CN114306168A - Cosmetic composition for improving pores and preparation method thereof - Google Patents
Cosmetic composition for improving pores and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a cosmetic composition for improving pores and a preparation method thereof, wherein the cosmetic composition comprises the following raw materials: comprises a linseed-celery seed extract, wherein the content of cyclopeptide of the linseed is more than 40 percent, and the content of senkyunolide compounds of the celery seed is more than 35 percent; the preparation method comprises the following steps: (1) pulverizing semen Lini and Apii semen; (2) mixing semen Lini powder and Apii Graveolentis seed powder, and performing supercritical extraction to obtain crude extract composition; (3) decolorizing the crude extract composition to obtain decolorized composition; (4) purifying and decolorizing the decolorized composition by molecular distillation to obtain the cosmetic composition. The cosmetic composition has the characteristics of obvious pore reducing effect and high safety.
Description
Technical Field
The invention relates to a cosmetic composition, in particular to a cosmetic composition for improving pores and a preparation method thereof.
Background
The large skin pores are characterized by uneven skin surface depressions, which hinder the realization of healthy and delicate skin appearance, and the problem is widely concerned and urgently needed to be solved by the public. The reason for the large size of facial skin pores is that the pores increase in volume and appear under a focused laser microscope as the epidermis of the pores grows and extends into the dermis, and the papillary layer of the dermis rises to the level of the epidermis, forming an under-the-mirror "stalactite-like appearance". This causes uneven texture and a dimpled appearance of the skin to be seen by the naked eye. The inducing factors for pore enlargement include exogenous and endogenous factors, such as sex, genetic susceptibility, aging, chronic ultraviolet exposure, exogenous irritant substances, acne, seborrheic dermatitis, etc. Among them, age is closely related to the size of facial pores.
With the increase of age, the structure, cells and molecules of the skin are changed, so that not only the mechanical properties of the skin but also the biological and physiological functions of the skin are changed. Structurally, the epidermis becomes thinner, the dermal-epidermal junction relaxes, and the extracellular matrix components of the dermis are disturbed and degraded. The dermis is composed of two parts: the deepest and thickest part of the skin is reticular dermis; the papillary dermis of the cortex, which is thin and in close contact with the epidermis, plays an important role in the structure and function of the skin. Recent studies have shown that the dermal papilla is preferentially affected by skin aging, since the activity of fibroblasts in this area changes with age, the collagen fibers of the skin decrease, disorganization of the elastic fibers leads to a decrease in the elasticity of the skin, a decrease in the integrity of the skin, a relaxation of the supporting structure around the hair follicle, resulting in a change in the appearance of enlarged pores.
Currently, pores are reduced by medical cosmetic techniques, such as intense pulse light (photon skin tendering), laser, micro-needle and chemical exfoliation, but the treatment cost is high, and certain medical risks and side effects exist. However, most of the currently marketed pore-reducing cosmetics mainly control oil and brush acid, and are only targeted products applied to pore relaxation, and the cosmetics play a role in brushing acid, most commonly, the cosmetics are fruit acid and salicylic acid, and the components have certain irritation, and in terms of the allowable use concentration of the cosmetics, the content of the functional components is low, the pore-reducing effect is very limited, and the effect is not obvious.
Disclosure of Invention
The invention aims to provide a cosmetic composition for improving pores and a preparation method thereof. The composition has the characteristics of obvious effect of reducing pores and high safety.
The technical scheme of the invention is as follows: a cosmetic composition for improving pores comprises semen Lini-Apii seed extract, wherein the content of cyclic peptide of semen Lini is more than 0.05%, and the content of senkyunolide of Apii seed is more than 0.1%.
The preparation method of the cosmetic composition for improving pores comprises the following steps:
(1) crushing: pulverizing semen Lini, oven drying, sieving to remove semen Lini shell to obtain semen Lini powder; pulverizing and sieving Apium seeds to obtain Apium powder;
(2) extraction: respectively taking the linseed powder and the celery seed powder according to the mass ratio of 1: 2-3, adding absolute ethyl alcohol as an entrainer, and performing supercritical extraction by using supercritical extraction equipment at a material-liquid ratio (mass-volume ratio of material to entrainer) of 1: 0.5-0.9, wherein the extraction temperature is 25-40 ℃, the extraction time is 70-90min, and the extraction pressure is 15-25MPa to obtain a crude extraction composition;
(3) and (3) decoloring: adding activated clay 3-6% of the crude extract, stirring at 65 deg.C for decolorizing for 15min, and filtering to obtain decolorized composition.
(4) Purification and deodorization: the decolorization composition is purified and decolorized by molecular distillation under the conditions that the distillation pressure is 0.1Pa, the feeding temperature is 55-65 ℃, the feeding speed is 2-2.5L/min and the rotating speed of a wiped film is 200-300r/min, thus obtaining the cosmetic composition.
In the foregoing preparation method, in the step (1), the drying of the flaxseeds is specifically drying in an oven at 55 ℃ for 12 hours.
In the preparation method, the extraction temperature in the step (2) is 30 ℃, the extraction time is 80min, and the extraction pressure is 20 MPa.
In the foregoing production process, in the step (3), H2O2The amount of (B) added is 4%.
In the preparation method, in the step (3), the reaction temperature for decoloring is 56 ℃, and the reaction time is 42 min.
In the preparation method, in the step (4), the system pressure for molecular distillation purification and decolorization is 0.1Pa, the feeding temperature is 60 ℃, the feeding rate is 2.2L/min, and the rotating speed of the knifing is 250 r/min.
A cosmetic for improving pores contains the cosmetic composition, and the addition amount of the cosmetic composition is 1% -5%.
The linseed cyclopeptide is a characteristic lipid concomitant in linseed and linseed oil, and is not found in other higher plants at present and consists of 8 to 9 amino acids. Flaxseed contains more than ten kinds of cyclic peptides, and the total content is about 0.1%. The linseed cyclopeptide has the ability to stimulate or restore papillary fibroblast activity in young and old skin donors and can inhibit the release of MMP-1, thereby inhibiting the production of layered proteins and increasing the synthesis of collagen and elastin. The senkyunolide compounds in the seeds of the celery have various pharmacological actions such as oxidation damage resistance, anti-inflammatory and analgesic effects, anticoagulation and platelet aggregation resistance, vasodilatation and the like; can enhance mitochondrial activity, enhance skin barrier function, promote release of regnase-1mRNA, reduce release of inflammatory factors such as IL-8, IL-6, PGE2, control inflammatory reaction, and prevent skin aging.
Compared with the prior art, the linseed-celery seed extract is adopted to coexist linseed cyclopeptide and senkyunolide compounds, so that the epidermal layer structure and the dermal layer structure can be improved, the epidermal barrier can be strengthened, the structures of collagen and elastin around pores can be strengthened, the inflammation can be slowed down, the dermal matrix can be protected, the cell metabolism can be promoted, the problem of pore relaxation related to age aging can be effectively solved, and the skin aging can be delayed. The composition is colorless, odorless, stable in state, clear in action mechanism, and high in safety, and has obvious effect of improving follicular orifice. The extraction method is simple and can be used for industrial production. Moreover, the senkyunolide compounds in the celery seeds have a certain protection effect on the oxidation of cyclopeptide, so that the long-term stability of the linseed-celery seed extract is improved.
The preparation method can extract the linseed-celery seed extract at one time, the production process is simple to operate, and the obtained linseed-celery seed extract has a good pore improving effect. The whole extraction process is carried out at low temperature without high-temperature heating operation, so that the influence of the heating process on the stability of the linseed cyclopeptide is avoided, the methionine group of the cyclopeptide is prevented from being oxidized, and the stability of the linseed cyclopeptide in the linseed-celery seed extract is ensured.
Detailed Description
The present invention is further illustrated by the following examples, which are not to be construed as limiting the invention. The experimental procedures in the following examples are conventional unless otherwise specified. Materials, reagents, instruments and the like used in the following examples are commercially available unless otherwise specified.
Example 1:
a cosmetic composition for improving pores comprises semen Lini-Apii seed extract, wherein the content of cyclic peptide of semen Lini is more than 0.05%, and the content of senkyunolide of Apii seed is more than 0.1%.
The preparation method of the cosmetic composition comprises the following steps:
(1) crushing: pulverizing semen Lini, oven drying, sieving to remove semen Lini shell to obtain semen Lini powder; pulverizing and sieving Apium seeds to obtain Apium powder;
(2) extraction: respectively taking the linseed powder and the celery seed powder according to the mass ratio of 1: 2-3, adding absolute ethyl alcohol as an entrainer, and performing supercritical extraction by using supercritical extraction equipment at a material-liquid ratio (mass-volume ratio of material to entrainer) of 1: 0.5-0.9, wherein the extraction temperature is 25-40 ℃, the extraction time is 70-90min, and the extraction pressure is 15-25MPa to obtain a crude extraction composition;
(3) and (3) decoloring: adding activated clay 3-6% of the crude extract into the crude extract composition, stirring at 65 deg.C for decolorizing for 15min, and filtering to obtain decolorized composition;
(4) purification and deodorization: the decolorization composition is purified and decolorized by molecular distillation under the conditions that the system pressure is 0.1Pa, the feeding temperature is 55-65 ℃, the feeding speed is 2-2.5L/min and the rotating speed of a film scraper is 300r/min, thus obtaining the cosmetic composition.
A cosmetic for improving pores contains the above cosmetic composition, and the addition amount of the cosmetic composition is 1% -5%. The cosmetics comprise cream, lotion, essence and the like.
Example 2:
a method of preparing a cosmetic composition comprising the steps of:
(1) crushing: crushing flaxseeds, putting the crushed flaxseeds in a 55 ℃ oven for drying for 12 hours, and sieving the flaxseeds by a 80-mesh sieve to remove flaxseed shells to obtain flaxseed powder; crushing celery seeds, and sieving the crushed celery seeds with a 60-mesh sieve to obtain celery seed powder;
(2) extraction: respectively taking the linseed powder and the celery seed powder according to the mass ratio of 1: 2, mixing, adding absolute ethyl alcohol, and performing supercritical extraction by using supercritical extraction equipment at a material-liquid ratio of 1: 0.6, wherein the extraction temperature is 30 ℃, the extraction time is 80min, and the extraction pressure is 20MPa to obtain a crude extraction composition;
(3) and (3) decoloring: adding activated clay 4% of the crude extract, stirring at 65 deg.C for decolorizing for 15min, and filtering to obtain decolorized composition;
(4) purification and deodorization: and (3) carrying out molecular distillation purification and decoloration on the decoloration composition under the conditions that the system pressure is 0.1Pa, the feeding temperature is 60 ℃, the feeding rate is 2.2L/min and the rotating speed of a film scraper is 250r/min to obtain the cosmetic composition.
The obtained cosmetic composition is linseed-celery seed extract, wherein the content of cyclic peptide of linseed is more than 0.05%, and the content of senkyunolide compound of celery seed is more than 0.1%.
Performance testing of cosmetic compositions:
the finished cosmetic composition of example 2 was taken as a test sample;
taking a rhodiola rosea extract as a comparison sample;
skin barrier injury and repair experiments:
test subjects: 4 healthy nude mice (male) with the size of 8-10 weeks and the numbers of 1-4 respectively;
the test method comprises the following steps: selecting 3cm multiplied by 3cm parts on the left and right sides of mice with the numbers of 1, 2 and 3, continuously sticking the parts by using an adhesive tape, quickly tearing the parts for a plurality of times until the skin has a small blood spot, smearing a test sample on the left part of 3 mice as a sample group, smearing a comparison sample on the right part as a positive control group, smearing once a day, and performing pathological section microscopic examination on the skin tissue of the experimental part of the mice after continuously smearing for four days. The left side of the mouse with the number 4 was used as a normal group without any treatment, and the right side was used as a blank control group, which was continuously taped and quickly torn off several times until the skin appeared to have a small blood spot, after which no treatment was performed. The test results were analyzed in comparison and are shown in Table 1.
Table 1 skin barrier damage and repair test results
From the above test results, it can be seen that: compared with the blank control group, the stratum corneum of the skin epidermis of the sample group is basically recovered, and the recovery performance is stronger than that of the positive control group.
The cream for improving pores comprises the following components in percentage by mass:
phase A: 4% of propylene glycol, 3% of glycerol, 3% of carbomer 9400.3%, 70.5% of polyacrylamide C13-14 isoparaffin & laureth, and 69.05% of water;
phase B: caprylic capric triglyceride 5%, glyceryl stearate and PEG-100 stearate 3%, monoglyceride 0.5%, isopropyl palmitate 5%, dimethicone (100cs) 3%, cetearyl alcohol 1.5%, shea butter 1%;
and C phase: aminomethyl propanol 0.15%;
phase D: the cosmetic composition of example 2%.
The preparation process of the cream comprises the following steps: heating the components of phase A to 80 deg.C (carbomer 940 pre-dispersed with glycerol and propylene glycol); heating the components in the phase B to 80 ℃; adding phase B while stirring phase A, and homogenizing for 5 min; adding the C phase component while stirring; stirring, cooling, and taking half of the product as cream 1 after the product is cooled to 45 ℃; adding phase D into the other half, and homogenizing for 2 min; stirring and cooling the mixture continuously, and cooling the mixture to room temperature to obtain the cream 2.
The 2 creams are subjected to human body experiments, 30 female healthy subjects with age-related skin pores on the face of 35-50 years old are selected respectively, and the same amount of the creams are applied for 1 time and 8 weeks after the face is cleaned in the morning and evening each day. The indices of the skin of the subjects using VISIA and german CK instrument probes were tested once each after 1, 4, and 8 weeks before and after use.
After 4 weeks of application of the cream, the skin pores on the face were improved (p <0.05) compared to those before application, and after 8 weeks of application, the diameter of the skin pores was significantly improved (p <0.01), and the results are shown in table 2.
TABLE 2 improvement of skin after cream 1
TABLE 3 improvement of skin after cream 2
Therefore, by using the cream containing the cosmetic composition with the mass percentage of 2%, pores can be effectively reduced after 4 weeks, the elasticity and the firmness of the skin can be increased, the skin can be moistened, wrinkles can be reduced, and the skin color can be brightened. And has no allergy and high safety.
Claims (8)
1. A cosmetic composition for improving pores, characterized by: comprises linseed-celery seed extract, wherein the content of cyclopeptide of linseed is more than 0.05%, and the content of senkyunolide of celery seed is more than 0.1%.
2. The method for preparing a cosmetic composition for improving pores according to claim 1, wherein: the method comprises the following steps:
(1) crushing: pulverizing semen Lini, oven drying, sieving to remove semen Lini shell to obtain semen Lini powder; pulverizing and sieving Apium seeds to obtain Apium powder;
(2) extraction: respectively taking the linseed powder and the celery seed powder according to the mass ratio of 1: 2-3, adding absolute ethyl alcohol, and performing supercritical extraction at a material-liquid ratio of 1: 0.5-0.9 at 25-40 deg.C for 70-90min under 15-25MPa to obtain crude extract composition;
(3) and (3) decoloring: adding activated clay 3-6 wt% of the crude extract composition into the crude extract composition, decolorizing at 65 deg.C for 15-25min, and filtering to obtain decolorized composition;
(4) purification and deodorization: the decolorization composition is purified and decolorized by molecular distillation under the conditions that the distillation pressure is 0.1Pa, the feeding temperature is 55-65 ℃, the feeding speed is 2-2.5L/min and the rotating speed of a wiped film is 200-300r/min, thus obtaining the cosmetic composition.
3. A method of manufacturing according to claim 2, wherein: in the step (1), the drying of the flaxseeds is specifically drying in an oven at 55 ℃ for 12 hours.
4. A method of manufacturing according to claim 2, wherein: the extraction temperature in the step (2) is 30 ℃, the extraction time is 80min, and the extraction pressure is 20 MPa.
5. A method of manufacturing according to claim 2, wherein: in the step (3), H2O2The amount of (B) added is 4%.
6. A method of manufacturing according to claim 2, wherein: in the step (3), the reaction temperature for decoloring is 56 ℃, and the reaction time is 42 min.
7. A method of manufacturing according to claim 2, wherein: in the step (4), the system pressure for molecular distillation purification and decoloration is 0.1Pa, the feeding temperature is 60 ℃, the feeding rate is 2.2L/min, and the rotating speed of a film scraper is 250 r/min.
8. A cosmetic for improving pores, which is characterized in that: the cosmetic composition according to claim 1, wherein the amount of the cosmetic composition added is 1% to 5%.
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| CN202210060108.4A CN114306168A (en) | 2022-01-19 | 2022-01-19 | Cosmetic composition for improving pores and preparation method thereof |
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| JP2009242311A (en) * | 2008-03-31 | 2009-10-22 | Kose Corp | Scf secretion inhibitor and skin care preparation for external use for making skin pore inconspicuous |
| CN110882186A (en) * | 2019-12-25 | 2020-03-17 | 珠海姗拉娜化妆品有限公司 | Composition with effects of controlling oil, shrinking pores and relieving and preparation method thereof |
| CN111670027A (en) * | 2018-02-01 | 2020-09-15 | 赛德玛公司 | Use of cyclic peptides in cosmetics |
| US20210093537A1 (en) * | 2018-04-05 | 2021-04-01 | Sederma | Use of a peptide for the treatment of epiderm |
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2022
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009242311A (en) * | 2008-03-31 | 2009-10-22 | Kose Corp | Scf secretion inhibitor and skin care preparation for external use for making skin pore inconspicuous |
| CN111670027A (en) * | 2018-02-01 | 2020-09-15 | 赛德玛公司 | Use of cyclic peptides in cosmetics |
| US20210093537A1 (en) * | 2018-04-05 | 2021-04-01 | Sederma | Use of a peptide for the treatment of epiderm |
| CN110882186A (en) * | 2019-12-25 | 2020-03-17 | 珠海姗拉娜化妆品有限公司 | Composition with effects of controlling oil, shrinking pores and relieving and preparation method thereof |
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