CN102238918B - Micro-emulsifier for arterial thrombus removal - Google Patents
Micro-emulsifier for arterial thrombus removal Download PDFInfo
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- CN102238918B CN102238918B CN200880131810.3A CN200880131810A CN102238918B CN 102238918 B CN102238918 B CN 102238918B CN 200880131810 A CN200880131810 A CN 200880131810A CN 102238918 B CN102238918 B CN 102238918B
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- 239000003995 emulsifying agent Substances 0.000 title claims abstract description 40
- 208000007536 Thrombosis Diseases 0.000 title claims description 53
- 230000005540 biological transmission Effects 0.000 claims abstract description 67
- 238000002604 ultrasonography Methods 0.000 claims abstract description 17
- 239000000463 material Substances 0.000 claims abstract description 8
- 210000004204 blood vessel Anatomy 0.000 claims description 16
- 230000006378 damage Effects 0.000 claims description 7
- 230000006835 compression Effects 0.000 claims description 3
- 238000007906 compression Methods 0.000 claims description 3
- 239000000565 sealant Substances 0.000 claims description 3
- 239000000834 fixative Substances 0.000 claims description 2
- 230000001788 irregular Effects 0.000 claims description 2
- 239000007769 metal material Substances 0.000 claims description 2
- 230000001804 emulsifying effect Effects 0.000 description 6
- 208000005189 Embolism Diseases 0.000 description 5
- 208000001435 Thromboembolism Diseases 0.000 description 5
- 238000010586 diagram Methods 0.000 description 5
- 238000006243 chemical reaction Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 4
- 239000003527 fibrinolytic agent Substances 0.000 description 4
- 229910052451 lead zirconate titanate Inorganic materials 0.000 description 4
- 230000007246 mechanism Effects 0.000 description 4
- 229910052751 metal Inorganic materials 0.000 description 4
- 239000002184 metal Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 229960000103 thrombolytic agent Drugs 0.000 description 4
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000004945 emulsification Methods 0.000 description 3
- 239000010936 titanium Substances 0.000 description 3
- 229910052719 titanium Inorganic materials 0.000 description 3
- 102000008186 Collagen Human genes 0.000 description 2
- 108010035532 Collagen Proteins 0.000 description 2
- 206010051055 Deep vein thrombosis Diseases 0.000 description 2
- 102000016942 Elastin Human genes 0.000 description 2
- 108010014258 Elastin Proteins 0.000 description 2
- 229910000883 Ti6Al4V Inorganic materials 0.000 description 2
- 206010047249 Venous thrombosis Diseases 0.000 description 2
- 235000010210 aluminium Nutrition 0.000 description 2
- 230000003321 amplification Effects 0.000 description 2
- 210000000709 aorta Anatomy 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 210000004351 coronary vessel Anatomy 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 229920002549 elastin Polymers 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000003822 epoxy resin Substances 0.000 description 2
- HFGPZNIAWCZYJU-UHFFFAOYSA-N lead zirconate titanate Chemical compound [O-2].[O-2].[O-2].[O-2].[O-2].[Ti+4].[Zr+4].[Pb+2] HFGPZNIAWCZYJU-UHFFFAOYSA-N 0.000 description 2
- 238000003199 nucleic acid amplification method Methods 0.000 description 2
- 229920000647 polyepoxide Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 201000001429 Intracranial Thrombosis Diseases 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 238000002679 ablation Methods 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 230000009089 cytolysis Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 230000017074 necrotic cell death Effects 0.000 description 1
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 1
- 230000000704 physical effect Effects 0.000 description 1
- 210000001147 pulmonary artery Anatomy 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 238000001356 surgical procedure Methods 0.000 description 1
- 230000002195 synergetic effect Effects 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000002537 thrombolytic effect Effects 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B17/22004—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves
- A61B17/22012—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for using mechanical vibrations, e.g. ultrasonic shock waves in direct contact with, or very close to, the obstruction or concrement
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B06—GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS IN GENERAL
- B06B—METHODS OR APPARATUS FOR GENERATING OR TRANSMITTING MECHANICAL VIBRATIONS OF INFRASONIC, SONIC, OR ULTRASONIC FREQUENCY, e.g. FOR PERFORMING MECHANICAL WORK IN GENERAL
- B06B1/00—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency
- B06B1/02—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy
- B06B1/06—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction
- B06B1/0607—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction using multiple elements
- B06B1/0611—Methods or apparatus for generating mechanical vibrations of infrasonic, sonic, or ultrasonic frequency making use of electrical energy operating with piezoelectric effect or with electrostriction using multiple elements in a pile
-
- G—PHYSICS
- G10—MUSICAL INSTRUMENTS; ACOUSTICS
- G10K—SOUND-PRODUCING DEVICES; METHODS OR DEVICES FOR PROTECTING AGAINST, OR FOR DAMPING, NOISE OR OTHER ACOUSTIC WAVES IN GENERAL; ACOUSTICS NOT OTHERWISE PROVIDED FOR
- G10K11/00—Methods or devices for transmitting, conducting or directing sound in general; Methods or devices for protecting against, or for damping, noise or other acoustic waves in general
- G10K11/02—Mechanical acoustic impedances; Impedance matching, e.g. by horns; Acoustic resonators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
- A61B17/22—Implements for squeezing-off ulcers or the like on the inside of inner organs of the body; Implements for scraping-out cavities of body organs, e.g. bones; Calculus removers; Calculus smashing apparatus; Apparatus for removing obstructions in blood vessels, not otherwise provided for
- A61B2017/22001—Angioplasty, e.g. PCTA
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- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Mechanical Engineering (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medical Informatics (AREA)
- Animal Behavior & Ethology (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Physics & Mathematics (AREA)
- Acoustics & Sound (AREA)
- Multimedia (AREA)
- Surgical Instruments (AREA)
- Apparatuses For Generation Of Mechanical Vibrations (AREA)
Abstract
Disclosed is a micro-emulsifier comprising a stack of piezoelectric materials, a horn at a proximal end of the stack of piezoelectric materials, and a transmission wire receivable in the horn for transmission of ultrasound waves able to be produced by the stack of piezoelectric materials. The ultrasound waves are able to be produced in a direction parallel to a longitudinal axis of the stack of piezoelectric materials and the horn. The transmission wire comprises a first end receivable in the horn and a second end remote from the first end, the second end having a bulb thereon.
Description
Technical field
The present invention relates to the micro-emulsifier removed for arterial thrombus, and particularly, although also non-uniquely, refer to ultrasonic disappear molten (ablation) of the thrombosis of the miniaturized piezoelectric transducer by having flexible transmission line, and refer to the emulsifying of biological substance, the ultrasonic emulsification (phacoemulsification) of such as thrombosis.
Background technology
Thrombosis is the blood clot being formed in the blood vessel and stop in the blood vessel.This can cause damage in this region, destroy (infraction), or the death even organized (necrosis).Throracic surgeries operation is common way.Develop the many different operation tool removed for thrombosis.These instruments comprise the instrument being removed thrombosis by the use of mechanical force, thrombolytic agent (Thrombolytic agent) and ultrasonic energy.But these technology exist numerous shortcoming, include, but are not limited to poor efficiency and the damage to blood vessel wall.
Develop and to have disappeared molten piezo-electric device for thromboembolism.Actuator has the external generator of the electric energy required by actuator supply generation ultrasonic energy.Electric energy conversion is high-power ultrasonic by the transducer of lead zirconate titanate (" PZT ") crystal.The ultrasound catheter being connected to transducer near-end by ultrasonic transmission to the target thrombosis at its far-end.By ultrasonic thrombosis disappear molten be by being caused by ultrasound wave the cavitation (cavitation) in blood clot effect.
Ultrasonic tissue disappears and moltenly presents tissue selectivity.Biological tissue is inversely proportional to the sensitivity of ultrasound destruction and their elastic recovery force, and elastic recovery force is represented by their collagen protein and elastin laminin content.Although the less flexible element of thrombosis itself, they to ultrasonic disappear molten extremely sensitive.On the contrary, the normal arterial wall being rich in compliance (compliant) substrate of collagen protein and elastin then relatively to ultrasonic disappear molten insensitive.Because cavitation is biological selectivity, aorta wall has resistant function to cavitation, only has thrombosis to be disappeared molten by above-mentioned actuator.
The example that ultrasound catheter is used for the treatment of Human vascular is that the solution containing dissolved compound is directly delivered to occlusion site, to remove or to reduce obturation.In addition, ultrasonic energy is generated by ultrasonic assembly, and is used to the therapeutical effect strengthening dissolved compound.Owing to only there being conduit to be inserted in blood vessel, and transducer in vitro, and the input power of needs will be high, to provide enough ultrasonic energy to for thromboclastic conduit.Equally, due to the length of the length of conduit, the energy loss along conduit will be high.This means that efficiency will reduce because of energy loss.
Another example uses TCD,transcranial Doppler thromboembolism system, and this system uses the ultrasonic energy combined with thrombolytic agent to carry out assist in dissolving Intracranial thrombus and strengthen the effect of thrombolytic agent.But the large scale of system limits its practical application.
An example again of supersonic medicine device is used to treat deep venous thrombosis, by the ultrasonic energy using the longitudinal axis along ultrasonic probe to have multiple horizontal node (node) and antinode (anti-nodes), to produce cavitation, disappear thrombus dissolving and treatment deep venous thrombosis.Horizontal supersonic vibration may damage the cell of surrounding, and is not only thrombosis.Equally, owing to only there being conduit to be inserted in body, its ability being positioned to thrombosis is poor.
Prior art does not provide suitable will be inserted into device in body to disappear molten, emulsifying and remove thrombosis.Prior art does not provide and navigates to thrombus site preferably to have the solution of higher degree of accuracy as required in the application of the mankind.Prior art uses high input power to generate low frequency ultrasound energy.They all suffer large energy loss in conversion process.Thus, still there are the needs to undersized equipment, can be inserted in body and molten, the emulsifying and remove thrombosis of can disappearing.This is preferably in the mode more localized.
Summary of the invention
According to the first illustrative aspects, a kind of micro-emulsifier is provided, comprises the piezoelectric stacked, in the horn of the described piezoelectric near-end stacked, and the transmission line that can be received in for hyperacoustic transmission in described horn, described ultrasound wave can be produced by the described piezoelectric stacked.The direction of the longitudinal axis of the piezoelectric that described ultrasound wave can stack described in being parallel to and described horn produces.
According to another illustrative aspects, a kind of micro-emulsifier is provided, comprises the piezoelectric stacked, in the horn of the described piezoelectric near-end stacked, and the transmission line that can be received in for hyperacoustic transmission in described horn, described ultrasound wave can be produced by the described piezoelectric stacked.Described transmission line comprises can be received in the first end in described horn and the second end away from described first end, and described second end has globular part thereon.
For the first illustrative aspects, described transmission line can comprise can be received in the first end in described horn and the second end away from described first end, and described second end has globular part thereon.
According to an illustrative aspects again, a kind of transmission line for micro-emulsifier is provided, described transmission line comprises the first end being constructed to can be received in the horn of described micro-emulsifier, and away from the second end of described first end, described second end has globular part thereon.
For whole three illustrative aspects, described globular part is become to be integrated with described second end and be fixed at least one in described second end.Described globular part can have smooth outer surface.Described outer surface can be irregular shape or spherical.Described transmission line can be flexible; And can be metal material.
For the first two illustrative aspects, described ultrasound wave can be that the direction of the longitudinal axis of piezoelectric and the described horn that can stack described in being parallel to produces.The described piezoelectric stacked can comprise multiple piezoelectric element.Each piezoelectric element can include the cylinder of hollow core.The direction of the longitudinal axis of the piezoelectric that each piezoelectric element can stack described in being parallel to and described horn is periodically compressed and expands.Described horn can be hollow pipe, and can receive the described transmission line for the transmission of longitudinal ultrasonic ripple wherein.Described transmission line can be received with compression fit or the mode be clasped.The joint of described transmission line and described horn can use fixative and/or sealant.Alternatively, described transmission line can be integrated with described horn.
Described micro-emulsifier can be suitable in Major Vessels by appearance, and described transmission line can be located in thin vessels molten for disappearing of thrombosis in described thin vessels.
According to last illustrative aspects, a kind of method of the thrombus dissolving that disappears in the first blood vessel is provided, described method comprises: along holding the trunk transmission micro-emulsifier as above of suitable described micro-emulsifier until described transmission line contacts the described thrombosis in described trunk, or enter compared with thin vessels and contact described compared with the thrombosis in thin vessels, actuating described micro-emulsifier to generate the ultrasonic energy of portrait orientation to the molten described thrombosis that disappears at described globular part.Disappearing molten described in described thrombosis can be at least one by cavitation and Mechanical Crushing.Disappear and moltenly can comprise emulsifying, restructuring and thromboembolism.
Accompanying drawing explanation
Can be more fully understood to make the present invention and easily actual execution, should be described by the mode of nonlimiting examples now, described nonlimiting examples is only exemplary, and reference will be made to the accompanying drawings.
In accompanying drawing: Fig. 1 is the schematic diagram of the exemplary of micro-emulsifier;
Fig. 2 is longitudinal vertical cross-section of the transducer of the exemplary of Fig. 1;
Fig. 3 is the schematic diagram of the transmission line of the exemplary of Fig. 1 and 2;
Fig. 4 is that diagram is for the contraction of the piezoelectric of the exemplary of Fig. 1 and 2 and the schematic diagram of expansion; And
Fig. 5 is the diagram of the longitudinal waveform produced by the operation of the exemplary of Fig. 1 to 4.
Detailed description of the invention
Shown in Fig. 1 to 3 is the micro-emulsifier 10 comprising transducer 20 and transmission line 40.
Electric energy conversion is large power supersonic energy by transducer 20, and comprises a pair for supplying the electrical lead 21 of electric energy to transducer 20.Alternatively, built-in or removable battery can be provided in transducer 20.Again alternatively, rf wave can be used to carry out supplying energy via the built-in antenna (not shown) in transducer 20.As shown, lead-in wire 21 is connected to the main body 26 of transducer 20 at the far-end 27 of transducer 20.
The main body 26 of transducer 20 also comprises actuator coil 22 and stacks the piezoelectric 28 of 23.Each stacking the piezoelectric 28 of 23 can be lead zirconate titanate (" PZT ") crystal.As shown in Figure 4, each stacking the piezoelectric 28 of 23 preferably has the cylinder of hollow core 29.Each piezoelectric 28 shrinks in the direction of the center longitudinal axis 30 of transducer 20 and expansion.By having the piezoelectric 28 stacking 23, facilitate multilamellar and amplify, thus piezoelectric stack 23 playing amplifier.Although describe and illustrate and stack 23, single ring 28 or pipe (long ring) also can be used.This will by can be helpful during further miniaturization at micro-emulsifier 10.
The diameter of piezoelectric stack 23 can be, such as 5mm, and length can be, such as 8mm.In this way, micro-emulsifier 10 can be placed in Major Vessels.
At its near-end 31, the main body 26 of transducer 20 has the horn 24 of form known and the structure of such as hollow pipe, as shown.Horn 24 is transmitted and is amplified ultrasonic energy to transmission line 40, and is installed to main body 26 by means of horn pedestal 25.Horn 24 is hollow pipe and for receiving transmission line 40 wherein.The diameter of horn 24 can be, such as 1.5mm, and its length can be, such as, in 20 scopes to 30mm.
Horn 24 can be any suitable material, such as 7075 aluminums.Aluminum has low-density, and this contributes to the hyperacoustic amplification produced by transducer 20.This also means that the quality of piezoelectric stack 23 is relatively larger than the quality of horn 24.
If piezoelectric stack 23 has quality m
1, and by formation speed v
1, and horn has quality m
2, and by formation speed v
2, then due to the conversion of energy,
m
1v
1＝m
2v
2
Due to m
1be greater than m
2, therefore v
2v will be greater than
1.This facilitate amplification effect.Due to the amplitude little (being caused by its size and physical property) generated by piezoelectric stack 23, horn 24 will serve as the hyperacoustic amplifier produced by piezoelectric stack 23.
Transmission line 40 has the first end 41 for being arranged in horn 24 and has the second end 42 of head 43 thereon.Transmission line 40 transmits ultrasonic energy to the target thrombosis at the second end 42.Transmission line 40 has the ultrasound wave concentrating on head 43.
Transmission line 40 is connected the near-end of horn 24, and can have 0.3 within the scope of 0.7mm, the diameter of preferably 0.5mm.The length of transmission line 40 can within the scope of 10 to 40cm, preferably 15cm.The length of transmission line 40 is shorter, and energy loss is fewer, and efficiency is better.The length of transmission line 40 is determined (n*1/2 λ, wherein n is integer) by the wavelength of the frequency generated by transducer 20.
Second end 42 of transmission line 40 has globular part 43, and this globular part 43 preferably has smooth shape and can haply for spherical.It can be integrated with transmission line 40, or can be attached to transmission line 40 securely.This globular part 43 can be, such as polymer (as epoxy resin), and can have 1.0 within the scope of 2.0mm, the diameter of preferably 1.5mm.This makes transmission line can extend to thin vessels (such as coronary artery) from transducer 20.So, transducer 20 can be retained in larger diameter and can hold in its blood vessel suitable, and transmission line 40 can extend to the ultrasonic emulsification for thrombosis in the blood vessel of small diameter.
Globular part 43 is parts of the contact thrombosis of micro-emulsifier 10.Even and smooth plane 44 is preferred.Illustrated ball shape can increase the contact area with thrombosis.Smooth surface 44 contributes to preventing the damage inserting and/or to blood vessel wall during operation.Surface 44 can be heterogeneous, to increase the friction on surface 44, to strengthen the ultrasonic emulsification of thrombosis.Transmission line is preferably flexible, thus it can along the path of blood vessel to reach the site of thrombosis.
Transmission line 40 preferably has the material of the crystalline texture being suitable for hyperacoustic transmission.So, this transmission line 40 is preferably metal, is more preferably hard metal.This transmission line 40 is also preferably flexible.Because ultrasonic energy is in solid metal or transmit best by solid metal, transmission line 40 is preferably, such as rustless steel or titanium.Because micro-emulsifier 10 is inserted in body, material must be suitable for this object.Titanium, Ti-6Al-4V (grade 5) are with the biocompatibility of excellence and with the high-fatigue strength (K of 1E+7 circulation
t=3.3) used.Titanium, Ti-6Al-4V (grade 5) also have high flexibility, can bend to make it and change shape when being inserted in blood vessel.
The connection of transmission line 40 and horn 24 can be inserted in horn 24 with compression fit or the mode that is clasped by transmission line 40 and/or can use fixing and/or sealant (such as epoxy resin, weld, or like this).Connection should be such, to minimize the loss of ultrasonic energy in from horn 24 to the transmission of transmission line 40.Sealing good between transmission line 40 and horn 24 will be helpful in this respect.Alternatively, transmission line 40 can be integrated with horn 24.
The sequence of passing through stacking the cylinder essence induced piezoelectric element 28 of the piezoelectric element 28 of 23 is shunk and expansion, to produce the ultrasound wave of portrait orientation, as shown in Figure 5.Ultrasound wave can have such as 20 within the scope of 100KHz, the frequency of preferably 60KHz.
By micro-emulsifier 10 pairs of thrombosis disappear molten in include the combination of two kinds of synergistic mechanisms.The first mechanism is cavitation.Between the negative phase of acoustic cycle, pressure is reduced to below the vapour pressure of thrombosis.So, the high ultrasonic energy applied can cause the formation of microvesicle or cavity in thrombosis.Local assault ripple and can cave in and generate by the Rapid Expansion in chamber.The relatively violent implosion of microvesicle or cavity can cause disorganization.Cavitation is confirmed by following discovery the ultrasonic molten active role that disappears, and namely organizes when disappearing molten power only more than cavitation threshold and observes.
The Mechanical Crushing of target thrombosis is the second mechanism.This is caused by the altofrequency produced because of ultrasound wave of the globular part 44 of transmission line 40, the length travel of short arc.But the extra transverse movement of transmission line 40, or extra cavitation, also may occur simultaneously.
Because thrombosis seems more responsive to sonic disruption, which imply the dominant mechanism that cavitation is Thrombolysis.Cavitation causes the depolymerization of fiber polymer, causes thrombosis broken thus.
Whole micro-emulsifier 10 all can be inserted in blood vessel, instead of as the only conduit of prior art or transmission line.Which increase efficiency.Transmission line 40 length, intensity and flexibility, together with globular part 44, micro-emulsifier can be passed along holding the larger blood vessel of fitting it, until transmission line contact is compared with the thrombosis in trunk, or enters compared with thin vessels and contact compared with the thrombosis in thin vessels.Hyperacoustic longitudinally essence instead of transverse sound wave can to disappear thrombus dissolving with the minimal damage risk of the wall to thin vessels.This can have lower input power and higher efficiency.
Micro-emulsifier 10 can be placed on the tip of standard vacuum conduit, allows to send towards the smooth of thrombus site.Near thrombosis, micro-emulsifier 10 will be actuated, and generate the ultrasonic energy of the portrait orientation of the thrombus dissolving that disappears at globular part 44.Device generates ultrasonic energy partly, and therefore in human body application, has higher degree of accuracy.These will be simplified procedures in itself and reduce side effect.
Molten being considered to that disappear of thrombosis comprises emulsifying, separates broken (defragmentation), thromboembolism, etc.It can pass through two kinds of different behavior generations:
(a) mechanical shock.Here the vibrations of globular part 44 will pulverize thrombosis.This on, even without wave traveling, thrombosis also can be destroyed.Reason for this reason, transmission line 40 does not have large length.
(b) cavitation: ultrasonic energy destroys the pressure of thrombosis and/or stress wave as, thromboembolism broken by molten, the emulsifying of disappearing, solution etc. and propagates in thrombosis here.
Micro-emulsifier 10 can be used to, such as:
The dissipation (lysis) of grumeleuse in aorta and bifurcated artery thereof;
The dissipation of grumeleuse in coronary artery;
The dissipation of grumeleuse in Venous system;
The improvement of heart intramuscular blood-stream;
The dissipation of grumeleuse in cerebrovascular: and
The dissipation of grumeleuse in pulmonary artery.
Although illustrate above and described exemplary, it will be understood by those skilled in the art that design, build and/or operation details in can carry out many changes, and do not depart from the present invention.
Claims (11)
1. a micro-emulsifier, described micro-emulsifier comprises transducer, and described micro-emulsifier comprises: actuator coil, an only piezoelectric element, described only piezoelectric element includes the cylinder of hollow core, described in have the cylinder of hollow core to be configured to shrink on the longitudinal axis of described transducer and expansion, in the horn of described piezoelectric element near-end, described horn is hollow pipe, and the transmission line that can be received in for hyperacoustic transmission in described horn, described ultrasound wave can be produced by described piezoelectric element, described ultrasound wave can produce in the direction of the longitudinal axis being parallel to described piezoelectric element and described horn, described transmission line comprises can be received in the first end in described horn and the second end away from described first end, described second end has the globular part for contacting the thrombosis in blood vessel thereon, wherein said micro-emulsifier is configured to whole described micro-emulsifier and is inserted in blood vessel and near thrombosis, produces ultrasonic energy partly with the molten described thrombosis that disappears.
2. micro-emulsifier as claimed in claim 1, wherein said globular part also contributes to preventing to insert the damage of period to blood vessel wall in described blood vessel at described transmission line.
3. micro-emulsifier as claimed in claim 1 or 2, wherein said globular part is become to be integrated with described second end and be fixed at least one in described second end.
4. micro-emulsifier as claimed in claim 1 or 2, wherein said globular part has smooth outer surface.
5. micro-emulsifier as claimed in claim 4, wherein said outer surface is the shape be selected from by irregular shape and the spherical group formed.
6. micro-emulsifier as claimed in claim 1 or 2, wherein said transmission line is flexible, and is metal material.
7. micro-emulsifier as claimed in claim 1, wherein said piezoelectric element periodically compresses in the direction of the longitudinal axis being parallel to described piezoelectric element and described horn and expands.
8. micro-emulsifier as claimed in claim 1 or 2, wherein said transmission line can be received in described horn to be selected from by compression fit and the mode of the group formed that is clasped; The joint of described transmission line and described horn uses at least one of fixative and sealant.
9. micro-emulsifier as claimed in claim 1 or 2, wherein said transmission line becomes to be integrated with described horn.
10. micro-emulsifier as claimed in claim 1 or 2, wherein said micro-emulsifier can hold and is suitable in Major Vessels, and described transmission line can be located in thin vessels molten for disappearing of thrombosis in described thin vessels.
11. micro-emulsifiers as claimed in claim 1, wherein said transmission line is flexible, and is the material that transmits along described transmission line to described globular part for longitudinal ultrasonic ripple.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/SG2008/000323 WO2010027325A1 (en) | 2008-09-03 | 2008-09-03 | Micro-emulsifier for arterial thrombus removal |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102238918A CN102238918A (en) | 2011-11-09 |
| CN102238918B true CN102238918B (en) | 2015-06-10 |
Family
ID=41797329
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN200880131810.3A Active CN102238918B (en) | 2008-09-03 | 2008-09-03 | Micro-emulsifier for arterial thrombus removal |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN102238918B (en) |
| AU (1) | AU2008361369B2 (en) |
| WO (1) | WO2010027325A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106137258A (en) * | 2016-06-27 | 2016-11-23 | 中国科学院苏州生物医学工程技术研究所 | Miniature ultrasonic device |
| CN106214216B (en) * | 2016-08-31 | 2019-01-25 | 赵萍萍 | A kind of thrombus removing instrument |
| CN110251850A (en) * | 2019-05-13 | 2019-09-20 | 中国科学院苏州生物医学工程技术研究所 | A kind of ultrasound thrombolysis probe and ultrasound thrombolysis method |
| WO2023241182A1 (en) * | 2022-06-14 | 2023-12-21 | 深圳腾复医疗科技有限公司 | Ultrasonic transducer for assisting in thrombolysis, and ultrasound-generating apparatus comprising same |
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| US5419761A (en) * | 1993-08-03 | 1995-05-30 | Misonix, Inc. | Liposuction apparatus and associated method |
| US7374551B2 (en) * | 2003-02-19 | 2008-05-20 | Pittsburgh Plastic Surgery Research Associates | Minimally invasive fat cavitation method |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010027325A1 (en) | 2010-03-11 |
| AU2008361369B2 (en) | 2016-04-14 |
| CN102238918A (en) | 2011-11-09 |
| AU2008361369A1 (en) | 2010-03-11 |
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