CN1142314C - Osteo-implanted body of porous titanium with biological coating and its manufacture method - Google Patents
Osteo-implanted body of porous titanium with biological coating and its manufacture method Download PDFInfo
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- CN1142314C CN1142314C CNB991237080A CN99123708A CN1142314C CN 1142314 C CN1142314 C CN 1142314C CN B991237080 A CNB991237080 A CN B991237080A CN 99123708 A CN99123708 A CN 99123708A CN 1142314 C CN1142314 C CN 1142314C
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Abstract
The present invention relates to a method for preparing a bone implant with a porous titanium biologic coating, which is characterized in that the bonding strength between the bone implant with a porous titanium biologic coating using titanium alloy or stainless steel as a base material and the base material is from 25MPa to 45MPa. The preparing method comprises: the mixed powder of titanium and aluminum or the mixed powder of titanium alloy and aluminum is sprayed on the surface of the base material by oxy-acetylene flames or plasma under the protection of argon; the sprayed base material is soaked in 30 to 40% of alkaline liquor, is cleaned by water, and is protected by the argon or is dried by vacuum for 2 hours to 10 hours. The present invention has the advantages of high strength, stable performance, simple operation of the preparing method and low cost. The present invention is used for manufacturing various orthotic materials of artificial joints with porous titanium biologic coatings, vertebral arch nails, intramedullary nails, bone fracture plates, screws, tooth roots, etc. Good bone combination can be formed between the bone implant and bone tissue so that the aim of permanent or semi-permanent biologic internal fixation is achieved.
Description
Technical field
The present invention relates to the manufacturing of osteo-implanted body of porous titanium with biological coating.
Background technology
Titanium or titanium alloy is with its good biocompatibility, and erosion resistance and light weight, intensity is high and the near characteristics such as Young's modulus of bone photo, as the excellent material of artificial bone, joint, tooth root, blood vessel, orthopedic implant.For bone implant being reached permanent and the semipermanent biological fixation, implant surfaces is made vesicular or coralliform surface with titanium or titanium alloy, reach growing into and the fusion of regenerating of osseous tissue and tissue, thereby make bone implant not take place to become flexible and come off.In view of the foregoing, porous and coralliform titanium with biological coating are developed, Japanese Patent JP62, and 174,302 reports bond the back under 1350 degree Celsius with titanium alloy powder and titanium alloy base material, vacuum sintering 5 hours, thus form the porous titanium alloy top coat.U.S. Pat 4,650,109 report that also the method for making porous surface is to adopt binding agent to be heated to the manufacturing of β transformation temperature.JP04,141,163 also are reported in the bone implant that 950 degree sintering Celsius were made the porous surface coating in 4 hours.Above-mentioned manufacture method all needs to give and is adhered to earlier on the base material, often is affected with implant base material bonding strength, and will operates cost height, complicated operation under the high temperature high vacuum condition.
Summary of the invention
The manufacture method that the purpose of this invention is to provide a kind of osteo-implanted body of porous titanium with biological coating, can overcome above-mentioned shortcoming, titanium or titanium alloy porous of the present invention and coralliform coating and base material are metallurgical binding, intensity improves, stable performance, suitable osseous tissue is grown into, and manufacturing operation is simple, cost is low, can make the porous bone implant of joint prosthesis, artificial bone, Steel Plate For Fixation Of Fracture, intramedullary nail, vertebral arch nail, tooth root, screw or other form.
The present invention is to be that base material and porous titanium or titanium alloy coating constitute with titanium, titanium alloy or stainless steel, and said coating is the porous titanium with biological coating that commercial pure titanium, titanium alloy form.
Manufacture method of the present invention comprises the steps:
With the substrate metal material of implant through clean, after the sandblast; with oxygen-acetylene flame sprayed coating or plasma spraying; make protection gas with argon gas; titanium-aluminium powder mix or titanium alloy-aluminium powder mix are sprayed at the surface of titanium valve bottoming; also can feel secure without titanium valve; directly be sprayed at the surface that titanium or titanium alloy are base material, when stainless steel surface sprays, will feel secure with 300 order left and right sides titanium valves.The granularity of titanium valve or titanium alloy powder is the 80-280 order, and the granularity of aluminium powder is the 80-200 order, is preferably the 100-180 order.The weight ratio of titanium, aluminium powder is 2.7-6.5: 1, be preferably 3.1: 1.
The said metal base of the present invention can be commercial pure titanium TA3, TA4, titanium alloy (Ti-6Al-4V), stainless steel 316L, 317L.The aperture of coating can be from 50 microns-450 microns, porosity 30-45% (volume ratio), with base material be metallurgical binding, bonding strength can reach 25Mpa-45Mpa.
The said titanium of the present invention-aluminium powder mix coating thickness is 200 microns-800 microns.After the spraying, be soaked in the alkaline solution (sodium hydroxide of 30-40% or potassium hydroxide), reacted 5-24 hour down, be preferably in more than 10 hours in 25-65 degree Celsius.Reaction back is fully cleaned, and under 400-600 degree Celsius argon shield or vacuum-drying 2-10 hour then, obtains the coralloid titanium with biological coating bone implant of porous at last.
The present invention can be used for making multiple orthotic materials such as the joint prosthesis, artificial bone, vertebral arch nail, intramedullary nail, Steel Plate For Fixation Of Fracture, screw, tooth root of porous titanium with biological coating, the suitable osseous tissue of the artificial implant of manufacturing of the present invention is grown into, can form good synostosis with osseous tissue, thereby reach permanent or the biological internal fixing of semipermanent.Intensity height of the present invention, stable performance, manufacture method is simple to operate, and cost is low.
Outstanding substantial characteristics of the present invention and positively effect can be embodied from following embodiment, but they are not that the present invention is imposed any restrictions.
Embodiment
Embodiment 1.
Get 120 order commercially pure titanium valves, 81.5 grams, 150 order pure aluminium powder, 26 gram thorough mixing clean the oil removing in excusing from death ripple cleaning machine of the pure titanium material of TA3 Steel Plate For Fixation Of Fracture, carry out surface sand-blasting with 40# diamond spar sand and handle.With the oxy-acetylene flame spraying titanium-aluminium powder mix (using the U.S. to produce the 5P spray gun) of argon shield, thickness is 400 microns.Compound concentration is 40% sodium hydroxide solution; the Steel Plate For Fixation Of Fracture that will spray titanium aluminium powder mix under 25 degree Celsius immerses; be warming up to 60 degree Celsius gradually; reacted 24 hours; take out fully and clean; and behind surface dressing, being incubated 2 hours down with argon shield in 600 degree Celsius, slow cooling promptly obtains the titanium material Steel Plate For Fixation Of Fracture of porous titanium with biological coating to room temperature.
Embodiment 2.
Batching is with embodiment 1, and base material is a 316L stainless steel Steel Plate For Fixation Of Fracture, and through oil removing, sandblasting, the oxygen under argon shield--acetylene flame sprays 300 purpose titanium valves, and thickness 40--80 micron then sprays titanium-aluminium powder mix.All the other operations obtain the stainless steel Steel Plate For Fixation Of Fracture of porous titanium with biological coating with embodiment 1.
Embodiment 3.
Batching for TA4 titanium system intramedullary nail, through oil removing, sandblasting, directly sprays titanium aluminium powder mix with embodiment 1. base materials, and all the other processes obtain the titanium material intramedullary nail of porous titanium with biological coating with embodiment 1.
Claims (7)
1. the manufacture method of an osteo-implanted body of porous titanium with biological coating comprises that with titanium, titanium alloy or stainless steel be base material and POROUS TITANIUM that is coated in substrate surface or titanium alloy coating formation, and the aperture of said coating is 50 microns-450 microns, porosity 30-45%; Said coating and base material bonding strength are 25Mpa-45Mpa, it is characterized in that it comprises the steps:
(1) titanium of bone implant, titanium alloy or stainless steel substrate metallic substance are cleaned, after the sandblast, under argon shield, with oxy-acetylene flame or plasma titanium-aluminium powder mix or titanium alloy-aluminium powder mix are sprayed at substrate surface, the weight ratio of titanium and aluminium powder is 2.7-6.5: 1;
(2) under 25-65 degree temperature Celsius, be soaked in the alkaline solution, reacted 5-24 hour;
(3) water cleans, and then under the temperature of 400-600 degree Celsius, under argon shield or the vacuum dry 2-10 hour, slowly the cold room temperature that causes obtained the coralloid titanium with biological coating bone implant of porous at last.
2. according to the manufacture method of the said osteo-implanted body of porous titanium with biological coating of claim 1, feel secure with the spraying of 300 order titanium valves earlier when it is characterized in that the spraying of said stainless steel substrate surface.
3. according to the manufacture method of the said osteo-implanted body of porous titanium with biological coating of claim 1, the granularity that it is characterized in that said titanium valve or titanium alloy powder is the 80-280 order; The granularity of aluminium powder is the 80-200 order.
4. according to the manufacture method of the said osteo-implanted body of porous titanium with biological coating of claim 1, the weight ratio that it is characterized in that said titanium and aluminium powder is 3.1: 1.
5. according to the manufacture method of the said osteo-implanted body of porous titanium with biological coating of claim 3, the granularity that it is characterized in that said aluminium powder is the 100-180 order.
6. according to the manufacture method of the said osteo-implanted body of porous titanium with biological coating of claim 1, it is characterized in that said alkaline solution is sodium hydroxide or the potassium hydroxide solution of 30-40%.
7. the manufacture method of the said osteo-implanted body of porous titanium with biological coating of claim 1 is characterized in that said coating is the porous titanium with biological coating of commercial pure titanium or titanium alloy T i-6AL-4V.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB991237080A CN1142314C (en) | 1999-11-16 | 1999-11-16 | Osteo-implanted body of porous titanium with biological coating and its manufacture method |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB991237080A CN1142314C (en) | 1999-11-16 | 1999-11-16 | Osteo-implanted body of porous titanium with biological coating and its manufacture method |
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| Publication Number | Publication Date |
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| CN1250820A CN1250820A (en) | 2000-04-19 |
| CN1142314C true CN1142314C (en) | 2004-03-17 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB991237080A Expired - Fee Related CN1142314C (en) | 1999-11-16 | 1999-11-16 | Osteo-implanted body of porous titanium with biological coating and its manufacture method |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100493624C (en) * | 2006-04-07 | 2009-06-03 | 中国科学院金属研究所 | Implant body of porous titanium for biological and medical use, and preparation method |
| CN101195916B (en) * | 2006-12-05 | 2012-05-23 | 林德股份公司 | Method for producing porous surfaces on metal components |
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| CN100574726C (en) * | 2008-04-17 | 2009-12-30 | 上海交通大学 | Partial gradient pore space structure artificial arthrosis prosthesis and preparation method thereof |
| CN101961507A (en) * | 2010-10-26 | 2011-02-02 | 四川材料与工艺研究所 | Medicinal implant and preparation method thereof |
| CN102580169A (en) * | 2012-02-28 | 2012-07-18 | 淮阴工学院 | Coating for improving bioactivity of stainless-steel bone lamella and bone nail |
| CN102580154A (en) * | 2012-02-28 | 2012-07-18 | 淮阴工学院 | Antifriction and toughening metal/ceramic bionic multilayer-film artificial joint |
| CN107385429B (en) * | 2017-07-11 | 2019-12-31 | 西安建筑科技大学 | Medical titanium alloy surface porous titanium coating and preparation method thereof |
| CN107519531B (en) * | 2017-08-24 | 2021-03-30 | 张阳 | Titanium alloy bone implant with biological coating structure and preparation method thereof |
| CN108393493B (en) * | 2018-01-31 | 2023-09-15 | 山东建筑大学 | Preparation method of high-strength degradable nano medical porous titanium-based composite material |
| CN108385054A (en) * | 2018-04-17 | 2018-08-10 | 江西科技师范大学 | A kind of conductive network configuration coating and preparation method |
| CN112111738B (en) * | 2020-07-22 | 2022-07-22 | 上海微创医疗器械（集团）有限公司 | Medical implant device, preparation method thereof and preparation method of intravascular stent |
| CN112662983B (en) * | 2020-12-04 | 2022-11-29 | 西部宝德科技股份有限公司 | Preparation method of porous layer on surface of titanium and titanium alloy |
-
1999
- 1999-11-16 CN CNB991237080A patent/CN1142314C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100493624C (en) * | 2006-04-07 | 2009-06-03 | 中国科学院金属研究所 | Implant body of porous titanium for biological and medical use, and preparation method |
| CN101195916B (en) * | 2006-12-05 | 2012-05-23 | 林德股份公司 | Method for producing porous surfaces on metal components |
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| Publication number | Publication date |
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| CN1250820A (en) | 2000-04-19 |
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