CN114364701A - 密封蛋白18抗体和治疗癌症的方法 - Google Patents

密封蛋白18抗体和治疗癌症的方法 Download PDF

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CN114364701A
CN114364701A CN202080062500.1A CN202080062500A CN114364701A CN 114364701 A CN114364701 A CN 114364701A CN 202080062500 A CN202080062500 A CN 202080062500A CN 114364701 A CN114364701 A CN 114364701A
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seq
antigen binding
binding protein
amino acid
antibody
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D·康克林
M·S·麦克德莫特
N·A·奥布赖恩
M·J·帕拉佐洛
D·斯拉蒙
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University of California San Diego UCSD
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CN202080062500.1A 2019-07-17 2020-07-17 密封蛋白18抗体和治疗癌症的方法 Pending CN114364701A (zh)

Applications Claiming Priority (3)

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US201962875416P 2019-07-17 2019-07-17
US62/875,416 2019-07-17
PCT/US2020/042573 WO2021011885A1 (en) 2019-07-17 2020-07-17 Claudin18 antibodies and methods of treating cancer

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US (3) US12345709B2 (https=)
EP (1) EP3999548A4 (https=)
JP (2) JP2022541435A (https=)
KR (2) KR102777693B1 (https=)
CN (1) CN114364701A (https=)
AU (2) AU2020313978B2 (https=)
BR (1) BR112022000371A2 (https=)
CA (1) CA3146665A1 (https=)
IL (2) IL289663B2 (https=)
MX (1) MX2022000652A (https=)
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JP2022541435A (ja) 2019-07-17 2022-09-26 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア クローディン18抗体及びがんを処置する方法
KR20230079096A (ko) * 2020-09-30 2023-06-05 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 항체-약물 접합체를 포함하는 약제학적 조성물 및 약제학적 조성물의 용도
JP2024511319A (ja) 2021-03-09 2024-03-13 ゼンコア インコーポレイテッド Cd3及びcldn6に結合するヘテロ二量体抗体
CN117157105A (zh) 2021-05-08 2023-12-01 荣昌生物制药(烟台)股份有限公司 一种抗Claudin18.2抗体及其抗体药物偶联物
JP2024523166A (ja) * 2021-06-15 2024-06-28 ゼンコア インコーポレイテッド クローディン18.2及びcd3に結合するヘテロ二量体抗体
WO2022268200A1 (zh) * 2021-06-25 2022-12-29 信达生物制药(苏州)有限公司 针对密蛋白18.2的抗体及其用途
CR20240124A (es) * 2021-08-09 2024-08-06 Harbour Biomed Shanghai Co Ltd Anticuerpo dirigido contra cldn18.2, anticuerpo biespecífico y el uso de estos
CN118139888A (zh) * 2021-11-05 2024-06-04 正大天晴药业集团股份有限公司 抗cldn18.2抗体及其用途
US20250249125A1 (en) * 2022-04-08 2025-08-07 Fred Hutchison Cancer Center Anti-cd90 antibodies, binding fragments, and uses thereof
KR20250069817A (ko) * 2022-06-03 2025-05-20 라노바 메디신즈 리미티드 Pd-1 또는 pd-l1 억제제 및 클라우딘 18.2를 표적화하는 항체-약물 콘쥬게이트를 사용한 암 치료
TW202426059A (zh) * 2022-11-30 2024-07-01 大陸商正大天晴藥業集團股份有限公司 抗cldn18.2抗體藥物偶聯物及其藥物組合物和用途
KR20250120305A (ko) * 2022-12-14 2025-08-08 아스텔라스 파마 유럽 비.브이. Cldn18.2 및 cd3에 결합하는 2중 특이성 결합제와 면역 체크포인트 저해제를 수반한 조합 요법
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