CN114305652A - Micropore electrode for blood vessel calcification breaking treatment - Google Patents
Micropore electrode for blood vessel calcification breaking treatment Download PDFInfo
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- CN114305652A CN114305652A CN202111500131.2A CN202111500131A CN114305652A CN 114305652 A CN114305652 A CN 114305652A CN 202111500131 A CN202111500131 A CN 202111500131A CN 114305652 A CN114305652 A CN 114305652A
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- conductive wire
- hole
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- balloon
- anode
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- 210000004204 blood vessel Anatomy 0.000 title description 10
- 230000002308 calcification Effects 0.000 title description 6
- 239000007788 liquid Substances 0.000 claims abstract description 31
- 208000005475 Vascular calcification Diseases 0.000 claims abstract description 29
- 229910052751 metal Inorganic materials 0.000 claims description 24
- 239000002184 metal Substances 0.000 claims description 24
- 239000011248 coating agent Substances 0.000 claims description 16
- 238000000576 coating method Methods 0.000 claims description 16
- 230000005611 electricity Effects 0.000 claims description 8
- 238000002844 melting Methods 0.000 claims description 5
- 230000008018 melting Effects 0.000 claims description 5
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 abstract description 5
- 238000007599 discharging Methods 0.000 abstract description 2
- 230000035939 shock Effects 0.000 description 10
- 239000007791 liquid phase Substances 0.000 description 9
- 208000004434 Calcinosis Diseases 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 230000003902 lesion Effects 0.000 description 5
- 238000005516 engineering process Methods 0.000 description 4
- 210000005077 saccule Anatomy 0.000 description 4
- 238000010586 diagram Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000002792 vascular Effects 0.000 description 2
- 206010003225 Arteriospasm coronary Diseases 0.000 description 1
- 206010003671 Atrioventricular Block Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 206010019280 Heart failures Diseases 0.000 description 1
- 208000007177 Left Ventricular Hypertrophy Diseases 0.000 description 1
- 208000007536 Thrombosis Diseases 0.000 description 1
- 230000036471 bradycardia Effects 0.000 description 1
- 208000006218 bradycardia Diseases 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 230000010102 embolization Effects 0.000 description 1
- 238000013467 fragmentation Methods 0.000 description 1
- 238000006062 fragmentation reaction Methods 0.000 description 1
- 208000031225 myocardial ischemia Diseases 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000000149 penetrating effect Effects 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 231100000216 vascular lesion Toxicity 0.000 description 1
- 230000024883 vasodilation Effects 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
- A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
Abstract
The invention belongs to the field of medical instruments, and relates to a microporous electrode for vascular calcification breaking treatment, which comprises a balloon, wherein a liquid medium is filled in the balloon; a catheter penetrates through the balloon, a cathode conductive wire and an anode conductive wire are arranged in the catheter, and an insulating layer is arranged on the outer surface of the anode conductive wire; a first through hole and a second through hole are arranged on the wall of the guide pipe, and the first through hole is a cathode discharge hole; the insulating layer is provided with a third through hole, and the second through hole is communicated with the third through hole to form an anode discharge hole together; the cathode conductive wire is communicated with the liquid medium in the balloon through a cathode discharge hole; the anode conductive wire is communicated with the liquid medium in the balloon through the anode discharge hole. The invention provides a microporous electrode for vascular calcification breaking treatment, which is convenient to manufacture, low in cost, longer in service life and capable of stably discharging.
Description
Technical Field
The invention belongs to the field of medical instruments, and relates to a microporous electrode for vascular calcification breaking treatment.
Background
Vascular calcification refers to a disease in which calcium is deposited on the vascular wall, which can cause the vascular wall to become hard and reduce compliance, and is also easy to cause diseases with high fatality rate and disability rate, such as myocardial ischemia, left ventricular hypertrophy, heart failure, thrombosis, plaque rupture, and the like. Vascular calcification is often carried through a variety of complex vascular lesions, and calcified lesions are often accompanied by angulated, distorted lesions of the blood vessel. Meanwhile, calcified lesions respond poorly to vasodilation.
The traditional methods for treating calcified lesions in blood vessels mainly comprise: non-compliant balloons, cutting balloons, scoring balloons, rotational atherectomy, excimer laser. These methods are generally applicable only to mild and moderate calcified lesions, but only to superficial calcifications and not to severe and deep calcifications. There is even a risk of complications that may arise from coronary dissection, coronary perforation, bradycardia and atrioventricular block, coronary spasm, slow/no reflow, distal embolization. It can be seen that there are still large pain spots in clinic for vascular calcification, and there are many unmet needs.
The liquid phase pulse discharge plasma technology is a technology for generating plasma by using high-voltage pulse discharge in water. Mechanical waves such as shock waves and acoustic waves are also generated along with the generation of the liquid phase pulse discharge plasma. The liquid phase discharge device is placed in a blood vessel, and the shock wave and the sound wave generated by liquid phase pulse discharge are utilized to break the calcified layer of the blood vessel, so that the effect of the traditional treatment method for calcified blood vessel can be realized, and the shock wave and the sound wave can reach the calcified region of the deep layer directly to break the calcified layer. Meanwhile, the liquid phase pulse discharge shock wave and the sound wave are in flexible contact with human tissues such as blood vessels, so that normal organ tissues cannot be damaged.
The electrode structure of the prior intravascular shock wave technology and device for endovascular calcification is complex, the manufacturing cost is high, and the manufacturing is difficult.
Disclosure of Invention
In order to overcome the problems in the prior art, the invention provides a microporous electrode for vascular calcification breaking treatment, which is convenient to manufacture, low in cost, longer in service life and capable of stably discharging.
The technical scheme for solving the problems is as follows: a micropore electrode for the treatment of vascular calcification fracture is characterized in that:
comprises a saccule, wherein a liquid medium is filled in the saccule; a catheter penetrates through the balloon, a cathode conductive wire and an anode conductive wire are arranged in the catheter, and an insulating layer is arranged on the outer surface of the anode conductive wire; a first through hole and a second through hole are arranged on the wall of the guide pipe, and the first through hole is a cathode discharge hole; the insulating layer is provided with a third through hole, and the second through hole is communicated with the third through hole to form an anode discharge hole together; the cathode conductive wire is communicated with the liquid medium in the balloon through a cathode discharge hole; the anode conductive wire is communicated with the liquid medium in the balloon through the anode discharge hole.
Preferably, the cathode conductive wire and the anode conductive wire are arranged in parallel in the conduit.
Preferably, the cathode discharge hole and the anode discharge hole are oppositely arranged.
Preferably, the cathode conductive wire and the anode conductive wire are both high-melting-point metal conductive wires.
Preferably, the cathode conductive wire and the anode conductive wire are connected with a pulse power supply, and the cathode conductive wire and the anode conductive wire are driven by the pulse power supply to discharge electricity in a liquid medium in the balloon to generate mechanical waves.
The invention also provides another microporous electrode for vascular calcification breaking treatment, which is characterized in that:
comprises a saccule, wherein a liquid medium is filled in the saccule; a catheter penetrates through the balloon, an anode conductive wire is arranged in the catheter, and an insulating layer is arranged on the outer surface of the anode conductive wire; the surface of the insulating layer is provided with a metal coating which is a discharge cathode. Further comprising a first discharge micro-hole and a second discharge micro-hole; the first discharge micropore and the second discharge micropore penetrate through the guide pipe, the metal coating and the insulating layer; the anode conductive wire is communicated with the liquid medium in the balloon through the anode discharge hole.
Preferably, the first discharge micro-hole and the second discharge micro-hole are oppositely arranged.
Preferably, the anode conductive wire is a metal conductive wire with a high melting point.
Preferably, the discharge cathode and the anode conductive wire are connected with a pulse power supply, and the discharge cathode and the anode conductive wire can discharge electricity in a liquid medium in the balloon to generate mechanical waves under the driving of the pulse power supply.
Preferably, the conduit, the metal coating, the insulating layer and the anode conductive wire are coaxially arranged.
The invention has the advantages that:
(1) the micropore electrode provided by the invention has the advantages of simple structure, low manufacturing cost and stable discharge.
(2) The micropore electrode provided by the invention has longer service life and reduced use cost.
(3) The micropore electrode provided by the invention has high electric energy conversion efficiency, and can generate mechanical waves with higher energy efficiency for vascular calcification treatment.
Drawings
FIG. 1 is a cross-sectional view of a parallel microporous electrode;
FIG. 2 is an effect diagram of a parallel type microporous electrode;
FIG. 3 is an effect view of a parallel type microporous electrode contained in a balloon;
FIG. 4 is a cross-sectional view of a parallel microporous electrode;
FIG. 5 is an effect diagram of a parallel type micro-porous electrode;
fig. 6 is an effect diagram of the parallel type micropore electrode accommodated in the balloon.
Wherein: 1-balloon, 2-catheter, 3-cathode conductive wire, 4-anode conductive wire, 5-insulating layer, 6-first through hole, 7-second through hole, 8-third through hole, 9-metal coating, 10-first discharge micropore and 11-second discharge micropore.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention more apparent, the technical solutions of the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings of the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be obtained by a person skilled in the art without any inventive step based on the embodiments of the present invention, are within the scope of the present invention. Thus, the following detailed description of the embodiments of the present invention, presented in the figures, is not intended to limit the scope of the invention, as claimed, but is merely representative of selected embodiments of the invention.
Aiming at the requirement of vascular calcification treatment, the invention provides a microporous electrode for breaking a vascular calcification layer by using a liquid-phase pulse discharge plasma technology.
The microporous electrode for the vascular calcification disruption treatment provided by the invention comprises two structures, namely a parallel structure and a coaxial structure.
A micropore electrode for the treatment of calcification and fragmentation of blood vessels, refer to fig. 1 to fig. 3, this is a parallel micropore electrode, including sacculus 1, the sacculus 1 is filled with the liquid medium; the balloon 1 is internally provided with a catheter 2 in a penetrating manner, the catheter 2 is internally provided with a cathode conductive wire 3 and an anode conductive wire 4, and the outer surface of the anode conductive wire 4 is wrapped with an insulating layer 5. The cathode conductive wire 3 and the anode conductive wire 4 are arranged in parallel in the conduit 2.
A first through hole 6 and a second through hole 7 are arranged on the wall of the guide pipe 2, and the first through hole 6 is a cathode discharge hole; a third through hole 8 is formed in the insulating layer 5, and the second through hole 7 is communicated with the third through hole 8 to form an anode discharge hole together; the cathode conductive wire 3 is communicated with the liquid medium in the balloon 1 through a cathode discharge hole; the anode conductive wire 4 is communicated with the liquid medium in the balloon 1 through an anode discharge hole.
The cathode conductive wire 3 and the anode conductive wire 4 are connected with a pulse power supply, and the cathode conductive wire 3 and the anode conductive wire 4 are driven by the pulse power supply to discharge electricity in a liquid medium in the balloon 1 to generate mechanical waves including shock waves and sound waves. The mechanical waves are conducted through the balloon to the calcified layer.
In a preferred embodiment of the present invention, the cathode discharge hole and the anode discharge hole are oppositely disposed.
As a preferred embodiment of the present invention, the cathode conductive filament 3 and the anode conductive filament 4 are both high melting point metal conductive filaments.
Example 1
Referring to fig. 1 to 3, the microporous electrode for the vascular calcification breaking treatment comprises a balloon 1, a catheter 2 penetrates through the balloon 1, and the interior of the balloon 1 is filled with a liquid medium. A cathode conductive wire 3 and an anode conductive wire 4 are arranged in the conduit 2, and an insulating layer 5 is wrapped on the outer surface of the anode conductive wire 4. The cathode conductive wire 3 and the anode conductive wire 4 are both high-melting-point metal conductive wires and are arranged in parallel in the catheter 2.
A first through hole 6 and a second through hole 7 are arranged on the wall of the guide pipe 2, and the first through hole 6 is a cathode discharge hole; a third through hole 8 is formed in the insulating layer 5, and the second through hole 7 is communicated with the third through hole 8 to form an anode discharge hole together; the cathode conductive wire 3 is communicated with the liquid medium in the balloon 1 through a cathode discharge hole; the anode conductive wire 4 is communicated with the liquid medium in the balloon 1 through an anode discharge hole. The cathode discharge hole and the anode discharge hole are oppositely arranged.
The cathode conductive wire 3 and the anode conductive wire 4 are connected with a pulse power supply, and the cathode conductive wire 3 and the anode conductive wire 4 are driven by the pulse power supply to discharge electricity in a liquid medium in the balloon 1 to generate mechanical waves including shock waves and sound waves. The mechanical waves are conducted through the balloon to the calcified layer.
Another microporous electrode for vascular calcification breaking treatment, which is shown in fig. 4 to 6, is a coaxial microporous electrode and comprises a balloon 1, wherein a liquid medium is filled in the balloon 1; the balloon 1 penetrates through the catheter 2, an anode conductive wire 4 is arranged in the catheter 2, and an insulating layer 5 is arranged on the outer surface of the anode conductive wire 4; the outer surface of the insulating layer 5 is provided with a metal coating 9, and the metal coating 9 is a discharge cathode. And further includes a first discharge micro-hole 10 and a second discharge micro-hole 11. The first discharge micro-hole 10 and the second discharge micro-hole 11 are both formed through the guide tube 2, the metal coating 9 and the insulating layer 5; the anode conductive wire 4 is communicated with the liquid medium in the balloon 1 through an anode discharge hole. The guide pipe 2, the metal coating 9, the insulating layer 5 and the anode conductive wire 4 are coaxially arranged.
As a preferred embodiment of the present invention, the first discharge micro-hole 10 and the second discharge micro-hole 11 are oppositely disposed.
As a preferred embodiment of the present invention, the anode conductive wire 4 is a metal conductive wire with a high melting point.
As a preferred embodiment of the invention, the discharge cathode and anode conductive wires 4 are connected with a pulse power supply, and the discharge cathode and anode conductive wires 4 can discharge electricity in the liquid medium in the balloon 1 to generate mechanical waves under the driving of the pulse power supply.
Example 2
Referring to fig. 4 to 6, a microporous electrode for vascular calcification breaking treatment comprises a balloon 1, wherein the balloon 1 is filled with a liquid medium; a catheter 2 penetrates through the balloon 1, and the catheter 2 is internally provided with: anode conductive wire 4, insulating layer 5, metal coating 9. The metal coating 9 is a discharge cathode. The first discharge micropore 10 and the second discharge micropore 11 are oppositely arranged and both penetrate through the guide pipe 2, the metal coating 9 and the insulating layer 5; the anode conductive wire 4 is communicated with the liquid medium in the balloon 1 through an anode discharge hole. The guide pipe 2, the metal coating 9, the insulating layer 5 and the anode conductive wire 4 are coaxially arranged. The anode conductive wire 4 is a metal conductive wire with a high melting point.
The discharge cathode and anode conductive wires 4 are connected with a common pulse power supply, and the discharge cathode and anode conductive wires 4 can discharge electricity in a liquid medium in the balloon 1 to generate mechanical waves under the driving of the pulse power supply.
The microporous electrode provided by the invention can utilize liquid phase pulse discharge plasma to generate mechanical waves such as shock waves, sound waves and the like in blood vessels. The microporous electrode is mounted within the balloon. The balloon is filled with a required solution medium, the balloon is filled with pressure, and mechanical waves generated by the liquid-phase pulse discharge plasma are transmitted to the vascular calcification layer through the balloon. Due to the characteristics of shock wave and sound wave propagation, the shock wave generated by liquid-phase pulse discharge can be transmitted to the superficial layer, the middle layer and the deep layer of the vascular calcification, so that the full vascular calcification can be broken and treated.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all equivalent structures or equivalent flow transformations made by using the contents of the specification and the drawings, or applied directly or indirectly to other related systems, are included in the scope of the present invention.
Claims (10)
1. A microporous electrode for vascular calcification disruption therapy, comprising:
comprises a balloon (1), wherein a liquid medium is filled in the balloon (1);
a catheter (2) penetrates through the balloon (1), a cathode conductive wire (3) and an anode conductive wire (4) are arranged in the catheter (2), and an insulating layer (5) is arranged on the outer surface of the anode conductive wire (4);
a first through hole (6) and a second through hole (7) are formed in the wall of the guide pipe (2), and the first through hole (6) is a cathode discharge hole; a third through hole (8) is formed in the insulating layer (5), and the second through hole (7) and the third through hole (8) are communicated to form an anode discharge hole together;
the cathode conductive wire (3) is communicated with a liquid medium in the balloon (1) through a cathode discharge hole;
the anode conductive wire (4) is communicated with the liquid medium in the balloon (1) through an anode discharge hole.
2. A microporous electrode for vascular calcification disruption treatment as defined in claim 1, wherein:
the cathode conductive wire (3) and the anode conductive wire (4) are arranged in parallel in the conduit (2).
3. A microporous electrode for vascular calcification disruption treatment as defined in claim 2, wherein:
the cathode discharge hole and the anode discharge hole are oppositely arranged.
4. A microporous electrode for vascular calcification disruption treatment as defined in claim 3, wherein:
the cathode conductive wire (3) and the anode conductive wire (4) are both high-melting-point metal conductive wires.
5. A microporous electrode for vascular calcification disruption treatment as defined in claim 4, wherein:
the cathode conductive wire (3) and the anode conductive wire (4) are connected with a pulse power supply, and the cathode conductive wire (3) and the anode conductive wire (4) are driven by the pulse power supply to discharge electricity in a liquid medium in the balloon (1) to generate mechanical waves.
6. A microporous electrode for vascular calcification disruption therapy, comprising:
comprises a balloon (1), wherein a liquid medium is filled in the balloon (1);
the balloon (1) penetrates through the catheter (2), an anode conductive wire (4) is arranged in the catheter (2), and an insulating layer (5) is arranged on the outer surface of the anode conductive wire (4); a metal coating (9) is arranged on the outer surface of the insulating layer (5), and the metal coating (9) is a discharge cathode;
further comprising a first discharge micro-hole (10) and a second discharge micro-hole (11);
the first discharge micropore (10) and the second discharge micropore (11) penetrate through the guide pipe (2), the metal coating (9) and the insulating layer (5);
the anode conductive wire (4) is communicated with the liquid medium in the balloon (1) through an anode discharge hole.
7. A microporous electrode for vascular calcification disruption treatment as defined in claim 6, wherein:
the first discharge micropore (10) and the second discharge micropore (11) are arranged oppositely.
8. A microporous electrode for vascular calcification disruption treatment as defined in claim 7, wherein:
the anode conductive wire (4) is a metal conductive wire with a high melting point.
9. A microporous electrode for vascular calcification disruption treatment as defined in claim 8, wherein:
the discharge cathode and anode conductive wires (4) are connected with a pulse power supply, and the discharge cathode and anode conductive wires (4) can discharge electricity in a liquid medium in the balloon (1) to generate mechanical waves under the driving of the pulse power supply.
10. A microporous electrode for vascular calcification disruption treatment as defined in claim 9, wherein:
the guide pipe (2), the metal coating (9), the insulating layer (5) and the anode conductive wire (4) are coaxially arranged.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111500131.2A CN114305652A (en) | 2021-12-09 | 2021-12-09 | Micropore electrode for blood vessel calcification breaking treatment |
| PCT/CN2022/137651 WO2023104164A1 (en) | 2021-12-09 | 2022-12-08 | Microporous electrode for disruption treatment of vascular calcification |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202111500131.2A CN114305652A (en) | 2021-12-09 | 2021-12-09 | Micropore electrode for blood vessel calcification breaking treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114305652A true CN114305652A (en) | 2022-04-12 |
Family
ID=81050615
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202111500131.2A Pending CN114305652A (en) | 2021-12-09 | 2021-12-09 | Micropore electrode for blood vessel calcification breaking treatment |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN114305652A (en) |
| WO (1) | WO2023104164A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023104164A1 (en) * | 2021-12-09 | 2023-06-15 | 深圳先进技术研究院 | Microporous electrode for disruption treatment of vascular calcification |
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| JPH06125915A (en) * | 1992-10-21 | 1994-05-10 | Inter Noba Kk | Catheter type medical instrument |
| CN108452426A (en) * | 2018-03-16 | 2018-08-28 | 上海心至医疗科技有限公司 | A kind of foley's tube based on electrohydraulic effect |
| CN111388086A (en) * | 2020-06-08 | 2020-07-10 | 上海微创医疗器械（集团）有限公司 | Electrode balloon catheter |
| CN111601560A (en) * | 2017-11-17 | 2020-08-28 | 冲击波医疗公司 | Low profile electrode for a shock waveguide |
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| CN214966283U (en) * | 2020-12-16 | 2021-12-03 | 深圳市赛禾医疗技术有限公司 | Pressure wave sacculus pipe |
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| US10702293B2 (en) * | 2008-06-13 | 2020-07-07 | Shockwave Medical, Inc. | Two-stage method for treating calcified lesions within the wall of a blood vessel |
| US9642673B2 (en) * | 2012-06-27 | 2017-05-09 | Shockwave Medical, Inc. | Shock wave balloon catheter with multiple shock wave sources |
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| WO2016109736A1 (en) * | 2014-12-30 | 2016-07-07 | The Spectranetics Corporation | Laser-induced fluid filled balloon catheter |
| NL2019807B1 (en) * | 2017-10-26 | 2019-05-06 | Boston Scient Scimed Inc | Shockwave generating device |
| CN113648048A (en) * | 2021-07-15 | 2021-11-16 | 深圳市赛禾医疗技术有限公司 | Shock wave balloon catheter system with controllable discharge |
| CN114305652A (en) * | 2021-12-09 | 2022-04-12 | 深圳先进技术研究院 | Micropore electrode for blood vessel calcification breaking treatment |
-
2021
- 2021-12-09 CN CN202111500131.2A patent/CN114305652A/en active Pending
-
2022
- 2022-12-08 WO PCT/CN2022/137651 patent/WO2023104164A1/en unknown
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH06125915A (en) * | 1992-10-21 | 1994-05-10 | Inter Noba Kk | Catheter type medical instrument |
| CN111601560A (en) * | 2017-11-17 | 2020-08-28 | 冲击波医疗公司 | Low profile electrode for a shock waveguide |
| CN108452426A (en) * | 2018-03-16 | 2018-08-28 | 上海心至医疗科技有限公司 | A kind of foley's tube based on electrohydraulic effect |
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| CN214966283U (en) * | 2020-12-16 | 2021-12-03 | 深圳市赛禾医疗技术有限公司 | Pressure wave sacculus pipe |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023104164A1 (en) * | 2021-12-09 | 2023-06-15 | 深圳先进技术研究院 | Microporous electrode for disruption treatment of vascular calcification |
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| WO2023104164A1 (en) | 2023-06-15 |
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