CN114259446A - 一种含滋养复合剂的头皮精华液 - Google Patents
一种含滋养复合剂的头皮精华液 Download PDFInfo
- Publication number
- CN114259446A CN114259446A CN202210092627.9A CN202210092627A CN114259446A CN 114259446 A CN114259446 A CN 114259446A CN 202210092627 A CN202210092627 A CN 202210092627A CN 114259446 A CN114259446 A CN 114259446A
- Authority
- CN
- China
- Prior art keywords
- scalp
- nourishing
- salt
- complexing agent
- zinc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 210000004761 scalp Anatomy 0.000 title claims abstract description 43
- 239000008139 complexing agent Substances 0.000 title claims abstract description 14
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims abstract description 14
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 9
- 239000000284 extract Substances 0.000 claims abstract description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract description 7
- 150000003751 zinc Chemical class 0.000 claims abstract description 7
- 229960002685 biotin Drugs 0.000 claims abstract description 6
- 235000020958 biotin Nutrition 0.000 claims abstract description 6
- 239000011616 biotin Substances 0.000 claims abstract description 6
- OIQJEQLSYJSNDS-UHFFFAOYSA-N piroctone Chemical class CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O OIQJEQLSYJSNDS-UHFFFAOYSA-N 0.000 claims abstract description 6
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims abstract description 5
- SNPLKNRPJHDVJA-ZETCQYMHSA-N D-panthenol Chemical compound OCC(C)(C)[C@@H](O)C(=O)NCCCO SNPLKNRPJHDVJA-ZETCQYMHSA-N 0.000 claims abstract description 5
- 108010058643 Fungal Proteins Proteins 0.000 claims abstract description 5
- 229940101267 panthenol Drugs 0.000 claims abstract description 5
- 235000020957 pantothenol Nutrition 0.000 claims abstract description 5
- 239000011619 pantothenol Substances 0.000 claims abstract description 5
- 229960005323 phenoxyethanol Drugs 0.000 claims abstract description 5
- 229930003799 tocopherol Natural products 0.000 claims abstract description 5
- 229960001295 tocopherol Drugs 0.000 claims abstract description 5
- 239000011732 tocopherol Substances 0.000 claims abstract description 5
- 235000010384 tocopherol Nutrition 0.000 claims abstract description 5
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 5
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 claims abstract description 5
- 239000008367 deionised water Substances 0.000 claims abstract description 4
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 4
- 229940084750 sophora flavescens root extract Drugs 0.000 claims abstract description 4
- 239000000686 essence Substances 0.000 claims description 9
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 6
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims description 5
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims description 5
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 5
- 229940041616 menthol Drugs 0.000 claims description 5
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims description 4
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 4
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims description 4
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 claims description 4
- YPFDHNVEDLHUCE-UHFFFAOYSA-N propane-1,3-diol Chemical compound OCCCO YPFDHNVEDLHUCE-UHFFFAOYSA-N 0.000 claims description 4
- YTKGAYFHUZTLCI-UHFFFAOYSA-N 3-hydroxy-2-iminopyrimidin-4-amine Chemical compound NC1=CC=NC(=N)N1O YTKGAYFHUZTLCI-UHFFFAOYSA-N 0.000 claims description 3
- WHMDKBIGKVEYHS-IYEMJOQQSA-L Zinc gluconate Chemical compound [Zn+2].OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O WHMDKBIGKVEYHS-IYEMJOQQSA-L 0.000 claims description 3
- 229960003966 nicotinamide Drugs 0.000 claims description 3
- 235000005152 nicotinamide Nutrition 0.000 claims description 3
- 239000011570 nicotinamide Substances 0.000 claims description 3
- 239000011670 zinc gluconate Substances 0.000 claims description 3
- 229960000306 zinc gluconate Drugs 0.000 claims description 3
- 235000011478 zinc gluconate Nutrition 0.000 claims description 3
- 229940015975 1,2-hexanediol Drugs 0.000 claims description 2
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 2
- 239000005711 Benzoic acid Substances 0.000 claims description 2
- 239000004354 Hydroxyethyl cellulose Substances 0.000 claims description 2
- 229920000663 Hydroxyethyl cellulose Polymers 0.000 claims description 2
- 229920001214 Polysorbate 60 Polymers 0.000 claims description 2
- 230000002378 acidificating effect Effects 0.000 claims description 2
- 230000002421 anti-septic effect Effects 0.000 claims description 2
- 235000010233 benzoic acid Nutrition 0.000 claims description 2
- 239000004359 castor oil Substances 0.000 claims description 2
- 235000019438 castor oil Nutrition 0.000 claims description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 claims description 2
- 150000002169 ethanolamines Chemical class 0.000 claims description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 claims description 2
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 claims description 2
- 235000019447 hydroxyethyl cellulose Nutrition 0.000 claims description 2
- 229910000403 monosodium phosphate Inorganic materials 0.000 claims description 2
- 235000019799 monosodium phosphate Nutrition 0.000 claims description 2
- AEIJTFQOBWATKX-UHFFFAOYSA-N octane-1,2-diol Chemical compound CCCCCCC(O)CO AEIJTFQOBWATKX-UHFFFAOYSA-N 0.000 claims description 2
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 claims description 2
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 claims description 2
- 229940113124 polysorbate 60 Drugs 0.000 claims description 2
- 239000004302 potassium sorbate Substances 0.000 claims description 2
- 235000010241 potassium sorbate Nutrition 0.000 claims description 2
- 229940069338 potassium sorbate Drugs 0.000 claims description 2
- 239000003755 preservative agent Substances 0.000 claims description 2
- 230000002335 preservative effect Effects 0.000 claims description 2
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 claims description 2
- 235000010234 sodium benzoate Nutrition 0.000 claims description 2
- 239000004299 sodium benzoate Substances 0.000 claims description 2
- AJPJDKMHJJGVTQ-UHFFFAOYSA-M sodium dihydrogen phosphate Chemical compound [Na+].OP(O)([O-])=O AJPJDKMHJJGVTQ-UHFFFAOYSA-M 0.000 claims description 2
- 229940071566 zinc glycinate Drugs 0.000 claims description 2
- 229940043810 zinc pyrithione Drugs 0.000 claims description 2
- OWVLYQRCCIEOPF-QHTZZOMLSA-L zinc;(2s)-5-oxopyrrolidine-2-carboxylate Chemical compound [Zn+2].[O-]C(=O)[C@@H]1CCC(=O)N1.[O-]C(=O)[C@@H]1CCC(=O)N1 OWVLYQRCCIEOPF-QHTZZOMLSA-L 0.000 claims description 2
- PICXIOQBANWBIZ-UHFFFAOYSA-N zinc;1-oxidopyridine-2-thione Chemical compound [Zn+2].[O-]N1C=CC=CC1=S.[O-]N1C=CC=CC1=S PICXIOQBANWBIZ-UHFFFAOYSA-N 0.000 claims description 2
- UOXSXMSTSYWNMH-UHFFFAOYSA-L zinc;2-aminoacetate Chemical compound [Zn+2].NCC([O-])=O.NCC([O-])=O UOXSXMSTSYWNMH-UHFFFAOYSA-L 0.000 claims description 2
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 201000004384 Alopecia Diseases 0.000 abstract description 18
- 231100000360 alopecia Toxicity 0.000 abstract description 6
- 239000003795 chemical substances by application Substances 0.000 abstract description 4
- 150000001875 compounds Chemical class 0.000 abstract description 4
- 239000000126 substance Substances 0.000 abstract description 4
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 abstract description 2
- 230000000694 effects Effects 0.000 description 12
- 208000024963 hair loss Diseases 0.000 description 12
- 210000004209 hair Anatomy 0.000 description 11
- 210000003780 hair follicle Anatomy 0.000 description 11
- 230000003676 hair loss Effects 0.000 description 11
- 241000555676 Malassezia Species 0.000 description 6
- 206010061218 Inflammation Diseases 0.000 description 5
- 230000006872 improvement Effects 0.000 description 5
- 230000004054 inflammatory process Effects 0.000 description 5
- 239000003921 oil Substances 0.000 description 5
- 150000003254 radicals Chemical class 0.000 description 5
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 4
- 230000003078 antioxidant effect Effects 0.000 description 4
- 238000011156 evaluation Methods 0.000 description 4
- 230000002401 inhibitory effect Effects 0.000 description 4
- 150000002632 lipids Chemical class 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 235000015097 nutrients Nutrition 0.000 description 4
- 210000003491 skin Anatomy 0.000 description 4
- 208000003251 Pruritus Diseases 0.000 description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 3
- 230000003110 anti-inflammatory effect Effects 0.000 description 3
- 229940121375 antifungal agent Drugs 0.000 description 3
- 239000003963 antioxidant agent Substances 0.000 description 3
- 235000006708 antioxidants Nutrition 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 229930003935 flavonoid Natural products 0.000 description 3
- 150000002215 flavonoids Chemical class 0.000 description 3
- 235000017173 flavonoids Nutrition 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 3
- 230000003779 hair growth Effects 0.000 description 3
- 230000005764 inhibitory process Effects 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 230000003647 oxidation Effects 0.000 description 3
- 238000007254 oxidation reaction Methods 0.000 description 3
- 230000036542 oxidative stress Effects 0.000 description 3
- 230000001737 promoting effect Effects 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 210000002374 sebum Anatomy 0.000 description 3
- 230000028327 secretion Effects 0.000 description 3
- 239000011701 zinc Substances 0.000 description 3
- 229910052725 zinc Inorganic materials 0.000 description 3
- 208000001840 Dandruff Diseases 0.000 description 2
- 241000196324 Embryophyta Species 0.000 description 2
- NTYJJOPFIAHURM-UHFFFAOYSA-N Histamine Chemical compound NCCC1=CN=CN1 NTYJJOPFIAHURM-UHFFFAOYSA-N 0.000 description 2
- 240000002924 Platycladus orientalis Species 0.000 description 2
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 2
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 2
- 229930003756 Vitamin B7 Natural products 0.000 description 2
- 229930003427 Vitamin E Natural products 0.000 description 2
- 229930013930 alkaloid Natural products 0.000 description 2
- 150000003797 alkaloid derivatives Chemical class 0.000 description 2
- 239000003429 antifungal agent Substances 0.000 description 2
- 230000006907 apoptotic process Effects 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 2
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical class O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 2
- 210000000442 hair follicle cell Anatomy 0.000 description 2
- 230000007803 itching Effects 0.000 description 2
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 150000002978 peroxides Chemical class 0.000 description 2
- 230000002028 premature Effects 0.000 description 2
- 230000035755 proliferation Effects 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 235000005875 quercetin Nutrition 0.000 description 2
- 229960001285 quercetin Drugs 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 238000011160 research Methods 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 235000011912 vitamin B7 Nutrition 0.000 description 2
- 239000011735 vitamin B7 Substances 0.000 description 2
- 235000019165 vitamin E Nutrition 0.000 description 2
- 239000011709 vitamin E Substances 0.000 description 2
- 229940046009 vitamin E Drugs 0.000 description 2
- 238000005406 washing Methods 0.000 description 2
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 description 1
- UFJORDZSBNSRQT-UHFFFAOYSA-N 3-(4-oxo-2-phenylchromen-3-yl)-2-phenylchromen-4-one Chemical compound O1C2=CC=CC=C2C(=O)C(C=2C(C3=CC=CC=C3OC=2C=2C=CC=CC=2)=O)=C1C1=CC=CC=C1 UFJORDZSBNSRQT-UHFFFAOYSA-N 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- 108010066551 Cholestenone 5 alpha-Reductase Proteins 0.000 description 1
- 108090000695 Cytokines Proteins 0.000 description 1
- 102000004127 Cytokines Human genes 0.000 description 1
- 239000004287 Dehydroacetic acid Substances 0.000 description 1
- 206010015150 Erythema Diseases 0.000 description 1
- 241000220485 Fabaceae Species 0.000 description 1
- 206010016654 Fibrosis Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 244000303040 Glycyrrhiza glabra Species 0.000 description 1
- 235000006200 Glycyrrhiza glabra Nutrition 0.000 description 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 description 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 description 1
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 description 1
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 description 1
- 102100025370 Keratin, type II cytoskeletal 71 Human genes 0.000 description 1
- 101710083672 Keratin, type II cytoskeletal 71 Proteins 0.000 description 1
- 102000011782 Keratins Human genes 0.000 description 1
- 108010076876 Keratins Proteins 0.000 description 1
- 241000207923 Lamiaceae Species 0.000 description 1
- 235000006679 Mentha X verticillata Nutrition 0.000 description 1
- 235000002899 Mentha suaveolens Nutrition 0.000 description 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- IKMDFBPHZNJCSN-UHFFFAOYSA-N Myricetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC(O)=C(O)C(O)=C1 IKMDFBPHZNJCSN-UHFFFAOYSA-N 0.000 description 1
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 108010031271 Saccharomyces cerevisiae Proteins Proteins 0.000 description 1
- 206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
- 241000219784 Sophora Species 0.000 description 1
- 241000246044 Sophora flavescens Species 0.000 description 1
- GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 description 1
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 description 1
- 229930003537 Vitamin B3 Natural products 0.000 description 1
- PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 description 1
- 230000001133 acceleration Effects 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000843 anti-fungal effect Effects 0.000 description 1
- 230000001139 anti-pruritic effect Effects 0.000 description 1
- 239000003908 antipruritic agent Substances 0.000 description 1
- 230000001640 apoptogenic effect Effects 0.000 description 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 229960004365 benzoic acid Drugs 0.000 description 1
- 230000000975 bioactive effect Effects 0.000 description 1
- 230000017531 blood circulation Effects 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- SVURIXNDRWRAFU-OGMFBOKVSA-N cedrol Chemical compound C1[C@]23[C@H](C)CC[C@H]3C(C)(C)[C@@H]1[C@@](O)(C)CC2 SVURIXNDRWRAFU-OGMFBOKVSA-N 0.000 description 1
- 229940026455 cedrol Drugs 0.000 description 1
- PCROEXHGMUJCDB-UHFFFAOYSA-N cedrol Natural products CC1CCC2C(C)(C)C3CC(C)(O)CC12C3 PCROEXHGMUJCDB-UHFFFAOYSA-N 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000002596 correlated effect Effects 0.000 description 1
- 230000000875 corresponding effect Effects 0.000 description 1
- 239000013078 crystal Substances 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 235000019258 dehydroacetic acid Nutrition 0.000 description 1
- PGRHXDWITVMQBC-UHFFFAOYSA-N dehydroacetic acid Natural products CC(=O)C1C(=O)OC(C)=CC1=O PGRHXDWITVMQBC-UHFFFAOYSA-N 0.000 description 1
- JEQRBTDTEKWZBW-UHFFFAOYSA-N dehydroacetic acid Chemical compound CC(=O)C1=C(O)OC(C)=CC1=O JEQRBTDTEKWZBW-UHFFFAOYSA-N 0.000 description 1
- 229940061632 dehydroacetic acid Drugs 0.000 description 1
- 235000015872 dietary supplement Nutrition 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000003344 environmental pollutant Substances 0.000 description 1
- 210000005175 epidermal keratinocyte Anatomy 0.000 description 1
- IVTMALDHFAHOGL-UHFFFAOYSA-N eriodictyol 7-O-rutinoside Natural products OC1C(O)C(O)C(C)OC1OCC1C(O)C(O)C(O)C(OC=2C=C3C(C(C(O)=C(O3)C=3C=C(O)C(O)=CC=3)=O)=C(O)C=2)O1 IVTMALDHFAHOGL-UHFFFAOYSA-N 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 239000000469 ethanolic extract Substances 0.000 description 1
- 229940100524 ethylhexylglycerin Drugs 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000004761 fibrosis Effects 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002212 flavone derivatives Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- 239000003102 growth factor Substances 0.000 description 1
- 230000003781 hair follicle cycle Effects 0.000 description 1
- 230000003719 hair strength Effects 0.000 description 1
- 230000003806 hair structure Effects 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 229960001340 histamine Drugs 0.000 description 1
- 239000000413 hydrolysate Substances 0.000 description 1
- 230000003752 improving hair Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- SVURIXNDRWRAFU-UHFFFAOYSA-N juniperanol Natural products C1C23C(C)CCC3C(C)(C)C1C(O)(C)CC2 SVURIXNDRWRAFU-UHFFFAOYSA-N 0.000 description 1
- 210000002510 keratinocyte Anatomy 0.000 description 1
- 229930013686 lignan Natural products 0.000 description 1
- 150000005692 lignans Chemical class 0.000 description 1
- 235000009408 lignans Nutrition 0.000 description 1
- 235000011477 liquorice Nutrition 0.000 description 1
- 150000004668 long chain fatty acids Chemical class 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 235000010755 mineral Nutrition 0.000 description 1
- 229940116852 myricetin Drugs 0.000 description 1
- PCOBUQBNVYZTBU-UHFFFAOYSA-N myricetin Natural products OC1=C(O)C(O)=CC(C=2OC3=CC(O)=C(O)C(O)=C3C(=O)C=2)=C1 PCOBUQBNVYZTBU-UHFFFAOYSA-N 0.000 description 1
- 235000007743 myricetin Nutrition 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 229960003512 nicotinic acid Drugs 0.000 description 1
- 231100000957 no side effect Toxicity 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000004783 oxidative metabolism Effects 0.000 description 1
- 239000001301 oxygen Substances 0.000 description 1
- 229910052760 oxygen Inorganic materials 0.000 description 1
- 230000035515 penetration Effects 0.000 description 1
- 238000005502 peroxidation Methods 0.000 description 1
- 150000007965 phenolic acids Chemical class 0.000 description 1
- 229930015704 phenylpropanoid Natural products 0.000 description 1
- 125000001474 phenylpropanoid group Chemical group 0.000 description 1
- BTSZTGGZJQFALU-UHFFFAOYSA-N piroctone olamine Chemical class NCCO.CC(C)(C)CC(C)CC1=CC(C)=CC(=O)N1O BTSZTGGZJQFALU-UHFFFAOYSA-N 0.000 description 1
- 231100000719 pollutant Toxicity 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 230000003334 potential effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- FDRQPMVGJOQVTL-UHFFFAOYSA-N quercetin rutinoside Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 FDRQPMVGJOQVTL-UHFFFAOYSA-N 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 230000033458 reproduction Effects 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 235000005493 rutin Nutrition 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- ALABRVAAKCSLSC-UHFFFAOYSA-N rutin Natural products CC1OC(OCC2OC(O)C(O)C(O)C2O)C(O)C(O)C1OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5 ALABRVAAKCSLSC-UHFFFAOYSA-N 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 208000008742 seborrheic dermatitis Diseases 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
- 230000000391 smoking effect Effects 0.000 description 1
- 229960003885 sodium benzoate Drugs 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 239000001648 tannin Chemical class 0.000 description 1
- 229920001864 tannin Chemical class 0.000 description 1
- 230000003797 telogen phase Effects 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- 229940117972 triolein Drugs 0.000 description 1
- 150000008130 triterpenoid saponins Chemical class 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 235000019156 vitamin B Nutrition 0.000 description 1
- 239000011720 vitamin B Substances 0.000 description 1
- 235000019160 vitamin B3 Nutrition 0.000 description 1
- 239000011708 vitamin B3 Substances 0.000 description 1
- VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 description 1
- 239000000341 volatile oil Chemical class 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Cosmetics (AREA)
Abstract
本发明属日化领域，具体涉及一种含滋养复合剂的头皮精华液，所述精华液包含滋养复合剂包含0.01％‑10.0％水解酵母蛋白、0.01％‑3.0％泛醇、0.01％‑3.0％生物素、0.01％‑4.0％烟酰胺、0.01％‑3.0％有机锌盐、0.01％‑8.0％侧柏叶提取物、0.01％‑8.0％苦参根提取物、0.01％‑3.0％生育酚、0.01％‑2.0％的1‑羟基‑4‑甲基‑6‑(2,4,4‑三甲基戊基)‑2(1H)‑吡啶酮盐，0.1％‑40％乙醇、0.01％‑1.0％苯氧乙醇，适量去离子水。该滋养复合剂在精华液中应用，有助于减少脱发。
Description
技术领域
本发明属日化领域，具体涉及一种含滋养复合剂的头皮精华液。
背景技术
一些研究表明头发的过早脱落与不健康头皮状态(如头皮屑/脂溢性皮炎)有关，不健康头皮状态造成新生头发在毛囊中不稳固，这些不健康的头皮状态与头皮氧化压力(活性氧/ROS)的产生有相关性。ROS是一类具有高反应活性的自由基。
头发纤维的生长状态与其生长前和生长后的环境有关。在头发生长前，与该状态有关的氧化压力来源包括氧化代谢、吸烟、紫外辐射、微生物的造成的炎症、污染物、刺激源以及头皮脂质的氧化物。Naito的研究发现，甘油三亚油酸酯的过氧化物会造成小鼠毛囊循环周期中休止期的过早出现，而且会诱导毛囊细胞凋亡。同时，过氧化物还会通过上调细胞凋亡的相关基因表达，使人表皮角质形成细胞凋亡。头皮脂质的过氧化与自由基的产生有相关性。马拉色菌是已经证实的头皮氧化压力来源的因素之一。头皮上微生物群落在皮脂腺周围比其他头皮区域丰富，马拉色菌以头皮脂为食物来源。可见，有必要控制头皮马拉色菌数量以及头皮脂分泌程度。
本发明通过抑制马拉色菌过度繁殖，调控头皮脂过度分泌，结合抗氧化植物组合以及滋养成分，缓解头皮氧化压力，改善头皮不健康状态，减少头发的过多脱落。
发明内容
本发明提供一种含滋养复合剂的头皮精华液，配方温和、低刺激，并且具有一定抑制真菌、控油、抗自由基、减少脱发的功效。
一种含滋养复合剂的头皮精华液，除含适量的磷酸二氢钠、1，3－丙二醇、磷酸氢二钠、香精、羟乙基纤维素、甘油外，还含有占精华液重量1.0％－50.0％头皮滋养复合剂、0.05％－3.0％甘草酸二钾、0.05％－4.0％薄荷醇、0.01％－2.0％聚山梨醇酯－60、0.01％－2.0％PEG－40氢化蓖麻油、0.05％－2.0％的防腐体系及余量的去离子水；
所述滋养复合剂为占复合剂重量百分比的下列组分：
(1)0.01％－20.0％水解酵母蛋白；
(2)0.01％－3.0％泛醇；
(3)0.01％－3.0％生物素；
(4)0.01％－4.0％烟酰胺；
(5)0.01％－3.0％有机锌盐；
(6)0.01％－10.0％侧柏叶提取物；
(7)0.01％－10.0％苦参根提取物；
(8)0.01％－3.0％生育酚；
(9)0.01％－2.0％1－羟基－4－甲基－6－(2，4，4－三甲基戊基)－2(1H)－吡啶酮盐；
(10)0.1％－40％乙醇；
(11)0.01％－1.0％苯氧乙醇；
(12)余量去离子水。
本发明有机锌盐选自PCA锌、葡糖酸锌、吡硫鎓锌、甘氨酸锌中的一种。
本发明所述1－羟基－4－甲基－6－(2，4，4－三甲基戊基)－2(1H)－吡啶酮盐优选其乙醇胺盐。
本发明所述防腐体系选自1，2－己二醇、对羟基苯乙酮、苯氧乙醇、乙基己基甘油、苯甲酸、脱氢乙酸、苯甲酸钠、山梨酸钾、辛甘醇两种或两种以上的组合。
本发明所述还可含适量二氨基嘧啶氧化物。
本发明所述头皮精华液的pH值为弱酸性，优选5.5。
本发明的有益效果
本发明优选水解酵母蛋白、泛醇、生物素、烟酰胺、有机锌盐、侧柏叶提取物、苦参根提取物、生育酚、1－羟基－4－甲基－6－(2，4，4－三甲基戊基)－2(1H)－吡啶酮盐等成分为头皮滋养复合剂，包含头皮毛囊营养成分、控油锌、抗真菌剂、抗氧化成分等，多重靶向机制(上调毛囊相关角蛋白基因表达、抑制5a－还原酶活性、抑制马拉色菌、清除自由基、加快局部微循环等)缓解头皮氧化压力和炎症，改善不健康头皮状态。本发明发现含头皮滋养复合剂的精华液可减少脱发数量。
具体实施方式
下面结合实施例对本发明作进一步详述。
先对本发明重要组份选取的特点、注意事项作详细介绍、说明。
水解酵母蛋白是酿酒酵母蛋白的水解产物，是氨基酸、多肽、蛋白质一种或一种以上的组合，可增加角蛋白－71、毛透明蛋白和CD34的表达，优化头发结构和强度，强韧毛囊和头发，减少脱发。
生物素也称为维生素B7或维生素H，是一种水溶性营养物质，生物素的缺乏可能导致脱发，生物素可为毛囊提供营养，潜在协助稳固头发。
泛醇是头皮营养补充剂。
烟酰胺属于B族维生素的一种，别名维生素B3，对皮肤/头皮油滋润作用，同时可潜在促进头皮血液循环，进而促进头发生长，防止脱发。
葡糖酸锌是为白色结晶或粉末，水溶性锌盐，对5a－还原酶具有较强抑制作用，具有控油、缓解头皮炎症等潜在作用，同时为毛囊提供矿物质锌。有研究指出，脱发患者血清中锌离子含量低于健康人群。
PCA锌具有收敛、抗真菌性质，还具有抗氧化和抗炎性能，可通过调节毛囊皮脂腺分泌达到控油效果，另外还具有减少UVA对头皮损伤的功效。
侧柏叶提取物：侧柏叶(PlatycladiCacumen)又名柏叶、扁柏叶、丛柏叶，是侧柏的干燥嫩枝梢及叶。侧柏叶主要化学成分包括黄酮类、挥发油类、鞣质类化合物。侧柏叶中黄酮类化合物主要包括槲皮素、杨梅素、芦丁、槲皮苷、双黄酮等。侧柏叶提取物可抑制5a－还原酶活性、作用于皮脂腺细胞减少皮脂的产生，同时减少脂滴的大小；其成分雪松醇能提升毛囊周围血管流量，增加毛囊细胞营养和氧的供应，有助于减少脱发的产生。
苦参根提取物：苦参(Sophora flavescens Ait)为豆科槐属植物，我国主要产地包括在河北北部、河南西部、山东西南部以及安徽、湖北、贵州等。化学成分主要包括生物碱、黄酮、木脂素、三萜皂苷、酚酸和少量的苯丙素类以及长链脂肪酸类，特别是生物碱类和黄酮类被认为是其主要的生物活性成分。苦参根的乙醇提取物能诱导休止期毛囊过渡到生长期毛囊，并影响毛乳头细胞中IGF－1和KGF等生长因子的水平，还具有一定的抑制5α－还原酶功效。
吡罗克酮乙醇胺盐是抗真菌剂，具有抑制马拉色菌过度繁殖、去屑的性能，另外还具有抗自由基、改善头皮屏障功能的功效。
生育酚又称为维生素E，是一种营养物质，具有优越的抗氧化性能。有研究表明维生素E可减少UV对皮肤的损伤，减少皮肤红斑、水肿的产生，对头皮有一定保护作用。
甘草酸二钾属于天然制品，是以甘草为原料进行提取分离而得甘草酸的衍生物，具有良好的抑菌和抗炎效果，且无副作用。甘草酸二钾可调控皮肤炎症因子的水平，对缓解头皮炎症有一定作用，同时还具有一定抗氧化和促进毛发生长的功效。
薄荷醇又称薄荷脑、薄荷冰，为唇形科植物薄荷的提取物，具有明显的抗炎、镇痛、止痒、局麻、促透、降温等作用，是皮肤科常用的抗炎止痒药物之一。通过多种瘙痒介质和细胞因子的影响发挥其止痒作用，如组胺、4－AP等。还对毛囊角质形成细胞和毛乳头细胞的增殖有促进作用。
毛囊周围纤维化时发根周围胶原蛋白变得僵硬且收缩，推动头发向上移动，导致脱发，二氨基嘧啶氧化物具有潜在缓解该病症的功能。
以下为本发明实施例举例，但本发明保护范围不局限于所示实施例。
实施例1－4，其组分及含量为：
其中各实施例对应的头皮滋养复合剂的组分及含量为：
本发明以志愿者测试的方式进行评测。招募40名符合筛选条件有一定脱发困扰的志愿者，第一组为20名，第二组为20名。第一组使用不含头皮滋养复合剂的BASE配方样品，第二组使用实施例(2)的样品。培训志愿者，统一洗发操作过程，由功效评价人员评分、评估头发掉落数目和志愿者评分结合的方式观察洗发12周后志愿者的脱发的改善情况，0分为无改善，1－3为轻微改善，4－6为较好改善，7－10分很好改善。测试结果如下表，结果表明使用12周后，大部分志愿者脱发状况有改善，同时使用实施例(2)样品后部分志愿者头皮鳞屑状况有所改善。根据功效评价人员评估2组志愿者洗发12周前后头发脱落数目(60次梳发)，第一组前后脱发平均数量分别约为14、15，第二组前后头发脱发平均数量分别约为13、6，说明含滋养复合剂的精华液具有潜在改善脱发的功效。
Claims (7)
1.一种含滋养复合剂的头皮精华液，除含适量的磷酸二氢钠、1,3-丙二醇、磷酸氢二钠、香精、羟乙基纤维素、甘油外，还含有占精华液重量1.0％-50.0％头皮滋养复合剂、0.05％-3.0％甘草酸二钾、0.05％-4.0％薄荷醇、0.01％-2.0％聚山梨醇酯-60、0.01％-2.0％PEG-40氢化蓖麻油、0.05％-2.0％的防腐体系，余量的离子水，
所述的滋养复合剂为占复合剂重量百分比的下列组分：
(1)0.01％-20.0％水解酵母蛋白；
(2)0.01％-3.0％泛醇；
(3)0.01％-3.0％生物素；
(4)0.01％-4.0％烟酰胺；
(5)0.01％-3.0％有机锌盐；
(6)0.01％-10.0％侧柏叶提取物；
(7)0.01％-10.0％苦参根提取物；
(8)0.01％-3.0％生育酚；
(9)0.01％-2.0％1-羟基-4-甲基-6-(2,4,4-三甲基戊基)-2(1H)-吡啶酮盐；
(10)0.1％-40％乙醇；
(11)0.01％-1.0％苯氧乙醇；
(12)余量去离子水。
2.根据权利要求1所述头皮精华液，有机锌盐选自PCA锌、葡糖酸锌、吡硫鎓锌、甘氨酸锌中的一种。
3.根据权利要求2所述头皮精华液，1-羟基-4-甲基-6-(2,4,4-三甲基戊基)-2(1H)-吡啶酮盐优选其乙醇胺盐。
4.根据权利要求3所述的头皮精华液，防腐体系选自1,2-己二醇、对羟基苯乙酮、苯氧乙醇、乙基己基甘油、苯甲酸、脱乙酸、苯甲酸钠、山梨酸钾、辛甘醇其中的两种或两种以上的组合。
5.根据权利要求4所述的头皮精华液，还含有适量二氨基嘧啶氧化物。
6.根据权利要求2所述的头皮精华液，pH值为弱酸性。
7.根据权利要求6所述的头皮精华液，pH值为优选5.5。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210092627.9A CN114259446A (zh) | 2022-01-26 | 2022-01-26 | 一种含滋养复合剂的头皮精华液 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210092627.9A CN114259446A (zh) | 2022-01-26 | 2022-01-26 | 一种含滋养复合剂的头皮精华液 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN114259446A true CN114259446A (zh) | 2022-04-01 |
Family
ID=80833480
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210092627.9A Pending CN114259446A (zh) | 2022-01-26 | 2022-01-26 | 一种含滋养复合剂的头皮精华液 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114259446A (zh) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115192505A (zh) * | 2022-07-25 | 2022-10-18 | 浙江浩迈科技有限公司 | 一种防脱混合液及其制备方法 |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103442681A (zh) * | 2012-03-19 | 2013-12-11 | 吴桂谦 | 一种含有吡啶酮盐和尿囊素的头发去屑组合物 |
| CN106491482A (zh) * | 2016-10-08 | 2017-03-15 | 拉芳家化股份有限公司 | 一种含抗老化及防脱复合剂的护发组合物 |
| CN108938485A (zh) * | 2018-08-06 | 2018-12-07 | 上海优萃生物科技有限公司 | 一种防脱发的生发液及其制备方法 |
| CN109260038A (zh) * | 2018-11-01 | 2019-01-25 | 南京新生医疗科技有限公司 | 一种生发、固发、护发营养液及其制备工艺 |
| CN110236975A (zh) * | 2019-07-04 | 2019-09-17 | 杭州诗昀生物科技有限公司 | 一种头皮护理洗发水 |
| CN111012693A (zh) * | 2019-12-23 | 2020-04-17 | 广州市科能化妆品科研有限公司 | 一种多效头皮护理组合物、制备方法及其应用 |
| CN112516049A (zh) * | 2020-12-18 | 2021-03-19 | 广州隆翔化妆品有限公司 | 一种竹醋去屑头皮精华液及其制备方法 |
-
2022
- 2022-01-26 CN CN202210092627.9A patent/CN114259446A/zh active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103442681A (zh) * | 2012-03-19 | 2013-12-11 | 吴桂谦 | 一种含有吡啶酮盐和尿囊素的头发去屑组合物 |
| CN106491482A (zh) * | 2016-10-08 | 2017-03-15 | 拉芳家化股份有限公司 | 一种含抗老化及防脱复合剂的护发组合物 |
| CN108938485A (zh) * | 2018-08-06 | 2018-12-07 | 上海优萃生物科技有限公司 | 一种防脱发的生发液及其制备方法 |
| CN109260038A (zh) * | 2018-11-01 | 2019-01-25 | 南京新生医疗科技有限公司 | 一种生发、固发、护发营养液及其制备工艺 |
| CN110236975A (zh) * | 2019-07-04 | 2019-09-17 | 杭州诗昀生物科技有限公司 | 一种头皮护理洗发水 |
| CN111012693A (zh) * | 2019-12-23 | 2020-04-17 | 广州市科能化妆品科研有限公司 | 一种多效头皮护理组合物、制备方法及其应用 |
| CN112516049A (zh) * | 2020-12-18 | 2021-03-19 | 广州隆翔化妆品有限公司 | 一种竹醋去屑头皮精华液及其制备方法 |
Non-Patent Citations (1)
| Title |
|---|
| 程丑夫, vol. 1, 湖南科学技术出版社, pages: 176 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115192505A (zh) * | 2022-07-25 | 2022-10-18 | 浙江浩迈科技有限公司 | 一种防脱混合液及其制备方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| KR101504908B1 (ko) | 모시풀(Boehmeria nivea) 추출물을 유효성분으로 함유하는 피부장벽강화용 조성물 | |
| KR101928797B1 (ko) | 컴파운드 ｋ를 함유하는 피부 외용제 조성물 | |
| JP2020529420A (ja) | ネフェリウム・ラパセウム（Ｎｅｐｈｅｌｉｕｍ ｌａｐｐａｃｅｕｍ）抽出物の新規な美容的使用 | |
| KR20140126892A (ko) | 진세노사이드 Rg3를 함유하는 피부 외용제 조성물 | |
| KR102063686B1 (ko) | 콩뿌리 추출물을 함유하는 피부 외용제 조성물 | |
| KR101397160B1 (ko) | 선복화, 백미 및 영릉향을 이용한 두피 자극완화용 화장료 조성물 | |
| CN114259446A (zh) | 一种含滋养复合剂的头皮精华液 | |
| KR20190137328A (ko) | 병아리꽃나무 추출물을 포함하는 항노화용 피부외용제 조성물 | |
| KR101896563B1 (ko) | 제주광나무 추출물을 함유하는 보습용 화장료 조성물 | |
| KR101418366B1 (ko) | 봉독 및 프로폴리스를 함유하는 여드름 예방 또는 치료용 조성물 | |
| JP4906179B2 (ja) | 皮膚外用剤 | |
| KR101934976B1 (ko) | 고욤나무 잎 및 울금 추출물의 혼합물을 유효성분으로 함유하는 피부장벽강화용 조성물 | |
| KR101445642B1 (ko) | 배롱나무 추출물을 유효성분으로 함유하는 화장료 조성물 | |
| KR102475898B1 (ko) | 그라비올라 항균 추출물을 함유하는 화장료 조성물 및 그 제조방법 | |
| KR101086227B1 (ko) | 나도개감채 추출물을 유효성분으로 함유하는 화장료 조성물 | |
| KR20140126891A (ko) | 진세노사이드 Rf를 함유하는 피부 외용제 조성물 | |
| JPH03112912A (ja) | 化粧料組成物 | |
| CN112675101A (zh) | 一种美白祛斑组合物、美白祛斑霜及其制备方法 | |
| KR101909533B1 (ko) | 진세노사이드 ｆ１을 함유하는 피부 외용제 조성물 | |
| KR20110078536A (ko) | 조팝나무 추출물을 유효성분으로 함유하는 화장료 조성물 | |
| KR20170051077A (ko) | 맥문동 추출물 및 천연 추출물을 유효성분으로 함유하는 조성물 | |
| KR20140131027A (ko) | 진세노사이드 Rh4를 함유하는 피부 외용제 조성물 | |
| KR102223447B1 (ko) | 두피 및 모발용 화장료 조성물 | |
| KR20130026678A (ko) | 참지네고사리 추출물을 유효성분으로 함유하는 화장료 조성물 및 이를 이용하는 화장방법 | |
| KR20130034720A (ko) | 아왜나무 추출물을 유효성분으로 함유하는 화장료 조성물 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination |