CN114209870A - Medical dressing containing high-molecular water-absorbent resin and preparation method thereof - Google Patents

Medical dressing containing high-molecular water-absorbent resin and preparation method thereof Download PDF

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Publication number
CN114209870A
CN114209870A CN202111571199.XA CN202111571199A CN114209870A CN 114209870 A CN114209870 A CN 114209870A CN 202111571199 A CN202111571199 A CN 202111571199A CN 114209870 A CN114209870 A CN 114209870A
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China
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layer
absorbent resin
molecular water
medical dressing
dressing containing
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徐会军
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Shandong Wanrong Biotechnology Co ltd
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Shandong Wanrong Biotechnology Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/24—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/28—Polysaccharides or their derivatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/32—Proteins, polypeptides; Degradation products or derivatives thereof, e.g. albumin, collagen, fibrin, gelatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/44—Medicaments
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/42—Use of materials characterised by their function or physical properties
    • A61L15/46—Deodorants or malodour counteractants, e.g. to inhibit the formation of ammonia or bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors

Abstract

The invention provides a medical dressing containing high-molecular water-absorbent resin and a preparation method thereof, and relates to the technical field of medical materials. The water-absorbing resin comprises a moisture-absorbing layer, an adhesive layer and a medicine-placing layer, wherein the moisture-absorbing layer is used for being attached to skin, the adhesive layer is used for adhering adhesive cloth, and the medicine-placing layer is positioned between the moisture-absorbing layer and the adhesive layer; the water absorbing layer comprises high molecular water absorbing resin and vaseline, the medicine releasing layer comprises an antibacterial agent, recombinant human epidermal growth factor and sodium hyaluronate, and the bonding layer is polyurethane; the dressing not only can effectively absorb moisture, blood, tissue fluid and the like at the wound to avoid wound infection, but also can not prevent the medicine in the medicine placing layer from entering the wound; the invention also provides a preparation method of the medical dressing containing the high-molecular water-absorbent resin, which is simple and convenient to operate, can effectively reduce the operation difficulty of operators, can increase the preparation efficiency and is convenient to popularize.

Description

Medical dressing containing high-molecular water-absorbent resin and preparation method thereof
Technical Field
The invention relates to the technical field of medical materials, in particular to a medical dressing containing high-molecular water-absorbent resin and a preparation method thereof.
Background
The medical dressing comprises natural gauze, synthetic fiber dressing, polymeric film dressing, foaming polymeric dressing, hydrocolloid dressing, alginate dressing and the like. Medical dressings are wound covering articles used to cover sores, wounds, or other damaged medical materials. With the intensive research on the pathophysiology of the wound healing process, people understand the wound healing process more and more deeply, thereby leading to the continuous improvement and development of medical wound dressings. Compared with the early days, the novel dressing for wound care has revolutionized, and a plurality of medical dressings with different properties can be selected by clinical care personnel. The medical dressing not only can powerfully and rapidly absorb wound surface exudate of a wound, but also is simple and convenient in production and processing process, and convenient to popularize and produce in batches.
However, the current medical dressing can not take care of both water retention and repair of damaged tissues of human body, when water retention is emphasized, the pore diameter of the water absorption layer is small, so that the medicine seepage speed of the medicine on the medicine feeding layer is slow, the wound healing speed is slow, the healing effect is poor, when the pore diameter of the water absorption layer is large, the seepage speed of the medicine feeding layer is fast, but the water absorption effect is poor, the medicine is easy to flow into the leaked blood or tissue fluid, and the medicine cannot effectively take effect.
Therefore, at present, a dressing with good water absorption effect and good medicine release effect is urgently needed to be provided.
Disclosure of Invention
The invention aims to provide a medical dressing containing high-molecular water-absorbent resin, which can effectively absorb moisture, blood, tissue fluid and the like at a wound, avoid wound infection and prevent medicines in a medicine placing layer from entering the wound.
The invention also aims to provide a preparation method of the medical dressing containing the high-molecular water-absorbent resin, which is simple and convenient to operate, can effectively reduce the operation difficulty of operators, can increase the preparation efficiency and is convenient to popularize.
The technical problem to be solved by the invention is realized by adopting the following technical scheme.
The embodiment of the application provides a medical dressing containing high-molecular water-absorbent resin, which comprises a moisture absorption layer, an adhesive layer and a medicine placing layer, wherein the moisture absorption layer is used for being attached to skin, the adhesive layer is used for adhering adhesive cloth, and the medicine placing layer is positioned between the moisture absorption layer and the adhesive layer; the water absorbing layer comprises high molecular water absorbing resin and vaseline, the medicine releasing layer comprises an antibacterial agent, recombinant human epidermal growth factor and sodium hyaluronate, and the bonding layer is polyurethane. Wherein the hygroscopic layer can be closely attached to the wound of the wounded, thereby absorbing the moisture, blood, tissue fluid and the like at the wound, further avoiding providing a proper growth environment for the growth of bacteria and viruses because of the residual moisture, blood, tissue fluid and the like, further avoiding the wound from being polluted by infectious microbes, wherein the high molecular water-absorbing resin in the water-absorbing layer can react with water to be dissociated so as to form hydrogel molecules with wider space intervals, the medicine in the medicine-placing layer can more easily permeate into the wound of the wounded under the permeation action of the hydrogel molecules, thereby playing the roles of sterilization, inflammation diminishing and repair on the wound of the wounded, further improving the healing efficiency of the wound of the wounded while avoiding the wound infection of the wounded, thereby playing a better repairing role on the wound of the patient, and the adhesive layer can firmly fix the whole dressing and the adhesive cloth, thereby the whole dressing can be stably fixed on the adhesive layer to ensure that the dressing is completely attached to the wound of the wounded.
In addition, the embodiment of the application also provides a preparation method of the medical dressing containing the high-molecular water-absorbent resin, which comprises the following steps of mixing the recombinant human epidermal growth factor, the antibacterial agent and the sodium hyaluronate, and then sequentially heating, cooling and drying to obtain a drug release layer; heating and softening vaseline, mixing with high molecular water-absorbent resin to obtain a mixture, heating the mixture to a molten state, and vacuum compressing to obtain a moisture absorption layer; and sequentially compressing the adhesive layer, the medicine placing layer and the moisture absorption layer in vacuum to obtain the medical dressing containing the high-molecular water-absorbent resin. The preparation method comprises the steps of mixing the recombinant human epidermal growth factor and the antibacterial agent with sodium hyaluronate to enable the recombinant human epidermal growth factor and the antibacterial agent to be uniformly dispersed in the sodium hyaluronate, so that the medicine layer can be uniformly put in the medicine putting process, and then heating, cooling and drying to convert the sodium hyaluronate into sodium hyaluronate gel, so that the antibacterial agent and the recombinant human epidermal growth factor can be conveniently infiltrated into a wound of a human body; the preparation method is simple and easy to operate, convenient to popularize and convenient for large-scale batch production.
Compared with the prior art, the embodiment of the invention has at least the following advantages or beneficial effects:
the embodiment of the invention provides a medical dressing containing high molecular water-absorbent resin, wherein a moisture absorption layer of the dressing can effectively absorb moisture, blood, tissue fluid and the like at a wound, after moisture absorption, the high molecular water-absorbent resin in the moisture absorption layer can react with water and swell, so that the aperture of the moisture absorption layer is increased, and further beneficial components in a medicine placing layer can fully pass through the moisture absorption layer to enter the wound of a wounded to fully act on the wound, so that the wound infection is avoided, and the wound is repaired.
The embodiment of the invention also provides a preparation method of the medical dressing containing the high-molecular water-absorbent resin, the preparation method is characterized in that the recombinant human epidermal growth factor and the antibacterial agent are mixed with the sodium hyaluronate, so that the recombinant human epidermal growth factor and the antibacterial agent can be uniformly dispersed in the sodium hyaluronate, the uniform medicine release of a medicine release layer in a medicine release process is ensured, and then the sodium hyaluronate is converted into sodium hyaluronate gel through heating, cooling and drying, so that the antibacterial agent and the recombinant human epidermal growth factor can conveniently permeate into a wound of a human body; the preparation method is simple and easy to operate, convenient to popularize and convenient for large-scale batch production.
Detailed Description
In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below. The examples, in which specific conditions are not specified, were conducted under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used are not indicated by the manufacturer, and are all conventional products available commercially.
It should be noted that the embodiments and features of the embodiments in the present application may be combined with each other without conflict. The present invention will be described in detail below with reference to specific examples.
The embodiment of the application provides a medical dressing containing high-molecular water-absorbent resin, which comprises a moisture absorption layer, an adhesive layer and a medicine placing layer, wherein the moisture absorption layer is used for being attached to skin, the adhesive layer is used for adhering adhesive cloth, and the medicine placing layer is positioned between the moisture absorption layer and the adhesive layer; the water absorbing layer comprises high molecular water absorbing resin and vaseline, the medicine releasing layer comprises an antibacterial agent, recombinant human epidermal growth factor and sodium hyaluronate, and the bonding layer is polyurethane. Wherein the hygroscopic layer can be closely attached to the wound of the wounded, thereby absorbing the moisture, blood, tissue fluid and the like at the wound, further avoiding providing a proper growth environment for the growth of bacteria and viruses because of the residual moisture, blood, tissue fluid and the like, further avoiding the wound from being polluted by infectious microbes, wherein the high molecular water-absorbing resin in the water-absorbing layer can react with water to be dissociated so as to form hydrogel molecules with wider space intervals, the medicine in the medicine-placing layer can more easily permeate into the wound of the wounded under the permeation action of the hydrogel molecules, thereby playing the roles of sterilization, inflammation diminishing and repair on the wound of the wounded, further improving the healing efficiency of the wound of the wounded while avoiding the wound infection of the wounded, thereby playing a better repairing role on the wound of the patient, and the adhesive layer can firmly fix the whole dressing and the adhesive cloth, therefore, the whole dressing can be stably fixed on the bonding layer to ensure that the dressing is completely attached to the wound of a wounded person, the dressing can be matched with ringer's solution or normal saline, after the dressing is attached to the wound, the microcirculation is formed by utilizing the osmotic pressure difference between human body seepage and the ringer's solution or the normal saline, and the purpose of cleaning the wound is achieved.
A high molecular water-absorbing resin, SAP for short, is a typical functional high molecular material, SAP for short. It can absorb hundreds of times, even thousands of times its own weight of water and has a strong water-retaining capacity, so it is also called super absorbent or high water-retaining agent. In terms of chemical structure, the super absorbent resin is a low-crosslinking degree or partially-crystallized high molecular polymer with a plurality of hydrophilic groups, and can immediately and rapidly generate electrolysis after reacting with water, so as to dissociate into ions with positive electricity and negative electricity, the dissociated positive ions and negative ions have stronger affinity with water, have strong hydrophilicity and water retention property, can rapidly absorb water which is hundreds times or even thousands times heavier than the self weight, and after absorbing water, the gaps among the ions are increased, and a stable hydrogel structure is formed, so that beneficial ingredients in the drug release layer can penetrate through the hydrogel layer to directly act on the wound position of a wounded person, thereby avoiding wound infection and immediately repairing the wound, and the water absorption capacity of the high molecular water absorbent resin is 10cm2The liquid absorption can reach more than 130 g.
The antibacterial agent is a medicament for preventing and treating plant diseases caused by various pathogenic microorganisms. An agent which kills or inhibits the growth of pathogenic microorganisms without interfering with the normal growth of plants. Fungicides can be classified according to mode of action, source of raw material and chemical composition. Internationally, they are generally referred to as agents for controlling various types of pathogenic microorganisms. The antibacterial agent mainly comprises an inorganic antibacterial agent, an organic antibacterial agent, a natural antibacterial agent and the like, wherein the inorganic antibacterial agent mainly has the characteristics of good temperature resistance, wide antibacterial spectrum, long effective bacteriostasis time, low toxic and side effects, no drug resistance, high reliability and the like, but the inorganic antibacterial agent has higher manufacturing cost and poorer effects on fungi, mould and the like; the organic antibacterial agent mainly has the advantages of high sterilization speed, strong sterilization capability, convenient processing, good color stability and the like, but has poor heat resistance, is easy to precipitate in a solvent environment and the like; the natural antibacterial agent mainly has the characteristic of high antibacterial efficiency, but the natural antibacterial agent has the disadvantages of low yield, difficult processing, poor heat resistance and short service life; because a single antibacterial agent always has some defects to cause incomplete functions of the antibacterial agent, the multiple antibacterial agents are preferably combined for use, so that the defects of the various antibacterial agents are made up, and the antibacterial effect of the finally prepared medicine release layer is further improved; polyurethane (PU), the full name of which is polyurethane, is a high molecular compound. This product was produced in 1937 by Otto Bayer et al. Polyurethanes fall into the two main categories of polyester and polyether. They can be made into polyurethane plastics (mainly foamed plastics), polyurethane fibers (Chinese called spandex), polyurethane rubber and elastomers, and are common materials for making adhesives.
In some embodiments of the present invention, the weight ratio of the polymeric water-absorbent resin to the vaseline is 1: (3-4). The high molecular water-absorbing resin and the vaseline in the weight proportion range can not cause the unstable structure of the whole moisture-absorbing layer and be easy to dissociate because of the overhigh content of the high molecular water-absorbing resin and the overlow content of the vaseline, and can not cause the poor moisture-absorbing effect of the whole moisture-absorbing layer because of the overlow content of the high molecular water-absorbing resin and the overhigh content of the vaseline.
In some embodiments of the present invention, the polymeric water absorbent resin includes acrylamide, ammonium cetyl dimethyl allyl chloride, ammonium persulfate, and N, N-methylene bisacrylamide. Acrylamide of the formula C3H5NO, molecular weight 71.08, is colorless transparent flaky crystal, odorless, and toxic. Dissolving in water and ethanol, and slightly dissolving in benzene and toluene. The resin is easy to sublime and polymerize, so that the polymer water-absorbing resin is easy to generate a polymerization reaction, and the polymer water-absorbing resin is selected as a main raw material for preparing the polymer water-absorbing resin; the hexadecyl dimethyl allyl ammonium chloride is mainly synthesized by chloropropene and N, N-dimethyl hexadecylamine (CTA), and the monomer has strong hydrophobic effect and can separate a small amount of moisture in the air so as to avoid the airThe water in the water tank reacts with the high molecular water-absorbing resin immediately; ammonium persulfate, also known as ammonium peroxodisulfate, is an ammonium salt of formula (NH)4)2S2O8The molecular weight is 228.201, the catalyst has strong oxidizing property and corrosiveness, and can create proper reaction conditions for the crosslinking of acrylamide and hexadecyl dimethyl allyl ammonium chloride through the strong oxidizing property; n, N-methylene bisacrylamide as white powdery crystals. The crosslinking agent has no smell and extremely low hygroscopicity, and is mainly used as a crosslinking agent to promote the crosslinking reaction of acrylamide and hexadecyl dimethyl allyl ammonium chloride.
In some embodiments of the present invention, the weight ratio of the acrylamide, the cetyl dimethyl allyl ammonium chloride, the ammonium persulfate, and the N, N-methylene bisacrylamide is (95-99): 0.4-0.6: (0.2-0.3): 0.2-0.3. The proportion interval can ensure that the size of the gaps of the prepared high-molecular water-absorbent resin is proper, the water absorption efficiency of the prepared high-molecular water-absorbent resin is not reduced because the gaps of the prepared high-molecular water-absorbent resin are too large, and the high-molecular water-absorbent resin and vaseline are not easy to mix uniformly because the gaps of the high-molecular water-absorbent resin are too small.
In some embodiments of the present invention, the polymeric water absorbent resin has a degree of hydrolysis of 84 to 90%. When the hydrolysis of the salt reaches the balance, the ratio of the number of molecules of the hydrolyzed salt to the total number of molecules of the salt dissolved in the solution is called the hydrolysis degree of the salt, and the hydrolysis degree interval can ensure the normal crosslinking of hexadecyl dimethyl allyl ammonium chloride and acrylamide, and meanwhile, the instability of the structure of the prepared moisture absorption layer caused by the overhigh hydrolysis degree can be avoided, and the instability of the structure of the prepared high polymer water absorption resin caused by the overlow hydrolysis degree can be avoided.
In some embodiments of the invention, the antimicrobial agent comprises silver ion, AB2O4One or more of silver-carrying silicate, silver-carrying phosphate and sodium diacetate. The sterilization principle of the antibacterial agent is that the silver ions are mainly infiltrated into bacteria by utilizing the ion state of the antibacterial agent, so that the antibacterial agent is combined with protein in the bacteria to lose activity, and finally the bacteria are broken and die; AB2O4Is a composite antibodyMicrobial agents, known as spinels, are capable of destroying the biological structure of bacteria, molds and fungi, thereby inactivating them; the silver-carrying silicate and the silver-carrying phosphate are silver-carrying nano antibacterial materials, and the preparation principle mainly comprises that the microporous structure of a nano carrier material is utilized, a specific cation exchange method is adopted to exchange anions into micropores of a nano carrier, and then the silver-carrying silicate and the silver-carrying phosphate are prepared by adopting the process technologies of low-temperature dehydration, high-temperature stabilization and the like of silver ions in the micropores, so that the sterilization effect is achieved; the molecular formula of the sodium diacetate is C4H7NaO4It is also called sodium diacetate and sodium diacetate, is a novel food and feed mildew preventive, sour agent and modifier with stable properties and low price, and has good inhibition effect on mould, fungus and the like.
In some embodiments of the present invention, the thickness of the drug-releasing layer is 2-3mm, the thickness of the moisture-absorbing layer is 1-2mm, and the thickness of the adhesive layer is 1-2 mm. The thickness interval of the drug release layer can ensure that the beneficial components contained in the drug release layer are sufficient, and meanwhile, the drug release layer cannot be extruded to the moisture absorption layer or the bonding layer due to the excessively thick thickness of the drug release layer; the thickness interval of the moisture absorption layer can ensure that the moisture absorption layer can effectively absorb blood, moisture, tissue fluid and the like at the wound and can not permeate into the medicine placing layer, and when the thickness of the moisture absorption layer is too high, beneficial components in the medicine placing layer can hardly permeate into the wound of the wound through the moisture absorption layer; when the thickness of the adhesive layer is too high or too thin, the adhesiveness between the adhesive layer and the patch is deteriorated.
In addition, the embodiment of the application also provides a preparation method of the medical dressing containing the high-molecular water-absorbent resin, which comprises the steps of mixing the recombinant human epidermal growth factor, the antibacterial agent and the sodium hyaluronate, and then sequentially heating, cooling and drying to obtain a drug release layer; heating and softening vaseline, mixing with high molecular water-absorbent resin to obtain a mixture, heating the mixture to a molten state, and vacuum compressing to obtain a moisture absorption layer; and sequentially compressing the adhesive layer, the medicine placing layer and the moisture absorption layer in vacuum to obtain the medical dressing containing the high-molecular water-absorbent resin. The preparation method comprises the steps of mixing the recombinant human epidermal growth factor and the antibacterial agent with sodium hyaluronate to enable the recombinant human epidermal growth factor and the antibacterial agent to be uniformly dispersed in the sodium hyaluronate, so that the medicine layer can be uniformly put in the medicine putting process, and then heating, cooling and drying to convert the sodium hyaluronate into sodium hyaluronate gel, so that the antibacterial agent and the recombinant human epidermal growth factor can be conveniently infiltrated into a wound of a human body; the preparation method is simple and easy to operate, convenient to popularize and convenient for large-scale batch production.
In some embodiments of the invention, the heating temperature is 50-60 ℃, the cooling temperature is 5-10 ℃, the drying temperature is 30-40 ℃, and the drying time is 2-3 h. The heated temperature interval can enable the recombinant human epidermal growth factor and the antibacterial agent to be fully mixed with the sodium hyaluronate, and then the recombinant human epidermal growth factor and the antibacterial agent can be fully dispersed in the sodium hyaluronate, so that the medicine layer can be uniformly put with medicine, and the cooled temperature interval, the dried temperature and the time interval can enable the sodium hyaluronate to be fully converted into a gel state, so that the antibacterial agent and the recombinant human epidermal growth factor are dispersed in the sodium hyaluronate gel.
In some embodiments of the present invention, the temperature of the vacuum compression is 0-5 ℃, and the time of the vacuum compression is 15-20 min. This vacuum compression's temperature interval and time interval can make the stable combination of putting medicine layer, hygroscopic layer and adhesive linkage be in the same place, avoid taking place to loosen between the layer of difference and take off.
The features and properties of the present invention are described in further detail below with reference to examples.
Example 1
The embodiment provides a medical dressing containing high-molecular water-absorbent resin, which comprises the following raw materials of high-molecular water-absorbent resin, vaseline, sodium hyaluronate, recombinant human epidermal growth factor, acrylamide, hexadecyl dimethyl allyl ammonium chloride, ammonium persulfate, N-methylene bisacrylamide and silver ions.
The embodiment provides a preparation method of a medical dressing containing high-molecular water-absorbent resin, which comprises the following steps of mixing acrylamide, hexadecyl dimethyl allyl ammonium chloride, ammonium persulfate and N, N-methylene-bisacrylamide to prepare the high-molecular water-absorbent resin for later use; mixing the recombinant human epidermal growth factor, the antibacterial agent and the sodium hyaluronate, sequentially heating at 50 ℃, cooling at 5 ℃, and drying at 30 ℃ for 2 hours to obtain a drug release layer; heating and softening vaseline, mixing with high molecular water-absorbent resin to obtain a mixture, heating the mixture to a molten state, and vacuum compressing to obtain a moisture absorption layer; sequentially compressing the adhesive layer, the medicine placing layer and the moisture absorption layer at 0 deg.C under vacuum for 15min to obtain the medical dressing containing high molecular water-absorbent resin.
Example 2
The embodiment provides a medical dressing containing high-molecular water-absorbent resin, which comprises the following raw materials of high-molecular water-absorbent resin, vaseline, sodium hyaluronate, recombinant human epidermal growth factor, acrylamide, hexadecyl dimethyl allyl ammonium chloride, ammonium persulfate, N-methylene bisacrylamide and silver ions.
The embodiment provides a preparation method of a medical dressing containing high-molecular water-absorbent resin, which comprises the following steps of mixing acrylamide, hexadecyl dimethyl allyl ammonium chloride, ammonium persulfate and N, N-methylene-bisacrylamide to prepare the high-molecular water-absorbent resin for later use; mixing the recombinant human epidermal growth factor, the antibacterial agent and the sodium hyaluronate, sequentially heating at 60 ℃, cooling at 10 ℃, and drying at 40 ℃ for 3 hours to obtain a drug release layer; heating and softening vaseline, mixing with high molecular water-absorbent resin to obtain a mixture, heating the mixture to a molten state, and vacuum compressing to obtain a moisture absorption layer; sequentially compressing the adhesive layer, the medicine placing layer and the moisture absorption layer at 5 deg.C under vacuum for 20min to obtain the medical dressing containing high molecular water-absorbent resin.
Example 3
The embodiment provides a medical dressing containing high-molecular water-absorbent resin, which comprises the following raw materials of high-molecular water-absorbent resin, vaseline, sodium hyaluronate, recombinant human epidermal growth factor, acrylamide, hexadecyl dimethyl allyl ammonium chloride, ammonium persulfate, N-methylene bisacrylamide and silver ions.
The embodiment provides a preparation method of a medical dressing containing high-molecular water-absorbent resin, which comprises the following steps of mixing acrylamide, hexadecyl dimethyl allyl ammonium chloride, ammonium persulfate and N, N-methylene-bisacrylamide to prepare the high-molecular water-absorbent resin for later use; mixing the recombinant human epidermal growth factor, the antibacterial agent and the sodium hyaluronate, sequentially heating at 55 ℃, cooling at 8 ℃, and drying at 35 ℃ for 2.5 hours to obtain a drug release layer; heating and softening vaseline, mixing with high molecular water-absorbent resin to obtain a mixture, heating the mixture to a molten state, and vacuum compressing to obtain a moisture absorption layer; sequentially compressing the adhesive layer, the medicine placing layer and the moisture absorption layer at 2.5 deg.C under vacuum for 18min to obtain the medical dressing containing high molecular water-absorbent resin.
Example 4
The embodiment provides a medical dressing containing high-molecular water-absorbent resin, which comprises the following raw materials of high-molecular water-absorbent resin, vaseline, sodium hyaluronate, recombinant human epidermal growth factor, acrylamide, hexadecyl dimethyl allyl ammonium chloride, ammonium persulfate, N-methylene bisacrylamide and silver ions.
The embodiment provides a preparation method of a medical dressing containing high-molecular water-absorbent resin, which comprises the following steps of mixing acrylamide, hexadecyl dimethyl allyl ammonium chloride, ammonium persulfate and N, N-methylene-bisacrylamide to prepare the high-molecular water-absorbent resin for later use; mixing the recombinant human epidermal growth factor, the antibacterial agent and the sodium hyaluronate, sequentially heating at 53 ℃, cooling at 7 ℃, and drying at 34 ℃ for 2.3 hours to obtain a drug release layer; heating and softening vaseline, mixing with high molecular water-absorbent resin to obtain a mixture, heating the mixture to a molten state, and vacuum compressing to obtain a moisture absorption layer; sequentially compressing the adhesive layer, the medicine placing layer and the moisture absorption layer at 2.3 deg.C under vacuum for 17min to obtain the medical dressing containing high molecular water-absorbent resin.
Example 5
The embodiment provides a medical dressing containing high-molecular water-absorbent resin, which comprises the following raw materials of high-molecular water-absorbent resin, vaseline, sodium hyaluronate, recombinant human epidermal growth factor, acrylamide, hexadecyl dimethyl allyl ammonium chloride, ammonium persulfate, N-methylene bisacrylamide and silver ions.
The embodiment provides a preparation method of a medical dressing containing high-molecular water-absorbent resin, which comprises the following steps of mixing acrylamide, hexadecyl dimethyl allyl ammonium chloride, ammonium persulfate and N, N-methylene-bisacrylamide to prepare the high-molecular water-absorbent resin for later use; mixing the recombinant human epidermal growth factor, the antibacterial agent and the sodium hyaluronate, sequentially heating at 56 ℃, cooling at 9 ℃, and drying at 36 ℃ for 2.6 hours to obtain a drug release layer; heating and softening vaseline, mixing with high molecular water-absorbent resin to obtain a mixture, heating the mixture to a molten state, and vacuum compressing to obtain a moisture absorption layer; sequentially compressing the adhesive layer, the medicine placing layer and the moisture absorption layer at 2.8 deg.C under vacuum for 19min to obtain the medical dressing containing high molecular water-absorbent resin.
Example 6
The embodiment provides a medical dressing containing high-molecular water-absorbent resin, which comprises the following raw materials of high-molecular water-absorbent resin, vaseline, sodium hyaluronate, recombinant human epidermal growth factor, acrylamide, hexadecyl dimethyl allyl ammonium chloride, ammonium persulfate, N-methylene bisacrylamide and silver ions.
The embodiment provides a preparation method of a medical dressing containing high-molecular water-absorbent resin, which comprises the following steps of mixing acrylamide, hexadecyl dimethyl allyl ammonium chloride, ammonium persulfate and N, N-methylene-bisacrylamide to prepare the high-molecular water-absorbent resin for later use; mixing the recombinant human epidermal growth factor, the antibacterial agent and the sodium hyaluronate, sequentially heating at 51 ℃, cooling at 6 ℃, and drying at 32 ℃ for 2.9 hours to obtain a drug release layer; heating and softening vaseline, mixing with high molecular water-absorbent resin to obtain a mixture, heating the mixture to a molten state, and vacuum compressing to obtain a moisture absorption layer; sequentially compressing the adhesive layer, the medicine placing layer and the moisture absorption layer at 2.2 deg.C under vacuum for 16min to obtain the medical dressing containing high molecular water-absorbent resin.
Test examples
A medical dressing containing a water-absorbent polymer resin obtained in examples 1 to 6 and a commercially available dressing were used as comparative examples, which were cut into a size of 5 square centimeters, and then left to stand at 20 ℃ under a relative humidity of 65% for 24 hours to balance the moisture regain, and the dry weight W (g) was measured, and then the dry weight W1(g) was measured by placing the dry weight in a sufficient amount of physiological saline and placing the same in a 90mm diameter petri dish at 37 ℃ for 30 minutes, and then a forceps was hung in the air for 30 seconds while holding one corner of the dressing.
Equation 1: the hygroscopicity of the dressing per unit weight is (W1-W)/W100%,
equation 2: moisture absorption per unit area 4(W1-W), unit g/(1000 square cm)
The hygroscopicity of the dressing per unit weight to physiological saline was measured in this experiment using the weighing method of formula 1. Each of the dressings of examples 1 to 6 was taken, the packaging material was removed before the test, the dressing was scraped off from the backing with a razor blade, soaked in a sufficient amount of physiological saline, placed in an incubator at 37 ℃ for 24 hours, the surface of the dressing was sucked off with filter paper and weighed, and the water absorption rate was calculated according to equation 1, and the results were shown in Table 1.
TABLE 1 Water absorption of the dressing in physiological saline
Figure BDA0003423399290000131
The results in Table 1 show that the medical dressing containing the high molecular water-absorbent resin prepared by the invention has better water absorption effect.
In summary, the embodiment of the present invention provides a medical dressing containing a high molecular water absorbent resin and a preparation method thereof:
the embodiment of the invention provides a medical dressing containing high molecular water-absorbent resin, wherein a moisture absorption layer of the dressing can effectively absorb moisture, blood, tissue fluid and the like at a wound, after moisture absorption, the high molecular water-absorbent resin in the moisture absorption layer can react with water and swell, so that the aperture of the moisture absorption layer is increased, and further beneficial components in a medicine placing layer can fully pass through the moisture absorption layer to enter the wound of a wounded to fully act on the wound, so that the wound infection is avoided, and the wound is repaired.
The embodiment of the invention also provides a preparation method of the medical dressing containing the high-molecular water-absorbent resin, the preparation method is characterized in that the recombinant human epidermal growth factor and the antibacterial agent are mixed with the sodium hyaluronate, so that the recombinant human epidermal growth factor and the antibacterial agent can be uniformly dispersed in the sodium hyaluronate, the uniform medicine release of a medicine release layer in a medicine release process is ensured, and then the sodium hyaluronate is converted into sodium hyaluronate gel through heating, cooling and drying, so that the antibacterial agent and the recombinant human epidermal growth factor can conveniently permeate into a wound of a human body; the preparation method is simple and easy to operate, and convenient to popularize and large-scale batch production, and the dressing can be matched with ringer's solution or normal saline, and after being pasted on a wound surface, the dressing can form microcirculation by utilizing the osmotic pressure difference between human body seepage solution and ringer's solution or normal saline, so that the purpose of cleaning the wound surface is achieved.
The embodiments described above are some, but not all embodiments of the invention. The detailed description of the embodiments of the present invention is not intended to limit the scope of the invention as claimed, but is merely representative of selected embodiments of the invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Claims (10)

1. The medical dressing containing the high-molecular water-absorbent resin is characterized by comprising a moisture absorption layer, an adhesive layer and a medicine placing layer, wherein the moisture absorption layer is used for being attached to skin, the adhesive layer is used for adhering adhesive cloth, and the medicine placing layer is positioned between the moisture absorption layer and the adhesive layer;
the drug releasing layer comprises an antibacterial agent, recombinant human epidermal growth factors and sodium hyaluronate, and the bonding layer is polyurethane.
2. The medical dressing containing the high molecular water absorbent resin according to claim 1, wherein the weight ratio of the high molecular water absorbent resin to the vaseline is 1: (3-4).
3. The medical dressing containing the high-molecular water-absorbent resin according to claim 2, wherein the high-molecular water-absorbent resin comprises acrylamide, hexadecyldimethylallylammonium chloride, ammonium persulfate and N, N-methylenebisacrylamide.
4. The medical dressing containing the water absorbent polymer resin according to claim 3, wherein the weight ratio of the acrylamide, the hexadecyl dimethyl allyl ammonium chloride, the ammonium persulfate and the N, N-methylene bisacrylamide is (95-99): 0.4-0.6): 0.2-0.3.
5. The medical dressing containing the high molecular water absorbent resin according to claim 3, wherein the degree of hydrolysis of the high molecular water absorbent resin is 84 to 90%.
6. The medical dressing containing the high molecular water absorbent resin as claimed in claim 1, wherein the antibacterial agent comprises silver ions, AB2O4One or more of silver-carrying silicate, silver-carrying phosphate and sodium diacetate.
7. The medical dressing containing the high-molecular water-absorbent resin according to claim 1, wherein the thickness of the drug-releasing layer is 2-3mm, the thickness of the moisture-absorbing layer is 1-2mm, and the thickness of the adhesive layer is 1-2 mm.
8. A preparation method of the medical dressing containing the high molecular water absorbent resin according to the claims 1 to 7, characterized by comprising the following steps of mixing the recombinant human epidermal growth factor, the antibacterial agent and the sodium hyaluronate, and then heating, cooling and drying the mixture in sequence to obtain the drug release layer;
heating and softening the vaseline, mixing the vaseline with the high-molecular water-absorbent resin to obtain a mixture, heating the mixture to a molten state, and compressing the mixture in vacuum to obtain the moisture absorption layer;
and sequentially compressing the bonding layer, the medicine placing layer and the moisture absorption layer in vacuum to obtain the medical dressing containing the high-molecular water-absorbent resin.
9. The method for preparing the medical dressing containing the high molecular water absorbent resin according to claim 8, wherein the heating temperature is 50-60 ℃, the cooling temperature is 5-10 ℃, the drying temperature is 30-40 ℃, and the drying time is 2-3 h.
10. The method for preparing the medical dressing containing the high molecular water absorbent resin according to claim 8, wherein the temperature of the vacuum compression is 0-5 ℃, and the time of the vacuum compression is 15-20 min.
CN202111571199.XA 2021-12-21 2021-12-21 Medical dressing containing high-molecular water-absorbent resin and preparation method thereof Pending CN114209870A (en)

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CN103374099A (en) * 2012-04-16 2013-10-30 连宗旭 Preparation method of diene quaternary ammonium salt antibacterial super absorbent polymer (SAP)
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