CA1244741A - Soft contact lens ambient temperature disinfectant and rinsing solution and method - Google Patents
Soft contact lens ambient temperature disinfectant and rinsing solution and methodInfo
- Publication number
- CA1244741A CA1244741A CA000488615A CA488615A CA1244741A CA 1244741 A CA1244741 A CA 1244741A CA 000488615 A CA000488615 A CA 000488615A CA 488615 A CA488615 A CA 488615A CA 1244741 A CA1244741 A CA 1244741A
- Authority
- CA
- Canada
- Prior art keywords
- composition
- lens
- weight
- present
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Abstract
SOFT CONTACT LENS AMBIENT TEMPERATURE
DISINFECTANT AND RINSING SOLUTION AND METHOD
ABSTRACT
Aqueous compositions for the ambient temperature or cold disinfection of soft contact lenses during non-wearing periods is provided. The composition includes water and a disinfectant composition comprising an effective amount of trimethoprim for killing bacteria, usually between about 0.05% and 4.0% by weight of the total aqueous composi-tion and an effective amount of benzyl alcohol as agent to and adjuvant bactericide, usually between about 0.50% and 5.0% by weight of the total composition and optionally a salt of EDTA. A method is provided for treating the lenses to kill bacteria associated with the lenses.
DISINFECTANT AND RINSING SOLUTION AND METHOD
ABSTRACT
Aqueous compositions for the ambient temperature or cold disinfection of soft contact lenses during non-wearing periods is provided. The composition includes water and a disinfectant composition comprising an effective amount of trimethoprim for killing bacteria, usually between about 0.05% and 4.0% by weight of the total aqueous composi-tion and an effective amount of benzyl alcohol as agent to and adjuvant bactericide, usually between about 0.50% and 5.0% by weight of the total composition and optionally a salt of EDTA. A method is provided for treating the lenses to kill bacteria associated with the lenses.
Description
~z4~7~1 BACKGROUND OF THE INVENTION
Just as there are marked differences in the struc-ture and composition of hard and soft contact lenses, there are also marked differances in the maintenance and care or treatment of the various types of hard, semi-hard and soft lenses. While patient care and treatment of hard contact and uncomplicated or conventional contact lenses is rela-tively simple and uncomplicated, the proper care and treat-ment of the newer soft and hydrophilic lenses has proved to be more complex and time consuming.
The primary differen~e between the conventional hard contact lens and the more complex soft lenses is the marked increase in the polar or water attracting centers of the hydrophilic gel material. It is this property of the hydrophilic gel lens that gives the soft lens its own unique physical properties and clinical behavior. This polar or water attracting center of the gel material is represented in the hydroxyethyl methacrylate bond as a hydroxyl group (-OH) which attracts and holds large amounts of water. It is this high water content held in the expanded matrix of the hydrophilic gel lens which leads to the special diffi-culties in and disinfecting or asepticising the soft hydro-philic lens. The hydrophilic nature of soft contact lenses makes the lenses vulnerable to bacterial contamination.
~Yhile studies have demonstrated that bacteria cannot pene-trate the actual intramolecular pores of the hydrophilic lens, except in defective lenses, the bacteria have an affinity for the protein and tear deposits on the surfaces of the lens matrix. In particular, the tears and fluids absorbed in the soft lenses serve as excellent bacterial culture media. If defects or nicks occur in the lens either during manufacture or subse~uent patient wear, bacteria may find a haven to ~row and be sheltered from superficial lens cleaning and disinfection.
12~474~
Potentially harmful fungi also provide a possible danger to the soft contact lens. Fungi, like bacteria, can thrive in tear secretions or deposits and penetrate the lens material directly if enzymatic degradation of the lens material has taken place.
Other problems can accrue from incorrect and careless handling of the soft lenses by the patient himself.
Many potential contaminants and lens deposits can be trans-ferred from unwashed fingers to the surface of t~e soft lens. These include oily deposits from the skin, sweat, skin lotions and creams, mascara, detergents, lipstick and even nicotine. Controlled studies have demonstrated that bacterial contaminants occur in 43% of the makeup used by women, and fungal contaminants in 12%. Attempts to effect sterilization of the lenses by boiling, for example, can be cumbersome in addition to causing permanent damage to the lenses if done improperly. If the patient has used impure water for storage and rinsing of the lenses, undesirable deposits such as calcium, iron and insoluble divalent and trivalent metallic salts as well as other chemical deposits can collect on the lens surfaces.
Therefore, a need has arisen for an effective composition to counteract and mitigate the above described effects of improper hygiene and lens handling as well as to provide optimum disinfection and storage of the soft lens between lens wearing periods. In addition, the active ingredients of an effective contact lens solution should preferably: l) disinfect clean soft lenses within a period of four to six hours and produce D values of a 90% kill rate of microorganisms, selected fungal and yeast organisms, and viral agents such as herpes simplex; 2) not be easily inac-tivated by small amounts of proteins, lipids or other tear and extraneous components and deposits; 3) not bind to protein-or other lens surface deposits from the eye; and 4) not react with or absorb to the soft lens material or matrix. For example, several antiseptic agents which meet the above requirement for rapid and effective kill of a broad range of microorganisms have proved to be unsuitable for use in soft lens treatment solutions, in that these agents are incompatible with the soft lens material or bind with protein deposits on the surfaces of the lens matrix.
Other antiseptic agents are unacceptable for use in soft lens solutions since they are concentrated by the lens material, to the extent that they cause discomort and potential damage to the corneal surface of the wearer's eyes. Benzalkonium chloride is one such antiseptic agent which meets the requirements for the effective and rapid killing of microorganisms but is unacceptable because it binds with many types of soft lens material and also binds with protein deposits on the lens surface.
One type of cold disinfecting solution for soft contact lenses uses chlorohexidine. However, chlorohexidine is absorbed by the soft contact lens material and gradually eluded into the eye often causing excessive burning, irrita-tion and red eye, in addition to discoloring soft lenses,which can prevent the patient from wearing the lenses.
Therefore, a need has arisen for a highly effec-tive cold storage and disinfecting solution and method for the overnight or interim disinfection and storage of soft, silicone and silicone co polymer contact lenses which meet the aforesaid requirements.
` ~4~7~3L
SUMMARY OF THE INVENTION
In accordance with the present invention, an aqueous storage and disinfecting solution containing trimethoprim and benzyl alcohol for the ambient temperature or cold storage and disinfection of soft, silicone and silicone co-polymer contact lenses is provided. More particularly, the invention provides an effective ambient temperature storage and disinfecting solution for the disinfection and storage of hydrophilic gel lenses, (HEMA) silicone and silicone co-polymer contact lenses, and gelfle~
material soft lenses including, for example, the following plastic gel materials: Hydroxyethyl methacrylate (HEMA) or its analogues, ethlene glycol dimethacrylate (EGMA) or its analogues, silicone and silicone co-polymer contact lenses.
In accordance with the present invention, a method for treating a contact lens is provided to kill bacteria that may be associated with the lens which method comprises contacting the lens with an aqueous composition c~ntaining trimethoprim and benzyl alcohol present together in an effective concentration for killing bacteria. The method is especially suitable for treating soft, silicone and silicone co-polymer contact lenses. No heat disinfecting is required and therefore, problems associated with elevated ~emperature treatment are eliminated.
The aqueous composition in accordance with the invention contains trimethoprim and benzyl alcohol present together in an effective amount of concentration for killing bacteria. Generally, an effective concentration o trime-thoprim is from about 0.01% and 4.0% by weight of the total composition. Generally, an effective amount of benzyl alcohol whic~ acts as an adjuvant bactericide is from about 0.10% to about 5.0% by weight of the total composition. The combination of trimethoprim and benzyl alcohol provides an ambient temperature disinfecting solution that is effective -" ~LZ44~41 in killing microorganisms, fungal organisms and viral agents such as herpes simplex. Generally, benzyl alcohol is present in an amount of from about 0.10% and about 5.0% by weight of the total composition. In addition, another important function of benzyl alcohol is to facilitate the dissolution of trimethoprim in the aqueous composition, thereby making it more feasible to utilize trimethoprim.
A salt of ethylenediaminetetraacetic acid may be included as a buffering agent and to provide increased bactericidal properties. Other buffering agents may also be present as hereinafter described.
The remainder of the composition may comprise solely water or may include various alkaline metal and alkaline earth metal water soluble salts to provide an aqueous composition salt content equivalent to about 0.8%
to about 1.8% sodium chloride by weight of the total aqueous composition. A humectant such as propylene glycol may be optionally included in the composition.
~ ~47~L
DETAILED DESCRIPTION OF THE INVENTION
The aqueous ambient temperature disinfecting compositions for soft, silicone and silicone co~polymer contact lenses of the present invention contain trimethoprim and benzyl alcohol. The compositions in accordance with the invention act as a disinfectant for contact lenses without the necessity for heat disinfecting. The compositions are particularly useful for disinfecting soft, silicone and silicone co-polymer contact lenses, and can also be used with hard lenses. As used herein, the term "disinfectant"
means a substance that destroys or kills bacteria, fungi, yeasts or viruses.
Trimethoprim and benzyl alcohol are present to-gether in the composition in a concentration sufficient to provide a disinfectant solution for soft contact lenses.
Generally, an amount of trimethoprim of from about 0.01% to about 4.0% by weight of the total composition and an amount of benzyl alcohol of from about 0.10% to about 5.0% by weight of the total composition are sufficient concentra-tions to provide a disinfectant solution for soft contactlenses. Trimethoprim is also known as 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)-pyrimidine and as Syraprim. See, for example, The Merck Index, tenth edition, page 1387. Prefer-ably, trimethoprim is present in an amount of about 0.1~5%
by weight of the total composition and benzyl alcohol is present in an amount of about 2.0% by weight of the total composition.
In order to further enhance the disinfectant properties of the composition in accordance with the present invention, ethylenediaminetetmaacetic acid (EDTA) or a water soluble salt of ethylenediaminetetraacetic acid that has disinfectant properties is preferably present in an effective amount for enhancing the D value kill factor relating to bacteria, fungus, yeast and/or viral organisms. A preferred ` ~4~7~
salt of EDTA is the disodium salt (disodium edetate). Other salts of EDTA which may be utilized include, for example, mono-, di-, tri- and tetra-alkali metal salts. Generally, an effective amount of EDTA or salt thereof is from about 0.025% to about 0.5% by weight of the total composition.
Preferably, disodium edetate is present in an amount of about 0.25% by weight of the total composition.
The compositions of the present invention prefer-ably include at least one essentially neutral water-soluble compatible salt to provide tonicity equivalent to between about 0.8% and 1.8% sodium chloride by weight of the total aqueous composition. Thus, the preferred compositions according to the invention provide a tonicity which is about the same as or slightly higher than the tonicity of normal human tear fluid. While hypertonic solutions can be desir-able since the solution will have a greater osmotic pressure than that of the tear fluid of the contact lens wearer, any soluble salts or mixtures of salts, compatible with ocular tissue, can be used to provide the desired tonicity. Pre-ferably, sodium chloride, potassium chloride or mixturesthereof, are used to provide the desired tonicity. It is undPrstood, however, that one or more essentially neutral, water-soluble alkali or alkaline earth metal salts can be substituted in whole or in part or the sodium or potassium chloride in the solutions of the invention, when tonicity adjustment is desired. Preferably, sodium chloride and potassium chloride are utilized in weight ratio of from about 2:1 to about 7:3, respectively.
Preferably, a buffer or buffers are present in the composition. Suitable buffers are known in the art and include, for example, buffers such as sodium bicarbonate.
The preferred combination of buffers is sodium bicarbonate, sodium phosphate (tribasic), sodium bisulfit~ and sodium biphosphate, present in amounts to provide and maintain the desired pH.
47~
Propylene gl~col may optionally be included in the compositions, generally in an amount of from about 0.2% to about 2.5% by weight of the total aqueous composition and preferably in an amount of about 1.0% by weight of the total aqueous composition. The propylene glycol acts as a humectant, preservative and fungal growth inhibitor.
The balance of the composition is purified water U . S . P .
In accordance with one embodiment of the present invention, a treatment method is provided for killing bac-teria associated with contact lenses. A contact lens is treated by storing the lens in an aqueous solution contain-ing trimethoprim and benzyl alcohol present together in an effective concentration for killing bacteria. Any of the solutions in accordance with the invention can be used. The lens is brought into contact with an aqueous composition in accordance with the invention for a period of time sufficient for the composition to kill at least a portion of the bacteria associated with the contact lens. For example, the lens is introduced into a container having a solution in accordance with the invention generally after proper cleaning procedures are followed in an amount sufficient to completely immerse the lens. The container is then closed and the contact lens is allowed to remain in the solution for a time sufficient to disinfect the contact lens. No external source of heat is applied and thus, the lens is stored at ambient temperature.
Generally, storing the lens in a solution in accordance with the invention for about six hours will provide sufficient disinfection of the contact lens or bacteria for wearing the lens. Thus, the method is ideal for overnight storage of contact lenses or storage between wearing periods. However, it is anticipated that for some solutions in accordance with the invention, less than six hours of storage will be sufficient.
- In accordance with the method of the invention, 5 heating of the solution or lens is not required. Thus, the ~Z4~7~
solutions and method of the present invention allow the lens to be disinfected at ambient temperature, eliminating possi-bility of deleterious effects that may occur when the lens is heated.
The aqueous composition in accordance with the invention is preferably utilized as part of the total patient regimen for maintaining and treating soft, silicone and silicone co-polymer contact lenses. Thus, an effective cleaning step or steps is an important part of any effective soft or firm lens treatment and maintenanc`e regimen.
Separate cleaning of the lenses insures that the disinfectant properties of the aqueous solution will not be overwhelmed by gross organic or inorganic deposits and pollutants.
An especially preferred rinsing and cold disin-fecting solution is:
Component Amount (yO by weight) Sodium bicarbonate 0.100 Sodium phosphate (tribasic) 0.030 Sodium biphosphate 0.030 20 Sodium chloride 0.790 Potassium chloride 0.368 Disodium EDTA 0.~50 Trimethoprim 0.125 Sodium bisulfite 0.050 25 Component Amount (/ by weight~
Ben~yl alcohol 2.000 Propylene glycol 1.000 Purified water U.S.P. Balance Whereas the present invention has been described with respect to specific embodiments, it will be understood that various changes and modifications will be suggested to one skilled in the art and it is intended that the invention encompass such changes and modifications as fall within the scope of the appended claims.
Just as there are marked differences in the struc-ture and composition of hard and soft contact lenses, there are also marked differances in the maintenance and care or treatment of the various types of hard, semi-hard and soft lenses. While patient care and treatment of hard contact and uncomplicated or conventional contact lenses is rela-tively simple and uncomplicated, the proper care and treat-ment of the newer soft and hydrophilic lenses has proved to be more complex and time consuming.
The primary differen~e between the conventional hard contact lens and the more complex soft lenses is the marked increase in the polar or water attracting centers of the hydrophilic gel material. It is this property of the hydrophilic gel lens that gives the soft lens its own unique physical properties and clinical behavior. This polar or water attracting center of the gel material is represented in the hydroxyethyl methacrylate bond as a hydroxyl group (-OH) which attracts and holds large amounts of water. It is this high water content held in the expanded matrix of the hydrophilic gel lens which leads to the special diffi-culties in and disinfecting or asepticising the soft hydro-philic lens. The hydrophilic nature of soft contact lenses makes the lenses vulnerable to bacterial contamination.
~Yhile studies have demonstrated that bacteria cannot pene-trate the actual intramolecular pores of the hydrophilic lens, except in defective lenses, the bacteria have an affinity for the protein and tear deposits on the surfaces of the lens matrix. In particular, the tears and fluids absorbed in the soft lenses serve as excellent bacterial culture media. If defects or nicks occur in the lens either during manufacture or subse~uent patient wear, bacteria may find a haven to ~row and be sheltered from superficial lens cleaning and disinfection.
12~474~
Potentially harmful fungi also provide a possible danger to the soft contact lens. Fungi, like bacteria, can thrive in tear secretions or deposits and penetrate the lens material directly if enzymatic degradation of the lens material has taken place.
Other problems can accrue from incorrect and careless handling of the soft lenses by the patient himself.
Many potential contaminants and lens deposits can be trans-ferred from unwashed fingers to the surface of t~e soft lens. These include oily deposits from the skin, sweat, skin lotions and creams, mascara, detergents, lipstick and even nicotine. Controlled studies have demonstrated that bacterial contaminants occur in 43% of the makeup used by women, and fungal contaminants in 12%. Attempts to effect sterilization of the lenses by boiling, for example, can be cumbersome in addition to causing permanent damage to the lenses if done improperly. If the patient has used impure water for storage and rinsing of the lenses, undesirable deposits such as calcium, iron and insoluble divalent and trivalent metallic salts as well as other chemical deposits can collect on the lens surfaces.
Therefore, a need has arisen for an effective composition to counteract and mitigate the above described effects of improper hygiene and lens handling as well as to provide optimum disinfection and storage of the soft lens between lens wearing periods. In addition, the active ingredients of an effective contact lens solution should preferably: l) disinfect clean soft lenses within a period of four to six hours and produce D values of a 90% kill rate of microorganisms, selected fungal and yeast organisms, and viral agents such as herpes simplex; 2) not be easily inac-tivated by small amounts of proteins, lipids or other tear and extraneous components and deposits; 3) not bind to protein-or other lens surface deposits from the eye; and 4) not react with or absorb to the soft lens material or matrix. For example, several antiseptic agents which meet the above requirement for rapid and effective kill of a broad range of microorganisms have proved to be unsuitable for use in soft lens treatment solutions, in that these agents are incompatible with the soft lens material or bind with protein deposits on the surfaces of the lens matrix.
Other antiseptic agents are unacceptable for use in soft lens solutions since they are concentrated by the lens material, to the extent that they cause discomort and potential damage to the corneal surface of the wearer's eyes. Benzalkonium chloride is one such antiseptic agent which meets the requirements for the effective and rapid killing of microorganisms but is unacceptable because it binds with many types of soft lens material and also binds with protein deposits on the lens surface.
One type of cold disinfecting solution for soft contact lenses uses chlorohexidine. However, chlorohexidine is absorbed by the soft contact lens material and gradually eluded into the eye often causing excessive burning, irrita-tion and red eye, in addition to discoloring soft lenses,which can prevent the patient from wearing the lenses.
Therefore, a need has arisen for a highly effec-tive cold storage and disinfecting solution and method for the overnight or interim disinfection and storage of soft, silicone and silicone co polymer contact lenses which meet the aforesaid requirements.
` ~4~7~3L
SUMMARY OF THE INVENTION
In accordance with the present invention, an aqueous storage and disinfecting solution containing trimethoprim and benzyl alcohol for the ambient temperature or cold storage and disinfection of soft, silicone and silicone co-polymer contact lenses is provided. More particularly, the invention provides an effective ambient temperature storage and disinfecting solution for the disinfection and storage of hydrophilic gel lenses, (HEMA) silicone and silicone co-polymer contact lenses, and gelfle~
material soft lenses including, for example, the following plastic gel materials: Hydroxyethyl methacrylate (HEMA) or its analogues, ethlene glycol dimethacrylate (EGMA) or its analogues, silicone and silicone co-polymer contact lenses.
In accordance with the present invention, a method for treating a contact lens is provided to kill bacteria that may be associated with the lens which method comprises contacting the lens with an aqueous composition c~ntaining trimethoprim and benzyl alcohol present together in an effective concentration for killing bacteria. The method is especially suitable for treating soft, silicone and silicone co-polymer contact lenses. No heat disinfecting is required and therefore, problems associated with elevated ~emperature treatment are eliminated.
The aqueous composition in accordance with the invention contains trimethoprim and benzyl alcohol present together in an effective amount of concentration for killing bacteria. Generally, an effective concentration o trime-thoprim is from about 0.01% and 4.0% by weight of the total composition. Generally, an effective amount of benzyl alcohol whic~ acts as an adjuvant bactericide is from about 0.10% to about 5.0% by weight of the total composition. The combination of trimethoprim and benzyl alcohol provides an ambient temperature disinfecting solution that is effective -" ~LZ44~41 in killing microorganisms, fungal organisms and viral agents such as herpes simplex. Generally, benzyl alcohol is present in an amount of from about 0.10% and about 5.0% by weight of the total composition. In addition, another important function of benzyl alcohol is to facilitate the dissolution of trimethoprim in the aqueous composition, thereby making it more feasible to utilize trimethoprim.
A salt of ethylenediaminetetraacetic acid may be included as a buffering agent and to provide increased bactericidal properties. Other buffering agents may also be present as hereinafter described.
The remainder of the composition may comprise solely water or may include various alkaline metal and alkaline earth metal water soluble salts to provide an aqueous composition salt content equivalent to about 0.8%
to about 1.8% sodium chloride by weight of the total aqueous composition. A humectant such as propylene glycol may be optionally included in the composition.
~ ~47~L
DETAILED DESCRIPTION OF THE INVENTION
The aqueous ambient temperature disinfecting compositions for soft, silicone and silicone co~polymer contact lenses of the present invention contain trimethoprim and benzyl alcohol. The compositions in accordance with the invention act as a disinfectant for contact lenses without the necessity for heat disinfecting. The compositions are particularly useful for disinfecting soft, silicone and silicone co-polymer contact lenses, and can also be used with hard lenses. As used herein, the term "disinfectant"
means a substance that destroys or kills bacteria, fungi, yeasts or viruses.
Trimethoprim and benzyl alcohol are present to-gether in the composition in a concentration sufficient to provide a disinfectant solution for soft contact lenses.
Generally, an amount of trimethoprim of from about 0.01% to about 4.0% by weight of the total composition and an amount of benzyl alcohol of from about 0.10% to about 5.0% by weight of the total composition are sufficient concentra-tions to provide a disinfectant solution for soft contactlenses. Trimethoprim is also known as 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)-pyrimidine and as Syraprim. See, for example, The Merck Index, tenth edition, page 1387. Prefer-ably, trimethoprim is present in an amount of about 0.1~5%
by weight of the total composition and benzyl alcohol is present in an amount of about 2.0% by weight of the total composition.
In order to further enhance the disinfectant properties of the composition in accordance with the present invention, ethylenediaminetetmaacetic acid (EDTA) or a water soluble salt of ethylenediaminetetraacetic acid that has disinfectant properties is preferably present in an effective amount for enhancing the D value kill factor relating to bacteria, fungus, yeast and/or viral organisms. A preferred ` ~4~7~
salt of EDTA is the disodium salt (disodium edetate). Other salts of EDTA which may be utilized include, for example, mono-, di-, tri- and tetra-alkali metal salts. Generally, an effective amount of EDTA or salt thereof is from about 0.025% to about 0.5% by weight of the total composition.
Preferably, disodium edetate is present in an amount of about 0.25% by weight of the total composition.
The compositions of the present invention prefer-ably include at least one essentially neutral water-soluble compatible salt to provide tonicity equivalent to between about 0.8% and 1.8% sodium chloride by weight of the total aqueous composition. Thus, the preferred compositions according to the invention provide a tonicity which is about the same as or slightly higher than the tonicity of normal human tear fluid. While hypertonic solutions can be desir-able since the solution will have a greater osmotic pressure than that of the tear fluid of the contact lens wearer, any soluble salts or mixtures of salts, compatible with ocular tissue, can be used to provide the desired tonicity. Pre-ferably, sodium chloride, potassium chloride or mixturesthereof, are used to provide the desired tonicity. It is undPrstood, however, that one or more essentially neutral, water-soluble alkali or alkaline earth metal salts can be substituted in whole or in part or the sodium or potassium chloride in the solutions of the invention, when tonicity adjustment is desired. Preferably, sodium chloride and potassium chloride are utilized in weight ratio of from about 2:1 to about 7:3, respectively.
Preferably, a buffer or buffers are present in the composition. Suitable buffers are known in the art and include, for example, buffers such as sodium bicarbonate.
The preferred combination of buffers is sodium bicarbonate, sodium phosphate (tribasic), sodium bisulfit~ and sodium biphosphate, present in amounts to provide and maintain the desired pH.
47~
Propylene gl~col may optionally be included in the compositions, generally in an amount of from about 0.2% to about 2.5% by weight of the total aqueous composition and preferably in an amount of about 1.0% by weight of the total aqueous composition. The propylene glycol acts as a humectant, preservative and fungal growth inhibitor.
The balance of the composition is purified water U . S . P .
In accordance with one embodiment of the present invention, a treatment method is provided for killing bac-teria associated with contact lenses. A contact lens is treated by storing the lens in an aqueous solution contain-ing trimethoprim and benzyl alcohol present together in an effective concentration for killing bacteria. Any of the solutions in accordance with the invention can be used. The lens is brought into contact with an aqueous composition in accordance with the invention for a period of time sufficient for the composition to kill at least a portion of the bacteria associated with the contact lens. For example, the lens is introduced into a container having a solution in accordance with the invention generally after proper cleaning procedures are followed in an amount sufficient to completely immerse the lens. The container is then closed and the contact lens is allowed to remain in the solution for a time sufficient to disinfect the contact lens. No external source of heat is applied and thus, the lens is stored at ambient temperature.
Generally, storing the lens in a solution in accordance with the invention for about six hours will provide sufficient disinfection of the contact lens or bacteria for wearing the lens. Thus, the method is ideal for overnight storage of contact lenses or storage between wearing periods. However, it is anticipated that for some solutions in accordance with the invention, less than six hours of storage will be sufficient.
- In accordance with the method of the invention, 5 heating of the solution or lens is not required. Thus, the ~Z4~7~
solutions and method of the present invention allow the lens to be disinfected at ambient temperature, eliminating possi-bility of deleterious effects that may occur when the lens is heated.
The aqueous composition in accordance with the invention is preferably utilized as part of the total patient regimen for maintaining and treating soft, silicone and silicone co-polymer contact lenses. Thus, an effective cleaning step or steps is an important part of any effective soft or firm lens treatment and maintenanc`e regimen.
Separate cleaning of the lenses insures that the disinfectant properties of the aqueous solution will not be overwhelmed by gross organic or inorganic deposits and pollutants.
An especially preferred rinsing and cold disin-fecting solution is:
Component Amount (yO by weight) Sodium bicarbonate 0.100 Sodium phosphate (tribasic) 0.030 Sodium biphosphate 0.030 20 Sodium chloride 0.790 Potassium chloride 0.368 Disodium EDTA 0.~50 Trimethoprim 0.125 Sodium bisulfite 0.050 25 Component Amount (/ by weight~
Ben~yl alcohol 2.000 Propylene glycol 1.000 Purified water U.S.P. Balance Whereas the present invention has been described with respect to specific embodiments, it will be understood that various changes and modifications will be suggested to one skilled in the art and it is intended that the invention encompass such changes and modifications as fall within the scope of the appended claims.
Claims (16)
1. A method of treating a contact lens to kill bacteria associated therewith comprising:
(a) placing the lens in contact with an aqueous composition, said composition comprising water, trimethoprim and benzyl alcohol present together in an effective amount to kill bacteria; and (b) maintaining the lens in contact with said aqueous composition for a time sufficient to kill bacteria.
(a) placing the lens in contact with an aqueous composition, said composition comprising water, trimethoprim and benzyl alcohol present together in an effective amount to kill bacteria; and (b) maintaining the lens in contact with said aqueous composition for a time sufficient to kill bacteria.
2. The method as recited in claim 1 wherein the lens is completely immersed in said composition for a period of about six hours.
3. The method as recited in claim 1 wherein the lens is completely immersed in said composition over-night or between wearing periods.
4. The method as recited in claim 1 wherein trimethoprim is present in an amount of from about 0.01%
to about 4.0% and benzyl alcohol is present in an amount of from about 0.10% to about 5.0%, by weight of the total aqueous composition.
to about 4.0% and benzyl alcohol is present in an amount of from about 0.10% to about 5.0%, by weight of the total aqueous composition.
5. The method as recited in claim 4 wherein the concentration of trimethoprim compound is about 0.125%
and the concentration of benzyl alcohol is about 2.0%, by weight of the total aqueous composition.
and the concentration of benzyl alcohol is about 2.0%, by weight of the total aqueous composition.
6. The method as recited in claim 1 wherein said aqueous composition further comprises ethylenediaminetetra-acetic acid or a water soluble salt thereof.
7. The method as recited in claim 6 wherein ethylenediaminetetraacetic acid or a water soluble salt thereof is present in an amount of from about 0.025% and 0.5% by weight of the total aqueous composition.
8. An aqueous composition for ambient tempera-ture disinfection of soft contact lenses comprising trimethoprim and benzyl alcohol present together in an effective amount to kill bacteria, said composition being compatible with soft contact lenses.
9. The composition of claim 8 wherein trimethoprim is present in an amount of from about 0.01% to about 4.0%
and benzyl alcohol is present in an amount of from about 0.1% to about 5.0%, by weight of the total composition.
and benzyl alcohol is present in an amount of from about 0.1% to about 5.0%, by weight of the total composition.
10. The composition of claim 8 further comprising ethylenediaminetetraacetic acid or a water soluble salt thereof.
11. The composition of claim 10 wherein disodium edetate is present in an amount of from about 0.025% to about 0.5% by weight of the total composition.
12. The composition of claim 10 wherein disodium edetate is present in an amount of about 0.25% by weight of the total composition.
13. The composition of claim 8 wherein the composition has a tonicity of from about 0.8 to about 1.8.
14. The composition of claim 8 further comprising at least one buffering compound.
15. The composition of claim 12 wherein said at least one buffering compound is selected from the group consisting of sodium bicarbonate, sodium phosphate, sodium bisulfite and sodium biphosphate.
16. The composition of claim 14 wherein the composition contains, by weight of the total composition, about 0.125% trimethoprim, about 2.0% benzyl alcohol, about 0.25% of the disodium salt of ethylenediaminetetraacetic acid, about 0.10% sodium bicarbonate, about 0.03% sodium phosphate, about 0.03% sodium bisphosphate, about 0.79%
sodium chloride, about 0.368% potassium chloride, about 0.05% sodium bisulfite and about 1.0% propylene glycol.
sodium chloride, about 0.368% potassium chloride, about 0.05% sodium bisulfite and about 1.0% propylene glycol.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US642,088 | 1984-08-20 | ||
| US06/642,088 US4551461A (en) | 1982-06-01 | 1984-08-20 | Soft contact lens ambient temperature disinfectant and rinsing solution and method |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA1244741A true CA1244741A (en) | 1988-11-15 |
Family
ID=24575146
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA000488615A Expired CA1244741A (en) | 1984-08-20 | 1985-08-13 | Soft contact lens ambient temperature disinfectant and rinsing solution and method |
Country Status (2)
| Country | Link |
|---|---|
| JP (1) | JPS6159420A (en) |
| CA (1) | CA1244741A (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4763909B2 (en) * | 2001-03-30 | 2011-08-31 | 小林製薬株式会社 | Contact lens cleaner |
| JP4728796B2 (en) * | 2005-12-16 | 2011-07-20 | アイシン精機株式会社 | Clip mounting structure for vehicle molding |
-
1985
- 1985-08-13 CA CA000488615A patent/CA1244741A/en not_active Expired
- 1985-08-20 JP JP18288685A patent/JPS6159420A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| JPS6159420A (en) | 1986-03-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US4551461A (en) | Soft contact lens ambient temperature disinfectant and rinsing solution and method | |
| US4367157A (en) | Soft contact lens ambient temperature disinfectant solution containing ascorbic acid or salt thereof | |
| EP0076136B1 (en) | Ophthalmic solutions | |
| US6162393A (en) | Contact lens and ophthalmic solutions | |
| KR0160443B1 (en) | Aqueous ophthalmic solutions and method for preserving the same | |
| US4529535A (en) | Soft contact lens wetting solution containing preservative system and method | |
| EP2155271B1 (en) | Phospholipid compositions for contact lens care and preservation of pharmaceutical compositions | |
| JPH05502874A (en) | Non-oxidative ophthalmic composition and its storage and use method | |
| JPH05503513A (en) | Ophthalmic compositions and their storage and use methods | |
| US4626292A (en) | Soft contact lens wetting and preservation method | |
| US4356100A (en) | Soft contact lens cold disinfectant solution | |
| US4510065A (en) | Soft contact lens preservative system, prophylactic cleaner and method | |
| CA2152077A1 (en) | Contact lens disinfecting solution containing sodium chlorite and polyvinyl pyrrolidone | |
| EP0884058B1 (en) | Solution for preserving and sterilizing contact lenses | |
| US4401582A (en) | Soft contact lens ambient temperature disinfectant solution and method | |
| CA1244741A (en) | Soft contact lens ambient temperature disinfectant and rinsing solution and method | |
| ES2342671T3 (en) | ANTIMICROBIAL COMPOSITIONS AND USES OF THE SAME. | |
| US4444785A (en) | Contact lens disinfecting and preserving solution | |
| EP0175490A2 (en) | Contact lens treatment compositions and their uses | |
| JPH08500382A (en) | Preservative system for ophthalmic solutions and contact lens solutions and method for cleaning, disinfecting and preserving contact lenses | |
| RU2262342C1 (en) | Composition for treatment and storage of soft contact lens | |
| US4381314A (en) | Contact lens disinfecting and preserving solution | |
| JPS6169023A (en) | Solution containing antiseptic for wetting soft contact lensand sedation inside eye and method therefor | |
| KR940006102B1 (en) | Preserving solution of contact lenses | |
| JP2000347141A (en) | Treating liquid for hydrous contact lens |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MKEX | Expiry |