CN100574726C - Partial gradient pore space structure artificial arthrosis prosthesis and preparation method thereof - Google Patents
Partial gradient pore space structure artificial arthrosis prosthesis and preparation method thereof Download PDFInfo
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- CN100574726C CN100574726C CN200810036140.9A CN200810036140A CN100574726C CN 100574726 C CN100574726 C CN 100574726C CN 200810036140 A CN200810036140 A CN 200810036140A CN 100574726 C CN100574726 C CN 100574726C
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- titanium
- gradient pore
- arthrosis
- prosthesis
- space structure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2/30767—Special external or bone-contacting surface, e.g. coating for improving bone ingrowth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/30—Joints
- A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
Abstract
A kind of partial gradient pore space structure artificial arthrosis prosthesis and preparation method thereof belongs to biomedical engineering field.Prosthese of the present invention comprises: prosthese handle, gradient pore structured body, gradient pore structured body is welded on the default position of prosthese handle, gradient pore structured body comprises: metallic titanium plate, the first Titanium ball, the second Titanium ball, the 3rd Titanium ball, three Titanium ball sizes are ascending, and with different levels sintering is on metallic titanium plate.The present invention earlier by sintering process with globular metallic powder by different level sintering on metallic titanium plate, obtain gradient pore structured body, be welded on the predetermined position of articular prosthesis then.The present invention both can be so that the prosthese handle have been avoided high-temperature heat treatment process, keep good high-strength mechanical properties, and can obtain suitable gradient pore structured, for growing into of cell, tissue provides the space, promote the ankylose of freshman bone tissue and host bone, realize the biological fixation of prosthese, can be applicable to the reparation of joint injury clinically.
Description
Technical field
What the present invention relates to is the orthopaedics implants prosthese in a kind of biomedical engineering technology field and preparation method thereof, is specifically related to a kind of partial gradient pore space structure artificial arthrosis prosthesis and preparation method thereof.
Background technology
Artificial joint replacement is a kind of common operation method for the treatment of the joint injury that causes because of wound or disease clinically, and clinical application effect is good.The mechanics of artificial joint and biology performance are the key elements that influences its clinical repair joint injury effect.Articular prosthesis by metal material manufacturings such as rustless steel, titanium and alloys thereof all has the good mechanical performance usually, behind the implant into body, can satisfy stressed requirement in patient's daily behavior active procedure.Though titanium and alloy thereof have good anti-corrosion and biocompatibility.But still there are serious defective in the various titaniums that use clinically and the prosthese of alloy material thereof aspect biology performance at present, as: the bulk metal prosthese can not be organized good ankylose with the human body soft or hard.In order to overcome this problem, loose structure is being attempted being made in the part of prosthese, so that for growing into of human body cell, tissue provides the space, promotes the ankylose of cambium and prosthese, realizes biological fixation.
Plasma spraying technology is the method that present a kind of part in prosthetic surface of generally adopting prepares loose structure.This technology is to adopt plasma arc as thermal source, and metal material is heated to fusion or semi-molten state, and to spray to the method that forms the surface layer of adhesion-tight through pretreated surface of the work at a high speed, belongs to the high-temperature heat treatment technology.In the process of prosthetic surface spray metal powder, because action of high temperature, the mechanical property of prosthese itself will be affected, and causes the reduction of prosthese mechanical property, ruptures easily after replacing human body.Therefore, under the prerequisite that does not reduce the mechanical property of prosthese own, make up the partial pore structure of prosthetic surface,, promote the ankylose of cambium and prosthese, have important engineering meaning and clinical value for growing into of cell, tissue provides the space.
Find by prior art documents, application number: 87101194.8, publication number: CN1033559 title: " making technique of artificial joint with porous surface layer ", this technology is disclosed to be a kind of with a kind of manufacturing process of spheroidal particle direct sintering on the prosthese handle, prosthese handle in this technical process will be subjected to action of high temperature equally, thereby influences the mechanical property of prosthese handle itself; The loose structure artificial joint prosthesis (www.zimmer.com) of the Zimmer company exploitation that the whole world is famous, be a kind of Local Porous structure artificial joint prosthesis that adopts the plasma spraying technology preparation, the mechanical property of prosthese handle can be subjected to pyritous influence and decrease.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, a kind of partial gradient pore space structure artificial arthrosis prosthesis and preparation method thereof is provided, make it overcome the deficiency of the mechanical property of damage prosthese in the existing preparation artificial joint prosthesis porous surface configuration process own, for growing into of human body cell, tissue provides the space, promote the ankylose of cambium and articular prosthesis, realize the biological fixation of prosthese.
The present invention is achieved by the following technical solutions:
Partial gradient pore space structure artificial arthrosis prosthesis of the present invention comprises: prosthese handle, gradient pore structured body, gradient pore structured body are welded on the default position of prosthese handle, form the artificial joint prosthesis of partial gradient pore structure.
Described gradient pore structured body comprises: metallic titanium plate, the first Titanium ball, the second Titanium ball, the 3rd Titanium ball.The first Titanium ball, the second Titanium ball, the 3rd Titanium ball size are ascending, and with different levels sintering is on metallic titanium plate, and wherein the first Titanium ball of size minimum contacts with metallic titanium plate.
The described first Titanium ball, its diameter are 100-200 μ m.
The described second Titanium ball, its diameter are 200-300 μ m.
Described the 3rd Titanium ball, its diameter are 300-500 μ m.
Described gradient pore structured body, its porosity is at 20-50%.
Described metallic titanium plate is titanium and alloy sheets thereof.
Described Titanium ball is spherical titanium and alloy powder thereof.
In the above-mentioned prosthese, the effect of prosthese handle is that carrying is stressed, and the effect of gradient pore structured body is that the growth for cell, tissue provides the space, realizes the biological fixation of prosthese.
The preparation method of partial gradient pore space structure artificial arthrosis prosthesis of the present invention comprises the steps:
The first step, on a titanium and alloy sheets thereof, lay the spherical titanium and the alloy powder thereof of three kinds of diameters successively, wherein the spherical titanium of minimum diameter and alloy powder thereof directly are tiled on a titanium and the alloy sheets thereof, spread 1～2 layer, then, on the spherical titanium of minimum diameter and alloy powder layer thereof, lay the titanium and the alloy powder thereof of intermediate diameters, spread 1～2 layer, at last at the titanium of intermediate diameters and the spherical titanium and the alloy powder thereof of alloy powder layer upper berth one deck diameter maximum thereof;
The spherical titanium and the alloy powder thereof of described minimum diameter, its diameter are 100～200 μ m.
The titanium of described intermediate diameters and alloy powder thereof, its diameter are 200-300 μ m.
The spherical titanium and the alloy powder thereof of described diameter maximum, its diameter are 300～500 μ m.
Described titanium and alloy sheets thereof, its long 30～50mm, wide 20～30mm, thickness 3～5mm.
Second step, above-mentioned titanium and the alloy sheets thereof that is covered with spherical titanium and alloy powder thereof inserted vacuum sintering furnace, carry out sintering, charging temperature is a room temperature, furnace temperature is warming up to 1200-1400 ℃, exerts pressure to titanium that is covered with spherical powder and alloy sheets thereof in the sintering process, insulation, pressurize, furnace temperature stove be cooled to room temperature, obtain a kind of titanium and alloy sheets thereof of surface graded pore structure thereafter;
Described sintering furnace, its vacuum are 1 * 10
-3Pa.
Described intensification, its speed are 5 ℃/min-10 ℃/min.
Described exerting pressure, its pressure limit are 2Mpa-5Mpa.
Described insulation, pressurize, its time is 1h-2h.
The 3rd step, utilize laser welding technology, the titanium of above-mentioned surface graded pore structure and alloy sheets thereof are welded on precalculated position on the articular prosthesis, form and have high-strength mechanical properties and local surface graded loose structure artificial joint prosthesis.
The artificial joint prosthesis surface local loose structure of plasma spraying technology preparation though can provide the space for the growth of cell, tissue, is realized the biological fixation of prosthese.But,, reduced the original high-strength mechanical properties of prosthese because action of high temperature and the high-speed impact of metal-powder under fusion or semi-molten state make the mechanical property of articular prosthesis itself be affected.The partial gradient pore space structure artificial arthrosis prosthesis of the present invention's preparation not only has good pore structure; can provide the space for the growth of cell, tissue; realize the biological fixation of prosthese, but also well protected the original high-strength mechanical properties of prosthese itself.
The present invention has taked the manufacturing process of multiple step format, high-sintering process and assembly technology are separated, earlier by high-sintering process with the stratified sintering of the globular metallic powder of different size on metallic titanium plate, formation has gradient pore structured parts, then, adopt laser welding technology, under the prerequisite of not damaging the mechanical property of prosthese own, prepared gradient pore structured parts are welded on the predetermined position of articular prosthesis, formation has high-strength mechanical properties and local gradient pore structured artificial joint prosthesis, can be applicable to the reparation of joint injury clinically.
Description of drawings
Fig. 1 is a structural representation of the present invention
Fig. 2 is gradient pore structured body sketch map
The specific embodiment
Below in conjunction with accompanying drawing embodiments of the invention are elaborated: following examples are being to implement under the prerequisite with the technical solution of the present invention; provided detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.
As shown in Figure 1, the prosthese in following examples comprises: prosthese handle 1, gradient pore structured body 2, gradient pore structured body 2 is welded on the default position of prosthese handle 1, forms the artificial joint prosthesis of partial gradient pore structure.
As shown in Figure 2, the gradient pore structured body 2 in following examples comprises: metallic titanium plate 3, be of a size of 100-200 μ m the first Titanium ball 4, be of a size of 200-300 μ m the second Titanium ball 5, be of a size of the 3rd Titanium ball 6 of 300-500 μ m.Three Titanium ball 4,5,6 with different levels sintering form gradient pore structured body 2 on metallic titanium plate 3, its porosity is at 20-50%.
Below provide the embodiment of described partial gradient pore space structure artificial arthrosis prosthesis preparation method in detail.
The sized spherical titanium powder that at first with diameter is 100 μ m is tiled on the titanium plate of a block length 30mm, wide 20mm, thickness 3mm, spreads 3 layers, and then, the sized spherical titanium powder that to repave 3 layers of diameter be 200 μ m is spread the sized spherical titanium powder that one deck diameter is 300 μ m at last; The above-mentioned titanium plate that is covered with sized spherical titanium powder is inserted vacuum sintering furnace, carry out high temperature sintering, the vacuum of sintering furnace is 1 * 10
-3Pa, charging temperature are room temperature, and furnace temperature is risen to 1200 ℃, programming rate is 5 ℃/min, applies the pressure of 5MPa in the sintering process to the titanium plate that is covered with spherical powder, insulation, pressurize 2h, furnace temperature stove be cooled to room temperature, obtain a kind of titanium plate of surface graded pore structure thereafter; Utilize laser welding technology, the titanium plate of above-mentioned surface graded pore structure is welded on precalculated position on the artificial joint prosthesis, form partial gradient pore space structure artificial arthrosis prosthesis.The porosity (value of calculation) of embodiment 1 correspondence is 32%.
The sized spherical titanium powder that at first with diameter is 200 μ m is tiled on the titanium plate of a block length 50mm, wide 40mm, thickness 5mm, spreads 1 layer, and then, the sized spherical titanium powder that to repave 1 layer of diameter be 300 μ m is spread the sized spherical titanium powder that one deck diameter is 500 μ m at last; The above-mentioned titanium plate that is covered with sized spherical titanium powder is inserted vacuum sintering furnace, carry out high temperature sintering, the vacuum of sintering furnace is 1 * 10
-3Pa, charging temperature are room temperature, and furnace temperature is risen to 1400 ℃, programming rate is 10 ℃/min, applies the pressure of 2MPa in the sintering process to the titanium plate that is covered with spherical powder, insulation, pressurize 1h, furnace temperature stove be cooled to room temperature, obtain a kind of titanium plate of surface graded pore structure thereafter; Utilize laser welding technology, the titanium plate of above-mentioned surface graded pore structure is welded on precalculated position on the artificial joint prosthesis, form partial gradient pore space structure artificial arthrosis prosthesis.The porosity (value of calculation) of embodiment 2 correspondences is 23%.
Embodiment 3
The sized spherical titanium powder that at first with diameter is 150 μ m is tiled on the titanium plate of a block length 40mm, wide 30mm, thickness 4mm, spreads 2 layers, and then, the sized spherical titanium powder that to repave 2 layers of diameter be 250 μ m is spread the sized spherical titanium powder that one deck diameter is 400 μ m at last; The above-mentioned titanium plate that is covered with sized spherical titanium powder is inserted vacuum sintering furnace, carry out high temperature sintering, the vacuum of sintering furnace is 1 * 10
-3Pa, charging temperature are room temperature, and furnace temperature is risen to 1300 ℃, programming rate is 7.5 ℃/min, applies the pressure of 1.5MPa in the sintering process to the titanium plate that is covered with spherical powder, insulation, pressurize 1.5h, furnace temperature stove be cooled to room temperature, obtain a kind of titanium plate of surface graded pore structure thereafter; Utilize laser welding technology, the titanium plate of above-mentioned surface graded pore structure is welded on precalculated position on the artificial joint prosthesis, form partial gradient pore space structure artificial arthrosis prosthesis.The porosity (value of calculation) of embodiment 3 correspondences is 28%.
Claims (10)
1, a kind of partial gradient pore space structure artificial arthrosis prosthesis is characterized in that, comprising: prosthese handle, gradient pore structured body, gradient pore structured body are welded on the default position of prosthese handle, wherein:
Described gradient pore structured body comprises: metallic titanium plate, the first Titanium ball, the second Titanium ball, the 3rd Titanium ball, the first Titanium ball, the second Titanium ball, the 3rd Titanium ball size are ascending, and with different levels sintering is on metallic titanium plate, and wherein the first Titanium ball of size minimum contacts with metallic titanium plate.
2, partial gradient pore space structure artificial arthrosis prosthesis according to claim 1 is characterized in that, the described first Titanium ball, its diameter are 100-200 μ m.
3, partial gradient pore space structure artificial arthrosis prosthesis according to claim 1 is characterized in that, the described second Titanium ball, its diameter are 200-300 μ m.
4, partial gradient pore space structure artificial arthrosis prosthesis according to claim 1 is characterized in that, described the 3rd Titanium ball, its diameter are 300-500 μ m.
5, partial gradient pore space structure artificial arthrosis prosthesis according to claim 1 is characterized in that, described gradient pore structured body, and its porosity is at 20-50%.
6, a kind of preparation method of partial gradient pore space structure artificial arthrosis prosthesis according to claim 1 is characterized in that, comprises the steps:
The first step, on a titanium and alloy sheets thereof, lay the spherical titanium and the alloy powder thereof of three kinds of diameters successively, wherein the spherical titanium of minimum diameter and alloy powder thereof directly are tiled on a titanium and the alloy sheets thereof, spread 1～2 layer, then, on the spherical titanium of minimum diameter and alloy powder layer thereof, lay the titanium and the alloy powder thereof of intermediate diameters, spread 1～2 layer, at last at the titanium of intermediate diameters and the spherical titanium and the alloy powder thereof of alloy powder layer upper berth one deck diameter maximum thereof;
Second step, above-mentioned titanium and the alloy sheets thereof that is covered with spherical titanium and alloy powder thereof inserted vacuum sintering furnace, carry out sintering, charging temperature is a room temperature, furnace temperature is warming up to 1200-1400 ℃, exerts pressure to titanium that is covered with spherical powder and alloy sheets thereof in the sintering process, insulation, pressurize, furnace temperature be cooled to room temperature, obtain a kind of titanium and alloy sheets thereof of surface graded pore structure thereafter;
The 3rd step, utilize laser welding technology, the titanium of above-mentioned surface graded pore structure and alloy sheets thereof are welded on precalculated position on the articular prosthesis, form partial gradient pore space structure artificial arthrosis prosthesis.
7, the preparation method of partial gradient pore space structure artificial arthrosis prosthesis according to claim 6 is characterized in that, in the first step, the spherical titanium and the alloy powder thereof of described minimum diameter, its diameter are 100～200 μ m; The titanium of described intermediate diameters and alloy powder thereof, its diameter are 200-300 μ m; The spherical titanium and the alloy powder thereof of described diameter maximum, its diameter are 300～500 μ m.
8, according to the preparation method of claim 6 or 7 described partial gradient pore space structure artificial arthrosis prosthesis, it is characterized in that, in the first step, described titanium and alloy sheets thereof, its long 30～50mm, wide 20～30mm, thickness 3～5mm.
9, the preparation method of partial gradient pore space structure artificial arthrosis prosthesis according to claim 6 is characterized in that, in second step, and described sintering furnace, its vacuum is 1 * 10
-3Pa; Described intensification, its speed are 5 ℃/min-10 ℃/min.
10, according to the preparation method of claim 6 or 9 described partial gradient pore space structure artificial arthrosis prosthesis, it is characterized in that, in second step, described exerting pressure, its pressure limit is 2Mpa-5Mpa; Described insulation, pressurize, its time is 1h-2h.
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