CN114391921B - Multifunctional thrombus treatment device and application method thereof - Google Patents
Multifunctional thrombus treatment device and application method thereof Download PDFInfo
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- CN114391921B CN114391921B CN202210015578.9A CN202210015578A CN114391921B CN 114391921 B CN114391921 B CN 114391921B CN 202210015578 A CN202210015578 A CN 202210015578A CN 114391921 B CN114391921 B CN 114391921B
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- 208000007536 Thrombosis Diseases 0.000 title claims abstract description 287
- 238000000034 method Methods 0.000 title abstract description 29
- 238000011084 recovery Methods 0.000 claims abstract description 61
- 210000004204 blood vessel Anatomy 0.000 claims abstract description 45
- 239000003814 drug Substances 0.000 claims description 25
- 230000002537 thrombolytic effect Effects 0.000 claims description 25
- 229940079593 drug Drugs 0.000 claims description 13
- 230000000149 penetrating effect Effects 0.000 claims description 9
- 230000009424 thromboembolic effect Effects 0.000 claims 1
- 230000000694 effects Effects 0.000 description 16
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- 239000003146 anticoagulant agent Substances 0.000 description 8
- 230000002159 abnormal effect Effects 0.000 description 5
- 230000017531 blood circulation Effects 0.000 description 5
- 239000000463 material Substances 0.000 description 5
- 239000000243 solution Substances 0.000 description 5
- 230000009471 action Effects 0.000 description 4
- 210000001715 carotid artery Anatomy 0.000 description 4
- 239000003527 fibrinolytic agent Substances 0.000 description 4
- 230000006870 function Effects 0.000 description 3
- 238000002347 injection Methods 0.000 description 3
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- 229910001000 nickel titanium Inorganic materials 0.000 description 3
- 239000007921 spray Substances 0.000 description 3
- 229940126585 therapeutic drug Drugs 0.000 description 3
- 230000002792 vascular Effects 0.000 description 3
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- 208000001435 Thromboembolism Diseases 0.000 description 1
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/221—Gripping devices in the form of loops or baskets for gripping calculi or similar types of obstructions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22001—Angioplasty, e.g. PCTA
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22038—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with a guide wire
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22072—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for with an instrument channel, e.g. for replacing one instrument by the other
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22082—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance
- A61B2017/22084—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for after introduction of a substance stone- or thrombus-dissolving
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22094—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for for crossing total occlusions, i.e. piercing
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- Health & Medical Sciences (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
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- Orthopedic Medicine & Surgery (AREA)
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Abstract
The invention provides a multifunctional thrombus treatment device and a use method thereof, wherein the multifunctional thrombus treatment device comprises a guide wire, a variable-diameter thrombus taking support, a fixed catheter and a recovery catheter, wherein the density of a distal net part of the variable-diameter thrombus taking support is larger so as to realize fine thrombus which is difficult to catch, a sliding opening is arranged at the distal end of the variable-diameter thrombus taking support and sleeved outside the guide wire, the proximal end of the variable-diameter thrombus taking support is connected with the distal end of the fixed catheter, the diameter of the variable-diameter thrombus taking support can be adjusted by adjusting the positions of the guide wire and the fixed catheter, thrombus with different sizes in a blood vessel is fully captured, the recovery catheter is sleeved on the outer wall of the fixed catheter and can be used for accommodating the variable-diameter thrombus taking support, the diameter of the variable-diameter thrombus taking support can be repeatedly changed so as to capture the maximum amount, the thrombus which is larger and difficult to catch can be dissolved in advance through the fixed and the recovery catheter, and the thrombus is caught again after being small, and multiple treatment methods of thrombus dissolving, thrombus taking and net are simultaneously completed.
Description
Technical Field
The invention relates to the field of medical equipment, in particular to a multifunctional thrombus treatment device capable of simultaneously realizing thrombolysis and thrombus removal and a use method thereof.
Background
Abnormal vascular access causes abnormal blood flow within the blood vessel, which can cause a series of adverse consequences such as tissue hypoxia, abnormal pressure within the blood vessel, increased heart loading, and even heart failure, so that the abnormal access generally requires restoration or reconstruction of blood flow within the blood vessel by catheter intervention techniques.
There are also various adverse consequences associated with the stenosis or blockage of the blood vessel, such as turbulent blood flow, slow flow, and the formation of blood clots, thereby limiting the blood supply to the downstream areas of the vascular system. Stroke may be initiated when a blood clot is located in the neurovascular system; when a blood clot is located in the pulmonary vascular system, pulmonary embolism may be initiated, leading to death of the patient. In addition, an obstruction such as atherosclerosis and plaque thereof may become dangerous when it restricts blood flow, causing abnormal blood flow, and causing various vascular diseases.
Therefore, there is a need in the clinic for an effective drug, device or/and system for clearing thrombotic plaque to clear plaque obstructions in blood vessels in time, open occluded blood vessels, capture sloughed thrombotic tissue, and reduce ischemia and necrosis of distal organ tissue vessels caused by sloughed thrombus.
At present, methods such as thrombolysis, mechanical thrombolysis and the like are widely adopted to remove thrombus. Thrombolytic therapy is mainly to remove thrombus plaques by injecting thrombolytic drugs into thrombus positions through a catheter, the method is mostly used for early thromboembolism, has poor effect on large plaques and long-time hardening plaques, and percutaneous mechanical thrombus removal (percutaneous mechanical thrombectomy, PMT) is to remove intravascular obstructions by using a mechanical device, and comprises the modes of dissolving, crushing, sucking, stent or basket thrombus removal and the like, thus being the main treatment means in clinic at present.
Conventional percutaneous mechanical thrombolysis devices, one is to insert a balloon catheter into the vessel and through the clot, after which the balloon is inflated, compressing the clot against the vessel wall or into the distal vessel to open the occluded vessel. The method cannot remove the thrombus, and the biggest problem is that the crushed thrombus is detached, so that the distal blood vessel is re-embolized.
Another type of stent is one that delivers the self-expanding stent through a microcatheter to the site of the thrombus, where the stent, when expanded by release from the microcatheter, embeds the thrombus within the stent and then returns to the catheter. Compared with the balloon expansion, the method can take out thrombus, but the diameter of the stent after expansion is fixed and is disposable, if the thrombus can not be captured for the first time, the thrombus taking operation fails, on the other hand, the mesh of the stent is fixed, only the thrombus smaller than the mesh of the stent can be captured, and the thrombus larger than the mesh is basically ineffective, so that the clinical use effect is limited. In addition, because the distal stent end of this approach was developed, there was also a problem of thrombus escape.
It can be seen that the single traditional thrombus treatment method can not effectively treat thrombus problems whether thrombolysis, balloon thrombus expansion or mechanical thrombus removal. The inventors believe that in order to solve the above-mentioned problems, a clinically desirable mechanical thrombolytic device should simultaneously comprise: the invention is an innovative product integrating catheter drug thrombolysis, high-efficiency mechanical thrombus removal and thrombus escape prevention, and the mechanical thrombus removal device in the prior art lacks the functions.
Disclosure of Invention
The invention provides a multifunctional thrombus treatment device and a use method thereof, which are provided with a channel for injecting thrombolytic drugs, have strong thrombus capturing capacity and the function of preventing the escape of fallen thrombus plaques, and can effectively solve the problems of falling thrombus, poor thrombus taking effect and the like in a single thrombus treatment device.
A multifunctional thrombus treatment device according to a first aspect of the present invention comprises:
a guide wire;
the recovery catheter is sleeved on the outer wall of the guide wire, and a first accommodating cavity is formed between the inner wall of the recovery catheter and the outer wall of the guide wire;
the variable diameter thrombus taking support is of a net structure, the guide wire penetrates through the variable diameter thrombus taking support, the diameter of the variable diameter thrombus taking support is variable, the variable diameter thrombus taking support is suitable for blood vessels or thrombus with different widths by changing the diameter of the variable diameter thrombus taking support, and the first accommodating cavity is used for accommodating the variable diameter thrombus taking support and is used for conveying medicines.
According to one embodiment of the present invention, the variable diameter thrombus removal stent comprises a distal net part, a middle net part and a proximal net part which are sequentially connected, wherein the distal net part and the proximal net part are mutually closed to press the middle net part so as to enlarge the diameter of the middle net part, and the distal net part and the proximal net part are mutually separated so as to stretch the middle net part so as to reduce the diameter of the middle net part.
According to one embodiment of the invention, one end of the distal net part far away from the middle net part is provided with a sliding opening sleeved on the outer wall of the guide wire so as to be in sliding fit with the guide wire, and the sliding opening is used for approaching or moving away from the proximal net part by sliding along the axial direction of the guide wire.
According to one embodiment of the present invention, further comprising:
the fixed catheter is sleeved on the outer wall of the guide wire, the fixed catheter penetrates through the recovery catheter, the first containing cavity is arranged between the inner wall of the recovery catheter and the outer wall of the fixed catheter, and one end, far away from the middle net part, of the near-end net part is fixedly connected with one end of the fixed catheter.
According to one embodiment of the invention, the inner wall of the fixed catheter and the outer wall of the guide wire are provided with second cavities, the second cavities penetrate through two ends of the fixed catheter, one end, away from the proximal net part, of each second cavity is used for injecting medicines, and one end, close to the proximal net part, of each second cavity is used for outputting medicines.
According to one embodiment of the present invention, further comprising:
the connecting handle is provided with a guide wire channel, a first channel and a second channel, wherein the guide wire channel is used for conveying the guide wire, the first channel is used for conveying the fixed catheter, and the second channel is used for conveying the recovery catheter.
According to one embodiment of the invention, the connecting handle comprises a proximal handle and a distal handle which are detachably connected, the guide wire channel and the first channel are arranged on the proximal handle, and the second channel is arranged on the distal handle.
According to one embodiment of the invention, the distal end of the guide wire extends from the distal end of the variable diameter thrombolysis stent and is provided with a flexible tip.
According to one embodiment of the invention, the variable diameter thrombolytic stent has a density at its distal end that is greater than its proximal end.
The method for using the multifunctional thrombus treatment device provided by the second aspect of the invention comprises the following steps:
controlling the diameter of the variable-diameter thrombus taking stent to be smaller than the diameter of a blood vessel, penetrating the guide wire into the blood vessel and penetrating the guide wire through thrombus;
injecting a drug into the first lumen from an end of the first lumen near the proximal end of the guide wire, such that the drug is delivered from the distal end of the first lumen near the guide wire and acts on the thrombus to soften or break down the thrombus;
increasing the diameter of the variable diameter thrombus taking support, enabling the variable diameter thrombus taking support to pass through thrombus originally positioned on the outer side of the variable diameter thrombus taking support in the diameter increasing process, and enabling the thrombus to be contained between the inner side of the variable diameter thrombus taking support and the outer side of the guide wire after the diameter is increased, so that the thrombus is captured;
the recovery catheter is sleeved on the outer wall of the guide wire, and a first accommodating cavity is formed between the inner wall of the recovery catheter and the outer wall of the guide wire;
the variable diameter thrombus taking support is of a net structure, the guide wire penetrates through the variable diameter thrombus taking support, and the diameter of the variable diameter thrombus taking support is variable.
Specifically, the method of using the multifunctional thrombus treatment device may further comprise:
under the condition that the diameter of a blood vessel at a thrombus position is larger or a gap between the blood vessel and the wall of the blood vessel is larger, a recovery catheter containing the variable-diameter thrombus taking stent is inserted into the blood vessel and passes through thrombus tissues, the recovery catheter is retracted, and the guide wire naturally expands at the thrombus position to capture thrombus;
under the condition that the diameter of a blood vessel at a thrombus position is small and a recovery catheter cannot pass through, firstly, the recovery catheter containing the variable-diameter thrombus-taking stent is inserted into the position close to the thrombus, the variable-diameter thrombus-taking stent is fixed at the minimum diameter, then the variable-diameter thrombus-taking stent under the minimum diameter is pushed out of the recovery catheter and further passes through thrombus tissues, and the stent is opened to capture thrombus at the maximum diameter.
Increasing the diameter of the variable diameter thrombus taking support, enabling the variable diameter thrombus taking support to pass through thrombus originally positioned on the outer side of the variable diameter thrombus taking support in the diameter increasing process, and enabling the thrombus to be contained between the inner side of the variable diameter thrombus taking support and the outer side of the guide wire after the diameter is increased, so that the thrombus is captured; the diameter of the stent is repeatedly changed to capture thrombus tissue to the greatest extent.
While, before or after repeatedly changing the diameter of the stent to capture thrombus, injecting the medicine from the proximal end of the first, second or/and third cavity, and flowing out near or in the thrombus tissue at the distal end of the first, second or/and third cavity so as to soften or decompose thrombus and increase the effect of capturing thrombus by the stent.
And the variable-diameter thrombus taking support is accommodated in the first accommodating cavity of the recovery catheter and leaves the blood vessel along with the recovery catheter.
The embodiment of the invention has the following beneficial effects:
on the one hand, in the multifunctional thrombus treatment device of this embodiment, by setting the diameter-variable thrombus taking stent with adjustable self diameter, the self diameter is adjusted according to the blood vessels of different sizes, so as to smoothly move in the blood vessels of different sizes, and the self diameter can be increased according to the size of the thrombus until the thrombus is abutted, so as to capture the thrombus of different sizes in the blood vessels.
On the other hand, through setting up the recovery pipe that forms first appearance chamber with the guide wire between, the accessible is to the mode of first appearance chamber medicine injection, realize dissolving thrombus, or decompose into a plurality of thrombus that can be caught by the thrombus taking support body of great volume less volume, or soften thrombus, the thrombus after softening is more easily by the variable diameter thrombus taking support extrusion cutting that is in diameter increase in-process, further improved the effect that variable diameter thrombus taking support caught thrombus, simultaneously, the variable diameter thrombus taking support after accomplishing the thrombus and catching can be held in first appearance intracavity through the mode that makes self diameter reduce, follow recovery pipe together leave the blood vessel afterwards, recovery pipe plays the parcel effect to the thrombus in the variable diameter thrombus taking support, avoid the thrombus to take place the condition of breaking away from and escaping at the in-process that variable diameter thrombus taking support left the blood vessel and block up other branch blood vessels, and is simple in structure.
On the other hand, on the basis of the variable diameter thrombus taking support of the embodiment, the distal end density of the variable diameter thrombus taking support is set to be larger than the proximal end density of the variable diameter thrombus taking support, and after the thrombus with smaller volume is separated from the middle part of the support body in the thrombus moving process, the thrombus can be collected by the distal end of the variable diameter thrombus taking support, so that the thrombus is prevented from being separated and escaped to block other branch vessels, and the variable diameter thrombus taking support has a simple structure and a good using effect.
Drawings
In order to more clearly illustrate the invention or the technical solutions of the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described, and it is obvious that the drawings in the description below are some embodiments of the invention, and other drawings can be obtained according to these drawings without inventive effort for a person skilled in the art.
Wherein:
FIG. 1 is a schematic view of a multifunctional thrombus treatment device according to an embodiment of the present invention;
FIG. 2 is an enlarged view of portion A of FIG. 1;
FIG. 3 is an enlarged view of part B of FIG. 1;
FIG. 4 is an enlarged view of part C of FIG. 1;
FIG. 5 is a schematic view of a variable diameter thrombolysis stent according to an embodiment of the present invention in a first state;
FIG. 6 is a schematic view of a variable diameter thrombolysis stent according to an embodiment of the present invention in a second state;
FIG. 7 is a schematic view of a variable diameter thrombolysis stent in a third state according to an embodiment of the present invention;
FIG. 8 is a schematic view of a variable diameter thrombolysis stent in state four according to an embodiment of the present invention;
FIG. 9 is a schematic diagram of the structure of the nozzle and the third chamber according to the embodiment of the invention;
FIG. 10 is a view showing the image of the multifunctional thrombus treatment device in animal carotid artery according to example 1 of the present invention;
reference numerals:
1. a guide wire; 11. a proximal stop; 12. a distal stop; 13. a flexible tip; 14. a third cavity; 15. a spray hole; 2. a recovery conduit; 21. a first cavity; 3. a diameter-variable thrombus taking bracket; 31. a distal mesh portion; 32. an intermediate screen section; 33. a proximal mesh portion; 34. a sliding opening; 4. fixing the catheter; 41. a second cavity; 5. a connecting handle; 51. a guidewire channel; 52. a first channel; 53. a second channel; 54. a proximal handle; 55. a distal handle; 56. a guidewire adjuster; 6. thrombus; 7. and (5) blood vessels.
Detailed Description
For the purpose of making the objects, technical solutions and advantages of the present invention more apparent, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings, and it is apparent that the described embodiments are some embodiments of the present invention, not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
Referring to fig. 1-10, an embodiment of the present invention provides a multifunctional thrombus treatment device, comprising:
a guide wire 1;
the recovery catheter 2 is sleeved on the outer wall of the guide wire 1, and a first accommodating cavity 21 is formed between the inner wall of the recovery catheter 2 and the outer wall of the guide wire 1;
the variable diameter thrombus taking support 3, the variable diameter thrombus taking support 3 is a reticular structure, the guide wire 1 is arranged on the variable diameter thrombus taking support 3 in a penetrating mode, the diameter of the variable diameter thrombus taking support 3 is variable, the variable diameter thrombus taking support 3 is suitable for blood vessels 7 or thrombus 6 with different widths by changing the diameter of the variable diameter thrombus taking support 3, and the first accommodating cavity 21 is used for accommodating the variable diameter thrombus taking support 3 and used for conveying medicines.
Specifically, the variable diameter thrombus removal holder 3 may be moved relative to the recovery catheter 2 in position to achieve the effect of accommodating the variable diameter thrombus removal holder 3 in the recovery catheter 2, the variable diameter thrombus removal holder 3 may be moved in the axial direction of the recovery catheter 2 to accommodate the variable diameter thrombus removal holder 3 in the recovery catheter 2, or the recovery catheter 2 may be moved in the axial direction of the variable diameter thrombus removal holder 3 to accommodate the variable diameter thrombus removal holder 3 in the recovery catheter 2, and the inner diameter of the recovery catheter 2 may be larger than the minimum diameter that the variable diameter thrombus removal holder 3 can be contracted after capturing the thrombus 6, and a person skilled in the art may determine the minimum diameter that the variable diameter thrombus removal holder 3 can be contracted after capturing the thrombus 6 according to knowledge.
All the benefits mentioned in this description can be achieved simultaneously in one operation by this embodiment.
It should be noted that, the outer diameter of the recovery catheter 2 may be designed to be smaller than the inner diameters of the various blood vessels 7 by those skilled in the art to achieve the movement of the recovery catheter 2 in the various blood vessels 7, or the outer diameter of the recovery catheter 2 may be designed to be smaller than the inner diameter of the blood vessel 7 to be acted according to the need, for example, when the multifunctional thrombus treatment device is used for treating cardiac and cerebral blood vessels, the outer diameter of the recovery catheter 2 is designed to be smaller than the inner diameter of cardiac and cerebral blood vessels, for example, when the multifunctional thrombus treatment device is used for treating vena cava thrombus, the outer diameter of the recovery catheter 2 is designed to be smaller than the inner diameter of vena cava.
In the multifunctional thrombus treatment device of this embodiment, the diameter of the variable diameter thrombus removal stent 3 is adjusted according to the blood vessels 7 with different diameters by arranging the variable diameter thrombus removal stent 3, so as to smoothly move in the blood vessels 7 with different sizes, as shown in fig. 5, the variable diameter thrombus removal stent 3 reduces itself to the minimum diameter, after passing through the thrombus 6, the diameter of the variable diameter thrombus removal stent 3 can be increased according to the size of the thrombus 6 until the variable diameter thrombus removal stent is abutted against the thrombus 6, thereby capturing the thrombus 6 with different sizes in the blood vessels 7, and the variable diameter thrombus removal stent 3 forms a fully-opened state structure as shown in fig. 6.
Through setting up the recovery pipe 2 that forms first appearance chamber 21 with between the seal wire 1, on the one hand the accessible is to the mode of first appearance chamber 21 injection, realizes dissolving thrombus 6, breaks up into a plurality of thrombus 6 that can be caught by the smaller thrombus 6 of the volume of variable diameter thrombus taking support 3 with great volume, or softens thrombus 6, and thrombus 6 after softening is more easily by being in the extrusion cutting of the variable diameter thrombus taking support 3 of diameter increase in-process, has further improved the effect that variable diameter thrombus taking support 3 caught thrombus 6.
The diameter-variable thrombus taking support 3 after the thrombus 6 is captured is contained in the first containing cavity 21 in a manner of reducing the diameter of the diameter-variable thrombus taking support 3, a structure shown in fig. 8 is formed, the diameter-variable thrombus taking support is separated from the blood vessel 7 along with the recovery catheter 2, the recovery catheter 2 plays a role in wrapping the thrombus 6 in the diameter-variable thrombus taking support 3, the thrombus 6 is prevented from separating and escaping in the process that the diameter-variable thrombus taking support 3 is separated from the blood vessel 7, and further, other branch blood vessels 7 are blocked.
As shown in fig. 2, according to one embodiment of the present invention, the variable diameter thrombus removal stent 3 includes a distal mesh portion 31, an intermediate mesh portion 32 and a proximal mesh portion 33 connected in this order, the distal mesh portion 31 and the proximal mesh portion 33 being pressed against each other to press the intermediate mesh portion 32 and thereby enlarge the diameter of the intermediate mesh portion 32, and the distal mesh portion 31 and the proximal mesh portion 33 being separated from each other to stretch the intermediate mesh portion 32 and thereby reduce the diameter of the intermediate mesh portion 32.
The diameter of the variable diameter thrombus-removing stent 3 may be changed by expanding, hinging, or flexibly connecting the distal end mesh portion 31, the intermediate mesh portion 32, and the proximal end mesh portion 33 to each other, or by designing the materials of the distal end mesh portion 31, the intermediate mesh portion 32, and the proximal end mesh portion 33 to be flexible materials, or by changing the diameter of the variable diameter thrombus-removing stent 3 by the variable diameter thrombus-removing stent 3 composed of the distal end mesh portion 31, the intermediate mesh portion 32, and the proximal end mesh portion 33.
According to one embodiment of the present invention, the end of the distal end mesh portion 31 away from the middle mesh portion 32 is provided with a sliding opening 34 sleeved on the outer wall of the guide wire 1 so as to be in sliding fit with the guide wire 1, and the sliding opening 34 is slid along the axial direction of the guide wire 1 so as to be close to or away from the proximal end mesh portion 33.
It will be appreciated that in this embodiment, by providing the sliding opening 34 in sliding engagement with the guide wire 1, the guide wire 1 can guide the movement of the distal end of the variable diameter thrombolytic stent 3 so as to smoothly move, thereby enabling the variable diameter thrombolytic stent 3 to smoothly expand or contract.
As shown in fig. 3 and 9, according to an embodiment of the present invention, the method further includes:
the fixed pipe 4, fixed pipe 4 cover is located the outer wall of seal wire 1, fixed pipe 4 wears to locate retrieve pipe 2, first appearance chamber 21 set up in retrieve between the inner wall of pipe 2 with the outer wall of fixed pipe 4, the one end that keeps away from of near-end net portion 33 middle net portion 32 with the one end fixed connection of fixed pipe 4.
Specifically, the guide wire 1 is in sliding fit with the fixed catheter 4, and the guide wire 1 can move relative to the fixed catheter 4 along the axial direction of the fixed catheter 4, the fixed catheter 4 is in sliding fit with the recovery catheter 2, and the fixed catheter 4 can move relative to the recovery catheter 2 along the axial direction of the recovery catheter 2.
More specifically, as shown in fig. 2, the variable diameter thrombus removal device further comprises a proximal end limiting member 11 and a distal end limiting member 12, wherein the proximal end limiting member 11 and the distal end limiting member 12 are sleeved on the guide wire 1 and are distributed in sequence along the direction from the proximal end of the guide wire 1 to the distal end of the guide wire 1, and the proximal end limiting member 11 abuts against the connection part of the fixed catheter 4 and the variable diameter thrombus removal stent 3 so as to limit the maximum diameter of the variable diameter thrombus removal stent 3, and the distal end limiting member 12 abuts against the sliding opening 34 so as to limit the minimum diameter of the variable diameter thrombus removal stent 3.
According to one embodiment of the invention, the variable diameter thrombolytic stent 3 has a density at its distal end that is greater than its proximal end.
By setting the distal end density of the distal end mesh portion 31 to be greater than the density of the proximal end mesh portion 33, in the process of moving the thrombus 6, after the thrombus 6 with smaller volume is separated from the middle mesh portion, the thrombus can be collected by the distal end mesh portion 31, so that the thrombus 6 is prevented from being separated and escaped to block other branch blood vessels 7, and the thrombus removing device has a simple structure and a good use effect.
In this embodiment, during the thrombus removal, after the variable diameter thrombus removal stent 3 and the fixed catheter 4 pass through the thrombus 6 under the guidance of the guide wire 1, the variable diameter thrombus removal stent 3 is released, and by adjusting the distal end limiter 12 and the proximal end limiter 11, the variable diameter thrombus removal stent 3 is repeatedly changed so that the thrombus 6 is sufficiently captured into the stent, and the guide wire 1, the variable diameter thrombus removal stent 3 and the fixed catheter 4 are dragged back into the recovery catheter 2, so that the escaped thrombus 6 is partially covered by the distal end mesh 31 with a larger density when flowing along with blood flowing toward the distal end of the variable diameter thrombus removal stent 3, thereby preventing the escaped thrombus from occurring.
Specifically, in this embodiment, by repeatedly pushing and pulling the guide wire 1, the diameter of the variable diameter thrombus removal stent 3 can be adjusted arbitrarily and repeatedly, and the sizes of the proximal mesh portion 33, the distal mesh portion 31 and the intermediate mesh portion 32 are changed, so that the capturing chance of thrombus 6 is increased, and the effect of the thrombus removal operation is enhanced.
Specifically, the distal limiter 12 is used in the following manner: pushing the guide wire 1 to enable the guide wire 1 and the fixed catheter 4 to relatively move and enable the guide wire 1 to move towards the distal direction, enabling the distal limiting piece 12 to abut against and push the sliding opening 34 to be away from the fixed catheter 4, enabling the distance between one end of the variable diameter bolt taking support 3, which is used for connecting the fixed catheter 4, and one end of the variable diameter bolt taking support 3, which is used for connecting the sliding opening 34, to be increased, enabling the diameter of the variable diameter bolt taking support 3 to be reduced while stretching, enabling the variable diameter bolt taking support 3 to form a state structure as shown in fig. 5, otherwise enabling the guide wire 1 and the fixed catheter 4 to relatively move and enabling the guide wire 1 to move towards the proximal direction, enabling the variable diameter bolt taking support 3 to restore to the original state under the self elastic action after the support of the distal limiting piece 12 is lost, namely enabling the diameter of the variable diameter bolt taking support 3 to be increased to be reduced to the diameter of the variable diameter bolt taking support 3 when the variable diameter bolt taking support 3 is in a natural state, and enabling the variable diameter bolt taking support 3 to form a state as shown in fig. 6.
It will be appreciated that the outer diameter of the distal stop 12 is greater than the inner diameter of the sliding opening 34 so that the distal stop 12 can abut and push against the sliding opening 34.
Understandably, the maximum diameter of the variable diameter thrombus removal stent 3 is determined by the position of the proximal end limiter 11 on the guide wire 1, and the use mode of the proximal end limiter 11 is as follows: when the elastic performance of the variable diameter thrombus-taking stent 3 is not deactivated, the diameter of the variable diameter thrombus-taking stent 3 is maintained at a certain constant value when the variable diameter thrombus-taking stent 3 is not contacted by the distal end limiting member 12 and the proximal end limiting member 11 in a natural state, or when the elastic performance of the variable diameter thrombus-taking stent 3 is deactivated, or when an obstacle such as thrombus 6 exists at the distal end of the variable diameter thrombus-taking stent 3, the obstacle generates a relative force to the distal end of the variable diameter thrombus-taking stent 3 to the proximal end, the diameter of the variable diameter thrombus-taking stent 3 may be continuously increased under the pushing of the force until the diameter of the variable diameter thrombus-taking stent 3 in the natural state is exceeded, if the diameter of the variable diameter thrombus-taking stent 3 is not limited, the vessel 7 is extruded by the excessive diameter of the variable diameter thrombus-taking stent 3 to cause serious consequences, therefore, when the proximal stopper 11 is provided to move the guide wire 1 and the fixed catheter 4 relatively and move the proximal stopper 11 to a certain position in the axial direction of the variable diameter thrombus removal stent 3, the proximal stopper 11 abuts against the distal end of the fixed catheter 4, the distance between the proximal stopper 11 and the distal stopper 12 is constant due to the fixation of the proximal stopper 11 and the distal stopper 12 to the guide wire 1, at this time, the proximal stopper 11 cannot move further proximally and the distal stopper 12 cannot move further proximally, the variable diameter thrombus removal stent 3 forms a state structure as shown in fig. 7, the slide opening 34 having a tendency to move further proximally cannot move further due to the abutting action of the distal stopper 12, i.e. the guide wire 1 cannot be moved further proximally, further avoiding a further increase in the diameter of the variable diameter thrombolysis stent 3.
It should be noted that, only the distal end limiter 12 may be provided to reduce the diameter of the variable diameter thrombus-removing stent 3, and the diameter of the variable diameter thrombus-removing stent 3 may be increased by the self-elasticity of the variable diameter thrombus-removing stent 3 until the proximal end limiter 11 is restored, so that the beneficial effect of the proximal end limiter 11 may be lost correspondingly, and at the same time, other limiters penetrating through the guide wire 1 may be added at any position inside the variable diameter thrombus-removing stent 3.
Specifically, the diameter-variable thrombus-taking support 3 is formed by braiding shape memory materials such as nickel-titanium alloy wires, so as to achieve the effect of restoring the original shape through the action of self elasticity, and the diameter-variable thrombus-taking support 3 can be additionally provided with a plurality of X-ray developed braided wires, namely the diameter-variable thrombus-taking support 3 is formed by braiding a plurality of nickel-titanium alloy wires and a plurality of X-ray developed braided wires, and the diameter-variable thrombus-taking support 3 can be one or more nickel-titanium alloy wires or one or more X-ray developed braided wires.
More specifically, the proximal stop 11 and the distal stop 12 are provided with a developing material through which the braided wire and the developing stent are passed through the adjusting ring, and the entire process of thrombus removal is visible.
It should be appreciated that, in this embodiment, the outer diameter of the guiding wire 1 is smaller than the inner diameter of the fixing catheter 4, the outer diameter of the fixing catheter 4 is smaller than the inner diameter of the recovering catheter 2, the guiding wire 1 is inserted into the fixing catheter 4, the fixing catheter 4 is inserted into the recovering catheter 2, the variable diameter thrombus taking stand 3 is integrally accommodated in the recovering catheter 2 in the initial state, and the guiding wire 1 is at least partially inserted out of the recovering catheter 2 from the distal end of the fixing catheter 4.
The embodiment has at least two use modes, in the first use mode, the recovery catheter 2 is in a fixed state, the guide wire 1 and the fixed catheter 4 move together, and the variable diameter thrombus taking support 3 can be driven to extend out of the distal end of the recovery catheter 2 or retract into the recovery catheter 2;
in the second mode of use, the recovery catheter 2 and the fixed catheter 4 are fixed, at this time, the proximal end of the variable diameter thrombus-removing stent 3 (i.e., the connection position between the variable diameter thrombus-removing stent 3 and the fixed catheter 4) is in a fixed state, the guide wire 1 slides relative to the fixed catheter 4 and drives the movement of the variable diameter thrombus-removing stent 3, thereby driving the variable diameter thrombus-removing stent 3 to expand or contract, so that the variable diameter thrombus-removing stent 3 can correspond to the internal structure of the blood vessel 7 and/or the structure of the thrombus 6, and realize actions such as cutting, scraping and contraction.
In addition, in this embodiment, the guide wire 1, the fixed catheter 4 and the recovery catheter 2 are sequentially sleeved, so that the guide wire 1 and the variable diameter thrombus-taking support 3 are both accommodated in the recovery catheter 2, the overall structure of the catheter support assembly consisting of the guide wire 1, the variable diameter thrombus-taking support 3, the fixed catheter 4 and the recovery catheter 2 is more compact, and in the operation process, other guide wires are not required to be additionally arranged, so that the volume of equipment stored in the patient body in the thrombus-taking operation process can be reduced, the damage to the patient body can be reduced, the transportation and the use of the catheter support assembly can be facilitated, the time of clinical intervention operation is greatly simplified, and the use effect is good.
According to one embodiment of the present invention, the inner wall of the fixing catheter 4 and the outer wall of the guiding wire 1 are provided with a second cavity 41, the second cavity 41 penetrates through two ends of the fixing catheter 4, and one end of the second cavity 41 away from the proximal net part 33 is used for injecting medicine, so that the injected medicine is output from one end of the second cavity 41 close to the proximal net part 33, so as to further improve thrombolysis effect.
Specifically, the outer wall of the fixed catheter 4 may be further provided with a plurality of application holes, and the application holes are disposed at a position near the distal end of the fixed catheter 4; therefore, when the thrombolytic liquid medicine is conveyed through the fixed catheter 4, the liquid medicine can be dispersed through the medicine application holes, so that the medicine application range of the liquid medicine is improved, and the use effect is good.
As shown in fig. 4, according to an embodiment of the present invention, further comprising:
the connecting handle 5, the connecting handle 5 is provided with a guide wire channel 51, a first channel 52 and a second channel 53, the guide wire channel 51 is used for conveying the guide wire 1, the first channel 52 is used for conveying the fixed catheter 4, and the second channel 53 is used for conveying the recovery catheter 2.
It will be appreciated that in this embodiment, by providing the above-mentioned connection handle 5, the guide wire 1, the fixing catheter 4 and the recovery catheter 2 can be respectively transported and controlled through the guide wire channel 51, the first channel 52 and the second channel 53, so as to realize the thrombolysis operation, which has a compact structure and is convenient to operate, and simultaneously, the thrombolysis or other therapeutic drugs are respectively injected into the third cavity 14, the second cavity 41 and the first cavity 21 through the guide wire channel 51, the first channel 52 and the second channel 53.
Specifically, the first channel 52 and the second channel 53 are both three-way pipes, one pipe orifice of the first channel 52 is suitable for being communicated with the guide wire channel 51 and being suitable for the guide wire 1 to penetrate, the other pipe orifice is suitable for the fixing catheter 4 to penetrate, the third pipe orifice is suitable for being communicated with one pipe orifice of the second channel 53 and being suitable for the fixing catheter 4 to penetrate, the third pipe orifice is also suitable for injecting thrombolytic drugs or other therapeutic drugs, the other pipe orifice of the second channel 53 is suitable for the recovery catheter 2 to penetrate, or for injecting thrombolytic drugs or other therapeutic drugs, and the third pipe orifice is suitable for the recovery catheter 2 to penetrate.
According to one embodiment of the present invention, the connection handle 5 includes a proximal handle 54 and a distal handle 55 which are detachably connected, the guide wire channel 51 and the first channel 52 are provided on the proximal handle 54, and the second channel 53 is provided on the distal handle 55.
Through setting up near-end handle 54 and distal end handle 55 that can dismantle the connection, in the use, can select near-end handle 54 and distal end handle 55 of corresponding structure and make up according to actual operation demand, can also be provided with third passageway, fourth passageway etc. on the distal end handle 55 to realize corresponding function, do not do the unique restriction here.
Specifically, the connection handle 5 is further provided with a guide wire adjusting member 56, the guide wire 1 is threaded through the guide wire adjusting member 56, the guide wire adjusting member 56 is used for driving the guide wire 1 to move relative to the connection handle 5, and more specifically, external threads matched with the guide wire adjusting member 56 in a threaded manner can be arranged on the periphery of the guide wire 1, so that the purpose that the guide wire 1 can move relative to the connection handle 5 can be achieved by rotating the guide wire adjusting member 56.
More specifically, in the present embodiment, the extending direction of the first passage 52 and the extending direction of the guide wire passage 51 form an angle therebetween, and the first passage 52 is inclined toward the proximal end of the connection handle 5; the second channel 53 also has an angle between the direction of extension of the guidewire channel 51 and the second channel 53 is inclined in a direction towards the proximal end of the connection handle 5; from this setting, the connection handle 5 wholly forms Y type structure, not only can improve the conveying resistance of fixed pipe 4 and recovery pipe 2, avoids blockking up buckling, and in the use, medical personnel only need to handle connection handle 5 and can operate guide wire 1, fixed pipe 4 and recovery pipe 2 respectively, and it is convenient to use.
According to one embodiment of the invention, the distal end of the guide wire 1 protrudes from the distal end of the variable diameter thrombolysis stent 3 and is provided with a flexible tip 13.
It is thus provided that when the guide wire 1 is extended into the blood vessel 7, the flexible tip 13 can be deformed when touching the inner wall of the blood vessel 7 or an obstacle in the blood vessel 7, so as to avoid puncture damage to the inner wall of the blood vessel 7.
Specifically, a third cavity 14 penetrating through two ends of the guide wire 1 is provided in the guide wire 1, the guide wire 1 is provided with a spray hole 15 for communicating the third cavity 14 with the outside of the guide wire 1, and the medicine is injected into the third cavity 14 from the proximal end of the guide wire 1 so as to be output to the outside of the guide wire 1 through the spray hole 15.
More specifically, one end of the injection hole 15 for delivering the drug to the outside of the guide wire 1 is directed toward the variable diameter thrombolytic stent 3.
The method for using the multifunctional thrombus treatment device provided by the second aspect of the invention comprises the following steps:
controlling the diameter of the variable diameter thrombus taking support 3 to be smaller than the diameter of the blood vessel 7, penetrating the guide wire 1 into the blood vessel 7 and penetrating the guide wire 1 through thrombus 6;
injecting a drug into the first lumen 21 from an end of the first lumen 21 near the proximal end of the guide wire 1, such that the drug is delivered from the distal end of the first lumen 21 near the guide wire 1 and acts on the thrombus 6 to soften or break up the thrombus 6;
increasing the diameter of the variable diameter thrombus taking support 3, enabling the variable diameter thrombus taking support 3 to pass through thrombus 6 originally positioned on the outer side of the variable diameter thrombus taking support 3 in the diameter increasing process, enabling the thrombus 6 to be contained between the inner side of the variable diameter thrombus taking support 3 and the outer side of the guide wire 1 after the diameter is increased, and capturing the thrombus 6;
specifically, the diameter of the variable diameter thrombus taking support 3 is increased, so that the variable diameter thrombus taking support 3 passes through thrombus 6 originally positioned on the outer side of the variable diameter thrombus taking support 3 in the diameter increasing process, and the thrombus 6 is accommodated between the inner side of the variable diameter thrombus taking support 3 and the outer side of the guide wire 1 after the diameter is increased, so that the thrombus 6 is captured;
while, before or after repeatedly changing the diameter of the stent to catch thrombus, the drug is injected from the proximal end of the first, second and/or third chambers 21, 41 and/or 14, and flows out near or inside the thrombus tissue 6 at the distal end of the first, second and/or third chambers 21, 41 and/or 14 so as to soften or decompose the thrombus 6, thereby increasing the effect of catching thrombus by the stent.
Example 1: the multifunctional thrombus treatment device of the present invention was produced as shown in fig. 1. The produced variable diameter thrombus-removing stent 3 is implanted into the carotid artery of a pig. Under an X-ray machine, the variable diameter thrombus taking support 3 prepared by a developing wire of the multifunctional thrombus treatment device and the proximal limiting piece 11 and the distal limiting piece 12 on the guide wire 1 are clearly visible, the guide wire 1 is pushed and pulled, and the variable diameter thrombus taking support 3 can freely change in carotid arteries. The guide wire 1 is unfolded, and the variable diameter thrombus taking support 3 can be easily taken into the recovery catheter 2. Fig. 10 is an image of the variable diameter thrombus formation stent 3 in the carotid artery of a pig.
In the description of the present specification, a description referring to terms "one embodiment," "some embodiments," "examples," "specific examples," or "some examples," etc., means that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the embodiments of the present invention. In this specification, schematic representations of the above terms are not necessarily directed to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, the different embodiments or examples described in this specification and the features of the different embodiments or examples may be combined and combined by those skilled in the art without contradiction.
Finally, it should be noted that: the above embodiments are only for illustrating the technical solution of the present invention, and are not limiting; although the invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical scheme described in the foregoing embodiments can be modified or some technical features thereof can be replaced by equivalents; such modifications and substitutions do not depart from the spirit and scope of the technical solutions of the embodiments of the present invention.
Claims (6)
1. A multi-functional thrombus treatment device, comprising:
a guide wire (1);
the recovery catheter (2) is sleeved on the outer wall of the guide wire (1), and a first containing cavity (21) is formed between the inner wall of the recovery catheter (2) and the outer wall of the guide wire (1);
the variable-diameter thrombus taking support (3), the variable-diameter thrombus taking support (3) is of a net structure, and the guide wire (1) is arranged in the variable-diameter thrombus taking support (3) in a penetrating mode;
the diameter-variable thrombus taking support (3) is suitable for blood vessels (7) or thrombus (6) with different widths by changing the diameter of the diameter-variable thrombus taking support (3), and the first accommodating cavity (21) is used for accommodating the diameter-variable thrombus taking support (3) and delivering medicines; the diameter-variable thrombus taking support (3) comprises a distal net part (31), an intermediate net part (32) and a proximal net part (33) which are sequentially connected, wherein the distal net part (31) and the proximal net part (33) are mutually closed to press the intermediate net part (32) so as to enlarge the diameter of the intermediate net part (32), and the distal net part (31) and the proximal net part (33) are mutually separated to stretch the intermediate net part (32) so as to reduce the diameter of the intermediate net part (32); one end of the distal end net part (31) far away from the middle net part (32) is sleeved on a sliding opening (34) of the outer wall of the guide wire (1) so as to be in sliding fit with the guide wire (1), and the sliding opening (34) is slid along the axial direction of the guide wire (1) so as to be close to or far away from the proximal end net part (33);
the fixed catheter (4), the fixed catheter (4) is sleeved on the outer wall of the guide wire (1), the fixed catheter (4) is arranged on the recovery catheter (2) in a penetrating mode, the first accommodating cavity (21) is arranged between the inner wall of the recovery catheter (2) and the outer wall of the fixed catheter (4), and one end, far away from the middle net part (32), of the near-end net part (33) is fixedly connected with one end of the fixed catheter (4);
still include proximal end locating part (11) and distal end locating part (12), proximal end locating part (11) with distal end locating part (12) cover is located seal wire (1), and follow from the proximal end of seal wire (1) to the direction of the distal end of seal wire (1) distributes in proper order, through proximal end locating part (11) butt fixed catheter (4) with the junction of variable diameter thrombus taking support (3), in order to right the maximum diameter of variable diameter thrombus taking support (3) is restricted, and through distal end locating part (12) butt sliding opening (34) mode, in order to right the minimum diameter of variable diameter thrombus taking support (3) is restricted.
2. The multifunctional thrombus treatment device according to claim 1, characterized in that the inner wall of the fixation catheter (4) and the outer wall of the guiding wire (1) are provided with a second cavity (41), the second cavity (41) penetrates through the two ends of the fixation catheter (4), one end of the second cavity (41) away from the proximal net part (33) is used for injecting medicine, and one end of the second cavity (41) close to the proximal net part (33) is used for outputting medicine.
3. The multifunctional thrombi treatment device of claim 2, further comprising:
connect handle (5), seal wire passageway (51), first passageway (52) and second passageway (53) have been seted up to connect handle (5), seal wire passageway (51) are used for carrying guide wire (1), first passageway (52) are used for carrying fixed pipe (4), second passageway (53) are used for carrying recovery pipe (2).
4. A multifunctional thrombus treatment device according to claim 3, characterized in that said connection handle (5) comprises a proximal handle (54) and a distal handle (55) removably connected, said guide wire channel (51) and said first channel (52) being provided on said proximal handle (54) and said second channel (53) being provided on said distal handle (55).
5. The device according to claim 1, characterized in that the distal end of the guide wire (1) protrudes from the distal end of the variable diameter thrombolysis stent (3) and is provided with a flexible tip (13).
6. The device according to claim 1, characterized in that the variable diameter thromboembolic stent (3) has a density at its distal end that is greater than its proximal end.
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| CN114711896B (en) * | 2022-06-08 | 2022-10-21 | 深圳佰特微医疗科技有限公司 | Thrombus taking device |
| CN115607233A (en) * | 2022-10-28 | 2023-01-17 | 广东博迈医疗科技股份有限公司 | Thrombus taking device |
| CN115813486B (en) * | 2022-10-31 | 2023-10-24 | 广东博迈医疗科技股份有限公司 | Bolt breaking device, bolt taking support and bolt taking system |
| CN117137578B (en) * | 2022-11-01 | 2024-04-23 | 上海珩畅医疗科技有限公司 | Thrombolysis device, thrombus treatment device and using method thereof |
| CN116269651B (en) * | 2022-12-06 | 2023-10-10 | 杭州亿科医疗科技有限公司 | Prevent that thrombus extraction net from releasing in advance's thrombus extraction device |
| CN116370030B (en) * | 2022-12-06 | 2023-08-11 | 杭州亿科医疗科技有限公司 | Thrombus taking device capable of preventing thrombus from escaping in withdrawal process |
| CN117814871A (en) * | 2023-02-23 | 2024-04-05 | 萃杰医疗科技(南京)有限公司 | Directional thrombolysis catheter device |
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