CN114259533A - Composition for treating arthralgia and myalgia - Google Patents
Composition for treating arthralgia and myalgia Download PDFInfo
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- CN114259533A CN114259533A CN202210159051.3A CN202210159051A CN114259533A CN 114259533 A CN114259533 A CN 114259533A CN 202210159051 A CN202210159051 A CN 202210159051A CN 114259533 A CN114259533 A CN 114259533A
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Abstract
The invention discloses a composition for treating arthralgia and myalgia, which is prepared from the following raw material medicines in parts by weight: 15-25 parts of dipsacus root, 10-20 parts of dolomite melon peel, 10-20 parts of radix cyathulae, 20-30 parts of hypericum japonicum, 10-20 parts of myrrh, 15-25 parts of frankincense, 15-25 parts of radix angelicae, 10-20 parts of ligusticum wallichii, 15-25 parts of peach kernel, 15-25 parts of eucommia bark, 10-20 parts of green tangerine peel, 5-15 parts of elecampane, 10-20 parts of rhizoma cyperi, 20-30 parts of safflower carthamus, 5-15 parts of ageratum, 15-25 parts of radix clematidis, 10-20 parts of angelica tail, 5-15 parts of dalbergia wood and 20-25 parts of rhizoma drynariae. The external use medicine is used for affected parts of arthroncus, cervical spondylosis, traumatic injury and sprain, lumbar muscle strain and scapulohumeral periarthritis by specific medicine ingredients and dosage proportion, can remarkably relieve pain, enables pain of patients to be relieved or even eliminated, improves life quality of the patients, and has clinical popularization and application values.
Description
Technical Field
The invention particularly relates to a composition for treating arthralgia and myalgia.
Background
The pain of the whole body or parts (such as the spine, joints of the four limbs and the like) caused by natural degeneration of the human body or by trauma, strain and attack of exogenous pathogenic factors belongs to the pain of muscles and bones.
With the advancement of aging society and the change of life style, the common diseases of the old people, such as the muscle and bone pain, also spread among young and middle-aged people, and the prevention and treatment requirements of the muscle and bone pain are rapidly increased. Meanwhile, people still have insufficient understanding on the disease, the treatment is usually biased to local treatment and single disease, the whole system is ignored, and the balance is comprehensively adjusted. The traditional Chinese medicine has numerous, simple, convenient and flexible ways for preventing and treating the disease, has good curative effect and long history, but often has more medicinal flavors, slow response and insignificant curative effect.
Patent CN202011319933 discloses an external medicated wine for traumatic injuries, which has 30 kinds of medicinal ingredients, high cost, long time for administration, and increased mental burden of patients, so it is necessary to develop an external medicated wine for treating arthralgia and myalgia with scientific and reasonable formula and significant curative effect.
Disclosure of Invention
In order to solve the problems, the invention provides a composition for treating arthralgia and myalgia, which is an external preparation prepared from the following raw material medicines in parts by weight:
15-25 parts of dipsacus root, 10-20 parts of dolomite melon peel, 10-20 parts of radix cyathulae, 20-30 parts of hypericum japonicum, 10-20 parts of myrrh, 15-25 parts of frankincense, 15-25 parts of radix angelicae, 10-20 parts of ligusticum wallichii, 15-25 parts of peach kernel, 15-25 parts of eucommia bark, 10-20 parts of green tangerine peel, 5-15 parts of elecampane, 10-20 parts of rhizoma cyperi, 20-30 parts of safflower carthamus, 5-15 parts of ageratum, 15-25 parts of radix clematidis, 10-20 parts of angelica tail, 5-15 parts of dalbergia wood and 20-25 parts of rhizoma drynariae.
Furthermore, the external preparation is prepared from the following raw material medicines in parts by weight:
20 parts of dipsacus root, 15 parts of dolomite melon peel, 15 parts of szechuan lovage rhizome, 25 parts of hypericum japonicum, 15 parts of myrrh, 20 parts of frankincense, 20 parts of angelica dahurica, 15 parts of szechuan lovage rhizome, 20 parts of peach kernel, 20 parts of eucommia bark, 15 parts of green tangerine peel, 10 parts of costustoot, 15 parts of nutgrass galingale rhizome, 25 parts of safflower, 10 parts of ageratum, 20 parts of clematis root, 15 parts of Chinese angelica tail, 10 parts of dalbergia wood and 25 parts of drynaria rhizome.
Furthermore, the external preparation is prepared by taking medicinal powder of raw material medicines, or water or organic solvent extracts of the raw material medicines as active ingredients and adding pharmaceutically acceptable auxiliary materials.
Further, the external preparation is a solution, a spray, an aerosol, a paste, an emulsion; the solution is preferably external medicated wine.
Furthermore, the volume ratio of the total weight of the raw material medicines in the external medicinal liquor to the liquor is 1 Kg: 10-30L.
Furthermore, the wine is rice wine, and the alcoholic strength is 50-60 degrees.
The invention also provides a preparation method of the composition, which comprises the following steps:
1) weighing the raw materials according to the proportion;
2) taking peach kernels, rhizoma cyperi and green tangerine peels, frying, adding the fried peach kernels, rhizoma drynariae and radix notoginseng into the rice wine, soaking for 5-10 days, adding the rest raw materials, continuing to soak for 25-30 days, and filtering to obtain the traditional Chinese medicine.
Further: the stir-frying is to fry the raw materials by slow fire to a depth larger than the color of the raw materials and have slight bulge or burst sound, so that the inherent fragrance of the raw materials is released; the soaking is carried out for 7 days; the soaking is continued for 28 days; the filtration is through a 200 mesh screen.
The invention finally provides the application of the composition in preparing a medicament for treating arthralgia and myalgia.
Further, the medicine is a medicine for treating pain caused by joint swelling, cervical spondylosis, traumatic injury and sprain, lumbar muscle strain and/or scapulohumeral periarthritis.
The radix notoginseng can dissipate blood stasis and stop bleeding, relieve swelling and stop pain, has warm, sweet and slightly bitter smell, is a medicine for treating all blood diseases due to blood system of yangming and jueyin, can stop bleeding, can also remove blood stasis to heal new blood and stop pain, and can be used as a monarch medicine for treating all blood stasis such as traumatic injury, carbuncle swelling, incised wound and the like. Frankincense, myrrh, rhizoma ligustici wallichii and dalbergia wood all can activate blood, promote qi circulation and relieve pain, and the pericarpium citri reticulatae viride, the elecampane and the rhizoma cyperi mainly enter liver channels and are good at promoting qi circulation and relieving swelling to relieve pain, and are used as ministerial drugs together; peach kernel, safflower and Chinese angelica tail descend blood sea to enter foot jueyin meridian to disperse blood and relieve pain, clematis root mainly dispels wind, ventilates five internal organs, can ascend and descend, has good sex, can treat fracture without entering meridian; eucommia bark and dipsacus root have the functions of tonifying liver and kidney, strengthening tendons and bones and continuing fracture, and herba hyperici japonici can dispel stasis and detumescence by entering blood, and can promote diuresis; the angelica dahurica and the agastache rugosus have fragrant smell and are good at dispelling wind, relieving pain, eliminating dampness and eliminating dampness, and the dolichos cucurbita peel is good at eliminating phlegm and dredging collaterals and is used as an adjuvant drug; the compatibility of the whole formula can promote blood circulation to relieve pain, can dredge channels and collaterals to treat fracture, and can dissipate blood stasis and detumescence to treat traumatic injury.
The composition for treating arthralgia and myalgia disclosed by the invention is used for treating arthroncus, cervical spondylosis, traumatic injury and sprain, lumbar muscle strain and scapulohumeral periarthritis affected parts by virtue of specific medicinal ingredients and dosage ratios, can remarkably relieve pain, enables pain of a patient to be relieved or even eliminated, improves life quality of the patient, and has clinical popularization and application values.
Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.
The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.
Detailed Description
The raw materials and equipment used in the embodiment of the invention are known products, and can be obtained by purchasing products sold in the market, wherein the rice wine can also be obtained by fermenting and distilling rice and distiller's yeast.
Example 1 preparation of a composition according to the invention
The formula is as follows: 20 g of dipsacus root, 15 g of white cloud melon peel, 15 g of radix notoginseng, 25 g of hypericum japonicum, 15 g of myrrh, 20 g of frankincense, 20 g of angelica dahurica, 15 g of ligusticum wallichii, 20 g of peach kernel, 20 g of eucommia bark, 15 g of green tangerine peel, 10 g of elecampane, 15 g of rhizoma cyperi, 25 g of safflower, 10 g of ageratum, 20 g of radix clematidis, 15 g of angelica tail, 10 g of dalbergia wood and 25 g of rhizoma drynariae.
The preparation method comprises the following steps:
1) weighing the raw materials according to the proportion;
2) heating semen Persicae, rhizoma Cyperi and pericarpium Citri Reticulatae viride with slow fire (slow fire), parching to deepen color and luster of the raw materials, and slightly swelling or bursting sound to give out inherent fragrance;
3) adding the fried medicinal materials in the step 2), rhizoma drynariae and radix notoginseng into rice wine (the proportion of the rice wine is 10-30 times of the total weight of the prescription, and the weight is L/kg), soaking for 7 days, and taking a container as a tile-made wine jar;
4) after 7 days, adding the other medicinal materials into the step 3), and continuing to soak for 28 days;
5) filtering the supernatant obtained in the step 4) to obtain medicinal liquor with the mesh size of 200 meshes;
wherein the rice wine is prepared by the following method: steaming southern rice in water for 2-4 hr, cooling to 30-40 deg.C, mixing with Guilin koji (the weight ratio of distiller's yeast to rice is 1: 50-70), loading into jar, standing for 18-21 days, diluting with spring water at a mass ratio of 1:2, and distilling to obtain rice wine of 50-60 degree.
Example 2 preparation of the composition of the invention
The formula is as follows: 15 g of himalayan teasel root, 10 g of white cloud melon peel, 10 g of szechuan lovage rhizome, 20 g of hypericum japonicum, 10 g of myrrh, 10 g of frankincense, 15 g of dahurian angelica root, 10 g of szechuan lovage rhizome, 15 g of peach seed, 15 g of eucommia bark, 10 g of green tangerine peel, 5 g of costustoot, 10 g of nutgrass galingale rhizome, 20 g of safflower, 5 g of ageratum, 15 g of clematis root, 10 g of Chinese angelica root, 5 g of dalbergia wood and 25 g of drynaria rhizome.
The preparation method comprises the following steps:
1) weighing the raw materials according to the proportion;
2) heating semen Persicae, rhizoma Cyperi and pericarpium Citri Reticulatae viride with slow fire (slow fire), parching to deepen color and luster of the raw materials, and slightly swelling or bursting sound to give out inherent fragrance;
3) adding the fried medicinal materials in the step 2), rhizoma drynariae and radix notoginseng into rice wine (the proportion of the rice wine is 10-30 times of the total weight of the prescription, and the weight is L/kg), soaking for 7 days, and taking a container as a tile-made wine jar;
4) after 7 days, adding the other medicinal materials into the step 3), and continuing to soak for 28 days;
5) filtering the supernatant obtained in the step 4) to obtain the medicinal liquor with the mesh size of 200 meshes.
Example 3 preparation of the composition of the invention
The formula is as follows: 25 g of himalayan teasel root, 20 g of white cloud melon peel, 20 g of szechuan lovage rhizome, 30 g of hypericum japonicum, 20 g of myrrh, 25 g of frankincense, 25 g of angelica dahurica, 20 g of szechuan lovage rhizome, 25 g of peach seed, 25 g of eucommia bark, 20 g of green tangerine peel, 15 g of costustoot, 20 g of nutgrass galingale rhizome, 30 g of safflower, 15 g of ageratum, 25 g of clematis root, 20 g of Chinese angelica root, 15 g of dalbergia wood and 20 g of drynaria rhizome.
The preparation method comprises the following steps:
1) weighing the raw materials according to the proportion;
2) heating semen Persicae, rhizoma Cyperi and pericarpium Citri Reticulatae viride with slow fire (slow fire), parching to deepen color and luster of the raw materials, and slightly swelling or bursting sound to give out inherent fragrance;
3) adding the fried medicinal materials in the step 2), rhizoma drynariae and radix notoginseng into rice wine (the proportion of the rice wine is 10-30 times of the total weight of the prescription, and the weight is L/kg), soaking for 7 days, and taking a container as a tile-made wine jar;
4) after 7 days, adding the other medicinal materials into the step 3), and continuing to soak for 28 days;
5) filtering the supernatant obtained in the step 4) to obtain the medicinal liquor with the mesh size of 200 meshes.
The advantageous effects of the present invention are described below by way of test examples.
Test example 1 clinical application
1. General data:
118 patients with arthralgia and myalgia of 16-70 years old who were admitted to Batun health institute in 2018, 1 month to 2020, 12 months are selected. Wherein, the number of traumatic sprain cases is 25, 19 joint swelling and pain, 22 lumbar muscle strains, 20 cervical vertebra pain and 32 scapulohumeral periarthritis, and the total number is 118. 65 men and 53 women. 16-30 years old: 33, 31-40 years old: 31, 41-50: 28, 51-70 years old: 26 persons. The patients do not use the medicines for treating the corresponding diseases within 30 days.
2. Evaluation and indexes:
1) method and time selection for evaluating, recording and analyzing validity parameters
Drawing a 10cm transverse line on the paper by using a digital pain scoring method (NRS), and marking 0-10 on the transverse line at intervals of 1 cm; the patient was allowed to record changes in the degree of pain by converting the severity of pain into numbers according to self-sensation and marking on the horizontal line (see table 1 for pain sensation).
TABLE 1 degree of pain
| Number of | Description of pain |
| 0 | Painless |
| 1 | No feeling when not touching. |
| 2 | Pain was felt when touched. |
| 3 | The pain was strong when touched. |
| 4 | There was a slight pain sensation when not touching. |
| 5 | Pain is felt when not touching. |
| 6 | The pain is strong when the patient does not touch the finger. |
| 7 | The pain is continuously serious and serious,it is impossible to fall asleep. |
| 8 | It is painful and difficult to tolerate. |
| 9 | Severe pain, intolerable. |
| 10 | Most painful, not as dead as the body. |
2) Evaluation time: pre-treatment (day 0), treatment day 3, treatment day 5, treatment day 7.
When the subjects who meet the requirements are selected, the therapeutic product is used according to the specified quality method, and the medication tracking condition is recorded according to the following table 2.
TABLE 2 therapeutic effect basis
3) Evaluation criteria
Firstly, the pain disappears and is absent (score 0);
secondly, effect is displayed: pain ranges from heavy (7-10 points) to light (less than 3 points);
③ effective: pain ranges from heavy (7-10 points) to medium (4-6 points), or from medium (4-6 points) to light (less than 3 points);
fourthly, invalidation: there was no improvement in pain compared to pre-treatment.
3. Grouping experiments:
the patients were divided into a control group (57 patients) and a test group (61 patients) by a random double-blind method, wherein the test group uses the medicated wine of the invention in the example 1, and the control group uses a national protection Chinese medicine variety 'Dieda Qili pian' (ZYB 2072015018).
4. The treatment method comprises the following steps:
test groups: a proper amount of medicinal liquor prepared in the embodiment is taken and smeared on an applicable part, the part is slightly massaged by hands until the medicinal liquor is completely absorbed, and the smearing and the massaging are carried out repeatedly for three times. 2-3 times a day;
control group: taking traumatic injury Qili tablet (oral) 1-3 tablets at a time, 3 times a day; it can also be administered with wine.
The service cycle is as follows: and 7 days.
5. Statistical analysis
TABLE 3 effective rate of the medicated wine treatment
Note: effective rate (effective number + apparent number)/total case number x 100%
6. And (4) conclusion:
compared with a control group, the medicinal liquor prepared by the invention has better curative effect on traumatic injury and joint swelling and pain, has higher effective rate on lumbar muscle strain, cervical vertebra pain and scapulohumeral periarthritis than the control group, and has significant difference.
In conclusion, the composition disclosed by the invention is used for treating arthroncus, cervical spondylosis, traumatic injury, sprain, lumbar muscle strain and scapulohumeral periarthritis affected parts by virtue of specific medicinal ingredients and dosage ratios, can remarkably relieve pain in a short time, relieves or even eliminates the pain of a patient, improves the life quality of the patient, and has clinical popularization and application values.
Claims (10)
1. A composition for treating arthralgia and myalgia, which is characterized in that: the external preparation is prepared from the following raw material medicines in parts by weight:
15-25 parts of dipsacus root, 10-20 parts of dolomite melon peel, 10-20 parts of radix cyathulae, 20-30 parts of hypericum japonicum, 10-20 parts of myrrh, 15-25 parts of frankincense, 15-25 parts of radix angelicae, 10-20 parts of ligusticum wallichii, 15-25 parts of peach kernel, 15-25 parts of eucommia bark, 10-20 parts of green tangerine peel, 5-15 parts of elecampane, 10-20 parts of rhizoma cyperi, 20-30 parts of safflower carthamus, 5-15 parts of ageratum, 15-25 parts of radix clematidis, 10-20 parts of angelica tail, 5-15 parts of dalbergia wood and 20-25 parts of rhizoma drynariae.
2. The composition of claim 1, wherein: the external preparation is prepared from the following raw material medicines in parts by weight:
20 parts of dipsacus root, 15 parts of dolomite melon peel, 15 parts of szechuan lovage rhizome, 25 parts of hypericum japonicum, 15 parts of myrrh, 20 parts of frankincense, 20 parts of angelica dahurica, 15 parts of szechuan lovage rhizome, 20 parts of peach kernel, 20 parts of eucommia bark, 15 parts of green tangerine peel, 10 parts of costustoot, 15 parts of nutgrass galingale rhizome, 25 parts of safflower, 10 parts of ageratum, 20 parts of clematis root, 15 parts of Chinese angelica tail, 10 parts of dalbergia wood and 25 parts of drynaria rhizome.
3. The composition of claim 1, wherein: the external preparation is prepared by taking medicinal powder of raw material medicines, or water or organic solvent extracts of the raw material medicines as active ingredients and adding pharmaceutically acceptable auxiliary materials.
4. The composition of claim 3, wherein: the external preparation is a solution, a spray, an aerosol, a paste and an emulsion; the solution is preferably external medicated wine.
5. The composition of claim 3, wherein: the volume ratio of the total weight of the raw material medicines in the external medicinal liquor to the liquor is 1 Kg: 10-30L.
6. The composition of claim 5, wherein: the wine is rice wine, and the alcoholic strength is 50-60 degrees.
7. A method of preparing the composition of any one of claims 1 to 6, wherein: it comprises the following steps:
1) weighing the raw materials according to the proportion;
2) taking peach kernels, rhizoma cyperi and green tangerine peels, frying, adding the fried peach kernels, rhizoma drynariae and radix notoginseng into the rice wine, soaking for 5-10 days, adding the rest raw materials, continuing to soak for 25-30 days, and filtering to obtain the traditional Chinese medicine.
8. The method of claim 7, wherein: the stir-frying is to fry the raw materials by slow fire to a depth larger than the color of the raw materials and have slight bulge or burst sound, so that the inherent fragrance of the raw materials is released; the soaking is carried out for 7 days; the soaking is continued for 28 days; the filtration is through a 200 mesh screen.
9. Use of the composition of any one of claims 1-6 for the preparation of a medicament for the treatment of pain in bones and muscles.
10. Use according to claim 9, characterized in that: the medicine is used for treating pain caused by joint swelling, cervical spondylosis, traumatic injury and sprain, lumbar muscle strain and/or scapulohumeral periarthritis.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210159051.3A CN114259533A (en) | 2022-02-21 | 2022-02-21 | Composition for treating arthralgia and myalgia |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1320429A (en) * | 2000-04-23 | 2001-11-07 | 程金林 | Medical liquor for treating injury |
| CN105267389A (en) * | 2015-11-30 | 2016-01-27 | 刘斌 | External medicine for activating blood circulation and reducing swelling |
| CN105920161A (en) * | 2016-05-30 | 2016-09-07 | 王勤俭 | Powder for eliminating pains of muscles and bones and preparation method thereof |
| CN106728958A (en) * | 2016-12-21 | 2017-05-31 | 四川何天祺医院管理有限公司 | Pharmaceutical composition for treating muscles and bones arthralgia |
| CN110638881A (en) * | 2019-10-18 | 2020-01-03 | 戚春直 | External composition for treating bone diseases and preparation method thereof |
-
2022
- 2022-02-21 CN CN202210159051.3A patent/CN114259533A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1320429A (en) * | 2000-04-23 | 2001-11-07 | 程金林 | Medical liquor for treating injury |
| CN105267389A (en) * | 2015-11-30 | 2016-01-27 | 刘斌 | External medicine for activating blood circulation and reducing swelling |
| CN105920161A (en) * | 2016-05-30 | 2016-09-07 | 王勤俭 | Powder for eliminating pains of muscles and bones and preparation method thereof |
| CN106728958A (en) * | 2016-12-21 | 2017-05-31 | 四川何天祺医院管理有限公司 | Pharmaceutical composition for treating muscles and bones arthralgia |
| CN110638881A (en) * | 2019-10-18 | 2020-01-03 | 戚春直 | External composition for treating bone diseases and preparation method thereof |
Non-Patent Citations (2)
| Title |
|---|
| 曹生华，等: "消肿化瘀合剂的制备与临床应用", 《医药导报》 * |
| 闵云山，等: "消肿止痛合剂的制备与临床应用", 《中国中医药科技》 * |
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