CN114450282A - 半乳糖凝集素的新型半乳糖苷抑制剂 - Google Patents

半乳糖凝集素的新型半乳糖苷抑制剂 Download PDF

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Publication number
CN114450282A
CN114450282A CN202080062566.0A CN202080062566A CN114450282A CN 114450282 A CN114450282 A CN 114450282A CN 202080062566 A CN202080062566 A CN 202080062566A CN 114450282 A CN114450282 A CN 114450282A
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triazol
alkyl
methyl
optionally substituted
deoxy
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F·塞特贝里
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Galecto Biotech AB
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Galecto Biotech AB
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    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/056—Triazole or tetrazole radicals
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
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  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
CN202080062566.0A 2019-07-05 2020-07-03 半乳糖凝集素的新型半乳糖苷抑制剂 Pending CN114450282A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19184577 2019-07-05
EP19184577.5 2019-07-05
PCT/EP2020/068834 WO2021004940A1 (en) 2019-07-05 2020-07-03 Novel galactoside inhibitor of galectins

Publications (1)

Publication Number Publication Date
CN114450282A true CN114450282A (zh) 2022-05-06

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CN202080062566.0A Pending CN114450282A (zh) 2019-07-05 2020-07-03 半乳糖凝集素的新型半乳糖苷抑制剂

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US (1) US12441755B2 (https=)
EP (1) EP3994135A1 (https=)
JP (1) JP2022538312A (https=)
CN (1) CN114450282A (https=)
CA (1) CA3143078A1 (https=)
WO (1) WO2021004940A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022508720A (ja) * 2018-10-15 2022-01-19 ガレクト バイオテック エービー ガレクチンのガラクトシド阻害剤
CN114206893A (zh) 2019-08-09 2022-03-18 爱杜西亚药品有限公司 (杂)芳基-甲基-硫代-β-D-吡喃半乳糖苷衍生物
WO2021028323A1 (en) 2019-08-09 2021-02-18 Idorsia Pharmaceuticals Ltd (2-acetamidyl)thio-beta-d-galactopyranoside derivatives
MA56883B1 (fr) 2019-08-15 2025-04-30 Idorsia Pharmaceuticals Ltd Dérivés de 2-hydroxycycloalcane-1-carbamoyle
CN114585619B (zh) 2019-08-29 2024-09-27 爱杜西亚药品有限公司 α-D-吡喃半乳糖苷衍生物
US12312362B2 (en) 2020-10-06 2025-05-27 Idorsia Pharmaceuticals Ltd Spiro derivatives of Alpha-D-galactopyranosides
EP4237419A1 (en) 2020-11-02 2023-09-06 Idorsia Pharmaceuticals Ltd Galectin-3 inhibiting 2-hydroxycycloalkane-1 -carbamoyl derivatives
CA3205493A1 (en) * 2020-12-22 2022-06-30 Galecto Biotech Ab Novel galactoside inhibitor of galectins
CN116806219A (zh) 2021-02-09 2023-09-26 爱杜西亚药品有限公司 羟基杂环烷-氨甲酰基衍生物
RS67032B1 (sr) 2021-03-03 2025-08-29 Idorsia Pharmaceuticals Ltd Alfa-d-galaktopiranozidni derivati supstituisani triazolil-metilom
EP4337694A1 (en) 2021-05-12 2024-03-20 Dana-Farber Cancer Institute, Inc. Lag3 and gal3 inhibitory agents, xbp1, cs1, and cd138 peptides, and methods of use thereof
WO2023118267A1 (en) * 2021-12-22 2023-06-29 Galecto Biotech Ab Novel galactoside inhibitor of galectins

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107406478A (zh) * 2015-01-30 2017-11-28 格莱克特生物技术公司 半乳糖凝集素的α‑D‑半乳糖苷抑制剂
WO2019067702A1 (en) * 2017-09-27 2019-04-04 Bristol-Myers Squibb Company INHIBITORS WITH SMALL MOLECULES OF GALECTIN-3
WO2019075045A1 (en) * 2017-10-11 2019-04-18 Bristol-Myers Squibb Company INHIBITORS WITH SMALL MOLECULES OF GALECTIN-3

Family Cites Families (6)

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Publication number Priority date Publication date Assignee Title
US6849607B2 (en) 2001-05-09 2005-02-01 Health Research, Inc. Galectin recognized photosensitizers for photodynamic therapy
SE0401301D0 (sv) 2004-05-21 2004-05-21 Forskarpatent I Syd Ab Novel 3-triazolyl-galactoside inhibitors of galectins
SE0401300D0 (sv) 2004-05-21 2004-05-21 Forskarpatent I Syd Ab Novel Galactoside Inhibitors of Galectins
ES2652488T3 (es) 2009-04-28 2018-02-02 Galecto Biotech Ab Nuevos inhibidores de galactósidos de galectinas
DK2906227T3 (en) 2012-10-10 2018-12-10 Galectin Therapeutics Inc GALACTOSE-CONTAINING CARBOHYDRATE COMPOUNDS FOR THE TREATMENT OF DIABETIC Nephropathy
CN104755088A (zh) 2012-10-31 2015-07-01 格莱克特生物技术公司 半乳凝集素-3的半乳糖苷抑制剂及其用于治疗肺纤维化的应用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107406478A (zh) * 2015-01-30 2017-11-28 格莱克特生物技术公司 半乳糖凝集素的α‑D‑半乳糖苷抑制剂
WO2019067702A1 (en) * 2017-09-27 2019-04-04 Bristol-Myers Squibb Company INHIBITORS WITH SMALL MOLECULES OF GALECTIN-3
WO2019075045A1 (en) * 2017-10-11 2019-04-18 Bristol-Myers Squibb Company INHIBITORS WITH SMALL MOLECULES OF GALECTIN-3

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US20220259251A1 (en) 2022-08-18
CA3143078A1 (en) 2021-01-14
JP2022538312A (ja) 2022-09-01
US12441755B2 (en) 2025-10-14
EP3994135A1 (en) 2022-05-11
WO2021004940A1 (en) 2021-01-14

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