated system |
| CN111346297A (en) * | 2020-03-16 | 2020-06-30 | 首都医科大学宣武医院 | Multi-target point electrical stimulation circuit, electrical stimulator and signal output method thereof |
| CN113274027A (en) * | 2021-06-17 | 2021-08-20 | 复旦大学 | In-vivo multichannel electroencephalogram signal recording device |
| CN113440690A (en) * | 2021-08-03 | 2021-09-28 | 复旦大学 | Intelligent quantitative drug administration electric needle injection device based on electromyographic signal feedback |
| CN113662552A (en) * | 2021-08-31 | 2021-11-19 | 复旦大学 | Brain electrode array evenly distributed in three-dimensional manner in apical-temporal area and preparation method thereof |
| CN113730800A (en) * | 2021-08-19 | 2021-12-03 | 深圳英智科技有限公司 | Electrode cap integrating current stimulation and electroencephalogram acquisition |
| TWI763194B (en) * | 2020-01-10 | 2022-05-01 | 臺北醫學大學 | A head cap with channel identification |
| CN114668947A (en) * | 2021-12-21 | 2022-06-28 | 北京师范大学 | Operating system and method for sleep TMR based on EEG |
| CN117919594A (en) * | 2023-12-05 | 2024-04-26 | 深圳中科华意科技有限公司 | Method, device and medium for improving individual depression by using transcranial electric stimulation |
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Cited By (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110368577A (en) * | 2019-07-03 | 2019-10-25 | 天津大学 | Programmable flexibility electrical transcranial stimulation and brain wave acquisition integrated system |
| TWI763194B (en) * | 2020-01-10 | 2022-05-01 | 臺北醫學大學 | A head cap with channel identification |
| CN111346297A (en) * | 2020-03-16 | 2020-06-30 | 首都医科大学宣武医院 | Multi-target point electrical stimulation circuit, electrical stimulator and signal output method thereof |
| CN111346297B (en) * | 2020-03-16 | 2021-03-23 | 首都医科大学宣武医院 | Multi-target point electrical stimulation circuit, electrical stimulator and signal output method thereof |
| WO2021184439A1 (en) * | 2020-03-16 | 2021-09-23 | 首都医科大学宣武医院 | Multi-target electrical stimulation circuit, electrical stimulator, and signal output method therefor |
| US11850429B2 (en) | 2020-03-16 | 2023-12-26 | Xuanwu Hospital Capital Medical University | Multi-target electrical stimulation circuit, electrical stimulator and signal output method of electrical stimulator |
| CN113274027A (en) * | 2021-06-17 | 2021-08-20 | 复旦大学 | In-vivo multichannel electroencephalogram signal recording device |
| CN113440690A (en) * | 2021-08-03 | 2021-09-28 | 复旦大学 | Intelligent quantitative drug administration electric needle injection device based on electromyographic signal feedback |
| CN113730800A (en) * | 2021-08-19 | 2021-12-03 | 深圳英智科技有限公司 | Electrode cap integrating current stimulation and electroencephalogram acquisition |
| CN113662552A (en) * | 2021-08-31 | 2021-11-19 | 复旦大学 | Brain electrode array evenly distributed in three-dimensional manner in apical-temporal area and preparation method thereof |
| CN114668947A (en) * | 2021-12-21 | 2022-06-28 | 北京师范大学 | Operating system and method for sleep TMR based on EEG |
| CN117919594A (en) * | 2023-12-05 | 2024-04-26 | 深圳中科华意科技有限公司 | Method, device and medium for improving individual depression by using transcranial electric stimulation |
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Application publication date: 20190111 |