CN114450271B - 用于Cbl-b抑制的脲类、氨基类和取代的杂芳基类化合物 - Google Patents

用于Cbl-b抑制的脲类、氨基类和取代的杂芳基类化合物 Download PDF

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CN114450271B
CN114450271B CN202080068222.0A CN202080068222A CN114450271B CN 114450271 B CN114450271 B CN 114450271B CN 202080068222 A CN202080068222 A CN 202080068222A CN 114450271 B CN114450271 B CN 114450271B
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CN114450271A (zh
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A·T·桑德斯
N·F·本斯
C·W·扎普夫
F·柯恩
王晨博
T·库敏斯
田中裕子
M·劳伦斯
M·卡多佐
D·维斯
J·高斯灵
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Nulex Therapeutics
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Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7600123B2 (ja) 2018-10-15 2024-12-16 ニューリックス セラピューティクス，インコーポレイテッド ユビキチンプロテオソーム経路を介してｂｔｋを分解するための二官能性化合物
WO2020167518A1 (en) 2019-02-13 2020-08-20 Nurix Therapeutics, Inc. Bifunctional compounds for degrading btk via ubiquitin proteosome pathway
EP3953346A1 (en) 2019-04-09 2022-02-16 Nurix Therapeutics, Inc. 3-substituted piperidine compounds for cbl-b inhibition, and use of a cbl-b inhibitor in combination with a cancer vaccine and/or oncolytic virus
EP3969447A1 (en) 2019-05-17 2022-03-23 Nurix Therapeutics, Inc. Cyano cyclobutyl compounds for cbl-b inhibition and uses thereof
MX2021015675A (es) 2019-06-26 2022-02-03 Nurix Therapeutics Inc Compuestos de bencil-triazol sustituidos para la inhibicion de cbl-b y otros usos de los mismos.
EP4034141A1 (en) 2019-09-24 2022-08-03 Nurix Therapeutics, Inc. Cbl inhibitors and compositions for expansion of immune cells
US11820781B2 (en) 2019-12-04 2023-11-21 Nurix Therapeutics, Inc. Bifunctional compounds for degrading BTK via ubiquitin proteosome pathway
CN115297861B (zh) * 2020-01-29 2024-07-12 福宏治疗公司 化合物及其用途
US12016860B2 (en) 2021-04-08 2024-06-25 Nurix Therapeutics, Inc. Combination therapies with Cbl-b inhibitor compounds
WO2022272248A1 (en) * 2021-06-21 2022-12-29 Nimbus Clio, Inc. Cbl-b modulators and uses thereof
CN113577265B (zh) * 2021-08-04 2022-04-15 明济生物制药（北京）有限公司 Til细胞及其制备方法以及在癌症治疗中的用途
AU2022379494A1 (en) 2021-10-26 2024-05-30 Nurix Therapeutics, Inc. Piperidinylpyrazine-carboxamide compounds for treating and preventing cancer and for degrading btk
JP2024542117A (ja) 2021-11-05 2024-11-13 ジェネンテック， インコーポレイテッド Ｃ－ｃｂｌに対して選択的なｃｂｌ－ｂ阻害剤としてのラクタム
TW202342013A (zh) * 2022-02-10 2023-11-01 英屬開曼群島商百濟神州有限公司 雜環化合物、其組成物及用其進行治療之方法
WO2023205180A1 (en) 2022-04-19 2023-10-26 Nurix Therapeutics, Inc. Biomarkers for cbl, and compositions and methods for their use
WO2023250097A1 (en) 2022-06-22 2023-12-28 Nurix Therapeutics, Inc. Combination therapies with cbl-b inhibitor compounds and antiemetic agents
CN119998282A (zh) * 2022-07-12 2025-05-13 热点治疗公司 固体形式和使用方法
JP2025523057A (ja) * 2022-07-12 2025-07-17 ホットスポット セラピューティクス インコーポレイテッド がん処置における使用のためのｃｂｌ－ｂ阻害剤及び抗ｐｄ１／抗ｐｄ－ｌ１
EP4554570A1 (en) * 2022-07-12 2025-05-21 Hotspot Therapeutics, Inc. Treatment of cell proliferation-associated conditions using a combination of a clb-b inhibitor and an additional therapeutic agent
US20260028336A1 (en) * 2022-07-20 2026-01-29 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
JP2025525947A (ja) 2022-08-16 2025-08-07 グレンマーク ファーマシューティカルズ エルティーディー Ｃｂｌ－ｂ阻害剤としての置換ピリジノン化合物
WO2024062363A1 (en) * 2022-09-21 2024-03-28 Glenmark Pharmaceuticals Ltd Bicyclic heterocyclic compounds as cbl-b inhibitors
WO2024074977A1 (en) * 2022-10-04 2024-04-11 Pfizer Inc. Substituted 1 h-pyrazolo-pyridine and-pyrimidine compounds
WO2024131939A1 (en) * 2022-12-23 2024-06-27 Insilico Medicine Ip Limited Cbl-b inhibitors and methods of uses thereof
CN120584113A (zh) 2023-01-19 2025-09-02 广州宇繁南图生物科技有限公司 一种杂环化合物及其制备方法和应用
WO2024231852A1 (en) * 2023-05-08 2024-11-14 Glenmark Pharmaceuticals Ltd Substituted biphenyl compounds as cbl-b inhibitors
AU2024353668A1 (en) * 2023-09-28 2026-04-16 Insilico Medicine Ip Limited Cbl-b inhibitors and methods of uses thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101918544A (zh) * 2007-12-10 2010-12-15 因斯布鲁克医科大学 提高免疫反应性的方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192553A (en) 1987-11-12 1993-03-09 Biocyte Corporation Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use
US6352694B1 (en) 1994-06-03 2002-03-05 Genetics Institute, Inc. Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
HN2001000008A (es) * 2000-01-21 2003-12-11 Inc Agouron Pharmaceuticals Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo
EP1227321A1 (en) 2000-12-28 2002-07-31 Institut für Bioanalytik GmbH Reversible MHC multimer staining for functional purification of antigen-specific T cells
WO2004099388A2 (en) * 2003-03-05 2004-11-18 Proteologics, Inc. Cbl-b polypeptides, complexes and related methods
WO2004085382A1 (ja) * 2003-03-27 2004-10-07 Kirin Beer Kabushiki Kaisha 生体内リン輸送を阻害する化合物およびそれを含んでなる医薬
ES2566502T3 (es) * 2006-09-13 2016-04-13 The Trustees Of Columbia University In The City Of New York Agentes y métodos para provocar una respuesta inmune antitumoral
MX342995B (es) 2010-07-13 2016-10-21 Anthrogenesis Corp Métodos de generar células asesinas naturales.
EP2471548A1 (de) * 2010-12-28 2012-07-04 Apeiron Biologics AG siRNA gegen Cbl-b und optional IL2 und IL12 zur Verwendung in der Behandlung von Krebs
RU2763795C2 (ru) 2014-04-23 2022-01-11 Джуно Терапьютикс, Инк. Способы выделения, культивирования и генетической инженерии популяций клеток иммунной системы для адоптивной терапии
AU2015289644A1 (en) 2014-07-15 2017-02-02 Juno Therapeutics, Inc. Engineered cells for adoptive cell therapy
EP3325475B1 (en) * 2015-07-17 2020-03-18 Takeda Pharmaceutical Company Limited Oxadiazole derivatives useful as hdac inhibitors
EP3138905A1 (en) 2015-09-04 2017-03-08 Miltenyi Biotec GmbH Method for natural killer cell expansion
CN108884140B (zh) 2015-12-03 2022-10-25 朱诺治疗学股份有限公司 修饰的嵌合受体及相关组合物和方法
WO2017107907A1 (zh) 2015-12-25 2017-06-29 四川海思科制药有限公司 稠合环γ-氨基酸衍生物及其制备方法和在医药上的应用
WO2019148005A1 (en) * 2018-01-26 2019-08-01 Nurix Therapeutics, Inc. Inhibitors of cbl-b and methods of use thereof

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101918544A (zh) * 2007-12-10 2010-12-15 因斯布鲁克医科大学 提高免疫反应性的方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Abstract A206: Small-molecule Cbl-b inhibitors as novel intracellular checkpoint inhibitors for cancer immunotherapy;Christopher Riling 等;《Molecular Cancer Therapeutics》;20180101;第17卷(第11期);全文，尤其是文章摘要 *
Genetic and pharmacologic evaluation of the ubiquitin ligase CBL-B as a small-molecule, tumor immunotherapy target;Gosling J 等;《Cancer Research》;20190701;第79卷(第13期);全文，尤其是文章摘要 *

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