CN1141769A - Usage of dihydroxy acetone - Google Patents
Usage of dihydroxy acetone Download PDFInfo
- Publication number
- CN1141769A CN1141769A CN 96102040 CN96102040A CN1141769A CN 1141769 A CN1141769 A CN 1141769A CN 96102040 CN96102040 CN 96102040 CN 96102040 A CN96102040 A CN 96102040A CN 1141769 A CN1141769 A CN 1141769A
- Authority
- CN
- China
- Prior art keywords
- amine
- compositions
- agent
- skin
- lightscreening agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/35—Ketones, e.g. benzophenone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
- Package Specialized In Special Use (AREA)
Abstract
The invention relates to the use of dihydroxyacetone for improving the skin adhesion of amine-contain-ing sunscreen filters, and to a container system for applying a sunscreen composition having improved skin adhesion, which has the following constituents: (a) a chamber containing a fluid or pasty composition comprising dihydroxyacetone (b) a chamber containing a fluid or pasty composition comprising an amine-containing sunscreen filter (c) a device for the simultaneous application of the compositions of the first and the second chambers.
Description
Dihydroxy acetone is used to improve the purposes of the skin adherence that contains the amine lightscreening agent.
Known skin has responsive reaction to solar rays, and it can cause general sunburn or erythema, but also can cause obviously burning more or less.
But solar rays also has other ill effect: form wrinkle thereby they follow the string skin and cause premature aging.Sometimes also can find dermatosis.Under extreme case, skin carcinoma can appear in some people.
In order to prevent the change color of hair, the variation of bleaching or the injury of mechanical factor, the hair that also needs protection avoids the photochemistry injury.
The contained amine lightscreening agent that contains in the known cosmetics, as para-aminobenzoic acid or Phenylbenzimidazolesulfonic acid, its optical filtering is strong but skin adherence is poor.
The strongest part of hazardness is to be formed by the ultraviolet of wavelength less than 400nm in the known solar rays.Also known existence owing to ozone layer in the atmosphere, it has absorbed the part solar radiation, and the ultraviolet lower limit that therefore arrives earth surface is about 280nm.
Therefore, the preparation that has improved skin adherence or cleaning is had stability that needs preparation to be suitable for, but its absorbing wavelength scope is from 280 to 400nm ultraviolet (UV) line, promptly in addition wavelength be the ray UV-B of 280-320nm, its formation to sunburn plays significant feature, and wavelength is the ray UV-A of 320-400nm, it makes skin tanning and can make it aging, help the triggering of erythematous response or strengthen some people's this reaction, perhaps also can trigger phototoxicity or photoallergic reaction.
Lightscreening agent commonly used is divided into UVA and UVB lightscreening agent in the cosmetics at present.In UVB scope (280-320nm) as Eusolex
R6300 or Eusolex
R232 such materials are lightscreening agents preferably, but then there is following point in the material that is used for UVA scope (320-400nm).
Dibenzoyl methane such as Eusolex
9020 or Eusolex
8020 is not very stable under ultraviolet radiation, and its filtration reduces in time on the one hand, then can increase the heliosensitivity of skin on the other hand in some cases.Equally, the benzophenone that is used as the UVA lightscreening agent is dissolved in the used for cosmetic oily thing only limitedly, and its trap is very low.By contrast, only know some water solublity UVA lightscreening agents at present, but their uv absorption is very weak.
US4,434,154 disclose the cosmetic formulations that produces artificial skin darkening simultaneously and contain the UV lightscreening agent.
These prescriptions contain dihydroxy acetone and octyl group N, and N-dimethyl-Para-Aminobenzoic is as reactive compound.But wherein do not indicate by using dihydroxy acetone can increase the skin adherence of UV lightscreening agent.
By comparison, US3 is unequivocally opposed in 177,120 dihydroxy acetone is mixed mutually with the UV lightscreening agent of amino-contained.
Surprisingly, have now found that dihydroxy acetone can anchor at lightscreening agent on the skin, formed a waterproof filter layer and keep a few days.
The available UV lightscreening agent that these have high extinction coefficient is mixed with sunscreen composition, has very strong interception in the said composition and the used concentration of long-effective protection effect is then very low.
In addition, also can be used for scytitis or prophylactic treatment hypersensitive, and be used to prevent the cancer of some type according to preparation of the present invention.
Other advantage of these preparations is nontoxic or irritating property of nothing, and harmless fully to skin.
It is distributed in the common cosmetics carrier equably, particularly in the Lipid carriers, can form the successive film of one deck; They can this kind mode be used for skin and form the effective protecting film of one deck.
The present invention relates to the purposes that dihydroxy acetone is used to improve the skin adherence that contains the amine lightscreening agent, preferably containing the amine lightscreening agent is secondary amine or primary amine, particularly para-aminobenzoic acid or para-aminobenzoic acid ester.
In preferred embodiments, will contain dihydroxy acetone and at least a compositions that contains amine UV lightscreening agent is used for skin and it is worked.
In a further preferred embodiment, use said composition, in the chamber compositions that contains dihydroxy acetone is housed, the compositions that contains the amine lightscreening agent is housed in another chamber in the mode of container with two separation chambers.
The invention further relates to a kind of containment system that is used to improve the barrier compositions of skin adherence, comprising following part: a) liquid state that contains dihydroxy acetone or the chamber of paste composition are housed, b) liquid state or the paste composition that contains the amine lightscreening agent is housed, c) is used for using simultaneously the device of the compositions of first and second Room.
Similarly be used for using simultaneously existing description of containment system of the cosmetic composition that contains dihydroxy acetone and primary amine, for example WO94/04130.
But, wherein never mention the skin adherence that can improve the UV opacifier that contains amine with such system.
The invention further relates to a kind of preparation of cosmetics, said preparation contains the dihydroxy acetone (DHA) and the para-aminobenzoic acid (PA-BA) of effective dose in the cosmetics acceptable carrier.
Cosmetic composition according to the present invention can be used as the protective agent of human epidermal or hair or is used as sunscreen composition.
The invention further relates to a kind of method of protecting skin and natural or sensitization hair to avoid solar radiation, wherein DHA and the PABA with effective dose is used for skin or hair.
" sensitization hair " can be regarded as and be meant through the hair-waving processing, or the hair of hair dyeing or bleaching processing.
If cosmetic composition according to the present invention is to be used to protect human epidermal with anti-ultraviolet, it is a lot of then to be generally used for such form.Specifically, can oily or oil one pure skin lotion, the form of emulsion exists, for example paste or the milk of oil one pure form, an oily water or an oily alcogel or solid bar or be mixed with aerosol.
The adjuvant that wherein can contain cosmetics, these adjuvants are that the type compositions is used always, as adhesion agent, softening agent, wetting agent, surfactant, antiseptic, anti-foam agent, spice, paraffin, lanoline, propellant, can make the dyestuff and/or the pigment of compositions itself or dye, and use other composition always in the cosmetics.
Usually the amount that exists of the UV lightscreening agent of amino-contained is 0.5-10%, and preferred 1-8%, particularly 1-5% are in the gross weight of the cosmetic composition that is used for protecting human epidermis.
Usually, used preparation contains the 0.5-10% that is equivalent to gross weight, the DHA of preferred 1-8%, particularly 1-5%.
Used solubilizing agent can be oil, paraffin or other lipid material, rudimentary unit alcohol or lower polyol or its mixture.Particularly preferred unit alcohol or polyhydric alcohol comprise ethanol, isopropyl alcohol, propylene glycol, glycerol and sorbitol.
The preferred embodiment of the invention is the emulsion that exists with skin care liquid or milk form, wherein also is included in aliphatic alcohol, fatty acid ester, particularly fatty acid triglycercide under the water existence except chemical compound formula I, fatty acid, lanoline, natural or synthetic oils or paraffin, and emulsifying agent.
More preferred case is executed scheme and is based on natural or synthetic oils and paraffin, lanoline, fatty acid ester, the oily skin lotion of fatty acid triglycercide particularly, or based on lower alcohol such as ethanol, or glycol such as propylene glycol, and/or polyhydric alcohol such as glycerol, and the oil one pure skin lotion of oil, paraffin and fatty acid ester such as fatty acid triglycercide.
The form that can also contain alcogel according to cosmetic composition of the present invention exists, and wherein contains one or more lower alcohols or polyhydric alcohol such as ethanol, propylene glycol or glycerol, and adhesion agent, as kieselguhr.Oil one alcogel also contains natural or artificial oil or paraffin in addition.
Contain natural synthetic paraffin and oils in the solid bar, aliphatic alcohol, fatty acid, fatty acid ester, lanoline and other lipid material.
The invention still further relates to the cosmetics barrier agent compositions that can contain DHA and at least a amino-contained UV lightscreening agent, can comprise other UVB and/or UVA lightscreening agent in the said composition.
In this case, the amount of amino-contained UV lightscreening agent is generally 1.0-8.0% weight, is equivalent to the gross weight of sunscreen composition.
As compositions is mixed with aerosol, use common propellant usually, as alkane, fluoric ether and chlorofluoro-alkane.
If chemical compound according to the present invention is to be used to protect the hair of natural or sensitization to avoid the injury of UV line, then the form of the shampoo that can be used to wash, body lotion, gel or Emulsion exists, and particularly is mixed with before and after be used to have one's hair wash front and back, hair dyeing or the rinsing or the preparation before and after the hair-waving; Perhaps compositions exists with the liniment that is used for hair fixing and combing or the form of gel, with the back comb that is used to have one's hair wash logical or fixedly the liniment of hair or the form of gel exist, exist with the form of hair jelly, hair-waving compositions or hair dyeing essence or bleached hair agent.Except chemical compound according to the present invention, said composition can comprise the various adjuvants that are used for the type compositions, as surfactant, adhesion agent, polymer, softening agent, antiseptic, foam stabiliser, electrolyte, organic solvent, silicone derivative, oils, paraffin, degreasing agent make the component of the dyestuff of compositions itself or hair coloring and/or pigment or other hair care commonly used.Said composition contains the UV lightscreening agent of at least a amino-contained of 1.0-5.0% weight usually.
In preferred embodiments, use according to chemical compound of the present invention, the compositions that comprises amino-contained UV lightscreening agent is housed in first chamber in the mode of containment system.Compositions corresponding to first kind of preparation preferably is housed in second chamber, but replaces wherein UV lightscreening agent with DHA.
Usually, the viscosity of the compositions in two chambers is basic identical.
Do not need further explanation, can infer that those skilled in the art can further expand according to above-mentioned description.Therefore, it is descriptive that embodiment preferred only should be interpreted as, rather than has limited open scope of the present invention by any way.
Address following patent on all are disclosed and publication is incorporated herein by reference as prior art here.
Following embodiment is a representative embodiment of the present invention.
Embodiment 1:
Experiment in vitro:
Following material is applied to gelatin foil:
A: the amine in 50% ethanol
B: amine in 50% ethanol and 5%DHA.
With following material as amine: 0.05%Neofuchsin, 3%PABA or 3%Eu-solex232 (can be, Darmstadt buy) from E.Merck.Every kind of solution 0.5ml is applied to gelatin, and under 40 ℃ and 86% humidity placing response 2 days.Mix with the ethanol of 20ml70% then, and stirred 1 hour.In the scope of 200-800nm, measure the delustring of upper solution.So just, how much amine has measured has be not incorporated into gelatin.Delustring is low more, and the amine that is incorporated into gelatin is many more.Draw following result: amine Emax (amine) Emax (Neofuchsin 0.562 0.421Eusolex232 0.487 0.443PABA 0.751 0.334 of amine+DHA)
By using DHA only to have small amount of N eofuchsin and Eusolex232 to be incorporated into gelatin, delustring changes then clearly for PABA.
Embodiment 2:
PABA is applied to whole body and on a side repaste of tester's health DHA, react after 3 hours, use the soap shower.So remove most of bronzing DHA that produces.Sight was bathed after 3 hours, obtained following result:
Only using the side of PABA:
Chest and back are little red, and the arm moderate reddens.
Together using the side of PABA with DHA:
Only arm reddens slightly.
Clearly, although fully flushing still has part PABA to anchor on the skin, thereby the protection health is avoided sun-damaged.
Embodiment 3:
Shading frost (O/W)
Produced a kind of containment system corresponding to WO94/04130 Fig. 3.The mistress comprises following component:
%A PABA (1)3.00
Emulsifying agent E2155 (2) 8.00
Stearic acid (label 671) (1) 2.00
Liquid paraffin (label 7162) (1) 6.00
Jie Kuai paraffin (label 7158) (1) 6.00 not
Hexadecanol (label 989) (1) 2.50
Miglyol812 (3)9.50
Abil?AV200 (2)0.50
Cetyl palmitate (1) 5.50
Vitamin e acetate (label 500952) (1) 0.05B glycerol (label 4093) (1) 3.00
1,2-propylene glycol (label 7478) (1) 2.00
Karion F liquid (label 2993) (1) 5.00
Allantoin (label 1015) (1) 0.25
Antiseptic is an amount of
Deionized water to 100.00
Preparation:
With A heat phase to 75 ℃, B heat phase to 80 ℃.Slowly stir down and pour B into the A phase mutually.Be stirred to cooling.Add spice in 40 ℃ when needing.
Inner room contains and the corresponding component of last component, but replaces lightscreening agent (PA-BA) with DHA, then it is added in the aqueous phase B.
Raw material sources:
(1)E.Merck,Darmstadt
(2)Th.Go1dschmidt,Essen
(3)Hls?Troisdorf?AG,Witten
Claims (6)
1. dihydroxy acetone is used to improve the purposes of the skin adherence that contains the amine lightscreening agent.
2. according to the purposes of claim 1, it is characterized in that containing the amine lightscreening agent is secondary amine or primary amine.
3. according to the purposes of claim 1 or 2, it is characterized in that containing the amine lightscreening agent is para-amino benzoic acid or p-aminobenzoate.
4. according to the purposes of claim 1 to 3, it is characterized in that being applied to skin and making it and work with containing dihydroxy acetone and at least a compositions that contains amine IV lightscreening agent.
5. according to the purposes of claim 1 to 4, it is characterized in that using said composition in the mode of the container that contains two separation chambers, in the chamber compositions that contains dihydroxy acetone is housed, the compositions that contains the amine lightscreening agent is housed in another chamber.
6. be used to improve the container of the sunscreen composition of skin adherence, it comprises following part:
(a) one is equipped with the liquid state that contains dihydroxy acetone or the chamber of paste composition,
(b) one is equipped with the liquid state that contains the amine lightscreening agent or the chamber of paste composition,
(c) device that is used for using simultaneously the compositions of first and second Room.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DEP19505154.8 | 1995-02-16 | ||
DE1995105154 DE19505154A1 (en) | 1995-02-16 | 1995-02-16 | Use of di:hydroxy:acetone |
Publications (1)
Publication Number | Publication Date |
---|---|
CN1141769A true CN1141769A (en) | 1997-02-05 |
Family
ID=7754093
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN 96102040 Pending CN1141769A (en) | 1995-02-16 | 1996-02-15 | Usage of dihydroxy acetone |
Country Status (6)
Country | Link |
---|---|
JP (1) | JPH08245356A (en) |
CN (1) | CN1141769A (en) |
AU (1) | AU4446396A (en) |
CA (1) | CA2169532A1 (en) |
DE (1) | DE19505154A1 (en) |
FR (1) | FR2730927A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106806382A (en) * | 2015-12-01 | 2017-06-09 | 山西亚宝保健品有限公司 | Anti-cancer composition |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7815900B1 (en) * | 2000-07-11 | 2010-10-19 | L'ORéAL S.A. | Use of C3-C5 monosaccharides to protect keratinous fibers |
DE10137260A1 (en) * | 2001-07-31 | 2003-02-13 | Merck Patent Gmbh | Reinforcing the UV-A protective effect of dihydroxyacetone in cosmetic compositions, involves adding di-N-heterocyclic compounds, especially pyrimidine carboxylic acid derivatives |
IT1398503B1 (en) * | 2010-02-24 | 2013-03-01 | Alderan S A S Di Alderano Mannozzi & C Ora Alderan S A S Di D Ottavi Adele & C | USE OF TAMPONANT SUBSTANCES TO MAKE THE CURLY HAIR, SMOOTH OR CORRUGATED. |
KR101965319B1 (en) * | 2015-08-24 | 2019-04-04 | 샨시 야바오 헬스 프로덕츠 컴퍼니 리미티드 | Use of dihydroxyacetone in the manufacture of antitumor drugs |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE588291A (en) * | 1959-03-09 | |||
FR1252400A (en) * | 1960-03-22 | 1961-01-27 | Nestle Lemur Company | Process and products for coloring keratinous substances |
FR1566396A (en) * | 1968-02-22 | 1969-05-09 | ||
US4434154A (en) * | 1981-01-26 | 1984-02-28 | Plough, Inc. | Tanning and ultra-violet screening composition having high stability |
KR930011983A (en) * | 1991-12-16 | 1993-07-20 | 원본미기재 | Self-tanner cosmetic composition |
DE69310375T2 (en) * | 1992-08-24 | 1997-10-23 | Schering Plough Healthcare | DEVICE AND METHOD FOR SELF-BROWNING |
-
1995
- 1995-02-16 DE DE1995105154 patent/DE19505154A1/en not_active Ceased
-
1996
- 1996-02-09 AU AU44463/96A patent/AU4446396A/en not_active Abandoned
- 1996-02-14 CA CA 2169532 patent/CA2169532A1/en not_active Abandoned
- 1996-02-14 FR FR9601801A patent/FR2730927A1/en active Pending
- 1996-02-15 CN CN 96102040 patent/CN1141769A/en active Pending
- 1996-02-16 JP JP8029273A patent/JPH08245356A/en active Pending
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN106806382A (en) * | 2015-12-01 | 2017-06-09 | 山西亚宝保健品有限公司 | Anti-cancer composition |
Also Published As
Publication number | Publication date |
---|---|
DE19505154A1 (en) | 1996-08-22 |
CA2169532A1 (en) | 1996-08-17 |
JPH08245356A (en) | 1996-09-24 |
AU4446396A (en) | 1996-08-22 |
FR2730927A1 (en) | 1996-08-30 |
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C06 | Publication | ||
PB01 | Publication | ||
C01 | Deemed withdrawal of patent application (patent law 1993) | ||
WD01 | Invention patent application deemed withdrawn after publication |