CN1141979C - One-pack preparation for disinfection, neutralization and cleaning of contact lenses and method of disinfection, neutralization and cleaning - Google Patents
One-pack preparation for disinfection, neutralization and cleaning of contact lenses and method of disinfection, neutralization and cleaning Download PDFInfo
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- CN1141979C CN1141979C CNB971964157A CN97196415A CN1141979C CN 1141979 C CN1141979 C CN 1141979C CN B971964157 A CNB971964157 A CN B971964157A CN 97196415 A CN97196415 A CN 97196415A CN 1141979 C CN1141979 C CN 1141979C
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Abstract
The present invention provides a preparation for simultaneously sterilizing, neutralizing and washing soft contact lenses, and a method for conveniently, effectively and safely using the preparation. The liquid combined preparation used for sterilizing, neutralizing and washing soft contact lenses is characterized in that the preparation is composed of a first preparation and a second preparation, wherein the first preparation contains iodine sterilizing agents and protein clastic enzymes, the second preparation contains reducing agents and foaming agents and has a release delay coating, and at least one of the first preparation and the second preparation contains non-ionic surface active agents. Contaminated soft contact lenses are put into yellow and brown water solution colored by iodine molecules, and after the water solution is approximately colorless, the lenses are taken out from the water solution, so that a series of maintenance of sterilization, neutralization, washing, etc. can be implemented conveniently.
Description
The present invention relates to be used for a liquid type combination preparation of contact lens disinfection, neutralization and washing and wash the method for contact lens with its.In more detail, just relate to be applicable to fast and easily and sterilize, neutralize and wash a liquid type combination preparation of contaminated contact lens and the method for washing with it.
The method of soft contact lens of being used at present to sterilize can roughly be divided into boiling sterilization and chemical disinfection.Scalding is fundamentally effective to the sterilization of all microorganisms such as antibacterial, virus, mycete, but the protein that adsorbs on soft contact lens and other adsorbate are because of the heat degeneration and solidify, become the reason of eyeglass nebulousurine, and for a long time repeatedly heating can make eyeglass produce distortion and variable color.In addition, the method has out of use inconvenience when non-transformer.
About chemical disinfection is known several different methods arranged, the disinfectant solution of 3% hydrogen peroxide, biguanides is lower to the microbial antibacterial effect of some kind.And when misuse corneal epithelial and the stimulation of conjunctiva strong excessively, might cause the conjunctiva obstacle.
In various halogen antibacterial, the iodine series bactericidal agent is fungicidal effectiveness and the chemosterilant all very outstanding to safety two aspects of eye.Example as iodine class disinfectant, at No. 1604020 description of British patent, No. 4312833 description of United States Patent (USP), Contacto, 33～37 pages (1975), Japanese contact lens can will No.23 150～154 pages (1981), Japanese contact lenss can will No.20 on the books in 96～101 pages (1978 years).But, in these methods, with the residual disinfectant in iodine series bactericidal agent sterilization back removing and neutralization utilizes that iodine is distinctive to distil or weak reductant carries out naturally, need long time and may neutralize insufficient.Consequently, may make the eyeglass variable color because of in the substrate of soft contact lens, having adsorbed iodine reagent, and eyeglass is out of shape and deterioration because of iodine and lens materials reaction.
Further, though this Operand is safer to eyes, but because of insufficient absorption in eyeglass that neutralizes, when accumulating, iodine class medicine is slowly emitted when wearing, as AnnalsOphthalmology, put down in writing in 361～364 pages (1981), may cause the people's of allergic constitution eyes inflammation and cornea obstacle.A kind of method is disclosed in open communique WO96/00590 in the world and WO96/00591, wherein in reducing solution, add than the more Operand of the contained Reducing agent aequum of oxidation, contact lens is carried out disinfection, and then add the residual Operand of Reducing agent reduction.In addition, in the maintenance of soft contact lens, it also is very important removing the protein and the lipid that adhere on the eyeglass, therefore need be used for the detergent of this purpose.But a liquid type combination preparation that integrates iodine disinfectant, nertralizer, proteolytic enzyme and surfactant is also not known.
The object of the present invention is to provide a liquid type combination preparation that can in same solution, carry out disinfection, neutralize and wash.
Other purpose of the present invention is to provide and is applicable to fast and easily a liquid type combination preparation of sterilizing, neutralizing and washing contaminated contact lens.
The present invention further other purpose be to provide use the shortcoming that demonstrates the higher iodine disinfectant of strong disinfecting effect and safety, improved the preparation of neutralization method before using, combine by 2 kinds of preparations, be used for sterilizing easily, neutralize and wash a liquid type combination preparation of soft contact lens.
The present invention further other purpose is to provide the method for using a liquid type combination preparation of the present invention to wash contaminated contact lens fast and easily.
The present invention further other purpose and advantage is as described below.
According to the present invention, at first, above-mentioned purpose of the present invention and advantage can by (A) contain the 1st preparation of iodine series bactericidal agent and proteolytic enzyme and (B) contain Reducing agent and foaming agent and have that the 2nd preparation of delayed release coating combines, the 1st preparation and the 2nd preparation at least aly contain liquid type combination preparation nonionic surfactant, that be used for contact lens disinfection, neutralization and washing and reach.
Combination preparation of the present invention is made up of the 1st preparation (A) and the 2nd preparation (B), has at least a side to contain nonionic surfactant among them.
The 1st preparation contains iodine series bactericidal agent and proteolytic enzyme, according to circumstances also can contain nonionic surfactant.
Being applicable to that iodine series bactericidal agent of the present invention is known very early has an iodine molecule (I
2) be embedded in povidone-iodine or PVA iodine in polyvinylpyrrolidone (PVP) or the polyvinyl alcohol macromole such as (PVA).The bonded iodine preparation of these macromolecules is compared with free iodine preparation, have 1. for water miscible, 2. stabilisation has the unsettled iodine molecule of sublimability and makes it to be solid-state, 3. feature such as toxicity reduction, and it has the powerful bactericidal action the same with the iodine preparation of dissociating, and is very outstanding disinfectant.That is, this disinfectant has antimicrobial spectrum widely to antibacterial, antibiotic resistant bacteria, mycete, virus etc.
Be applicable to that proteolytic enzyme of the present invention must fully keep the washing force to eyeglass protein stain in the presence of as the iodine disinfectant of strong oxidizer.Particularly methylthio group is that sulphur atoms such as mercapto, disulfide group are easily by the oxidation of iodine compound institute, so have the enzyme of a plurality of this methylthio groups, be that papain, bromelain matter, ficin, pancreatin and cathepsin etc. can make when coexisting with iodine disinfectant enzyme tire to reduce greatly, do not recommend as the preferred enzyme detergent in the present invention.
The result who carries out stability experiment with various enzymes in the presence of this Operand shows that the enzyme in proteolytic enzyme that the bacillus microorganism belonging to genus is produced and animal pancreas source is more stable.
This commercially available protease for example has Biotamilase (the assorted Biochem Industrial Co., Ltd. of the loud, high-pitched sound of receiving), protease N " Amano " (Amono Pharmacevtical Co., Ltd.), subtilin A, Alcarase, Esperase, trypsin, Chymotrypsin (Novo Nordisk Bioindustry company) etc.From these enzymes, select suitable use.
The iodine series bactericidal agent that preferably contains 0.01～50% weight (based on the 1st preparation) in the 1st preparation more preferably contains the iodine series bactericidal agent of 0.1～15% weight.As combination preparation of the present invention, when being dissolved in the 1st preparation in the dissolving usefulness aqueous solution, the iodine series bactericidal agent in aqueous solution preferably contains 1～5000ppm as available iodine concentration, more preferably contains 10～1500ppm.During the discontented 1ppm of concentration, sterilizing power is low, surpass 5000ppm then in and time lengthening and influential to eyeglass, use and have any problem.
In addition, in the 1st preparation, proteolytic enzyme preferably contains 0.01～50% weight (based on the 1st preparation), more preferably contains 0.1～20% weight.Like this, as combination preparation of the present invention, the 1st preparation is dissolved in dissolving when using aqueous solution, can tire according to clean result and enzyme for the proteolytic enzyme in aqueous solution suitably determines its concentration, but the concentration of preferred 0.0001～0.5% weight.
As the nonionic surfactant that can in the 1st preparation, contain, for example preferably use Poloxamer, Poloxamine, macromolecule sorbate 80, stearic acid Polyoxyethylene este 40 and polyoxyethylene hardened castor oil 60 etc.
When containing nonionic surfactant in the 1st preparation, preferably contain 0.01～50% weight (based on the 1st preparation), more preferably contain 0.1～20% weight.When being dissolved in combination preparation of the present invention in the dissolving usefulness aqueous solution, the nonionic surfactant in the aqueous solution preferably uses 0.0001～0.5% weight, more preferably 0.001～0.2% weight.
On the other hand, the 2nd preparation contains sulfur-bearing Reducing agent, foaming agent, and contains nonionic surfactant as required, and it also has delayed release coating simultaneously.
As Reducing agent, can use known powerful Reducing agent as iodine and halogenating agent.So residual iodine molecule on the soft contact lens after particularly sodium sulfite, sodium sulfite, sodium thiosulfate, ascorbic acid, sodium ascorbate etc. can reduce effectively and sterilize is preferred especially.
Preferably contain the Reducing agent of 0.01～50% weight based on the 2nd preparation, more preferably contain 0.1～20% weight.
When being dissolved in Purified Water as combination preparation of the present invention the 2nd preparation, the final and iodine series bactericidal agent reaction of Reducing agent, reduction iodine series bactericidal agent.
In addition, as foaming agent, for example preferably use sodium bicarbonate and sodium carbonate etc.
In the 2nd preparation, foaming agent preferably contains 1～80% weight, more preferably contains 10～60% weight.
Further, as the nonionic surfactant that can in the 2nd preparation, contain, can use with the 1st preparation in identical material.
The 2nd preparation also can contain the nonionic surfactant with the 1st preparation same amount.
It is described that the 2nd preparation has the reasons are as follows of delayed release coating.
The aqueous solution of iodine molecule presents from the pitchy to the yellow color because of the difference of its concentration, and iodine is used to be easy to be adsorbed on the organic compound as this statement of facts of developer of silica gel and aluminum oxide film layer chromatography.As the material of the soft contact lens of sterilization objects is that polymer by organic compound such as methacrylic acid derivative, acrylic acid amides derivant and N-vinylpyrrolidones constitutes, iodine molecule adsorbs on the substrate of eyeglass easily during sterilization, makes eyeglass yellowing or brown.The influence that long-time lasting this state then may bring lens materials degeneration and deterioration etc.After the sterilization, iodine molecule is reduced, becomes colourless, safety and eyeglass substrate thing is not almost had the iodine anion of absorbability with this Reducing agent.
So, after sterilizing effectively with iodine, must be promptly with the remaining iodine molecule of Reducing agent reduction.In order to reach this purpose, have delayed release coating in the 2nd preparation, can after finishing the sterilization of contact lens, the 1st preparation discharge Reducing agent etc.
That is to say, when just the eyeglass that pollutes being placed the aqueous solution that contains the 1st preparation and the 2nd preparation simultaneously, at first be that the 1st preparation sterilizes to contact lens and washs, the dissolved destruction of delayed release coating of the 2nd preparation when sterilization roughly finishes, remaining iodine molecule is by Reducing agent reduction (neutralization) contained in the 2nd preparation.The contained foaming agent of the 2nd preparation helps this reduction reaction effectively and sleekly to carry out.
The delayed release coating agent of using preferred for this invention is the cellulose or the gelatin of chemical modification.More preferably hydroxypropyl cellulose (HPC), hydroxypropyl emthylcellulose (HPMC), hydroxyethyl-cellulose (HEC) etc. among this.
Delayed release coating preferably is designed to begin foaming in 1～10 minute.
That is to say, about of sterilization, the washing of the 1st preparation to contact lens, be the sterilization of iodine series bactericidal agent and the washing of proteolytic enzyme, wash fully with Profilin matter catabolic enzyme inactivation in order to sterilize fully, suitably disinfecting time is 1～10 minute, preferably the effective ingredient of the 2nd preparation is played a role.
For reaching this purpose, as dosage form, preferred the 1st preparation is powder or granular formulations and the 2nd preparation is tablet or capsule, perhaps the 2nd preparation is core, the 1st preparation as the skin form (the chip agent is for example arranged) of heart part hereinto that is covered, and perhaps the 1st preparation and the 2nd preparation are in and the form of row arrangement.The dosage form of the two kinds of forms in back can prevent from because of carelessness any preparation to be dropped in the lysate.
Liquid type combination preferred the 1st preparation of system type of the present invention and the 2nd preparation contain with the ratio of the weight ratio 10/90～90/10 of the 1st preparation and the 2nd preparation.
Secondly, according to the present invention, the method of a kind of contact lens disinfection, neutralization and washing is provided equally, it is characterized in that, the contact lens that pollutes placed the yellow that contains the present invention's one liquid type combination preparation solution, roughly be at aqueous solution and again contact lens taken out from this aqueous solution after colourless to brown.
The aqueous solution that dissolves a liquid type combination preparation can contain isotonic agent, buffer agent, chelating agen etc.This aqueous solution preference is dissolved in the aqueous solution that Purified Water is made as at least a isotonic agent that will select, at least a buffer agent of selecting and at least a chelating agen selected from disodiumedetate (EDTA2Na) and ethylenediamine tetraacetic acid,dipotassium salt from phosphate, boric acid and borate from sodium chloride and potassium chloride.In addition, this aqueous solution also can be used as the cleaning mixture of eyeglass after the sterilization of soft contact lens and washing, so it should be the pH such as Zhang He such as tear with the people.
The method of sterilization of the present invention, neutralization and washing is applicable to known property of water-bearing soft contact lens fully.Specifically, be exactly with eyeglass fixed basket internal fixation on the lid of vial with cover, fill in this vial dissolving with aqueous solution after, drop into above-mentioned the 1st preparation and the 2nd preparation simultaneously, have the lid of eyeglass to cover the basket internal fixation, leave standstill after the jolting for several times.At first, the 1st sterilization, detergent dissolution begin sterilization and proteinic washing to the microorganism of adhering on the eyeglass.Then, the 2nd nertralizer begins foaming after 1～10 minute, and the solution and the soft contact lens that are yellow or brown fade gradually, and final naked eyes can be confirmed to become colourless fully.Washing is proceeded during this period, and wash time finished in washing beginning back in 1～600 minute.After the eyeglass of finishing sterilization, neutralization and washing washs with above-mentioned cleaning mixture, for eye wear.
Embodiment
Below with regard to embodiment the present invention is carried out specific description, but the present invention is not limited to this.
Embodiment 1
The 1st preparation (powder)
Composition milligram/preparation
Povidone-iodine (iodine series bactericidal agent) 3
Subtilin A (proteolytic enzyme) 6
Lactose (excipient) 91
The 2nd preparation (tablet)
Composition milligram/preparation
Sodium sulfite (Reducing agent) 3
Poloxamer (nonionic surfactant) 5
Sodium carbonate (foaming agent, pH regulator agent) 30
Citric acid (pH regulator agent) 10
Lactose (excipient) 12
HEC (coating materials) 5
Tablet carries out coating with HEC after being shaped.
Dissolving aqueous solution (liquid)
The composition mg/ml
Sodium chloride (isotonic agent) 8
EDTA2Na (chelating agen) 1
Boric acid (buffer agent) 5
Borax (buffer agent) 1
Purified Water (solvent) is an amount of
Above-mentioned the 1st preparation (powder) and the 2nd preparation (tablet) are packaged in the polyethylene packaging body of aluminum thin film, make a liquid type combination preparation.In addition, will dissolve with aqueous solution (liquid) and be loaded in the PE bottle.
Embodiment 2
The 1st preparation (granule)
Composition milligram/preparation
Povidone-iodine (iodine series bactericidal agent) 3
The trypsin proteolytic enzyme) 3
Stearic acid Polyoxyethylene este 40 (nonionic surfactant) 5
Lactose (excipient) 87
The 2nd preparation (tablet)
Composition milligram/preparation
Sodium sulfite (Reducing agent) 3
Sodium carbonate (foaming agent, pH regulator agent) 30
Citric acid (pH regulator agent) 10
Lactose (excipient) 12
HPMC (coating materials) 5
Tablet carries out coating with HPMC after being shaped.
Dissolving aqueous solution (liquid)
The composition mg/ml
Sodium chloride (isotonic agent) 7
EDTA2Na (chelating agen 1
Potassium dihydrogen phosphate (buffer agent) 1
Sodium hydrogen phosphate (buffer agent) 1.5
Purified Water (solvent) is an amount of
Above-mentioned the 1st preparation (granule) and the 2nd preparation (tablet) are packaged in the polyethylene packaging body of aluminum thin film, make a liquid type combination preparation.In addition, will dissolve with aqueous solution (liquid) and be loaded in the PE bottle.
Embodiment 3
The 1st preparation (powder)
Composition milligram/preparation
Povidone-iodine (iodine series bactericidal agent) 3
The trypsin proteolytic enzyme) 1
Chymotrypsin (proteolytic enzyme) 1
Poloxamer (nonionic surfactant) 5
Lactose (excipient) 90
The 2nd preparation (capsule)
Composition milligram/preparation
Sodium thiosulfate (Reducing agent) 2
Sodium bicarbonate (foaming agent, pH regulator agent) 30
Citric acid (pH regulator agent) 5
Lactose (excipient) 13
Gelatin (capsule agent) 5
Be filled in the gelatine capsule after the shaping particles.
Dissolving aqueous solution (liquid)
The composition mg/ml
Sodium chloride (isotonic agent) 6
EDTA2Na (chelating agen) 1
Boric acid (buffer agent) 6
Borax (buffer agent) 1.5
Purified Water (solvent) is an amount of
Above-mentioned the 1st preparation (powder) and the 2nd preparation (capsule) are packaged in the polyethylene packaging body of aluminum thin film, make a liquid type combination preparation.In addition, will dissolve with aqueous solution (liquid) and be loaded in the PE bottle.Comparative example 1
The 1st preparation (powder)
Composition milligram/preparation
Povidone-iodine (iodine series bactericidal agent) 3
Papain (proteolytic enzyme) 7
Lactose (excipient) 90
The 2nd preparation (tablet)
Composition milligram/preparation
Sodium sulfite (Reducing agent) 3
Poloxamer (nonionic surfactant) 5
Sodium carbonate (foaming agent, pH regulator agent) 30
Citric acid (pH regulator agent) 10
Lactose (excipient) 12
Dissolving aqueous solution (liquid)
The composition mg/ml
Sodium chloride (isotonic agent) 8
EDTA2Na (chelating agen) 1
Boric acid (buffer agent) 5
Borax (buffer agent) 1
Purified Water (solvent) is an amount of
Above-mentioned the 1st preparation (powder) and the 2nd preparation (tablet) are packaged in the polyethylene packaging body of aluminum thin film, make a liquid type combination preparation.In addition, will dissolve with aqueous solution (liquid) and be loaded in the PE bottle.
Embodiment 4
Disinfective action with regard to the preparation of embodiment 1～3 and comparative example 1 record is estimated.Be modulated into bacterium several 10 toward 10 milliliters of each dissolvings with aqueous solution with record
6The 1st preparation and the 2nd preparation that add embodiment 1～3 and comparative example 1 in the solution of cfu/ milliliter respectively simultaneously after each the 2nd preparation dissolving finishes, are collected this liquid respectively and are placed Petri dish for 1 milliliter, detect viable count.The result is as shown in table 1.
Table 1
Disinfective action experiment (cfu/ml)
As seen from Table 1, the preparation of embodiment 1～3 has tangible disinfective action.In addition, because the 2nd preparation does not have delayed release coating, disinfectant is neutralized immediately, thereby can not get disinfective action fully in comparative example 1.
| The inoculation bacterium | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 |
| S.aureus | 0 | 0 | 0 | 10 6 |
| P.aeruginosa | 0 | 0 | 0 | 10 6 |
| E.coli | 0 | 0 | 0 | 10 6 |
| S.marcescens | 0 | 0 | 0 | 10 6 |
| C.albicans | 0 | 0 | 0 | 10 6 |
| A.niger | 0 | 0 | 0 | 10 6 |
Embodiment 5
Estimate the clean result of the preparation of embodiment 1～3 record.The HEMA eyeglass is placed 0.1% lysozyme soln, heated 30 minutes down, make the lysozyme of adhesion heat degeneration on the eyeglass at 80 ℃.This eyeglass is cleaned with normal saline, obtained artificial contamination's eyeglass.In unfixing each vial of directly packing into of this artificial contamination's eyeglass, each the dissolving aqueous solution that adds record among 8 milliliters of embodiment 1～3, in vial, add the 1st preparation and the 2nd preparation again, take out eyeglass after 4 hours, measuring stain adheres to front and back and handles the light transmittance of back eyeglass at the 500nm place, be calculated as follows the clearance rate of lysozyme, determine clean result.
Lysozyme clearance rate (%)=(T2-T1)/(T0-T1) * 100
T0: the eyeglass light transmittance before stain adheres to
T1: the eyeglass light transmittance after stain adheres to
T2: the eyeglass light transmittance result after the processing is as shown in table 2.
Table 2
Clean result (stain clearance rate, %)
As seen from Table 2, the preparation of embodiment 1～3 has good clean result.In addition, because of the proteolytic enzyme inactivation, almost there is not clean result in the comparative example 1.
| The experiment sequence number | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 |
| 1 | 78.2 | 88.6 | 90.1 | 10.5 |
| 2 | 85.5 | 82.8 | 89.9 | 5.2 |
| 3 | 88.2 | 91.5 | 85.0 | 8.8 |
| Meansigma methods | 84.0 | 87.5 | 88.3 | 8.2 |
Embodiment 6
Use the rabbit eyes to estimate the safety of preparation.6 pieces of HEMA eyeglasses are fixed in each vial, add the dissolving aqueous solution of 8 milliliters of embodiment 1 record respectively, follow similarly add the 1st preparation and the 2nd preparation in each vial after, leave standstill, in same solution, carry out disinfection, neutralize, wash.After 4 hours, take out each eyeglass, with above-mentioned dissolving with solution washing after, be worn on the eyes of rabbit, wore 8 hours in first day.Used each eyeglass that takes out from the rabbit eyes to carry out repeatedly and above-mentioned same operation after reaching in second day, implemented altogether 5 days, observe the rabbit eyes every day, checks having or not of eye disorder.Criterion (J.H.Draize according to Draize, Association of Food and Drug Officials of the UnitedStates, Topeka, Kansas, the 46th page, nineteen fifty-nine) and wear every day finishes time, and afterwards the having or not of fluorescent staining of conjunctiva judged eye disorder.
The Draize score result of the safety experiment of use rabbit eyes is as shown in table 3.
Table 3
| The eyes sequence number | 1 | 2 | 3 | 4 | 5 | 6 |
| Wear the date | 12345 | 12345 | 12345 | 12345 | 12345 | 12345 |
| The muddy part area of position corneal opacity degree | 00000 00000 | 00000 00000 | 00000 00000 | 00000 00000 | 00000 00000 | 00000 00000 |
| Iris | 00000 | 00000 | 00000 | 00000 | 00000 | 00000 |
| The rubescent edema secretions of conjunctiva | 10111 00000 10000 | 11100 00000 10000 | 11111 00000 10000 | 11111 00000 11001 | 10110 00000 00000 | 10011 00000 10000 |
| Add up to scoring | 40222 | 42200 | 42222 | 44224 | 20220 | 40022 |
| Corneal dyeing | All experimental eyes all are not colored | |||||
The obstacle of cornea is not seen in the contact lens of handling with the preparation of embodiment 1 the record slight rubescent and secretion that only sporadically appears during wearing in addition from the fluorescent staining of cornea.
The preparation of embodiment 2 and embodiment 3 records is not equally seen obstacle yet.
Evaluation criterion according to the Draize method is as shown in table 4.
Table 4
| The position | The degree of reaction | Scoring |
| Cornea | (A) Hun Zhuo degree is transparent, haze-free being dispersed in property and diffusivity muddiness, clear can discern easily translucent of iris, iris has not clear milkiness, can not differentiate the texture of iris, the size of pupil is difficult to recognize nebulousurine, iris is invisible | 0 1 2 3 4 |
| (B) area 0～1/4 1/4～1/2 1/2～3/4 3/4～4/4 of corneal opacity part | 1 2 3 4 | |
| Iris | (A) normally exceed normal folding, hyperemia, swelling, circumcorneal injection (have wherein any or all or its combination), have certain light reflex (slow remove reaction positive) not have light reflex, hemorrhage, significant disorganization (any or all) | 0 1 2 |
| Conjunctiva | (A) the normal significantly congestion of blood vessel dispersivity peony of the rubescent blood vessel of conjunctiva palpebrae and bulbar conjunctiva, each blood vessel is difficult to discern dispersivity beef sample redness | 0 1 2 3 |
| (B) edema of conjunctiva does not have swelling that obviously swelling of some swelling (comprising instant embrane) is arranged, the a little swelling of turning up of eyelid, eyelid is closed half swelling, and eyelid is closed over half | 0 1 2 3 4 | |
| (C) not secretion of secretions, (except the visible lema in place, intact animal's nasal side canthus) has a little secretion secretions to make eyelid and its contiguous hair moistening secretions make eyelid and the hair moistening of considerable part on every side | 0 1 2 3 |
Scoring is determined in symptom and observation according to ocular tissue, and according to the safety that adds up to scoring evaluation preparation.The calculating formula that adds up to scoring:
Add up to scoring=[cornea: A * B * 5+ iris: A * 5+ conjunctiva: (A+B+C) * 2]
Estimate:
0～5 minute: non-stimulated thing
5～15 minutes: slight stimulus object
15～30 minutes: stimulus object
30～60 minutes: the moderate stimulus object
60～80 minutes: moderate～height stimulus object
80～110 minutes: the height stimulus object
According to the present invention, to contain the preparation of iodine series bactericidal agent and proteolytic enzyme and contain the nertralizer of delayed release Cotton seeds and the preparation of surfactant drops in the vial that soft contact lens and aqueous solution are housed simultaneously, really after implementing sterilization at short notice to the antibacterial that adheres on the eyeglass, neutral finishing can be confirmed by naked eyes, be neutralized agent and become colourless because the iodine on aqueous solution and the eyeglass is painted, the protein on the eyeglass and the washing of lipid stains also can be carried out automatically, so can be easy, efficiently and safely carry out disinfection, a series of eyeglass maintenances such as neutralization and washing.
Claims (6)
1. liquid type combination preparation that is used for contact lens disinfection, neutralization and washing, it is characterized in that, contain the 1st preparation of iodine series bactericidal agent and proteolytic enzyme and the 2nd preparation that (B) contains Reducing agent and foaming agent and have a delayed release coating combines by (A), wherein have at least one to contain nonionic surfactant in the 1st preparation and the 2nd preparation.
2. according to a liquid type combination preparation of claim 1 record, wherein the iodine series bactericidal agent of the 1st preparation is povidone-iodine or polyvinyl alcohol iodine.
3. according to a liquid type combination preparation of claim 1 record, wherein the Reducing agent of the 2nd preparation is selected from sodium sulfite, sodium sulfite, sodium thiosulfate, ascorbic acid and sodium ascorbate.
4. according to a liquid type combination preparation of claim 1 record, wherein the delayed release coating of the 2nd preparation can make 1～10 minute hangover of foaming agent at least after the dissolving of the 2nd preparation input is with aqueous solution.
5. according to a liquid type combination preparation of claim 1 record, wherein the 1st preparation is powder or granular dosage form, and the 2nd preparation is tablet or capsule.
6. the method for a contact lens disinfection, neutralization and washing, it is characterized in that, the 1st preparation and the 2nd preparation are dropped into dissolving with in the aqueous solution time simultaneously, at first be dissolved into the yellow contact lens that pollutes of keeping to the aqueous solution of brown at the 1st preparation, carry out the washing and the sterilization of eyeglass, then the Reducing agent of the 2nd preparation and foaming agent begin dissolving in fact, carry out the neutralization of iodine series bactericidal agent thus, aqueous solution become roughly colourless after, from this aqueous solution, take out contact lens.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB971964157A CN1141979C (en) | 1997-04-03 | 1997-04-03 | One-pack preparation for disinfection, neutralization and cleaning of contact lenses and method of disinfection, neutralization and cleaning |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB971964157A CN1141979C (en) | 1997-04-03 | 1997-04-03 | One-pack preparation for disinfection, neutralization and cleaning of contact lenses and method of disinfection, neutralization and cleaning |
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| CN1225021A CN1225021A (en) | 1999-08-04 |
| CN1141979C true CN1141979C (en) | 2004-03-17 |
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| CN114891576A (en) * | 2022-05-31 | 2022-08-12 | 陕西尼得克医疗科技股份有限公司 | Corneal contact lens care solution, preparation method and application thereof |
| CN115595214A (en) * | 2022-10-10 | 2023-01-13 | 陕西尼得克医疗科技股份有限公司（Cn） | Corneal contact lens nursing composition, preparation method and application thereof |
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1997
- 1997-04-03 CN CNB971964157A patent/CN1141979C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN1225021A (en) | 1999-08-04 |
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