CA3150454A1 - Novel crispr dna targeting enzymes and systems - Google Patents

Novel crispr dna targeting enzymes and systems Download PDF

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Publication number
CA3150454A1
CA3150454A1 CA3150454A CA3150454A CA3150454A1 CA 3150454 A1 CA3150454 A1 CA 3150454A1 CA 3150454 A CA3150454 A CA 3150454A CA 3150454 A CA3150454 A CA 3150454A CA 3150454 A1 CA3150454 A1 CA 3150454A1
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Prior art keywords
seq
crispr
nucleic acid
previous
set forth
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CA3150454A
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English (en)
French (fr)
Inventor
David A. Scott
David R. Cheng
Winston X. YAN
Tia M. DITOMMASO
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Arbor Biotechnologies Inc
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Arbor Biotechnologies Inc
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/90—Stable introduction of foreign DNA into chromosome
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/20—Type of nucleic acid involving clustered regularly interspaced short palindromic repeats [CRISPR]
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    • C12N2800/00—Nucleic acids vectors
    • C12N2800/80—Vectors containing sites for inducing double-stranded breaks, e.g. meganuclease restriction sites

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  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
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  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
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  • Mycology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)
CA3150454A 2019-09-09 2020-09-09 Novel crispr dna targeting enzymes and systems Pending CA3150454A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962897859P 2019-09-09 2019-09-09
US62/897,859 2019-09-09
PCT/US2020/049923 WO2021050534A1 (en) 2019-09-09 2020-09-09 Novel crispr dna targeting enzymes and systems

Publications (1)

Publication Number Publication Date
CA3150454A1 true CA3150454A1 (en) 2021-03-18

Family

ID=74866391

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Application Number Title Priority Date Filing Date
CA3150454A Pending CA3150454A1 (en) 2019-09-09 2020-09-09 Novel crispr dna targeting enzymes and systems

Country Status (11)

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US (5) US12460190B2 (https=)
EP (1) EP4028047A4 (https=)
JP (2) JP7705382B2 (https=)
KR (1) KR20220054434A (https=)
CN (1) CN114340657A (https=)
AU (1) AU2020347147A1 (https=)
CA (1) CA3150454A1 (https=)
IL (1) IL291095A (https=)
MX (1) MX2022002872A (https=)
WO (1) WO2021050534A1 (https=)
ZA (1) ZA202202628B (https=)

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EP3204496A1 (en) 2014-10-10 2017-08-16 Editas Medicine, Inc. Compositions and methods for promoting homology directed repair
AU2020347147A1 (en) 2019-09-09 2022-03-03 Arbor Biotechnologies, Inc. Novel CRISPR DNA targeting enzymes and systems
EP4081533A4 (en) * 2019-12-23 2024-03-20 The Regents of The University of California CRISPR-CAS EFFECTOR POLYPEPTIDES AND METHOD OF USE THEREOF
WO2022192381A1 (en) 2021-03-09 2022-09-15 Arbor Biotechnologies, Inc. Compositions comprising a variant polypeptide and uses thereof
US20240174997A1 (en) * 2021-03-09 2024-05-30 Arbor Biotechnologies, Inc. Compositions comprising a variant polypeptide and uses thereof
IL308806A (en) 2021-06-01 2024-01-01 Arbor Biotechnologies Inc Gene editing systems including nuclease crisper and their uses
WO2023250384A2 (en) * 2022-06-22 2023-12-28 The Regents Of The University Of California Crispr-cas effector polypeptides and methods of use thereof
WO2024020557A1 (en) * 2022-07-22 2024-01-25 Arbor Biotechnologies, Inc. Compositions comprising a variant nuclease and uses thereof
US20240035010A1 (en) * 2022-07-22 2024-02-01 Arbor Biotechnologies, Inc. Compositions comprising a variant polypeptide and uses thereof
CN117625578B (zh) * 2022-12-06 2024-12-27 山东舜丰生物科技有限公司 Crispr酶和系统及应用
WO2024173645A1 (en) 2023-02-15 2024-08-22 Arbor Biotechnologies, Inc. Gene editing method for inhibiting aberrant splicing in stathmin 2 (stmn2) transcript
WO2025006563A1 (en) 2023-06-26 2025-01-02 Arbor Biotechnologies, Inc. Gene editing systems targeting pcsk9 and uses thereof
WO2025171210A1 (en) 2024-02-09 2025-08-14 Arbor Biotechnologies, Inc. Compositions and methods for gene editing via homology-mediated end joining
WO2025212120A1 (en) 2024-04-05 2025-10-09 Arbor Biotechnologies, Inc. Chemical modifications of guide rnas for crispr nucleases
WO2026015829A2 (en) 2024-07-12 2026-01-15 Arbor Biotechnologies, Inc. Small reverse transcriptases and gene editing systems comprising such
WO2026015832A2 (en) 2024-07-12 2026-01-15 Arbor Biotechnologies, Inc. Reverse transcriptases and gene editing systems comprising such

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WO2016094872A1 (en) 2014-12-12 2016-06-16 The Broad Institute Inc. Dead guides for crispr transcription factors
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Publication number Publication date
ZA202202628B (en) 2023-12-20
US20230212542A1 (en) 2023-07-06
US20220033793A1 (en) 2022-02-03
US20240101990A1 (en) 2024-03-28
US12460190B2 (en) 2025-11-04
US20230057102A1 (en) 2023-02-23
KR20220054434A (ko) 2022-05-02
US20220282308A1 (en) 2022-09-08
AU2020347147A1 (en) 2022-03-03
IL291095A (en) 2022-05-01
US11795442B2 (en) 2023-10-24
JP2022547524A (ja) 2022-11-14
JP7705382B2 (ja) 2025-07-09
CN114340657A (zh) 2022-04-12
JP2025161809A (ja) 2025-10-24
MX2022002872A (es) 2022-08-04
US11453867B2 (en) 2022-09-27
WO2021050534A1 (en) 2021-03-18
EP4028047A4 (en) 2023-07-26
EP4028047A1 (en) 2022-07-20
US11976308B2 (en) 2024-05-07

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