CN114317480B - Glycosyl transferase for catalytically synthesizing salidroside, and coding gene and application thereof - Google Patents
Glycosyl transferase for catalytically synthesizing salidroside, and coding gene and application thereof Download PDFInfo
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- CN114317480B CN114317480B CN202210023456.4A CN202210023456A CN114317480B CN 114317480 B CN114317480 B CN 114317480B CN 202210023456 A CN202210023456 A CN 202210023456A CN 114317480 B CN114317480 B CN 114317480B
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- China
- Prior art keywords
- leu
- hydroxytyrosol
- glu
- salidroside
- ser
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- 102000051366 Glycosyltransferases Human genes 0.000 title claims abstract description 32
- 108700023372 Glycosyltransferases Proteins 0.000 title claims abstract description 32
- 108090000623 proteins and genes Proteins 0.000 title claims abstract description 31
- ILRCGYURZSFMEG-UHFFFAOYSA-N Salidroside Natural products OC1C(O)C(O)C(CO)OC1OCCC1=CC=C(O)C=C1 ILRCGYURZSFMEG-UHFFFAOYSA-N 0.000 title claims abstract description 25
- ILRCGYURZSFMEG-RQICVUQASA-N salidroside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)OC1OCCC1=CC=C(O)C=C1 ILRCGYURZSFMEG-RQICVUQASA-N 0.000 title claims abstract description 11
- 230000002194 synthesizing effect Effects 0.000 title claims abstract description 8
- JUUBCHWRXWPFFH-UHFFFAOYSA-N Hydroxytyrosol Chemical compound OCCC1=CC=C(O)C(O)=C1 JUUBCHWRXWPFFH-UHFFFAOYSA-N 0.000 claims abstract description 59
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- 238000006243 chemical reaction Methods 0.000 claims abstract description 16
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Images
Landscapes
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
Components | Dosage (mu L) |
10×PCR Buffer for KOD-Plus-Neo | 5 |
2mMdNTPs | 5 |
|
3 |
Primer (F end) | 1.5 |
Primer (R end) | 1.5 |
|
1 |
distilled water | 29 |
KOD-Plus- |
1 |
|
50 |
Claims (9)
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CN118222658B (en) * | 2024-05-22 | 2024-07-26 | 天津凯莱英生物科技有限公司 | Method for biosynthesis of salidroside |
CN118207179B (en) * | 2024-05-22 | 2024-07-26 | 天津凯莱英生物科技有限公司 | Glycosyltransferase mutant and application thereof |
CN118389391A (en) * | 2024-06-21 | 2024-07-26 | 凯莱英医药集团(天津)股份有限公司 | Genetically engineered bacterium, preparation method thereof and application thereof in de novo synthesis of salidroside |
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US11408009B2 (en) * | 2017-12-18 | 2022-08-09 | Whitehead Institute For Biomedical Research | Host cell expression of 4-hydroxyphenylacetaldehyde synthase for production of salidroside, icariside D2, and precursors |
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