CN114225243A - Nerve regulation and control system for regulating blood sugar - Google Patents
Nerve regulation and control system for regulating blood sugar Download PDFInfo
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- CN114225243A CN114225243A CN202111531378.0A CN202111531378A CN114225243A CN 114225243 A CN114225243 A CN 114225243A CN 202111531378 A CN202111531378 A CN 202111531378A CN 114225243 A CN114225243 A CN 114225243A
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- A61B5/14532—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue for measuring glucose, e.g. by tissue impedance measurement
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Abstract
The application discloses a neural regulation and control system for blood sugar regulation, and relates to the technical field of neural regulation and control. The cervical blood glucose monitoring system comprises a control module, an infrared imaging positioning module, an ultrasonic stimulation module and a blood glucose monitoring module, wherein the infrared imaging positioning module, the ultrasonic stimulation module and the blood glucose monitoring module are connected with the control module; the control module is configured to: receiving a blood vessel development signal sent by an infrared imaging positioning module in real time and a blood glucose concentration signal sent by a blood glucose monitoring module in real time, positioning the vagus nerve according to the accompanying relation between the cervical blood vessel and the vagus nerve, and adjusting the focus position of an ultrasonic stimulation module according to the position of the vagus nerve; adjusting the ultrasound parameters of the ultrasound stimulation module. The application is used for interfering the vagus nerve of the neck by utilizing ultrasonic waves so as to realize the regulation and control of blood sugar.
Description
Technical Field
The application relates to the technical field of nerve regulation, in particular to a nerve regulation system for regulating blood sugar.
Background
Diabetes mellitus is a common metabolic disease, and blood sugar cannot be effectively controlled mainly due to insufficient insulin secretion and insulin resistance. The medicine treatment is the main treatment mode at present, and with the deep research on diabetes, the pathogenesis of the diabetes is found to have close relation with the nervous system, and particularly, the important relation between the peripheral vagus nerve and blood sugar is proved, so that the intervention of the vagus nerve through the nerve regulation technology has important significance for treating the diabetes.
Neuromodulation techniques have been widely used in the treatment and study of neurological diseases. Ultrasonic stimulation is a novel nerve regulation technology except electricity, magnetism and light. Ultrasound stimulation has been extensively studied in central nervous system disorders. Recent progress has found that ultrasonic stimulation also has a regulating effect on the peripheral nervous system. At present, ultrasound has sufficient experimental research on the effect of vagus nerve, but because human neck tissues are complex in deconstruction, the vagus nerve has various relationships with other tissues and is difficult to accurately position, and because an ultrasound nerve regulation system aiming at the vagus nerve is lacked, a great problem is brought to the clinical application of ultrasound nerve regulation. In the prior art, peripheral nerves of a mouse are regulated and controlled by using ultrasound, the blood sugar level of the mouse can be effectively regulated by stimulating a liver by using ultrasound, and the blood sugar can also be regulated by regulating vagus nerves of an abdominal cavity and spleen by using ultrasound, so that a better effect is obtained, but the ganglion in the abdominal cavity is difficult to locate, and gastrointestinal tract organs contain a large amount of gas, so that the ultrasonic action is easily interfered.
Meanwhile, the nerve regulation and control technology carries out continuous stimulation according to a preset treatment scheme at present, and long-term stimulation also brings potential threats to life safety such as heart rate and unstable blood pressure to a human body, so that a set of vagus nerve ultrasonic regulation and control system which can monitor changes of blood sugar and vital signs of a patient in real time and can carry out treatment according to actual conditions of the patient is needed.
Disclosure of Invention
The application provides a neural regulation and control system for blood sugar regulation utilizes the vagus nerve of companion's relation location vagus nerve of neck blood vessel and vagus nerve, has solved the inaccurate drawback of vagus nerve location, realizes the regulation and control of blood sugar simultaneously.
In order to achieve the above object, the present application provides a neuromodulation system for blood glucose regulation, comprising a control module, and an infrared imaging and positioning module, an ultrasonic stimulation module and a blood glucose monitoring module connected to the control module, wherein: the infrared imaging positioning module is used for developing blood vessels of the neck, the ultrasonic stimulation module is used for sending ultrasonic waves to the vagus nerve of the neck, and the blood glucose monitoring module is used for monitoring the blood glucose concentration in real time;
the control module is configured to: receiving a blood vessel development signal sent by an infrared imaging positioning module in real time and a blood glucose concentration signal sent by a blood glucose monitoring module in real time, positioning the vagus nerve according to the accompanying relation between the cervical blood vessel and the vagus nerve, and adjusting the focus position of an ultrasonic stimulation module according to the position of the vagus nerve; adjusting the ultrasound parameters of the ultrasound stimulation module.
Further, control module is including bluetooth receiver, central controller and the display screen of connecting, wherein:
the Bluetooth receiver is used for receiving a positioning signal sent by the infrared imaging positioning module in real time and a blood glucose concentration signal sent by the blood glucose monitoring module in real time;
the central controller is configured to: positioning the vagus nerve according to the concomitance relationship between the cervical blood vessel and the vagus nerve, adjusting the focus position of the ultrasonic stimulation module according to the position of the vagus nerve, and adjusting the ultrasonic parameters of the ultrasonic stimulation module according to the touch operation of the user;
the display screen is used for displaying the blood vessels and vagus nerves of the neck, blood sugar concentration, ultrasonic parameters and receiving touch operation of a user.
Further, the ultrasonic parameters of the ultrasonic stimulation module are adjusted according to the dynamic change of the blood glucose concentration.
Furthermore, the infrared imaging positioning module comprises an infrared excitation light source and a focusing lens, and the infrared excitation light source is used for emitting infrared light to develop blood vessels.
Furthermore, the infrared excitation light source is an LED bulb, and the frequency bands of the infrared excitation light source are 850nm and 940 nm.
Further, the ultrasonic stimulation module comprises an ultrasonic transducer and a parameter controller, and the parameter controller is used for receiving the ultrasonic parameter regulation and control instruction sent by the control module and controlling the intensity of the ultrasonic wave according to the ultrasonic parameter regulation and control instruction.
Further, the ultrasonic transducer is a focused ultrasonic transducer.
Further, the blood glucose monitoring module comprises a laser emitting device and a receiving device.
Further, still include power, supersound power amplifier and be used for with the integrative bluetooth chip of receiving and dispatching of control model intercommunication, in the integrative bluetooth chip power embedding power of receiving and dispatching, the power setting is on supersound power amplifier.
Furthermore, the control module further comprises a watch disk-shaped shell and a wrist strap for fixing the shell on the hand, two ends of the wrist strap are respectively fixed at two end parts of the shell, the Bluetooth receiver, the central controller and the display screen are all arranged in the shell, and a battery is arranged on one side of the back surface of the shell.
Compared with the prior art, the application has the following beneficial effects:
(1) this application utilizes the vagus nerve of ultrasonic intervention neck and then regulation and control blood sugar, and governing system possesses and does not have the wound, and is safe, accurate, satisfy the demand of individualized operation and treatment. Due to the non-invasive nature of the ultrasonic stimulation, the ultrasonic energy is directly applied to the neck skin, and adverse reactions related to the operation are greatly reduced. Through infrared laser imaging, can pinpoint in the target location, noninvasive, fast get discernment neck blood vessel sign, guide supersound to the regulation and control of nerve blood vessel.
(2) The vagus nerve is positioned by utilizing the accompanying relation between the neck blood vessel and the vagus nerve, the neck blood vessel can be developed and positioned and the focus position of the ultrasonic transducer can be adjusted by the infrared imager before ultrasonic stimulation, and the accuracy and the convenience of ultrasonic stimulation are improved.
(3) The ultrasonic stimulation device can receive treatment of other parts while performing ultrasonic stimulation, and the examinee can move properly while performing ultrasonic stimulation, so that the comfort of the examinee is greatly improved. Meanwhile, the ultrasonic diagnosis and treatment device also comprises a blood sugar monitoring module to observe the dynamic change of blood sugar, so that the ultrasonic regulation and control are more flexible, effective and safe.
Drawings
In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only some embodiments of the present application, and for those skilled in the art, other drawings can be obtained according to the drawings without creative efforts.
FIG. 1 is a schematic diagram of a regulatory system of the present application;
FIG. 2 is an assembled schematic view of a Bluetooth chip, power supply and ultrasonic power amplifier;
FIG. 3 is a schematic diagram of a control module of the present application;
FIG. 4 is a schematic view of the attachment of the housing and wristband.
In the figure, 1-infrared imaging positioning module, 2-blood sugar monitoring module, 3-ultrasonic stimulation module, 4-transceiver integrated Bluetooth chip, 5-power supply, 6-ultrasonic power amplifier, 7-Bluetooth receiver, 8-display screen, 9-wrist strap, 10-central controller, 11-battery and 12-shell.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
In the description of the present application, it is to be noted that, unless otherwise explicitly specified or limited, the terms "mounted," "connected," and "connected" are to be construed broadly, e.g., as meaning either a fixed connection, a removable connection, or an integral connection; the specific meaning of the above terms in the present application can be understood in a specific case by those of ordinary skill in the art.
In the process of transmitting ultrasonic waves, due to the absorption, reflection or scattering of a medium and other actions, the sound energy of the ultrasonic waves is converted into kinetic energy to generate an action force on the medium transmitted by the ultrasonic waves, the action force is called ultrasonic radiation force, ultrasonic nerve regulation is realized by acting the ultrasonic radiation force on nerve tissues to enable microstructures of the nerve tissues and neurons to react, and the change of the state of synapses of the neurons can cause the activation of ion channels on cell membranes of certain secretory cells and then secrete related proteins, and macroscopically shows that the ultrasonic waves have the nerve regulation effect on life bodies after passing through the nerve tissues.
The application provides a neural regulation system for blood sugar regulation, which utilizes the relative superficial of the cervical vagus nerve and the parallel relationship between the cervical blood vessel and the vagus nerve to accurately position the vagus nerve.
Referring to fig. 1, the system comprises a control module, and an infrared imaging positioning module 1, an ultrasonic stimulation module 3 and a blood glucose monitoring module 2 which are connected with the control module. Specifically, the infrared imaging positioning module 1, the blood glucose monitoring module 2 and the ultrasonic stimulation module 3 are sequentially sleeved from outside to inside. The infrared imaging positioning module 1 can make the blood vessel of the neck develop, the ultrasonic stimulation module 3 is used for sending ultrasonic waves to the vagus nerve of the neck, and the blood sugar monitoring module 2 is used for monitoring the blood sugar concentration in real time. The control module is configured to: receiving a blood vessel development signal sent by the infrared imaging positioning module 1 in real time and a blood glucose concentration signal sent by the blood glucose monitoring module 2 in real time, positioning the vagus nerve according to the concomitance relationship between the cervical blood vessel and the vagus nerve, and adjusting the focus position of the ultrasonic stimulation module 3 according to the position of the vagus nerve; the ultrasound parameters of the ultrasound stimulation module 3 are adjusted.
This application develops the neck blood vessel through infrared imaging orientation module 1, and develop signal transmission to control module with the blood vessel, control module just can be according to the blood vessel and develop signal and neck blood vessel and vagus company's relation location vagus nerve, and then adjusts the 3 focus positions of supersound stimulation module, the supersound stimulation module 3 after focusing sends the ultrasonic wave to the vagus nerve of neck, intervene neck vagus and control blood sugar metabolism activity, just can reach the purpose of the relevant metabolic disease of treatment. And during ultrasonic stimulation, the dynamic change of the blood glucose concentration is monitored by the blood glucose monitoring module 2, and the ultrasonic stimulation is adjusted in time.
The infrared imaging positioning module 1 comprises an infrared excitation light source and a focusing lens, wherein the infrared excitation light source is used for emitting infrared light, and the infrared light reaches the deep part of the skin after being emitted, so that blood vessels can be developed. The infrared imaging positioning module 1 receives feedback signals while emitting infrared light to the skin and deep part, and transmits the feedback signals to the control module to complete positioning. The infrared imaging positioning module 1 can adopt an LED bulb as a light source, and also can select other light sources capable of generating infrared rays according to experimental conditions. Infrared light sources in the 850nm and 940nm bands are preferred, but are not limited to other infrared bands.
The ultrasonic stimulation module 3 comprises an ultrasonic transducer and an ultrasonic parameter controller, and the ultrasonic transducer can convert electric energy into sound energy by using a piezoelectric material. The parameter controller is used for receiving the ultrasonic parameter regulation and control instruction sent by the control module and controlling the intensity of the ultrasonic wave according to the ultrasonic parameter regulation and control instruction. The ultrasonic transducer contains a focusing pressure ceramic chip which can generate ultrasonic waves and focus the ultrasonic waves on the vagus nerve of the neck together with an infrared imaging module. It should be noted that, according to the research and treatment needs, the ultrasonic transducers with different frequencies, different focusing effects, different output energies and different focal spot sizes and focal lengths can be selected, and the ultrasonic transducer with the fundamental frequency of 200kHz to 4MHz is preferably used, but not limited to the above parameters. On the ultrasound transducer material, a magnetically compatible material is preferred, but is not limited to the choice of other materials. Preferably, a focused ultrasound transducer is used and operates at a low intensity energy output, but is not limited to the use of a focused ultrasound transducer, and other types of ultrasound transducers may be used.
The blood sugar monitoring module 2 comprises a laser emitting device and a receiving device, the laser emitting device generates near-infrared laser to reach the skin, glucose in the tissue gap can generate specific absorption spectrum to the near infrared laser, and the blood sugar concentration is judged by detecting the reflection intensity. The near infrared monitoring module utilizes infrared light as a monitoring index, preferably adopts parameters in two frequency bands of near infrared short wave (780-1100 nm) and near infrared long wave (1100-2526 nm) excited by laser, but is not limited to selecting light sources of other sources and other parameters.
Referring to fig. 3, the control module includes a bluetooth receiver 7, a central controller 10 and a display screen 8, which are connected, and the bluetooth receiver 7 is configured to receive a blood vessel development signal sent by the infrared imaging and positioning module 1 in real time and a blood glucose concentration signal sent by the blood glucose monitoring module 2 in real time. The central controller 10 is configured to position the vagus nerve according to the blood vessel visualization signal, adjust the focal position of the ultrasound stimulation module 3 according to the position of the vagus nerve, and adjust the ultrasound parameters of the ultrasound stimulation module 3, wherein when adjusting the parameters, the control module can automatically adjust the dynamic change of the blood glucose concentration to the corresponding parameters, and also adjust the ultrasound parameters of the ultrasound stimulation module 3 according to a touch operation command of a user on a touch screen; the display screen 8 is used for displaying the blood vessels and vagus nerves of the neck, blood glucose concentration, ultrasonic parameters, and receiving touch operations of the user.
Referring to fig. 4, the control module further includes a watch-disc-shaped housing 12, the bluetooth receiver 8, the central controller 10 and the display screen 11 are all packaged inside the housing 12, the wrist bands 9 are fixed at two ends of the housing 12, and the battery 11 is arranged at one side of the back of the housing 12, so that a structure similar to a smart watch is formed, and the wearing is facilitated. The Bluetooth receiver 7 is a Bluetooth transceiving integrated chip, and the display screen 8 is a liquid crystal panel for visually observing the state of each index. The housing 12 may be made of any material with good tissue compatibility, such as resin, plastic, and peek, but is not limited to metal. The battery 11 is preferably a rechargeable lithium battery, but is not limited to the use of other battery types.
Referring to fig. 2, the system further includes a power supply 5, an ultrasonic power amplifier 6 and a transceiver bluetooth chip 4 for communicating with the control model, the transceiver bluetooth chip 4 is embedded in the power supply 5, the power supply 5 includes a rechargeable lithium battery for supplying power to the device, the power supply 5 is disposed on the ultrasonic power amplifier 6, and the ultrasonic power amplifier 6 can provide larger power for the ultrasonic transducer.
This application has non-invasiveness and ease for use, can be more quick, accurate discernment neck blood vessel and nerve, and the regulation and control effect of guide supersound to nerve, simultaneously, this application can be through the blood sugar monitoring module monitoring implement to the blood sugar change of object, and the supersound of timely adjustment is amazing, can effectively impel the application of supersound thorn vagus nerve regulation and control blood sugar.
The above is only an embodiment of the present application, but the scope of the present application is not limited thereto, and any changes or substitutions within the technical scope of the present disclosure should be covered by the scope of the present application. Therefore, the protection scope of the present application shall be subject to the protection scope of the claims.
Claims (10)
1. The utility model provides a nerve regulation and control system for blood sugar regulation which characterized in that, includes control module and the infrared imaging orientation module, supersound stimulation module and the blood sugar monitoring module of being connected with control module, wherein: the infrared imaging positioning module is used for developing blood vessels of the neck, the ultrasonic stimulation module is used for sending ultrasonic waves to the vagus nerve of the neck, and the blood glucose monitoring module is used for monitoring the blood glucose concentration in real time;
the control module is configured to: receiving a blood vessel development signal sent by an infrared imaging positioning module in real time and a blood glucose concentration signal sent by a blood glucose monitoring module in real time, positioning the vagus nerve according to the accompanying relation between the cervical blood vessel and the vagus nerve, and adjusting the focus position of an ultrasonic stimulation module according to the position of the vagus nerve; adjusting the ultrasound parameters of the ultrasound stimulation module.
2. The neuromodulation system for glucose regulation as in claim 1, wherein the control module comprises a bluetooth receiver, a central controller, and a display screen connected thereto, wherein:
the Bluetooth receiver is used for receiving a blood vessel development signal sent by the infrared imaging positioning module in real time and a blood glucose concentration signal sent by the blood glucose monitoring module in real time;
the central controller is configured to: positioning the vagus nerve according to the concomitance relationship between the cervical blood vessel and the vagus nerve, adjusting the focus position of the ultrasonic stimulation module according to the position of the vagus nerve, and adjusting the ultrasonic parameters of the ultrasonic stimulation module according to the touch operation of the user;
the display screen is used for displaying the blood vessels and vagus nerves of the neck, blood sugar concentration, ultrasonic parameters and receiving touch operation of a user.
3. The neuromodulation system for glucose regulation as in claim 1, wherein the ultrasound parameters of the ultrasound stimulation module are adjusted in response to dynamic changes in glucose concentration.
4. The neuromodulation system for regulating blood glucose as in claim 1, wherein the infrared imaging positioning module comprises an infrared excitation light source and a focusing lens, the infrared excitation light source is used for emitting infrared light to visualize blood vessels.
5. The neuromodulation system as in claim 4, wherein the IR excitation light source is an LED bulb, and the IR excitation light source has a frequency range of 850nm and 940 nm.
6. The neuromodulation system as in claim 2 or 3, wherein the ultrasound stimulation module comprises an ultrasound transducer and a parameter controller, and the parameter controller is configured to receive the ultrasound parameter control command sent by the control module and control the intensity of the ultrasound wave according to the ultrasound parameter control command.
7. The neuromodulation system for glucose regulation as in claim 6, wherein the ultrasound transducer is a focused ultrasound transducer.
8. The neuromodulation system for glucose regulation of claim 1, wherein the glucose monitoring module includes a laser emitting device and a receiving device.
9. The neuromodulation system for glucose regulation of claim 1, further comprising a power supply, an ultrasonic power amplifier, and a bluetooth transceiver-integrated chip for communicating with the control model, the bluetooth transceiver-integrated chip power supply being embedded in the power supply, the power supply being disposed on the ultrasonic power amplifier.
10. The neuromodulation system for glucose regulation of claim 2, wherein the control module further comprises a watch-shaped housing and a wrist strap for fixing the housing to the hand, the two ends of the wrist strap are respectively fixed at the two ends of the housing, the bluetooth receiver, the central controller and the display screen are all arranged inside the housing, and the battery is arranged on one side of the back surface of the housing.
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CN202111531378.0A CN114225243A (en) | 2021-12-15 | 2021-12-15 | Nerve regulation and control system for regulating blood sugar |
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CN115153528A (en) * | 2022-07-29 | 2022-10-11 | 燕山大学 | System and method for noninvasive stimulation and detection of whole brain network connection |
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CN115153528A (en) * | 2022-07-29 | 2022-10-11 | 燕山大学 | System and method for noninvasive stimulation and detection of whole brain network connection |
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