CN114366373A - Skull horizontal position leveling instrument and leveling method for brain three-dimensional positioning injection - Google Patents
Skull horizontal position leveling instrument and leveling method for brain three-dimensional positioning injection Download PDFInfo
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- CN114366373A CN114366373A CN202210104490.4A CN202210104490A CN114366373A CN 114366373 A CN114366373 A CN 114366373A CN 202210104490 A CN202210104490 A CN 202210104490A CN 114366373 A CN114366373 A CN 114366373A
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- 210000004556 brain Anatomy 0.000 title claims abstract description 63
- 210000003625 skull Anatomy 0.000 title claims abstract description 51
- 238000002347 injection Methods 0.000 title claims abstract description 21
- 239000007924 injection Substances 0.000 title claims abstract description 21
- 238000000034 method Methods 0.000 title claims description 13
- 230000005540 biological transmission Effects 0.000 claims description 9
- 230000001360 synchronised effect Effects 0.000 claims description 5
- 238000011160 research Methods 0.000 abstract description 5
- 239000002699 waste material Substances 0.000 abstract 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 13
- 241000700159 Rattus Species 0.000 description 13
- 239000000243 solution Substances 0.000 description 7
- 238000013461 design Methods 0.000 description 5
- 238000005259 measurement Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 2
- 241000699670 Mus sp. Species 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
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- A61D—VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS
- A61D7/00—Devices or methods for introducing solid, liquid, or gaseous remedies or other materials into or onto the bodies of animals
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Abstract
The invention relates to the technical field of brain science research instruments, and provides a skull horizontal position leveling instrument for brain stereotaxic injection, which comprises a first main body, a Bregma site positioning piece, a Lambda site positioning needle and a level instrument, wherein the Bregma site positioning piece is arranged on the first main body, the Lambda site positioning needle is arranged on the first main body in an adjustable position, the first positioning needle and the second positioning needle are arranged on the first main body in an adjustable position and are respectively arranged at two sides of a connecting line of the Bregma site positioning piece and the Lambda site positioning needle, and the level instrument is arranged on the first main body. The Bregma site positioning piece is a gradiometer with a cross reticle, and the cross reticle is used for aligning the Bregma site of the brain. The first main body is a transparent plate body and is triangular, and the Lambda point positioning pin, the first positioning pin and the second positioning pin are respectively positioned at three angular positions of the first main body. Through the technical scheme, the technical problems of complex operation, time waste and labor waste when the brain locates the target point in the prior art are solved.
Description
Technical Field
The invention relates to the technical field of brain science research instruments, in particular to a horizontal position leveling instrument and a leveling method for a skull through brain stereotaxic injection.
Background
In the research process in the field of brain science, an indispensable instrument is a brain stereotaxic apparatus, and accurate positioning injection can be realized by means of a brain atlas. As shown in FIG. 1, which is a schematic diagram of Bregma and Lambda sites in the mouse brain, the coordinate (0, 0, 0,) point is first needed according to Bregma in positioning. The skull is required to be adjusted to be in a horizontal plane, and then the target site is positioned according to the corresponding site coordinates on the brain atlas. Wherein, the adjustment of the horizontal plane of the skull requires that the Bregma and Lambda sites are on the same horizontal plane and that the left and right brains are symmetrically on the same horizontal plane. In the actual positioning process, a plurality of steps which are seemingly simple also need a long time to complete positioning, at present, a good method for quickly flattening the skull surface is not provided, repeated adjustment is mainly carried out by using a positioning instrument, the operation is complex, time-consuming and labor-consuming, and the problem becomes a pain point and a difficulty point for laboratory staff to position a target point during brain science research.
Disclosure of Invention
The invention provides a skull horizontal position leveling instrument for brain stereotaxic injection, which solves the technical problems of complex operation, time consumption and labor consumption when a target point is positioned in the brain in the related technology.
The technical scheme of the invention is as follows:
a skull horizontal position leveling instrument for brain stereotaxic injection comprises
A first main body which is provided with a first main body,
a Bregma site locator disposed on the first body,
a Lambda site positioning needle which is arranged on the first main body in an adjustable position,
the first positioning needle and the second positioning needle are both arranged on the first main body in an adjustable position and are respectively positioned at two sides of a connecting line of the Bregma site positioning piece and the Lambda site positioning needle,
a level disposed on the first body.
As a further technical scheme, the Bregma site positioning piece is a gradiometer with a cross-shaped reticle, and the cross-shaped reticle is used for aligning the Bregma site of the brain.
As a further technical solution, the first main body is a transparent plate and is triangular, and the Lambda site positioning pin, the first positioning pin and the second positioning pin are respectively located at three angular positions of the first main body.
As a further technical solution, the cross-shaped score line is located on the first main body and between the first positioning needle and the second positioning needle.
As a further technical solution, the Lambda site positioning pin, the first positioning pin and the second positioning pin are perpendicular to the first body.
As a further technical solution, the Lambda site positioning pin, the first positioning pin and the second positioning pin are all slidably disposed on the first body.
As a further technical solution, the first main body has a first sliding slot, a second sliding slot, and a third sliding slot, the first positioning pin, the second positioning pin, and the Lambda point positioning pin are slidably disposed in the first sliding slot, the second sliding slot, and the third sliding slot, respectively, the first sliding slot and the second sliding slot are collinear, an intersection point of an extension line of the first sliding slot and an extension line of the third sliding slot is a center point of the cross-shaped scribe line,
the first sliding groove (101), the second sliding groove (102) and the third sliding groove (103) are provided with scale marks.
As a further technical scheme, the bubble level gauge further comprises locking nuts, wherein the Lambda point positioning pin, the first positioning pin and the second positioning pin are respectively provided with the locking nuts and used for being locked on the first main body, and the bubble level gauge is a universal bubble level gauge.
As a further technical solution, the device further comprises a synchronization component for the equal distance and synchronous movement of the first positioning needle and the second positioning needle from the cross-shaped reticle, comprising
A first connecting part arranged on the first positioning needle and vertical to the first positioning needle,
a second connecting part arranged on the second positioning needle and vertical to the second positioning needle,
the first rack is arranged on the first connecting part and is vertical to the first connecting part and the first positioning needle,
the second rack is arranged on the second connecting part and is vertical to the second connecting part and the second positioning needle, the first rack is parallel to the second rack,
the transmission gear is rotationally arranged on the first main body, the first rack is meshed with the second rack,
and the rotating handle is arranged on the transmission gear.
A skull horizontal position leveling method by brain stereotaxic injection, which comprises the following steps,
s1, fixing the head of the mouse on the stereotaxic apparatus, exposing the surface of the skull,
s2, aligning the center point of the Bregma site locating piece with the Bregma site of the skull, aligning the Lambda site locating needle with the Lambda site of the skull,
s3, adjusting the first positioning needle and the second positioning needle to be symmetrical and equidistant to the center point of the Bregma locus positioning piece and keeping the position abutting with the skull to be fixed,
and S4, adjusting the stereotaxic apparatus to enable the level meter to be horizontal, thereby completing skull level leveling.
The working principle and the beneficial effects of the invention are as follows:
according to the skull horizontal position leveling instrument, the skull horizontal position leveling instrument for brain stereotaxic injection is matched with the brain stereotaxic instrument, so that rapid and accurate leveling can be realized, convenient operation is well realized, and the skull horizontal position adjusting method is efficient, rapid and accurate. The first body of the graduator is a body part used for bearing parts, the Bregma site locating piece is a fixed position on the first body and is used for aligning a Bregma site of a mouse brain, the Lambda site locating pin is a position-adjustable Lambda site which is used for adjusting to contact and point to the mouse brain, the first locating pin and the second locating pin are both position-adjustable and are used for adjusting to contact with the mouse brain and keeping the two symmetrical about the Bregma site locating piece, in the prior art, an experimenter uses a brain stereotaxic apparatus to mostly level through two points of the Bregma site and the Lambda site, the uneven problem always occurs, the inventor improves that the first locating pin and the second locating pin are added on the basis that the Bregma site is aligned with the Bregma site locating piece, when the first locating pin and the second locating pin are adjusted to be symmetrical about the Bregma site, the lower end points of the first locating pin and the second locating pin just form an isosceles triangle with the Bregma site locating piece, and the upper end points of the two and the Bregma site of the rat brain also form an isosceles triangle, so that the final leveling of the rat brain is transferred to the leveling of the first main body, the leveling of the rat brain is realized as long as the first main body is adjusted to be horizontal, the leveling is simple as the level gauge is arranged on the first main body, the leveling step is greatly simplified, and the efficient, quick and accurate leveling of the skull of the rat brain is finally realized.
Drawings
The present invention will be described in further detail with reference to the accompanying drawings and specific embodiments.
FIG. 1 is a schematic representation of the positions of Bregma and Lambda sites in the brain of a mouse;
FIG. 2 is a schematic structural view of the present invention;
FIG. 3 is a schematic structural diagram of another embodiment of the present invention;
in the figure: a first main body (1), a first sliding groove (101), a second sliding groove (102), a third sliding groove (103), a Bregma site positioning piece (2), a cross-shaped reticle (201), a Lambda site positioning needle (3), a locking nut (301), a first positioning needle (4), a second positioning needle (5), a level meter (6), a synchronizing component (7), a first connecting part (709), a second connecting part (710), a first rack (711), a second rack (712), a transmission gear (713) and a rotating handle (714),
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any inventive step, are intended to be within the scope of the present invention.
As shown in FIGS. 2 to 3, the present embodiment provides a skull horizontal positioning instrument for brain stereotaxic injection, which comprises
The first body 1 is provided with a first opening,
a Bregma site locator 2, disposed on the first body 1,
a Lambda site positioning pin 3, the position of which can be adjusted and arranged on the first main body 1,
the first positioning pin 4 and the second positioning pin 5 are both arranged on the first main body 1 in an adjustable position and are respectively positioned at two sides of the connecting line of the Bregma site positioning piece 2 and the Lambda site positioning pin 3,
and a level 6 provided on the first body 1.
In the embodiment, in consideration of the prior art, when performing a rat brain research, the rat brain always needs to be placed in the brain stereotaxic apparatus, the skull level needs to be searched and adjusted in the operation process of the brain stereotaxic apparatus, the skull stereotaxic apparatus needs to be operated to be adjusted repeatedly, the adjustment is not good, a lot of unnecessary energy is wasted, the prior art has no way to realize quick and accurate positioning, in order to solve the technical problem, the inventor manufactures a brain stereotaxic injection skull level leveler used in cooperation with the brain stereotaxic apparatus through long-term improved design, and the brain stereotaxic apparatus can be matched with the brain stereotaxic apparatus to realize quick and accurate leveling, thereby well realizing convenient operation and a high-efficiency, quick and accurate skull level adjusting method.
The first body 1 of the leveler is designed to be a main body part for bearing parts, the Bregma site locator 2 is a fixed position on the first body 1 for aligning the Bregma site of the mouse brain, the Lambda site locator 3 is a position-adjustable position on the first body 1 for adjusting to the Lambda site contacting and pointing to the mouse brain, the first locator 4 and the second locator 5 are both position-adjustable for adjusting to contact with the mouse brain and keeping the two symmetrical with respect to the Bregma site locator 2, in the prior art, the laboratory staff mostly carry out leveling through two points of the Bregma site and the Lambda site by utilizing the stereotaxic apparatus, the problem of leveling always occurs, the inventor improves that when the first locator 4 and the second locator 5 are added on the basis of aligning the Bregma site locator 2 by utilizing the Bregma site, when the two are adjusted to be symmetrical with respect to the Bregma site, because the first locator 4 and the second locator 5 are the same length, the lower end points of the two and the Bregma site positioning piece 2 just form an isosceles triangle, and the upper end points of the two and the Bregma site of the rat brain also form an isosceles triangle, so that the final leveling of the rat brain is transferred to the leveling of the first main body 1, the leveling of the rat brain is realized as long as the first main body 1 is adjusted to be horizontal, the leveling instrument 6 is arranged on the first main body 1, the leveling is simple, the leveling step is greatly simplified, and the efficient, rapid and accurate leveling of the skull of the rat brain is finally realized.
In this embodiment, the Lambda site positioning pin 3 is adjustably disposed on the first body 1, and the first positioning pin 4 and the second positioning pin 5 are adjustably disposed on the first body 1, so that the Lambda site positioning pin can be applied to rats and mice of different sizes, thereby achieving wider applicability.
When the leveling instrument is used, the head of a mouse is fixed on the stereo positioning instrument, and the surface of a skull is exposed; then aligning the center point of the Bregma site positioning piece 2 to the Bregma site of the skull, and aligning the Lambda site positioning needle 3 to the Lambda site of the skull; then the first positioning needle 4 and the second positioning needle 5 are adjusted to be symmetrical and equidistant from the center point of the Bregma site positioning piece 2 and the position abutting against the skull is kept fixed; and finally, adjusting the stereotaxic instrument to enable the level instrument 6 to be horizontal, thereby finishing the leveling of the skull horizontal position. Repeated adjustment of the quantity is not needed, and the operation is not complex, time and labor are not needed.
Further, the Bregma site locator 2 is a gradiometer with a cross-shaped score 201, the cross-shaped score 201 being used to align the Bregma site of the brain. Therefore, the alignment can be more quickly and accurately carried out, and the use convenience is ensured.
Further, first main part 1 is the transparent plate body, has increased the operation visibility, and the design of plate body makes the leveling more convenient, and is triangle-shaped, more corresponds with the rat brain, can not too much more, also can not too little not enough, and the structure is more reasonable, and Lambda position point pilot pin 3, first pilot pin 4 and second pilot pin 5 are located the three angular position department of first main part 1 respectively, and the structure is compacter, and can also design for three needles etc. length, realize accurate level.
Further, a cross-shaped score line 201 is located on the first body 1 and between the first positioning pin 4 and the second positioning pin 5. The mouse brain fixing plane is ensured to be parallel to the plate body structure of the first main body 1.
Further, the Lambda site positioning pin 3, the first positioning pin 4, and the second positioning pin 5 are perpendicular to the first body 1. The vertical structure can further ensure the measurement precision and the reasonableness.
Further, the Lambda site positioning pin 3, the first positioning pin 4, and the second positioning pin 5 are slidably disposed on the first body 1. The sliding position can be adjusted more conveniently, and the aim of conveniently adjusting and locking can be achieved.
Further, first main part 1 is last to have first spout 101, second spout 102, third spout 103, first pilot pin 4, second pilot pin 5, Lambda position pilot pin 3 slides respectively and sets up in first spout 101, second spout 102, third spout 103, first spout 101 and second spout 102 collineation, the point of intersection of first spout 101 extension line and third spout 103 extension line is the central point of cross groove 201, a vertical structure has been constituteed to three spout for three pilot pin also encloses an isosceles triangle in the city, correspond with the symmetrical structure of mouse brain, guaranteed the realization of level.
The first sliding groove (101), the second sliding groove (102) and the third sliding groove (103) are provided with scale marks. The design of the scale marks enables the adjustment of the first positioning pin 4, the second positioning pin 5 and the Lambda point positioning pin 3 to be more accurate, and the first positioning pin 4 and the second positioning pin 5 can also quickly realize the equality of the distance Bregma point positioning piece 2, thereby ensuring the realization of measurement without an additional measuring tool for carrying out complex measurement.
Further, the measuring device comprises a locking nut 301, the Lambda point positioning needle 3, the first positioning needle 4 and the second positioning needle 5 are respectively provided with the locking nut 301, the positioning needles can be locked on the first main body 1 by screwing, the accuracy of the measuring process is guaranteed, the level gauge 6 is a universal level bubble level gauge, the leveling of the first main body 1 can be realized more accurately, and the leveling of the skull of the rat brain is achieved.
Further, a synchronization assembly 7 is included for the equal distance and synchronized movement of the first positioning needle 4 and the second positioning needle 5 from the cross reticle 201, including
A first connecting portion 709 disposed on the first positioning pin 4 and perpendicular thereto,
a second connection part 710 disposed on the second positioning pin 5 and perpendicular thereto,
a first rack 711 disposed on the first connecting portion 709 and perpendicular to both the first connecting portion 709 and the first positioning pin 4,
a second rack 712 disposed on the second connecting portion 710 and perpendicular to the second connecting portion 710 and the second positioning pin 5, the first rack 711 being parallel to the second rack 712,
a transmission gear 713 rotatably provided on the first body 1, the first rack 711 being engaged with the second rack 712,
a rotating handle 714 is provided on the transmission gear 713.
In this embodiment, in consideration that the first positioning pin 4 and the second positioning pin 5 need to be adjusted respectively and the distance between the two and the central point of the cross reticle 201 needs to be equal, and the adjustment efficiency is not high enough, the synchronization assembly 7 is especially designed to realize the synchronous movement of the first positioning pin 4 and the second positioning pin 5, and also to ensure that the distance between the two and the central point of the cross reticle 201 is always equal, thereby further improving the adjustment efficiency. The first positioning needle 4 and the second positioning needle 5 move in a correlation mode through the first rack 711 and the second rack 712, the transmission gear 713 drives the first rack 711 and the second rack 712 to move reversely and synchronously, and therefore the first positioning needle 4 and the second positioning needle 5 move reversely and synchronously finally, a good adjusting effect is achieved, the rack and the gear can be matched with enough precision, the good high-precision leveling requirement can be met, and a design spring can be additionally arranged, one end of the spring is connected with the first positioning needle 4, one end of the spring is connected with the second positioning needle 5, the force for enabling the first positioning needle 4 and the second positioning needle 5 to approach each other is provided, and the precision and the adjusting convenience can be further improved. A rotating handle 714 may be further disposed on the transmission gear 713, and by rotating one handle, the synchronous and reverse movement of the first positioning pin 4 and the second positioning pin 5 can be realized, and of course, the following movement of the second positioning pin 5 can also be realized by moving the first positioning pin 4 alone, and after the adjustment to the desired position, the locking nut 301 is operated to lock to the first body 1. The first connecting portion 709 and the second connecting portion 710 are designed to achieve better structural abdication, so that the problem that a rack and pinion is located below the cross reticle 201 and the problem that the rack and pinion is located below the first positioning pin and the second positioning pin 5 and the influence caused by the rack and pinion on the first positioning pin and the second positioning pin and the adjustment problem are solved.
The embodiment also provides a leveling method of the skull horizontal position leveling instrument for brain stereotaxic injection, which comprises the following steps,
s1, fixing the head of the mouse on the stereotaxic apparatus, exposing the surface of the skull,
s2, the center point of the Bregma site positioning piece 2 is aligned with the Bregma site of the skull, the Lambda site positioning needle 3 is aligned with the Lambda site of the skull,
s3, adjusting the first positioning needle 4 and the second positioning needle 5 to be symmetrically equidistant from the center point of the Bregma site positioning piece 2 and keeping the position abutting with the skull fixed,
and S4, adjusting the stereotaxic apparatus to enable the level meter 6 to be horizontal, thereby completing skull horizontal positioning.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions, improvements, etc. within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A skull horizontal position leveling instrument for brain stereotaxic injection is characterized by comprising
A first body (1) having a first end,
a Bregma site locator (2) disposed on the first body (1),
a Lambda site positioning needle (3) which is arranged on the first main body (1) in an adjustable position,
a first positioning needle (4) and a second positioning needle (5) which are both arranged on the first main body (1) in an adjustable position and are respectively positioned at two sides of the connecting line of the Bregma site positioning piece (2) and the Lambda site positioning needle (3),
a level (6) disposed on the first body (1).
2. The apparatus according to claim 1, wherein the Bregma site locator (2) is a gradiometer having a cross-shaped score line (201), the cross-shaped score line (201) being used to align with the Bregma site of the brain.
3. The skull horizontal level-level gauge for brain stereotactic injection according to claim 1, characterized in that said first body (1) is a transparent plate and triangular, and said Lambda site needle (3), said first needle (4) and said second needle (5) are located at three angular positions of said first body (1), respectively.
4. The brain stereotactic injection skull level-leveling instrument according to claim 2, wherein said cross-shaped score line (201) is located on said first body (1) and between said first positioning needle (4) and said second positioning needle (5).
5. The skull horizontal level-finder for brain stereotactic injection according to claim 4, wherein said Lambda site needle (3), said first needle (4) and said second needle (5) are all perpendicular to said first body (1).
6. The skull horizontal level-positioning instrument for brain stereotactic injection according to claim 5, characterized in that said Lambda site positioning needle (3), said first positioning needle (4) and said second positioning needle (5) are all slidingly arranged on said first body (1).
7. The skull horizontal level-positioning instrument for brain stereotactic injection according to claim 6, wherein said first body (1) has a first sliding groove (101), a second sliding groove (102), and a third sliding groove (103), said first positioning needle (4), said second positioning needle (5), and said Lambda-site positioning needle (3) are slidably disposed in said first sliding groove (101), said second sliding groove (102), and said third sliding groove (103), respectively, said first sliding groove (101) and said second sliding groove (102) are collinear, an intersection point of an extension line of said first sliding groove (101) and an extension line of said third sliding groove (103) is a central point of said cross-shaped reticle (201),
the first sliding groove (101), the second sliding groove (102) and the third sliding groove (103) are provided with scale marks.
8. The skull horizontal positioning instrument for brain stereotactic injection according to claim 1, further comprising a locking nut (301), wherein said Lambda site positioning needle (3), said first positioning needle (4) and said second positioning needle (5) are all provided with said locking nut (301) for locking to said first body (1), and said level instrument (6) is a universal level bubble level instrument.
9. The brain stereotactic injection skull level-leveling instrument according to claim 2, further comprising a synchronization assembly (7) for equal distance and synchronized movement of said first positioning needle (4) and said second positioning needle (5) from said cross-hair (201), comprising
A first connecting portion (709) provided on the first positioning pin (4) and perpendicular thereto,
a second connecting portion (710) provided on the second positioning pin (5) and perpendicular thereto,
a first rack (711) disposed on the first connecting portion (709) and perpendicular to both the first connecting portion (709) and the first positioning pin (4),
a second rack (712) disposed on the second connecting portion (710) and perpendicular to both the second connecting portion (710) and the second positioning pin (5), the first rack (711) being parallel to the second rack (712),
a transmission gear (713) rotatably disposed on the first body (1), the first rack (711) and the second rack (712) being engaged with each other,
and a rotating handle (714) arranged on the transmission gear (713).
10. The leveling method by using the skull horizontal position leveling instrument for brain stereotaxic injection according to any one of claims 1 to 9, comprising the following steps,
s1, fixing the head of the mouse on the stereotaxic apparatus, exposing the surface of the skull,
s2, aligning the center point of the Bregma site locating piece (2) with the Bregma site of the skull, aligning the Lambda site locating needle (3) with the Lambda site of the skull,
s3, adjusting the first positioning needle (4) and the second positioning needle (5) to be symmetrical and equidistant from the center point of the Bregma site positioning piece (2) and keeping the position abutting against the skull fixed,
and S4, adjusting the stereotaxic apparatus to enable the level meter (6) to be horizontal, thereby completing skull horizontal positioning.
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| CN202210104490.4A CN114366373A (en) | 2022-01-28 | 2022-01-28 | Skull horizontal position leveling instrument and leveling method for brain three-dimensional positioning injection |
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| DE4204544A1 (en) * | 1992-02-15 | 1993-08-19 | Stephan Hoerschelmann | Determining position of any part of skull with respect to nasion - involves horizontal beam structure with sliding elements mounted on nasion |
| US20070149878A1 (en) * | 2003-12-29 | 2007-06-28 | Hankins Carol A | Apparatus and method for guiding a medical device in multiple planes |
| CN202568473U (en) * | 2012-05-23 | 2012-12-05 | 荆友斌 | Crania-cerebral stereotaxic apparatus |
| WO2015054959A1 (en) * | 2013-10-18 | 2015-04-23 | 苏州瑞派宁科技有限公司 | Small animal position fixer |
| CN104546204A (en) * | 2015-01-21 | 2015-04-29 | 湖南中医药大学 | Method for accurately positioning Bregma point in rat brain stereotaxic surgery |
| CN107049543A (en) * | 2016-12-30 | 2017-08-18 | 中国科学院深圳先进技术研究院 | A kind of brain stereoscopic localized servicing unit, position indicator and brain localization method |
| CN209122525U (en) * | 2017-12-22 | 2019-07-19 | 河南医学高等专科学校 | Rat hippocampal puncture injection pilot pin |
| CN211750141U (en) * | 2019-11-07 | 2020-10-27 | 岭南师范学院 | Rat brain stereotaxic setting device |
| CN211271341U (en) * | 2019-11-20 | 2020-08-18 | 昆明医科大学 | Device for creating rat burn model |
| WO2021184462A1 (en) * | 2020-03-17 | 2021-09-23 | 中国科学院深圳先进技术研究院 | Brain stereotactic injection device |
| CN212679234U (en) * | 2020-05-14 | 2021-03-12 | 昆山市第二人民医院 | Traction repositor in ankle fracture operation |
| CN111643213A (en) * | 2020-06-12 | 2020-09-11 | 中国人民解放军空军军医大学 | Murine stereotactic skull leveling inspection and calibration device |
| CN213507428U (en) * | 2020-11-04 | 2021-06-22 | 苏州捷蓝智能设备有限公司 | Drive unit of sinker device of flat knitting machine |
| CN113008781A (en) * | 2021-03-08 | 2021-06-22 | 张涛 | Device is looked into at present to facing brick bonding strength for building supervision |
| CN217186574U (en) * | 2022-01-28 | 2022-08-16 | 河北医科大学 | Skull horizontal position leveling instrument for brain stereotaxic injection |
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