CN114397159A - Pretreatment method for drug preparation suspension content detection sample - Google Patents
Pretreatment method for drug preparation suspension content detection sample Download PDFInfo
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- CN114397159A CN114397159A CN202210054042.8A CN202210054042A CN114397159A CN 114397159 A CN114397159 A CN 114397159A CN 202210054042 A CN202210054042 A CN 202210054042A CN 114397159 A CN114397159 A CN 114397159A
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- 239000000725 suspension Substances 0.000 title claims abstract description 75
- 238000002203 pretreatment Methods 0.000 title claims abstract description 28
- 238000001514 detection method Methods 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims description 8
- 239000003814 drug Substances 0.000 title description 4
- 229940079593 drug Drugs 0.000 title description 4
- 239000003708 ampul Substances 0.000 claims abstract description 94
- 239000000825 pharmaceutical preparation Substances 0.000 claims abstract description 17
- 239000002904 solvent Substances 0.000 claims abstract description 12
- 238000005303 weighing Methods 0.000 claims abstract description 8
- 238000002156 mixing Methods 0.000 claims abstract description 7
- 238000005406 washing Methods 0.000 claims abstract description 5
- 239000003085 diluting agent Substances 0.000 claims description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 230000000712 assembly Effects 0.000 claims description 5
- 238000000429 assembly Methods 0.000 claims description 5
- 238000007865 diluting Methods 0.000 claims description 5
- 210000001503 joint Anatomy 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 2
- 238000007789 sealing Methods 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 abstract description 2
- 238000000034 method Methods 0.000 abstract 1
- 210000003811 finger Anatomy 0.000 description 5
- 210000003813 thumb Anatomy 0.000 description 5
- 230000000694 effects Effects 0.000 description 3
- 238000000605 extraction Methods 0.000 description 3
- 238000003780 insertion Methods 0.000 description 3
- 230000037431 insertion Effects 0.000 description 3
- 239000007788 liquid Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 210000004247 hand Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000006748 scratching Methods 0.000 description 1
- 230000002393 scratching effect Effects 0.000 description 1
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Sampling And Sample Adjustment (AREA)
Abstract
The application relates to the field of detection of pharmaceutical ingredients, in particular to a pretreatment method for a pharmaceutical preparation suspension content detection sample. The method comprises the following steps of S1, taking a plurality of suspension; s2, weighing all the suspensions in a balance, and recording the weight w 1; s3, opening an ampoule bottle for placing the suspension, and transferring the suspension into a volumetric flask; s4, washing the suspension remained in the ampoule bottle by using a solvent and transferring the suspension into the same volumetric flask; s5, adding a proper solvent into the volumetric flask for dissolving, uniformly mixing, and testing; s6, taking all the ampoules transferred with the suspension in the step S3, rinsing the inner walls of the ampoules, and naturally airing the ampoules; s7, weighing all the dried ampoules in the step S6 on a balance, and recording the weight w2, wherein the weight of all the suspension transferred into the volumetric flask to be measured is w1-w 2. By adopting the technical scheme, the suspension is extracted and enriched to the greatest extent possible, so that a foundation is laid for subsequent instrument analysis, and the detection accuracy is improved.
Description
Technical Field
The application relates to the field of detection of pharmaceutical ingredients, in particular to a pretreatment method for a pharmaceutical preparation suspension content detection sample.
Background
The detection of the content of the suspension of the pharmaceutical preparation generally comprises 2 parts of sample pretreatment and instrument analysis, wherein the sample pretreatment is to extract and enrich a target detection object to the maximum extent so as to ensure the accuracy of the instrument analysis and detection. The existing pretreatment method for detecting the content of the pharmaceutical preparation suspension generally has the defect of insufficient extraction of a target detection object in the pharmaceutical preparation suspension.
Disclosure of Invention
For better extraction and enrichment of the target detection object,
the application provides a pretreatment method for a drug preparation suspension content detection sample, which adopts the following technical scheme:
a pretreatment method for a sample for detecting the content of a suspension of a pharmaceutical preparation comprises the following steps
S1, taking a plurality of medicinal preparation suspensions, and separately splitting each suspension;
s2, weighing all the suspensions in a balance, and recording the weight w 1;
s3, taking the weighed suspension in the step S2, opening an ampoule bottle for placing the suspension, and transferring the suspension into a volumetric flask;
s4, washing the suspension remained in the ampoule bottle for a plurality of times by using a proper solvent in a small amount and transferring the suspension into the same volumetric flask;
s5, adding a proper solvent into the volumetric flask for dissolving, diluting the solution to a scale with a proper diluent, uniformly mixing the solution and the diluent to be measured;
s6, taking all ampoules of the transferred suspension in the step S3, rinsing the inner walls with ethanol, and naturally airing;
s7, weighing all the dried ampoules in the step S6 on a balance, and recording the weight w2, wherein the weight of all the suspension transferred into the volumetric flask to be measured is w1-w 2.
By adopting the technical scheme, the suspension is extracted and enriched to the greatest extent possible, and the condition that the weight of the suspension is detected wrongly due to residues in the ampoule bottle is reduced. Therefore, a foundation is laid for the analysis of subsequent instruments, and the detection accuracy is improved.
Optionally, in step S2, use and detect auxiliary device and open the ampoule, detect auxiliary device and include frame, rack, be used for ordering about the rack along the first driving piece of vertical direction motion and break the lid mechanism off with the fingers and thumb, be formed with the standing groove that a plurality of is used for placing the ampoule on the rack, the standing groove is the interval and sets up and forms one row, break the lid mechanism off with the fingers and thumb and include the mounting panel, along the centre gripping subassembly of standing groove array direction setting, be used for the gliding drive assembly of the relative frame of direction centre gripping subassembly, the guide way has been seted up on the mounting panel, and the guide way includes that the corresponding radian is 45 first circular arc portion, sliding connection has the guide block in the guide way, the centre gripping subassembly is installed on the guide block, the tangent line of first circular arc portion upper end sets up along the horizontal direction, the tangent line of first circular arc portion lower extreme is vertical direction setting.
Through adopting above-mentioned technical scheme, make the rack motion through first driving piece to make the ampoule move to centre gripping subassembly department, then clip all ampoule upper ends through the centre gripping subassembly. Then drive the guide block through drive assembly and slide in the guide way to make whole centre gripping subassembly along the orbit motion of first circular arc portion, accomplish the action of breaking off with the fingers and thumb, make one row of ampoule opened convenient operation. Meanwhile, no manual work is involved, so that the probability of pouring out the suspension due to shaking hands when the ampoule bottle is opened can be reduced.
Optionally, the guide groove further includes a second arc portion with a corresponding radian of 45 degrees, the upper end of the second arc portion is connected to the lower end of the first arc portion, the lower end of the second arc portion is located at the upper end of the second arc portion and is far away from one end of the first arc portion, and the detection auxiliary device further includes a collection box for collecting the cover body of the ampoule bottle; when the guide block is located at the lower end of the second arc part, the clamping assembly is in a state of clamping the ampoule bottle cover body and is located right above the collecting box.
Through adopting above-mentioned technical scheme, break off ampoule lid off with the fingers and thumb at the centre gripping subassembly after, the guide block slides to second circular arc portion lower extreme for centre gripping subassembly lower extreme towards the collecting box, and the ampoule lid is loosened to the centre gripping subassembly, makes the ampoule fall into in the collecting box. Can be more convenient collect the ampoule lid, also be difficult for scratching simultaneously operating personnel.
Optionally, the clamping assembly includes a mounting seat, two clamping plates slidably connected below the mounting seat, an elastic block installed on one inward side of the clamping plate, and a second driving member for driving the two clamping plates to approach or move away from each other, and the mounting seat is fixedly installed on the guide block.
Through adopting above-mentioned technical scheme, be close to each other through two grip blocks for the tight ampoule lid of elasticity piece clamp, simple structure, convenient operation.
Optionally, the mounting panel is the slope setting, and two mounting panels are the symmetry setting, two mounting panel lower extreme interval is greater than two mounting panel upper end interval, the mounting panel is equipped with the clutch blocks in one side inwards, the clutch blocks is located the elasticity piece top, horizontal direction sliding connection in frame is followed to the mounting panel, be equipped with in the frame and be used for ordering about the gliding third driving piece of the relative frame of mounting panel.
Through adopting above-mentioned technical scheme, before breaking off the ampoule lid off with the fingers and thumb, make the ampoule move to a certain point of lid lower part and aim at the clutch blocks earlier, then make two grip blocks be close to for the clutch blocks butt in the ampoule. The mounting plate is driven to reciprocate relative to the rack by the third driving piece, so that the friction block rubs a certain point of the cover body of the ampoule bottle. So that the cover body of the ampoule bottle can be easily broken by the subsequent clamping assembly.
Optionally, a volumetric flask for collecting suspension is further arranged between the two mounting plates, the volumetric flask comprises a collecting part and a volume fixing part, the collecting part and the volume fixing part are detachably connected, and the opening end of the collecting part is larger than that of the volume fixing part; when the fixed-volume part is connected with the collecting part, the fixed-volume part is connected with the opening end of the collecting part.
By adopting the technical scheme, the suspension is collected through the collection part when being collected, and the opening end of the collection part is larger, so that the suspension in the ampoule bottle can be poured into the ampoule bottle conveniently. After the collection is finished, the constant volume part is installed on the collection part, and therefore the accuracy of liquid volume measurement is improved.
Optionally, the constant volume portion is including being used for covering the connecting portion of establishing the closed collection portion open end and installing the constant volume pipe on connecting portion, constant volume pipe lower extreme intercommunication connecting portion, be equipped with the scale on the constant volume pipe.
Through adopting above-mentioned technical scheme, after the collection finishes, install constant volume portion on the collection portion, add suitable diluent and dilute to the scale, the mixing. The constant volume pipe cross-section is less, can make the liquid volume of surveying in the volumetric flask more accurate.
Optionally, a closing plate for closing the opening end of the collecting part is integrally arranged at the upper end of the collecting part, a through groove is formed in the closing plate corresponding to the position of the ampoule bottle, and the through groove is used for the ampoule bottle to be embedded; and a fourth driving part for driving the placing frame to rotate so that the ampoule bottle is turned upside down is arranged on the rack.
Through adopting above-mentioned technical scheme, all opened the back at the ampoule, can directly insert the collection portion through leading to the groove and establish on the ampoule for collection portion and ampoule relatively fixed. The holder is then turned upside down, and the ampoule and the collection portion are turned upside down, so that the suspension in the ampoule is poured into the ampoule
Optionally, a connecting seat is arranged between the two mounting plates, a containing groove used for clamping the volumetric flask is formed in the connecting seat, sliding blocks are arranged at two ends of the connecting seat, a circular arc-shaped sliding groove with the radian of 180 degrees is formed in the mounting plates, and the sliding blocks are connected in the sliding grooves in a sliding mode.
Through adopting above-mentioned technical scheme, slider and spout cooperation can play supplementary direction and the effect that supports for the collection portion can be more stable take place to rotate along with the ampoule and reverse.
Optionally, the sealing plate is fixedly connected with a guide sleeve, each through groove corresponds to one guide sleeve, the lower end of each guide sleeve is in butt joint with the through groove, and the inner diameter of the upper end of each guide sleeve is larger than that of the through groove.
Through adopting above-mentioned technical scheme to when making the ampoule insert logical groove, can enter into logical inslot along the inner wall of uide bushing, the uide bushing can play the effect of direction, makes the ampoule can be more smooth and easy stable insert logical inslot.
In summary, the present application includes at least one of the following beneficial technical effects:
1. the target detection object is more fully extracted and enriched;
2. the extraction process has less manual participation and low operation difficulty;
3. the efficiency of enrichment is improved.
Drawings
FIG. 1 is a schematic structural view of example 2.
FIG. 2 is a sectional view of embodiment 2.
Fig. 3 is a sectional view of embodiment 2 at the lid-snapping mechanism.
Fig. 4 is an enlarged view at a in fig. 2.
Fig. 5 is a sectional view at the lid-snapping mechanism in embodiment 2.
Fig. 6 is a schematic structural view of the volumetric flask according to example 2.
Description of reference numerals: 1. a frame; 2. placing a rack; 3. a cover breaking-off mechanism; 4. a collection box; 5. a volumetric flask; 6. an ampoule bottle; 7. a connecting assembly; 8. a first driving member; 9. a fourth drive; 10. mounting a plate; 11. a clamping assembly; 12. a drive assembly; 13. a guide groove; 14. a first arc portion; 15. a second arc portion; 16. a guide block; 17. a gear; 18. a rack; 19. a drive motor; 20. a mounting seat; 21. a clamping plate; 22. a friction block; 23. an elastic block; 24. a second driving member; 25. connecting grooves; 26. connecting blocks; 27. a screw rod; 28. a servo motor; 29. a third driving member; 30. a connecting seat; 31. a chute; 32. a slider; 33. a collecting section; 34. a capacity fixing part; 35. a closing plate; 36. a through groove; 37. a guide sleeve; 38. a connecting portion; 39. a constant volume tube; 40. a plate body; 41. inserting a block; 42. and (4) calibration.
Detailed Description
The present application is described in further detail below with reference to figures 1-6.
Example 1
The application embodiment 1 discloses a pretreatment method for a drug preparation suspension content detection sample. A pretreatment method for a sample for detecting the content of a suspension of a pharmaceutical preparation comprises the following steps
S1, taking a plurality of medicinal preparation suspensions, and separately splitting each suspension;
s2, weighing all the suspensions in a balance, and recording the weight w 1;
s3, taking the weighed suspension in the step S2, opening an ampoule bottle 6 for placing the suspension, and transferring the suspension into a volumetric flask 5;
s4, washing the residual suspension in ampoule 6 with a small amount of suitable solvent several times and transferring to the same volumetric flask 5;
s5, adding a proper solvent into the volumetric flask 5 for dissolving, diluting the solution to the scale 42 by using a proper diluent, and uniformly mixing the solution to be tested;
s6, taking all the ampoules 6 to which the suspension is transferred in the step S3, rinsing the inner walls with ethanol, and naturally drying;
s7, weighing all the dried ampoules 6 in the step S6 on a balance, and recording the weight w2, wherein the weight of all the suspension transferred into the volumetric flask 5 to be measured is w1-w 2.
Example 2
Specifically, referring to fig. 1 and 2, both sides of the placing frame 2 are provided with connecting assemblies 7, and the placing frame 2 is installed on the rack 1 through the connecting assemblies 7. The coupling assembly 7 comprises a first driver 8 and a fourth driver 9. The fourth driving member 9 is a motor and the body of the fourth driving member 9 is fixedly mounted on the frame 1. The first driving member 8 is an electric cylinder, and the first driving member 8 is disposed in a vertical direction. The output end of the fourth driving member 9 is fixedly connected to the cylinder body of the first driving member 8. The piston rod of the first driving member 8 is fixedly connected to the placing frame 2. The first driving piece 8 is used for driving the placing rack 2 to move along the vertical direction. The fourth driving part 9 is used for driving the placing frame 2 to rotate.
Referring to fig. 2 and 3, the cover severing mechanism 3 includes a mounting plate 10, a clamping assembly 11, and a driving assembly 12. The mounting plates 10 are provided with two blocks and are respectively positioned at two sides of the placing frame 2. The clamping assembly 11 is located directly over the placing frame 2, and the clamping assembly 11 is used for clamping the cover body of the ampoule bottle 6. The mounting plate 10 is provided with a guide groove 13, and the guide groove 13 comprises a first arc part 14 corresponding to the radian of 45 degrees and a second arc part 15 corresponding to the radian of 45 degrees. The tangent line of first circular arc portion 14 upper end sets up along the horizontal direction, and the tangent line of first circular arc portion 14 lower extreme is vertical direction setting. The upper end of the second arc part 15 is connected with the lower end of the first arc part 14, and the lower end of the second arc part 15 is positioned at the upper end of the second arc part 15 and is far away from one end of the first arc part 14. A guide block 16 is slidably connected in the guide groove 13. The two ends of the clamping mechanism are respectively connected with the two guide blocks 16. The mounting plate 10 has mounted thereon a drive assembly 12 for driving the sliding movement of the guide block 16 along the guide slot 13.
The rack 2 is moved by the first drive 8, so that the ampoules 6 are moved to the clamping assembly 11, and then all the ampoules 6 are clamped at the upper end by the clamping assembly 11. The driving assembly 12 drives the guide block 16 to slide in the guide slot 13, so that the whole clamping assembly 11 moves along the track of the first arc portion 14, and the snapping action is completed. After the clamping assembly 11 breaks the cover of the ampoule bottle 6 off, the guide block 16 slides to the lower end of the second arc portion 15, so that the lower end of the clamping assembly 11 faces the collection box 4, and the clamping assembly 11 loosens the cover of the ampoule bottle 6, so that the ampoule bottle 6 falls into the collection box 4 to complete collection.
Referring to fig. 2 and 4, in particular, the drive assembly 12 includes a gear 17, a rack 18, and a drive motor 19. The rack 18 is installed on the inner wall of the guide groove 13 and arranged along the track direction of the guide groove 13. The gear 17 is rotatably connected to the guide block 16 and engages with the rack 18. The driving motor 19 is fixedly mounted on the guide block 16 and is used for driving the gear 17 to rotate relative to the guide block 16. The gear 17 is rotated so that the gear 17 runs along the track of the rack 18, and finally the guide block 16 slides along the guide groove 13.
Referring to fig. 2 and 5, the clamping assembly 11 includes a mounting base 20, two clamping plates 21 slidably connected below the mounting base 20, a friction block 22 installed on an inward side of the clamping plates 21, an elastic block 23 installed on an inward side of the clamping plates 21, and a second driving member 24 for driving the two clamping plates 21 to approach or separate from each other.
Referring to fig. 5, the mounting block 20 is fixedly mounted to the guide block 16. The connecting groove 25 is opened along its length direction in the terminal surface under mount pad 20, and sliding connection has connecting block 26 in connecting groove 25. The connecting block 26 is provided with two blocks and one connecting block 26 corresponds to one clamping plate 21. The clamping plate 21 is fixedly mounted to its corresponding connecting block 26. The mounting plates 10 are obliquely arranged, the two mounting plates 10 are symmetrically arranged, and the distance between the lower ends of the two mounting plates 10 is larger than the distance between the upper ends of the two mounting plates 10. The second drive 24 comprises a screw 27 and a servo motor 28. The screw 27 passes through the two connecting blocks 26 and is rotatably connected to the mounting base 20. The screw 27 is positively threaded to one of the connecting blocks 26 and is negatively threaded to the other connecting block 26. The servo motor 28 is fixedly installed on the mounting base 20, and the servo motor 28 is used for driving the screw rod 27 to rotate. The two connecting blocks 26 can be driven to be close to or far away from each other by rotating the connecting screw rod 27, so that the distance between the two clamping plates 21 is adjusted, and the cover body of the ampoule bottle 6 is clamped and released.
Referring to fig. 1 and 5, the friction block 22 is located above the elastic block 23. The mounting plate 10 is slidably attached to the frame 1 in the direction of the arrangement of the ampoules 6. The frame 1 is provided with a third driving member 29 for driving the mounting plate 10 to slide relative to the frame 1. The third drive member 29 is a cylinder. The third driving member 29 is disposed in a horizontal direction. The cylinder of the third driving member 29 is fixedly mounted to the frame 1, and the piston rod of the third driving member 29 is fixedly connected to the mounting plate 10.
Before the cover of the ampoule bottle 6 is opened, the ampoule bottle 6 is moved to a certain point below the cover to align with the friction block 22, and then the two clamping plates 21 are closed, so that the friction block 22 abuts against the ampoule bottle 6. The mounting plate 10 is moved back and forth relative to the frame 1 by the third drive 29, so that the friction block 22 rubs against a point on the cover of the ampoule 6. So that the subsequent clamping assembly 11 can easily open the cover of the ampoule 6.
Then, the two clamping plates 21 move back to back, so that the ampoule bottle 6 moves to a certain point on the lower part of the cover body and is aligned with the elastic block 23, and finally, the two clamping plates 21 approach each other, so that the elastic block 23 clamps the cover body of the ampoule bottle 6, and preparation is made for the cover-breaking action.
Referring to fig. 2 and 3, a connecting socket 30 is provided between the mounting plates 10 for more convenient collection of the suspension in the ampoule 6. The mounting plate 10 is provided with a circular arc chute 31 with a radian of 180 degrees, and the slide block 32 is connected in the chute 31 in a sliding manner. The connecting seat 30 is provided with a holding groove for clamping the volumetric flask 5.
Referring to fig. 6, the volumetric flask 5 includes a collecting portion 33 and a holding portion 34, and the collecting portion 33 is rectangular and has an open upper end. The upper end of the collecting part 33 is integrally provided with a closing plate 35 for closing the opening end of the collecting part 33, a through groove 36 is formed in the position, corresponding to the ampoule bottle 6, of the closing plate 35, and the through groove 36 is used for embedding the ampoule bottle 6. The closing plate 35 is fixedly connected with guide sleeves 37, each through groove 36 corresponds to one guide sleeve 37, the lower ends of the guide sleeves 37 are in butt joint with the through grooves 36, and the inner diameter of the upper ends of the guide sleeves 37 is larger than that of the through grooves 36. The constant volume part 34 includes a connection part 38 for covering the through groove 36 and a constant volume pipe 39 mounted on the connection part 38. The connecting portion 38 includes a plate body 40 and an insertion block 41, the plate body 40 is covered on the upper end of the closing plate 35, and the insertion block 41 is inserted into the guide sleeve 37 so that the through groove 36 is closed. The constant volume pipe 39 is arranged along the vertical direction, the lower end of the constant fusing part is communicated with the connecting part 38, and scales 42 are arranged on the constant volume pipe 39.
Referring to fig. 2, in operation, the holding portion 34 is first removed, and the collecting portion 33 is fitted into the holding groove. The collecting section 33 is now positioned directly above the placing frame 2. The clamping assembly 11 has been moved to the side of the placing frame 2. Then the placing frame 2 is driven by the first driving piece 8 to move upwards, the open end of the ampoule bottle 6 is inserted into the collecting part 33 through the through groove 36, and the collecting part 33 and the ampoule bottle 6 are relatively fixed. The placing frame 2 is then turned upside down by the fourth driving member 9, and the ampoule bottle 6 and the collecting part 33 are also turned upside down, so that the suspension in the ampoule bottle 6 is poured into the collecting part 33, and the operation is convenient.
After the suspension has been poured, the ampoule 6 is then removed from the collection part 33 by moving the holder 2 upwards by means of the first drive element 8, and the ampoule 6 and the collection part 33 are then treated separately. Specifically, the collecting portion 33 is removed, the suspension remaining in the ampoule 6 is washed with a suitable solvent a small number of times and transferred to the collecting portion 33, and the holding portion 34 is attached to the collecting portion 33 by insertion. And then adding a proper solvent into the volumetric flask 5 for dissolving, diluting the solution to the scale 42 by using a proper diluent, and uniformly mixing the solution to be measured.
In order to allow the collecting part 33 to be more stably inserted into the receiving groove, a rubber layer for increasing friction is provided in the receiving groove. In order to make the ampoule 6 more stable to be placed in the placement groove, a rubber layer for increasing the friction force is also provided in the placement groove.
The implementation principle of the embodiment is as follows:
1. in an initial state, the clamping assembly 11 is positioned above the placing frame 2, and the connecting seat 30 provided with the collecting part 33 is positioned above the clamping assembly 11;
2. a row of ampoules 6 to be opened are placed on the placing rack 2;
3. the first driving piece 8 moves the placing frame 2, so that the ampoule bottle 6 moves between the two clamping plates 21, a certain point of the lower part of the cover body of the ampoule bottle 6 is aligned with the friction block 22, and then the two clamping plates 21 are close to enable the friction block 22 to abut against the ampoule bottle 6;
4. the mounting plate 10 is driven to reciprocate relative to the frame 1 by the third driving piece 29, so that the friction block 22 rubs a certain point on the cover body of the ampoule bottle 6;
5. the two clamping plates 21 move back to back, so that the ampoule bottle 6 moves to a certain point at the lower part of the cover body to be aligned with the elastic block 23, and the elastic block 23 clamps the cover body of the ampoule bottle 6 by the mutual approach of the two clamping plates 21;
6. the driving assembly 12 drives the guide block 16 to slide in the guide groove 13, so that the whole clamping assembly 11 moves along the track of the first arc portion 14, the breaking-off action is completed, and the cover body of the ampoule bottle 6 is broken off by the clamping assembly 11;
7. after the clamping assembly 11 breaks off the cover body of the ampoule bottle 6, the guide block 16 slides to the lower end of the second arc part 15, so that the lower end of the clamping assembly 11 faces the collecting box 4, and the clamping assembly 11 loosens the cover body of the ampoule bottle 6, so that the ampoule bottle 6 falls into the collecting box 4 to finish collection; the clamping component 11 is positioned at one side of the placing rack 2;
8. the placing frame 2 is driven by the first driving piece 8 to move upwards, and the opening end of the ampoule bottle 6 penetrates through the through groove 36 and is inserted into the collecting part 33, so that the collecting part 33 and the ampoule bottle 6 are relatively fixed;
9. the placing frame 2 is turned upside down by the fourth driving piece 9, and the ampoule bottle 6 and the collecting part 33 are also turned upside down, so that the suspension in the ampoule bottle 6 is poured into the collecting part 33;
10. after the suspension is poured, the placing frame 2 is driven to move upwards through the first driving piece 8, so that the ampoule bottle 6 is separated from the collecting part 33;
11. taking down the collecting part 33, washing the suspension remained in the ampoule bottle 6 with a proper solvent for a plurality of times, transferring the suspension into the collecting part 33, and inserting and installing the containing part 34 on the collecting part 33;
12. and (3) adding a proper solvent into the volumetric flask 5 for dissolving, diluting the solution to the scale 42 by using a proper diluent, and uniformly mixing the solution to be measured.
The above embodiments are preferred embodiments of the present application, and the protection scope of the present application is not limited by the above embodiments, so: all equivalent changes made according to the structure, shape and principle of the present application shall be covered by the protection scope of the present application.
Claims (10)
1. A pretreatment method for a sample for detecting the content of a suspension of a pharmaceutical preparation is characterized by comprising the following steps: comprises the following steps
S1, taking a plurality of medicinal preparation suspensions, and separately splitting each suspension;
s2, weighing all the suspensions in a balance, and recording the weight w 1;
s3, taking the weighed suspension in the step S2, opening an ampoule bottle (6) for placing the suspension, and transferring the suspension into a volumetric flask (5);
s4, washing the suspension remained in the ampoule bottle (6) with a proper solvent for a plurality of times in a small amount and transferring the suspension to the same volumetric flask (5);
s5, adding a proper solvent into the volumetric flask (5) for dissolving, diluting the solution to a scale (42) by using a proper diluent, and uniformly mixing the solution to be tested;
s6, taking all the ampoule bottles (6) with the transferred suspension in the step S3, rinsing the inner wall with ethanol, and naturally drying;
s7, taking all the dried ampoules (6) in the step S6, weighing the ampoules on a balance, recording the weight w2, and transferring all the suspensions transferred into the volumetric flask (5) to be measured to the weight w1-w 2.
2. The pretreatment method of a sample for detecting the suspension content of a pharmaceutical preparation according to claim 1, wherein the pretreatment method comprises the following steps: in the step S2, the ampoule bottle (6) is opened by using an auxiliary detection device, the auxiliary detection device comprises a rack (1), a placing rack (2), a first driving piece (8) for driving the placing rack (2) to move along the vertical direction and a cover breaking mechanism (3), a plurality of placing grooves for placing the ampoule bottle (6) are formed on the placing rack (2), the placing grooves are arranged at intervals and form a row, the cover breaking mechanism (3) comprises a mounting plate (10), clamping assemblies (11) arranged along the arrangement direction of the placing grooves and a driving assembly (12) for guiding the clamping assemblies (11) to slide relative to the rack (1), a guide groove (13) is formed in the mounting plate (10), the guide groove (13) comprises a first arc part (14) with the corresponding radian of 45 degrees, a guide block (16) is connected in the guide groove (13) in a sliding manner, and the clamping assemblies (11) are mounted on the guide block (16), the tangent line of first circular arc portion (14) upper end sets up along the horizontal direction, the tangent line of first circular arc portion (14) lower extreme is vertical direction setting.
3. The pretreatment method of the sample for detecting the suspension content of the pharmaceutical preparation according to claim 2, wherein the pretreatment method comprises the following steps: the guide groove (13) further comprises a second arc part (15) with a corresponding radian of 45 degrees, the upper end of the second arc part (15) is connected with the lower end of the first arc part (14), the lower end of the second arc part (15) is positioned at one end, far away from the first arc part (14), of the upper end of the second arc part (15), and the detection auxiliary device further comprises a collection box (4) for collecting the cover body of the ampoule bottle (6); when the guide block (16) is positioned at the lower end of the second arc part (15), the clamping assembly (11) is in a state of clamping the cover body of the ampoule bottle (6) and is positioned right above the collecting box (4).
4. The pretreatment method of the sample for detecting the suspension content of the pharmaceutical preparation according to claim 2, wherein the pretreatment method comprises the following steps: the clamping assembly (11) comprises a mounting seat (20), two clamping plates (21) connected below the mounting seat (20) in a sliding mode, an elastic block (23) installed on one inward side of each clamping plate (21), and a second driving piece (24) used for driving the two clamping plates (21) to be close to or far away from each other, wherein the mounting seat (20) is fixedly installed on the guide block (16).
5. The pretreatment method of the sample for detecting the suspension content of the pharmaceutical preparation, according to claim 4, wherein the pretreatment method comprises the following steps: mounting panel (10) are the slope setting, and two mounting panels (10) are the symmetry and set up, two mounting panel (10) lower extreme interval is greater than two mounting panel (10) upper end interval, mounting panel (10) one side is equipped with clutch block (22) inwards, clutch block (22) are located elastic block (23) top, horizontal direction sliding connection is followed in frame (1) mounting panel (10), be equipped with on frame (1) and be used for ordering about the gliding third driving piece (29) of relative frame (1) of mounting panel (10).
6. The pretreatment method of the sample for detecting the suspension content of the pharmaceutical preparation according to claim 2, wherein the pretreatment method comprises the following steps: a volumetric flask (5) for collecting suspension is further arranged between the two mounting plates (10), the volumetric flask (5) comprises a collecting part (33) and a constant volume part (34), the collecting part (33) and the constant volume part (34) are detachably connected, and the opening end of the collecting part (33) is larger than that of the constant volume part (34); when the holding part (34) is connected with the collecting part (33), the holding part (34) is connected with the opening end of the collecting part (33).
7. The pretreatment method of the sample for detecting the suspension content of the pharmaceutical preparation according to claim 6, wherein the pretreatment method comprises the following steps: decide appearance portion (34) including being used for the lid to establish connecting portion (38) that seal collection portion (33) open end and installing constant volume pipe (39) on connecting portion (38), constant volume pipe (39) lower extreme intercommunication connecting portion (38), be equipped with scale (42) on constant volume pipe (39).
8. The pretreatment method of a sample for detecting the suspension content of a pharmaceutical preparation according to claim 7, wherein the pretreatment method comprises the following steps: a closing plate (35) for closing the opening end of the collecting part (33) is integrally arranged at the upper end of the collecting part (33), a through groove (36) is formed in the position, corresponding to the ampoule bottle (6), of the closing plate (35), and the ampoule bottle (6) is embedded into the through groove (36); and a fourth driving part (9) for driving the placing frame (2) to rotate so as to enable the ampoule bottle (6) to be turned upside down is arranged on the rack (1).
9. The pretreatment method of a sample for detecting the suspension content of a pharmaceutical preparation according to claim 8, wherein the pretreatment method comprises the following steps: be equipped with connecting seat (30) between two mounting panels (10), offer the holding tank that is used for the card to establish volumetric flask (5) on connecting seat (30), connecting seat (30) both ends are equipped with slider (32), set up arc spout (31) that the radian is 180 on mounting panel (10), slider (32) sliding connection is in spout (31).
10. The pretreatment method of a sample for detecting the suspension content of a pharmaceutical preparation according to claim 8, wherein the pretreatment method comprises the following steps: the sealing plate (35) is fixedly connected with guide sleeves (37), each through groove (36) corresponds to one guide sleeve (37), the lower ends of the guide sleeves (37) are in butt joint with the through grooves (36), and the inner diameter of the upper ends of the guide sleeves (37) is larger than the through grooves (36).
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