CN114269734B - Jak抑制剂 - Google Patents

Jak抑制剂

Info

Publication number
CN114269734B
CN114269734B CN202080050268.XA CN202080050268A CN114269734B CN 114269734 B CN114269734 B CN 114269734B CN 202080050268 A CN202080050268 A CN 202080050268A CN 114269734 B CN114269734 B CN 114269734B
Authority
CN
China
Prior art keywords
pharmaceutically acceptable
compounds
formula
acceptable salt
solvate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202080050268.XA
Other languages
English (en)
Chinese (zh)
Other versions
CN114269734A (zh
Inventor
拉朱·莫汉
约翰·努斯
詹森·哈里斯
袁沈东
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Vimaran Biosciences
Original Assignee
Vimaran Biosciences
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vimaran Biosciences filed Critical Vimaran Biosciences
Publication of CN114269734A publication Critical patent/CN114269734A/zh
Application granted granted Critical
Publication of CN114269734B publication Critical patent/CN114269734B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
CN202080050268.XA 2019-05-08 2020-05-07 Jak抑制剂 Active CN114269734B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962845119P 2019-05-08 2019-05-08
US62/845,119 2019-05-08
US201962884588P 2019-08-08 2019-08-08
US62/884,588 2019-08-08
PCT/US2020/031925 WO2020227563A1 (en) 2019-05-08 2020-05-07 Jak inhibitors

Publications (2)

Publication Number Publication Date
CN114269734A CN114269734A (zh) 2022-04-01
CN114269734B true CN114269734B (zh) 2026-03-27

Family

ID=73051620

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202080050268.XA Active CN114269734B (zh) 2019-05-08 2020-05-07 Jak抑制剂

Country Status (13)

Country Link
US (1) US11136329B2 (https=)
EP (1) EP3966209A4 (https=)
JP (1) JP7617030B2 (https=)
KR (1) KR102916168B1 (https=)
CN (1) CN114269734B (https=)
AU (1) AU2020267661A1 (https=)
BR (1) BR112021022380A2 (https=)
CA (1) CA3139277A1 (https=)
IL (1) IL287876A (https=)
MX (1) MX2021013602A (https=)
SG (1) SG11202112362YA (https=)
TW (1) TWI865525B (https=)
WO (1) WO2020227563A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7617030B2 (ja) 2019-05-08 2025-01-17 ビマラン バイオサイエンシーズ，インク． Ｊａｋ阻害剤
KR20220051351A (ko) 2019-08-08 2022-04-26 비말란 바이오사이언스즈, 인크. Jak 억제제
CN114644633B (zh) * 2020-12-18 2026-02-03 北京诺诚健华医药科技有限公司 杂环类jak抑制剂
KR102637915B1 (ko) * 2021-06-25 2024-02-19 한국화학연구원 유비퀴틴 프로테오좀 경로를 통해 비티케이 분해작용을 가지는 신규한 이작용성 헤테로사이클릭 화합물과 이의 용도
WO2023107705A1 (en) 2021-12-10 2023-06-15 Incyte Corporation Bicyclic amines as cdk12 inhibitors

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011134831A1 (en) * 2010-04-30 2011-11-03 Cellzome Limited Pyrazole compounds as jak inhibitors

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA200802685B (en) 2005-09-30 2009-10-28 Vertex Pharma Deazapurines useful as inhibitors of janus kinases
TWI398252B (zh) 2006-05-26 2013-06-11 諾華公司 吡咯并嘧啶化合物及其用途
EP2108019A2 (en) 2007-01-30 2009-10-14 Biogen Idec MA, Inc. 1-h-pyrazolo[3,4b]pyrimidine derivatives and their use as modulators of mitotic kinases
UY31631A1 (es) 2008-02-06 2009-09-30 Nuevos derivados de 7-fenil-7h-pirrolo-[2,3d]-pirimidin-2-il-amino, sales de los mismos, procesos para su preparacion, composiciones farmacéuticas que los comprenden y aplicaciones
US9242987B2 (en) 2009-10-20 2016-01-26 Cellzome Limited Heterocyclyl pyrazolopyrimidine analogues as JAK inhibitors
US8637529B2 (en) 2010-06-11 2014-01-28 AbbYie Inc. Pyrazolo[3,4-d]pyrimidine compounds
WO2012143320A1 (en) * 2011-04-18 2012-10-26 Cellzome Limited (7h-pyrrolo[2,3-d]pyrimidin-2-yl)amine compounds as jak3 inhibitors
WO2013041605A1 (en) * 2011-09-20 2013-03-28 Cellzome Limited Pyrazolo[4,3-c]pyridine derivatives as kinase inhibitors
WO2014001973A1 (en) 2012-06-29 2014-01-03 Pfizer Inc. NOVEL 4-(SUBSTITUTED-AMINO)-7H-PYRROLO[2,3-d]PYRIMIDINES AS LRRK2 INHIBITORS
RU2719477C2 (ru) 2015-06-22 2020-04-17 Оно Фармасьютикал Ко., Лтд. Соединение, ингибирующее brk
CN108864057B (zh) * 2017-05-16 2020-03-31 山东大学 含有4-氨基吡唑结构的jak与hdac双靶点抑制剂及其制备方法和应用
JP7617030B2 (ja) 2019-05-08 2025-01-17 ビマラン バイオサイエンシーズ，インク． Ｊａｋ阻害剤
KR20220051351A (ko) 2019-08-08 2022-04-26 비말란 바이오사이언스즈, 인크. Jak 억제제
BR112022005608A2 (pt) 2019-09-25 2022-09-06 Vimalan Biosciences Inc Inibidores de jak

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011134831A1 (en) * 2010-04-30 2011-11-03 Cellzome Limited Pyrazole compounds as jak inhibitors

Also Published As

Publication number Publication date
EP3966209A4 (en) 2023-01-04
TWI865525B (zh) 2024-12-11
KR102916168B1 (ko) 2026-01-21
BR112021022380A2 (pt) 2022-03-22
JP2022532877A (ja) 2022-07-20
CA3139277A1 (en) 2020-11-12
EP3966209A1 (en) 2022-03-16
MX2021013602A (es) 2022-04-06
TW202108587A (zh) 2021-03-01
JP7617030B2 (ja) 2025-01-17
KR20220052859A (ko) 2022-04-28
IL287876A (en) 2022-01-01
CN114269734A (zh) 2022-04-01
WO2020227563A1 (en) 2020-11-12
US20200369669A1 (en) 2020-11-26
SG11202112362YA (en) 2021-12-30
AU2020267661A1 (en) 2021-12-23
US11136329B2 (en) 2021-10-05

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