CN114451548B - Application of Amazonia in preparing food or health-care product for improving nerve injury - Google Patents
Application of Amazonia in preparing food or health-care product for improving nerve injury Download PDFInfo
- Publication number
- CN114451548B CN114451548B CN202210190609.4A CN202210190609A CN114451548B CN 114451548 B CN114451548 B CN 114451548B CN 202210190609 A CN202210190609 A CN 202210190609A CN 114451548 B CN114451548 B CN 114451548B
- Authority
- CN
- China
- Prior art keywords
- amazonia
- lead
- amazon
- berry
- food
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 235000013305 food Nutrition 0.000 title claims abstract description 46
- 208000028389 Nerve injury Diseases 0.000 title claims abstract description 29
- 230000008764 nerve damage Effects 0.000 title claims abstract description 29
- 241000656416 Amazonia Species 0.000 title abstract description 52
- 235000021028 berry Nutrition 0.000 claims abstract description 72
- 238000009825 accumulation Methods 0.000 claims abstract description 44
- 230000036541 health Effects 0.000 claims abstract description 27
- 230000006378 damage Effects 0.000 claims abstract description 17
- 208000027418 Wounds and injury Diseases 0.000 claims abstract description 11
- 208000014674 injury Diseases 0.000 claims abstract description 11
- 230000003376 axonal effect Effects 0.000 claims abstract description 10
- 239000000203 mixture Substances 0.000 claims description 17
- 239000007788 liquid Substances 0.000 claims description 13
- 239000000843 powder Substances 0.000 claims description 12
- 235000013399 edible fruits Nutrition 0.000 claims description 11
- 238000009472 formulation Methods 0.000 claims description 7
- 235000013361 beverage Nutrition 0.000 claims description 5
- 239000008187 granular material Substances 0.000 claims description 4
- 238000002360 preparation method Methods 0.000 claims description 4
- 239000002775 capsule Substances 0.000 claims description 3
- 235000013365 dairy product Nutrition 0.000 claims description 3
- 235000015927 pasta Nutrition 0.000 claims description 3
- 239000006187 pill Substances 0.000 claims description 3
- 239000003826 tablet Substances 0.000 claims description 2
- 241001122767 Theaceae Species 0.000 claims 1
- 235000015173 baked goods and baking mixes Nutrition 0.000 claims 1
- 235000011869 dried fruits Nutrition 0.000 claims 1
- 235000021022 fresh fruits Nutrition 0.000 claims 1
- 239000000284 extract Substances 0.000 abstract description 44
- 230000000694 effects Effects 0.000 abstract description 27
- 230000001737 promoting effect Effects 0.000 abstract description 21
- 238000011160 research Methods 0.000 abstract description 12
- 241000252212 Danio rerio Species 0.000 description 48
- 239000000047 product Substances 0.000 description 32
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 24
- 238000001514 detection method Methods 0.000 description 19
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
- 230000029142 excretion Effects 0.000 description 13
- 210000005036 nerve Anatomy 0.000 description 13
- 238000011282 treatment Methods 0.000 description 12
- 235000013336 milk Nutrition 0.000 description 11
- 239000008267 milk Substances 0.000 description 11
- 210000004080 milk Anatomy 0.000 description 11
- 238000010171 animal model Methods 0.000 description 9
- 230000008929 regeneration Effects 0.000 description 9
- 238000011069 regeneration method Methods 0.000 description 9
- KQNKJJBFUFKYFX-UHFFFAOYSA-N acetic acid;trihydrate Chemical compound O.O.O.CC(O)=O KQNKJJBFUFKYFX-UHFFFAOYSA-N 0.000 description 8
- 239000004480 active ingredient Substances 0.000 description 8
- 230000006870 function Effects 0.000 description 8
- 229940046892 lead acetate Drugs 0.000 description 8
- 239000002002 slurry Substances 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 210000003050 axon Anatomy 0.000 description 6
- 238000009395 breeding Methods 0.000 description 6
- 230000001488 breeding effect Effects 0.000 description 6
- 239000003814 drug Substances 0.000 description 6
- 239000013641 positive control Substances 0.000 description 6
- 238000007619 statistical method Methods 0.000 description 6
- ACTRVOBWPAIOHC-UHFFFAOYSA-N succimer Chemical compound OC(=O)C(S)C(S)C(O)=O ACTRVOBWPAIOHC-UHFFFAOYSA-N 0.000 description 6
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 5
- 239000003153 chemical reaction reagent Substances 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 5
- 235000014571 nuts Nutrition 0.000 description 5
- 230000004224 protection Effects 0.000 description 5
- 235000002639 sodium chloride Nutrition 0.000 description 5
- 239000000126 substance Substances 0.000 description 5
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
- 206010067125 Liver injury Diseases 0.000 description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 4
- 239000003963 antioxidant agent Substances 0.000 description 4
- 230000003078 antioxidant effect Effects 0.000 description 4
- 235000006708 antioxidants Nutrition 0.000 description 4
- 239000013256 coordination polymer Substances 0.000 description 4
- 238000010438 heat treatment Methods 0.000 description 4
- 231100000753 hepatic injury Toxicity 0.000 description 4
- 238000000265 homogenisation Methods 0.000 description 4
- 210000003734 kidney Anatomy 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 230000013011 mating Effects 0.000 description 4
- 210000002161 motor neuron Anatomy 0.000 description 4
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 4
- 238000001223 reverse osmosis Methods 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000011550 stock solution Substances 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 235000013619 trace mineral Nutrition 0.000 description 4
- 239000011573 trace mineral Substances 0.000 description 4
- 230000009261 transgenic effect Effects 0.000 description 4
- 229940088594 vitamin Drugs 0.000 description 4
- 229930003231 vitamin Natural products 0.000 description 4
- 235000013343 vitamin Nutrition 0.000 description 4
- 239000011782 vitamin Substances 0.000 description 4
- 241000283690 Bos taurus Species 0.000 description 3
- 241000196324 Embryophyta Species 0.000 description 3
- 235000010469 Glycine max Nutrition 0.000 description 3
- 244000068988 Glycine max Species 0.000 description 3
- 240000007594 Oryza sativa Species 0.000 description 3
- 235000007164 Oryza sativa Nutrition 0.000 description 3
- 241001494479 Pecora Species 0.000 description 3
- CWEZAWNPTYBADX-UHFFFAOYSA-N Procyanidin Natural products OC1C(OC2C(O)C(Oc3c2c(O)cc(O)c3C4C(O)C(Oc5cc(O)cc(O)c45)c6ccc(O)c(O)c6)c7ccc(O)c(O)c7)c8c(O)cc(O)cc8OC1c9ccc(O)c(O)c9 CWEZAWNPTYBADX-UHFFFAOYSA-N 0.000 description 3
- 244000269722 Thea sinensis Species 0.000 description 3
- 229940024606 amino acid Drugs 0.000 description 3
- 235000001014 amino acid Nutrition 0.000 description 3
- 150000001413 amino acids Chemical class 0.000 description 3
- 239000006286 aqueous extract Substances 0.000 description 3
- 210000000748 cardiovascular system Anatomy 0.000 description 3
- 238000011156 evaluation Methods 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 229930003935 flavonoid Natural products 0.000 description 3
- 235000017173 flavonoids Nutrition 0.000 description 3
- 150000002215 flavonoids Chemical class 0.000 description 3
- 210000000987 immune system Anatomy 0.000 description 3
- 238000001095 inductively coupled plasma mass spectrometry Methods 0.000 description 3
- 239000012452 mother liquor Substances 0.000 description 3
- -1 phytosterol Chemical class 0.000 description 3
- 238000009372 pisciculture Methods 0.000 description 3
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Chemical compound [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 3
- 229920002414 procyanidin Polymers 0.000 description 3
- 235000004252 protein component Nutrition 0.000 description 3
- 210000004994 reproductive system Anatomy 0.000 description 3
- 235000009566 rice Nutrition 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 235000013616 tea Nutrition 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- GHOKWGTUZJEAQD-ZETCQYMHSA-N (D)-(+)-Pantothenic acid Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-ZETCQYMHSA-N 0.000 description 2
- 241000251468 Actinopterygii Species 0.000 description 2
- 235000017060 Arachis glabrata Nutrition 0.000 description 2
- 244000105624 Arachis hypogaea Species 0.000 description 2
- 235000010777 Arachis hypogaea Nutrition 0.000 description 2
- 235000018262 Arachis monticola Nutrition 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 2
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 description 2
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 2
- 244000062793 Sorghum vulgare Species 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 235000021307 Triticum Nutrition 0.000 description 2
- 244000098338 Triticum aestivum Species 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 108010046377 Whey Proteins Proteins 0.000 description 2
- 102000007544 Whey Proteins Human genes 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
- 230000001476 alcoholic effect Effects 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 235000010208 anthocyanin Nutrition 0.000 description 2
- 239000004410 anthocyanin Substances 0.000 description 2
- 229930002877 anthocyanin Natural products 0.000 description 2
- 150000004636 anthocyanins Chemical class 0.000 description 2
- 230000003110 anti-inflammatory effect Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- 210000004556 brain Anatomy 0.000 description 2
- 235000008429 bread Nutrition 0.000 description 2
- 235000012970 cakes Nutrition 0.000 description 2
- 210000004027 cell Anatomy 0.000 description 2
- 235000013339 cereals Nutrition 0.000 description 2
- 235000013351 cheese Nutrition 0.000 description 2
- 238000011109 contamination Methods 0.000 description 2
- 230000002354 daily effect Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 235000019197 fats Nutrition 0.000 description 2
- 235000013312 flour Nutrition 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 239000013538 functional additive Substances 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 229920000609 methyl cellulose Polymers 0.000 description 2
- 239000001923 methylcellulose Substances 0.000 description 2
- 210000000653 nervous system Anatomy 0.000 description 2
- 239000004006 olive oil Substances 0.000 description 2
- 235000008390 olive oil Nutrition 0.000 description 2
- 235000020232 peanut Nutrition 0.000 description 2
- 239000000419 plant extract Substances 0.000 description 2
- 150000008442 polyphenolic compounds Chemical class 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 description 2
- 238000000926 separation method Methods 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000013589 supplement Substances 0.000 description 2
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 2
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 2
- 150000004670 unsaturated fatty acids Chemical class 0.000 description 2
- 235000019158 vitamin B6 Nutrition 0.000 description 2
- 239000011726 vitamin B6 Substances 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 229940045997 vitamin a Drugs 0.000 description 2
- 229940011671 vitamin b6 Drugs 0.000 description 2
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 241001133760 Acoelorraphe Species 0.000 description 1
- 240000002234 Allium sativum Species 0.000 description 1
- 244000144725 Amygdalus communis Species 0.000 description 1
- 235000011437 Amygdalus communis Nutrition 0.000 description 1
- 244000226021 Anacardium occidentale Species 0.000 description 1
- 235000007319 Avena orientalis Nutrition 0.000 description 1
- 241000209763 Avena sativa Species 0.000 description 1
- 235000007558 Avena sp Nutrition 0.000 description 1
- 208000014644 Brain disease Diseases 0.000 description 1
- 240000007124 Brassica oleracea Species 0.000 description 1
- 235000011299 Brassica oleracea var botrytis Nutrition 0.000 description 1
- 240000003259 Brassica oleracea var. botrytis Species 0.000 description 1
- 244000178937 Brassica oleracea var. capitata Species 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 241000283707 Capra Species 0.000 description 1
- 241001070941 Castanea Species 0.000 description 1
- 235000014036 Castanea Nutrition 0.000 description 1
- GHOKWGTUZJEAQD-UHFFFAOYSA-N Chick antidermatitis factor Natural products OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 1
- OCUCCJIRFHNWBP-IYEMJOQQSA-L Copper gluconate Chemical compound [Cu+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OCUCCJIRFHNWBP-IYEMJOQQSA-L 0.000 description 1
- 240000009226 Corylus americana Species 0.000 description 1
- 235000001543 Corylus americana Nutrition 0.000 description 1
- 235000007466 Corylus avellana Nutrition 0.000 description 1
- 240000008067 Cucumis sativus Species 0.000 description 1
- 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- 244000000626 Daucus carota Species 0.000 description 1
- 235000002767 Daucus carota Nutrition 0.000 description 1
- 229920001353 Dextrin Polymers 0.000 description 1
- 239000004375 Dextrin Substances 0.000 description 1
- 108010082495 Dietary Plant Proteins Proteins 0.000 description 1
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 description 1
- 235000006581 Euterpe edulis Nutrition 0.000 description 1
- 244000185722 Euterpe edulis Species 0.000 description 1
- 235000012601 Euterpe oleracea Nutrition 0.000 description 1
- 244000207620 Euterpe oleracea Species 0.000 description 1
- 241001677214 Euterpe precatoria Species 0.000 description 1
- 206010072063 Exposure to lead Diseases 0.000 description 1
- 235000009419 Fagopyrum esculentum Nutrition 0.000 description 1
- 240000008620 Fagopyrum esculentum Species 0.000 description 1
- 235000016623 Fragaria vesca Nutrition 0.000 description 1
- 240000009088 Fragaria x ananassa Species 0.000 description 1
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 1
- 208000018522 Gastrointestinal disease Diseases 0.000 description 1
- 235000011201 Ginkgo Nutrition 0.000 description 1
- 235000008100 Ginkgo biloba Nutrition 0.000 description 1
- 244000194101 Ginkgo biloba Species 0.000 description 1
- 206010019133 Hangover Diseases 0.000 description 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 1
- 240000005979 Hordeum vulgare Species 0.000 description 1
- 235000007340 Hordeum vulgare Nutrition 0.000 description 1
- 229920001202 Inulin Polymers 0.000 description 1
- 240000007049 Juglans regia Species 0.000 description 1
- 235000009496 Juglans regia Nutrition 0.000 description 1
- 229920002752 Konjac Polymers 0.000 description 1
- ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 1
- 229930064664 L-arginine Natural products 0.000 description 1
- 235000014852 L-arginine Nutrition 0.000 description 1
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 description 1
- 229930182844 L-isoleucine Natural products 0.000 description 1
- 239000004395 L-leucine Substances 0.000 description 1
- 235000019454 L-leucine Nutrition 0.000 description 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 description 1
- ABSPRNADVQNDOU-UHFFFAOYSA-N Menaquinone 1 Natural products C1=CC=C2C(=O)C(CC=C(C)C)=C(C)C(=O)C2=C1 ABSPRNADVQNDOU-UHFFFAOYSA-N 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 239000004368 Modified starch Substances 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 description 1
- 240000002853 Nelumbo nucifera Species 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 235000010676 Ocimum basilicum Nutrition 0.000 description 1
- 240000007926 Ocimum gratissimum Species 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 240000002582 Oryza sativa Indica Group Species 0.000 description 1
- 240000008467 Oryza sativa Japonica Group Species 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- 235000004347 Perilla Nutrition 0.000 description 1
- 244000124853 Perilla frutescens Species 0.000 description 1
- 244000046052 Phaseolus vulgaris Species 0.000 description 1
- 235000008331 Pinus X rigitaeda Nutrition 0.000 description 1
- 241000018646 Pinus brutia Species 0.000 description 1
- 235000011613 Pinus brutia Nutrition 0.000 description 1
- 235000003447 Pistacia vera Nutrition 0.000 description 1
- 240000006711 Pistacia vera Species 0.000 description 1
- 240000004713 Pisum sativum Species 0.000 description 1
- 235000010582 Pisum sativum Nutrition 0.000 description 1
- 229920001213 Polysorbate 20 Polymers 0.000 description 1
- HLCFGWHYROZGBI-JJKGCWMISA-M Potassium gluconate Chemical compound [K+].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O HLCFGWHYROZGBI-JJKGCWMISA-M 0.000 description 1
- 241000353135 Psenopsis anomala Species 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 1
- 241000209056 Secale Species 0.000 description 1
- 235000007238 Secale cereale Nutrition 0.000 description 1
- 240000003768 Solanum lycopersicum Species 0.000 description 1
- 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
- 108010073771 Soybean Proteins Proteins 0.000 description 1
- 235000009337 Spinacia oleracea Nutrition 0.000 description 1
- 244000300264 Spinacia oleracea Species 0.000 description 1
- 235000010749 Vicia faba Nutrition 0.000 description 1
- 240000006677 Vicia faba Species 0.000 description 1
- 235000002098 Vicia faba var. major Nutrition 0.000 description 1
- 240000004922 Vigna radiata Species 0.000 description 1
- 235000010721 Vigna radiata var radiata Nutrition 0.000 description 1
- 235000011469 Vigna radiata var sublobata Nutrition 0.000 description 1
- 235000011453 Vigna umbellata Nutrition 0.000 description 1
- 240000001417 Vigna umbellata Species 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 229930003779 Vitamin B12 Natural products 0.000 description 1
- 229930003471 Vitamin B2 Natural products 0.000 description 1
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 1
- 235000009392 Vitis Nutrition 0.000 description 1
- 241000219095 Vitis Species 0.000 description 1
- 235000019498 Walnut oil Nutrition 0.000 description 1
- 239000005862 Whey Substances 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 241000482268 Zea mays subsp. mays Species 0.000 description 1
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 235000013334 alcoholic beverage Nutrition 0.000 description 1
- 239000012675 alcoholic extract Substances 0.000 description 1
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 235000020224 almond Nutrition 0.000 description 1
- 230000001093 anti-cancer Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- 235000013734 beta-carotene Nutrition 0.000 description 1
- 239000011648 beta-carotene Substances 0.000 description 1
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 1
- 229960002747 betacarotene Drugs 0.000 description 1
- 229960002685 biotin Drugs 0.000 description 1
- 235000020958 biotin Nutrition 0.000 description 1
- 239000011616 biotin Substances 0.000 description 1
- 235000015895 biscuits Nutrition 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 235000014121 butter Nutrition 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- FNAQSUUGMSOBHW-UHFFFAOYSA-H calcium citrate Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O FNAQSUUGMSOBHW-UHFFFAOYSA-H 0.000 description 1
- 239000001354 calcium citrate Substances 0.000 description 1
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 1
- MKJXYGKVIBWPFZ-CEOVSRFSSA-L calcium;(2s)-2-hydroxypropanoate Chemical compound [Ca+2].C[C@H](O)C([O-])=O.C[C@H](O)C([O-])=O MKJXYGKVIBWPFZ-CEOVSRFSSA-L 0.000 description 1
- 239000010495 camellia oil Substances 0.000 description 1
- 235000014171 carbonated beverage Nutrition 0.000 description 1
- 235000020226 cashew nut Nutrition 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- GRWVQDDAKZFPFI-UHFFFAOYSA-H chromium(III) sulfate Chemical compound [Cr+3].[Cr+3].[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O.[O-]S([O-])(=O)=O GRWVQDDAKZFPFI-UHFFFAOYSA-H 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- AGVAZMGAQJOSFJ-WZHZPDAFSA-M cobalt(2+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+2].N#[C-].[N-]([C@@H]1[C@H](CC(N)=O)[C@@]2(C)CCC(=O)NC[C@@H](C)OP(O)(=O)O[C@H]3[C@H]([C@H](O[C@@H]3CO)N3C4=CC(C)=C(C)C=C4N=C3)O)\C2=C(C)/C([C@H](C\2(C)C)CCC(N)=O)=N/C/2=C\C([C@H]([C@@]/2(CC(N)=O)C)CCC(N)=O)=N\C\2=C(C)/C2=N[C@]1(C)[C@@](C)(CC(N)=O)[C@@H]2CCC(N)=O AGVAZMGAQJOSFJ-WZHZPDAFSA-M 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 239000003240 coconut oil Substances 0.000 description 1
- 235000019864 coconut oil Nutrition 0.000 description 1
- 235000013353 coffee beverage Nutrition 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 235000020186 condensed milk Nutrition 0.000 description 1
- 239000000356 contaminant Substances 0.000 description 1
- 229940108925 copper gluconate Drugs 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 235000015140 cultured milk Nutrition 0.000 description 1
- 238000004042 decolorization Methods 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 235000019425 dextrin Nutrition 0.000 description 1
- 235000019700 dicalcium phosphate Nutrition 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000000378 dietary effect Effects 0.000 description 1
- 235000014113 dietary fatty acids Nutrition 0.000 description 1
- 235000013325 dietary fiber Nutrition 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- BVTBRVFYZUCAKH-UHFFFAOYSA-L disodium selenite Chemical compound [Na+].[Na+].[O-][Se]([O-])=O BVTBRVFYZUCAKH-UHFFFAOYSA-L 0.000 description 1
- 208000035475 disorder Diseases 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000021463 dry cake Nutrition 0.000 description 1
- 229940113960 edetate calcium Drugs 0.000 description 1
- 229940124274 edetate disodium Drugs 0.000 description 1
- 235000013601 eggs Nutrition 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 238000003912 environmental pollution Methods 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 239000004222 ferrous gluconate Substances 0.000 description 1
- 235000013924 ferrous gluconate Nutrition 0.000 description 1
- 229960001645 ferrous gluconate Drugs 0.000 description 1
- 230000004720 fertilization Effects 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000012847 fine chemical Substances 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000003599 food sweetener Nutrition 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- FTSSQIKWUOOEGC-RULYVFMPSA-N fructooligosaccharide Chemical compound OC[C@H]1O[C@@](CO)(OC[C@@]2(OC[C@@]3(OC[C@@]4(OC[C@@]5(OC[C@@]6(OC[C@@]7(OC[C@@]8(OC[C@@]9(OC[C@@]%10(OC[C@@]%11(O[C@H]%12O[C@H](CO)[C@@H](O)[C@H](O)[C@H]%12O)O[C@H](CO)[C@@H](O)[C@@H]%11O)O[C@H](CO)[C@@H](O)[C@@H]%10O)O[C@H](CO)[C@@H](O)[C@@H]9O)O[C@H](CO)[C@@H](O)[C@@H]8O)O[C@H](CO)[C@@H](O)[C@@H]7O)O[C@H](CO)[C@@H](O)[C@@H]6O)O[C@H](CO)[C@@H](O)[C@@H]5O)O[C@H](CO)[C@@H](O)[C@@H]4O)O[C@H](CO)[C@@H](O)[C@@H]3O)O[C@H](CO)[C@@H](O)[C@@H]2O)[C@@H](O)[C@@H]1O FTSSQIKWUOOEGC-RULYVFMPSA-N 0.000 description 1
- 229940107187 fructooligosaccharide Drugs 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 235000012055 fruits and vegetables Nutrition 0.000 description 1
- 235000020510 functional beverage Nutrition 0.000 description 1
- 235000021255 galacto-oligosaccharides Nutrition 0.000 description 1
- 150000003271 galactooligosaccharides Chemical class 0.000 description 1
- 235000004611 garlic Nutrition 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 229960002989 glutamic acid Drugs 0.000 description 1
- 229960002743 glutamine Drugs 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000000118 hair dye Substances 0.000 description 1
- 229910001385 heavy metal Inorganic materials 0.000 description 1
- 230000002519 immonomodulatory effect Effects 0.000 description 1
- 238000003125 immunofluorescent labeling Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000006698 induction Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 1
- 229960000367 inositol Drugs 0.000 description 1
- 235000021539 instant coffee Nutrition 0.000 description 1
- 235000008446 instant noodles Nutrition 0.000 description 1
- 229940029339 inulin Drugs 0.000 description 1
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- VRIVJOXICYMTAG-IYEMJOQQSA-L iron(ii) gluconate Chemical compound [Fe+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O VRIVJOXICYMTAG-IYEMJOQQSA-L 0.000 description 1
- 229960000310 isoleucine Drugs 0.000 description 1
- DLRVVLDZNNYCBX-RTPHMHGBSA-N isomaltose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)C(O)O1 DLRVVLDZNNYCBX-RTPHMHGBSA-N 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 208000017169 kidney disease Diseases 0.000 description 1
- 235000010485 konjac Nutrition 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 229960003136 leucine Drugs 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 239000001755 magnesium gluconate Substances 0.000 description 1
- 235000015778 magnesium gluconate Nutrition 0.000 description 1
- 229960003035 magnesium gluconate Drugs 0.000 description 1
- IAKLPCRFBAZVRW-XRDLMGPZSA-L magnesium;(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate;hydrate Chemical compound O.[Mg+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O IAKLPCRFBAZVRW-XRDLMGPZSA-L 0.000 description 1
- 239000011683 manganese gluconate Substances 0.000 description 1
- 235000014012 manganese gluconate Nutrition 0.000 description 1
- 229940072543 manganese gluconate Drugs 0.000 description 1
- OXHQNTSSPHKCPB-IYEMJOQQSA-L manganese(2+);(2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanoate Chemical compound [Mn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O OXHQNTSSPHKCPB-IYEMJOQQSA-L 0.000 description 1
- 235000013622 meat product Nutrition 0.000 description 1
- 229940057917 medium chain triglycerides Drugs 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 235000020124 milk-based beverage Nutrition 0.000 description 1
- 235000019713 millet Nutrition 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 235000021281 monounsaturated fatty acids Nutrition 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- 238000011328 necessary treatment Methods 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 235000001968 nicotinic acid Nutrition 0.000 description 1
- 239000011664 nicotinic acid Substances 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 235000012149 noodles Nutrition 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000019198 oils Nutrition 0.000 description 1
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
- 235000021313 oleic acid Nutrition 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 150000007524 organic acids Chemical class 0.000 description 1
- 235000005985 organic acids Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- 229940055726 pantothenic acid Drugs 0.000 description 1
- 235000019161 pantothenic acid Nutrition 0.000 description 1
- 239000011713 pantothenic acid Substances 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 210000001428 peripheral nervous system Anatomy 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 150000007965 phenolic acids Chemical class 0.000 description 1
- 150000003904 phospholipids Chemical class 0.000 description 1
- 235000019175 phylloquinone Nutrition 0.000 description 1
- 239000011772 phylloquinone Substances 0.000 description 1
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 description 1
- MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 description 1
- 229960001898 phytomenadione Drugs 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 235000020777 polyunsaturated fatty acids Nutrition 0.000 description 1
- 239000004224 potassium gluconate Substances 0.000 description 1
- 235000013926 potassium gluconate Nutrition 0.000 description 1
- 229960003189 potassium gluconate Drugs 0.000 description 1
- 229960004839 potassium iodide Drugs 0.000 description 1
- 235000007715 potassium iodide Nutrition 0.000 description 1
- 244000144977 poultry Species 0.000 description 1
- 235000008476 powdered milk Nutrition 0.000 description 1
- 238000004321 preservation Methods 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000009979 protective mechanism Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 238000004537 pulping Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 230000008261 resistance mechanism Effects 0.000 description 1
- XLXOKMFKGASILN-UHFFFAOYSA-N rhodamine red-X Chemical compound C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=C(S(=O)(=O)NCCCCCC(O)=O)C=C1S([O-])(=O)=O XLXOKMFKGASILN-UHFFFAOYSA-N 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 239000003813 safflower oil Substances 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000003441 saturated fatty acids Nutrition 0.000 description 1
- 150000004671 saturated fatty acids Chemical class 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- IFGCUJZIWBUILZ-UHFFFAOYSA-N sodium 2-[[2-[[hydroxy-(3,4,5-trihydroxy-6-methyloxan-2-yl)oxyphosphoryl]amino]-4-methylpentanoyl]amino]-3-(1H-indol-3-yl)propanoic acid Chemical compound [Na+].C=1NC2=CC=CC=C2C=1CC(C(O)=O)NC(=O)C(CC(C)C)NP(O)(=O)OC1OC(C)C(O)C(O)C1O IFGCUJZIWBUILZ-UHFFFAOYSA-N 0.000 description 1
- 239000001509 sodium citrate Substances 0.000 description 1
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
- 229960001790 sodium citrate Drugs 0.000 description 1
- 235000011083 sodium citrates Nutrition 0.000 description 1
- 239000011781 sodium selenite Substances 0.000 description 1
- 235000015921 sodium selenite Nutrition 0.000 description 1
- 229960001471 sodium selenite Drugs 0.000 description 1
- BCWRXLLYMXFJDY-UHFFFAOYSA-M sodium;4-hydroxy-4-oxo-2,3-bis(sulfanyl)butanoate Chemical compound [Na+].OC(=O)C(S)C(S)C([O-])=O BCWRXLLYMXFJDY-UHFFFAOYSA-M 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 229940001941 soy protein Drugs 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000003765 sweetening agent Substances 0.000 description 1
- 239000003760 tallow Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 229960003080 taurine Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 235000013337 tricalcium citrate Nutrition 0.000 description 1
- 229960004295 valine Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019163 vitamin B12 Nutrition 0.000 description 1
- 239000011715 vitamin B12 Substances 0.000 description 1
- 235000019164 vitamin B2 Nutrition 0.000 description 1
- 239000011716 vitamin B2 Substances 0.000 description 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
- 235000005282 vitamin D3 Nutrition 0.000 description 1
- 239000011647 vitamin D3 Substances 0.000 description 1
- 229940021056 vitamin d3 Drugs 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 235000020234 walnut Nutrition 0.000 description 1
- 239000008170 walnut oil Substances 0.000 description 1
- 235000021119 whey protein Nutrition 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/03—Products from fruits or vegetables; Preparation or treatment thereof consisting of whole pieces or fragments without mashing the original pieces
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L19/00—Products from fruits or vegetables; Preparation or treatment thereof
- A23L19/09—Mashed or comminuted products, e.g. pulp, purée, sauce, or products made therefrom, e.g. snacks
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
The invention belongs to the technical field of foods, and particularly relates to application of Amazonia in preparing foods or health-care products for improving lead accumulation and nerve damage caused by lead accumulation. The research result of the invention shows that the Amazonia berry or the extract thereof has the effect of promoting the discharge of lead elements in organisms, and simultaneously the Amazonia berry also has the effect of relieving and improving nerve injury, particularly motor nerve injury and axonal injury caused by lead accumulation. In addition, the technical scheme of the invention has no special requirements on the application mode of the Amazonia and the food or health care product form containing the Amazonia or the extract thereof, has the convenience in implementation, and provides a new thought for the application research of the Amazonia and similar plants thereof.
Description
Technical Field
The invention belongs to the technical field of foods, and particularly relates to application of Amazonia in preparing foods or health-care products for improving lead accumulation and nerve damage caused by lead accumulation.
Background
Lead has been used in industry for a long time, but its toxicity has been recognized for hundreds of years ago. Studies have shown that lead can cause a series of physiological and biochemical changes, and can affect the functions of the central and peripheral nervous system, cardiovascular system, reproductive system, and immune system, causing gastrointestinal, liver, kidney, and brain diseases.
With the increasing severity of environmental pollution, natural lead can enter the human body through food, drinking water and the like, wherein most of the lead is accumulated in bones, and the rest of the lead is distributed to various tissues and organs of the whole body along with the blood circulation flow. Children and pregnant women are particularly susceptible to lead, which accumulates to reduce the mental, learning and perceived comprehension of the child, and is inattentive, restless, impulsive and causes a disorder in language learning. However, lead accumulation is chronic, and causes physical discomfort only when the lead content in the human body reaches a certain level, and when physiological symptoms occur, often a physical injury that is difficult to reverse has already occurred.
Current means of prevention of lead accumulation mainly include cutting off the source of contamination, keeping away from the lead contamination area and improving dietary structure. In general, pharmacological intervention is only performed when the blood lead concentration reaches a certain level. The medicines for clinically intervening in lead accumulation mainly comprise sodium dimercaptosuccinate, edetate disodium and calcium, and the like, and the medicines have good lead-removing effect, but can lead trace elements necessary for human body loss parts, can cause damage to kidneys, have great side effects, and have little significance in reversing nerve damage caused by lead accumulation.
Therefore, avoiding the intake of lead and promoting the excretion of lead in daily life are the best ways to avoid the accumulation of lead and its damage.
In addition, amazon (agai Berry), also known as Acai Berry, is mainly distributed in the river basin of amazon south america, and is known for its excellent antioxidant ability. The Amazonia contains various nutritional substances such as unsaturated fatty acid, phytosterol, amino acid, vitamins, minerals, trace elements and the like, and also contains various functional active substances mainly including various polyphenols such as flavonoids, anthocyanin, phenolic acid and the like.
As is known, many studies have been conducted on the activity and function of amazon berry, and the activities and functions disclosed at present include antioxidant activity, anti-inflammatory activity, immunomodulation, skin whitening, anti-hangover and liver protection, anti-genotoxicity and anticancer activity. For example: research of Jinfa and the like in cited document 1 shows that procyanidins can protect liver injury caused by oxygen free radicals, chemical induction, ethanol, heavy metal ions and the like; studies by Wang Linyuan et al in cited document 2 indicate that brazil berry has a protective effect on alcoholic liver injury, and that this protective mechanism is related to its antioxidant and anti-inflammatory capacity.
Although Amazonia or processed products thereof have been used in health products and foods, there is still a prospect for research and development of new efficacy of Amazonia, and in addition, there is no verifiable public information about the function of Amazonia in promoting lead excretion of organisms, and no report about the improvement of nerve damage caused by lead accumulation.
Citation literature:
citation 1: jinfa, procyanidins in liver injury [ J ], chinese medical engineering 2012,20 (06): 62-63.
Citation 2: wang Linyuan and the like, and the oxidation resistance mechanism research (abstract) of the protection effect of the Brazil berry on alcoholic liver injury [ C ], and the seventh clinical Chinese academy of medicine, 2014, and the academy of clinical Chinese academy of medicine, 2014:49.
Disclosure of Invention
Problems to be solved by the invention
Based on the above studies of efficacy of Amazon berries in the prior art, in general, the present invention, when studying the possible biological efficacy of Amazon berries, has newly found that Amazon berries or extracts thereof (active ingredients) have a remarkable efficacy for promoting lead excretion in organisms, and has unexpectedly found that Amazon berries or extracts thereof (active ingredients) have a remarkable efficacy for improving nerve damage caused by lead accumulation.
Therefore, the primary object of the invention is to provide a new use of Amazonia berry or its extract (active ingredient), in particular to provide a use of Amazonia berry or its extract in preparing food or health care products for facilitating lead-removing effect.
It is also known that symptoms known for lead accumulation are often manifested as lesions of the nervous system, cardiovascular system, reproductive system, immune system functions, gastrointestinal tract, liver and kidney and brain, and that medical interventions may exclude lead elements from the human body, but that different interventions may also differ for relief of different symptoms.
Further studies of the present invention have also shown that amazon berry or an extract (active ingredient) thereof has a verifiable effect in improving nerve damage due to lead accumulation. According to the invention, zebra fish is taken as a research object, and the nerve injury function caused by improving lead accumulation of Amazon berries is verified and displayed from two aspects of promoting motor nerve regeneration and improving axonal injury.
In addition, the invention also provides the use of a food or health care product comprising Amazonia berry or an extract (active ingredient) thereof for promoting lead excretion in organisms and improving or alleviating nerve damage caused by lead accumulation.
Solution for solving the problem
The invention discovers that the technical problems can be solved by the following technical scheme:
[1] use of Amazonia berry or its extract in preparing food or health product for improving nerve injury caused by lead accumulation is provided.
[2] The use according to [1], wherein the amazon comprises an amazon fresh, an amazon dried, an amazon frozen, an amazon lyophilized, an amazon puree, or other food acceptable form; the Amazonia extract comprises an aqueous extract and an alcohol extract; the Amazonia extract is liquid, solid or semisolid.
[3] The use according to [1] or [2], wherein the food or health product has an effect of promoting motor nerve regeneration.
[4] The use according to [1] or [2], wherein the food or health product has an effect of improving damage to axons.
[5] The use according to any one of [1] to [4], wherein the food or health product is a powdery infusible food, a baked food, a beverage, a milk, a dairy product, a pasta or an oral preparation.
[6] The use according to [5], wherein the oral preparation comprises a tablet, a pill, a granule, a powder, a tea, a capsule and an oral liquid.
[7] A food or health product having an effect of improving nerve damage caused by lead accumulation, characterized in that the food or health product contains amazon berry or an extract thereof.
[8] The food or health product according to [7], wherein the Amazon berry comprises fresh Amazon berry, dried Amazon berry, frozen Amazon berry, puree of Amazon berry, freeze-dried Amazon berry or other food acceptable forms; the Amazonia extract comprises an aqueous extract and an alcohol extract; the Amazonia extract is liquid, solid or semisolid.
[9] The food or health product according to [7] or [8], characterized in that it further comprises other plants or extracts thereof, milk-containing components, animal components, functional additive components, trace element supplements and/or any food acceptable auxiliary materials.
[10] The use of the food or health product according to any one of [7] to [9] for producing a product for improving nerve damage caused by lead accumulation.
ADVANTAGEOUS EFFECTS OF INVENTION
Based on the implementation of the technical scheme, the invention can obtain the following technical effects:
1) The experimental data of the invention show that Amazon berry has the effect of promoting the excretion of lead element in organisms;
2) Further research of the invention shows that Amazon berry has the effects of relieving and improving nerve injury caused by lead accumulation, in particular motor nerve injury and axonal injury caused by lead accumulation;
3) The technical scheme of the invention has no special requirements on the application mode of the Amazonia and the food or health care product form containing the Amazonia or the extract thereof, and has convenient implementation;
4) The invention provides a new application mode of Amazonia berry or extract components thereof, and provides a new thought for application research of Amazonia berry and similar plants thereof.
Drawings
Fig. 1: the detection result of the lead content in the zebra fish body after the treatment of the Amazonia berry jam; wherein p <0.05, p <0.01 compared to model control.
Fig. 2: typical graphs of zebra fish axomic cell number detection results after treatment of Amazon berry jam; wherein the dotted line box is the zebra fish analysis site axon (square with side length of 200 μm).
Fig. 3: the detection result of the number of zebra fish axostoma cells after the treatment of the Amazon berry jam; wherein p <0.001 compared to the model control group.
Fig. 4: typical graphs of the detection results of the motor nerves of the zebra fish after the treatment of the Amazon berry jam; wherein the dotted line frame is three motor nerves above the zebra fish analysis part colonial holes, and the dotted line is zebra fish motor nerves.
Fig. 5: zebra fish motor nerve length detection results after the Amazon berry jam treatment; wherein p <0.05, p <0.001 compared to the model control group.
Detailed Description
The following describes embodiments of the present invention, but the present invention is not limited thereto. The present invention is not limited to the configurations described below, and various modifications are possible within the scope of the invention as claimed, and embodiments and examples obtained by appropriately combining the technical means disclosed in the different embodiments and examples are also included in the technical scope of the present invention.
In the present specification, the numerical range indicated by the term "numerical value a to numerical value B" means a range including the end point numerical value A, B.
In the present specification, a numerical range indicated by "above" or "below" is a numerical range including the present number.
In the present specification, the meaning of "can" includes both the meaning of performing a certain process and the meaning of not performing a certain process.
In this specification, the use of "optional" or "optional" means that certain substances, components, steps of performing, conditions of applying, etc. may or may not be used.
In the present specification, unless otherwise specified, "normal temperature" as used herein refers generally to a temperature of 25 ℃.
In the present specification, unit names used are international standard unit names, and "%" used represent weight or mass% unless otherwise specified.
Reference throughout this specification to "some specific/preferred embodiments," "other specific/preferred embodiments," "an embodiment," and so forth, means that a particular element (e.g., feature, structure, property, and/or characteristic) described in connection with the embodiment is included in at least one embodiment described herein, and may or may not be present in other embodiments. In addition, it is to be understood that the elements may be combined in any suitable manner in the various embodiments.
In the present invention, "lead accumulation" and "lead accumulation" mean that the content of lead in the living body gradually increases as the lead is absorbed by the living body.
In the present invention, "nerve injury" refers only to the symptom of nerve injury caused by lead intake, lead accumulation or lead accumulation, and may include motor nerve injury, axonal injury, and the like.
Unless defined otherwise, other technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs.
The amazon berry is a fruit growing on a palm tree in the united states and the ramerican region, and is also called brazil berry (Euterpe edulis mart., euterpe precatoria mart., euterpe oleracea mart.). Amazon berries described herein include, but are not limited to, fresh Amazon berries, dried Amazon berries, frozen Amazon berries, freeze-dried Amazon berries, amazon berry puree, or other food acceptable forms.
The invention discovers a new efficacy of Amazonia frutescens or an extract (active ingredient) thereof through biological research, and expands the application mode of the Amazonia frutescens in the prior art based on the research. The invention is mainly based on the following findings:
according to the invention, zebra fish is taken as a research object, water containing a certain concentration of Amazonia berry extract is used for feeding, biological changes of the zebra fish fed under the condition that water contains lead elements are researched within the safe concentration range of Amazonia berry extract, and the Amazonia berry has effects of reducing lead accumulation and removing lead for organisms through actual experimental data, so that nerve damage caused by lead accumulation can be further improved.
(Amazonia berry or extract thereof)
In the present invention, the above Amazonia fruit or its treated product can be used as it is. In some exemplary embodiments, the fruit may be crushed (optionally including beating, homogenizing, etc.) to provide a slurry, or the fruit may be freed of a substantial portion of the moisture to provide a substantially dry processed product (e.g., a dry cake, powder, or freeze-dried product, etc.), or the amazon fruit may be fermented in the presence of the requisite strain to provide a fermented product. For these fruits or their treatments, one or a mixture of them in any form or ratio may be used. In general, these fruits or their treatments can be used as they are after necessary treatments such as sterilization, or can be used after freezing and preservation.
In addition, in the present invention, an extract of Amazonia may be used. The extract is a component containing an active material or an active material of Amazonia obtained by separation and concentration by optional extraction or processing means. These actives mainly include anthocyanins, procyanidins, various flavonoids (flavonoids) and various unsaturated fatty acids including oleic acid, linoleic acid, palmitic acid, etc.
The Amazonia extract includes, but is not limited to, an aqueous or alcoholic extract thereof. In some embodiments of the present invention, fresh Amazon fruit may be pulped by a pulping machine, and the resulting pulp may be mixed with an extraction solvent (water, alcohol or a mixture thereof) and the active ingredient extracted with heating. The amount of the solvent is not particularly limited, and may be generally used in an amount of 5 to 50 times (by volume) the slurry. In some preferred embodiments, the heating may be performed at 60 to 100 ℃ for a period of time ranging from 1 to 3 hours. Too high a heating temperature or too long a time may cause oxidative deterioration of the active ingredient. After the heat treatment, the solid-liquid component may be separated, and further, the liquid component may be dried to obtain an extract of a solid (for example, in a powder form) or a semisolid (aqueous slurry). The mixed system may be subjected to adsorption decolorization before or after solid-liquid separation as needed, or may be subjected to sterilization and disinfection after the final extract is obtained.
In the present invention, the final form of the Amazonia extract is not particularly limited, and may be, for example, liquid (with the aid of a desired solvent), semisolid (aqueous slurry), powder, granule or cake (pressed), etc. In some specific embodiments, the Amazonia extract of the present invention contains rich nutrients such as polyphenols, amino acids, fatty acids, vitamins, etc.
(edible composition)
The invention further provides an edible composition, and the composition comprises the amazon berry or extract thereof described above.
In some specific embodiments, the Amazonia or extract thereof may be used as a dry, solution or slurry (fruit slurry), preferably as an aqueous slurry. These aqueous slurries generally have a soluble solid content of 8 mass% or more, preferably 10 mass%, further preferably 14 mass% or more, and have a viscous appearance.
The compositions according to the invention may comprise, in addition to the essential components described above, other optional ingredients according to the requirements of the final product, which may be exemplified by:
a milk-containing component or a protein component, the milk-containing component including milk including fresh milk derived from raw fresh cow (sheep) milk, powdered milk, whey protein, cheese, or the like; the protein component may be derived from vegetable proteins, such as soy protein, peanut protein, and the like.
Plant or plant extract components including fruits or their extracts such as fructus fici, fructus Punicae Granati, fructus Actinidiae chinensis, fructus Citri Tangerinae, fructus Citri Junoris, fructus Ananadis Comosi, strawberry, fructus Mali Pumilae, rubber, fructus Vitis Viniferae, fructus Pyri, fructus Pruni Pseudocerasi, fructus Myrtilli, rubi fructus and fructus Mori; fruit and vegetable substances such as oceanic, cucumber, tomato, cauliflower, carrot, spinach, cabbage mustard, head cabbage, garlic, basil, and herba Cymbopogonis Citrari, or extracts thereof; grains such as rice (indica rice, japonica rice, glutinous rice), wheat (wheat, barley, oat, rye), corn, sorghum, millet, yellow rice, buckwheat, soybean, broad bean, pea, mung bean, red bean, kidney bean, etc., or their extracts; nut substances such as walnut, cashew nut, hazelnut, almond, pine nut, pistachio nut, peanut, melon seed, chestnut, hawaii nut, ginkgo nut and the like or extracts thereof; coffee or an extract thereof.
Animal components including meat product components of cattle, sheep, fish or poultry.
A fat component, which may include at least one of saturated fatty acids, polyunsaturated fatty acids, monounsaturated fatty acids, OPO structured fat, DHA, EPA, ARA, phospholipids, more specifically safflower seed oil, walnut oil, peanut oil, soybean oil, alglycerol, olive oil, tea oil, mera seed oil, olive oil, coconut oil, perilla oil, deep sea fish oil, cocoa butter, palm oil, tallow, butter, lard, medium chain triglycerides or lecithins, and the like.
Functional additive components including vitamins (one or more of vitamin A, beta-carotene, vitamin D3, vitamin E, vitamin K1, vitamin B2, vitamin B6, vitamin B12, vitamin C, pantothenic acid, folic acid, nicotinic acid, choline, inositol, biotin), starch, modified starch, amino acids (L-lysine-L-glutamic acid, L-arginine, L-tryptophan, L-glutamine, taurine, L-valine, L-isoleucine or L-leucine, etc.), chinese medicine or Chinese medicine extract, dietary fiber (inulin, konjak powder, galactooligosaccharide, fructooligosaccharide, isomaltooligosaccharide, soybean polysaccharide, cyclodextrin, resistant dextrin or soybean fiber, etc.).
The trace element supplement may include metal ion salts of organic acids, such as one or more of calcium citrate, calcium L-lactate, calcium hydrogen phosphate, potassium gluconate, sodium citrate, ferrous gluconate, potassium iodide, zinc gluconate, sodium selenite, copper gluconate, chromium sulfate, manganese gluconate, and magnesium gluconate.
Any food acceptable auxiliary material including, but not limited to, antioxidants, flavoring agents, stabilizers, emulsifiers, edible sweeteners, edible colors, and the like.
In some preferred embodiments, the edible composition comprises amazon or an extract thereof, an antioxidant vitamin (vitamin a, vitamin C, vitamin E, vitamin B6, etc.) and a protein component.
The content of the amazon berry or an extract thereof in the composition is not particularly limited in principle. In some specific embodiments of the present invention, the content of the amazon berry or the extract thereof is 0.3 mass% or more, preferably 1 mass% or more, more preferably 5 mass% or more, and the upper limit of the content thereof is not particularly limited, and may be generally 60 mass% or less, preferably 30 mass% or less, more preferably 20 mass% or less, on a dry weight basis, from the viewpoint of having a desired lead removing effect.
(food or health products)
Further, the invention provides a food or health care product based on Amazonia or an extract thereof or based on the edible composition.
The specific form of the food or health product of the present invention is not particularly limited, and in some specific embodiments, the food or health product may be a powdery infusible food (instant coffee, cereal flour, nut flour, lotus root starch, etc.), a baked food (bread, cake, biscuit-based baked food, etc.), a beverage (carbonated beverage, juice beverage, functional beverage, tea-based beverage, milk beverage, alcoholic beverage, etc.), milk and dairy products (fresh milk, milk powder, whey powder, fermented milk, cheese, condensed milk, etc. derived from raw and fresh cow (sheep) milk), a pasta product (dried noodles, instant noodles, steamed bread, steamed stuffed bun, dumpling, wonton, etc.), or the like.
In other preferred embodiments, the health care product of the present invention is an oral preparation, including but not limited to tablets, pills, granules, powders, tea, capsules, oral liquids, and the like.
(use for avoiding lead accumulation and improving nerve damage caused by lead accumulation)
Further, the present invention proposes for the first time the use of Amazonia berry or its extract for the excretion of lead from organisms or for the reduction of lead accumulation in organisms, and therefore the above-mentioned edible composition as well as food or health products can be used for the above-mentioned use. Therefore, the invention considers that the eating of the food or the health care products can effectively reduce the occurrence of physiological discomfort caused by the accumulation of lead in organisms, especially human bodies.
The term "lead accumulation" as used herein refers to the phenomenon of lead accumulation in living bodies caused by excessive lead intake. The excess lead intake is mainly from: exposure to lead-containing environments, such as lead-containing contaminant environments, automobile exhaust, lead-containing pigments and coatings, and the like; ingestion of lead-containing foods such as preserved eggs, puffed foods, canned iron-sheet beverages, popcorn, tap water stored in lead-containing pipes for a long period of time, and the like; some lead-containing cosmetics, hair dyes, etc.
Lead can often accumulate and cause damage to organisms, particularly the nervous system, cardiovascular system, reproductive system, immune system functions, gastrointestinal tract, liver and kidney and brain of the human body, leading to various pathological conditions. The research of the invention finds that the food or the health care product has the effects of preventing, relieving or improving nerve injury, particularly motor nerve injury and axonal injury caused by lead accumulation.
In addition, the food or health care product is suitable for all people in principle, is especially suitable for people with high exposure risk to lead elements, and can correspondingly adjust the components in the food or health care product for people with different characteristics.
Examples
In order to more clearly describe the technical solution of the present invention, the following description is further given by way of specific examples, but not by way of limitation, only some examples of the present invention. Unless otherwise indicated, the instruments, reagents, materials, laboratory animals, etc. used in the present invention are all available through conventional commercial means.
According to the invention, zebra fish is taken as a research object, and on the basis of finding a proper application concentration, the nerve injury function caused by improving lead accumulation of Amazon berries is verified and displayed in three aspects of promoting lead excretion, promoting motor nerve regeneration and improving axonal injury.
Example 1: maximum detection concentration (MTC) assay
1. Detection material
1.1 sample formulation information
The Amazonia jam is added into the stock solution after homogenization and frozen at the temperature of minus 20 ℃.
1.2 laboratory animals
Zebra fish are all cultivated in water for fish cultivation at 28 deg.C (water quality: 200mg instant sea salt is added into 1L reverse osmosis water, conductivity is 450-550 mu S/cm, pH is 6.5-8.5, hardness is 50-100 mg/L (CaCO) 3 ) Provided by Hangzhou Cyclothe biotechnology Co., ltd., the use license number of the experimental animal is: SYXK (Zhe) 2012-0171, the feeding management meets the requirements of International AAALAC authentication (authentication number: 001458).
Transgenic motor neuron fluorescent NBT strain zebra fish is carried out in a natural pairing mating propagation mode. Zebra fish aged 6 hours after fertilization (6 hpf) were used for maximum detection concentration (MTC) determination of lead excretion promotion efficacy of amazon berry jam.
1.3 instruments, consumables and reagents
Dissecting microscope (SZX 7, OLYMPUS, japan); CCD camera (VertA 1, shanghai Tusen Vision technologies Co., ltd.); precision electronic balances (CP 214, OHAUS, USA); 6-well plates (Nest Biotech, china).
Lead acetate trihydrate (lot number D2101282, china, shanghai aladine biochemical technologies inc.).
2. Detection method
6hpf transgenic motor neuron fluorescent NBT strain zebra fish were randomly selected in 6-well plates with 30 tails per well (experimental group). Amazon berry jam (concentrations shown in Table 1) was given in water-soluble form, and a normal control group and a model control group were set at 3mL per well. Except for the normal control group, all the other experimental groups are water-soluble to administer lead acetate trihydrate to establish a zebra fish lead accumulation model. And changing the liquid every day, and after treatment for 4 days at 28 ℃, determining the MTC of the Amazonia berry jam on the lead accumulation model zebra fish.
3. Detection result
Under the experimental conditions, the MTC of the Amazonia berry jam on the lead accumulation model zebra fish is 20.0 mu L/mL. See table 1 for details:
table 1 amazon berry jam lead excretion promoting efficacy concentration fuzzing experimental results (n=30)
Example 2: lead excretion promoting efficacy determination
1. Detection material
1.1 sample formulation information
The Amazonia jam is added into the stock solution after homogenization and frozen at the temperature of minus 20 ℃.
Positive control: dimercaptosuccinic acid, white powder, lot number C1810021, shanghai Ala Biochemical technologies Co., ltd., frozen at-20 ℃. Prepared into 12.5mg/mL mother liquor by DMSO and frozen at-20 ℃.
1.2 laboratory animals
Zebra fish are all bred in water for fish farming at 28 ℃ (water quality: 200mg of instant sea salt is added into 1L of reverse osmosis water, conductivity is 450-550 mu S/cm, pH is 6.5-8.5, hardness is 50-100 mg/L (CaCO 3), and the zebra fish is provided by Hangzhou Cyclotite biotechnology Co., ltd., and the use license number of experimental animals is SYXK 2012-0171, and breeding management meets the requirements of international AAALAC certification (authentication number: 001458).
Wild type AB strain zebra fish is bred in a natural pairing mating breeding mode. Zebra fish with the age of 6hpf is used for evaluating the efficacy of promoting lead excretion of the Amazonia berry jam.
1.3 instruments, consumables and reagents
Dissecting microscope (SZX 7, OLYMPUS, japan); CCD camera (VertA 1, shanghai Tusen Vision technologies Co., ltd.); precision electronic balances (CP 214, OHAUS, USA); 6-well plates (Nest Biotech, china); inductively coupled plasma mass spectrometry (ICP-MS, type thermoelectric XII, thermo, USA).
Lead acetate trihydrate (lot number D2101282, shanghai aladine biochemical technologies inc., china), nitric acid (lot number 20210609, hana high-crystal fine chemical company, china); dimethyl sulfoxide (DMSO, lot number BCCD8942, sigma, switzerland).
2. Detection method
The 6hpf wild type AB strain zebra fish were randomly selected in 6 well plates, 30 zebra fish were treated in each well (experimental group), and 6 parallel experiments were set. The Amazon berry jam (the concentration is shown in Table 2) is given in water, the concentration of the positive control dimercaptosuccinic acid is 125 mug/mL, and the normal control group and the model control group are set at the same time, and the capacity of each hole is 3mL.
Except for the normal control group, all the other experimental groups are water-soluble to administer lead acetate trihydrate to establish a zebra fish lead accumulation model. Changing liquid every day, treating at 28deg.C for 4 days, collecting zebra fish sample, detecting lead content in zebra fish body by ICP-MS, analyzing lead content in zebra fish body, and evaluating lead-removing promoting effect of Amazon berry jam by statistical analysis result of the above indexes.
Statistical treatment results are expressed in mean+ -SE. Statistical analysis was performed with SPSS26.0 software, p <0.05 indicated that the differences were statistically significant.
3. Detection result
Under the experimental conditions, the Amazonia berry jam has the effect of promoting lead discharge. See table 2 and figure 1 for details.
Table 2 experimental results of evaluation of efficacy of amazon jam in promoting lead excretion (n=3)
Note that: p <0.05, < p <0.01 compared to model control.
Example 3: determination of protective efficacy against damage to axons caused by lead accumulation
1. Detection material
1.1 sample formulation information
The Amazonia jam is added into the stock solution after homogenization and frozen at the temperature of minus 20 ℃.
Positive control: dimercaptosuccinic acid, white powder, lot number C1810021, shanghai Ala Biochemical technologies Co., ltd., frozen at-20 ℃. Prepared into 12.5mg/mL mother liquor by DMSO and frozen at-20 ℃.
1.2 laboratory animals
Zebra fish are all bred in water for fish farming at 28 ℃ (water quality: 200mg of instant sea salt is added into 1L of reverse osmosis water, conductivity is 450-550 mu S/cm, pH is 6.5-8.5, hardness is 50-100 mg/L (CaCO 3), and the zebra fish is provided by Hangzhou Cyclotite biotechnology Co., ltd., and the use license number of experimental animals is SYXK 2012-0171, and breeding management meets the requirements of international AAALAC certification (authentication number: 001458).
Wild type AB strain zebra fish is bred in a natural pairing mating breeding mode. Zebra fish with the age of 6hpf is used for evaluating the protection effect of the amazon jam axonal injury.
1.3 instruments, consumables and reagents
Dissecting microscope (SZX 7, OLYMPUS, japan); CCD camera (VertA 1, shanghai Tusen Vision technologies Co., ltd.); electrokinetically focused continuously variable magnification fluorescence microscope (AZ 100, nikon, japan); precision electronic balances (CP 214, OHAUS, USA); 6-well plates (Nest Biotech, china).
Lead acetate trihydrate (lot D2101282, gladine biochemical technologies, china), dimethyl sulfoxide (DMSO, lot BCCD8942, sigma, switzerland); methylcellulose (lot B2006074, china, gladine biochemical technologies inc.); tween-20 (lot number K1715077, shanghai Alasdine Biochemical technologies Co., ltd.); tritonx-100 (lot number K1914021, shanghai Ala Biochemical technologies Co., ltd., china); monoclone Anti-Tubulin (lot 075M4860V, sigma, switzerland); rhodamine Red-X-conjugated Affinipure Goat Anti-Mouse LgG+lgM (H+L) (lot 152015, jackson, USA); PBS buffer (lot 70115000, biosharp, china).
2. Detection method
The 6hpf wild type AB strain zebra fish were randomly selected in 6-well plates, and 30 zebra fish were treated in each well (experimental group). The Amazon berry jam (the concentration is shown in Table 3) is given in water, the concentration of the positive control dimercaptosuccinic acid is 125 mug/mL, and the normal control group and the model control group are set at the same time, and the capacity of each hole is 3mL. Except for the normal control group, all the other experimental groups are water-soluble to administer lead acetate trihydrate to establish a zebra fish lead accumulation model. After the whole zebra fish is subjected to immunofluorescence staining by using an axon specific antibody after the liquid is changed every day and treated for 4 days at 28 ℃, 10 zebra fish are randomly selected from each experimental group after the staining is finished and are photographed under a fluorescence microscope, the data are analyzed and collected by using NIS-Elements D3.20 advanced image processing software, the number of axon cells at the head of the zebra fish (fluorescence intensity) is analyzed, and the protection effect of the axostoma cable jam is evaluated by using the statistical analysis result of the index.
Statistical treatment results are expressed in mean+ -SE. Statistical analysis was performed with SPSS26.0 software, p <0.05 indicated that the differences were statistically significant.
3. Detection result
Under the experimental conditions, the amazon berry jam has obvious effect of protecting the damage of the axons. See table 3, fig. 2 and fig. 3 for details.
Table 3 amazon jam axonal injury protection efficacy evaluation experiment results (n=10)
Note that: p <0.001 compared to model control.
Example 4: regeneration promoting efficacy assay for motor nerve damage caused by lead accumulation
1. Detection material
1.1 sample formulation information
The Amazonia jam is added into the stock solution after homogenization and frozen at the temperature of minus 20 ℃.
Positive control: dimercaptosuccinic acid, white powder, lot number C1810021, shanghai Ala Biochemical technologies Co., ltd., frozen at-20 ℃. Prepared into 12.5mg/mL mother liquor by DMSO and frozen at-20 ℃.
1.2 laboratory animals
Zebra fish are all bred in water for fish farming at 28 ℃ (water quality: 200mg of instant sea salt is added into 1L of reverse osmosis water, conductivity is 450-550 mu S/cm, pH is 6.5-8.5, hardness is 50-100 mg/L (CaCO 3), and the zebra fish is provided by Hangzhou Cyclotite biotechnology Co., ltd., and the use license number of experimental animals is SYXK 2012-0171, and breeding management meets the requirements of international AAALAC certification (authentication number: 001458).
Transgenic motor neuron fluorescent NBT strain zebra fish is carried out in a natural pairing mating propagation mode. Zebra fish with the age of 6hpf is used for evaluating the motor nerve regeneration promoting efficacy of the Amazonia berry jam.
1.3 instruments, consumables and reagents
Dissecting microscope (SZX 7, OLYMPUS, japan); CCD camera (VertA 1, shanghai Tusen Vision technologies Co., ltd.); electrokinetically focused continuously variable magnification fluorescence microscope (AZ 100, nikon, japan); precision electronic balances (CP 214, OHAUS, USA); 6-well plates (Nest Biotech, china).
Lead acetate trihydrate (lot D2101282, gladine biochemical technologies, china), dimethyl sulfoxide (DMSO, lot BCCD8942, sigma, switzerland); methylcellulose (lot B2006074, china, shanghai Ala Biochemical technologies Co., ltd.).
2. Detection method
The 6hpf transgenic motor neuron fluorescent NBT strain zebra fish was randomly selected in 6-well plates, and 30 zebra fish were treated in each well (experimental group). The Amazon berry jam (the concentration is shown in Table 4) is given in water, the concentration of the positive control dimercaptosuccinic acid is 125 mug/mL, and the normal control group and the model control group are set at the same time, and the capacity of each hole is 3mL. Except for the normal control group, all the other experimental groups are water-soluble to administer lead acetate trihydrate to establish a zebra fish lead accumulation model. After daily liquid exchange and treatment for 4 days at 28 ℃, 10 zebra fish are randomly selected from each experimental group, photographed under a fluorescent microscope, analyzed and data are collected by NIS-Elements D3.20 advanced image processing software, the length (average value) of three motor nerves above the zebra fish breeding holes is analyzed, and the motor nerve regeneration promotion effect of the Amazon berry jam is evaluated according to the statistical analysis result of the indexes.
Statistical treatment results are expressed in mean+ -SE. Statistical analysis was performed with SPSS26.0 software, p <0.05 indicated that the differences were statistically significant.
3. Detection result
Under the experimental conditions, the Amazonia berry jam has the effect of promoting motor nerve regeneration. See table 4, fig. 4 and fig. 5 for details:
table 4 experimental results of evaluation of motor nerve regeneration promoting efficacy of amazon berry jam (n=10)
Note that: p <0.05, < p <0.001 compared to model control.
In conclusion, through biological demonstration, the amazon berry jam can be considered to have the effect of promoting lead excretion for organisms, and the effect can directly and obviously promote motor nerve regeneration and improve axonal injury.
Industrial applicability
The application of the Amazonia berry or the extract thereof provided by the invention can be widely applied to industry.
Claims (5)
1. Use of amazon in the preparation of a food or health care product useful for the alleviation and amelioration of nerve damage due to lead accumulation;
the Amazon berry comprises Amazon berry fresh fruit, amazon berry dried fruit, amazon berry frozen fruit or Amazon berry pulp;
the nerve injury includes motor nerve injury and/or axonal injury.
2. The use according to claim 1, wherein the food or health product is a powdered infusible food, a baked good, a beverage, a dairy product or a pasta product.
3. The use according to claim 1, wherein the food or health product is an oral formulation.
4. The use according to claim 3, wherein the oral formulation comprises tablets, pills, granules, powders, capsules and oral liquids.
5. The use according to claim 3, wherein the oral formulation comprises a tea.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210190609.4A CN114451548B (en) | 2022-02-28 | 2022-02-28 | Application of Amazonia in preparing food or health-care product for improving nerve injury |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210190609.4A CN114451548B (en) | 2022-02-28 | 2022-02-28 | Application of Amazonia in preparing food or health-care product for improving nerve injury |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114451548A CN114451548A (en) | 2022-05-10 |
| CN114451548B true CN114451548B (en) | 2024-01-19 |
Family
ID=81416134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210190609.4A Active CN114451548B (en) | 2022-02-28 | 2022-02-28 | Application of Amazonia in preparing food or health-care product for improving nerve injury |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114451548B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040052746A (en) * | 2004-04-30 | 2004-06-23 | 김현채 | Method for producing bramble containing selenium and enzyme using the same |
| KR20150069671A (en) * | 2013-12-16 | 2015-06-24 | (주)이푸른 | Composition comprising extract of Dendropanax morbifera Lev. for the treatment and prevention of diseases caused by heavy metal poisoning |
| CN114009755A (en) * | 2021-09-29 | 2022-02-08 | 黑龙江飞鹤乳业有限公司 | Fermentation method of assai and fermentation product |
-
2022
- 2022-02-28 CN CN202210190609.4A patent/CN114451548B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20040052746A (en) * | 2004-04-30 | 2004-06-23 | 김현채 | Method for producing bramble containing selenium and enzyme using the same |
| KR20150069671A (en) * | 2013-12-16 | 2015-06-24 | (주)이푸른 | Composition comprising extract of Dendropanax morbifera Lev. for the treatment and prevention of diseases caused by heavy metal poisoning |
| CN114009755A (en) * | 2021-09-29 | 2022-02-08 | 黑龙江飞鹤乳业有限公司 | Fermentation method of assai and fermentation product |
Non-Patent Citations (3)
| Title |
|---|
| "超级水果"阿萨伊;李明;农产品市场周刊(第28期);第1页 * |
| 蒋文，等.无机化学.中国医药科技出版社,2021,(第4版),第170页. * |
| 裴胜.中医师教你宝宝常见病怎么防怎么调.吉林科学技术出版社,2018,(第1版),第233页. * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114451548A (en) | 2022-05-10 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CA2715261C (en) | Food products containing omega-3 fatty acids | |
| US7691388B2 (en) | Compositions comprising Porphyra and methods of making and using thereof | |
| US11564952B2 (en) | Water-soluble and water-insoluble propolis products with high antioxidant capacity and their production methods | |
| CN108835262B (en) | Modified milk powder for improving memory and preparation method thereof | |
| CN103989165B (en) | A kind of thorn pears vitamin complex C sheet and its preparation method | |
| WO2005096840A1 (en) | Kiwifruit extracts and extraction methods | |
| KR20120097516A (en) | Hyperlipemia-ameliorating agent, anemia-ameliorating composition, uric-acid-level-reducing composition, and foods and beverages | |
| Mostolizadeh et al. | Effects of incorporation Spirulina platensis (Gomont, 1892) powder in wheat flour on chemical, microbial and sensory properties of pasta | |
| KR20170060198A (en) | Sunsik product using fermented rice bran products and manufacturing method thereby | |
| RU2329658C1 (en) | Product "cedar proteins" from cedar nut cake | |
| CN108601372A (en) | The effective anti-oxidant compositions of collaboration for pet | |
| CN103710237A (en) | Bee product wine and preparation method thereof | |
| JP2015231975A (en) | Fucoxanthin extracted from microalga | |
| KR101837158B1 (en) | Meat sauce using fermented rice bran products and manufacturing method thereby | |
| CN114451548B (en) | Application of Amazonia in preparing food or health-care product for improving nerve injury | |
| US9737583B2 (en) | Composition for prevention or treatment of acute renal failure including herbal extract or fraction thereof as active ingredient | |
| JP5095893B2 (en) | Active oxygen scavenger | |
| CN105054062A (en) | Horseradish tree leaf cold noodles and making technology thereof | |
| CN104783159A (en) | Nutrient enhancer for middle-aged goat milk powder and preparation method thereof | |
| CN114504086A (en) | Application of amazon berry | |
| RU2161000C1 (en) | Food product | |
| KR20200129841A (en) | Food Composition Comprising Extract of Seaweed as Active Ingredient for Reducing Lead Concentration In Blood | |
| KR20040081534A (en) | Method for manufacturing the health food | |
| RU2579215C1 (en) | Dry mixture for beverage preparation | |
| DADALI et al. | Bee Bread And Bee Pollen |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |