CN114305659B - High-frequency bipolar unrecoverable electroporation system - Google Patents
High-frequency bipolar unrecoverable electroporation system Download PDFInfo
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- CN114305659B CN114305659B CN202111607045.1A CN202111607045A CN114305659B CN 114305659 B CN114305659 B CN 114305659B CN 202111607045 A CN202111607045 A CN 202111607045A CN 114305659 B CN114305659 B CN 114305659B
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Abstract
The invention provides a high-frequency bipolar unrecoverable electroporation system, which comprises a bipolar electroporation module, a data acquisition module and a perforation adjustment module; the bipolar perforation module comprises a bipolar pulse generator and a pulse control unit, the pulse control unit is respectively connected with the perforation adjusting module and the bipolar pulse generator, and the pulse control unit is used for receiving an adjusting instruction of the perforation adjusting module and controlling the operation of the bipolar pulse generator according to the adjusting instruction; the data acquisition module comprises a cell characteristic pre-acquisition unit, a pulse parameter acquisition unit and a cell therapy parameter acquisition unit; the cell characteristic pre-acquisition unit is used for acquiring cell basic characteristics before treatment, and pulse output parameters can be transformed based on the basic characteristics of different cell levels and treatment effects so as to solve the problem of poor high-frequency perforation treatment effect in the prior art.
Description
Technical Field
The invention relates to the technical field of pulse perforation treatment, in particular to a high-frequency bipolar unrecoverable electroporation system.
Background
The high-frequency bipolar pulse in the high-frequency bipolar unrecoverable electroporation system outputs bipolar pulses by using the control module, and output parameters of the bipolar pulses can be adjusted by using the control module, wherein the pulses generally refer to electric shock which is applied frequently in the electronic technology and has transient fluctuation like pulses, and the application of pulsed electric fields in the existing medical field is more and more extensive, especially the application of ablation and perforation on cells is more and more extensive.
In the prior art, in the application of high-frequency pulse perforation therapy, therapy is usually performed based on specific preset perforation parameters, because cells have different levels, and requirements of each level on the perforation parameters are different, it is difficult to perform targeted therapy according to the basic characteristics of the cells in the prior art, and the perforation process cannot be accurately judged, so that the perforation therapy effect is weak, and the therapy effect is poor.
Disclosure of Invention
Aiming at the defects in the prior art, the invention aims to provide a high-frequency bipolar unrecoverable electroporation system which can transform pulse output parameters based on the basic characteristics of different cell levels and the treatment effect so as to solve the problem of poor high-frequency electroporation treatment effect in the prior art.
In order to achieve the purpose, the invention is realized by the following technical scheme: the high-frequency bipolar unrecoverable electroporation system comprises a bipolar electroporation module, a data acquisition module and a perforation adjustment module;
the bipolar perforation module comprises a bipolar pulse generator and a pulse control unit, the pulse control unit is respectively connected with the perforation adjusting module and the bipolar pulse generator, and the pulse control unit is used for receiving an adjusting instruction of the perforation adjusting module and controlling the operation of the bipolar pulse generator according to the adjusting instruction;
the data acquisition module comprises a cell characteristic pre-acquisition unit, a pulse parameter acquisition unit and a cell therapy parameter acquisition unit; the cell characteristic pre-acquisition unit is used for acquiring cell basic characteristics before treatment, the pulse parameter acquisition unit is used for acquiring output parameters of a pulse generator in the treatment process, and the cell treatment parameter acquisition unit is used for acquiring cell treatment characteristics in the treatment process;
the perforation adjusting module comprises a cell characteristic preprocessing unit, a cell change processing unit and an adjusting unit, wherein the cell characteristic preprocessing unit is respectively connected with the pulse control unit and the cell characteristic pre-collecting unit and is used for processing cell basic characteristics to obtain pulse basic parameters and outputting the obtained pulse basic parameters to the pulse control unit;
the cell change processing unit is connected with the cell characteristic pre-acquisition unit and the cell treatment parameter acquisition unit and is used for processing the acquired cell basic characteristics and cell treatment characteristics and obtaining a cell change result;
the adjusting unit is connected with the cell change processing unit and the pulse parameter acquiring unit, and is used for processing the cell change result and the output parameter of the pulse generator to obtain an adjusting result, converting the adjusting result into an adjusting instruction and outputting the adjusting instruction to the pulse control unit.
Further, the basic characteristics of the cells collected by the cell characteristic pre-collecting unit comprise cell membrane thickness, cytoplasm thickness, cell nucleus membrane thickness and cell nucleus cytoplasm thickness;
the output parameters of the pulse generator collected by the pulse parameter acquisition unit comprise pulse width;
the cell therapy characteristics in the therapy process acquired by the cell therapy parameter acquisition unit comprise a cell membrane potential value, cell membrane conductivity and a perforation aperture.
Further, the cell characteristic preprocessing unit is configured with a cell characteristic preprocessing strategy, which comprises: substituting the cell membrane thickness, the cytoplasm thickness, the cell nucleus membrane thickness and the cell nucleus cytoplasm thickness into a pulse basic formula to obtain a pulse basic parameter value;
and outputting the pulse basic parameter value to a pulse control unit.
Further, the pulse basis formula is configured to:
Mjc＝(k1×Hxm×2+k2×Hxz×2+k3×Hxhm×2+k4×Hxhz) α (ii) a Wherein Mjc is a pulse basic parameter value, Hxm is a cell membrane thickness, Hxz is a cytoplasm thickness, Hxhm is a cell nucleus membrane thickness, Hxhz is a cell nucleus cytoplasm thickness, k1 is a cell membrane parameter proportion value, k2 is a cytoplasm parameter proportion value, k3 is a cell nucleus membrane parameter proportion value, k4 is a cell nucleus cytoplasm parameter proportion value, and alpha is a cell basic characteristic pulse conversion coefficient.
Further, the cell change processing unit is configured with a cell change processing strategy comprising: acquiring data acquired by the cell therapy parameter acquisition unit once every first change time;
introducing the obtained cell membrane potential value, cell membrane conductivity and perforation aperture of the first change times, and cell membrane thickness, cytoplasm thickness, cell nucleus membrane thickness and cell nucleus cytoplasm thickness into a cell change formula to obtain a cell change reference value;
the cell change reference value is output to the adjustment unit.
Further, the cellular variation formula is configured to:
wherein Cbh is a cell change reference value, i is a first change number, a Dxm1 value Dxmi is a cell membrane potential value obtained from the first time within the first change number to a cell membrane potential value obtained from the ith time, Dxm1 to Dxm is a cell membrane conductivity obtained from the first time within the first change number to a cell membrane conductivity obtained from the ith time, Jc1 to Jci are a perforation aperture obtained from the first time within the first change number to a perforation aperture obtained from the ith time, l1 is a reference ratio value of the cell membrane potential value, l2 is a reference ratio value of the cell membrane conductivity, and l3 is a reference ratio value of the perforation aperture.
Further, the adjusting unit is configured with an adjusting strategy, which includes: obtaining a pulse parameter adjustment value by substituting the pulse width, the pulse basic parameter value, the cell change reference value and a pulse adjustment formula;
and outputting the pulse parameter adjustment value to a pulse control unit.
Further, the pulse adjustment formula is configured to:
wherein, Mct is a pulse parameter adjustment value, Mk is a pulse width, beta is a pulse conversion ratio, and lambda is a cell change compensation coefficient.
The invention has the beneficial effects that:
1. the bipolar perforation module comprises a bipolar pulse generator and a pulse control unit, the pulse control unit can receive an adjusting instruction of the perforation adjusting module and control the operation of the bipolar pulse generator according to the adjusting instruction, and the design can adjust pulse output parameters in time according to the actual treatment process and improve the convenience of adjustment and control.
2. The data acquisition module comprises a cell characteristic pre-acquisition unit, a pulse parameter acquisition unit and a cell treatment parameter acquisition unit, wherein the cell characteristic pre-acquisition unit can acquire cell basic characteristics before treatment, the pulse parameter acquisition unit can acquire output parameters of a pulse generator in the treatment process, and the cell treatment parameter acquisition unit can acquire cell treatment characteristics in the treatment process.
3. The perforation adjusting module comprises a cell characteristic preprocessing unit, a cell change processing unit and an adjusting unit, wherein the cell characteristic preprocessing unit is used for processing cell basic characteristics to obtain pulse basic parameters and outputting the obtained pulse basic parameters to a pulse control unit; the cell change processing unit can process the acquired cell basic characteristics and cell treatment characteristics to obtain a cell change result; the adjustment unit can process the cell change result and the output parameters of the pulse generator to obtain an adjustment result, and the adjustment result is converted into an adjustment instruction to be output to the pulse control unit.
Drawings
Other features, objects and advantages of the invention will become more apparent upon reading of the detailed description of non-limiting embodiments with reference to the following drawings:
FIG. 1 is a functional block diagram of the present invention;
fig. 2 is a schematic block diagram illustrating the connection of the bipolar perforation module, the data acquisition module, and the perforation adjustment module according to the present invention.
Detailed Description
In order to make the technical means, the creation characteristics, the achievement purposes and the effects of the invention easy to understand, the invention is further described with the specific embodiments.
Referring to fig. 1, the high-frequency bipolar non-recoverable electroporation system includes a bipolar electroporation module, a data acquisition module, and a perforation adjustment module.
Referring to fig. 2, the bipolar perforation module includes a bipolar pulse generator and a pulse control unit, the pulse control unit is respectively connected to the perforation adjustment module and the bipolar pulse generator, and the pulse control unit is configured to receive an adjustment instruction from the perforation adjustment module and control the operation of the bipolar pulse generator according to the adjustment instruction. The output parameters of the bipolar pulse generator can be adjusted in time by arranging the pulse control unit, so that the convenience of adjustment is improved, and the timeliness of adjustment in the treatment process is improved.
The data acquisition module comprises a cell characteristic pre-acquisition unit, a pulse parameter acquisition unit and a cell therapy parameter acquisition unit; the cell characteristic pre-acquisition unit is used for acquiring basic cell characteristics before treatment, the basic cell characteristics acquired by the cell characteristic pre-acquisition unit comprise cell membrane thickness, cytoplasm thickness, cell nucleus membrane thickness and cell nucleus cytoplasm thickness, wherein the cell membrane thickness multiplied by two + cytoplasm thickness multiplied by two + cell nucleus membrane thickness multiplied by two + cell nucleus cytoplasm thickness equals to the diameter of a cell, and the acquired parameters can be compared with the perforation aperture acquired in the subsequent treatment process for reference.
The pulse parameter acquisition unit is used for acquiring output parameters of the pulse generator in the treatment process, and the output parameters of the pulse generator acquired by the pulse parameter acquisition unit comprise pulse width which influences the perforation effect.
The cell therapy parameter acquisition unit is used for acquiring cell therapy characteristics in a therapy process; the cell therapy characteristics in the therapy process acquired by the cell therapy parameter acquisition unit comprise a cell membrane potential value, cell membrane conductivity and a perforation aperture, and the cell perforation efficiency can be reflected by the cell membrane potential value, the cell membrane conductivity and the perforation aperture.
The perforation adjusting module comprises a cell characteristic preprocessing unit, a cell change processing unit and an adjusting unit, wherein the cell characteristic preprocessing unit is respectively connected with the pulse control unit and the cell characteristic pre-collecting unit and is used for processing cell basic characteristics to obtain pulse basic parameters and outputting the obtained pulse basic parameters to the pulse control unit; the cell characteristic preprocessing unit is configured with a cell characteristic preprocessing strategy, and the cell characteristic preprocessing strategy comprises the following steps: substituting the cell membrane thickness, the cytoplasm thickness, the cell nucleus membrane thickness and the cell nucleus cytoplasm thickness into a pulse basic formula to obtain a pulse basic parameter value; and outputting the pulse basic parameter value to a pulse control unit.
The pulse basis formula is configured to:
Mjc＝(k1×Hxm×2+k2×Hxz×2+k3×Hxhm×2+k4×Hxhz) α (ii) a Mjc is a pulse basic parameter value, Hxm is a cell membrane thickness, Hxz is a cell cytoplasm thickness, Hxhm is a cell nucleus membrane thickness, Hxhz is a cell nucleus cytoplasm thickness, k1 is a cell membrane parameter proportion value, k2 is a cell cytoplasm parameter proportion value, k3 is a cell nucleus membrane parameter proportion value, k4 is a cell nucleus cytoplasm parameter proportion value, and alpha is a cell basic characteristic pulse conversion coefficient, wherein k1, k2, k3, k4 and alpha are all larger than zero, the specific settings of k1, k2, k3 and k4 are preset according to the proportion of corresponding cell characteristics, and alpha can be used for presetting and adjusting the overall characteristics.
The cell change processing unit is connected with the cell characteristic pre-acquisition unit and the cell treatment parameter acquisition unit and is used for processing the acquired cell basic characteristics and cell treatment characteristics and obtaining a cell change result; the cell change processing unit is configured with a cell change processing strategy comprising: and acquiring the data acquired by the cell therapy parameter acquisition unit once every first change time.
Introducing the obtained cell membrane potential value, cell membrane conductivity and perforation aperture of the first change times, cell membrane thickness, cytoplasm thickness, cell nucleus membrane thickness and cell nucleus cytoplasm thickness into a cell change formula to obtain a cell change reference value; the cell change reference value is output to the adjustment unit. The first variation time is set according to a preset treatment period, and in particular, if the preset treatment period is set to 100 units, the first variation time can be set to 5, the first variation number is set to 4, within one treatment period, 5 first variable number of data acquisitions may be performed, and the 5 acquisitions may be respectively set as a first treatment cycle, a second treatment cycle, a third treatment cycle, a fourth treatment cycle, and a fifth treatment cycle, wherein the first treatment cycle and the second treatment cycle are anterior segment treatments, the third treatment cycle is a middle segment treatment, the fourth treatment cycle and the fifth treatment cycle are posterior segment treatments, the data acquisition is carried out on different treatment periods, the treatment effect of each treatment period can be reflected, on one hand, basic reference can be carried out on the treatment process, and on the other hand, the treatment data can be accumulated.
The cellular variation formula is configured to:
wherein Cbh is a cell change reference value, i is a first change time, Dxm1 value Dxmi is a cell membrane potential value obtained from the first time within the first change time to a cell membrane potential value obtained from the ith time, Ddxm1 to Ddxm are cell membrane conductivity obtained from the first time within the first change time to cell membrane conductivity obtained from the ith time, Jc1 to Jci are perforation aperture obtained from the first time within the first change time to perforation aperture obtained from the ith time, l1 is a reference ratio value of cell membrane potential values, l2 is a reference ratio value of cell membrane conductivity, and l3 is a reference ratio value of perforation aperture, wherein l1, l2 and l3 are all larger than zero, and the setting standard is set according to the cell membrane potential value, the cell membrane conductivity and the specific influence ratio of perforation aperture. In the above implementation where the treatment cycle is set to 100 units, i is set to 4.
The adjusting unit is connected with the cell change processing unit and the pulse parameter acquiring unit, and is used for processing the cell change result and the output parameter of the pulse generator to obtain an adjusting result, converting the adjusting result into an adjusting instruction and outputting the adjusting instruction to the pulse control unit.
The adjusting unit is configured with an adjusting strategy, which includes: obtaining a pulse parameter adjustment value by substituting the pulse width, the pulse basic parameter value, the cell change reference value and a pulse adjustment formula; and outputting the pulse parameter adjustment value to a pulse control unit.
The pulse adjustment formula is configured to:
mct is a pulse parameter adjustment value, Mk is a pulse width, beta is a pulse conversion ratio, and lambda is a cell change compensation coefficient, wherein beta and lambda are both larger than zero, beta is set according to preset standards of the pulse parameter and the pulse width, and can also be finely adjusted according to the actual treatment effect, and lambda is set according to the compensation of the amplitude of the cell change.
The working principle is as follows: in a specific treatment process, the pulse control unit can receive an adjusting instruction of the perforation adjusting module and control the operation of the bipolar pulse generator according to the adjusting instruction, the cell characteristic pre-collecting unit can collect cell basic characteristics before treatment, the pulse parameter acquiring unit can acquire output parameters of the pulse generator in the treatment process, and the cell treatment parameter acquiring unit can acquire cell treatment characteristics in the treatment process; then, the cell characteristic preprocessing unit is used for processing the cell basic characteristics to obtain pulse basic parameters, and the obtained pulse basic parameters are output to the pulse control unit; the cell change processing unit can process the acquired cell basic characteristics and cell treatment characteristics to obtain a cell change result; the cell change result and the output parameters of the pulse generator can be processed by the adjusting unit to obtain an adjusting result, the adjusting result is converted into an adjusting instruction to be output to the pulse control unit, and the bipolar pulse generator is controlled by the pulse control unit to operate again.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that the following descriptions are only illustrative and not restrictive, and that the scope of the present invention is not limited to the above embodiments: any person skilled in the art can modify or easily conceive the technical solutions described in the foregoing embodiments or equivalent substitutes for some technical features within the technical scope of the present disclosure; such modifications, changes or substitutions do not depart from the spirit and scope of the embodiments of the present invention, and they should be construed as being included therein. Therefore, the protection scope of the present invention shall be subject to the protection scope of the claims.
Claims (1)
1. The high-frequency bipolar unrecoverable electroporation system is characterized by comprising a bipolar perforation module, a data acquisition module and a perforation adjustment module;
the bipolar perforation module comprises a bipolar pulse generator and a pulse control unit, the pulse control unit is respectively connected with the perforation adjusting module and the bipolar pulse generator, and the pulse control unit is used for receiving an adjusting instruction of the perforation adjusting module and controlling the operation of the bipolar pulse generator according to the adjusting instruction;
the data acquisition module comprises a cell characteristic pre-acquisition unit, a pulse parameter acquisition unit and a cell therapy parameter acquisition unit; the cell characteristic pre-acquisition unit is used for acquiring cell basic characteristics before treatment, the pulse parameter acquisition unit is used for acquiring output parameters of a pulse generator in the treatment process, and the cell treatment parameter acquisition unit is used for acquiring cell treatment characteristics in the treatment process;
the perforation adjusting module comprises a cell characteristic preprocessing unit, a cell change processing unit and an adjusting unit, wherein the cell characteristic preprocessing unit is respectively connected with the pulse control unit and the cell characteristic pre-collecting unit and is used for processing cell basic characteristics to obtain pulse basic parameters and outputting the obtained pulse basic parameters to the pulse control unit;
the cell change processing unit is connected with the cell characteristic pre-acquisition unit and the cell treatment parameter acquisition unit and is used for processing the acquired cell basic characteristics and cell treatment characteristics and obtaining a cell change result;
the adjusting unit is connected with the cell change processing unit and the pulse parameter acquiring unit, and is used for processing the cell change result and the output parameter of the pulse generator to obtain an adjusting result, converting the adjusting result into an adjusting instruction and outputting the adjusting instruction to the pulse control unit;
the basic characteristics of the cells collected by the cell characteristic pre-collecting unit comprise cell membrane thickness, cytoplasm thickness, cell nucleus membrane thickness and cell nucleus cytoplasm thickness;
the output parameters of the pulse generator collected by the pulse parameter acquisition unit comprise pulse width;
the cell therapy characteristics in the therapy process acquired by the cell therapy parameter acquisition unit comprise a cell membrane potential value, cell membrane conductivity and a perforation aperture;
the cell characteristic preprocessing unit is configured with a cell characteristic preprocessing strategy, and the cell characteristic preprocessing strategy comprises the following steps: substituting the cell membrane thickness, the cytoplasm thickness, the cell nucleus membrane thickness and the cell nucleus cytoplasm thickness into a pulse basic formula to obtain a pulse basic parameter value;
outputting the pulse basic parameter value to a pulse control unit;
the pulse basis formula is configured to: mjc ═ k1 × Hxm × 2+ k2 × Hxz × 2+ k3 × Hxhm × 2+ k4 × Hxhz) α ；
Wherein Mjc is a pulse basic parameter value, Hxm is a cell membrane thickness, Hxz is a cytoplasm thickness, Hxhm is a cell nucleus membrane thickness, Hxhz is a cell nucleus cytoplasm thickness, k1 is a cell membrane parameter ratio value, k2 is a cytoplasm parameter ratio value, k3 is a cell nucleus membrane parameter ratio value, k4 is a cell nucleus cytoplasm parameter ratio value, and alpha is a cell basic characteristic pulse conversion coefficient;
the cell change processing unit is configured with a cell change processing strategy comprising: acquiring data acquired by the cell therapy parameter acquisition unit once every first change time;
introducing the obtained cell membrane potential value, cell membrane conductivity and perforation aperture of the first change times, and cell membrane thickness, cytoplasm thickness, cell nucleus membrane thickness and cell nucleus cytoplasm thickness into a cell change formula to obtain a cell change reference value;
outputting the cell change reference value to an adjusting unit;
the cellular change formula is configured to:
wherein Cbh is a cell change reference value, i is a first change number, a Dxm1 value Dxmi is a cell membrane potential value obtained from the first time within the first change number to a cell membrane potential value obtained from the ith time, Dxm1 to Dxm is a cell membrane conductivity obtained from the first time within the first change number to a cell membrane conductivity obtained from the ith time, Jc1 to Jci are a perforation aperture obtained from the first time within the first change number to a perforation aperture obtained from the ith time, l1 is a reference ratio value of the cell membrane potential value, l2 is a reference ratio value of the cell membrane conductivity, and l3 is a reference ratio value of the perforation aperture;
the adjusting unit is configured with an adjusting strategy, which includes: obtaining a pulse parameter adjustment value by substituting the pulse width, the pulse basic parameter value, the cell change reference value and a pulse adjustment formula;
outputting the pulse parameter adjustment value to a pulse control unit;
the pulse adjustment formula is configured to:
wherein, Mct is the pulse parameter adjustment value, Mk is the pulse width, beta is the pulse conversion ratio, and lambda is the cell change compensation coefficient.
The cell characteristic pre-acquisition unit can acquire cell basic characteristics before treatment, the pulse parameter acquisition unit can acquire output parameters of the pulse generator in the treatment process, and the cell treatment parameter acquisition unit can acquire cell treatment characteristics in the treatment process; then, the cell characteristic preprocessing unit is used for processing the cell basic characteristics to obtain pulse basic parameters, and the obtained pulse basic parameters are output to the pulse control unit; the cell change processing unit can process the acquired cell basic characteristics and cell treatment characteristics to obtain a cell change result; the cell change result and the output parameter of the pulse generator can be processed by the adjusting unit to obtain an adjusting result, the adjusting result is converted into an adjusting instruction to be output to the pulse control unit, and the bipolar pulse generator is controlled to operate by the pulse control unit again.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109661210A (en) * | 2016-07-12 | 2019-04-19 | 上海睿刀医疗科技有限公司 | Irreversible electroporation device and its operating method |
| CN215084247U (en) * | 2021-03-29 | 2021-12-10 | 中国信息通信研究院 | Electroporation control parameter acquisition device, electroporation control device and system |
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| US10238447B2 (en) * | 2008-04-29 | 2019-03-26 | Virginia Tech Intellectual Properties, Inc. | System and method for ablating a tissue site by electroporation with real-time monitoring of treatment progress |
| CN112807074A (en) * | 2014-05-12 | 2021-05-18 | 弗吉尼亚暨州立大学知识产权公司 | Electroporation system |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN109661210A (en) * | 2016-07-12 | 2019-04-19 | 上海睿刀医疗科技有限公司 | Irreversible electroporation device and its operating method |
| CN215084247U (en) * | 2021-03-29 | 2021-12-10 | 中国信息通信研究院 | Electroporation control parameter acquisition device, electroporation control device and system |
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