CN102238918A - Micro-emulsifier for arterial thrombus removal - Google Patents

Micro-emulsifier for arterial thrombus removal Download PDF

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Publication number
CN102238918A
CN102238918A CN2008801318103A CN200880131810A CN102238918A CN 102238918 A CN102238918 A CN 102238918A CN 2008801318103 A CN2008801318103 A CN 2008801318103A CN 200880131810 A CN200880131810 A CN 200880131810A CN 102238918 A CN102238918 A CN 102238918A
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transmission line
miniature
emulsator
piezoelectric
shape portion
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CN102238918B (en
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马元
刘发浩
梅彦昌
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Nanyang Technological University
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
    • A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B06—GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
    • B06B—METHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
    • B06B1/00—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency
    • B06B1/02—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy
    • B06B1/06—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
    • B06B1/0607—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction using multiple elements
    • B06B1/0611—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction using multiple elements in a pile
    • G—PHYSICS
    • G10—MUSICAL INSTRUMENTS; ACOUSTICS
    • G10K—SOUND-PRODUCING DEVICES; METHODS OR DEVICES FOR PROTECTING AGAINST, OR FOR DAMPING, NOISE OR OTHER ACOUSTIC WAVES IN GENERAL; ACOUSTICS NOT OTHERWISE PROVIDED FOR
    • G10K11/00—Methods or devices for transmitting, conducting or directing sound in general; Methods or devices for protecting against, or for damping, noise or other acoustic waves in general
    • G10K11/02—Mechanical acoustic impedances; Impedance matching, e.g. by horns; Acoustic resonators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
    • A61B2017/22001—Angioplasty, e.g. PCTA

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  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Mechanical Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
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  • Apparatuses For Generation Of Mechanical Vibrations (AREA)

Abstract

Disclosed is a micro-emulsifier comprising a stack of piezoelectric materials, a horn at a proximal end of the stack of piezoelectric materials, and a transmission wire receivable in the horn for transmission of ultrasound waves able to be produced by the stack of piezoelectric materials. The ultrasound waves are able to be produced in a direction parallel to a longitudinal axis of the stack of piezoelectric materials and the horn. The transmission wire comprises a first end receivable in the horn and a second end remote from the first end, the second end having a bulb thereon.

Description

Be used for the miniature emulsator that arterial thrombus removes
Technical field
The present invention relates to be used for the miniature emulsator that arterial thrombus removes, and particularly, although be not uniquely, ultrasonic disappear molten (ablation) of the thrombosis of the miniaturized piezoelectric transducer of finger by having flexible transmission line, and the emulsifying that refers to biological substance, for example ultrasonic emulsification of thrombosis (phacoemulsification).
Background technology
Thrombosis is the blood clot that forms in blood vessel and rest in the blood vessel.This can cause damage, destroy (infraction) in this zone, perhaps even the death of organizing (necrosis).The thrombosis surgical operation is common way.Developed and to be used for the many different operation tool that thrombosis removes.These instruments comprise by the use of mechanical force, thrombolytic agent (Thrombolytic agent) and the instrument that ultrasonic energy removes thrombosis.Yet there are numerous shortcomings in these technology, comprise, but are not limited to poor efficiency and to the damage of blood vessel wall.
Developed and be used for the thromboembolism molten piezo-electric device that disappears.Actuator has the external generator that produces the desired electric energy of ultrasonic energy for the actuator supply.The crystalline transducer of lead zirconate titanate (" PZT ") is converted into high-power ultrasonic with electric energy.The ultrasound catheter that is connected the transducer near-end with ultrasonic transmission to target thrombosis at its far-end.Molten by disappearing of ultransonic thrombosis is to act on by the cavitation in blood clot (cavitation) that is caused by ultrasound wave.
The ultrasonic tissue molten tissue selectivity that presents that disappears.Biological tissue is inversely proportional to the sensitivity of ultrasound destruction and their elastical retraction power, and elastical retraction power is represented by their collagen protein and elastin laminin content.Although thrombosis itself does not more have the elasticity element, they to ultrasonic disappear molten extremely sensitive.On the contrary, be rich in collagen protein and elastin compliance (compliant) substrate normal arterial wall then relatively to ultrasonic disappear molten insensitive.Because cavitation is a biological selectivity, aorta wall has resistant function to cavitation, only has thrombosis to be disappeared molten by above-mentioned actuator.
The example that ultrasound catheter is used for the treatment of human blood vessel is that the solution that will contain dissolved compound directly is delivered to inaccessible site, to remove or to reduce obturation.In addition, ultrasonic energy is generated by ultrasonic assembly, and is used to strengthen the therapeutical effect of dissolved compound.Owing to only have conduit to be inserted in the blood vessel, and transducer is external, and the input power that needs will be high, to provide enough ultrasonic energy to being used for thromboclastic conduit.Equally, because the length of the length of conduit, will be high along the energy loss of conduit.This means that efficient will reduce because of energy loss.
Another example uses TCD,transcranial Doppler thromboembolism system, the effectiveness that the ultrasonic energy that this system uses and thrombolytic agent makes up comes assist in dissolving intracranial thrombosis and strengthens thrombolytic agent.Yet the large scale of system has limited its practical application.
An example again of supersonic medicine device is used to treat deep venous thrombosis, by using the ultrasonic energy that has a plurality of horizontal node (node) and antinode (anti-nodes) along the longitudinal axis of ultrasonic probe, to produce cavitation, thrombus dissolving and treatment deep venous thrombosis disappear.Cell around laterally supersonic vibration may damage, and be not only thrombosis.Equally, owing to only have conduit to be inserted in the body, its ability that is positioned to thrombosis is relatively poor.
Prior art does not provide suitable will be inserted into disappear molten, the emulsifying and remove thrombosis of intravital device.Prior art does not provide as the desired thrombosis site that navigates to preferably in the mankind's application to have the solution of higher degree of accuracy.Prior art uses high input power to generate the low frequency ultrasound energy.They all suffer big energy loss in conversion process.Thus, still exist needs, so that can be inserted in the body and molten, the emulsifying and remove thrombosis of can disappearing to undersized equipment.This is the mode more to localize preferably.
Summary of the invention
According to first illustrative aspects, a kind of miniature emulsator is provided, comprises the piezoelectric that stacks, in the horn shape portion of the described piezoelectric near-end that stacks, and can be received in the transmission line that is used for hyperacoustic transmission in the described horn shape portion, described ultrasound wave can be produced by the described piezoelectric that stacks.Described ultrasound wave can produce in the direction of the longitudinal axis that is parallel to described piezoelectric that stacks and described horn shape portion.
According to another illustrative aspects, a kind of miniature emulsator is provided, comprises the piezoelectric that stacks, in the horn shape portion of the described piezoelectric near-end that stacks, and can be received in the transmission line that is used for hyperacoustic transmission in the described horn shape portion, described ultrasound wave can be produced by the described piezoelectric that stacks.Described transmission line comprises first end that can be received in the described horn shape portion and away from second end of described first end, described second end has globular part thereon.
At first illustrative aspects, described transmission line can comprise first end that can be received in the described horn shape portion and away from second end of described first end, described second end has globular part thereon.
According to an illustrative aspects again, a kind of transmission line that is used for miniature emulsator is provided, described transmission line comprises first end in the horn shape portion that is constructed to be received in described miniature emulsator, and away from second end of described first end, described second end has globular part thereon.
At whole three illustrative aspects, described globular part is for becoming one with described second end and being fixed at least a in described second end.Described globular part can have slick outer surface.Described outer surface can be irregular shape or sphere.Described transmission line can be flexible; And can be metal material.
At preceding two illustrative aspects, described ultrasound wave can be to produce in the direction of the longitudinal axis that is parallel to described piezoelectric that stacks and described horn shape portion.The described piezoelectric that stacks can comprise a plurality of piezoelectric elements.Each piezoelectric element can include the cylinder of hollow core.Each piezoelectric element can periodically compress and expand in the direction of the longitudinal axis that is parallel to described piezoelectric that stacks and described horn shape portion.Described horn shape portion can be a hollow pipe, and can receive the described transmission line that is used for the transmission of longitudinal ultrasonic ripple therein.Described transmission line can be received with compression fit or the mode that is clasped.Described transmission line can use fixative and/or sealant with engaging of described horn shape portion.Replacedly, described transmission line can be an one with described horn shape portion.
Described miniature emulsator can be suitable in the main blood vessel by appearance, and described transmission line can be located in be used for disappearing of described little blood vessel thrombosis in the little blood vessel molten.
According to last illustrative aspects, a kind of method of the thrombus dissolving that disappears in first blood vessel is provided, described method comprises: transmit aforesaid miniature emulsator along the trunk that can hold suitable described miniature emulsator and contact described thrombosis in the described trunk up to described transmission line, perhaps enter less blood vessel and contact thrombosis in the described less blood vessel, actuate described miniature emulsator with the ultrasonic energy that generates portrait orientation at the described globular part molten described thrombosis that disappears.It can be at least a by cavitation and Mechanical Crushing that described thrombosis described disappears molten.Disappear and moltenly can comprise emulsifying, reorganization and thromboembolism.
Description of drawings
For the present invention can be understood and easily actual the execution all sidedly, should describe by the mode of indefiniteness embodiment now, described indefiniteness embodiment is an exemplary only, reference will be made to the accompanying drawings.
In the accompanying drawing: Fig. 1 is the sketch map of the exemplary of miniature emulsator;
Fig. 2 is vertical vertical cross-section of transducer of the exemplary of Fig. 1;
Fig. 3 is the sketch map of transmission line of the exemplary of Fig. 1 and 2;
Fig. 4 is the contraction of piezoelectric of the diagram exemplary that is used for Fig. 1 and 2 and the sketch map of expansion; And
Fig. 5 is the diagram by vertical waveform of the operation generation of the exemplary of Fig. 1 to 4.
The specific embodiment
Shown in Fig. 1 to 3 is the miniature emulsator 10 that comprises transducer 20 and transmission line 40.
Transducer 20 is converted into the large power supersonic energy with electric energy, and comprises a pair of electrical lead 21 of electric energy to transducer 20 that be used to supply.Replacedly, can in transducer 20, provide built-in or removable battery.Again replacedly, rf wave can be used to come supplying energy via the built-in antenna (not shown) in the transducer 20.Go out as shown, lead-in wire 21 far-ends 27 at transducer 20 are connected to the main body 26 of transducer 20.
The main body 26 of transducer 20 also comprises actuator coil 22 and the piezoelectric 28 that stacks 23.Each that stacks 23 piezoelectric 28 can be lead zirconate titanate (" PZT ") crystal.As shown in Figure 4, each that stacks 23 piezoelectric 28 preferably has the cylinder of hollow core 29.Each piezoelectric 28 shrinks and expansion in the direction of the center longitudinal axis 30 of transducer 20.Stack 23 piezoelectric 28 by having, promoted the multilamellar amplification, thereby piezoelectric stack 23 plays amplifier.Stack 23 although describe and illustrate, also can use single ring 28 or pipe (long ring).This can be helpful when miniature emulsator 10 will be by further miniaturization.
The diameter of piezoelectric stack 23 can be, for example 5mm, and length can be, for example 8mm.In this way, miniature emulsator 10 can be placed in the main blood vessel.
At its near-end 31, the main body 26 of transducer 20 has the horn shape portion 24 of form known and such as the structure of hollow pipe, goes out as shown.24 transmission of horn shape portion are also amplified ultrasonic energy to transmission line 40, and be installed to main body 26 by means of horn shape portion pedestal 25.Horn shape portion 24 is hollow pipes and is used for receiving therein transmission line 40.The diameter of horn shape portion 24 can be that for example 1.5mm, and its length can be for example to arrive in the scope of 30mm 20.
Horn shape portion 24 can be any suitable material, for example 7075 aluminums.Aluminum has low-density, and this helps the hyperacoustic amplification by transducer 20 generations.This quality that also means piezoelectric stack 23 is relatively bigger than the quality of horn shape portion 24.
If piezoelectric stack 23 has quality m 1, and with formation speed v 1, and horn shape portion has quality m 2, and with formation speed v 2, then because the conversion of energy,
m 1v 1＝m 2v 2
Because m 1Greater than m 2, so v 2Will be greater than v 1This has promoted amplification effect.Because by the amplitude little (being caused by its size and physical property) that piezoelectric stack 23 generates, the hyperacoustic amplifier that is produced by piezoelectric stack 23 will serve as in horn shape portion 24.
Transmission line 40 has second end 42 that is used to be installed in first end 41 in the horn shape portion 24 and has head 43 thereon.Transmission line 40 transmission ultrasonic energies are to the target thrombosis at second end 42.Transmission line 40 has the ultrasound wave that concentrates on head 43.
Transmission line 40 is connected the near-end of horn shape portion 24, and can have 0.3 in the 0.7mm scope, the diameter of 0.5mm preferably.The length of transmission line 40 can arrive in the 40cm scope 10, preferably 15cm.The length of transmission line 40 is short more, and energy loss is few more, and efficient is good more.The length of transmission line 40 is passed through to determine (n*1/2 λ, wherein n is an integer) by the wavelength of the frequency of transducer 20 generations.
Second end 42 of transmission line 40 has globular part 43, and this globular part 43 preferably has slick shape and can be spherical haply.It can be an one with transmission line 40, perhaps can be attached to transmission line 40 securely.This globular part 43 can be, polymer (as epoxy resin) for example, and can have 1.0 in the 2.0mm scope, the diameter of 1.5mm preferably.This makes transmission line to extend to the little blood vessel (for example coronary artery) from transducer 20.So, transducer 20 can be retained in larger diameter and can hold in suitable its blood vessel, and transmission line 40 can extend to the ultrasonic emulsification that is used for thrombosis in the blood vessel than minor diameter.
Globular part 43 is parts of the contact thrombosis of miniature emulsator 10.Even and slick plane 44 is preferred.Illustrated ball shape can increase the contact area with thrombosis.Smooth surface 44 help to prevent insert and/or operating period to the damage of blood vessel wall.Surface 44 can be heterogeneous, to increase the friction on surface 44, to strengthen the ultrasonic emulsification of thrombosis.Transmission line is preferably flexible, thereby it can be along the path of blood vessel to reach the site of thrombosis.
Transmission line 40 preferably has the material of the crystalline texture that is suitable for hyperacoustic transmission.So, this transmission line 40 is preferably metal, more preferably hard metal.This transmission line 40 also is preferably flexible.Because ultrasonic energy is in solid metal or transmit preferably by solid metal, transmission line 40 is preferably, for example rustless steel or titanium.Because miniature emulsator 10 is inserted in the body, material must be suitable for this purpose.Titanium, Ti-6Al-4V (grade 5) are with excellent biocompatibility and with 1E+7 circulation high-fatigue strength (K t=3.3) be used.Titanium, Ti-6Al-4V (grade 5) also have high flexible, so that it can be crooked in being inserted into blood vessel the time and changes shape.
Being connected of transmission line 40 and horn shape portion 24 can be inserted in the horn shape portion 24 with compression fit or the mode that is clasped and/or can use fixing and/or sealant (for example epoxy resin, welding, or like that) by transmission line 40.Connection should be such, to minimize the loss of ultrasonic energy 40 the transmission from horn shape portion 24 to transmission line.Good sealing will be helpful in this respect between transmission line 40 and the horn shape portion 24.Replacedly, transmission line 40 can be an one with horn shape portion 24.
What the cylinder essence that stacks 23 piezoelectric element 28 was induced piezoelectric element 28 passes through preface contraction and expansion, to produce the ultrasound wave of portrait orientation, as shown in Figure 5.Ultrasound wave can have for example 20 in the 100KHz scope, the frequency of 60KHz preferably.
Include the combination of two kinds of synergistic mechanisms in molten by disappearing of 10 pairs of thrombosis of miniature emulsator.First kind of mechanism is cavitation.Between the negative phase in acoustics cycle, pressure is reduced to below the vapour pressure of thrombosis.So, the high ultrasonic energy that is applied can cause the formation of microvesicle in the thrombosis or cavity.The local assault ripple can generate with caving in by the Rapid Expansion in chamber.The violent relatively implosion of microvesicle or cavity can cause disorganization.Cavitation is confirmed by following discovery the ultransonic molten active role that disappears, and observes when promptly tissue disappears the molten only power more than cavitation threshold.
The Mechanical Crushing of target thrombosis is second mechanism.This is to be caused by the altofrequency that produces because of ultrasound wave of the globular part 44 of transmission line 40, the length travel of short arc.Yet, the extra transverse movement of transmission line 40, perhaps extra cavitation also may take place simultaneously.
As if because thrombosis breaks more responsively to ultrasonic, this has hinted that cavitation is the thrombosis molten dominant mechanism that disappears.Cavitation causes the depolymerization of fiber polymer, causes the thrombosis fragmentation thus.
Whole miniature emulsator 10 all can be inserted in the blood vessel, rather than as the only conduit or the transmission line of prior art.This has increased efficient.Transmission line 40 length, intensity and flexible, with globular part 44, make miniature emulsator to be transmitted, than the thrombosis in the trunk, perhaps enter less blood vessel and contact thrombosis in the less blood vessel up to the transmission line contact along holding suitable its bigger blood vessel.Hyperacoustic vertical essence rather than the transverse sound wave thrombus dissolving that can disappear with minimal damage risk to the wall of little blood vessel.This can have lower input power and higher efficient.
Miniature emulsator 10 can be placed on the tip of standard vacuum conduit, allows to send towards the smooth of thrombosis site.Near thrombosis, miniature emulsator 10 will be actuated, and generate the ultrasonic energy of the portrait orientation of the thrombus dissolving that will disappear at globular part 44.Device generates ultrasonic energy partly, and therefore in human body is used higher degree of accuracy is arranged.These will be simplified procedures in itself and reduce side effect.
Disappearing of thrombosis moltenly is considered to comprise emulsifying, separates fragmentation (defragmentation), thromboembolism, or the like.It can take place by two kinds of different behaviors:
(a) mechanical shock.Here the vibrations of globular part 44 will be pulverized thrombosis.This is propagated even without ripple on, and thrombosis also can be destroyed.Reason for this reason, the transmission line 40 big length that do not have.
(b) cavitation: ultrasonic energy is propagated in thrombosis as, emulsifying molten by disappearing, the pressure of separating fragmentation, thromboembolism or the like destruction thrombosis and/or stress wave here.
Miniature emulsator 10 can be used to, for example:
The dissipation of grumeleuse (lysis) in aorta and the bifurcated artery thereof;
The dissipation of grumeleuse in the coronary artery;
The dissipation of grumeleuse in the Venous system;
The improvement of blood flow in the cardiac muscle;
The dissipation of grumeleuse in the cerebrovascular: and
The dissipation of grumeleuse in the pulmonary artery.
Although exemplary has been described in the preamble explanation, it will be understood by those skilled in the art that in the details of design, structure and/or operation and can carry out many variations, and do not depart from the present invention.

Claims (21)

1. miniature emulsator, comprise the piezoelectric that stacks, horn shape portion at the described piezoelectric near-end that stacks, and can be received in the transmission line that is used for hyperacoustic transmission in the described horn shape portion, described ultrasound wave can be produced by the described piezoelectric that stacks, and described ultrasound wave can produce in the direction of the longitudinal axis that is parallel to described piezoelectric that stacks and described horn shape portion.
2. miniature emulsator, comprise the piezoelectric that stacks, horn shape portion at the described piezoelectric near-end that stacks, and can be received in the transmission line that is used for hyperacoustic transmission in the described horn shape portion, described ultrasound wave can be produced by the described piezoelectric that stacks, described transmission line comprises first end that can be received in the described horn shape portion and away from second end of described first end, described second end has globular part thereon.
3. miniature emulsator as claimed in claim 1, wherein said transmission line comprise first end that can be received in the described horn shape portion and away from second end of described first end, described second end has globular part thereon.
4. miniature emulsator as claimed in claim 2, wherein said globular part is for becoming one with described second end and being fixed at least a in described second end.
5. as each described miniature emulsator in the claim 2 to 4, wherein said globular part has slick outer surface.
6. miniature emulsator as claimed in claim 4, wherein said outer surface are the shape that is selected from by irregular shape and the spherical group of forming.
7. as each described miniature emulsator in the claim 1 to 6, wherein said transmission line is flexible, and is metal material.
8. miniature emulsator as claimed in claim 2, wherein said ultrasound wave can produce in the direction of the longitudinal axis that is parallel to described piezoelectric that stacks and described horn shape portion.
9. as each described miniature emulsator in the claim 1 to 8, the wherein said piezoelectric that stacks comprises a plurality of piezoelectric elements, and each piezoelectric element includes the cylinder of hollow core.
10. be subordinated to claim 1 or 8 o'clock described miniature emulsators as claim 9, wherein each piezoelectric element periodically compresses and expands in the direction of the longitudinal axis that is parallel to described piezoelectric that stacks and described horn shape portion.
11. as each described miniature emulsator in the claim 1 to 10, wherein said horn shape portion is the pipe of hollow, and receive the described transmission line that is used for the transmission of longitudinal ultrasonic ripple therein, described transmission line is received to be selected from by the mode of compression fit with the group formed of being clasped; Described transmission line uses at least a of fixative and sealant with engaging of described horn shape portion.
12. as each described miniature emulsator in the claim 1 to 10, wherein said transmission line and described horn shape portion become one.
13. as each described miniature emulsator in the claim 1 to 12, wherein said miniature emulsator can be held and is suitable in the main blood vessel, and described transmission line can be located in be used for disappearing of described little blood vessel thrombosis in the little blood vessel molten.
14. a transmission line that is used for miniature emulsator, described transmission line comprise first end in the horn shape portion that is constructed to be received in described miniature emulsator, and away from second end of described first end, described second end has globular part thereon.
15. transmission line as claimed in claim 14, wherein said globular part is for becoming one with described second end and being attached at least a in described second end securely.
16. as claim 14 or 15 described transmission lines, wherein said globular part has slick outer surface.
17. transmission line as claimed in claim 16, wherein said outer surface are the shape that is selected from by irregular shape and the spherical group of forming.
18. as each described transmission line in the claim 14 to 17, wherein said transmission line is flexible, and is to be used for the material of longitudinal ultrasonic ripple along described transmission line to described globular part transmission.
19. the method for the thrombus dissolving that in first blood vessel, disappears, described method comprises: along the trunk transmission that can hold suitable described miniature emulsator as each described miniature emulsator in the claim 1 to 13 up to as described in the transmission line contact than the thrombosis in the trunk, perhaps enter less blood vessel and contact thrombosis in the described less blood vessel, actuate described miniature emulsator with the ultrasonic energy that generates portrait orientation at the described globular part molten described thrombosis that disappears.
20. it is at least a by cavitation and Mechanical Crushing that method as claimed in claim 19, wherein said thrombosis described disappear molten.
21. as claim 19 or 20 described methods, wherein disappearing moltenly comprises emulsifying, separates fragmentation and thromboembolism.
CN200880131810.3A 2008-09-03 2008-09-03 Micro-emulsifier for arterial thrombus removal Active CN102238918B (en)

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106137258A (en) * 2016-06-27 2016-11-23 中国科学院苏州生物医学工程技术研究所 Miniature ultrasonic device
CN106214216A (en) * 2016-08-31 2016-12-14 赵萍萍 A kind of thrombosis removes instrument
CN110251850A (en) * 2019-05-13 2019-09-20 中国科学院苏州生物医学工程技术研究所 A kind of ultrasound thrombolysis probe and ultrasound thrombolysis method
WO2023241182A1 (en) * 2022-06-14 2023-12-21 深圳腾复医疗科技有限公司 Ultrasonic transducer for assisting in thrombolysis, and ultrasound-generating apparatus comprising same

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5419761A (en) * 1993-08-03 1995-05-30 Misonix, Inc. Liposuction apparatus and associated method
US20030036705A1 (en) * 1999-10-05 2003-02-20 Omnisonics Medical Technologies, Inc. Ultrasonic probe device having an impedance mismatch with rapid attachment and detachment means
US20070066978A1 (en) * 2005-09-06 2007-03-22 Schafer Mark E Ultrasound medical devices and related methods
US20080039746A1 (en) * 2006-05-25 2008-02-14 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions
US7374551B2 (en) * 2003-02-19 2008-05-20 Pittsburgh Plastic Surgery Research Associates Minimally invasive fat cavitation method

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4750902A (en) * 1985-08-28 1988-06-14 Sonomed Technology, Inc. Endoscopic ultrasonic aspirators
CA2165829A1 (en) * 1993-07-01 1995-01-19 John E. Abele Imaging, electrical potential sensing, and ablation catheters
US6283974B1 (en) * 1997-11-14 2001-09-04 Aaron James Alexander Surgical tip for phacoemulsification

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5419761A (en) * 1993-08-03 1995-05-30 Misonix, Inc. Liposuction apparatus and associated method
US20030036705A1 (en) * 1999-10-05 2003-02-20 Omnisonics Medical Technologies, Inc. Ultrasonic probe device having an impedance mismatch with rapid attachment and detachment means
US7374551B2 (en) * 2003-02-19 2008-05-20 Pittsburgh Plastic Surgery Research Associates Minimally invasive fat cavitation method
US20070066978A1 (en) * 2005-09-06 2007-03-22 Schafer Mark E Ultrasound medical devices and related methods
US20080039746A1 (en) * 2006-05-25 2008-02-14 Medtronic, Inc. Methods of using high intensity focused ultrasound to form an ablated tissue area containing a plurality of lesions

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106137258A (en) * 2016-06-27 2016-11-23 中国科学院苏州生物医学工程技术研究所 Miniature ultrasonic device
CN106214216A (en) * 2016-08-31 2016-12-14 赵萍萍 A kind of thrombosis removes instrument
CN106214216B (en) * 2016-08-31 2019-01-25 赵萍萍 A kind of thrombus removing instrument
CN110251850A (en) * 2019-05-13 2019-09-20 中国科学院苏州生物医学工程技术研究所 A kind of ultrasound thrombolysis probe and ultrasound thrombolysis method
WO2023241182A1 (en) * 2022-06-14 2023-12-21 深圳腾复医疗科技有限公司 Ultrasonic transducer for assisting in thrombolysis, and ultrasound-generating apparatus comprising same

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