CN114191602A - 一种藻酸盐缓释抗菌敷料及其制备方法 - Google Patents

一种藻酸盐缓释抗菌敷料及其制备方法 Download PDF

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CN114191602A
CN114191602A CN202010985251.5A CN202010985251A CN114191602A CN 114191602 A CN114191602 A CN 114191602A CN 202010985251 A CN202010985251 A CN 202010985251A CN 114191602 A CN114191602 A CN 114191602A
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alginate
gel matrix
release antibacterial
stirring
cyclodextrin
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任小燕
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Nantong Yule Medical Dressing Co ltd
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Nantong Yule Medical Dressing Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0004—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing inorganic materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0057—Ingredients of undetermined constitution or reaction products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0066—Medicaments; Biocides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/008—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/10—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing inorganic materials
    • A61L2300/102—Metals or metal compounds, e.g. salts such as bicarbonates, carbonates, oxides, zeolites, silicates
    • A61L2300/104—Silver, e.g. silver sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/404—Biocides, antimicrobial agents, antiseptic agents

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Abstract

本发明公开了一种藻酸盐缓释抗菌敷料及其制备方法，一种藻酸盐缓释抗菌敷料，包括凝胶基质、银离子、环糊精、银离子释放剂，所述凝胶基质包括藻酸盐、菊花提取物和决明子粉末，所述凝胶基质内藻酸盐的重量成分比例为30‑60％，此敷料抗菌效果好，使用时间长，制备简单。

Description

一种藻酸盐缓释抗菌敷料及其制备方法
技术领域
本发明属于医用抗菌辅料领域，尤其涉及一种藻酸盐缓释抗菌敷料及其制备方法。
背景技术
海藻酸盐为原料研发的海藻纤维具有无毒性、高吸水成凝胶性、高透氧性、良好的生物相容性、整体易去除性、良好的生物降解吸收性、止血性能、能促进伤口愈合、高离子吸附性等优越特性，已被广泛应用于生物医学的研究。海藻酸作为可吸收止血材料，其对细菌生长有抑制作用。藻酸生物敷料从天然海藻中提取，加工过程中使用的材料没有任何毒性，因而海藻酸纤维生物敷料对人体无毒。
银及其化合物以其优良的抗菌和抑菌性能已经在医学、卫生等领域得到了广泛应用。银离子因其抗菌能力强等优点被选用作抗菌材料已有悠久的历史，银离子被认为具有广谱的抗菌活性，对革兰阴性菌、革兰阳性菌、真菌及部分病毒等均有抗菌作用，甚至对一些耐药菌株都显示出很强的抗菌作用。载银离子敷料因其持续释放出用于抗菌、抑菌的银离子或原子，从而避免伤口感染。
发明内容
本发明所解决的技术问题在于提供一种藻酸盐缓释抗菌敷料及其制备方法。
本发明的的目的可以通过以下技术方案来实现：
一种藻酸盐缓释抗菌敷料，包括凝胶基质、银离子、环糊精、银离子释放剂，所述凝胶基质包括藻酸盐、菊花提取物和决明子粉末，所述凝胶基质内藻酸盐的重量成分比例为30-60％。
优选的，所述环糊精的总重量成分比例不小于90％。
一种藻酸盐缓释抗菌敷料的制备方法，包括
将海藻酸盐和β-环糊精，混合加入去离子水，在高温下，边搅拌边添加，完全添加后搅拌半小时加入菊花提取物和决明子粉末继续搅拌，搅拌完全后，加入银离子和银离子释放剂继续搅拌，逐渐降温至室温得到凝胶基质，凝胶基质上加入环糊精将凝胶基质包裹得到敷料。
本发明的有益效果：
此敷料抗菌效果好，使用时间长，制备简单。
具体实施方式
本发明的技术方案作进一步的描述：
一种藻酸盐缓释抗菌敷料，包括凝胶基质、银离子、环糊精、银离子释放剂，所述凝胶基质包括藻酸盐、菊花提取物和决明子粉末，所述凝胶基质内藻酸盐的重量成分比例为30-60％。
本实施例中，优选的，所述环糊精的总重量成分比例不小于90％。
一种藻酸盐缓释抗菌敷料的制备方法，包括
将海藻酸盐和β-环糊精，混合加入去离子水，在高温下，边搅拌边添加，完全添加后搅拌半小时加入菊花提取物和决明子粉末继续搅拌，搅拌完全后，加入银离子和银离子释放剂继续搅拌，逐渐降温至室温得到凝胶基质，凝胶基质上加入环糊精将凝胶基质包裹得到敷料。
最后应说明的是：
本领域技术人员可以参考本文内容，实施该方法，实现其应用，特别需要指出的是，所有类似的替换和改动对本领域技术人员来说是显而易见的，它们都被视为包括在本发明内。本发明的方法及应用己经通过较佳的实施例进行了描述，相关人员明显能在不脱离本发明内容、精神和范围内对本文制各方法和应用进行改动或适当变更与组合，来实现和应用本发明技术。
以上实施例仅用以说明而非限制本发明的技术方案，尽管参照上述实施例对本发明进行了详细说明，本领域的普通技术人员应当理解：依然可以对本发明进行修改或者等同替换，而不脱离本发明的精神和范围，而所附权利要求意在涵盖落入本发明精神和范围中的这些修改或者等同替换。

Claims (3)

1.一种藻酸盐缓释抗菌敷料，其特征在于：包括凝胶基质、银离子、环糊精、银离子释放剂，所述凝胶基质包括藻酸盐、菊花提取物和决明子粉末，所述凝胶基质内藻酸盐的重量成分比例为30-60％。
2.如权利要求1所述的一种藻酸盐缓释抗菌敷料，其特征在于：所述环糊精的总重量成分比例不小于90％。
3.一种如权利要求1所述的藻酸盐缓释抗菌敷料的制备方法，其特征在于：将海藻酸盐和β-环糊精，混合加入去离子水，在高温下，边搅拌边添加，完全添加后搅拌半小时加入菊花提取物和决明子粉末继续搅拌，搅拌完全后，加入银离子和银离子释放剂继续搅拌，逐渐降温至室温得到凝胶基质，凝胶基质上加入环糊精将凝胶基质包裹得到敷料。
CN202010985251.5A 2020-09-18 2020-09-18 一种藻酸盐缓释抗菌敷料及其制备方法 Withdrawn CN114191602A (zh)

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