CN114354978A - Device for preventing surface of atomic force microscope probe from generating bubbles and using method - Google Patents
Device for preventing surface of atomic force microscope probe from generating bubbles and using method Download PDFInfo
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- CN114354978A CN114354978A CN202111365535.5A CN202111365535A CN114354978A CN 114354978 A CN114354978 A CN 114354978A CN 202111365535 A CN202111365535 A CN 202111365535A CN 114354978 A CN114354978 A CN 114354978A
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- atomic force
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- 239000000523 sample Substances 0.000 title claims abstract description 92
- 238000000034 method Methods 0.000 title claims description 16
- 239000007788 liquid Substances 0.000 claims abstract description 59
- 238000005470 impregnation Methods 0.000 claims abstract description 28
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 26
- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract description 15
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract description 15
- -1 polydimethylsiloxane Polymers 0.000 claims abstract description 15
- 239000003960 organic solvent Substances 0.000 claims abstract description 13
- 239000012153 distilled water Substances 0.000 claims abstract description 7
- JEGUKCSWCFPDGT-UHFFFAOYSA-N h2o hydrate Chemical compound O.O JEGUKCSWCFPDGT-UHFFFAOYSA-N 0.000 claims abstract description 7
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 12
- 238000007654 immersion Methods 0.000 claims description 12
- 238000007598 dipping method Methods 0.000 claims description 7
- 238000002474 experimental method Methods 0.000 claims description 4
- 239000012530 fluid Substances 0.000 claims description 3
- 150000001298 alcohols Chemical class 0.000 claims description 2
- 238000002791 soaking Methods 0.000 description 16
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 12
- 230000008569 process Effects 0.000 description 5
- 238000002803 maceration Methods 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 238000007796 conventional method Methods 0.000 description 3
- 238000010586 diagram Methods 0.000 description 3
- 238000001035 drying Methods 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
- 238000004630 atomic force microscopy Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000000861 blow drying Methods 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 229940008099 dimethicone Drugs 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000002209 hydrophobic effect Effects 0.000 description 1
- 238000003384 imaging method Methods 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 229920002545 silicone oil Polymers 0.000 description 1
- 210000003454 tympanic membrane Anatomy 0.000 description 1
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- Length Measuring Devices With Unspecified Measuring Means (AREA)
- Microscoopes, Condenser (AREA)
Abstract
The invention discloses a device for preventing bubbles from being generated on the surface of an atomic force microscope probe, which comprises a box body and a clamp, wherein the top of the box body is provided with a coordination hole, and the clamp is positioned in the outer circumferential direction of the coordination hole and is used for fixing a needle tip seat provided with the atomic force microscope probe above the coordination hole; the box body is also provided with a flow guide inlet and a flow guide outlet, the flow guide inlet and the flow guide outlet are respectively communicated with the coordination hole, the first impregnation liquid and the second impregnation liquid sequentially flow in from the flow guide inlet, and flow out from the flow guide outlet after reaching the coordination hole to impregnate the atomic force microscope probe on the needle tip seat, and the first impregnation liquid is an organic solvent compatible with polydimethylsiloxane and water; the second impregnation liquid is water or distilled water. The invention has the advantages of simple structure and simple and convenient operation.
Description
Technical Field
The invention relates to the field of atomic force microscope probe processing, in particular to a device for preventing bubbles from being generated on the surface of an atomic force microscope probe and a using method.
Background
Atomic force microscopy has received extensive attention in various fields since its invention in 1986, and has yielded tremendous technological advances based on this device over the past few decades. The atomic force microscope measures the interaction between the probe and the surface of the sample by detecting the deflection amount of the probe, and further calculates the detailed information which is wanted to be obtained by the experiment. Due to its high force and displacement sensitivity and the ability to operate in a variety of environments (air, liquid, vacuum, etc.). Due to its excellent spatial resolution, atomic force microscopy is used not only for imaging the surface of a sample, but also for probing the local chemistry and mechanics between samples.
It can be seen from the working principle that the resolution of the atomic force microscope depends on the shape, elastic modulus, etc. of the atomic force microscope probe. However, during transportation and storage, the base material of the packaging box is polydimethylsiloxane (commonly called dimethicone or silicone oil), which makes the surface of the atomic force microscope probe wrap a layer of polydimethylsiloxane. Polydimethylsiloxane is a hydrophobic class of organosilicon material and the atomic force microscope probes are small in size, typically in the 100-200 micron range.
Due to the two reasons, when the atomic force microscope probe is put into a liquid environment for use, a bubble is easily formed to wrap the atomic force microscope probe. Since the existing device cannot avoid the generation of bubbles, the generated bubbles are very small and are difficult to remove by a user. The most common practice is to remove the afm probe, blow it dry it, and replace it in the liquid. This method does not ensure that bubbles do not re-form on the afm probe once again placed in the liquid. Alternatively, the bubbles are removed by a method of drying the air bubbles by means of a tympanic membrane after the bubbles have been generated. Namely: and taking out the atomic force microscope probe with the air bubbles, and drying the liquid on the surface of the probe by blowing through an aurilave. Then, the atomic force microscope probe was used by being immersed in the liquid according to the above method.
Therefore, the following technical problems exist in the prior art: (1) the generation of bubbles cannot be avoided actively, the conventional method is to treat the generated bubbles, and no preventive measures are taken to prevent the generation of bubbles when the atomic force microscope probe is put into a liquid environment for use; (2) in the conventional method, the excessive air flow in the blow-drying process easily causes the deformation of the atomic force microscope probe, thereby causing the damage of the atomic force microscope probe; (3) the conventional method cannot ensure that the atomic force microscope probe cannot generate bubbles again after the atomic force microscope probe is dried, and the bubbles still can be formed when the atomic force microscope probe is put into a liquid environment again after being dried; (4) the operation is troublesome and time-consuming.
Disclosure of Invention
The invention aims to overcome the defects of the prior art and provides a device which is simple in structure and convenient to operate and can avoid bubbles on the surface of an atomic force microscope probe and a using method thereof.
In order to solve the technical problems, the invention adopts the following technical scheme:
a device for preventing bubbles from being generated on the surface of an atomic force microscope probe comprises a box body and a clamp, wherein a coordination hole is formed in the top of the box body, and the clamp is located in the outer circumferential direction of the coordination hole and used for fixing a needle tip seat provided with the atomic force microscope probe above the coordination hole; the box body is also provided with a flow guide inlet and a flow guide outlet, the flow guide inlet and the flow guide outlet are respectively communicated with the coordination hole, first impregnation liquid and second impregnation liquid sequentially flow in from the flow guide inlet, and flow out from the flow guide outlet after reaching the position of the coordination hole to impregnate the atomic force microscope probe on the needle tip seat, and the first impregnation liquid is an organic solvent compatible with polydimethylsiloxane and water; the second impregnation liquid is water or distilled water.
As a further improvement to the above technical solution:
the clamp is arranged in a central symmetry mode around the coordination hole.
The fixture comprises a clamping part and a fixing part, wherein the clamping part is used for clamping the needle point seat, the fixing part is used for fixing the fixture, and the clamping part is rotatable around the fixing part.
The clamping part and the fixing part are vertically arranged.
The flow guide inlet and the flow guide outlet are symmetrically arranged on two side walls of the box body.
The device also comprises a flow rate control device for controlling the flow rate of the impregnation fluid. When the first impregnation liquid is acetone, the flow rate control device controls the upper limit value of the flow rate of the first impregnation liquid to be 50 cm/min.
The flow rate control device is an injector or a flow rate valve.
As a general inventive concept, the present invention also provides a method for using an apparatus for preventing bubbles from being generated on a surface of an atomic force microscope probe, comprising the steps of:
s1, fixing the needle tip seat with the atomic force microscope probe on the box body by a clamp;
s2, opening a diversion inlet, and introducing a first immersion liquid for immersing the needle tip seat provided with the atomic force microscope probe, wherein the first immersion liquid is an organic solvent compatible with polydimethylsiloxane and water;
s3, opening the diversion outlet, and introducing a second immersion liquid into the diversion inlet for immersing the needle tip seat provided with the atomic force microscope probe, wherein the second immersion liquid is water or distilled water;
and S4, removing the needle tip seat provided with the atomic force microscope probe, and using the atomic force microscope probe for subsequent experiments.
The first impregnation liquid is acetone or alcohol compounds.
The upper limit value of the flow speed of the first impregnation liquid is 50 cm/min.
Compared with the prior art, the invention has the advantages that:
the device for avoiding the generation of bubbles on the surface of the atomic force microscope probe and the use method thereof have simple structure and simple and convenient operation, the needle tip seat with the atomic force microscope probe is integrally fixed on the device and is sequentially soaked by the first soaking liquid and the second soaking liquid, the first soaking liquid is an organic solvent compatible with polydimethylsiloxane and water, the polydimethylsiloxane on the surface of the probe can be taken away, no bubbles are generated on the surface of the probe in the soaking process, the first soaking liquid is compatible with water, so that the first soaking liquid on the surface of the probe can be taken away when the probe is soaked by the second soaking liquid, and no bubbles are generated on the surface of the probe in the soaking process. The surface of the probe after the dipping treatment is coated by water, so that bubbles can be actively prevented from being generated on the surface of the probe due to the surface tension when the probe is used in a liquid environment.
Drawings
FIG. 1 is a schematic diagram of the structure of the apparatus of the present invention.
Fig. 2 is a top view of the apparatus of the present invention.
Fig. 3 is a sectional view taken along line B-B of fig. 2.
FIG. 4 is a schematic diagram of the atomic force microscope probe after being processed by the device of the present invention.
FIG. 5 is a schematic diagram of the state of use of an AFM probe that has not been processed by the apparatus of the present invention.
The reference numerals in the figures denote: 1. a box body; 11. a registration hole; 12. a flow guide inlet; 13. a diversion outlet; 2. and (4) clamping.
Detailed Description
The invention will be described in further detail below with reference to the drawings and specific examples. Unless otherwise specified, the instruments or materials employed in the present invention are commercially available.
Example 1:
as shown in fig. 1 to 3, the apparatus for preventing bubbles from being generated on the surface of an afm probe of the present embodiment includes a box 1 and a fixture 2, wherein a matching hole 11 is formed at the top of the box 1, and the fixture 2 is located in the outer circumferential direction of the matching hole 11 and is used for fixing a tip seat with the afm probe above the matching hole 11; the box body 1 is also provided with a flow guide inlet 12 and a flow guide outlet 13, the flow guide inlet 12 and the flow guide outlet 13 are respectively communicated with the coordination hole 11, a first impregnation liquid and a second impregnation liquid sequentially flow in from the flow guide inlet 12, and flow out from the flow guide outlet 13 after reaching the coordination hole 11 and impregnating an atomic force microscope probe on a needle tip seat, wherein the first impregnation liquid is an organic solvent compatible with polydimethylsiloxane and water; the second impregnation liquid is water or distilled water.
The invention relates to a device for avoiding bubbles on the surface of an atomic force microscope probe, which is characterized in that a needle point seat with the atomic force microscope probe is integrally fixed on the device and is sequentially soaked by a first soaking liquid and a second soaking liquid, wherein the first soaking liquid is an organic solvent compatible with polydimethylsiloxane and water, the polydimethylsiloxane on the surface of the probe can be taken away, no bubbles are generated on the surface of the probe in the soaking process, the first soaking liquid is compatible with water, so that the first soaking liquid on the surface of the probe can be taken away when the probe is soaked by the second soaking liquid, and no bubbles are generated on the surface of the probe in the soaking process. The surface of the probe after the dipping treatment is coated by water, so that bubbles can be prevented from being generated on the surface of the probe due to the surface tension when the probe is used in a liquid environment.
The jigs 2 are arranged centrally symmetrically with respect to the registration holes 11. Because the existing needle point seat is basically cylindrical, the two clamps 2 are used for symmetrically clamping the needle point seat, and the stable clamping of the needle point seat is more facilitated.
The clamping part and the fixing part are vertically arranged.
The diversion inlet 12 and the diversion outlet 13 are symmetrically arranged on two side walls of the box body 1. Flow guide inlet 12 and flow guide outlet 13 set up on the lateral wall of box 1, and coordination hole 11 sets up at box 1 top, and from this, first maceration extract and second maceration extract all can not directly impact on the needle point seat when getting into box 1 on, and whole box 1 is full of gradually to the maceration extract below coordination hole 11, avoids the probe to be impacted and receive the damage by the maceration extract is direct. When the first impregnation liquid is an organic solvent with a relatively high viscosity, such as acetone, the apparatus further comprises a flow rate control device (not shown in the figure) for controlling the flow rate of the impregnation liquid. Flow rate control devices are respectively arranged at the diversion inlet 12 and the diversion outlet 13 and are used for controlling the flow rate of the first impregnation liquid; the flow rate control devices respectively arranged at the diversion inlet 12 and the diversion outlet 13 effectively control the deformation of the probe caused by the change of temperature or pressure due to high viscosity and over-high flow rate of the organic solvent.
The flow rate control device is an injector or a flow rate control valve.
The use method of the device for avoiding bubbles on the surface of the atomic force microscope probe comprises the following steps:
s1, fixing the tip seat with the atomic force microscope probe on the box body 1 by the clamp 2;
s2, opening the diversion inlet 12 and introducing a first immersion liquid for immersing the needle tip seat provided with the atomic force microscope probe, wherein the first immersion liquid and the polydimethylsiloxane are similar compatible organic solvents;
s3, opening the diversion outlet 13, and introducing a second immersion liquid into the diversion inlet 12 for immersing the needle tip seat provided with the atomic force microscope probe, wherein the second immersion liquid is water or distilled water; in this embodiment, the flow rate control devices at the diversion inlet 12 and the diversion outlet 13 are controlled so that the second impregnation fluid fills the entire tank.
And S4, taking down the needle tip seat provided with the atomic force microscope probe, and directly using the atomic force microscope probe for subsequent experiments without drying or airing the atomic force microscope probe.
In this embodiment, the first immersion liquid is acetone, and in other embodiments, the first immersion liquid is an alcohol compound, such as methanol, ethanol, isopropanol, and the like, which can achieve the same or similar technical effects.
When the first dipping solution is an organic solvent with high viscosity such as acetone, the upper limit value of the flow speed of the first dipping solution is 50cm/min, so that the probe can be prevented from deforming because of too high flow speed when the probe is dipped by using an organic solvent with high viscosity.
As shown in fig. 4, the atomic force microscope probe after being processed by the apparatus of the present invention is schematically shown in the using state, in the figure, no bubbles are generated on the surface of the probe, and bubbles are generated on the surface of the untreated probe (as shown in fig. 5).
Although the present invention has been described with reference to the preferred embodiments, it is not intended to be limited thereto. Those skilled in the art can make numerous possible variations and modifications to the present invention, or modify equivalent embodiments to equivalent variations, without departing from the scope of the invention, using the teachings disclosed above. Therefore, any simple modification, equivalent change and modification made to the above embodiments according to the technical spirit of the present invention should fall within the protection scope of the technical scheme of the present invention, unless the technical spirit of the present invention departs from the content of the technical scheme of the present invention.
Claims (10)
1. The utility model provides a device for avoid atomic force microscope probe surface to produce bubble which characterized in that: the probe comprises a box body (1) and a clamp (2), wherein a matching hole (11) is formed in the top of the box body (1), and the clamp (2) is located in the outer circumferential direction of the matching hole (11) and used for fixing a needle tip seat provided with an atomic force microscope probe above the matching hole (11);
the box body (1) is further provided with a flow guide inlet (12) and a flow guide outlet (13), the flow guide inlet (12) and the flow guide outlet (13) are respectively communicated with the matching hole (11), first impregnation liquid and second impregnation liquid sequentially flow in from the flow guide inlet (12), flow out from the flow guide outlet (13) after reaching the matching hole (11) to impregnate the atomic force microscope probe on the needle tip seat, and the first impregnation liquid is an organic solvent compatible with polydimethylsiloxane and water; the second impregnation liquid is water or distilled water.
2. The apparatus for avoiding bubbles on the surface of the probe of atomic force microscope as claimed in claim 1, wherein: the clamp (2) is arranged in a central symmetry mode relative to the matching hole (11).
3. The apparatus for avoiding bubbles on the surface of the probe of atomic force microscope as claimed in claim 1, wherein: the fixture (2) comprises a clamping part and a fixing part, the clamping part is used for clamping the needle point seat, the fixing part is used for fixing the fixture (2), and the clamping part is rotatable around the fixing part.
4. The apparatus for avoiding bubbles on the surface of the probe of atomic force microscope as claimed in claim 3, wherein: the clamping part and the fixing part are vertically arranged.
5. The apparatus for avoiding bubbles on the surface of the probe of atomic force microscope as claimed in claim 1, wherein: the flow guide inlet (12) and the flow guide outlet (13) are symmetrically arranged on two side walls of the box body (1).
6. The apparatus for avoiding bubbles on the surface of the probe of atomic force microscope as claimed in claim 1, wherein: the device also comprises a flow rate control device for controlling the flow rate of the impregnation fluid.
7. The apparatus for avoiding bubbles on the surface of the probe of atomic force microscope as claimed in claim 6, wherein: the flow rate control device is an injector or a flow rate valve.
8. Use of the device for preventing bubbles from being generated on the surface of the probe of the atomic force microscope according to any one of claims 1 to 7, wherein the device comprises: the method comprises the following steps:
s1, fixing the needle tip seat provided with the atomic force microscope probe on the box body (1) by using a clamp (2);
s2, opening a diversion inlet (12) and introducing a first dipping solution for dipping the needle tip seat filled with the atomic force microscope probe, wherein the first dipping solution is an organic solvent compatible with polydimethylsiloxane and water;
s3, opening the diversion outlet (13), introducing a second immersion liquid into the diversion inlet (12) for immersing the needle tip seat provided with the atomic force microscope probe, wherein the second immersion liquid is water or distilled water;
and S4, removing the needle tip seat provided with the atomic force microscope probe, and using the atomic force microscope probe for subsequent experiments.
9. Use according to claim 8, characterized in that: the first impregnation liquid is acetone or alcohol compounds.
10. Use according to claim 9, characterized in that: the upper limit value of the flow speed of the first impregnation liquid is 50 cm/min.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111365535.5A CN114354978B (en) | 2021-11-17 | 2021-11-17 | Device for avoiding bubble generation on surface of atomic force microscope probe and use method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111365535.5A CN114354978B (en) | 2021-11-17 | 2021-11-17 | Device for avoiding bubble generation on surface of atomic force microscope probe and use method |
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| CN114354978B CN114354978B (en) | 2024-04-19 |
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|---|---|---|---|---|
| JPH0666511A (en) * | 1992-08-19 | 1994-03-08 | Nikon Corp | Preserving mechanism for metal probe for scanning type microscope |
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2021
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