CN114272275A - Use of cocoa extract for the manufacture of a medicament for the treatment of hypotension - Google Patents
Use of cocoa extract for the manufacture of a medicament for the treatment of hypotension Download PDFInfo
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- CN114272275A CN114272275A CN202011068924.7A CN202011068924A CN114272275A CN 114272275 A CN114272275 A CN 114272275A CN 202011068924 A CN202011068924 A CN 202011068924A CN 114272275 A CN114272275 A CN 114272275A
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Abstract
The invention aims to provide a new application of cocoa extract, namely a new application in preparing a medicament for treating hypotension in human. The invention discloses a clinical application method and a curative effect of a cocoa extract as a medicament for treating human hypotension. The invention can condition the function of human body by oral administration of the cocoa powder beverage; treating hypotension in humans; and simultaneously, the life quality of hypotension patients is improved. Simple application method, obvious curative effect and low cost. In addition, each component of the cocoa extract is from natural plants, and has no obvious toxicity and side effect on human bodies.
Description
Technical Field
The invention relates to application of a compound in medicine, in particular to application of a cocoa extract in preparing a medicine for treating hypotension.
Background
Hypotension (hypotension) refers to a state in which systemic arterial pressure is below normal. There is no uniform standard for the diagnosis of hypotension. Hypotension is generally considered to be when the arterial blood pressure of the upper limb of an adult is less than 90/60 mmHg. Physiological and pathological hypotension can be classified according to the etiology, and acute and chronic hypotension can be classified according to the onset pattern.
Physiological hypotension state means that blood pressure measurement values of partial healthy people reach hypotension standards, but no subjective symptoms exist, and long-term follow-up shows that except low blood pressure, each system organ of a human body has no abnormality such as ischemia, anoxia and the like, and the life is not influenced.
Essential hypotension refers to a hypotension state without any obvious cause, such as physiological hypotension (constitutional hypotension), and is often found in the elderly and women with weak constitutions.
Secondary hypotension refers to a decrease in blood pressure caused by a disease of an organ or system of the human body. This hypotension can occur rapidly in a short period of time, such as a rapid decrease in blood pressure due to major bleeding, acute myocardial infarction, severe trauma, infection, allergy, and the like. In most cases, hypotension occurs slowly and can become progressively worse, such as hypotension secondary to severe tuberculosis, malignancy, malnutrition, cachexia, and the like.
Acute hypotension refers to a sudden and obvious decrease in blood pressure from a normal or higher level, and clinically, symptoms such as dizziness, eye blackness, limb weakness, cold sweat, palpitation, oliguria and the like are usually caused by ischemia of important organs such as brain, heart, kidney and the like, and severe symptoms are manifested as syncope or shock.
Chronic hypotension refers to a state in which blood pressure continues to fall below the normal range. It can be classified as (1) constitutional hypotension; (2) orthostatic hypotension; and (3) secondary hypotension.
Orthostatic hypotension refers to the occurrence of hypotension in some patients that is associated with postural changes (particularly, orthostatic), known as orthostatic hypotension. Orthostatic hypotension is defined as: within 3 minutes of changing posture to an upright position, systolic pressure drops > 20mmHg or diastolic pressure drops > 10mmHg with symptoms of hypoperfusion, including: dizziness, blurred vision, asthenia, nausea, cognitive dysfunction, palpitation, and pain in the neck and back.
The diagnosis of hypotension is based primarily on arterial blood pressure measurements to reach the hypotension criteria.
For people with weak constitution, nutrition needs to be strengthened; patients with orthostatic hypotension do not need to take care of taking care of not too hard when standing in a recumbent position or taking a hand to prevent the patients from falling down due to hypotension.
Properly strengthening exercise: life is regulated to prevent over-fatigue, as extreme fatigue causes lower blood pressure drop. To maintain a good mental state, to properly strengthen exercise, to improve physical fitness, to improve the regulation function of nerves and blood vessels, to accelerate blood circulation, and to reduce the onset of orthostatic hypotension.
Adjusting diet: it is not desirable to eat too full every meal because too full will result in a relative reduction in blood flow back to the heart. The drinking of light salt boiled water or the eating of slightly salty food can increase the water intake, and more water enters the blood to increase the blood volume, thereby improving the blood pressure. When drinking tea in proper amount, caffeine in tea can excite respiratory center and cardiovascular system.
Cocoa (cocoa) production begins in tropical regions near the equator where humid climates are well suited for cocoa tree planting. The world has 70% of cocoa beans from four countries in western africa: cotdeuva, garna, nigeria and karilon. To date, cotdet and gana are the two largest producing countries of cocoa: they have grown more than half of the world's cocoa together. These two countries are followed by other cocoa producing countries, such as indonesia, nigeria, karilon, brazil and ecuador.
Cocoa powder (cocoa powder) is prepared from cocoa beans (seeds) extracted from bean pods (fruits) of cocoa tree by fermenting, coarse crushing, peeling, and defatting and pulverizing cocoa cake to obtain powder. Cocoa powder is classified into cacao powder, indonesia cocoa powder, etc. according to the producing area. The cocoa powder is divided into high, medium and low fat cocoa powder according to the fat content; it is divided into natural powder and alkalized powder according to different processing methods. The cocoa powder has strong cocoa aroma, and can be used for high-grade chocolate, beverage, milk, ice cream, candy, cake and other cocoa-containing food.
It is believed to be the earliest used by maya civilization in central america. It was introduced into europe in the 16 th century by spain afflictors and rapidly received wide popularity as a health-promoting drug. Modern studies have shown that it does contain important compounds beneficial to the human body.
Cocoa is rich in polyphenols and has significant health benefits, including reduction of inflammation and improvement of cholesterol levels. However, processing cocoa into chocolate or other products can greatly reduce the polyphenol content
Cocoa fibers exhibit hypotensive potential: the soluble fiber product of cocoa is rich in soluble fiber, antioxidants and polyphenols. Such products are available from the inside of cocoa shells using the enzyme patented process.
The researchers showed that: the mechanism of action of cocoa soluble fiber in resisting blood pressure has not been fully elucidated and more research suggestions are needed. "therefore, further clinical trials must be conducted before the soluble cocoa cellulose acts as a functional drug to treat or slow the progression of hypertension. ", a
Studies have shown that cocoa is rich in flavanols and can lower blood pressure by improving nitric oxide levels and vascular function. Cocoa containing 30-1,218 mg flavanols reduced blood pressure by an average of 2 mmHg.
Cocoa can improve blood flow and reduce cholesterol. Eating a maximum of one serving per day may reduce the risk of heart attack, heart failure and stroke.
Flavanols in cocoa can support neuronal production, brain function, and improve blood flow and supply to brain tissue. They may play a role in preventing age-related brain degeneration, such as in alzheimer's disease, but more research is needed.
Cocoa can have some positive effects on mood and depression symptoms by: reduce stress levels and improve ballast, mental well-being and overall mental health. However, more research is required.
Cocoa and dark chocolate can reduce the risk of diabetes and maintain healthy blood glucose levels. However, there are some conflicting results in scientific evidence and more research is required.
Cocoa products are lighter in weight and can help lose weight by adding cocoa to the diet. However, more research on this subject is required to determine the desired type and amount.
Flavanols in cocoa have been shown to have convincing anticancer properties in both in vitro and animal studies, but data from human trials are lacking.
Cocoa extracts have shown certain anti-asthmatic properties in animal studies. However, human testing is required before they can be suggested as a therapeutic.
Cocoa is able to promote dental health by combating the bacteria that cause tooth decay, although this is not suitable for sugar-containing products. It can also promote skin health by protecting the skin from sunlight and improving blood circulation, and by hydrating the skin surface.
For heart health, 0.1 ounce (2.5 grams) of high flavone cocoa powder or 0.4 ounce (10 grams) of high flavone chocolate should be added to the patient's diet. The addition of cocoa can bring delicious chocolate taste to the dish.
Cocoa has been an important component of modern gourmet in the form of chocolate, which has been encumbered for thousands of years. Health benefits of cocoa include reduction of inflammation, improvement of heart and brain health, blood glucose and weight control, and dental and skin health. Rich in nutrition and can be easily added into diet by creative mode. However, if the health benefits are to be maximized, please ensure that non-alkalized cocoa or dark chocolate with cocoa content over 70% is used. Please remember that chocolate still contains a lot of sugar and fat, so if it is to be used, please adhere to a reasonable serving and combine it with a healthy balanced diet.
Disclosure of Invention
The invention aims to provide a new application of cocoa extract, namely a new application in preparing a medicament for treating hypotension in human.
Animal studies have shown that soluble cocoa fiber can reduce blood pressure and enhance heart health. It was found that cocoa shell extract rich in soluble fiber reduced systolic blood pressure of spontaneously hypertensive rats by 10-15 mmHg.
Studies have demonstrated that eating 1.4 to 105 grams of cocoa product for two weeks or more in adults without hypertension can reduce blood pressure by an average of 2 mmHg.
However, there is currently no clinical study on cocoa extracts as a drug for the treatment of hypotension in humans.
Secondary hypotension refers to a decrease in blood pressure caused by a disease of an organ or system of the human body. In most cases, hypotension occurs slowly and can become progressively worse, such as hypotension secondary to severe tuberculosis, malignancy, malnutrition, cachexia, and the like. It has been reported that many people living normally and actively continue to develop debilitating symptoms, including chronic fatigue, fever, nausea and vomiting and rapid heart rate fluctuations, months after new coronary pneumonia (Covid-19). Numerous researchers are studying the long-term effects of Covid-19 on patients around the world. One of the reasons for the continued appearance of debilitating symptoms may be hypotension secondary to new coronary pneumonia.
The invention discloses a clinical application method and a curative effect of cocoa powder for treating hypotension of human beings.
Detailed Description
To further illustrate the technical solution of the present invention, specific examples are illustrated below.
The cocoa powder used in this example was sold by Mark and Spencer, uk; can be used for baking pastry or making chocolate beverage. The purity of the cocoa powder is 100 percent.
The blood pressure and heart rate measurement in this embodiment uses an upper arm blood pressure monitor designed by OMRON healthcare limited, japan.
Clinical experiments
Through a volunteer clinical experiment of the inventor of the patent, the invention carries out detailed analysis on the case as follows:
female, age 53, residing in the uk. Patients with type 2 diabetes. Long-term oral administration of jasmine extract controls blood glucose levels in diabetes (metformin once taken orally causes severe adverse effects and side effects; thus western medicines are discontinued; patent application No. 201910448358.3). Daily life can be taken care of by oneself in general: scientific research is carried out on the Internet, housework is done at home, shopping and dining are carried out outside, relatives and friends are seen outside, and the like.
Patient fever in mid-5 th of 2020 (in uk); body temperature was above 38 ℃. There was no improvement after two days with Paracetamol (Paracetamol); the body temperature reached 38.9 ℃. The patient suspects that this is a Covid-19 attack and starts to take the copperflower antipyretic capsule. Then the body temperature returned to normal (36.3 ℃); and did not rise any more (further antibody checks were required to confirm whether the patient was indeed infected with Covid-19).
However, during the next three months, the patient's blood pressure is typically below 90/60mmHg and continues to drop, with a minimum recorded at 59/40 mmHg. At the same time, the heart rate was too high, approximately between 115 and 120/min, with a maximum score of 130/min. Sweating due to debility, not wanting to eat food, and vomiting frequently. The patient is so weak that the hand is weak to hold the mobile phone. And are more unable to sit or stand. Even when lying in bed, it is not possible to fall asleep because of intolerable discomfort.
Because the body temperature is normal, there are no dyspnea symptoms and the patient has not gone to the hospital. In addition, patients are also concerned about hospital infections with Covid-19.
In 8 months of 2020, the patient began using the cocoa powder beverage provided by the present invention to treat hypotension.
The preparation method of the cocoa powder beverage comprises the following steps: placing 5 ml of cocoa powder and 5 ml of sugar in a cup; adding boiling water until the mixture is filled with water; stirring; milk (about 300 ml) was added; and (5) standby.
The method for taking the cocoa powder beverage in the first treatment comprises the following steps: once a day; 11 in the morning: 00 for drinking; blood pressure was measured before drinking. If the blood pressure is lower than 90/60mmHg, 300 milliliters of the tea is drunk at one time. 5 minutes after drinking; blood pressure was measured one hour after drinking and three more times at night before going to bed. For example: the patient measured a blood pressure of 59/40mmHg prior to drinking; drinking 300 ml of cocoa powder beverage; blood pressure was measured at 92/60mmHg 5 minutes after drinking and 107/68mmHg one hour after drinking; the blood pressure was measured at 111/73mmHg before going to bed at night.
The following method for determining the dose of the cocoa powder beverage in treatment comprises the following steps: once a day; 11 in the morning: 00 drink. (a) Measuring blood pressure before drinking; if it is less than 90/60 mmHg; and the blood pressure measured after all three drinks on the previous day was below 140/80 mmHg; 300 ml is drunk at one time. (b) Measuring blood pressure before drinking; if 90/60mmHg is exceeded; but below 105/70mmHg and the blood pressure measured after all three drinks of the previous day was below 145/85 mmHg; decrement as appropriate; the drink is 100 ml and 200 ml at a time. (c) Measuring blood pressure before drinking; if 105/70mmHg is exceeded; or measuring blood pressure above 145/85mmHg after any one drink on the previous day; drinking of the cocoa beverage was stopped completely for one day.
Since each person has a different physical condition, the actual blood pressure control value of each person should be different. But the treatment principle is the same: with the increase of blood pressure, the dosage of the cocoa powder beverage is reduced as appropriate; drinking of cocoa drink should be stopped completely when blood pressure will enter the hypertensive zone.
After two weeks of treatment; the patient stopped drinking the cocoa beverage completely. The next two weeks; the patient's blood pressure measurement is between 115/75mmHg to 145/85 mmHg; with heart rate between 85/min and 100/min.
After one month of treatment; the symptoms of sweating and vomiting disappeared in this patient. Diet and sleep were restored to normal. Physical strength is increased, and indoor daily life can be managed by oneself: scientific research, making calls, watching television, and doing some minor housework is done on the internet.
The mechanism of action of cocoa powder as an anti-hypotensive drug in humans is currently unknown. According to a large number of literature studies and the in-person drug testing of the inventor, the cocoa powder beverage provided by the invention can be used for treating hypotension relatively safely; this may be due to the following factors: hypotensive symptoms are a disorder of the heart and blood circulation system of the human body; cocoa powder may contain some trace chemical elements which act as catalysts; can activate and restart to recover the function of the cardiovascular system of the human body.
The medical clinical experiment proves that:
cocoa powder has the function of being used as an anti-hypotensive drug for human beings.
Cocoa powder is used as a food for baking cakes or making chocolate drinks in the market; has no obvious toxicity and side effect on human body.
The oral cocoa powder beverage can improve the life quality of hypotension patients.
The action mechanism of cocoa powder as a medicament for resisting hypotension in human is not clarified, and more research suggestions are needed.
In conclusion, the invention can regulate the functions of the human body by orally taking the cocoa powder beverage; treating hypotension in humans; and simultaneously improves the life quality of the patients. The application method is simple; has obvious curative effect and low cost. In addition, each component of the cocoa extract is from natural plants, has no obvious toxicity and side effect on human bodies, meets the condition of the invention patent, and the invention patent application is proposed according to law.
Claims (7)
1. A novel medicament for the treatment of hypotension characterized by: cocoa powder is the effective component of the new medicine for treating hypotension.
2. A novel medicament for the treatment of hypotension characterized by: cocoa powder is the main component of the new medicine for treating hypotension.
3. A novel medicament for the treatment of hypotension characterized by: cocoa extract is the effective component of the new medicine for treating hypotension.
4. A novel medicament for the treatment of hypotension characterized by: cocoa extract is the main ingredient of the new medicine for treating hypotension.
5. The novel medicament according to claims 1.2.3 and 4 for the treatment of hypotension characterized by: the medicine is prepared into all pharmaceutically allowable dosage forms.
6. A new compound medicine is prepared by adding other auxiliary medicinal materials on the basis of a cocoa extract medicinal material for treating hypotension, and is characterized in that the cocoa extract dosage of the new compound medicine for treating hypotension is 0.1-50 g per person per day.
7. The novel combination as claimed in claim 6, for use in the treatment of hypotension, wherein: the medicine is prepared into all pharmaceutically allowable dosage forms.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011068924.7A CN114272275A (en) | 2020-09-27 | 2020-09-27 | Use of cocoa extract for the manufacture of a medicament for the treatment of hypotension |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202011068924.7A CN114272275A (en) | 2020-09-27 | 2020-09-27 | Use of cocoa extract for the manufacture of a medicament for the treatment of hypotension |
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| CN202011068924.7A Pending CN114272275A (en) | 2020-09-27 | 2020-09-27 | Use of cocoa extract for the manufacture of a medicament for the treatment of hypotension |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103635095A (en) * | 2011-04-28 | 2014-03-12 | 赫尔希公司 | Cocoa nuggets and method of making same |
| CN104383407A (en) * | 2014-11-17 | 2015-03-04 | 孙丰卿 | Traditional Chinese medicine composition for treating hypotension and preparation method of preparation of traditional Chinese medicine composition |
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2020
- 2020-09-27 CN CN202011068924.7A patent/CN114272275A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103635095A (en) * | 2011-04-28 | 2014-03-12 | 赫尔希公司 | Cocoa nuggets and method of making same |
| CN104383407A (en) * | 2014-11-17 | 2015-03-04 | 孙丰卿 | Traditional Chinese medicine composition for treating hypotension and preparation method of preparation of traditional Chinese medicine composition |
Non-Patent Citations (1)
| Title |
|---|
| 吕风华主编,: "《新编心脏内科学》", 上海交通大学出版社, pages: 486 * |
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