CN114425064A - Traditional Chinese medicine composition for treating cough and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating cough and preparation method thereof Download PDFInfo
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/31—Extraction of the material involving untreated material, e.g. fruit juice or sap obtained from fresh plants
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- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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Abstract
The invention provides a traditional Chinese medicine composition for treating cough, which is prepared from the following components in parts by weight: 450-550 parts of Laiyang pear paste, 180-220 parts of fructus akebiae extract, 240-260 parts of platycodon grandiflorum paste, 40-60 parts of menthol, 5-10 parts of lantern pericarp extract and 25-35 parts of ethanol water solution. The invention also provides a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition provided by the invention has a good treatment effect on cough.
Description
Technical Field
The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating cough and a preparation method thereof.
Background
Cough is a common respiratory symptom, which is caused by inflammation, foreign body, physical or chemical stimulation to the trachea, the bronchial mucosa or the pleura, and is characterized by closing the glottis, contracting the respiratory muscles, increasing the intrapulmonary pressure, then opening the glottis, and ejecting air in the lungs, usually accompanied by sound. Cough has the protective function of clearing foreign matters and secretions in respiratory tract, but if the cough is continuously changed from acute to chronic, great pain can be brought to patients, such as chest distress, pharynx itch, asthma and the like. For this reason, people generally use western medicines or Chinese medicines for treatment. Western medicines are generally used for symptomatic treatment of phlegm-resolving and cough-relieving medicines and have poor curative effects. According to the Chinese medical discussion, cough is caused by failure of dispersing and descending of the lung and adverse up-flow of lung qi, and has two major types of cough with external infection and internal injury. At present, western medicine mainly takes antitussives and antibiotics as main medicines, but long-term use of antibiotics can cause dysbacteriosis and drug resistance of organisms, and meanwhile, cough caused by viral infection is treated but not cured because the effect of using the antibiotics is weak. A large amount of Chinese patent medicines are developed in the aspect of traditional Chinese medicine, but the existing Chinese patent medicines have slow effect on cough caused by influenza (generally, the cough can be taken for 4-5 days to take effect), are not easy to be cured (generally, the cough can be cured within 2-3 weeks), have longer treatment period especially for the old and children, and can take effect or heal after being taken for longer time.
Disclosure of Invention
The invention aims to solve the technical problem of providing the traditional Chinese medicine composition for treating the cough, and the traditional Chinese medicine composition has a good treatment effect on the cough.
In order to solve the technical problems, the technical scheme of the invention is as follows:
a traditional Chinese medicine composition for treating cough is prepared from the following components in parts by weight: 450-550 parts of Laiyang pear paste, 180-220 parts of fructus akebiae extract, 240-260 parts of platycodon grandiflorum paste, 40-60 parts of menthol, 5-10 parts of lantern pericarp extract and 25-35 parts of ethanol water solution.
Further, the preparation method of the Laiyang pear syrup comprises the following steps:
peeling and removing cores of Laiyang pears, crushing and sieving with a 50-mesh sieve to obtain Laiyang pear powder, squeezing the Laiyang pear powder into pear juice by using a juicer, and vacuum-concentrating the pear juice at 60 ℃ until the relative density is 1.5-1.8 to obtain the Laiyang pear paste.
Further, the preparation method of the mother paste comprises the following steps:
pulverizing rhizoma anemarrhenae, sieving with a 50-mesh sieve to obtain rhizoma anemarrhenae powder, decocting rhizoma anemarrhenae powder in water for 3 times, wherein the weight of water added for each time is 10 times that of the rhizoma anemarrhenae powder, mixing decoctions, filtering to obtain filtrate, and vacuum concentrating the filtrate at 60 deg.C to relative density of 1.5-1.8 to obtain the final product.
Further, the preparation method of the platycodon root paste comprises the following steps:
pulverizing radix Platycodi, sieving with 50 mesh sieve to obtain radix Platycodi powder, decocting in water for 3 times, each time adding water 12 times of the weight of radix Platycodi powder, mixing decoctions, filtering to obtain filtrate, and vacuum concentrating the filtrate at 60 deg.C to relative density of 1.5-1.8 to obtain radix Platycodi paste.
Further, the lantern peel extract is prepared by the following steps:
washing pericarp of a lantern fruit with water for 2 minutes, airing to obtain dry pericarp of the lantern fruit, mixing the dry pericarp of the lantern fruit with malic acid to obtain a mixed solution, leaching the mixed solution for 1.5 hours at 70 ℃ to obtain an extracting solution, leaching the extracting solution to obtain a leaching solution, concentrating the leaching solution, precipitating with absolute ethanol to obtain a precipitate, and drying the precipitate at 50 ℃ to obtain the lantern pericarp extract.
Furthermore, in the preparation step of the lantern fruit peel extract, the ratio of the dried lantern fruit peel to malic acid is 1:25g/mL, and the volume of the concentrated suction filtration liquid and absolute ethyl alcohol is 1: 1.5.
Further, the volume concentration of ethanol in the ethanol aqueous solution is 95%.
The invention also provides a preparation method of the traditional Chinese medicine composition for treating cough.
In order to solve the technical problems, the technical scheme is as follows:
a preparation method of a traditional Chinese medicine composition for treating cough comprises the following steps:
weighing the components according to the parts by weight, adding the Laiyang pear syrup, the zhi mu cream, the platycodon root paste, the menthol and the lantern peel extract into an ethanol water solution, stirring until the mixture is uniformly mixed to obtain a mixture, granulating the mixture by using a granulator, drying the granules by using a constant-temperature air-blast drying oven, crushing, and sieving by using a 100-mesh sieve to obtain the traditional Chinese medicine composition for treating cough.
Furthermore, the drying temperature of the invention is 55-65 ℃.
Compared with the prior art, the invention has the following beneficial effects:
(1) the Laiyang pear paste used by the invention is sweet in taste, slightly sour, cold in nature and nontoxic, and has the effects of relieving cough, moistening lung, cooling heart, diminishing inflammation, reducing internal heat, relieving sore toxicity and relieving throat irritation.
(2) The Zhimu ointment used in the invention is bitter and cold in nature, enters lung, kidney and stomach meridians, has the effects of clearing lung fire, nourishing yin and moistening lung, and has better curative effects on lung heat cough, yin deficiency dry cough and thick phlegm.
(3) The platycodon root paste used in the invention is pungent, has the effects of dispersing pathogenic wind, relieving sore throat, eliminating phlegm and expelling pus, and has better curative effects on aphonia, cough with excessive phlegm, pharyngalgia, pyocutaneous disease, and the like.
(2) The lantern fruit peel extract is prepared by extracting the pericarp of the lantern fruit, contains a plurality of beneficial components, can effectively improve the stability of the traditional Chinese medicine composition, and can effectively relieve the damage of cold-natured Laiyang pear paste, Zhimu paste and platycodon root paste to intestines and stomach.
Detailed Description
The present invention will be described in detail with reference to specific embodiments, and the exemplary embodiments and descriptions thereof herein are provided to explain the present invention but not to limit the present invention.
Example 1
The traditional Chinese medicine composition for treating cough is prepared from the following components in parts by weight: 500 parts of Laiyang pear paste, 200 parts of rhizoma anemarrhenae paste, 250 parts of platycodon root paste, 50 parts of menthol, 8 parts of lantern fruit peel extract, 30 parts of ethanol water solution, and the volume concentration of ethanol in the ethanol water solution is 95%.
The preparation method of the Laiyang pear syrup comprises the following steps:
peeling and removing cores of Laiyang pears, crushing and sieving with a 50-mesh sieve to obtain Laiyang pear powder, squeezing the Laiyang pear powder into pear juice by using a juicer, and vacuum-concentrating the pear juice at 60 ℃ until the relative density is 1.5-1.8 to obtain the Laiyang pear paste.
The preparation method of the mother paste comprises the following steps:
pulverizing rhizoma anemarrhenae, sieving with a 50-mesh sieve to obtain rhizoma anemarrhenae powder, decocting rhizoma anemarrhenae powder in water for 3 times, wherein the weight of water added for each time is 10 times that of the rhizoma anemarrhenae powder, mixing decoctions, filtering to obtain filtrate, and vacuum concentrating the filtrate at 60 deg.C to relative density of 1.5-1.8 to obtain the final product.
The preparation method of the platycodon root paste comprises the following steps:
pulverizing radix Platycodi, sieving with 50 mesh sieve to obtain radix Platycodi powder, decocting in water for 3 times, each time adding water 12 times of the weight of radix Platycodi powder, mixing decoctions, filtering to obtain filtrate, and vacuum concentrating the filtrate at 60 deg.C to relative density of 1.5-1.8 to obtain radix Platycodi paste.
The lantern peel extract is prepared by the following steps:
washing pericarp of a lantern fruit with water for 2 minutes, airing to obtain dry pericarp of the lantern fruit, mixing the dry pericarp of the lantern fruit with malic acid in a ratio of 1:25g/mL to obtain a mixed solution, leaching the mixed solution at 70 ℃ for 1.5 hours to obtain an extracting solution, carrying out suction filtration on the extracting solution to obtain a filtrate, concentrating the suction filtration solution, precipitating with 1.5 times of volume of absolute ethyl alcohol to obtain a precipitate, and drying the precipitate at 50 ℃ to obtain the lantern pericarp extract.
The preparation method of the traditional Chinese medicine composition for treating cough comprises the following steps:
weighing the components according to the parts by weight, adding the Laiyang pear syrup, the zhi mu cream, the platycodon root paste, the menthol and the lantern peel extract into an ethanol water solution, stirring until the mixture is uniformly mixed to obtain a mixture, granulating the mixture by using a granulator, drying the granules by using a constant-temperature air-blast drying oven at 60 ℃, crushing, and sieving by using a 100-mesh sieve to obtain the traditional Chinese medicine composition for treating cough.
Example 2
The traditional Chinese medicine composition for treating cough is prepared from the following components in parts by weight: 450 parts of Laiyang pear syrup, 180 parts of fructus akebiae syrup, 240 parts of platycodon grandiflorum syrup, 40 parts of menthol, 5 parts of lantern peel extract and 25 parts of ethanol water solution, wherein the volume concentration of ethanol in the ethanol water solution is 95%.
The preparation steps of the Laiyang pear paste, the Zhimu paste, the platycodon root paste and the lantern fruit peel extract are the same as those in the example 1.
The preparation method of the traditional Chinese medicine composition for treating cough comprises the following steps:
weighing the components according to the parts by weight, adding the Laiyang pear syrup, the zhi mu cream, the platycodon root paste, the menthol and the lantern peel extract into an ethanol water solution, stirring until the mixture is uniformly mixed to obtain a mixture, granulating the mixture by using a granulator, drying the granules at the temperature of 55 ℃ by using a constant-temperature air-blast drying oven, crushing, and sieving by using a 100-mesh sieve to obtain the traditional Chinese medicine composition for treating cough.
Example 3
The traditional Chinese medicine composition for treating cough is prepared from the following components in parts by weight: 550 parts of Laiyang pear paste, 220 parts of rhizoma anemarrhenae paste, 260 parts of platycodon grandiflorum paste, 60 parts of menthol, 10 parts of lantern peel extract, 35 parts of ethanol water solution, and the volume concentration of ethanol in the ethanol water solution is 95%.
The preparation steps of the Laiyang pear paste, the Zhimu paste, the platycodon root paste and the lantern fruit peel extract are the same as those in the example 1.
The preparation method of the traditional Chinese medicine composition for treating cough comprises the following steps:
weighing the components according to the parts by weight, adding the Laiyang pear syrup, the zhi mu cream, the platycodon root paste, the menthol and the lantern peel extract into an ethanol water solution, stirring until the mixture is uniformly mixed to obtain a mixture, granulating the mixture by using a granulator, drying the granules by using a constant-temperature air-blast drying oven at 65 ℃, crushing, and sieving by using a 100-mesh sieve to obtain the traditional Chinese medicine composition for treating cough.
Example 4
The traditional Chinese medicine composition for treating cough is prepared from the following components in parts by weight: 480 parts of Laiyang pear paste, 210 parts of rhizoma anemarrhenae paste, 245 parts of platycodon root paste, 45 parts of menthol, 9 parts of lantern fruit peel extract, 32 parts of ethanol water solution, wherein the volume concentration of ethanol in the ethanol water solution is 95%.
The preparation steps of the Laiyang pear paste, the Zhimu paste, the platycodon root paste and the lantern fruit peel extract are the same as those in the example 1.
The preparation method of the traditional Chinese medicine composition for treating cough comprises the following steps:
weighing the components according to the parts by weight, adding the Laiyang pear syrup, the zhi mu cream, the platycodon root paste, the menthol and the lantern peel extract into an ethanol water solution, stirring until the mixture is uniformly mixed to obtain a mixture, granulating the mixture by using a granulator, drying the granules by using a constant-temperature air-blast drying oven at 60 ℃, crushing, and sieving by using a 100-mesh sieve to obtain the traditional Chinese medicine composition for treating cough.
Comparative example 1
Except for the difference from example 1 that the extract of the pericarp of lantern was not included in the composition, the preparation step of the extract of the pericarp of lantern was omitted.
Comparative example 2
Dextromethorphan hydrobromide tablet, approved as the national standard H31020361, produced by Shanghai New Yao Min Co., Ltd, with a specification of 15mg × 24 tablets.
The first test example: test for efficacy in treating cough
The test method comprises the following steps: selecting 105 cough patients with age of 20-68 years and disease course of 2-10 months, randomly and averagely dividing into 3 groups, wherein the 1 st group is a test group, treating with the drug of example 1 for 3 times a day, and taking 10g of hot water and 10 times of hot water every time; group 2 was control group 1, treated with comparative example 1 3 times daily, each time with 10g of hot water added by 10 times; group 3 was control group 2, treated with comparative example 2 3 times daily, 1 tablet each time, and swallowed with warm water. The patient's efficacy was recorded after 10 days.
The scoring method of the curative effect comprises the following steps: scoring the symptom signs of the patient, including cough, pharyngalgia and chest distress signs, wherein each score is 0, 1, 2 and 3 according to nothing, light, medium and heavy, the total score is 9, the higher the score is, the heavier the disease condition is, scoring the symptoms of the patient before and after treatment respectively, and calculating the score change rate: score change rate ═ (pre-treatment score-post-treatment score)/pre-treatment score × 100%. The score change rate is more than or equal to 70 percent and is marked as effective, the score change rate is between 30 and 70 percent and is marked as ineffective, and the score change rate is less than 30 percent and is marked as ineffective. The total effective rate of each group of patients is calculated: the total effective rate is (number of effective patients + number of effective patients)/35 × 100%.
On the other hand, the condition that the gastrointestinal discomfort of each group of patients occurs at the end of the test is counted, and the gastrointestinal discomfort rate of each group of patients is calculated: the rate of gastrointestinal discomfort is 35 x 100% of patients with gastrointestinal discomfort.
The test results are shown in table 1:
| total effective rate (%) | Gastrointestinal discomfort rate (%) | |
| Test group | 94.29 | 2.86 |
| Control group 1 | 91.43 | 28.57 |
| Control group 2 | 80 | 45.71 |
TABLE 1
Table 1 shows that the total effective rate of the test group is significantly higher than that of the control group 2, indicating that the effect of the present invention for treating cough is very good. The gastrointestinal discomfort rate of the test group is obviously lower than that of the control group 1 and the control group 2, and the result shows that the lantern peel extract used in the invention can effectively relieve the damage of cold-natured Laiyang pear paste, Zhimu paste and platycodon root paste to the intestines and the stomach.
Experiment example two: stability test
The test method comprises the following steps: stability experiments are carried out on the samples 1-4 and the comparative sample 1, the temperature is 40 +/-2 ℃, the relative humidity is 75 +/-5%, the experiment time is 9 months, the timosaponin B II content of the samples 1-4 and the comparative sample 1 before and after the experiments is measured by an HPLC detection method, and the timosaponin B II content retention rate is calculated, wherein the timosaponin B II content retention rate is the timosaponin B II content after the experiments/the timosaponin B II content before the experiments is multiplied by 100%.
The higher the retention rate of timosaponin B II content is, the better the stability is, and the test results are shown in Table 3:
| timosaponin BII content conservation ratio (%) | |
| Example 1 | 98.8 |
| Example 2 | 98.7 |
| Example 3 | 98.4 |
| Example 4 | 98.6 |
| Comparative example 1 | 92.5 |
TABLE 2
Table 2 shows that the content retention rate of timosaponin BII in examples 1 to 4 of the invention is obviously higher than that in comparative example 1, which indicates that the invention has better stability, and the lantern peel extract used in the invention can effectively improve the stability.
The above-described embodiments are merely illustrative of the principles and capabilities of the present invention and are not intended to be limiting. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (9)
1. A traditional Chinese medicine composition for treating cough is characterized in that: the traditional Chinese medicine composition is prepared from the following components in parts by weight: 450-550 parts of Laiyang pear paste, 180-220 parts of fructus akebiae extract, 240-260 parts of platycodon grandiflorum paste, 40-60 parts of menthol, 5-10 parts of lantern pericarp extract and 25-35 parts of ethanol water solution.
2. The traditional Chinese medicine composition for treating cough according to claim 1, wherein the traditional Chinese medicine composition comprises: the preparation method of the Laiyang pear syrup comprises the following steps:
peeling and removing cores of Laiyang pears, crushing and sieving with a 50-mesh sieve to obtain Laiyang pear powder, squeezing the Laiyang pear powder into pear juice by using a juicer, and vacuum-concentrating the pear juice at 60 ℃ until the relative density is 1.5-1.8 to obtain the Laiyang pear paste.
3. The traditional Chinese medicine composition for treating cough according to claim 1, wherein the traditional Chinese medicine composition comprises: the preparation method of the Zhimu ointment comprises the following steps:
pulverizing rhizoma anemarrhenae, sieving with a 50-mesh sieve to obtain rhizoma anemarrhenae powder, decocting rhizoma anemarrhenae powder in water for 3 times, wherein the weight of water added for each time is 10 times that of the rhizoma anemarrhenae powder, mixing decoctions, filtering to obtain filtrate, and vacuum concentrating the filtrate at 60 deg.C to relative density of 1.5-1.8 to obtain the final product.
4. The traditional Chinese medicine composition for treating cough according to claim 1, wherein the traditional Chinese medicine composition comprises: the preparation method of the platycodon root paste comprises the following steps:
pulverizing radix Platycodi, sieving with 50 mesh sieve to obtain radix Platycodi powder, decocting in water for 3 times, each time adding water 12 times of the weight of radix Platycodi powder, mixing decoctions, filtering to obtain filtrate, and vacuum concentrating the filtrate at 60 deg.C to relative density of 1.5-1.8 to obtain radix Platycodi paste.
5. The traditional Chinese medicine composition for treating cough according to claim 1, wherein the traditional Chinese medicine composition comprises: the lantern peel extract is prepared by the following steps:
washing pericarp of a lantern fruit with water for 2 minutes, airing to obtain dry pericarp of the lantern fruit, mixing the dry pericarp of the lantern fruit with malic acid to obtain a mixed solution, leaching the mixed solution for 1.5 hours at 70 ℃ to obtain an extracting solution, leaching the extracting solution to obtain a leaching solution, concentrating the leaching solution, precipitating with absolute ethanol to obtain a precipitate, and drying the precipitate at 50 ℃ to obtain the lantern pericarp extract.
6. The traditional Chinese medicine composition for treating cough according to claim 5, wherein the traditional Chinese medicine composition comprises: in the preparation step of the lantern fruit peel extract, the ratio of the dried lantern fruit peel to malic acid is 1:25g/mL, and the volume of the concentrated suction filtration liquid and absolute ethyl alcohol is 1: 1.5.
7. The traditional Chinese medicine composition for treating cough according to claim 1, wherein the traditional Chinese medicine composition comprises: the volume concentration of ethanol in the ethanol water solution is 95%.
8. The preparation method of the traditional Chinese medicine composition for treating cough according to any one of claims 1 to 7, which is characterized by comprising the following steps: the method comprises the following steps:
weighing the components according to the parts by weight, adding the Laiyang pear syrup, the zhi mu cream, the platycodon root paste, the menthol and the lantern peel extract into an ethanol water solution, stirring until the mixture is uniformly mixed to obtain a mixture, granulating the mixture by using a granulator, drying the granules by using a constant-temperature air-blast drying oven, crushing, and sieving by using a 100-mesh sieve to obtain the traditional Chinese medicine composition for treating cough.
9. The preparation method of the traditional Chinese medicine composition for treating cough according to claim 8, characterized in that: the drying temperature is 55-65 ℃.
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| 关海宁等: "响应面法对红菇娘皮,玉米须复合保健饮料的优化研究", 《食品工业》 * |
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