CN114366044A - Skin microvascular reactivity test system and method based on local pressure induction - Google Patents
Skin microvascular reactivity test system and method based on local pressure induction Download PDFInfo
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Abstract
The invention discloses a skin microvascular reactivity test system and method based on local pressure induction, and provides a skin microvascular reactivity test system based on local pressure induction, wherein a data acquisition module of the system comprises a pressure stimulation device and a skin blood flow detector, the influence of other interference factors participating in regulation is naturally shielded by keeping a pressure stimulation part consistent with a blood flow detection part, the blood flow regulation capability of skin microvasculature is accurately reflected, local pressure stimulation to a target position is realized through the pressure stimulation device, large stimulation and discomfort caused to a tester can be avoided, and inapplicable crowds such as hypertension and unstable vascular plaque patients can be avoided. The invention can test and obtain the blood flow characteristic signal by a local pressure induced reactive hyperemia mode under the condition of avoiding the discomfort of a tester, further can evaluate the blood flow regulation capability of the skin capillary, and can be widely applied to the technical field of biomedical engineering.
Description
Technical Field
The invention relates to the technical field of biomedical engineering, in particular to a system and a method for testing skin microvascular reactivity based on local pressure induction.
Background
The human blood vessel has the function of actively adjusting the size of a lumen, thereby regulating blood flow volume, wall shear force, blood pressure and other hemodynamic characteristics. Studies have shown that dysfunction of vascular regulation in the development of cardiovascular disease such as atherosclerosis occurs earlier than vascular structural lesions and plaque formation, and is the earliest detectable stage of cardiovascular disease. The addition of the evaluation of the vascular regulatory function on the basis of the traditional risk factors allows a more accurate assessment of the risk of cardiovascular diseases for the patient. The skin microcirculation is rich and is in the superficial layer, and is the most easy part for carrying out the blood vessel regulation function test.
Reactive hyperemia is a commonly used type of vascular function test that induces a hyperemic response change in blood vessels by introducing an external stimulus. The boom ischemia-induced reactive hyperemia (PORH) test is currently the most clinically used reactive hyperemia test protocol by placing an inflatable cuff on the upper arm and then recording changes in blood flow (or surrogate markers) to the forearm or finger after rest, cuff inflation, and cuff deflation. During the PORH test, inflation of the cuff causes brachial artery occlusion and ischemia of downstream tissues, and once the cuff is deflated, the compensatory increased blood flow often exceeds the normal blood flow level, generally the healthier the blood vessel is, the stronger the hyperaemic response is. Some of the currently used clinical and laboratory instruments are based on PORH protocols such as Endopat, produced by Itamar Medical, Israel, VENDYS, produced by Endothelix, USA, and the like.
The PORH test is used for causing brachial artery occlusion through cuff inflation, the occlusion time generally lasts for about 5 minutes, the pressurization value is generally higher than the systolic pressure of a tester by dozens of mmHg, the test condition has higher requirement on the ischemia tolerance of the tester, and the tester can generate uncomfortable feelings such as swelling, numbness, pain and the like; moreover, certain populations may have potential health risks for use, such as hypertension or patients with unstable plaque within the blood vessels.
In addition, the PORH scheme uses a cuff to pressurize the brachial artery of the upper arm, and detects the blood flow change in the forearm or fingertip, the pressure stimulation part is not consistent with the blood flow detection part, and the detection result includes the brachial artery regulation effect and the peripheral microcirculation regulation effect, so the interpretability of the test result is poor.
Disclosure of Invention
In view of this, embodiments of the present invention provide a system and a method for testing skin microvascular reactivity based on local pressure induction, which avoid causing great irritation and discomfort to a tester by means of local pressure induction, and can accurately position a detection location, thereby improving accuracy of a test result.
The first aspect of the embodiment of the invention provides a skin microvascular reactivity test system based on local pressure induction, which comprises a data acquisition module, an image preprocessing module and a signal analysis module, wherein the data acquisition module is used for acquiring blood flow image data, the image preprocessing module is used for processing the blood flow image data to obtain a blood flow signal, the signal analysis module is used for extracting characteristics of the blood flow signal, the data acquisition module comprises a pressure stimulation device and a skin blood flow detector, the pressure stimulation device comprises a bracket ring, a bracket head and a pressure control device, the bracket head is connected to the top of the bracket ring, the pressure control device is connected to the bottom of the bracket ring, the pressure stimulation device controls the bracket head to implement local pressure stimulation on a target position through the pressure control device, the blood flow detector is used for acquiring blood flow image data of the target position.
Optionally, the support head is movably connected to the support ring.
Optionally, the support head is a hollow structure, and the specification of the bottom section of the support head includes 0.5 square centimeter to 5 square centimeter.
Optionally, the bottom contact surface of the support head is made of a transparent material.
Optionally, the bottom of the bracket ring is provided with a connecting ring, and the connecting ring is used for connecting the bracket ring with the pressure control device.
Optionally, the pressure control device is a weight or a chest expander.
Optionally, the blood flow detector is a laser speckle contrast imager, a laser doppler imaging device, or an imaging photoplethysmograph.
The second aspect of the embodiments of the present invention provides a testing method using the system for testing skin microvascular reactivity based on local pressure induction according to the first aspect of the embodiments of the present invention, including:
fixing a bracket head connected to the top of a bracket ring in a pressure stimulation device in a data acquisition module at a target position;
controlling the support head to perform local pressure stimulation on the target position according to a pressure control device connected to the bottom of the support ring;
collecting blood flow image data of the target position according to a blood flow detector in the data collection module;
processing the blood flow image data to obtain a blood flow signal according to an image preprocessing module;
and according to a signal analysis module, carrying out feature extraction on the blood flow signal to obtain test information.
Optionally, the processing the blood flow image data to obtain a blood flow signal according to an image preprocessing module includes:
determining a region of interest in the blood flow image data according to an image preprocessing module;
carrying out spatial averaging processing on the image values in the region of interest to obtain a first blood flow signal;
and carrying out noise elimination processing according to the first blood flow signal to obtain a second blood flow signal.
Optionally, the performing, according to a signal analysis module, feature extraction on the blood flow signal to obtain test information includes:
extracting a blood flow baseline mean value and a blood flow rebound peak value according to the time history change of the blood flow signal;
calculating to obtain a measurement index according to the blood flow baseline mean value and the blood flow rebound peak value;
and obtaining test information according to the blood flow baseline mean value, the blood flow rebound peak value and the measurement index by combining with prior knowledge data.
The embodiment of the invention provides a skin microvascular reactivity testing system based on local pressure induction, which comprises a data acquisition module, an image preprocessing module and a signal analysis module, wherein the data acquisition module is used for acquiring blood flow image data, the image preprocessing module is used for processing the blood flow image data to obtain blood flow signals, the signal analysis module is used for extracting characteristics of the blood flow signals, the data acquisition module comprises a pressure stimulation device and a skin blood flow detector, the blood flow regulation capability of the skin microvasculature can be accurately reflected by keeping a pressure stimulation part in the testing process consistent with a blood flow detection part, the influence of the macrovascular or other factors participating in regulation is naturally shielded, the pressure stimulation device comprises a support ring, a support head and a pressure control device, the support head is connected to the top of the support ring, the pressure control device is connected to the bottom of the support ring, the pressure stimulation device controls the support head to perform local pressure stimulation on the target position through the pressure control device, the local pressure stimulation on the target position is realized through the pressure stimulation device, large stimulation and discomfort such as swelling, numbness and pain caused to a tester can be avoided, unsuitable people such as hypertension and unstable vascular plaque patients cannot exist, and the blood flow detector is used for collecting blood flow image data of the target position. The embodiment of the invention can test and obtain the blood flow characteristic signal by a local pressure induced reactive hyperemia mode under the condition of ensuring that a tester does not generate test discomfort, and further evaluate the blood flow regulating capacity of the skin micro-vessels.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts.
FIG. 1 is a schematic diagram of a system for testing cutaneous microvascular reactivity based on local pressure induction according to an embodiment of the present invention, which is enlarged in whole and in part;
FIG. 2 is a functional flow chart of a system for testing skin microvascular reactivity based on local pressure induction according to an embodiment of the present invention;
FIG. 3 is a graph illustrating a blood flow time history and characteristic values thereof collected by a system for testing skin microvascular reactivity based on local pressure induction according to an embodiment of the present invention;
fig. 4 is a schematic flowchart of a testing method using a system for testing skin microvascular reactivity based on local pressure induction according to an embodiment of the present invention.
Detailed Description
In order to make the objects, technical solutions and advantages of the present application more apparent, the present application is described in further detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the present application and are not intended to limit the present application.
In order to make the content and technical solution of the present application more clear, the related terms and meanings are explained as follows:
the blood vessel regulation function is as follows: the human blood vessel has a series of automatic regulation capabilities, and the hemodynamic parameters such as local pressure, shearing force, blood flow and the like in the blood vessel can be controlled and regulated through the change of the blood vessel diameter.
Reactive hyperemia test: a commonly used test for detecting the regulation function of blood vessels is to induce the reaction change of blood vessels to generate fast congestion by introducing external stimulation factors, such as mechanical stimulation, temperature stimulation, etc.
The structural function of the device of the invention is explained in detail below with the attached drawings of the specification:
referring to fig. 1, an embodiment of the present invention provides a system for testing skin microvascular reactivity based on local pressure induction, including a data acquisition module, an image preprocessing module and a signal analysis module, wherein the data acquisition module is used for acquiring blood flow image data, the image preprocessing module is used for processing blood flow image data to obtain blood flow signals, the signal analysis module is used for extracting characteristics of the blood flow signals, the blood flow detection device is characterized in that the data acquisition module comprises a pressure stimulation device and a skin blood flow detector, the pressure stimulation device comprises a support ring, a support head and a pressure control device, the support head is connected to the top of the support ring, the pressure control device is connected to the bottom of the support ring, the pressure stimulation device controls the support head to implement local pressure stimulation on a target position through the pressure control device, and the blood flow detector is used for acquiring blood flow image data of the target position.
Specifically, the pressure stimulation device of the data acquisition device applies local pressure stimulation to a target test position of a forearm of a tester to build an environmental condition of data test, then blood flow image data of the target test position is acquired through a blood flow detector of the data acquisition device, the acquired blood flow image data is transmitted to the image preprocessing module, the blood flow image data is processed through the image preprocessing module to obtain blood flow signals, the processed blood flow signals are further transmitted to the signal analysis module, and the blood flow signals are subjected to feature extraction through the signal analysis module. Finally, according to the extracted characteristic data and the related priori knowledge, whether the blood flow regulation function of the skin micro-vessels is normal or not can be comprehensively judged.
In some embodiments, the support head is movably connected to the top of the support ring, that is, the support head is a replaceable component, and can be replaced with a support head of a corresponding specification according to different test requirements.
In some embodiments, the stent head is a hollow structure, the area specification of the cross section of the bottom of the stent head, which is in contact with the test site for performing the local pressure stimulation, includes 0.5 square centimeter to 5 square centimeters, the shape of the contact surface of the stent head can be circular, square or other special shapes, and the stent head with the corresponding specification can be correspondingly replaced according to different test requirements.
In some embodiments, the contact surface of the stent head and the bottom of the test portion for applying local pressure stimulation is made of transparent materials, including PVC, glass, etc., the collection lens of the blood flow detector directly collects blood flow data of the test portion for applying local pressure stimulation through the hollow structure of the stent head, the collection lens of the blood flow detector is preferably located at a distance of 30cm right above the test portion, and correspondingly, the contact surface of the bottom of the stent head is a transparent lens, so that the collection device of the blood flow detector can conveniently collect blood flow image data with clear imaging.
In some embodiments, the bottom of the support ring is provided with a connection ring, the pressure control device is connected to the support ring through the connection ring, and the support head is further controlled by the support ring to apply local pressure stimulation to the target position of the test.
In some embodiments, the pressure control device can be a weight or a chest expander, and the pressure control of an accurate value is realized by increasing or decreasing the number or weight of the weights or setting the force value of the chest expander, so that accurate local pressure stimulation is realized.
In some embodiments, the blood flow detector is a laser speckle contrast imager, a laser doppler imaging device, or an imaging photoplethysmograph.
In some embodiments, referring to fig. 2, the local pressure-induced cutaneous microvascular reactivity test system of the present invention is specifically composed and functions as follows:
the system is composed of a data acquisition module, an image preprocessing module and a signal analysis module.
The data acquisition module consists of a pressure stimulation device and a skin blood flow detector.
The pressure stimulation device mainly comprises a metal annular support and load weights below the annular support, wherein a round hole is formed below the support and used for hooking the weights; the holder head is designed as a hollow cylinder, the bottom (i.e. the skin contact part) of which covers a circular, flat transparent lens, with a diameter of about 1cm to 2 cm.
The skin blood flow detector can perform non-contact continuous monitoring on skin blood flow in a certain visual field range, obtain a sequence blood flow graph or blood flow video, and preferentially select a laser speckle contrast imager (or laser Doppler imaging equipment, an imaging photoplethysmography instrument and the like).
And the image preprocessing module is connected with the data acquisition module and is used for deriving a smooth one-dimensional blood flow signal from the original two-dimensional blood flow image sequence. The module firstly selects an interested Region (ROI) from a two-dimensional blood flow image, then performs spatial averaging processing on an image value in the ROI and extracts a one-dimensional blood flow signal; finally, a wavelet filtering method is adopted to further eliminate noise and high-frequency fluctuation in the extracted blood flow signals, so that smooth one-dimensional blood flow signals are derived.
And the signal analysis module is connected with the image preprocessing module and is used for carrying out feature extraction and skin micro-vessel regulation function evaluation on the blood flow signals. As shown in FIG. 3, the signal analysis module will extract the baseline mean value w of the skin blood flow before the local pressure is applied according to the time-varying changes of the blood flow signal0Blood flow rebound peak value w after release of local skin pressure2And calculating the area a under the curveAUC. Wherein a isAUCUtilizing blood flow signal rebound change curve and skin blood flow baseline mean value w after local pressure release0The area enclosed by the two parts is obtained. Obtaining the characteristic value, and then selecting healthy people w in the same age group2，w2-w0，w2/w0，aAUCThe statistical data of (2) is used as a reference value range, and compared with a test result, whether the blood flow regulation function of the skin micro-vessel is normal or not is evaluated according to the comparison result.
An embodiment of the present invention provides a testing method using the system embodiment, as shown in fig. 4, the method includes:
fixing a bracket head connected to the top of a bracket ring in a pressure stimulation device in a data acquisition module at a target position;
controlling the support head to perform local pressure stimulation on a target position according to a pressure control device connected to the bottom of the support ring;
collecting blood flow image data of a target position according to a blood flow detector in a data collection module;
processing blood flow image data to obtain a blood flow signal according to an image preprocessing module;
and according to the signal analysis module, carrying out feature extraction on the blood flow signal to obtain test information.
In some embodiments, processing the blood flow image data according to an image preprocessing module to obtain a blood flow signal includes:
determining an interested area in the blood flow image data according to an image preprocessing module;
carrying out spatial averaging processing on the image value in the region of interest to obtain a first blood flow signal;
and carrying out noise elimination processing according to the first blood flow signal to obtain a second blood flow signal.
Specifically, the image preprocessing module firstly selects a region of interest (ROI) from blood flow image data (i.e. an original two-dimensional blood flow image), and then performs spatial averaging on an image value in the ROI to extract a one-dimensional blood flow signal (i.e. a first blood flow signal); finally, a wavelet filtering method is adopted to further eliminate noise and high-frequency fluctuation in the extracted blood flow signal, so that a smooth one-dimensional blood flow signal (namely second blood flow information) is derived.
In some embodiments, performing feature extraction on the blood flow signal according to the signal analysis module to obtain test information includes:
extracting a blood flow baseline mean value and a blood flow rebound peak value according to the time history change of the blood flow signal;
calculating to obtain a measurement index according to the blood flow baseline mean value and the blood flow rebound peak value;
and obtaining test information according to the blood flow baseline mean value, the blood flow rebound peak value and the measurement index by combining with the prior knowledge data.
Specifically, referring to fig. 3, the signal analysis module extracts the baseline mean value w of the skin blood flow before the local pressure is applied according to the time-varying changes of the blood flow signal0(i.e., baseline mean blood flow), peak rebound of blood flow w after release of local pressure on the skin2(i.e., peak blood flow rebound) and calculate the area under the curve aAUC(i.e., a measure). Wherein a isAUCUtilizing blood flow signal rebound change curve and skin blood flow baseline mean value w after local pressure release0The area enclosed by the two parts is obtained. Obtaining the characteristic value, and then selecting healthy people w in the same age group2，w2-w0，w2/w0，aAUCThe statistical data of (2) is used as a reference value range, and compared with a test result, whether the blood flow regulation function of the skin micro-vessel is normal or not is evaluated according to the comparison result.
In some embodiments, the above-mentioned testing method using the system for testing skin microvascular reactivity based on local pressure induction can be implemented by the following procedures:
1. the test subjects need to meet the test conditions. Subjects remained without eating, taking medications, smoking, drinking, and other functional drinks 2 hours prior to testing, without significant exercise; after entering the collection room, the patient sits still and has a rest for 15 minutes to wait for testing.
2. Skin blood flow baseline collection. The subject placed the forearm of one arm flat on the armrest of the chair with the palm facing down. An imaging target area is selected at a position near the wrist of the forearm and marked by a pen, then a skin blood flow detection instrument is started, a lens is aligned to the skin of the target area, and blood flow images are continuously acquired for 5 to 10 minutes. The forearm remained unmoved throughout the test.
3. Topical pressure and blood flow collection are applied to the skin. The annular support of the pressure stimulation device is sleeved on the forearm, so that the support head is aligned to the skin of the marked imaging target area, the planar lens at the bottom of the support head is tightly attached to the skin under the action of gravity, and then a certain mass weight is hooked below the support, so that: (weight + weight of stent)/area of bottom surface of stent head 180mmHg (i.e. 24 kpa); after the pressure stimulation device was placed, blood flow images were continuously acquired for 5 minutes on the same skin area.
4. And (5) collecting blood flow after pressure is released. The pressure stimulation device (ring support and weight) was removed from the forearm and blood flow images were taken continuously for 10 minutes on the same skin area.
5. And introducing the collected blood flow sequence images or videos into an image preprocessing module, averaging the blood flow values of the target area to form a one-dimensional blood flow signal, performing noise reduction processing, and outputting a smooth blood flow signal w (t).
6. The smooth blood flow signal w (t) is led into a signal analysis module, as shown in fig. 3, and the skin blood flow baseline mean value w is respectively extracted0Blood flow rebound peak value w after release of local skin pressure2Calculating the area a under the curveAUC。
7. The healthy people w in the same age group2，w2-w0，w2/w0，aAUCThe statistical data of (2) is used as a reference value range, and compared with a test result, whether the blood flow regulation function of the skin micro-vessel is normal or not is evaluated according to the comparison result.
The contents of the embodiment of the system of the invention are all applicable to the embodiment of the method, the functions specifically realized by the embodiment of the method are the same as the functions of the embodiment of the system, and the beneficial effects achieved by the embodiment of the method are also the same as the beneficial effects achieved by the embodiment of the device.
In summary, the present invention provides a system and a method for testing cutaneous microvascular reactivity based on local pressure induction, which are directed to the technical defects of the conventional PORH test scheme that the discomfort is easily caused to the tester and the interpretability of the test result is poor. The data acquisition device comprises a pressure stimulation device and a blood flow detector, and firstly, the data acquisition device can carry out accurate local pressure stimulation on a target test position through the pressure stimulation device, and cannot cause large stimulation and discomfort such as swelling, numbness, pain and the like to a tester. There are no people who are not suitable for the treatment, such as hypertension and unstable vascular plaque patients. In addition, the blood flow detector and the pressure stimulation device jointly form the data acquisition device, so that the pressure stimulation part is consistent with the blood flow detection part when the reactivity test is carried out, the blood flow regulation capability of the skin micro-vessels can be accurately reflected, and the influence of the large vessels or other factors participating in regulation is naturally shielded. The invention can evaluate the blood flow regulation capability of the skin capillary by a local pressure induced reactive hyperemia mode under the condition of ensuring that a tester does not generate test discomfort.
In alternative embodiments, the functions/acts noted in the block diagrams may occur out of the order noted in the operational illustrations. For example, two blocks shown in succession may, in fact, be executed substantially concurrently, or the blocks may sometimes be executed in the reverse order, depending upon the functionality/acts involved. Furthermore, the embodiments presented and described in the flow charts of the present invention are provided by way of example in order to provide a more thorough understanding of the technology. The disclosed methods are not limited to the operations and logic flows presented herein. Alternative embodiments are contemplated in which the order of various operations is changed and in which sub-operations described as part of larger operations are performed independently.
In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
While embodiments of the invention have been shown and described, it will be understood by those of ordinary skill in the art that: various changes, modifications, substitutions and alterations can be made to the embodiments without departing from the principles and spirit of the invention, the scope of which is defined by the claims and their equivalents.
While the preferred embodiments of the present invention have been illustrated and described, it will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.
Claims (10)
1. A skin microvascular reactivity test system based on local pressure induction comprises a data acquisition module, an image preprocessing module and a signal analysis module, the data acquisition device is used for acquiring blood flow image data, the image preprocessing module is used for processing the blood flow image data to obtain blood flow signals, the signal analysis module is used for extracting characteristics of the blood flow signals, it is characterized in that the data acquisition module comprises a pressure stimulation device and a skin blood flow detector, the pressure stimulation device comprises a bracket ring, a bracket head and a pressure control device, the bracket head is connected with the top of the bracket ring, the pressure control device is connected to the bottom of the support ring, the pressure stimulation device controls the support head to perform local pressure stimulation on a target position through the pressure control device, and the blood flow detector is used for collecting blood flow image data of the target position.
2. The system for testing cutaneous microvascular reactivity based on local pressure induction according to claim 1, wherein the stent head is movably connected to the stent ring.
3. The system for testing cutaneous microvascular reactivity based on local pressure induction according to claim 2, wherein the stent head is a hollow structure, and the specification of the bottom section of the stent head comprises 0.5 square centimeters to 5 square centimeters.
4. The system for testing cutaneous microvascular reactivity based on local pressure induction according to claim 3, wherein the bottom contact surface of the stent head is made of a transparent material.
5. The system for testing cutaneous microvascular reactivity based on local pressure induction according to claim 1, wherein the bottom of the stent ring is provided with a connection ring, and the connection ring is used for connecting the stent ring with the pressure control device.
6. The system for testing cutaneous microvascular reactivity based on local pressure induction according to claim 1, wherein the pressure control device is a weight or a chest expander.
7. The system for testing cutaneous microvascular reactivity based on local pressure induction according to claim 1, wherein the blood flow detector is a laser speckle contrast imager, a laser doppler imaging device or an imaging photoplethysmograph.
8. A test method using the system for testing cutaneous microvascular reactivity based on local pressure induction according to claim 1, comprising:
fixing a bracket head connected to the top of a bracket ring in a pressure stimulation device in a data acquisition module at a target position;
controlling the support head to perform local pressure stimulation on the target position according to a pressure control device connected to the bottom of the support ring;
collecting blood flow image data of the target position according to a blood flow detector in the data collection module;
processing the blood flow image data to obtain a blood flow signal according to an image preprocessing module;
and according to a signal analysis module, carrying out feature extraction on the blood flow signal to obtain test information.
9. The testing method according to claim 8, wherein the processing the blood flow image data into a blood flow signal according to an image preprocessing module comprises:
determining a region of interest in the blood flow image data according to an image preprocessing module;
carrying out spatial averaging processing on the image values in the region of interest to obtain a first blood flow signal;
and carrying out noise elimination processing according to the first blood flow signal to obtain a second blood flow signal.
10. The testing method of claim 8, wherein the performing feature extraction on the blood flow signal according to a signal analysis module to obtain test information comprises:
extracting a blood flow baseline mean value and a blood flow rebound peak value according to the time history change of the blood flow signal;
calculating to obtain a measurement index according to the blood flow baseline mean value and the blood flow rebound peak value;
and obtaining test information according to the blood flow baseline mean value, the blood flow rebound peak value and the measurement index by combining with prior knowledge data.
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