CN114340657A - 新型crispr dna靶向酶及系统 - Google Patents

新型crispr dna靶向酶及系统 Download PDF

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Publication number
CN114340657A
CN114340657A CN202080062919.7A CN202080062919A CN114340657A CN 114340657 A CN114340657 A CN 114340657A CN 202080062919 A CN202080062919 A CN 202080062919A CN 114340657 A CN114340657 A CN 114340657A
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seq
crispr
nucleic acid
associated protein
set forth
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Chinese (zh)
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D·A·斯科特
D·R·程
W·X·严
T·M·迪托马索
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Abbott Biotechnology
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Abbott Biotechnology
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CN202080062919.7A 2019-09-09 2020-09-09 新型crispr dna靶向酶及系统 Pending CN114340657A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962897859P 2019-09-09 2019-09-09
US62/897,859 2019-09-09
PCT/US2020/049923 WO2021050534A1 (en) 2019-09-09 2020-09-09 Novel crispr dna targeting enzymes and systems

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CN114340657A true CN114340657A (zh) 2022-04-12

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US (5) US12460190B2 (https=)
EP (1) EP4028047A4 (https=)
JP (2) JP7705382B2 (https=)
KR (1) KR20220054434A (https=)
CN (1) CN114340657A (https=)
AU (1) AU2020347147A1 (https=)
CA (1) CA3150454A1 (https=)
IL (1) IL291095A (https=)
MX (1) MX2022002872A (https=)
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ZA (1) ZA202202628B (https=)

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CN118813585A (zh) * 2022-12-06 2024-10-22 山东舜丰生物科技有限公司 Crispr酶和系统及应用

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AU2020347147A1 (en) 2019-09-09 2022-03-03 Arbor Biotechnologies, Inc. Novel CRISPR DNA targeting enzymes and systems
EP4081533A4 (en) * 2019-12-23 2024-03-20 The Regents of The University of California CRISPR-CAS EFFECTOR POLYPEPTIDES AND METHOD OF USE THEREOF
WO2022192381A1 (en) 2021-03-09 2022-09-15 Arbor Biotechnologies, Inc. Compositions comprising a variant polypeptide and uses thereof
US20240174997A1 (en) * 2021-03-09 2024-05-30 Arbor Biotechnologies, Inc. Compositions comprising a variant polypeptide and uses thereof
IL308806A (en) 2021-06-01 2024-01-01 Arbor Biotechnologies Inc Gene editing systems including nuclease crisper and their uses
WO2023250384A2 (en) * 2022-06-22 2023-12-28 The Regents Of The University Of California Crispr-cas effector polypeptides and methods of use thereof
WO2024020557A1 (en) * 2022-07-22 2024-01-25 Arbor Biotechnologies, Inc. Compositions comprising a variant nuclease and uses thereof
US20240035010A1 (en) * 2022-07-22 2024-02-01 Arbor Biotechnologies, Inc. Compositions comprising a variant polypeptide and uses thereof
WO2024173645A1 (en) 2023-02-15 2024-08-22 Arbor Biotechnologies, Inc. Gene editing method for inhibiting aberrant splicing in stathmin 2 (stmn2) transcript
WO2025006563A1 (en) 2023-06-26 2025-01-02 Arbor Biotechnologies, Inc. Gene editing systems targeting pcsk9 and uses thereof
WO2025171210A1 (en) 2024-02-09 2025-08-14 Arbor Biotechnologies, Inc. Compositions and methods for gene editing via homology-mediated end joining
WO2025212120A1 (en) 2024-04-05 2025-10-09 Arbor Biotechnologies, Inc. Chemical modifications of guide rnas for crispr nucleases
WO2026015829A2 (en) 2024-07-12 2026-01-15 Arbor Biotechnologies, Inc. Small reverse transcriptases and gene editing systems comprising such
WO2026015832A2 (en) 2024-07-12 2026-01-15 Arbor Biotechnologies, Inc. Reverse transcriptases and gene editing systems comprising such

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CN109153980A (zh) * 2015-10-22 2019-01-04 布罗德研究所有限公司 Vi-b型crispr酶和系统

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CN118813585A (zh) * 2022-12-06 2024-10-22 山东舜丰生物科技有限公司 Crispr酶和系统及应用
CN118813585B (zh) * 2022-12-06 2026-03-13 山东舜丰生物科技有限公司 Crispr酶和系统及应用

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US20230212542A1 (en) 2023-07-06
US20220033793A1 (en) 2022-02-03
US20240101990A1 (en) 2024-03-28
US12460190B2 (en) 2025-11-04
US20230057102A1 (en) 2023-02-23
KR20220054434A (ko) 2022-05-02
CA3150454A1 (en) 2021-03-18
US20220282308A1 (en) 2022-09-08
AU2020347147A1 (en) 2022-03-03
IL291095A (en) 2022-05-01
US11795442B2 (en) 2023-10-24
JP2022547524A (ja) 2022-11-14
JP7705382B2 (ja) 2025-07-09
JP2025161809A (ja) 2025-10-24
MX2022002872A (es) 2022-08-04
US11453867B2 (en) 2022-09-27
WO2021050534A1 (en) 2021-03-18
EP4028047A4 (en) 2023-07-26
EP4028047A1 (en) 2022-07-20
US11976308B2 (en) 2024-05-07

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