CN114425042A - Multicolor capsule shell - Google Patents
Multicolor capsule shell Download PDFInfo
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- CN114425042A CN114425042A CN202210148256.1A CN202210148256A CN114425042A CN 114425042 A CN114425042 A CN 114425042A CN 202210148256 A CN202210148256 A CN 202210148256A CN 114425042 A CN114425042 A CN 114425042A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/07—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use
- A61J3/071—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms into the form of capsules or similar small containers for oral use into the form of telescopically engaged two-piece capsules
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4816—Wall or shell material
- A61K9/4825—Proteins, e.g. gelatin
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Abstract
A multicolor capsule shell belongs to the technical field of medical hollow capsules and discloses a method for manufacturing the capsule shell, which comprises the steps of firstly preparing various color glue solutions, respectively adding gelatin, sodium dodecyl sulfate, glycerin and an opacifier into hot water for dissolving and mixing uniformly, then adding corresponding coloring agents and mixing uniformly to form coloring glue solutions, and thus preparing various color coloring agents; dipping glue in glue grooves of various colors in sequence according to different depths by using a capsule mold and drying; the hollow capsule shell has the advantages that the outer surface of the hollow capsule shell has multiple colors, so that the diversified market demands can be met, particularly, a certain specific color can be corresponding to a certain disease or a certain medicine raw material, and then the capsule shell is marked by the color, so that wrong medicines can be effectively avoided; in addition, when children refuse to take medicine, the repelling psychology can be reduced when the children see the capsules with various colors.
Description
Technical Field
The invention relates to the technical field of medical hollow capsules, in particular to a multicolor capsule shell.
Background
The hollow capsule is a packaging material of medicines, and generally comprises a capsule cap and a capsule body two-section shell, wherein the capsule body and the capsule cap are both cylindrical, the longer end is called the capsule body, the shorter end is called the capsule cap, the capsule cap and the capsule body are tightly sleeved and locked, the medicines are packaged in a capsule cavity, and the capsule is smooth in surface and uniform in color.
The existing hollow capsules are generally in the same color, or the capsule body is in one color, the capsule cap is in another color, two or more colors cannot be made on the capsule cap or the capsule body at the same time, and the diversified demands of the current market cannot be met.
Disclosure of Invention
The invention aims to solve the technical problem of providing a shell with two or more colors on a capsule cap or a capsule body simultaneously so as to meet the market diversification requirement.
In order to solve the technical problems, the invention adopts the technical scheme that the multicolor capsule shell is used for preparing a hollow capsule, the hollow capsule comprises a capsule cap and a capsule body, and the capsule shell can be the capsule cap of the hollow capsule and also can be the capsule body, and the multicolor capsule shell is characterized in that the preparation method of the capsule shell comprises the following steps:
preparing nth colored glue solution, namely adding 1000 parts of gelatin, 1.9-2.1 parts of sodium dodecyl sulfate, 5.7-6.3 parts of glycerol and 9-11 parts of opacifier by weight into 2400-2500 parts of hot water at 67-73 ℃ to dissolve for 45-60min, then uniformly mixing, adding 10+3 (n-1) ± 1 part of nth colorant, and uniformly mixing to form the nth colored glue solution; then putting the mixture into an nth glue groove, and keeping the temperature and standing for 5 to 6 hours at the temperature of between 53 and 57 ℃.
Dipping glue in an nth glue groove by using a capsule mould, wherein the glue dipping depth is the length of a shell body x (N-N + 1)/N, obtaining an nth capsule shell blank body, and drying the nth capsule shell blank body until the water content is 15% -19%.
Thirdly, dipping the dried N-1 capsule shell blank body in an N glue groove by using a capsule mold, wherein the glue dipping depth is 1/N of the length of the shell body, obtaining the N-1 capsule shell blank body containing the N-1 capsule shell blank body, and drying the N-1 capsule shell blank body until the water content is 3% -7%.
Fourthly, demolding the Nth capsule shell green body, and cutting the Nth capsule shell green body into a specified length after the quality is tested to be qualified to obtain an N-color capsule shell; wherein N is a natural number less than 10, and N is the maximum value of N, which indicates that the capsule shell has N colors.
The preparation method of the double-color capsule shell comprises the following steps:
the preparation method comprises the steps of preparing a first color glue solution, namely adding 1000 parts by weight of gelatin, 1.9-2.1 parts by weight of sodium dodecyl sulfate, 5.7-6.3 parts by weight of glycerol and 9-11 parts by weight of an opacifier into 2400-; then putting the mixture into a first glue groove, and keeping the temperature and standing for 5 to 6 hours at the temperature of between 53 and 57 ℃.
Preparing a second glue solution, namely adding 1000 parts by weight of gelatin, 1.9-2.1 parts by weight of sodium dodecyl sulfate, 5.7-6.3 parts by weight of glycerol and 9-11 parts by weight of an opacifier into 2400-2500 parts by weight of 67-73 ℃ hot water, dissolving for 45-60min, then uniformly mixing, adding 12-14 parts by weight of a second colorant, and uniformly mixing to form the second glue solution; then putting the mixture into a second glue groove, and keeping the temperature and standing for 5 to 6 hours at the temperature of between 53 and 57 ℃.
Dipping glue in the first glue groove by using a capsule mould, wherein the glue dipping depth is the length of the shell body to obtain a first capsule shell blank body, and drying the first capsule shell blank body until the water content is 15% -19%.
And dipping the dried first capsule shell blank in glue in a second glue groove by using a capsule mold, wherein the glue dipping depth is 1/2 of the length of the shell, so that a second capsule shell blank containing the first capsule shell blank is obtained, and drying the second capsule shell blank until the water content is 3% -7%.
And fifthly, demolding the second capsule shell blank, and cutting the second capsule shell blank into a specified length after the quality inspection is qualified to obtain the double-color capsule shell.
The preparation method of the three-color capsule shell comprises the following steps:
preparing first color glue solution, namely adding 1000 parts of gelatin, 1.9-2.1 parts of sodium dodecyl sulfate, 5.7-6.3 parts of glycerin and 9-11 parts of an opacifier into 2400-2500 parts of hot water at 67-73 ℃ by weight, dissolving for 45-60min, then uniformly mixing, adding 9-11 parts of a first coloring agent, and uniformly mixing to form the first color glue solution; then putting the mixture into a first glue groove, and keeping the temperature and standing for 5 to 6 hours at the temperature of between 53 and 57 ℃.
Preparing a second glue solution, namely adding 1000 parts by weight of gelatin, 1.9-2.1 parts by weight of sodium dodecyl sulfate, 5.7-6.3 parts by weight of glycerol and 9-11 parts by weight of an opacifier into 2400-2500 parts by weight of 67-73 ℃ hot water, dissolving for 45-60min, then uniformly mixing, adding 12-14 parts by weight of a second colorant, and uniformly mixing to form the second glue solution; then putting the mixture into a second glue groove, and keeping the temperature and standing for 5 to 6 hours at the temperature of between 53 and 57 ℃.
Preparing a third colloidal liquid, namely adding 1000 parts by weight of gelatin, 1.9-2.1 parts by weight of sodium dodecyl sulfate, 5.7-6.3 parts by weight of glycerol and 9-11 parts by weight of an opacifier into 2400-2500 parts by weight of hot water at 67-73 ℃ for dissolving for 45-60min, then uniformly mixing, adding 15-17 parts by weight of a third colorant, and uniformly mixing to form a third colloidal liquid; then putting the mixture into a third glue groove, and keeping the temperature and standing for 5 to 6 hours at the temperature of between 53 and 57 ℃.
Dipping glue in a first glue groove by using a capsule mould, wherein the glue dipping depth is the length of a shell to obtain a first capsule shell blank, and drying the first capsule shell blank until the water content is 15% -19%; the shell length herein refers to the overall shell length of the capsule cap or body.
Fifthly, dipping the dried first capsule shell blank in glue in a second glue groove by using a capsule mold, wherein the glue dipping depth is 2/3 of the length of the shell body to obtain a second capsule shell blank containing the first capsule shell blank, and drying the second capsule shell blank until the water content is 15% -19%; the length of the shell here and below is only the overall shell length of the capsule cap or the length of the capsule body which is visible on the outside after the capsule is sleeved and combined into the hollow capsule.
Sixthly, dipping the dried second capsule shell blank in glue in a third glue groove by using a capsule mould, wherein the glue dipping depth is 1/3 of the shell length to obtain a third capsule shell blank containing the second capsule shell blank, and drying the third capsule shell blank until the water content is 3% -7%.
And demolding the third capsule shell blank, and cutting the third capsule shell blank into a specified length after the quality inspection is qualified to obtain the three-color capsule shell.
The colorant is a pharmaceutical grade pigment, and the opacifier is pharmaceutical grade titanium dioxide.
A multicolor hollow capsule comprises a capsule cap and a capsule body, wherein the capsule cap is a single-color shell, and the capsule body is a double-color shell.
A multicolor hollow capsule comprises a capsule cap and a capsule body, wherein the capsule cap is a single-color shell, and the capsule body is a three-color shell.
A multicolor hollow capsule comprises a capsule cap and a capsule body, wherein the capsule cap is a two-color shell, and the capsule body is a two-color shell.
A multicolor hollow capsule comprises a capsule cap and a capsule body, wherein the capsule cap is a two-color shell, and the capsule body is a three-color shell.
A multicolor hollow capsule comprises a capsule cap and a capsule body, wherein the capsule cap is a three-color shell, and the capsule body is a three-color shell.
The invention has the advantages that the outer surface of the hollow capsule shell has various colors, which can meet the rich and colorful market demand, in particular, a certain specific color can be corresponding to a certain disease or a certain drug material, and then the capsule shell is marked by the color, which can effectively avoid the use of wrong drugs; in addition, when children refuse to take medicine, the repelling psychology can be reduced when the children see the capsules with various colors.
Detailed Description
The present invention is further illustrated by the following examples, which are intended to illustrate the invention but not to limit it further, and should not be construed as limiting the scope of the invention.
Example 1.
The preparation method of the double-color capsule shell comprises the following steps:
preparing first color glue solution, namely adding 10kg of gelatin for capsules, 19g of sodium dodecyl sulfate, 57g of glycerol and 90g of opacifier into 24kg of hot water at the temperature of 67 ℃ to dissolve for 45min, uniformly mixing, adding 90g of first coloring agent, and uniformly mixing to form the first color glue solution; then the mixture is put into a first glue groove and kept stand for 5 hours at the temperature of 53 ℃.
Preparing a second glue solution, namely adding 10kg of gelatin for capsules, 19g of sodium dodecyl sulfate, 57g of glycerol and 90g of opacifier into 24kg of hot water with the temperature of 67 ℃ for dissolving for 45min, then uniformly mixing, adding 120g of a second colorant, and uniformly mixing to form the second glue solution; then the mixture is put into a second glue groove and kept stand for 5 hours at the temperature of 53 ℃.
Dipping glue in the first glue groove by using a capsule mould in an environment with the temperature of 49 ℃ and the relative humidity of 45%, wherein the glue dipping depth is the designed shell length to obtain a first capsule shell blank body, and then drying the first capsule shell blank body for 90min in an environment with the drying room temperature of 31 ℃ and the relative humidity of 35% until the water content is 19%.
And fourthly, dipping the dried first capsule shell green body into glue in a second glue groove by using a capsule mould in an environment with the temperature of 49 ℃ and the relative humidity of 45%, wherein the glue dipping depth is 1/2 of the length of the shell body to obtain a second capsule shell green body containing the first capsule shell green body, and then drying the second capsule shell green body for 180min in an environment with the temperature of 35 ℃ and the relative humidity of 45% in a baking room until the water content is 7%.
And fifthly, demolding the second capsule shell blank, and cutting the second capsule shell blank into a specified length after the quality inspection is qualified to obtain the double-color capsule shell.
Example 2.
The preparation method of the double-color capsule shell comprises the following steps:
preparing first color glue solution, namely adding 10kg of gelatin for capsules, 20g of sodium dodecyl sulfate, 60g of glycerol and 100g of opacifier into 24.5kg of hot water at the temperature of 70 ℃ for dissolving for 52.5min, then uniformly mixing, adding 100g of first coloring agent, and uniformly mixing to form the first color glue solution; then the mixture is put into a first glue groove and kept stand for 5.5 hours at the temperature of 55 ℃.
Preparing a second glue solution, namely adding 10kg of gelatin for capsules, 20g of sodium dodecyl sulfate, 60g of glycerin and 100g of opacifier into 24.5kg of hot water with the temperature of 70 ℃ for dissolving for 52.5min, then uniformly mixing, adding 130g of a second colorant, and uniformly mixing to form the second glue solution; then the mixture is put into a second glue groove and kept stand for 5.5 hours at the temperature of 55 ℃.
Dipping glue in a first glue groove by using a capsule mould in an environment with the temperature of 52 ℃ and the relative humidity of 50%, wherein the glue dipping depth is the designed shell length to obtain a first capsule shell blank body, and then drying the first capsule shell blank body for 120min in an environment with the drying room temperature of 33 ℃ and the relative humidity of 40% until the water content is 17%.
And fourthly, dipping the dried first capsule shell green body into glue in a second glue groove by using a capsule mould in an environment with the temperature of 52 ℃ and the relative humidity of 50%, wherein the glue dipping depth is 1/2 of the length of the shell body to obtain a second capsule shell green body containing the first capsule shell green body, and then drying the second capsule shell green body for 210min in an environment with the baking room temperature of 35 ℃ and the relative humidity of 40% until the water content is 5%.
And fifthly, demolding the second capsule shell blank, and cutting the second capsule shell blank into a specified length after the quality inspection is qualified to obtain the double-color capsule shell.
Example 3.
The preparation method of the double-color capsule shell comprises the following steps:
preparing first color glue solution, namely adding 10kg of gelatin for capsules, 21g of sodium dodecyl sulfate, 63g of glycerin and 110g of opacifier into 25kg of 73 ℃ hot water to dissolve for 60min, then uniformly mixing, adding 110g of first coloring agent, and uniformly mixing to form the first color glue solution; then the mixture is put into a first glue groove and kept stand for 6 hours at the temperature of 57 ℃.
Preparing a second glue solution, namely adding 10kg of gelatin for capsules, 21g of sodium dodecyl sulfate, 63g of glycerol and 110g of opacifier into 25kg of 73 ℃ hot water, dissolving for 60min, then uniformly mixing, adding 140g of a second colorant, and uniformly mixing to form the second glue solution; then the mixture is put into a second glue groove and kept stand for 6 hours at the temperature of 57 ℃.
Dipping glue in the first glue groove by using a capsule mould in an environment with the temperature of 55 ℃ and the relative humidity of 55%, wherein the glue dipping depth is the designed shell length to obtain a first capsule shell blank body, and then drying the first capsule shell blank body for 150min in an environment with the drying room temperature of 35 ℃ and the relative humidity of 45% until the water content is 15%.
And fourthly, dipping the dried first capsule shell green body into glue in a second glue groove by using a capsule mould in an environment with the temperature of 55 ℃ and the relative humidity of 55%, wherein the glue dipping depth is 1/2 of the length of the shell body to obtain a second capsule shell green body containing the first capsule shell green body, and then drying the second capsule shell green body for 240min in an environment with the baking room temperature of 35 ℃ and the relative humidity of 35% until the water content is 3%.
And fifthly, demolding the second capsule shell blank, and cutting the second capsule shell blank into a specified length after the quality inspection is qualified to obtain the double-color capsule shell.
Example 4.
The preparation method of the three-color capsule shell comprises the following steps:
preparing first color glue solution, namely adding 10kg of gelatin for capsules, 19g of sodium dodecyl sulfate, 57g of glycerin and 90g of opacifier into 24kg of hot water at the temperature of 67 ℃ to dissolve for 45min, then uniformly mixing, adding 90kg of first coloring agent, and uniformly mixing to form the first color glue solution; then, the mixture was put into a first glue tank, and was allowed to stand at 53 ℃ for 5 hours.
Preparing a second glue solution, namely adding 10kg of gelatin for capsules, 19g of sodium dodecyl sulfate, 57g of glycerol and 90g of opacifier into 24kg of hot water with the temperature of 67 ℃ for dissolving for 45min, then uniformly mixing, adding 120g of a second colorant, and uniformly mixing to form the second glue solution; then the mixture is put into a second glue groove and kept stand for 5 hours at the temperature of 53 ℃.
Preparing a third colloidal liquid, namely adding 10kg of gelatin, 19g of sodium dodecyl sulfate, 57g of glycerol and 90g of opacifier into 24kg of hot water with the temperature of 67 ℃ for dissolving for 45min, then uniformly mixing, adding 150g of a third colorant, and uniformly mixing to form the third colloidal liquid; then put into a third glue groove, and kept stand for 5 hours at the temperature of 53 ℃.
Dipping glue in a first glue groove by using a capsule mould in an environment with the temperature of 49 ℃ and the relative humidity of 45%, wherein the glue dipping depth is the length of the shell to obtain a first capsule shell blank, and drying the first capsule shell blank until the water content is 19%; the shell length herein refers to the overall shell length of the capsule cap or body.
Fifthly, dipping the dried first capsule shell green body in glue in a second glue groove by using a capsule mold at the temperature of 49 ℃ and the relative humidity of 45%, wherein the glue dipping depth is 2/3 of the length of the shell body, so as to obtain a second capsule shell green body containing the first capsule shell green body, and drying the second capsule shell green body until the water content is 19%; the length of the shell here and below is only the overall shell length of the capsule cap or the length of the capsule body which is visible on the outside after the capsule is sleeved and combined into the hollow capsule.
Sixthly, dipping the dried second capsule shell blank in glue in a third glue groove by using a capsule mould in an environment with the temperature of 49 ℃ and the relative humidity of 45%, wherein the glue dipping depth is 1/3 of the shell length to obtain a third capsule shell blank containing the second capsule shell blank, and drying the third capsule shell blank until the water content is 7%.
And demolding the third capsule shell blank, and cutting the third capsule shell blank into a specified length after the quality inspection is qualified to obtain the three-color capsule shell.
Example 5.
The preparation method of the three-color capsule shell comprises the following steps:
preparing first color glue solution, namely adding 10kg of gelatin for capsules, 20g of sodium dodecyl sulfate, 60g of glycerin and 100g of opacifier into 24.5kg of hot water at the temperature of 70 ℃ for dissolving for 52.5min, then uniformly mixing, adding 100kg of first coloring agent, and uniformly mixing to form the first color glue solution; then putting the mixture into a first glue groove, and keeping the temperature and standing for 5 to 6 hours at the temperature of 55 ℃.
Preparing a second glue solution, namely adding 10kg of gelatin for capsules, 20g of sodium dodecyl sulfate, 60g of glycerin and 100g of opacifier into 24.5kg of hot water with the temperature of 70 ℃ for dissolving for 52.5min, then uniformly mixing, adding 130g of a second colorant, and uniformly mixing to form the second glue solution; then the mixture is put into a second glue groove and kept stand for 5.5 hours at the temperature of 55 ℃.
Preparing a third color glue solution, namely adding 10kg of gelatin, 20g of sodium dodecyl sulfate, 60g of glycerol and 100g of opacifier into 24.5kg of hot water with the temperature of 70 ℃ for dissolving for 52.5min, then uniformly mixing, adding 160g of a third colorant, and uniformly mixing to form the third color glue solution; then the mixture is put into a third glue groove and kept stand for 5.5 hours at the temperature of 55 ℃.
Dipping glue in a first glue groove by using a capsule mould in an environment with the temperature of 52 ℃ and the relative humidity of 50%, wherein the glue dipping depth is the length of the shell to obtain a first capsule shell blank, and drying the first capsule shell blank until the water content is 17%; the shell length herein refers to the overall shell length of the capsule cap or body.
Fifthly, dipping the dried first capsule shell green body in glue in a second glue groove by using a capsule mold at the temperature of 52 ℃ and the relative humidity of 50% to obtain 2/3 the glue dipping depth of which is the length of the shell, so as to obtain a second capsule shell green body containing the first capsule shell green body, and drying the second capsule shell green body until the water content is 17%; the length of the shell here and below is only the overall shell length of the capsule cap or the length of the capsule body which is visible on the outside after the capsule is sleeved and combined into the hollow capsule.
Sixthly, dipping the dried second capsule shell blank in glue in a third glue groove by using a capsule mould in an environment with the temperature of 52 ℃ and the relative humidity of 50%, wherein the glue dipping depth is 1/3 of the shell length to obtain a third capsule shell blank containing the second capsule shell blank, and drying the third capsule shell blank until the water content is 5%.
And demolding the third capsule shell blank, and cutting the third capsule shell blank into a specified length after the quality inspection is qualified to obtain the three-color capsule shell.
Example 6.
The preparation method of the three-color capsule shell comprises the following steps:
preparing first color glue solution, namely adding 10kg of gelatin for capsules, 21g of sodium dodecyl sulfate, 63g of glycerol and 110g of a light-screening agent into 25kg of 73 ℃ hot water to dissolve for 60min, then uniformly mixing, adding 110kg of first coloring agent, and uniformly mixing to form the first color glue solution; then the mixture is put into a first glue groove and kept stand for 6 hours at the temperature of 57 ℃.
Preparing a second glue solution, namely adding 10kg of gelatin for capsules, 21g of sodium dodecyl sulfate, 63g of glycerol and 110g of opacifier into 25kg of 73 ℃ hot water, dissolving for 60min, then uniformly mixing, adding 140g of a second colorant, and uniformly mixing to form the second glue solution; then putting the mixture into a second glue groove, and keeping the temperature at 53-57 ℃ for standing for 6 hours.
Thirdly, preparing a third glue solution, namely adding 10kg of gelatin for capsules, 21g of sodium dodecyl sulfate, 63g of glycerol and 110g of opacifier into 25kg of 73 ℃ hot water for dissolving for 60min, then uniformly mixing, adding 170g of a third colorant, and uniformly mixing to form the third glue solution; then putting the mixture into a third glue groove, and keeping the temperature at 53-57 ℃ for standing for 6 hours.
Dipping glue in a first glue groove by using a capsule mould in an environment with the temperature of 55 ℃ and the relative humidity of 55%, wherein the glue dipping depth is the length of a shell to obtain a first capsule shell blank, and drying the first capsule shell blank until the water content is 15%; the shell length herein refers to the overall shell length of the capsule cap or body.
Fifthly, dipping the dried first capsule shell blank in glue in a second glue groove by using a capsule mold at the temperature of 55 ℃ and the relative humidity of 55%, wherein the glue dipping depth is 2/3 of the length of the shell body, so as to obtain a second capsule shell blank containing the first capsule shell blank, and drying the second capsule shell blank until the water content is 15%; the length of the shell here and below is only the overall shell length of the capsule cap or the length of the capsule body which is visible on the outside after the capsule is sleeved and combined into the hollow capsule.
Sixthly, dipping the dried second capsule shell blank in glue in a third glue groove by using a capsule mould in an environment with the temperature of 55 ℃ and the relative humidity of 55%, wherein the glue dipping depth is 1/3 of the shell length to obtain a third capsule shell blank containing the second capsule shell blank, and drying the third capsule shell blank until the water content is 3%.
And demolding the third capsule shell blank, and cutting the third capsule shell blank into a specified length after the quality inspection is qualified to obtain the three-color capsule shell.
Example 7.
The red and blue double-color capsule shell as a capsule body is sleeved with a conventionally manufactured single-color capsule shell as a capsule cap to prepare a red and blue hollow capsule designated for packaging cold medicines.
The red, blue and yellow capsule shell prepared by the method is used as a capsule body and is sleeved with a conventionally prepared single-color capsule shell used as a capsule cap to prepare the red, blue and yellow hollow capsule designated as the package of cough medicines.
The red and blue capsule shell as a capsule body and the yellow and green capsule shell as a capsule cap are sleeved to prepare the multicolor hollow capsule designated for packaging the hypertension drug.
The red-blue double-color capsule shell as a capsule body is sleeved with the yellow-green-purple three-color capsule shell as a capsule cap to prepare the multi-color hollow capsule designated as packaging diabetes drugs.
The prepared red, blue and yellow three-color capsule shell is used as a capsule body and sleeved with the green, cyan and purple three-color capsule shell as a capsule cap to prepare the multicolor hollow capsule appointed to package the gout drug, so that the drug can be identified quickly and confusion is avoided.
Claims (9)
1. A multicolor capsule shell which can be a cap or a body of a hollow capsule is characterized in that the preparation method of the cap or the body comprises the following steps:
preparing nth colored glue solution, namely adding 1000 parts of gelatin, 1.9-2.1 parts of sodium dodecyl sulfate, 5.7-6.3 parts of glycerol and 9-11 parts of opacifier by weight into 2400-2500 parts of hot water at 67-73 ℃ to dissolve for 45-60min, then uniformly mixing, adding 10+3 (n-1) ± 1 part of nth colorant, and uniformly mixing to form the nth colored glue solution; then putting the mixture into an nth glue groove, and keeping the temperature and standing for 5 to 6 hours at the temperature of between 53 and 57 ℃;
dipping glue in an nth glue groove by using a capsule mould, wherein the glue dipping depth is the length of a shell body x (N-N + 1)/N, obtaining an nth capsule shell blank body, and drying the nth capsule shell blank body until the water content is 15% -19%;
thirdly, dipping the dried N-1 capsule shell blank body in an N glue groove by using a capsule mold, wherein the glue dipping depth is 1/N of the length of the shell body to obtain an N capsule shell blank body containing the N-1 capsule shell blank body, and drying the N capsule shell blank body until the water content is 3% -7%;
fourthly, demolding the Nth capsule shell green body, and cutting the Nth capsule shell green body into a specified length after the quality is tested to be qualified to obtain an N-color capsule shell; wherein N and N are natural numbers, and N is the maximum value of N, which indicates that N colors exist on the capsule shell.
2. The multicolor capsule shell according to claim 1, wherein the method for preparing the bicolor capsule shell comprises the following steps:
preparing first color glue solution, namely adding 1000 parts of gelatin, 1.9-2.1 parts of sodium dodecyl sulfate, 5.7-6.3 parts of glycerin and 9-11 parts of an opacifier into 2400-2500 parts of hot water at 67-73 ℃ by weight, dissolving for 45-60min, then uniformly mixing, adding 9-11 parts of a first coloring agent, and uniformly mixing to form the first color glue solution; then putting the mixture into a first glue groove, and keeping the temperature and standing for 5 to 6 hours at the temperature of between 53 and 57 ℃;
preparing a second glue solution, namely adding 1000 parts by weight of gelatin, 1.9-2.1 parts by weight of sodium dodecyl sulfate, 5.7-6.3 parts by weight of glycerol and 9-11 parts by weight of an opacifier into 2400-2500 parts by weight of 67-73 ℃ hot water, dissolving for 45-60min, then uniformly mixing, adding 12-14 parts by weight of a second colorant, and uniformly mixing to form the second glue solution; then placing the mixture into a second glue groove, and keeping the temperature and standing for 5-6 hours at the temperature of 53-57 ℃;
dipping glue in the first glue groove by using a capsule mould, wherein the glue dipping depth is the length of the shell to obtain a first capsule shell blank body, and drying the first capsule shell blank body until the water content is 15% -19%;
dipping the dried first capsule shell green body in glue in a second glue groove by using a capsule mold, wherein the glue dipping depth is 1/2 of the length of the shell, so as to obtain a second capsule shell green body containing the first capsule shell green body, and drying the second capsule shell green body until the water content is 3% -7%;
and fifthly, demolding the second capsule shell blank, and cutting the second capsule shell blank into a specified length after the quality inspection is qualified to obtain the double-color capsule shell.
3. The multicolor capsule shell according to claim 1, wherein the preparation method of the three-color capsule shell comprises the following steps:
preparing first color glue solution, namely adding 1000 parts of gelatin, 1.9-2.1 parts of sodium dodecyl sulfate, 5.7-6.3 parts of glycerin and 9-11 parts of an opacifier into 2400-2500 parts of hot water at 67-73 ℃ by weight, dissolving for 45-60min, then uniformly mixing, adding 9-11 parts of a first coloring agent, and uniformly mixing to form the first color glue solution; then putting the mixture into a first glue groove, and keeping the temperature and standing for 5 to 6 hours at the temperature of between 53 and 57 ℃;
preparing a second glue solution, namely adding 1000 parts by weight of gelatin, 1.9-2.1 parts by weight of sodium dodecyl sulfate, 5.7-6.3 parts by weight of glycerol and 9-11 parts by weight of an opacifier into 2400-2500 parts by weight of 67-73 ℃ hot water, dissolving for 45-60min, then uniformly mixing, adding 12-14 parts by weight of a second colorant, and uniformly mixing to form the second glue solution; then placing the mixture into a second glue groove, and keeping the temperature at 53-57 ℃ and standing for 5-6 hours;
preparing a third colloidal liquid, namely adding 1000 parts by weight of gelatin, 1.9-2.1 parts by weight of sodium dodecyl sulfate, 5.7-6.3 parts by weight of glycerol and 9-11 parts by weight of an opacifier into 2400-2500 parts by weight of hot water at 67-73 ℃ for dissolving for 45-60min, then uniformly mixing, adding 15-17 parts by weight of a third colorant, and uniformly mixing to form a third colloidal liquid; then putting the mixture into a third glue groove, and keeping the temperature and standing for 5 to 6 hours at the temperature of between 53 and 57 ℃;
dipping glue in a first glue groove by using a capsule mould, wherein the glue dipping depth is the length of a shell to obtain a first capsule shell blank, and drying the first capsule shell blank until the water content is 15% -19%;
fifthly, dipping the dried first capsule shell blank in glue in a second glue groove by using a capsule mold, wherein the glue dipping depth is 2/3 of the length of the shell body to obtain a second capsule shell blank containing the first capsule shell blank, and drying the second capsule shell blank until the water content is 15% -19%;
sixthly, dipping the dried second capsule shell blank in glue in a third glue groove by using a capsule mould, wherein the glue dipping depth is 1/3 of the shell length to obtain a third capsule shell blank containing the second capsule shell blank, and drying the third capsule shell blank until the water content is 3% -7%;
and demolding the third capsule shell blank, and cutting the third capsule shell blank into a specified length after the quality inspection is qualified to obtain the three-color capsule shell.
4. The multicolor capsule shell according to claims 1 to 3, characterized in that said coloring agent is a pharmaceutical grade pigment and said opacifier is pharmaceutical grade titanium dioxide.
5. The multicolor capsule shell according to claim 4, wherein the capsule cap of the hollow capsule is a single-color shell and the capsule body is a two-color shell.
6. The multicolor capsule shell according to claim 4, wherein the cap of the hollow capsule is a single-color shell and the capsule body is a three-color shell.
7. The multicolor capsule shell according to claim 4, wherein the capsule cap of the hollow capsule is a two-color shell and the capsule body is a two-color shell.
8. The multicolor capsule shell according to claim 4, wherein the cap of the hollow capsule is a two-color shell and the capsule body is a three-color shell.
9. The multicolor capsule shell according to claim 4, wherein the cap of the hollow capsule is a three-color shell and the capsule body is a three-color shell.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210148256.1A CN114425042A (en) | 2022-02-18 | 2022-02-18 | Multicolor capsule shell |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210148256.1A CN114425042A (en) | 2022-02-18 | 2022-02-18 | Multicolor capsule shell |
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| CN114425042A true CN114425042A (en) | 2022-05-03 |
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| CN202210148256.1A Pending CN114425042A (en) | 2022-02-18 | 2022-02-18 | Multicolor capsule shell |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3046605A (en) * | 1960-01-12 | 1962-07-31 | American Cyanamid Co | Manufacture of two-color and two-tone soft shell capsules |
| US6113945A (en) * | 1996-02-26 | 2000-09-05 | L. Perrigo Company | Multi-colored medicament |
| CN104013597A (en) * | 2014-06-18 | 2014-09-03 | 青海回医药研究会 | Preparation method of Muslim gelatin hollow capsule |
-
2022
- 2022-02-18 CN CN202210148256.1A patent/CN114425042A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3046605A (en) * | 1960-01-12 | 1962-07-31 | American Cyanamid Co | Manufacture of two-color and two-tone soft shell capsules |
| US6113945A (en) * | 1996-02-26 | 2000-09-05 | L. Perrigo Company | Multi-colored medicament |
| CN104013597A (en) * | 2014-06-18 | 2014-09-03 | 青海回医药研究会 | Preparation method of Muslim gelatin hollow capsule |
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